<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG34</accession>
    <name>A0A010YG34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="10">1.3.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.6" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847687.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.205"/>
    <dbReference type="HOGENOM" id="CLU_014629_4_0_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="271"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ACOX" evidence="7">
        <location>
            <begin position="487"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="645" mass="70724" checksum="C6F566CEA03F67DF" modified="2014-06-11" version="1">MSDLADLRRVFDGRWAEVRDEARKALRRPEFGLAGDLGRDAHRQHVWELLQQLATVGHSRLGFPTRYGGLGDTGGSVASFEMLGYGDLSLMVKSGVQWGLFGGAIQALGTERHHERYLPPIMSLELPGCFAMTETGHGSDVQHLRTTATYDPAAGEFVVETPHEAARKDYIGGAARDARLAVVFAQLVTTENHGVHAFLVPIRDQDGNPCPGVRIGDCGGKAGLDGVDNGRLWFDRVRIPRENLLNRYGDVAEDGTYSSPIENAGRRFFTMLGTLVRGRVSVAGGAGSATQTALTIAVRYGEVRRQFDAPGRDREVALLDYLAHQRALLPALAKTYALRFAQENLVRTLHELQPADGLADGAAPDGVAQRQLEARAAGLKAVATWHASATIQACREACGGAGYLTENRLPQLRADTDVFTTFEGDNRVLLQLVAKGLLTGYRDQLGDLDALGMVRFIADQVWDAVTERTSVLRRFGEGDLRDREWHLALFEDREKHVLEGLAKRLRKAGEPDADAFAVFNDAQDHVLRLARVHVERVLLEAFTEAVAEAPDGLRDVLGRVCALFALSTIEADLAWFLGHGRMTPSRAKRVTSTVNELCRELRPHALFLVDGFGIPEEWLDAPIAQGAEEQRQDAMHSHDETLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGB3</accession>
    <name>A0A010YGB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="33466" checksum="9CC7DE0C7B04B51A" modified="2014-06-11" version="1">MEIAFPVPGYTMLSVLGSGGFSTVYRALQESIGREVAVKIDHRILLDEADRARFRAEVRAAGQVSGHPNVIDIHDAGITVDGRAYLVMELCPAGSLADYLRQHGPLPPDRVLDIGVAIADALAAAHRYGVVHRDVKPANVLYDRYGHPELADFGLAARYDPTTESMSTLEVLTPAYAAPEMFWSRRPTPAVDVYGLSATLYALLSGRPPRWPLAEANPTDAEIAALHSAPIPGIEGVPDAVITVLRAGMAREPEKRLPTAGALRDALRAARDTVGNSTDRISDPGAPGADHDLADQPTARLPRLRPIVRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGN0</accession>
    <name>A0A010YGN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="40550" checksum="93E2DE32E8C90942" modified="2014-06-11" version="1">MFERDELGADPGAVKPLLAILERLVELPTVSGNLAACEEGLDFIGEFLAERGLVVRRFDQDGFGALVATVRPTLSPAVMLTAHLDVVPGPEHLFTLKRDGARAIGRGVFDMKGAIAAYLTLVDELGPDLGQYDFGVMITTDEETRDLGVKLLLQEELYRPRVAVLPDGGDNWQLEEVAKGAWRVRVSTYGVPVHGSRPWTGESASFKLLDLLGDIRRRFPIEDPHVDTLNISFLRAGTAPNQLPDQAEAVLDIRVMGPAELAAVERDVAEICRRHGADLELLVLFPPVKHDLADPLLAEFARSVERVTGVTCGSCLSFGSSDAAQFATVGVPCAVTRPIGGGHHGDEEWVDVASLSQLVPVLRDYLTRVAHSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGP4</accession>
    <name>A0A010YGP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A/acetone carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848088.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.459"/>
    <dbReference type="HOGENOM" id="CLU_002157_1_2_11"/>
    <dbReference type="OrthoDB" id="327092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="206"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="676" mass="71809" checksum="05EBE19ACE842A39" modified="2014-06-11" version="1">MARRLRIGIDTGGTFTDVVAIDEESGRLVTTKTPSTPSDPAEGFLDGVRKVLSLIGDESEVTAFVHGTTVATNQLLEGKVGRLGFITTEGFGFMLEIARQSVPDGYGNSYFWVKPPRIVPADLVKTVGGRLDHTGAELRPFDEAQAREVARWFRAQGVDTLGVCFLHAYADARHELKMREVLAEEHPDAVVSLSSDVLREYREYERAMTTLVDAAVKPRVGAYVRGISARLPEGVPFYVMKSNGGVLSAEEVVHQPITTVLSGPAAGALGAALVAGAAGFERVLTCDGGGTSTDVSVVLGGEPTLTTEGTVGAYPSKIPMIDVVTVGAGGGSVAWLSREGTLKVGPRSAGADPGPLCYGRGGTEPTVTDAHVVLGRIPPHLLGGEVPLDVPAARDGLEKLGDSLGLDLPSVAAGVLEISAWNQANALRQVTVKRGLDVRDFTLVTFGGSGSLLLCRLVDILGCASVLVPRDPGNLSAFGLLTVDVKNDYVQTLVARHSALEPSRVASAFEALETQAAAALDGEGFPRSEQQYVRTADLRYYGQAFEVRVPVEGLDLDAAREAFHDAHEQTYGYSFRDKPEQQVEWVNLRVTGVGPIRRPELVTLSPGELPAPTGTRPVCFDAAEGYQETPIYWRPDLSPGNTISGPAIIEEYGSTVPLHPGFTVVVDSYGNLVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH69</accession>
    <name>A0A010YH69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.652"/>
    <dbReference type="HOGENOM" id="CLU_014010_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="715" mass="76428" checksum="419F96A6C0F4FFAA" modified="2014-06-11" version="1">MTSFRLLGSGGRRLVRSGGRRLVRGGRTATRLVLVWSVGAGSVGALSVTLPGFDIGQPINALVVSATLSALNAIVWPFLMRFALAISVLTLGLGSFVLNGLLVYMALGEIPDVRLPGPPTGVLVAFTVSAVTGLTSSLVAVDEDEFFHRRARRRAKRRLGTPTNVPGLVMVQIDGLGHDVLQRAIRDGDAPTLARWLSEGSHRLIPWTTDWSSQTGASQCGILHGSNRDMPAFRWYEKDHGRLLVSNRPADAAEIERRHSDGRGLLHDDGASRGNLFTGDAAHKSVTLSSAGRRKGKLGAGYQGYFTNPFNAVRTLTGALVDVVREVVAATVQRQRDVRPRVPRGGVYPLVRALATVVTRDLVVEGILDDMMAGRSVVYADLTGYDEVAHHSGIERYDALAVLRSIDQQIGRLARAAEFAPRPYQLVVLSDHGQSQGATFAQRYGITLEQIVQTSCGQPSRSIEDSVTGPEGSALGFAARALRRLGPAAEHKPAMAGERVRSAEEEAAAKEGVLVLGSGNLGLVYFTEHTERLTVEQIQATYPDLLPTLVEHPGVGFLLVSTESRGSVVLGRHGAHYLDTGEVLGVDPLEPFGPHAPAQVRRADAYPHVADIMVNSLHDPQTDEVAAFEPLVGSHGGLGGPQTTAFLLYPADLPTPVEPLVGPEEVHKVLRAWLAWLGHDAYADAVAATAAVEEPGPPVEALELGYLPIGDAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHY6</accession>
    <name>A0A010YHY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_16_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="148" mass="16348" checksum="E9521B63B05673E4" modified="2014-06-11" version="1">MPMTDEQQPSVQAFRMVLLAAQRLRYLMDARLRPDGVTTQQAALLTVVTALGNPTLGEASAALATTHQNTAQLVASLERKGWLVSEPDPADKRRRRLTTTEKNAAYWAGRDPDDHAAVTEWFSMLTDEEVKTLAGLTSRLARGLETQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI50</accession>
    <name>A0A010YI50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848719.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447400_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="401"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="610" mass="64871" checksum="E1DA8702435D0404" modified="2014-06-11" version="1">MEPATPVPTIPLAAVTVDADGRVLTFPRSAELLLGHARSEVLGRTLGELIVPARLRDGTDDPLGPLYDACAGPDGEGHRELPARHADGSEIPADLLVTPLNGGGYTVVVAALAPRADVRRQSEWFHRALVGRSPVVMLVFDPDGRWRWSSPAAVRLIGPGAPSTEAAASIVHPEDFGTIRTLFAAAVDAPLPGGGRLSGAEPETVEVRLRGPNGTDWRCYALTIQNLVDEPAVEGIVIYAIDVTRAVDAERREQLHSARIDTLIGSLRVGILVEDPDRRAVMANTALPRVIGSPVPAERLIGEHTAELLPPAELFADPAALREETLRFLEQGRPASGTEFTLTNGRVIARDYAPIHFDGAVAGHLWVVRDVTDQATIRRGLEERNRVLAEVATLKTEFVAAASHELRTPLTSIATFSQMLAEEPEAPGDQRQIALEAIARNANRTLRIVDDLLTLAGLEGGTLPLVLRGVHLPDVVGEAVDAFAEHSEVTVDLAGNATGPMLRVDPARFRQAVEALLTIVATAHAGTRIDVRVTFAAAHWTVRVGSPSALAAGDHLFTTGDRGAGNALSFLIARAIVSRHGGQLATPRGGQTDAFAISLPVRPHLPEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIC6</accession>
    <name>A0A010YIC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3116960_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="50" mass="5599" checksum="F048B68D1F167E46" modified="2014-06-11" version="1">MSEQPIETLAEYARRLVDDMPPLRPEQRVAIRQALHGVGDEQHSGEETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIF7</accession>
    <name>A0A010YIF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848818.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1087"/>
    <dbReference type="HOGENOM" id="CLU_2568096_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="81" mass="7915" checksum="10038BFD1AC1AB09" modified="2014-06-11" version="1">MGVRAAAEYPIAARATVTARVSVTARVSVAARVSVTARVSVTARVSVAARVSVAALLAGRAGLVGAARLVASGRVVVSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIM1</accession>
    <name>A0A010YIM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="4" type="ORF">CryarDRAFT_1170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1150"/>
    <dbReference type="HOGENOM" id="CLU_153743_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="3">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="99" mass="11131" checksum="84EB6C6A07262B5E" modified="2014-06-11" version="1">MGFMTAPLVAPAETPSTAERPAQQKPWVTVVWDDPVNLMSYVTYVFQKLFGYDKPKATQLMLDVHQKGRAVVSSGSREKMELDVARLHSHGLWATLQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJC1</accession>
    <name>A0A010YJC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569852.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1353"/>
    <dbReference type="HOGENOM" id="CLU_021898_1_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="565"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="657" mass="67481" checksum="9F39422AECDAA949" modified="2014-06-11" version="1">MTTATVSALASENAGPGTDGTPRVAAAVTALAWLLAVGSAVLLLAARPPVNELLWFFTVDATVAAVYGTVAGLTLSRRRHPVPWLVALMALGGGVSALAMAYAALGAQRSLPGTGLAANLISVGWVPGTMAIFLVVPWLVRDHPLDRIGRAGVSLGGAVSVGFLGVNLTQPESPSPVVVLATASVAVGLLAAADVTRRRFRGPAGERVGLGWLAAGTALMALSFLPLALVGVVAAPIWFTPVLHLAAQAVFPAAILVAVLRQRMWGLDLAISRAVLGGLLTVGLVIVYVAVTAVLTRLLPGDGIAQIVAAAVVAVAVQPSRLWLQGRVRRLVYGDAAEPERAVRRLGRHLGGAQSPEELLDGLVESVGHALRLESVALEVEGVPAASWGSPTASPLLVPLRHRGSEVGVLRLTAPPGEALDARALRSLDELASVVAAGVVLARASQDLADARARLTSVRLEERRVIRRELHDGLGPSLAGIRLGLQGARNLIGSDPKAAGTLLAALQDELDGRVEDVRALSHNLLPPILDELGLEAALAELASRHAEGGLDVRVRCAGTEALEPTPAGAAYGIVAEAVMNVARHADASGCSVEVVAAADELRIEVEDDGTGVRPDAVPGVGTRSMRERAEEQGGTFEVGPAPTGGTRITAVLPLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJG4</accession>
    <name>A0A010YJG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849228.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2681498_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="74" mass="7360" checksum="3C852388B05D0FF3" modified="2014-06-11" version="1">MDLIAPMWGPLIGLLVLIAVVVGAVRMRGPGSAPMRRAMLTVGGGIVAVFLIGVAAEGCSGPADHSPGNAVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJS2</accession>
    <name>A0A010YJS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092890_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="26690" checksum="7365AD4ACEE187D8" modified="2014-06-11" version="1">MDRRGGGPCRGGGRAPAVAAAFRRAAATAAVIHWTLAPRRSSAIRLRPPSVSPSNSRGRTSAFASPRAGAASSGSRPTAHHWADSFAEKNAPAHWRPIRAASACERRGHWWRAAVAWRSPSRWAGVRRRERGCDFSTPLASQDSSRASPSSRPSRRVFGVGARSGEPNSFGLGFGGAALPVSPGLPGFLVVALLGRSASRSRLASSSGTTLVGAQASMPRRAARARTAPSLVPKSDAIFEMVVTVSRLVRAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKF3</accession>
    <name>A0A010YKF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071262_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457615" evidence="2">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="24717" checksum="5293D82AF8550787" modified="2014-06-11" version="1">MRAGLALAVLVAALAFGVPAAAEPPPSGGATCPPGEDCSVSAERPGGTRPRPRPPAPENPGPRGPVERACNNPAFCPPAEGPPPEAETAQQVALREFAKIPIKGPQIGIAPNPDGSGLVGLPVWLWTAVTPQTWGPFTATAAVPGLTVTATAVATRITWNMGDGKQVVCDNPGTPYLASYGNKASPNCGYRYSRAGTYQVTGTTNWVVDWTGGGQTGQIPQTRQTTTTIRIDELQVVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLD5</accession>
    <name>A0A010YLD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="32025" checksum="EA80F02E8F48A5FD" modified="2014-06-11" version="1">MTTLYGPTVAKRRLARRLVELRVENKYTANQVCDKLNWGRGKVGRFEANVWKRPEMSDVRDLLRIYGVPDAEREELEALAMRARDRAWWREYGDVFADDEYAGFESDARCVSLYMPLILPGLLQTSAYTEAHMNVGTKSEQWRARALEARQRRQRVLDDVDVELVAVLTEASLLYHWGTPEERRTQIRHLVAMSLRPNVEIRLLRFSDGPHPGMSSLISIFDFPGDEPGIAFLENDAAVQQLDSRAEVETYKRIFADIRAAALEPMATTVALKQLSDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM74</accession>
    <name>A0A010YM74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein CryarDRAFT_2410</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850584.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2373"/>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_11"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="26464" checksum="867F46579979739C" modified="2014-06-11" version="1">MSGHSKWATTKHKKAVIDAKRGKMFAKLIKNVEVAARTGGGDPGGNPTLYDAIQKAKKSSVPNDNIDRAVKRGSGAEGGGADYQNITYEGYGPNGVAVLIECLTDNRNRAASEVRIAMTRNGGAMADPGSVAYLFHRKGVVIVPKGELSEDDVLIAVLEAGAEEVNDLGEEFEVVSEPTDLVAVRTALQDAGIDYDSAESSFVPSMQIPLDAEGARKVFKLIDALEDSDDVQNVYANFDVSDEVMAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMP9</accession>
    <name>A0A010YMP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2578"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EHN" evidence="5">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="408" mass="44948" checksum="AD01154AE63A4272" modified="2014-06-11" version="1">MPAAIHPLVIAVPDADLDDLRDRLRRTRWPEPETVGDWSQGVPLEHLRELCRYWAEDYDWRATEARLNAVPQFRTEIDGLSIHFLHARSPRPDALPLVLTHGWPGSVVEYLKVVGPLTDAGFHVVVPSLPGYGFSGKPVGPGWGIDRIADAWAQLMARLGYQRYGAAGSDWGTSVSTVLAHRDPAHLAGIHLVPPLAAPDPATFDDLTPAERAALADLERARKTEDGYSLEHSTRPQTVGYGLVDSPVALCAWIVEKFHAWSDGDALSRDDLLDNLMLYWLPGTGASSARLYWESFATVQQWFTSATPDVVRVPTGCSIFPKENPRASRRWAERRFADIRHWNELDRGGHFAAFEQPELFTAELVTFFDLVRGQGTSSGPATVGTENEPGLGPAPRTNVSSRTTPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNQ9</accession>
    <name>A0A010YNQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851242.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2882"/>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_11"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="39254" checksum="9D074EDC2A764AF2" modified="2014-06-11" version="1">MATLRDRPEARLITKEFSLLLVAALGVFLALGMTLPVLPYFVRDLGGGDLAIGVVVGSMAVSAVMIRPFTAPAIQNWGFQRLVLLGGVAGAVATAGHAFADSFAVLLALRLLTGAALAVMFVACIARVMATAPAEQRSRASSYFSVAPYLGIGLGPVIGQPVYETFGFGPTFLLAGVLQLAGTLPMLLVTNHRDPGEKVPRFHSAALWPGAVLALGIIGVVAFNAYVPLYVDELRGSNPALMFLAYSGVVLAARIFAGGLPDRIGAVRAGTLATTGVVIGLVIIAAAPSPLWIYVGILPFGAGIAFQYPGLMALTISRVSEAERPAAVSTFTMFFDVATGLGGLVVGQAAALGGYRAAFAAAACCSVLGLILLRTVVAKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNT5</accession>
    <name>A0A010YNT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851280.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2912"/>
    <dbReference type="HOGENOM" id="CLU_020336_31_2_11"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="31814" checksum="BC15E4E45D003146" modified="2014-06-11" version="1">MDEFSILTEAADELGVGPERVPRVTRSAIETSPGRHVSVLTWGDSEPELVFLHGGGQNAHTWDLVALLLGRPAIAIDLPGHGHSSWRDDRDYGPVRNAHAVATVVERRAPDAAAVIGMSLGALTTVRLAAARPDLVRRAMLVDATPGSRDAYARMTDRERGAVALTRGPRTFDTLEEMVDAAVAASPRRPASAVRRGVVHNTRQLPDGRWTWRYDRSDPTLTDAGALLWDDLATLTMPTMLVRGGESAFVTDADAREAQRRLPTLRIAVVEGAGHAVQSDRPAEMASLIREFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPE3</accession>
    <name>A0A010YPE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_2_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="779"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="846" mass="90507" checksum="B616EE916D0F6ACF" modified="2014-06-11" version="1">MGARPMIRAELLESGRAETLAALAQALSELRTGRGGVVIVEGPAGSGRTTLLRVVDEAADAAGITRVDAGPGLPLSLYGLARSRRRTAESSEPHGAIVVCIDDVEHCDATTRRVAELAPSSLGDTAVLWVVAGDSIGPGIRAHPADRRYRLGELSRGDAETLALRVRSGAAPRVLDTVPRFPRYVIETAKRDTGRGWPEALLDDLPPEHHPALTAAAVLGLSFSPEDLAAVLDRPIGAIVAPLLAAVEIGVLVDDGPDLRFSHRVVQRMFAAPGADDDLVSRAVTTLVRDESVTRLVAVLREQGVPDLAPAVLRDLSTLVARRDLPTAALLARREAAAARSPADIDEATARAMSYSVQSGDPAAAAELVARLGEDHPPAASFALAELFFSSWTEAAQDLAERALSRPATADQHARLEAVRMICRAYRNLFDPDEIAQVTDLAAGAADARTTALVDLARTLSVSAQGDLVEALRHASTASEIPTDRSHGPEWWIGSIFRAKLLADLGRLDEAIHVLDTCAHEAERRSHVFAVPPLLMVRATCEIEAGRLTDAAAGLRAARQLGHLIGPPGRIETNTVNLLVRIAHLRGNTSDLNEFRPILEQRLAADSARRATAAVGLLVAVEATSADEVAEWARLAEGLDGHSRYAIARGVTDEILRLRILVRHGLSAHASQLGTFLTELASRTDAPLPNAAALHADGVMARRAETLRAAREAYRELGRPMLTAQASEDLADATADPAERAEALREARAQWFACGAYRETARIDKLLRSSGLRAVTAAEPELGFGLTPSEERVVREVLAGRTNRAIANALFLSPNTVAVHLRRIYAKTGVRNRAELAELVRNRDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQX9</accession>
    <name>A0A010YQX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852522.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1632627_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458825" evidence="1">
        <location>
            <begin position="33"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="162" mass="16785" checksum="F88E31D043A37C35" modified="2014-06-11" version="1">MSRARWRVGGSVFTVAVLLVGTLVAVSSTSRRSVESTVTYAGVRRLVVENTGGSGTLAVRGGGTRVTVHRRASWSLSRPRLAARRSGDTLTLTGDCLGDGVITVRVNCAVSYEIDVPPGTRLVAATAGRVDVTGVTGPLDVTAPGPITITGARGPVSTRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR59</accession>
    <name>A0A010YR59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852618.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3849"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="4">
        <location>
            <begin position="99"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1016" mass="108473" checksum="934180A09EA7011F" modified="2014-06-11" version="1">MILRCRCLGSLEVHGGDQWRPVRGARARALLAVLVRHRGEHVPARRLADEVWDGRPPASAGTLIRGYVSALRRAFGADGARVIVGSGGGYRLDLPPDAVDVDLFDALCAQGGTALRRGDPEGAALLLADALALHRGPACADVPRTRTLTAFAEGVEERRLVAVEARIEAELACSRHTEVLGELRRLVTEHPNRERLLAQWMRALHAAGRRAEALDVYLAAHKRLVEQRGIDPGPELRAAHRTILAAEDAPRPQARPGRGGTGWSPPSQAPAGIADFTGRDAELARCLAVLTEPGARALRVVAISGRAGVGKSALAVTLTHGLRAWYPDGQLYADLTGETHRAVEPADVLAMFLRAVGVPGSAVPERTDERAALLRSIVADRRVLVVLENAPDERRIRALLPGGAGCAVLVTSRGRLSALEGAHFVELDVFTPEEALTLLERVVGADRVHERIDAARRLLDLCGRLPLAVRIMAARIASAPRTPLEWFAERLADERRRLDELRLHDLDVRAGIGAGYALLSSRQRRVLRRLAVLDVTAFPAWVVALVADVDERAADEALDALVGHRLLDAAGPDDGGRPRYRFHGLVRLFARERAAADPDLDPAAVLECAVRGWRALAEQATTRLPARTLAPIPSPARPGPVTDEAIREPFAWFDAERESIAELVGQSVELGRADLAWPLAAAAHPYYELRDYSEEGSRVHRSALDACRAAGDSLGEAVMSRNLADLYISKPGSDISEKLAHAERALELFRAAGHAPGEADAGYLAATVHRVLGATDQVEACLDASLAVAGSVGYRLGEVHVWQLRGILRRQQGRQADAIAAAGRALTVARELGSSRDVSVLLGLIGLAHRDRGEPGPAEAALAEAVTIAEETGDPVQLAFLCAHLGGLYVESGDPRAQRLLDRGLALSTGSRSEFGEAMALDGLGRLALRSGAPRRAVAHFTDAVALHRRAGNLQAEAKALAGLASAWLGAGDPVAARDTGLTARALFRRLGNETEAGLLSVVIGPQPRADSVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRH6</accession>
    <name>A0A010YRH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570663.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3964"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="27236" checksum="8A64CF2612343BCD" modified="2014-06-11" version="1">MTDPVLSARGLVKTFGRVVGLDGVDLDLYPGEVLAIIGDNGAGKSTLIKCLTGALVPDAGEIHVDGQPVQFRRPQDAREAGIETVYQTLAVAPALDIASNLFLGRERRRPGFLGSVLRMVDKPGMRDDAAKALTDLGIGTLQNMAQPVETLSGGQRQAVSVARAAAFGSKVIVLDEPTAALGVKESNQVLRMIREVRSRGLPTILISHNMPHVFEVADRIHIQRLGRCAGVITPDSHSMSEAVAIMTGATTLVESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVM7</accession>
    <name>A0A010YVM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ORF">CryarDRAFT_0221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847693.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.208"/>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_11"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="570" mass="63258" checksum="2C9290052B0DB97C" modified="2014-06-11" version="1">MSFIRNPQRPSGMPIHRYTPFTPIDLADRTWPSKQATEAPLWCAVDLRDGNQALIDPMSPARKRKMFELLVAMGYKEIEVGFPAASQTDFDFIRQIIEDDLIPDDVTIQVLTQSREELIHRTFDSVRGAKQAIVHLYNSTSTLQRRVVFGLDREGITAIATNGARLCQKLAESMGDTFIRFEYSPESYTGTELEYAAEVCNAVSDIWEPSDDRPVILNLPATVEMATPNVYADSIEWMNRHLAHRENIILSLHPHNDRGTAVGAAELGVLAGADRVEGCLFGNGERTGNVDLVTLGMNLFSQGIDPMIDFSDIDEVRRTVEYCNQLPVHERHPWGGDLVYTAFSGSHQDAIKKGFEWMERDAAAANTPVDDFRWAVPYLPIDPKDIGRTYEAVIRVNSQSGKGGVAYVMKTEHQFDLPRRLQIEFSQVVQKITDNEGGEVSPEAMWSVFRDEYLPNPDNAWGRLALRGYHNVGDQVSFDIVLDGVEKTVEASGNGPINAFVTALDAAGIPVRLLDYTEHTMSADSGAQAAAYIECAIGEDQVRWGVGVDTNIVTSSLKAVVSAVNRAYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZH5</accession>
    <name>A0A010YZH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1668"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="448" mass="45040" checksum="20AEFEC494C53C2A" modified="2014-06-11" version="1">MSIVVQRRLALTVSAAGAMIVALDGTILLMAQPSLQRDFDATVARIQWTSTAYLVAVAALLVIAGRLGDRYGHPRLFLVGVIGFGAASAGIALASSLGWVIALRAVQGGFGALLQPATLALLRLTYPADRLGTPIAIRTGAIAVAAGSGPVLGGFLVAQLGWRAAFWVNVPIVVLIAALTVAVRTPAPERDHASRLDLTGAGLLATALALLVHALAEVPGRGWAAPATLLELLAVAGVVVVLVRHERRTASPIVPPAVARSASVIASVVLLLLISAGLFGALFTGTFYLQDVLRLDPFTTGLRVLPLTALMVLGAPVASIALRRQGARRTATVGTVLVVLGIAALSRVGPDTPTPGLAAALAVIGAGYAAVMVTATGTVVGDAPPGYAGLVGGLKQTAMNIGPTVGTAVAAGAIGSRISTIGPALLLLGAVAALGLGPASWLPGRPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0A9</accession>
    <name>A0A010Z0A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2698424_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="73" mass="8132" checksum="FE379F12EFBD3A49" modified="2014-06-11" version="1">MARHEQVLALWCALTGHDPEWFEEPEREALLARTEIAKLAEATDAVLLYAGRSVCRGTSLPLERWLAAARLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0T4</accession>
    <name>A0A010Z0T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretory pathway, component PulF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570010.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2119"/>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_11"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="83"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="287"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="421" mass="44789" checksum="84F38814C75868CA" modified="2014-06-11" version="1">MTATLSDPSRGSANKIFEYQSVDTSGKRTRGKVNAPNTGAAIQILRQQGVVPLSVTPAGTGLKTEISLPGLGSRTTLRDLSVFSRQFATMTSSGMSLLRCLSVLEEQTSRASLRKALTEARVDVEGGTPLSDALGRHPKVFPTLMVALVRAGEAGGFLDDALERVAINFEKDDALRGKIKGALTYPVIVLAFALLMVAGVLIFIVPVFENMFRQLGGTLPAPTQVIVTASHSLIWSGPLSVGVIVVGTVVVKRLLATRPGFRLAFDRLKLRMPVVGKLVSKIAISRFTRNLGTLLGAGVPVLQALSVVGATTGSAVVTTALLDVERGVRDGAPMSSRISQHPVFPQMVAQMIEVGEESGQISQMLDKIADFYDREVDTAAEALTASIEPIMVLLMGVIVGAMVICLYLPMFTIYQNIQGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0U7</accession>
    <name>A0A010Z0U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminoglutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850221.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2129"/>
    <dbReference type="HOGENOM" id="CLU_012358_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="440" mass="46201" checksum="DFB48753F09342AD" modified="2014-06-11" version="1">MTGAYWAEYAWLPEGAAAGVLIEVADGRITGVTAGVRAPAGATRLAGLTLPGLANAHSHAFHRGLRGRTQAGRGTFWTWREQMYALAATLTPDTYYALARAVYAEMALTGITCVGEFHYLHHAPGGTPYADPNAMGEALITAAADAGIRITLLDTCYLTGGFDRPLEGTQLRFGDTTADRWAGRVSALRPGEGHVRIGAALHSVRGVPREQLGPVAEWAAAHGAPLHVHLSEQPAENEACLATHGVTPTRLLADAGALGPRTTAVHATHLTPDDIALIGTTRTVTCACPTTERDLADGIGPIRALHEAGSPVSLGSDSHAVIDLFEEARAVELDERLRTRERGHWRAAELLRTAFAHDSLGWPDAGALRVGARADLVTLRTDTIRTAGFTPTTAAETAVFAAGAADVHSVVVDGRAIVADGHHTTVDAGRALTDTLRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2H1</accession>
    <name>A0A010Z2H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2703"/>
    <dbReference type="HOGENOM" id="CLU_044864_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="28504" checksum="863F9BA29263DE2D" modified="2014-06-11" version="1">MIRPVRSYLYVPGDRADRLLGARTRGADALIVDMEDAVAPANKQAARELVADWLTPEPGPQVWVRINAESTTDDLAAVVRPGLDGVVVPKADPDVLAAVDARLTALGSDAAVLPLVESAAGLVRVAEIAAAPRVLRLGIGEADLIADLGLRPGPDRAELAPVRLQVVVASAAAGIARPVGATSTDFRDTDAFRESARTLARQGFRGRTAIHPAQVPVIHEVFTPTDDEVATARDVLDRFDAAGGGGAVDARGRFIDAAVVRSAREVVALSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2R1</accession>
    <name>A0A010Z2R1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, G6PDH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851139.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2789"/>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="34220" checksum="DFA43D21CB9E1083" modified="2014-06-11" version="1">MVSIGYFLSCEEFGPRELIDQARKAEQAGFTRLWISDHFHPWNGEQGNSPFVWSVIGALSEAVSLPVTTAVTCPTVRIHPAIIAQAAATAAVQLEGRFVLGVGSGEALNEHILGDAWPPAGVRQDMLEEAIALIRELHTGSIVTHHGEHYVVENARIYTLPSEPVPIYVSAFGPQAAELAAAVGDGFCTTQPDASLVKTYRDAGGKGPAQGGMKVCYAPDRASAVKTVHRLWPNEQLPGQLAQELATPLLFEQASELITEELIDSAPLPLGPDLDDHAKSVQEYVDAGFDEVYVQQIGPDQDAFFAAWQKDVLPRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2R6</accession>
    <name>A0A010Z2R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851143.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2794"/>
    <dbReference type="HOGENOM" id="CLU_060110_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="30229" checksum="3339EF4615C93995" modified="2014-06-11" version="1">MTATGIVLITRDRRERTLRTLGVLTALPQRPPIVVVDNASADGTADAVRHHHPHVRVVRAHKNHGAPARTLGARMLATPYVAFSDDDSWWAPDALTRAEEHFARSPRLGLIAARTLVGPEQTEDPLNEVLATSPLGTAADLPGPSVLGFLACASVVRRNAFLAAGGYSELLHFGAEETLLAIDLAAAGWGVAYCADVVAHHHPDRGGRLGREIRLRRNTLLTTWLRRPWPVVAADTAALALAARTDPGARRVLAAAAPKLLTAMGNRRRLPGRVEHDLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK55</accession>
    <name>A0A010ZK55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ORF">CryarDRAFT_0059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.57"/>
    <dbReference type="HOGENOM" id="CLU_052662_0_1_11"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="45110" checksum="C90F8B8CF265D6E7" modified="2014-06-11" version="1">MSDHELLRTDRPRPYVDSEVGRLRTVMLHRPGPELRRLTPRNNGSLLFDGIPWVARAQEEHDAFAEALRAHDVEVLYVDQLLAEALTDPGARKEISESLLGDRRWGDTLRRRVAEHLQELDAESLAATVISGLAHEELRNGTGLTYQLMNEYDFVVEPLPNTLFTRDSSVWIGGASAVTSMAMPARLRESTITGTIYRWHPRFAGSPSLYGRDLEPLEGGDVLLLAPGVVAVGVGERTTPAGAERLANRLFADGRASTTHTVLAVPIAQQRATMHLDTVCTMVDLDAVVAYPAVADTLMAYRLTAGTDGEPAVSGPVPFLAAAAEAMGLERLRVIPTGLDPVTAEREQWDDGNNTLCIAPRLAVAYERNVETNAQLEDAGIEVIRIPGSELGSGRGGPRCMSCPIVRDPLRTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKQ0</accession>
    <name>A0A010ZKQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859964.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.242"/>
    <dbReference type="HOGENOM" id="CLU_042257_0_0_11"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="165"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="35658" checksum="4CE7E8B2DFE330E8" modified="2014-06-11" version="1">MLAPVAWRTPPEHYGPWESVTSLLTEGLVARGVDVTLFATLDSRTSARLEGVCPHGYAEDPSMDGRIWEALHVSHALAASERFDLLHSHLDWLPLAFAAHVRAPLVTTVHGFSDRRILPAYQRAGAAYVAISEADRAPGLDYVATVHHGVDLDDLPFRPDAGEHLVAFGRIHPDKGTAEAIAIAAATGRRLLICGIVQDEQYFAEQVEPHVDGDRVTYLGSVGPTRRAEVLGSAAVLLHPIAFAEPFGLSVVEAMSCGTPVVAYPRGSMPEVVDVGVTGYLPRDRDEAITAVTAAARLDRAAVRTRAAERFGSDRMVDDYLRVYQRILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL46</accession>
    <name>A0A010ZL46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.388"/>
    <dbReference type="HOGENOM" id="CLU_008023_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28005" checksum="DC2A5E803ECC85A2" modified="2014-06-11" version="1">MGVLNVTPDSFSDGGRYENLDAAVSHAMELAGQGAEYIDVGGESTRPGAERVDADVEIERVVPVIRELASAGVAVSIDTTRAAVAEASLRAGASIVNDVSGGLADARMGAVVADAGCPWILMHWRGHSRRMQSLARYGDVVTEVRDELSARVDAALAAGVSSDALILDPGLGFAKTGVHNWELLARLDVLQALGFPVLIGASRKSFLGRLLADDEDKPRPVDEREDATLAITVLSAQAGAWGVRVHEVRASVDAIAVLEAYRRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM23</accession>
    <name>A0A010ZM23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase, class III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848481.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_11"/>
    <dbReference type="OrthoDB" id="1859760at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="36737" checksum="65995B8378A34D4A" modified="2014-06-11" version="1">MDITVAAVTAEKTFELRPAQLEEPRADEVLVRLSAVGICATDLHFATFLPTNAVLGHEGAGVVEAVGAGVSGVEVGDQVALAFTSCGVCKQCRTASPSYCAQFDALNFAGARSDGSSALSIDGQPVYGHFLGQSAFATHAVVSARSVVTLPDTADLRTAAPFGCGFMTGAGAILHTVKPGPESAVAVFGAGAVGLASVMTAAAAGAQTIIAVDVSPSRLQTAQEVGATHVLDSREGDVVERIRAIVPDGLDGSVDTTGRADVVKSAVTALHTRGTCAVVGVGPSENVEVEWRTLLNGRTVTGVISGSAVPQVLVPQLLEWQRAGRFPVEKLMAHYAFADINEAAAATKRGDVVKAVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMI7</accession>
    <name>A0A010ZMI7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">CryarDRAFT_0935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848660.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.919"/>
    <dbReference type="HOGENOM" id="CLU_095787_1_0_11"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14362" checksum="EFEEE7879DCF58A0" modified="2014-06-11" version="1">MFKGFRDFIRRGNVVDLAVGVVIGAAFTGLVTQFGNSFLKPLIQLITGGEKVGGTFEINDVKFDYGAFITAMIIFVLTAAALYFVVVAPMNRLNELRRRGQEPEPAAPSEEIVLLTEIRDALRENGGGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZML9</accession>
    <name>A0A010ZML9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">CryarDRAFT_0977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848695.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.960"/>
    <dbReference type="HOGENOM" id="CLU_075939_1_0_11"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="21849" checksum="445C90BA79BDA5A3" modified="2014-06-11" version="1">MSEVRIAAEPRTEFGKGGARRTRRAGKIPAVLYGHGQAPRHIALPAREFTNAIKHGANTLLTIEVDGGKELALAKAVQRDPIKQSIDHVDLLLVRKGEKVTVELAVVLAGEVERGGRVNQDLTSLTVEAEATNIPDGVEVNIDGLQIGHQLLAKDVALPKGVTLITDPEAAVVGVVAQQSAAQAEAEIEAAEAEAGIERDEKQTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMX4</accession>
    <name>A0A010ZMX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848808.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1081"/>
    <dbReference type="HOGENOM" id="CLU_056917_1_0_11"/>
    <dbReference type="OrthoDB" id="1559784at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="170"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="31877" checksum="11BE4C998886C924" modified="2014-06-11" version="1">MSTVGALFGLALAFGLVLVLRGGPPARHPRLDDRLAPYVGRPDVSRAALRGGGRPGPRPREWVVAGRAVGDVVAGWIDRLLPGGAGIRRRLSAAGRPGSVPAFRAEQVRWAAAGLLAGAVSGGALGGGTGLVLLTPIGALAGGLGRDWWLSVQVRRRTEALRAELPVIAELLALAVTAGEAPVAALRRVSVACRGELGRELTRVVDESRSGAGLTTALEELAARTALEPLVRFVDGFVIALDRGTPLAEVLRAQASDVREAGHRALLEAGGRREIAMMVPVVFLILPVTVLFALYPGLVSISLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP36</accession>
    <name>A0A010ZP36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of Mn/Zn ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="28523" checksum="888F54BFA3F4F2E9" modified="2014-06-11" version="1">MPVNESSPVAAAEHATVVLGERPVLRDVSLSVTAGEVVALLGSNGSGKSTLVRTLLGLVPLAGGSVSLFGTPTARFNDWQRVGYVPQRAGAATGVPATVREVVTSGRLARRGFLRFASAADRAAVTDALETVGLADRARERVSTLSGGQQQRVLIARALAGSPDLLVLDEPNAGVDAASQRAFAETVERLVERGTTLLVVLHEVGPLADLITRTIVLDHGRIAHDGAPWADGHVGGYWIDTDRHHVHGNPTASPHGEWDGVPDHAGPAKAVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP48</accession>
    <name>A0A010ZP48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional attenuator, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="114"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="39417" checksum="CA58D88D0246BC4F" modified="2014-06-11" version="1">MAVGLEEARSAKPSEPPGPASARFTSLPPRKPKAPAWAKACIALGAVLMVLAAGTLTAAYGVTYRYESKLKRTDILGDLSEKQSTYTEGPLNFLILGSDDRATDPSFAATEGLRSDTIMLAHVDKTLKKTYIVSIPRDSYVDIPASDDGKWQGGKDKINAAYNFGGPALTAKTVQNLTGVTLNGAFILDFSSVRKLVSIVGGVTVCIPFSMSSIHTERKWKKGCNFLTPDASQDFMRQRKTVPGGDFGRMQNQQRVILAVAKKMTSKGVVTDPKKLDKLLSTVAESVTVDQNLNLPDLALGLKNVRPENLRCTTLPFLTDDLQTPAGSSVELDPVKGEQLYAAMRDDTMDAYLAANPPANAGQAGACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP67</accession>
    <name>A0A010ZP67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23768" checksum="0F4119C792C49B8F" modified="2014-06-11" version="1">MLIDRNPLPDGIDERLRRQLSFIAEVDQLKTVLRASPLAAAERRENDAEHSWHLALMVLLLAEYADEPIDVGHTMRLVIVHDLVEIHAGDSPVFDPAAVVGQREREEAAADRLFTLLPDDQATHLRALWDEFEAGATPEARFGKAMDRLEPMLLNWLTGGGTWHMPGATESTVRARESGVVAGSTSLGAATGRLVDEGIRRGWIRPDGPDLEPSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPN5</accession>
    <name>A0A010ZPN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847671.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.197"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_11"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="32681" checksum="7A139A6324A3477E" modified="2014-06-11" version="1">MTSLLTRKKDRIDDLAERGESLSRDAFRRLSRNPVAILGAVIVLLFVLVAIFAPLLAPKDPYVRYLIDEVRQNSPLPARDGFPLGADQNGRDVLSRLIVGARQSLIVGVVATLVGLIVGMLLGGVAGAVGGWVDTVLMRFVDILLSVPSLLLAISIAAVFKSANQWTVIAAVSIVSVPIFARLLRGAMLAQRHADHVLAARALGVQERSIVLRHMLPNSLSAVIVQATLTLATSIIDAAALSFLGLGDADPNRAEWGAMLGDAQTYFDIQPSLAIWPALCIIVVALGFTLFGESLREALDPKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPS4</accession>
    <name>A0A010ZPS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847727.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.227"/>
    <dbReference type="HOGENOM" id="CLU_045498_7_1_11"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="245" mass="24502" checksum="A33DFC6A24A8DCC6" modified="2014-06-11" version="1">MTFVLLVVAGLGAGLTGTIAGLASLASYPALLAVGIPPVAANVTNSVALLANTVGAVSGSRPELTGHWKRALELAAVSVFGGAIGGALLLWTPSDAFEKIVPFLIAGASIAILVRRPGEAAALERRPGWPTLFSIFLIGIYGGYFGAAAGVLMLAVLLAIGTGTLARAGAYRNVVLGAANGVAAIGFALFGPVVWSAALPLAIGCLVGARIGPIVVRHSPSDALRVVIAVAGLGLAGWLGYDAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPV0</accession>
    <name>A0A010ZPV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain containing CoxE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1760"/>
    <dbReference type="HOGENOM" id="CLU_272484_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1359" mass="137730" checksum="9535AB96D9C9CF49" modified="2014-06-11" version="1">MPSAEEGSPSLAGPAVSPGPIVSEGVAASAGVAASAASVGVVDPAVVVEELAGRGVPFLIGVRHHSPALAAVVPALLDEAQPDVVLVELPAEFAPWLPWLADPQTVAPVALAGSDGADGTLAFYPFADFSPELAAIRWAAERGVPVVPCDLPLSDRAWTSRGAIEPDAEGLEGFGAEGPAGPGAGRTDAAGPGATGPGAGGGGPAAGGVAWPSMAEALRAGNTGRVDDDLWDRAVEARAPGSTPEAVRRAALLVGWALRTDALHDGGIDPVDLRREACMRQNVTDAVAAARANGHEGRVAAVIGAFHAPALTAQAPTHPTVPAGGTAAPTGAAGRTSAAAEATAALGGTTAPGGPATAGGTTASEGATATAGDTVAAATTATTGTAGTAGTAAAEDTAAGAGGATTAAGTTAAGGEAGALTGTTAPGSGSGRRAEIVTSLVPYTFALLDERSGYPAGIRDPQWQQSVLTAGGDADAIRDAAVAALVGITAQIRASGHPAGPGEAGEAVRLAAGLADLRGLPAPGRSELVEAVQSVLSQGELLGRGRVVAAAMEHVLVGDRRGRVAPAAPRSGLRTAVERDLAALRLPGAGEPTRDLRLDPLRSDLDRRREVTLRRLGVCRVSYASTTEVTGVGGGDGLTTRWQVGWTPSTEAALDVAGIHGVTLAQAAEGALRARRRRHVDAGGPTAGEAVELFVVAAECGLVRAAAQYLTALAAIAPATGTLPELLSALAALDRVRLGHVPGLPDAVRPQLGDLVAVAADIEAAAVRQLDGLAGSTDVADAHALAALAQRNDFGLRLVDALERLSADGAPLIAAAASATRVLLGVESPEWLGRRLASWVDGATDPDRRRALQGRLTGLLAASGPLLETGGAVFEGLFERVESLADQEFLVRLPALRGGFTVLSPAARDRLLTTVTDRLGDPRADIGDVADPRSLLHHLLADRSAREALIRLGLPLPTAATPGPATTGDTATTGNTATTNDTTTTNDTRPGRAPGELAIVDRWRLILGRPGVQNPQGRRYAAALDELYGAGRGEGAQDDADARAGRGASYPTAREWSDELAALFGPGVREEVLGRAVEAGRTDAALELDPASARPSVELLQTVLSLVGGVPEATLARLRPLVARLVAELTAQLATRIRPALTGLASPRPTYRPGGPLDLARTLRANLATTHRSPDGRVTLVPERPVFRTRARRSVDWRLVLVVDVSGSMEASVVWSALTASVLAGVPALTTHFVAFSTEVIDLSDRVDDPLGLLLEVRVGGGTHIAAGLRHARSLVTVPSRTLVAVVSDFEEGYGVGGLLAEVRALAESGCTLLGCASLDDAGKPRYSVPIAQRLVAAGMPVAALSPVELARWVGEHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPZ5</accession>
    <name>A0A010ZPZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847779.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_1_11"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458041" evidence="4">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="29"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="19688" checksum="85ED4AED9E5CBC2A" modified="2014-06-11" version="1">MKRLLAVALVVLLAGCSSSGPADVEPKPTKAAFASSKFAACPAAAGSAPADSPLRSVEPLLCMDPSGKKVTIGAPTGHPVVLNLWGSWCPPCGKEMPAFVRLAASAGDRVSVVGVNTADDASRAVAAADELDVRFANVFDRGEEVRKALGVNALPATAFVSAAGEVVHVHRGTPLTDATLNALVRQHLGVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQM5</accession>
    <name>A0A010ZQM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar hook-basal body complex protein FliE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147249_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="12625" checksum="EF721E1DAA6E75B0" modified="2014-06-11" version="1">MTTPIGSIGSFSAVGAIGAGGASDPIAPIAVSGIGMSGTSSALPAAGNTEETSESAKGFAAQLADSLQNLQALQTRKDDLAVKAATGSLTDVHDYTVAATEAALATQLTVAVRDKAVAAFQEIMRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQU1</accession>
    <name>A0A010ZQU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570006.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_1_11"/>
    <dbReference type="OrthoDB" id="2059436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="80" mass="9142" checksum="F23CCE72FD62E428" modified="2014-06-11" version="1">MTPPRKPTLEELRVDVDAQSWQRSGTGRGVIEVAFVDALEERWVLMRVAGDPDGRVLVYSRFEWECFVDGVRKGEFDDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRK3</accession>
    <name>A0A010ZRK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848622.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.872"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_11"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34149" checksum="18DD6A12F8AF9620" modified="2014-06-11" version="1">MVAKIVVTQPVHAEQVQRLRDAGHEVVTLDSPRGLSAAELIEHTKDADALLSQLTDKLTEEVFAETRLTIVATIATGFDNIDVDAAQKAGTIVTRTPDVLTDATADLAMTLMLAVARQIPESDASTREHGTGPFQLLREPMGIDISGATLGIVGLGRIGEALAHRAHFGFGMKILYTARSAHPAAEERFGASRLPLGQLLAESDVVSLHVPLNDETRHLIDRETLTLMKPTAILINTGRGPLINERDLAEALRTNQLAGAGLDVFENEPDVHPDLLAVGSRAVLTPHIGSATAKTRRAMASLAVDNILAVLAGDPPLTPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRN1</accession>
    <name>A0A010ZRN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120348_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="172" mass="17819" checksum="A5FFFFC584D4ED30" modified="2014-06-11" version="1">MLHRWPTVLALACAALTLSDGAAEPGVGVALVVAAAGYVALAALDRRALTWPVVVVLFVGVVALRAFEVPELPVLAVIAVVGSAVVAVRRRERWHLLQVPVGLMGLAVFVVALEVPTAAGAVVVAVGLLGHAAWDAVLWRRDSVISRSFAEWCGVFDAVVAVGLLALVATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRU7</accession>
    <name>A0A010ZRU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494106_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="551" mass="55851" checksum="2D39A1A86C247161" modified="2014-06-11" version="1">MDGGLRGPARSHAGRMARTSHRPAELVGQIFRGSEAVRRGLLTRSQLNGAAWRRVFRDVYVDAELADSHRLRCAAAGLILPAGAALTGRSAACVAGLPIGEPTDPVSVIVPPPNRLQTRGIRARQATLSAAEIQRYPNLGPTPPPPDGPPGPPPTDGSPGPTPPRSVGLNSAGRPAGPTSAGIPTGLNSAGIPAGLNSAGVPPGPTSASVPVHSESAGVPAHSESAGAPAHSESAGGRPGSTPAAGPSGPISADRLPSLGPATGLDPLSGLGSITALGPITGLAPLAGLGSPVGPDPLVGLSSLAGLEPLAGLAPATGLDPSAGLRSAAGLRPAARLGSAANLRSAADFGSAAGLPSPGPIAGPGDGQPCPDLVVLVASETATLPVTVPARTAWELARETDVPAAVAGLDLLLNHAYVTASELQSLVDARPRTRAADTIRLADARSRSPEESVLRVKLVRAGFPHPVPHHAIPVGDRRTSVDLGWPALRVGANFYRDGEHYRGDQPRRNALADARWTVILAGAEELDDSDRFARFCGVLDDALRRRRDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS56</accession>
    <name>A0A010ZS56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2582"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="22800" checksum="196F35B913409619" modified="2014-06-11" version="1">MLAEDSALLRVGLERLVTDEGHEVVASVGTADELLVAVARDRPDVVVVDVRMPPTHTDEGLRAALRIRAEWPDVGVLVLSQYVEKRYATELLGRTASGIGYLLKDRVVRVEEFLDALARVGEGRAAFDPEVVRQLLARPAYPVSALTVREREVLARMAQGQTNGRIGTELSISQSAVEKHVNAIFEKLGLSAEGGYSRRVLAVLRHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS73</accession>
    <name>A0A010ZS73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2604"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="24228" checksum="06065CCFBAC9F6C8" modified="2014-06-11" version="1">MQPENTAQCATLHIGKNARLTGVDGLRERKKTAARQALHEAAVRLALEQGLDRVTTEAIADAAELSRRTFSNYFPSKEDAILHGDVERLREWLDALRERPRAEPPWCALRESLRALYGQWADPNLARATAMRALRQHPSLVARQSVIYGAFERDVARVLQERSGTDTPDARRATRVLAAAFLAGLRVATALWIEEPEVRALIPTIDEVLDQVGASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSP1</accession>
    <name>A0A010ZSP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301118_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="10785" checksum="ACFAC1B5D85618AF" modified="2014-06-11" version="1">MASESGTGTDGGPVAGRPEYPGGPVAENIFPVAPDPTPVATPVTPVSQRLPVGLQIGVALLFLYLVLVYFDRRFLLVRRRPEAEPQDVGLDLVQDHVHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZST0</accession>
    <name>A0A010ZST0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1298"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="71"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="312"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="587" mass="61678" checksum="49D79EA93C070F22" modified="2014-06-11" version="1">MTRPADRDPPAPSDPAGDPAPIDRVTGEPVPAEDPAADGGPMPVDDPAADRRPGADGPAPIDPPGLGPAVLELVGVSKAFGPVQALSDVSLRLLPGQVHCLAGENGAGKSTLIRVLTGAIRRDRGDYRIDGAEVASATPAALRAAGVQAVYQELSLLPHLSVAENLYMGRLPARRGLLDSRRLRRSARLALADVGLTDLHPDTPVERLSAATKQLVEIAKVLTAEEVKVIVFDEPTTALTESESARLLDHIRRLREQGVAMLYVTHRLEEMFEIGDQVTVLRDGGLSETGPMTDYDENRLIAAMVGREVTSLYPEEARDAGTPLLRVRGLRRTADGPSVDLDVRAGEIVGIGGLLGSGRSELLLSIFGAERIVAGEIQVDGRTVRPTGPRAMMNAGLGLLTEDRKVLGLLPELSIRENVTIASLRRASRGGLLPGKAQAAEADRLLDSLRLRAGSYDQPVSTLSGGNQQKVLLARWLLTEPKVLVFDEPTKGIDVGAKGELYDVIGDLARRGLGIVVVSSYLPELIGLADRIVVLRDGAIAGELPAGASEEEVLRLASGGAAPESAPGGGPAAGGRDEGQEGDRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT00</accession>
    <name>A0A010ZT00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862394.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2891"/>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="207"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="37040" checksum="759B50C213DEACD6" modified="2014-06-11" version="1">MPSLTAEELERHRRELRVHCYRLLGSYTDAEDLVQETFLRAWTKRDTFEGRSTLRAWLYRIATNACLDWLDGKARRVLPHQLTGPSDPSVGLAPRTDVPWLQPFPDHELAAPDESGPEAVAVGRETIELAFLAALQLLPARQRAALVLRDVHGWPASDVAGALGLSVPAVNSALQRARATLRESLPERRADWRAATEPTAEEKHLLHRYLDAVRRGDVDAVAALLAEDIRTTMPPWPMWFRGREHVRRALASSWDPALEGYVGEFVMRPVGANRQPAVASWTRRPGEPAFRPFAISVMEIRDGFFTGMTAFHDPALFPAFGLPAEILPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTB9</accession>
    <name>A0A010ZTB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase (ADC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851475.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3039"/>
    <dbReference type="HOGENOM" id="CLU_100208_0_0_11"/>
    <dbReference type="OrthoDB" id="978501at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="24709" checksum="9C3BC91CE19AAE4C" modified="2014-06-11" version="1">MTSYDIAGQTVTMPVQVRDASAATILYEVDAAAARALLPGDAFRVVENEPGRAHFALVLVDYRDNDLGAYHEVGFTFFVRPASGGEDGTFITRLPVNQEFTCEAGRTIWGFPKTVERIDVENTPTSSTWALFVDGQHAFTVRTPRGGTDESPAVPMTAYSLIGGEPHRTTFTQGGRESQVVFGGEGVELTLGDGPLAKELAGLGLPGAPVVLTTWTERMRATFEVAQPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTK3</accession>
    <name>A0A010ZTK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849483.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038055_0_0_11"/>
    <dbReference type="OrthoDB" id="1907090at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="44029" checksum="2E2FE60B0A6CF04B" modified="2014-06-11" version="1">MRTPYRWLGGLRGIAQLAGLVVAAALAGQATVTYSAANDGWQGSVRQEVARSSAIQEQVRAVYGDEAPKALRIVVDERLATELDRLSADNPLAATQRDTARATADSLRAANRKYFPATLPADRQYTTDDGGADVVARLRVLRRSELDEQRAAGEPIPDPASALRDGDAAGADGLRYALGAVGASLLAALLAAVHYRARHRRRQQEVAELVEQPRQSAAGRHRQVTVVILTLWAVGAVLPLAQLVFGAEEQRSQATAARLAAVLTTDIAASTARTEFLTQGRQVAQEVGVRARARELSAESATPSEAADRRAVAAAEERASAALDRIAASMARTPRADDQLDQRMATALTSDEADWTTLIDAQNDQADRAGDWGDRSNRMVWGIVLITGFATLFGVAEWRYENVTRASTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU91</accession>
    <name>A0A010ZU91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849801.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2733246_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7907" checksum="BA97C1DA5ABFD5A0" modified="2014-06-11" version="1">MQLGQDAGGLENNPRAIVIIVFVILAGLLLNWFQRKWMKGMSFRNRVFFIGIGALILGGVFYGFVYNVNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUY5</accession>
    <name>A0A010ZUY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569997.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587564_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="208"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="465" mass="49773" checksum="0085B9F429370A23" modified="2014-06-11" version="1">MDRPEWVSGTVTSAPDQRAGRAEHNRAVDIAVFAWEWARNLSGTSWVADDRTVIVERLRLLVDQAADALHGLTDSAAAGRAIGEGVVTIGFAAPDALGRTLYLLGTRLPAELGVDPADGALPQRLASLVGAVGVGFARAAHDRTLEQQDAIRTSDLVARQRAERALRTQLAAANLPTEETTTTGTRATDDTPDTTGAGRTGRTGRVLDTGYRSELPAALNRGEVVPYFQPIVALDDERLLGFEALARWEHPVRGTLPPAAFLPDASESELFRALGQRLRTEACETAVSWQREAARPLFVGVNLSPAELRDPALVDDIRDLLDRTGLAPELLHLEITEDVSLTDADLPVLRGLAATGAQLTLDDFGTGLSRLAMLPVLPIHGLKLAGALLDPVRQLPFPAAQAGTDVLVTVTALAQRLGLTTTVEGIENIAEAGLARRLGVDRAQGWHYGHPLPARHVRAYTTWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUZ6</accession>
    <name>A0A010ZUZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852378.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3675"/>
    <dbReference type="HOGENOM" id="CLU_045951_0_1_11"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="185"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="412" mass="44235" checksum="329443F23762CFB2" modified="2014-06-11" version="1">MKLAVVGGGSTYTPELIDGLLSNAFGIDEITLVDPDADRLEVVAGFARRMVGAAGKATRITATDDLDQGVDGAGAVLVQLRVGGQKTRLSDETFPHACGCLGQETTGAGGFAKALRTVPVMRDIASRVDPDTWIVDFTNPVGIVTRSLLDAGHKAVGLCNVAINFQRNFAGLLDVDPGRVGLRHVGLNHLSWETAVYLDGEDVLPSLLAARAEELAERFRITPEHLRLQGAVPSYYLRYYYAHDVVVAEQQTERPRAEVVSDVEQELLALYRDESVVTKPEALQNRGGRHYSLAAINLVASLLQDSRDVQVVNVRNRGTLPFLPDEAVIEAASTITAAGPEPLPIGPVDPLLRGLIAHTAAYEELAVDAALHGGRDRVVKALLAHPLVGQYALAEGLADRLLAENARFLPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVZ5</accession>
    <name>A0A010ZVZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852826.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4013"/>
    <dbReference type="HOGENOM" id="CLU_021802_7_0_11"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="362" mass="37176" checksum="09F9F2C9BB4B452A" modified="2014-06-11" version="1">MADLRDMLADARALIECESPSSDLAAVGRSADVVAEVGAGILGAAPERIVIDGRTHLRWRLGESEPRVLLLGHHDTVWPIGTLAGRPFAVESGILRGPGCFDMKIGLVMALHAAAGLDGVTLLVTGDEEIGSPSSRALIEEEAKAAAAALVLEASVDGHVKCERKGVSLYEVRVAGRAAHAGLEPERGVNATVELAHQVLAVSALADPATGTTVTPTVARSGVTTNTVPAESTFAVDVRAGSVTEQERVDRAMRSLWTVDPRARIETAGGVNRPPLEASASDGLYATLCRIAVARGLPVPGRAAVGGASDGNFTAGVGTPTLDGLGAVGGGAHADDEHVVIGEITPRTALLRALVEHLLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW07</accession>
    <name>A0A010ZW07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852858.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4028"/>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_11"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="179"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="39585" checksum="C585613EC3478624" modified="2014-06-11" version="1">MSGDLVALRRALHASPEVGLHLPGTQAAILDALDGLGLQIVVGRGLSSVTAVLRGGRPGPVVLLRSDMDALPIVEATGLPFASRNGAMHACGHDLHMAGLVGAARLLAARRASLPGTVVFMFQPGEEGYAGGRLMIDEGVLSAAGERPVAAYAVHVDCVTPGGQLVTRPGPIMSSASALRVRVTGTGGHAAYPHHAVDPVPVAAEIVLAVQSFAARRVPVSDPAVLSVTRLASDSAASNVLAGAVDLEVNIRTLSRETLELVRSGLPALVTGIGEAHGCAVTVEYVDSYPVTVNDPAETERVLALLDERYGDRVVRLPFPGMASEDFAYVLDEVPGSLVFFGVRPPEGSTGGMHSDRATFDDSHLDEHAALLAELAVRRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW79</accession>
    <name>A0A010ZW79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mycofactocin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850806.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_214161_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023988">
        <property type="entry name" value="MftA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03969">
        <property type="entry name" value="mycofactocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="38" mass="4103" checksum="917F638C7AFD24C4" modified="2014-06-11" version="1">MPVETLESTAATETVEVDLVEEDLLVEDVSIDGMCGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWD9</accession>
    <name>A0A010ZWD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570715.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4165"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="41931" checksum="6E881828CAF15CB1" modified="2014-06-11" version="1">MTSVLVSGASIAGPTVAYWLRRYGFDVTIVEKADALRGGGYPIDIRGTALGVVDRMGLLPGLRDAHVDTRRISFLNPDGSLLTSLNPVTLTKSENADLEIRRGDLTTMLYDTIRDDVEILFTDSIAAIDDREVRFESGARRTFDLVIGADGLHSRTRGLILGPEEQYHRYIGYSFAGFGMPNRLGLSHEGVMWNVPGRAAALFAVGDTPASVHAFLNFSLPEPPLDAHRDPAAQRRLIESVFTDQEWEIPAMLDAMRASDDLFFDVVSQIHLPRWSQGRVALVGDAAYAPSFLTGQGSSLALVGAYVLAGELAAHTDHTAAFTAYEKSMRDFVEVNQAQVTAGEATMFPSTAATLERRNTMLRQLSEIPADANPAHSAMTLPDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXG4</accession>
    <name>A0A010ZXG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851396.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376176_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459265" evidence="1">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="20213" checksum="5A911973B9BC92C0" modified="2014-06-11" version="1">MHRRFRSGLLATGVVALLGVAGCGDETPGADRPTAVAGTTAAARVTASASAPAPTGAGDRFSALPPCNEFPASLAGTFQGSVLQVVPRKKAGDTWTEGTACVAMVAAAQQPLSVETYLFRSGAEGEGSARAEAYATSEAPTGEIVTGWGDEARWSAGSCQLAVRYGNVVALFEQLSPTPACRSTIEPIARGFTALHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXP3</accession>
    <name>A0A010ZXP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3080"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="771" mass="83672" checksum="3D8002678EBCCCBD" modified="2014-06-11" version="1">MTPRASQTMRHLIRSGLVAVVAVWVAALAIATNIATELLPQWPWLENRVVMWALVALLTAGTATLGVLQHRQSAEVTSGDRPTNPMAGGPDETPNAPVAHAHNYLAPVTQLYQHSFGARITESVPASNLPPRNPHFTGREDAIARLNRLVSGKRGAAIALHGMGGAGKSQIALEFAHRARTDDHYQITWWVRAESELTMVEDLTRLASALGISAGSDLYTTANDVVIALRSMSDWLIVLDNASDATTVRNWVPGGSGDTLITSRTRPWIGLANGLNVGPFDRLESVAYLINSSSEFAAGNDQTSAEMLAEELGDLPLALTEAATYMEAHRLSLSGYLHLFRRTEAQGSRLTELAVDYPRTVATTWLIHHATLAEQQPGALTLLRLFAFLDPDEIPTWLITDQALALKGPIGRELAWNISESELEELVGSLARLNLVTRLDDSHVGMHRLVAEATRSQLTSDGMNALDWVHWVARIVAASMPDDTWGHESWPVMTELAPHAAKVLEHCGTLPTPEAGELLTKLGAYLAGRGDTTAARNCLRKALTFVRSLEGPYSMRVADVASLLGNAEDDLGNMEAALNYLELSLLITEELFGTDNLTTAFRAGHLGRTLYRVGDFETSQAVLELSLGITAKQAGEMHPMNAFLLSILGRALSKGGSPVNARSALDRARIILEEAFGPDAPQLTSVLAGLSRLQRDAGDLRAARNGIARAISITENTYGPDHPNLESYLRQLSEIETDMGELHRAAVIAQRADALHDAFRSARWAERLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXR5</accession>
    <name>A0A010ZXR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3104"/>
    <dbReference type="HOGENOM" id="CLU_067324_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26191" checksum="E53F5C40A16DEDE9" modified="2014-06-11" version="1">MPAHSWPSSPLAAADRAFALLVHPPTPLEFDGREVTDLPQGPVPLDQLRRLLLKPGTTLLTRDSVWRELVLRARRDGPTWVVVAVGIAMPGLRRAAGTTAAGWRGDTSDLDAELLTGFVARLKTINLDAPRICGRLIDAGVRAARKARDAESNARAISTDTAGPIAPSDHPDLVLARSVAAGVLDADEANLIAATRLERLTLAEAGARIGIGAGLASAWRRRAERRLVTAISDGELSLVPLRPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYL2</accession>
    <name>A0A010ZYL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3391"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109133" checksum="83536F3179F57FB1" modified="2014-06-11" version="1">MTASTRLRLHVLGPLRIVRDGHETDAGPRQQAYVLALMLTRANRPIGMGELVDLVWGDDAPATAPNVIQKHVSAVRRLLEPELRPREAGTYVQRQGTGYRFVAGPGVLDLADFRRLVSEAESAQADGRPEAAFETYLDALALWHGAAGGDFSHGPAARAIFTALDAEFVDACVAAAELGMSLVRPAEVLAPLRLAVSMAPLHEPARAALASTVAAARSTRPPPVPDRRIRSAHAVGLVGRTGELATLREVLDSAASAEGRVVVVDGEPGAGKTRLLEEAGTAAERSGALVVWGHCLDGDGTPSMWPWVEAVGALLDGLPAAPRAQWLAGELGRLVEPRGESLGSLLLPDGGGQLRLFDAVVALLASISAQRPAMLIVDDLQWADTASLTLFGHLAAHAPRGAVLVGAVRTHAPRPGAELVRVLTAAGRTPGHRHLRLAPFDSAEVIELVRREIGQTPAPGVARDIHARTAGNPFFVRELARLLAAGDSLSTDAPARTEVPSTVRAVVLDRMAGLDDDGRDLLRIAALLGRDIDLELLADAAGLDTETSRRRLGPAESLGLVGLSPEAPLSYRFSHDLVREAVSGTVTPMRAHSLHLRIADALTLAGTSDDERLAHHLWSAAPLADPARITDALLRAGSRAAAKSAFDAAEQHFWSAARTARTADRPERELAALGQLITVAGMRSMYGAPALDRLARAEELAARLGREREAADFLFTRWVVHVQGMDFDRSERLARRLLVAGETSGDPVVQAYGLHAWGLQQWSTGNVGEGYRHLARLGRSLPADLVPRAENPLRYDLRLLSAAMLGEVTALHGDVDAARALLDELEVAAGEDRYAITVWATISARTASIVGDHGWALRAAERGIAVDPEFSFAFLGTYQRLVRAWALAMRGNDPEAAAAEVRALLSDRLLDPPVSCVATWYALLAEMRLAAGAPDEAADALDRADQALETFGQRYAEGLVLLQRARLLQARGESAATVRKAARRARALSVEREAHLFAQRVDQLLTELDRPLRPSSSEDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYM1</accession>
    <name>A0A010ZYM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2664937_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="75" mass="8241" checksum="C106E971F32999C7" modified="2014-06-11" version="1">MTTFMRRSQLALGALWLVVGFGWLVLAVVWFGRGGMGDPGFYTGLPVGPVMFLAAWWNFRRAHRGSGPIGRDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYM6</accession>
    <name>A0A010ZYM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3419"/>
    <dbReference type="HOGENOM" id="CLU_062618_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27493" checksum="95225AF3BFE5BEEF" modified="2014-06-11" version="1">MEQSEASGVRSVQRAMDILSLLTEDRPVVTIRDIVEGTGLAKTTVIRLVQTLERTGLLWATTGGYLAGPALWRWAHLARSSWEMPPELTRAMRDLSARHRETVNLYGARDLTRICLAQQESPQPLRHVVRIGDELPLWGGASAKVLLRDADEKRLRRIVRTAPDGAEHLPTLQAWIAEAADRGYAVSHGEREAGLSAVAVPIEGRSGGIVAALTLSGPTVRFGESEVASFARDLVDVGRQLSERGFDHPLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYS6</accession>
    <name>A0A010ZYS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="43258" checksum="4BFCBBE82C51F457" modified="2014-06-11" version="1">MAAKHRAIADPERVADRLRRFAVTHPTATRLIGVGVLLLLTVIVTAVPDPSAFTPTAIVTAVVVAASFVVIPALHWPDWFIPAIATAGVIAATPSGATDSPARSALILAIFLFSWRSENVLAVVVTTAASVAAVLAGGAVATVYDHIGWDAFEVLPWVVAAAALGQAFRAHQARRAMLVERARRAELGREIEARNRVQAERLRIARELHDAVGHQVALINVQAGAMTLLLDRYDLDRARQSLEHIQDASEAALSELKLTVGLLRQPGEHEPVEPAGRLSRLDELIASFTATGLRVACNVIGPARPLPDAVDLTAYRLIQESLTNTAKHAAGTSASVRLDFRPGVLTLTVEDDGPAARTGPRVAAEGTIGHGIIGMRERAAALGGRLSAGPRPEGGFRVTAELPTLVGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYW4</accession>
    <name>A0A010ZYW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852177.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="23146" checksum="C30282B1E8F27069" modified="2014-06-11" version="1">MVSTESVPRSKRRATSQKSLGRRSELLAIAAEMFATRGYAQTTVRDIGDAAGILSGSLYHHFDSKEAMLDEILRDFMGSLHSAFAAIAAEEEGPRQVLEGLIRYSIATIHDRPHAVALYQNESSLLAHLPDFSYVAQISADIAKIWLDVLAAGREAGTFRRDLEPGIAYRFIRDSVWGSVRWYSPDGALDHETVAEQYQKMLFGGLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYZ1</accession>
    <name>A0A010ZYZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein, SWIM type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852232.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3576"/>
    <dbReference type="HOGENOM" id="CLU_023622_1_0_11"/>
    <dbReference type="OrthoDB" id="448815at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="45052" checksum="3E77EE1D2F8E6724" modified="2014-06-11" version="1">MTAGIQEVVYRRPSALAGDGLVLETAGRHASYFTGFLTAARPAAMGLATLADVAAADFRRDQIGTRGLRDPVVTCAQERLRFETLSGCCGLYARLDVLPAALDGEIRARGTTNVDVNPPLYTALTQVGGGDRLRLTIGPDELAVTTRNAHVVEKRVPLPERWLRGLAEAGFLAAGFDLRAEIPGGHAAALLHRLPAHRGDDRWFVPAGRSVRATSVAAPGAVCLAGAHRLSLVRPLLPFTRTLRLYGPPVAAGSAPTASGWEFDLGAVRFSVLLSPGINRGLSGEGGLLPHLAAADPLADELGGDGTVDPAASANSEGLSGAQVRGALAALATSGTVGYDWSEAGWFHRELPYRPDLLAVAHPRHAAARALVAAGEIEPVAGGYRVGTRLVHRGADGTWGCTCPWWSERYGRRGPCKHVLAVSLLAAGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ91</accession>
    <name>A0A010ZZ91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852408.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3694"/>
    <dbReference type="HOGENOM" id="CLU_062618_4_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="80"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="28137" checksum="0302CC889C9A3497" modified="2014-06-11" version="1">MTEDQDDKPETAREQDIQAVSRTAQILGLFGPETPELSVAEATRRLGLKRTTVHRYFSSMISSGLLERVEESALVRPGRSILQLGSFMLGQQRIMQMAPAYLRELALEIKVSTVLSLWGASGPVVSLVEEADHPTLVTVRVGSQLALNSSQAKVFLAFLPDQFHADRLTGSLPEPQRTDVRSRIATIRQAGMSSDVNHRGICILAAPVFAASGICATIAAVGTERMLPAALDSREATALKAACKRLTKEMGGTWPEPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A047</accession>
    <name>A0A011A047_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4021"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="124"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="35706" checksum="FB20C5ED6FBFFB8A" modified="2014-06-11" version="1">MTLPPSPSVTTVEEKDTRGEVLRSFVSSPRLTFVLRRLGRAAISLLIVLVASFFMVQFVPGDPVRAALGPTAPVATVDALRDQLGLDQPLWSQFTHYVSGLLHGDLGTSITSQRSVAETLGERLPTTLTLAFLAFVVAAAGAFPIGVATAVSARAGRRRVVDLGVSGLLGVLIAIPNFLLAVLLVAVFSIGLRAFPPAGWGEPSQAVLPVLALAVGPLAYLARIVHVEMLRVLDAPYLTTARSKRLPGRLLYLRHALPNIVAATLTAGGVVLVGLVAGTVLVETVFTVPGIGSTIVSSITAKDYPLIQGLVLVYALLVLGVNLLIDLALAVLDPRSTIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAQ4</accession>
    <name>A0A011AAQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860177_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="7199" checksum="8623C67BE7C037F8" modified="2014-06-11" version="1">MPISVVLRGGPVRERVVDLPVDEAPELLPIQTTSGETPYRRTGARDKQGRRVYEPARLIDRLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB96</accession>
    <name>A0A011AB96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569580.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899931_0_0_11"/>
    <dbReference type="OrthoDB" id="1120188at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="26441" checksum="55652D054E183588" modified="2014-06-11" version="1">MTDELSAALAALRDADLVVPVPPVEPLTWATVSVSGQTWLPAFSSAALVSEPSRPIAFRQLAAFWPDPGWGLAVDPGLPSQLLLEAGTVARLAREPIGGGLLQMVVTFDQVTAYLGGEALDISGFAHAVDDASLPGSPGPLLEALGLPASDDVYLLRWFSVGPALYRIPYGWTDEAGAAAMSGWVVEPPPFRGTGFVAGPALVIREYKVDGLMPPHGSEIFHLPVDGPERRIAVFDADHRRWLMVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABG7</accession>
    <name>A0A011ABG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847942.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="22897" checksum="CD89B0CA7364B424" modified="2014-06-11" version="1">MRRRLTSASRREQLLSVALDEFGRRGFHLTQMEHVAAAAGVSKGLLYQHFESKEELFSAVTSSIVEGLSVQLHEATKPGDPGLERMRVLVRTLFDFATDQPSAWAVMIRHFDKPEVGDELQGVRDDLGAIIVDLMLLNRRNNPTRLAAAEPVVTLFAPIVTGGLMSLISWWLDHPEVARERAETMAVEFLWLGLERIRAGERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABL8</accession>
    <name>A0A011ABL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat</name>
        <name evidence="5" type="ORF">CryarDRAFT_0451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848042.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.435"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_11"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="38489" checksum="870DE6D2734BD3BC" modified="2014-06-11" version="1">MPLTRADLDTIPRYVAGRNPSDVAREVGIPEAVKLASNEVPFGPLPGVVEAVAEAMAQTHRYPDPGVVALRNRLGERYGVAPDRLVSGCGSVALAEHIVRAAVLPGDEVLYSWRSFEAYPIITTSCGGTSVRVANTHDHAHDLDAMAAAVTDRTRVAIVCTPNNPTGPAVPREDLERFLDQVGPDVLVVIDEAYREFVRDPAVPDGLDVARNRPNVVVLRTMSKAWGLAGIRVGWLAADPQVAEAVRKVVTPFSVNHVAQAAALAALDAEDEMRRRVDIVVAERTRVHAAIKQLRPDVPDTQANFVWLPLGDDAADFARSCEKRGVIVRPFAGDGVRVTIGTPAENDMFLSAASELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABV5</accession>
    <name>A0A011ABV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848225.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2914760_0_0_11"/>
    <dbReference type="OrthoDB" id="1963656at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="61" mass="6460" checksum="20D82811EE8D0FE2" modified="2014-06-11" version="1">MASEAKHTSKNTSVKDGHLAVSEFLGEHQGPSSPFGDIPLPLPADRIDYVHPDSGDGATHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACT5</accession>
    <name>A0A011ACT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">CryarDRAFT_0904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.890"/>
    <dbReference type="HOGENOM" id="CLU_134276_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="16887" checksum="96205F64F455BB3D" modified="2014-06-11" version="1">MALGGIRRRAEFFVPRRRWYRWLIADARGLVQMGERTLRGSRLGAVSYETDRNTELAPRQQGEYLCPRGHRFTVPFAADAEIPITWECRADGTVARIIDGDEPEAKKAKPPRTHWDMLLERRTVAELEEVLAERLEVLRGRRSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD63</accession>
    <name>A0A011AD63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1032"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_18_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="307"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="580" mass="63297" checksum="0DDDFD61771F9E70" modified="2014-06-11" version="1">MRRRARPDAPDGRVRLVYQRFRRAAGWLSARGLARWRRSLQLRVVTSTLLASSVMTVALGLFVVHRVTDGLVVAEKEQALEQLASGVTYLGDELSSIKGQDDPELDSVLRQAARNLSDRGSRATDFAVAVLPTGNRRLSPKYVPRYSPDDVRPPAQLTRLIATGEQRGYQFTRTSLDDRPARAFLVVGAPVDTQAGRFDLYYFVPLDDQVATVGLVQNSLTAIGALLLLLLAAIAGIVARQVVTPVRVAARTAERLSAGLLEERMVVRGEDELARLAHSFNQMAANLQRQIVQLENLSRLQQRFTSDVSHELRTPLTTVRMAADVIHAASDTFPPALARSTELLSNEVDRFESLLNDLLEISRYDAGAAVLEPEDTDVRTIVTRTADGLAQLAERTGSELKVVLPDEPVVAEVDPRRVERILRNLVGNAIEHGEGRPVRITLASDADALAITVRDYGVGLRPGEAQAVFDRFWRADPSRARQTGGTGLGLSISREDARLHDGWLQVWGWPALGAQFRLTLPLRRGERLSAAPLPLAPADAGSRYPRAIEASPRALPPVPTHPALTPGPADAAGTEGEQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADB7</accession>
    <name>A0A011ADB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">CryarDRAFT_1111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1092"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="25988" checksum="B51947321C77CFFC" modified="2014-06-11" version="1">MWLNSATVITLDRVTKTYPKSRRPALDDVNVNVEKGEFVFFIGPSGSGKSTFIRLLLKEDTPTTGKVLVAGKDVASIRPWKVPQLRRSVGCVFQDFRLLPNKTAAENVAFALEVIGKTRSVIRRVVPEVLSLVGLEGKENRYPHELSGGEQQRVAVARAFVNRPLVLLADEPTGNLDPDTSIEIMRLLDRINRTGTTVVMATHDSNIVNQMRRRVVELDRGRIIRDQARGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE52</accession>
    <name>A0A011AE52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849132.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1349"/>
    <dbReference type="HOGENOM" id="CLU_086313_0_0_11"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27783" checksum="78C5F208E6BB555C" modified="2014-06-11" version="1">MAPMLEGFDRFDFTHHGVTHPVYRAGNGPAVIVIAEIPGITPRVIEFAQRVAALGLTVYLPSLFGIPGRAPDGKAMATALRHVCVSREFTRLALRKASPVTVWLRALAKQAHEESGGPGVGAVGMCFTGGFALAMAVDRRMLAPVLAQPSLPFPLGAARKSDVGLDTASLARVKERCADEGLCVLGLRFTGDGISPPERFDRLRRELGDGFVGVEIPSSTVPAGPKAHSVLTEDLVDEPGHPTHEALEQVLQLFRDRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFA0</accession>
    <name>A0A011AFA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEP phosphonomutase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849725.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1757"/>
    <dbReference type="HOGENOM" id="CLU_027389_2_1_11"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="28275" checksum="98CE3E3D704EFF21" modified="2014-06-11" version="1">MTEQTPTTQAAKARHFLELHRAERPLLFPNPWDVGSAVLFTSLGFKALATTSSGHAATLGRLDGEVTRDEALAHAAALSAATELPVAADFENGFADAPDAVADAVTAALVTGLAGLSVEDATGRDDAPIYDLGLAGERIAAAANAAHAGPVRLVLTARAENYLYGRTDLADTIARLQAYQEAGADVLYAPGLTTAEDIRAVVTSVDRPVNVLARPSGPTVAELAELGVSRVSVGGSFAFAALKAAVDAATEFRDQGTFGFLAAARDGSAAAKKAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFV8</accession>
    <name>A0A011AFV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850039.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1971"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_11"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="35405" checksum="388E99307AB9DB59" modified="2014-06-11" version="1">MTIRVGINGFGRIGRNFFRAALTSGADIQVVGVNDLTDNATLAHLLKYDSILGRLPHEVKASADEISVGGQTIKALEERDPAKLPWGDLGADVVIESTGFFTDAAKAKAHLDGGAKKVIISAPAKNEDVTVVMGVNHTDYDPASHHIISNASCTTNCLGPLAKVLNDEFGIVKGLMTTVHAYTQDQNLQDGPHKDLRRARAAALNVVPTSTGAAKAIGLVLPELKGKLDGYALRVPIPTGSATDLTVELGRDATVEEINAAYQAAANGPLKGYLSYNSDPIVSSDIVTDPASCIYDAPLTKVIGNQAKVVGWYDNEWGYSNRLVDLVNYVGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG19</accession>
    <name>A0A011AG19_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725693.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2031"/>
    <dbReference type="HOGENOM" id="CLU_1040986_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="25481" checksum="A0A250DCF2D089F5" modified="2014-06-11" version="1">MTAPLSESSNVGATLNQALGAAPVKPPSADLDKDAFLKLLVAQLKYQDPMNPAQGTEFVAQTAQFTTVEKLTDLAEVQQQMLTAQLTLGAANLVGKDVTYTDATGNSVTGKVEGATLGSNPSVTVNGLSIPMSSVTAVGKVGLATSTSPVAGGSGDMVTPIGDAVPGATTPQSPLPTTVPGTTAPGGPTSPGTTAPGTTAPGGTAAPGTTAPGTTTPGTTTPGTAAPGGTAPGGVSTGSPDPATASPTTPPGPTTPGTAPDATDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGL0</accession>
    <name>A0A011AGL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850346.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2216"/>
    <dbReference type="HOGENOM" id="CLU_025133_0_0_11"/>
    <dbReference type="OrthoDB" id="332708at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="660" mass="73045" checksum="29F08458191D4E59" modified="2014-06-11" version="1">MATLGAELEELRRQSFVGRDAEIAVFRAALDAPGVIFVHGQGGVGKSTLLDAFARLAAEHGHHPIRVDARHLALGAASLPAPSGEERPVLLIDTYELLSPVDDWVRETYLPALPSNCLVVIAGREGPGPRWRADPAWRALLRVVTLGNLPGEDGRVWLAAQGLPAETQDRLLTISRGHPLTLSLLIDAVRRGADPRALGDVPDVVGALIERIVGEAPSPRHRMALEVCAHAPVTTEDLLRMMIGGDVSELFAWLRSRTFVEESAHGLHPHDVVREVLDADLRWRDPDRYADLHRRKLAAFQRQVGALTGERERVQLLVRTVVLNGVRSGLEALSTLAPPMQVSADTLTPDDRAPIVAMTAEWHGAEQAGLAAYWMERRPADFRVFRTATGELCGYTACLDVTEADLGADPGVDAMWLYASKSGAPRAGERVRIWRFFLDREQGQRPSPALTLFVAYQMLDIIQLPDDMAWTFVAALENAELWTPTMDFLDFWSAPEADFTVGGSRYPVYAHDWRRAGVTEWTEVLHARQLGAPARPAARSIDEPVLTRSEFTDAVRSAVRGLHAPDQLRRNPLLRSRMIRRNTRAGRTPVDTLVEMIEAGIGALPDDASELMTRTFLRPTVAQDRLASELHLSFNTYRRHRDRAIASLASSLWQHETGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH23</accession>
    <name>A0A011AH23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570053.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2369"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="41672" checksum="6A14BA919196D22D" modified="2014-06-11" version="1">MRVGIVCPYSFDVPGGVQAHVRDLAEALLGLGHEVSVLAPAEEPADGGQALPPYVVAAGRAVPVPYNGSVARLAFGPLSLARVRRWLRDGRFDVLHVHEPIAPSLSLLACVAATGPIVATFHTATQRSRTLAAVHSALQPVLEKITARIAVSALARRVQVEHLDGGAVEIPNGVAVARFADAPPLPGWPGEGGALGFLGRFGEPRKGFTVLADAFARLAPDRPGLRLLVAGPGDADDALDALPRALRPRVTLLGTVSETDKARMLSSVDVYVAPNTGGESFGIILTEAMAAGATIAASDLDAFRRVLDDGRAGALFPTGQPAALAHCLGELLDDPARRRALAAVGQSTVAAFDWPVVAARVVDVYQSAIAAYPSEPTVTDADEVSTLRLPHYLRERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH86</accession>
    <name>A0A011AH86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">CryarDRAFT_2482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850672.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2445"/>
    <dbReference type="HOGENOM" id="CLU_025086_0_0_11"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="133"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG81371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="39338" checksum="6A9667D5F870FACA" modified="2014-06-11" version="1">MSGPNDPYDPKQVALLSAEALGDATLNAEKAFADAADLDGLHAAKSAHLGDRAPVSLARRELGALPPQARADAGRRVNETRKAIQAAYDAREAILIVERDERVLRDEAVDVTLPFDRRPRGARHPIAALIDRVSDLFIGMGYEIAEGPEIEAEWLNFDALNIAPDHPARTMMDTFFVEPPEGGLVLRTHTSPVQARTMLDRREPPIYIAAPGRVFRTDELDATHTPVFSQVEGLVIDKGITMAHLRGTLDHFSKAMFGPEAVTRWRPSYFPFTEPSAEFDVWFPQAKGGPRWIEWGGCGMVNPRVLIACGIDPDVYTGFAFGMGLERALQFRHEATDMRDMVEGDVRFSTAFGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI88</accession>
    <name>A0A011AI88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851138.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2787"/>
    <dbReference type="HOGENOM" id="CLU_000445_87_2_11"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="27248" checksum="B4250D04E8E37E79" modified="2014-06-11" version="1">MSRYGHGGAVVVGDVELAGGQWFPPHRHTVHQLVWSRKGVGSVRIDESTWFLPRTLALWIPAGVEHATGAIDPSWNRSPYFLPERCPIGWPEPTVVAVTPLLAALIDHLADFGLGPGERVRAEAVVFDLLRPLEAVTIPLPMPSDVRAARVAAALLANPADGRTLAEWGREAGASARTLRRVFLAETGLSFGRWRTHARLRAAMPVLATGHPVAAAARRAGYGSASAFVAAFHRTVGVPPGTYFGGGTDNPARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AII3</accession>
    <name>A0A011AII3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2893"/>
    <dbReference type="HOGENOM" id="CLU_095342_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="46"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26713" checksum="B17AF5085CF7EEAA" modified="2014-06-11" version="1">MSSLRANPAVSSIHQSLDFYWGNDVRDAAMDAFHATFVRPGDLVFDVGAHVGDRVASYRRLGARVVALEPQPLCGRALTEIFADDPAVRVVEAAVGAEPGSVTFYVNTANPTVSTVSKDFVEAAFGANGWHGQVWDTEISVPTVTLDELIGEYGEPAFVKIDVEGYEYAVLSGLSAAVPALSFEFTTIERGVAQQCLDRTVALGFTSFNVALGDAMDFEFAAWTSAEDVAAHLAGLPHEANSGDVYCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIM5</accession>
    <name>A0A011AIM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851323.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173379_0_0_11"/>
    <dbReference type="OrthoDB" id="2017453at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="88" mass="9462" checksum="98917A829734904A" modified="2014-06-11" version="1">MVRLPLTPEEVERGQRLGALLRTARGERSMLHTALDAGVSPETLRKIESGRVATPAFPTIAAIADVLGLSLDAVWSEINRAGREQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ41</accession>
    <name>A0A011AJ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851569.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3128"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_11"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="79"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33268" checksum="6E317C57F8A09746" modified="2014-06-11" version="1">MNRPGLDPELGALLADVPLSSVLDAELLAQFRAYPSPPVETYLRGRAAGLRDVTVTAADGAAIPVSIFSPPESEAAPCVLWLHGGGMVMGDRYSQIDIPLEWLDRFGAVVATVGYRLAPEATGMTPVEDCYRALTWTVEHAAELGIDPARIIVAGISAGGGLAAGLTLLARDRGTPSIAAQVLICPMLDHRNGTTSSHQFSGDPGVWTREMNEFGWRSVLGDLAPDDVPGYVSPAVAEDLSGLPTTYVDAGTAEVFRDEDVAYATRIWAAGGQAELHVWAGGFHGFDALYPHARIAAAARRTRNNWLQRVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJA3</accession>
    <name>A0A011AJA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851678.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3197"/>
    <dbReference type="HOGENOM" id="CLU_014312_8_1_11"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="4">
        <location>
            <begin position="447"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="576" mass="62211" checksum="B27EDE061C79566E" modified="2014-06-11" version="1">MSPSERRLATSVLVIGSGGAGLRAAIQLAERGTDVLLVGKRPVADAHTTLAAGGINAALGTMDPADTWQQHAADTLKESYFLADPHTVRIVAENAARGIADLERWGMPLAREADGRISQRFFGAHTYRRTAFAGDYTGLEIQRTLVNRVRQLGVPIIDTLYVTRLLTRDGVVFGAYGFDIDDGARYLVHADAVILAAGGHTRIWRRTSSRRDENTGDAFRLALTAGARIRDPELVQFHPSGLIEPESAAGTLVSEAARGEGGILRNALGERFMERYDPARMELSTRDRIALAAYTEIKEGRGTPHGGVWLDVSHLPRETIMQRLPRVYQTLIELQMLDITTTPIEIAPTAHYSMGGVWVRPEDHGTGVAGLYAIGEAASGLHGANRLGGNSLTELLVYGRIVGDAAADYSADIEAQPRSAAAVALARDEVSELLAADGPENVRALQRAIRDTMTEHAGVVRDDNGLRAGLVQLDDIESATKSIGVHPDLAGFQDLAHAFDLRSSLLSARATIEAAIERRETRGCHNRSDFPEPDESLRVNMVWSGPGEIDQEPIAETPVEIAALIREVSTTGKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJC7</accession>
    <name>A0A011AJC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3220"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="854"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="923" mass="98618" checksum="5D915B75FDDB79F7" modified="2014-06-11" version="1">MAPSTGSELRGRVAELEVVRKLLDDARAGNSAALVVHGDPGIGKTALAEAALGRFTTRMRVERTVGVESEMELPYAGLHQLTAGMLDRAAGLPAPQRDALERALGLRTGDAPSPFLIGVAVLGLLTEVAVEGPICCLIDDTQWLDDASRQALAFSARRLGSEGVVLVFVMRTVDATFRGLPELAVPSLNDDDARGLLAQVLPGRIDARVRDRLVSEARGNPLALHELPSALSPTEIAGGYTVAGNTTLTTRIEKSLLDQLGSLPEAARRVLLVAAADPTGDPQLLRAAVRGLSLSPDAIDEAERSGALTLGTRVGFRHPLIRSAIYRTASPPDRRRAHAALAEATPVELDPDRRAWHRGQAAVEPDEEIAGVLEESAVRARGRGGVAAAAAFLERAAALTPRPADRARRLLAASRAKLEAGAPEAAERLLSVLPADALDPIGTAQVALLRAQADFARRRSPRVVREILAAASWPDVHDADFVRKAHYEALFIAQYTLGGTRSDPGTGDVPFSDLCRAVFDATDADSTHPMDLLLRGRALIGLGKRAEAIPVLRRAVAGLIDASAPLIPSRSAGLDSNAAIETWDVDALWTLSDRHVGLARADGQLTVLPLVLSYAGAARLAQGRLAEAELIADEIDVIKDAIGHPFRRTHRLLTAAWRGDTGTVSRLASELRQNVAAGDLVTPTIANFAEAILANGVGNPEDVLRVGRGELDQIHLLTYSSRILAELVEAAVRVGDRAIADRALAELTALTEPVGGDWALGMLAAGRALTSDPADAEAHHREAVERYRRGGLAVYEGRARLAYGEWLRRRRRRIDARGELRTAYELLSGRGAAAFAARARRELEATGETALSRLVDPGDALTVQEANVARLVADGLSNREIAARLFLSVRTVEYHLRKVFLKRGVRSRRDLADALRAEGTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJE3</accession>
    <name>A0A011AJE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570342.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3235"/>
    <dbReference type="HOGENOM" id="CLU_000022_35_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1387"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2833"/>
            <end position="2908"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1422"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="3474" mass="357984" checksum="02AAF15E49A35B1F" modified="2014-06-11" version="1">MGENGRKVVDALRAAVKETERLRRQNRKLVDAATEPIAIVGMGCKYPGDVASPGDLWELVRSGTDAISGFPIDRGWDLAALSTGEVDERGTSISQQGGFLRSVADFDPGFFGISPREALTMDPQQRLLLETTWEAIERAGLDAVRLRGSRTGVFVGTNGQDYAYLLIRSLDDATGDIGTGIAASATSGRLSYSLGLEGPTVTVDTACSSSLVALHLAVQALRNDECSLALAGGVNVMSIPGALVEFSRQNGLASDGRCKAYSDAADGTGWAEGVGMLVLERLSDAQRLGHDVLAVVRGSAVNSDGASNGLTAPNGPAQQRVIRTALASAGLDVSDVDVVEGHGTGTVLGDPIEANALLATYGQGHPADRPVWLGSIKSNFGHTQAAAGVAGVIKMVEALRHAEIPPTLHVGEPSSHVAWESGAVRPVTARMPWPERDRPRRAAVSSFGISGTNAHVILEQAPAVEPVSASDALVPWVVSAKSADALDAQVARLRDVSGSSFVDVGHTLTQRSVFEHRAVLLADPGSSEAVSVAAGVARGGTDVGVVFSGQGSQRLGMGRELYERFPVFADALDEVLAGFSGAVREVMWGDDSGALARTGFAQPALFAVEVALWRLIESFGVRASVVAGHSIGEIAAAHVAGVLSLADACVLVSARASLMEALPEGGVMVSVRASADVVTPLLTEGVSIAAVNTPGSVVLSGEESAVDAVVSALGAKSSRLSVSHAFHSALMDPMLEPLTEVATGLSLSKPTIRLLSGVTGAAVEQLEPSYWAAQVREPVRFADVVAGMDVGVILEVGPDGVLTALIDRAAVATLRKDRPEVAALLTGLAGLFVRGVPVDWAPAFAGLGARRVDLPTYPFQHERFWPNRLAAAGDGGGDGWWSWVESEDPAVLAARLGVDEEAVATVLPALASWRRGERERSEMDGWRLREVWKPISVGTSAPPGTWLVVVPSEVLDEAWVGAVSGAVSAVRWDVAEPDRDAWAARLREWGTDFSGVVSLLRDVVASATLVQALGDAGVTAPVWALTCGAVSAAPGDVIEDVDQAAIWGFGRVVALERPAGWGGLVDLPPDIDAQVARRLAGVLTGDEDQVAIRSRGVFGRRLVQSGPGQSSWDPSGTVLITGGTGALGGQVAVWLAGRGAERIVLVSRSGDAAEGVAELVGRIEASGARAEVVACDVADRDAVAAVLDGIPDLTAVVHAAGVLDDGTVEGLSAERFASVLRAKASSAIVLDELTRDRDLDAFVLFSSTAGAVGNPGQANYAAANAVLDAVAYRRQAVGLPATSIAWGAWAGAGMAARLGMAGMDPALALTVLGQVATAGAPYVVVGDLRRPGILRALLTLRPAPLLSDLPDAAEILADVRAGQARQEEAASGLRATLAGLDPAARAALLGETVREHAAAVLGHTGADRVDPERAFRDAGFDSLTAVELATRLSVVTGLRLSSTLVFDHPTPQALAAHLLGELGSGPGEVQPSVPVAVVDEPIVIVGMACRFPGGVRNPQDLWRLLVDGEDAIGPFPTDRGWDLGLLAGGERGGSATGVGGFLDGAGDFDAGFFGISPREALAMDPQQRVLLEASWEALEDAGIEPGGLRGSRTGVFMGTNGQDYTSLVLNAAEDLEGHAVTGLAASVISGRVSYMFGLEGPSVTVDTACSSSLVALHWAAQALRSGECDLALAGGVTVLSTAMNFAGFSRQGGLATDGRCKAYASAADGTGWSEGVGVIAVERLSDAQRLGHRILAVVRGSAVNSDGASNGLTAPNGPSQQRVIRAALGSAGLAPGDVDVVEGHGTGTVLGDPIEAQALLATYGQGRDTPLWLGSIKSNLGHTQAAAGVAGLIKMVLALRHGVLPRTLHVDSPSSRVDWESGAVRVLTEATDWPDLERPRRAAVSSFGISGTNAHVILEQAAAGEPASAPDGLVPWVVSAKSVDALDAQVERLRAHRGARSVDVGYTLMQRSVFEHRAVVLAGEDLVRVASGVARAEAAVGVVFSGQGSQRLGMGRELYERFPVFADALDEVLAGFSGAVREVMWGDDPGALARTGFAQPALFAVEVALWRLIESFGVRASVVAGHSIGEIAAAHVAGVLSLADACVLVSARASLMEALPEGGVMVSVRASADVVTPLLTEGVSIAAVNTPGSVVVSGERDAVDRLVEALGAKSTRLPVSHAFHSALMDPMLAPLTAAAAGLSLHEPTIRLMSGVTGEAVERLEPSYWAAQVREPVRFADVVAGMDVGVILEVGPDGVLTALIDRAAVATLRKDRPEVAALLTGLAGLFVRGVPVDWTPAFAGLGAGHVDVPTYPFQHERFWPTPRPAATVDGADDLRWASEDPAALAARLGVGVEAVTEVVPALVSWRRGEREQSEMDGWRLHEAWRPISVGNSATPTGTWLVVVPAGHADEAWVDAVSGAVSAVRWDVAEPDRDAWAVRLREWGTDFSGVVSLLRDVVASATLVQALGDAGVSAPVWALTCGAVHAVPDDVVVDVDQAAIWGFGRVVALERPAGWGGLIDLPPTLDARAVRRLSAVLVGDEDQVAIRSRGVFGRRLVQSGPDLAAPWQPSGTVLITGGTGALGGQVAVWLAGRGAERIVLMSRSGDAAEGAADLAARVTAAGAQVHVVACDVADRDAVAAVLDGIPDLTAVVHAAGVLDDGTVEGLSAERFASVLRAKASSAIVLDELTRDRDLDAFVLFSSTAGAVGNPGQANYAAANAVLDAVAQRRHARGLPATSIAWGAWDGAGMAADTPARDGLRRVGATGLDPRLALTVLGQVATAGEPYVVVGELRRRPILTALLTLRPAPLLSELPGAADVLAEVRAARELQAEAASGLRGQLSELDADGRTGLLRDVVREQAAAVLGYPGPDRVDPERAFRDAGFDSLTAVELAARLSVVTGLRLSSTLVFDHPTPQALASHLLGELGSGPGESRPSVPAAVVDEPIVIVGMACRFPGGVRDPQDLWRLLVDGDDGIGPFPTDRGWDLGLLAGDGRGASATGVGGFLDGAGDFDAGFFGISPREALAMDPQQRLLLEASWEALEDAAIEPGGLRGSRTGVFMGTNGQDYSSVVLNANQDLEGHAVTGLAASVLSGRVSYVLGLEGPSVTVDTACSSSLVALHWAAQALRSGECDLALAGGVTVLSTAMNFAGFSRQGGLASDGLCKAYADGADGTGWSEGVGVIAVERASDAERLGHRILAVVRGSAVNSDGASNGLTAPNGPSQQRVIRAALGSAGLAPGDVDVVEGHGTGTVLGDPIEAQALLATYGQDRGTPLWLGSIKSNLGHTQAAAGVAGLIKMVLALRHGVVPRTLHVDTPSSRVDWSSGAVRVATEATTLPPLDRPWRGGVSSFGISGTNAHVILEQSPIPEPAPDALVPWVVSAKSVDALDAQVERLRAHRGARSVDVGYTLMQRSVFEHRAVLLADPGSSEAVSVAAGVARGGTDVGVVFSGQGSQRLGMGRELYERFPVFADAPGRGAGGVLGCGAGGDVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKA2</accession>
    <name>A0A011AKA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3541"/>
    <dbReference type="HOGENOM" id="CLU_004665_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="750" mass="81447" checksum="7CCEDFD639E4581D" modified="2014-06-11" version="1">MPVIDDGGTALWFGVLGPVQVRRQGAEIDLGPRQQRLILALLLANAGQPVGINDIVDVLWDQRPPPSAVNVVHRYVGAIRRSFEPGLAPRSAGRWLLGDAAGYRMRVDAENLDLLHVRRLAEQARSDEEAGRLTEAMSAYETALGRWRGPCAGISELATFDHLAFGVVDHECADLVRAAATLAVRLDRARSVLSVLRRMAEQRPWDEALQAQLLLALSADGKRAEAITLYQNVRGRLADELGVDPGEELREAFQRVLRQDSAEPGPSPVPGRLRIAGVRATHRVLPAQLPADLPHFTGRDEARHRTLSVVNGQVLARVSMPVLAIDGIPGIGKTSLAIHLSHQLADAHPDGQLYVDLRGFDPGRVALPPAEALHLFLNALGVPDAEIPANLDARSGLYRSVLAGRRILILLDNAHDVEQVRPLLPGAPGCLVLVTSRRRLTGLATAHGARLMTLDVLSADEARAFLIARVGAARTADDPRALDEIVERCGRLPLALAVVAARALTHPDLRLTDVARELRETRGSLDGFSGDDVSSDIRTVFSWSYQRLGVRAARTFRLLSLHPGADVTLSAMAGLAGEPPAEMRALAGELVRTGLITEYRPGRFSTHDLIRAYAQELMRSHDDEPDRDRATRRLVQHHQLAADRLLDPTTPREPPPTVVAPARNAADEAVAWLTADREVLTATVHREIDEGRPATTARACPRAASAARDHPGRAHGSRSTLGPVTFAQGNHPDSVARLRVPRRYGPQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKH3</accession>
    <name>A0A011AKH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin-like cation-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852276.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3622"/>
    <dbReference type="HOGENOM" id="CLU_1802898_0_0_11"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="15741" checksum="65392AA626AEE13F" modified="2014-06-11" version="1">MSPADVATARRLYAQHESIRPLVEQVRAVADALTRPDPRVEPVRTLLGQLRRELLPHEHAEEADLVPILNRTLGGADATGAISRTHAEIEQYVVRLGRALDAITTTENLADLQRLLYGLYAILRLHNAQEEEAAFSLVPGPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALS6</accession>
    <name>A0A011ALS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2786892_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458421" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="68" mass="7587" checksum="BC462936D6E594C9" modified="2014-06-11" version="1">MAPERYRLCMAKRRRLKTVLFLTALGVSATAVAVVVARRREEAELRESGVLPLEYGAEPVLDAVTTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFQ3</accession>
    <name>A0A010YFQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847473.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.73"/>
    <dbReference type="HOGENOM" id="CLU_111456_0_0_11"/>
    <dbReference type="OrthoDB" id="1767315at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="20101" checksum="FCEFC9033042FC97" modified="2014-06-11" version="1">MTDNQSPNELPDTPGQTVMVMGPDGSPVGAMPIEVGKEDGDNDPSRLIEQPGKVMRIGSMIKQLLEEVRAAPLDEASRARLKEIHARSITELEDGIAPELREELERLSLPFTDEAVPSEPELRIAQAQLVGWLEGLFHGIQAALVAQQMAARMQLEQMRGRPALPPGLGGIVANDGTPGAHGTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGN8</accession>
    <name>A0A010YGN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848068.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.449"/>
    <dbReference type="HOGENOM" id="CLU_001681_2_0_11"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="801" mass="86718" checksum="E09E9102C443C635" modified="2014-06-11" version="1">MVTRAFGVPMTRREDPRLVSGNGRYLDDLGENALAVAFVRSPHAHARILDVDVTEALEVEGLIAIYTYEDLAEDPNPRVSEPLPLLIPHPALHAPRVNTPLAEGVARHVGEAVVMVVATDRYVAEDACERIVVEYDVLPPVVGIPAAIEASHRVHADVADNVSAHLVQEVGDAPAAIASAPHTLSLDLDIERSASMPMEGKGVYARWDAHDRSLLVYTSTQASTSVRFALAAKLDLPVDRVEVIAPDVGGGFGVKIVHPWPEEVLIPWAAIKLGREVKWVEDRREHFISSTHERGQLQKVTVGFDDEGHVLGLDVEFWHDNGAYTPYGIIVPIVTSTQLLGPYKPGAYRVEFRSMYTNTVTVTPYRGAGRPQGVFAMERTMDAIADALGLDRAIVRERNFIQPEDMPYDHHLTFQDGRPLIYDSGDYPTSMEKIKALVGWDEFEAIREAARAEGRRVGIGLACYVEGTGPGPYEGAFVRVETTGKVVVATGLTTQGQGHETVFAQIAAEELGVPIDDVSVTTGDTRRFKYAVGTFASRAAVMSGNAVALTARKVRAKALRIAGEALEADPKDLEIVDGVVRVRGVPGDGIPLRTVAVLSNPLRYAFDEEAKRATQFAGTSDMSKPPIDEDDEPGLEATDYYSPIRSTFASGMHAAVVETDPETAEIKILRYCVVHDCGTLINPRIVEGQIHGGVAQGVGGALYERIVYDENGQPLNASYMDFLIPYASEVPKVETDHLETPSPLNPLGVKGAGEAGVIPSAALFASAISDAEGFFVNRMPISPSELWALREQHALASEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGP1</accession>
    <name>A0A010YGP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848080.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.454"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21495" checksum="17AE13726A7F57F7" modified="2014-06-11" version="1">MAGLRERKRQRTHDTISATAIGLFLERGFDAVSVADVADAADVSKPTLFRYFPTKEDLVLHRIGDHMGEAARVVRGSADPIGALHRHFVDGLTRRDPVTGLNDVPEVLAYHRLVFETPALAARRAAFTDEDERALAAALVAAPGNAGELAAELRAAQVLAVQRVLARDNWRQLIDGRSADDLYPDAVAAADYAFGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH09</accession>
    <name>A0A010YH09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.587"/>
    <dbReference type="HOGENOM" id="CLU_044208_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="25030" checksum="CA337598FD3E3BCA" modified="2014-06-11" version="1">MTHRVKGVQHVAELIPALAGARANGPQELTGISGWVVDVVELLGPFGVGLLVLLENLFPPIPSEIILPLAGYLSGTGRLNVVTVIVAATLGSVIGALALYWLGAAVGEDRIRVWLRKLPLMQESDLDRAQGWFDRHGGTAVLIGRIIPVVRSLVSVPAGIQRMPLWRFTLYTTLGSGVWNTIFVVLGYVLGNQWKTVGQYSDVLNYAVIAAIVLAVVYFGWKRVLRVRQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHC9</accession>
    <name>A0A010YHC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848454.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.709"/>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="21413" checksum="3D425983F1D47987" modified="2014-06-11" version="1">MDSVPLSDRTASAPGSKPPLPVKIVIAGGFGVGKTTTVGAISDIAPLTTEAEMTEVAVGIDIPGQHSTKTTTTVAMDFGSVAIDAGVKLYLFGTPGQSRFGFMWDDLARGALGALVVVDSSRLDDCYPAVDYFEHTGIPFIVGVNAFDGLLAQDLAAVRWALAIDDQVPVVAFDARDRRSVRDTLLVLLNRALHKAIGEQVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI22</accession>
    <name>A0A010YI22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848700.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.966"/>
    <dbReference type="HOGENOM" id="CLU_007175_1_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458803" evidence="4">
        <location>
            <begin position="36"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="458"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="583" mass="61672" checksum="029B185B5FCB85DC" modified="2014-06-11" version="1">MRPPSNPRVRLRRAAAALALLCAAIGLVPSGPATAAGTASTKVFTADAQPTWQTNGIVWAVTYVRGVIYIGGNFSTVRPPGAAPGTREVARDNLAAFDANSGDLLPLSHKFTSPQHTFSGAKPDVSCDVDWDSQVYSCDTIYRIKASPDGSSIYVAGDFTHVDGQVRTKIAAFGVSRDNAPLDAGFTPTGINSRVRALAVGSRAVYAGGLFTQAGGAARTRLAAFDRSSGALTAFNASADAEVIALSLSADQSRLVVGGNYNRLNGVAQHALGGVNPTTGRSTAWAWRGVPRTSYITDLVADGNAVYMTANGEGTWDGRAAVDPGTGRLKWFDSCLGASWAATLHGDLLYTGSHAHNCNDTDGGFPEQATDMPEPRYYRLLAQTTRGSSTSIQYWFPSTNGGDPNIPATRSVSKLGPRALASDGRSIWVGGQFTTVNNKPQQGLTRFTLTAKSIAPSTPAAPTVQNSGQDQVTVTWRGVEDLDDPTVTYQVYRGSTVVYRVNGSAKPWETKKTYSFVDRGLTAGTSVRYTVRAVDGHGTAGAASPAVTATVGRSAEQPDPWAEDDWGHEREPWSDWGDPWGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI69</accession>
    <name>A0A010YI69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026374_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015597132" description="Beta_helix domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="230"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="592" mass="61787" checksum="3924C7E445815A4E" modified="2014-06-11" version="1">MRLRLVLAVVLAAAAVVLTGPGAASAAPGRTFHLSPLGDDAADGLSDATAWRTLARANQERLQAGDQLLLQGGAQFDGQLLLMPEDAGVTIGTYGTGRATIKAGNLEAIKVYDAGGITIRGLDVVGDATTYDAWSGILFYADDKVATRPSGILISDVDVSGFQIGIAFAGAAPGRGFQDVTIADTRVHGNRDEGLLTYGPEFDATNPSYAHRNVRVQRVAAYDNAGNPRNTTTHSGSGIVLGSVDTGVIEESSAYANGASSASSSEGPVGIWAYDSTGVTIQRNLAYRNRTGTTADGGGFDLDQNTSNSTLQYNLSYENDGPGLLVFTARDNTAHRANTVRFNVSVNDVRGNGWYGALTVAGRVADTAIYHNTIVARPGGGSHRPAAVKLMDGLTGVTLRNNLLLSQSGGAALSAPDFTTEQVLLRGNAYFRAGGGATFEWGGAEYRSLADWRKATGEEKYDTGLDVDPKLQDASATPRVTDPARITDVAQFALAGDSPAAGVGENLDLADDTVDYFGAVLADRPVSIGAAQPASVPSPARPAADRGRLWAVAFTLLTLVGLTVLTAVVRRRRRPPPPVAPETIRVPSSRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIN3</accession>
    <name>A0A010YIN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="67" mass="6856" checksum="5BDD6DDC5B79A00F" modified="2014-06-11" version="1">MTTLRVNGREVEVSDPTTVAVLVRQLTPSPRGVAVAVNGAVVPRGGWAGAQLTDGDEVEVLMAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIN8</accession>
    <name>A0A010YIN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848906.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1165"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="31034" checksum="5F94A7D87304A6B6" modified="2014-06-11" version="1">MIVADRLTKTYGAHRAVDDVSFRCEPGSVTGFLGPNGAGKSTTMRMICGFTPPTQGSSTVNGLPYRDLPNPGREVGVLLDASAQHAGRTGFETLAVSARVLGVDRKRVQGLLDRVGLPPEAAKRRVGNYSLGMRQRLGLAHALLGDPAVLILDEPANGLDPEGIFWMRGLLREFADRGGTVLLSSHLLREVEVIADHLVVIGRGRIVAQGSKAELLSVAGVRVRATNASALGTALQSAGLSATPAADGSFSVDADTETVGRVAAASGLILTELRAADGNGLEEMFLQLTAAHPEGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJE9</accession>
    <name>A0A010YJE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1402"/>
    <dbReference type="HOGENOM" id="CLU_018391_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="512" mass="56398" checksum="90559B72936632B8" modified="2014-06-11" version="1">MLVYAALLLPNREYLLTPKAFVRIPVEAVVGAAVLLVLPGRLRRIVATVAGVALGVLTVIKVLDLGFFAVLSRPFNVIFDWSFLGNAYDFVEGSYGKAAAIGAMVAALVLLVGVLALMVLAVRRLSQTLVDAQPHATKAVAALTVIWFVCAAFGNTVPGLPQTSYTTSLFGYNMFRKVPHALADHKQFQKELAVDRFKNQNQLLAGLKGKDVVFTFIESYGRSAVEDPKYASQVDAVLDEGSAKLKTAGLTARSGWLTSPTIGGGSWLAHSTFYSGLWINNEARYRSLTKSDRLTLTRAFKQSDWRSVGVMPGLTGYWPEGEFFGYDKIYDSRNLGFQGPKPQWSAIPDQYLLSKLQRAELSKAGDTPVVAEIETTSSHAPWSYLPKLADWDEVGNGQATYGGRPRSTKNPDQVRTQYRQTIEYSLRTLTGYAEKYLGDDQVLVFLGDHQPVPLIVGQNASWDVPITIVAKDPKVLDRIESWGWTNGIKPATDAPVWKMDAFRDKFLTAFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJP4</accession>
    <name>A0A010YJP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849352.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1508"/>
    <dbReference type="HOGENOM" id="CLU_106738_10_2_11"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17749" checksum="8FDD9BFD2209B488" modified="2014-06-11" version="1">MPTDAIRELIDRFAVTDVLSTYARLVDERDFAAVGALFTDDCVAEYGVRESDVLRSSAAVTDWLATQLADGTATSHHLSNVTVAFPDADHAETTSYVHAWHGVAGADVDPVVLARYVDRFERTPTGWRIAHRRMFAHGLIGFPDGVIRPLVRREPAAVADGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJY2</accession>
    <name>A0A010YJY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849494.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1610"/>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="244"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36240" checksum="D983B74C907F07ED" modified="2014-06-11" version="1">MTDATPDADARLLEETLFEVKKVIVGQDRLVERLLTALLAGGHILLEGVPGVAKTLAAETLAIAVGGSFRRIQFTPDLVPSDLLGTRIYRSSRESFDVELGPVMANLVLADEINRAPAKVQSALLEVMAEGQISIGGQTHPTPRPFLVLATQNPIESEGVYQLPEAQRDRFLMRVVVGYPDDREELAILYRMGGVRPVARPVLSPASLLRLQDRARDVFVHHALAEYVVRLVMATREPARHGLTDVAAQLAYGASPRATLGLVSAGRALALLRGRGYVLPGDILDVASDVLSHRLVLSFDALADGIAAETIVARIVDAVPRPTIAPSQDQGGPGLGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL73</accession>
    <name>A0A010YL73_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850133.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2045"/>
    <dbReference type="HOGENOM" id="CLU_011142_2_0_11"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="203"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="29676" checksum="994AE8A500CE781A" modified="2014-06-11" version="1">MSLRINTNVSAANAYRNLSVNDKSVSGSMEKLSSGLRINRAADDAAGLSVSEGLKSQIGGLTVAARNAQDGVNVAQTADGALGETSSILQRMRDLSVQAANSGSQDSDAKAAANTEFQELNKELDRIVSSTKFGSQSLLDGSYNGAFQVDSASKNTNAAAQISIDLTSGSADGALGKAGLTGLNAEGLGVKDLDLTTDASAAIDALDTAIKGVSTVRSQIGAIQNRFEHTINNVNVAIENLSASKSSITDTDMASEMVKFSKNQILQQAGTSMLAQANQSGQGVLKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMC7</accession>
    <name>A0A010YMC7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">CryarDRAFT_2486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861949.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2449"/>
    <dbReference type="HOGENOM" id="CLU_053680_0_1_11"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="31178" checksum="517415ABBFB432D2" modified="2014-06-11" version="1">MLSARDIEAAQRKARVLIEALPWLKRFNGAVVVVKYGGHAMTDESLKRAFAADMVFLRYAGARPVVVHGGGPQISSMLGRLGIDSEFRGGFRVTTPETMDVVRMVLVGQVGRELVGLINEHGPFAVGMSGEDAHLLTATRRSATVDGEEVDVGLVGDVATVNPAAVWDLIESGRIPVISTVAPDADGQVHNLNADTAASAIAVALGAQKLVVLTDVEGLYTRWPETDSLVSQIGTEELAQLLPSLSAGMIPKMEACLRAVRGGVPQATVIDGRVAHSLLLEIFTEEGFGTMVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMZ0</accession>
    <name>A0A010YMZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570116.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2653"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_11"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="25883" checksum="EE96125274552A3B" modified="2014-06-11" version="1">MSDITVSRDAAVLTIAINRPERLNSVTTDVLNDLADLILEAGADPDVRVITLTGTGRAFSSGADLKSGAGGKPGTDTIMAANRLIRAVRDARQPTVAVVNGPAVGVGCSLALAADLVLASSNAYFLLSFTSIGLMPDGGATALVPTAVGRARAMAMALVPERIPASEAVAWGLIYQAVDAEELDAAAKALTDRLATGAPLALAAAKKAVNAATLTSLEGALGRELEGQGHLLRTSDVAEAVVAFGEKRPPKFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNB9</accession>
    <name>A0A010YNB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">CryarDRAFT_2799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851101.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2761"/>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_11"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="42345" checksum="EFE30994617C4F25" modified="2014-06-11" version="1">MAKSQFVRNKPHVNIGTMGHVDHGKTTLTAAITKVLADRDPAANRYVAFEGIDKAPEEAARGITITIAHVEYETPTRHYAHVDMPGHADYVKNMITGAAQVDGAILVVSAQDGSMPQTREHVLLARRVGVPYLVVALNKSDAVDDPELLDLVELEVRELLSEYGFPGDEVPVVPVSALKALDGDPRWVRSIADLLDAVDDYVPVPPRELGQPFLMPIENVLSISGRGTVVTGKVERGTLRVGEPVEVVGLGPTVASVATGLEMFGKSLDSAQAGDNAAVLLRGIKREQVQRGQVVAAPGSVTPHQRFRATMYALTSAEGGRHTPFEANYRPQFYFHTTDVSGGLELGDVELVMPGDTLDAVVVDLSKPVALEVGLGFAVREGNRTVAAGTVTELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNH4</accession>
    <name>A0A010YNH4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085077_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="20773" checksum="649A8FEFD81D1E10" modified="2014-06-11" version="1">MIAAAEAPAFAPGAWLYVHPERTRPRPDGDAPRLVLFDRDGTLTVDDPPYNGDPASVRLRPSAREALDVLRAEHVPVGVVSNQSGVGRGLLTRAQVESVADRIEQLLGRFDAWVFCPHAPAAGCACRKPAPGLVLAAADALGVAPGDTAVIGDIGADVGAAAAAGATGVLVPTAVTRPEEIAAAPRVAPDLLAAVHSLLGRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ41</accession>
    <name>A0A010YQ41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3417"/>
    <dbReference type="HOGENOM" id="CLU_070533_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27656" checksum="C7F8B9282DF33128" modified="2014-06-11" version="1">MSADAVRREVADWWATSISRIEPGVVELRGRPVQELIGSLSFPAMIWFLVRGDMPTPEQAALLEAALVASVDHGPQAPSIAAARMAATCGIGLNNAMATGVNLLGDVHGGAGEQCVELLTEVVSSGDAAATVTRWRARDRYLPGFGHRFHPVDPRRDPLLALVDAAAADGVVSGQYATAARAVEAELNRDRTRQIPMNIDGATAVIYAELGFPAPLARGLFVLSRSVGILAHAWEESRSGQRNKGPLPRSIRPTYRHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR07</accession>
    <name>A0A010YR07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3794"/>
    <dbReference type="HOGENOM" id="CLU_069356_38_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21853" checksum="2936266917232292" modified="2014-06-11" version="1">MCNDWVVRTESSRARSTAETRERIVDVALEVLGENPDAGMGEIAVAAGVVRRTVYGHFPSRLDLVRTLTERAVTAMSLVLAEADASHPEADATWAAFVGSVWPVAYRYRVLLALRRGEFGGTIHELLGPIDELLADLIERGQDAGVFGRHVPADVLGQVAYGVVFAIADAVGSHEDLGVRAAIVTSLLTLGVPQARAIALTDGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVL6</accession>
    <name>A0A010YVL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847673.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.198"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="36033" checksum="B5210E0F764677D7" modified="2014-06-11" version="1">MALLEVKDLTVTFGRRGEKPVRAVDGVSFSVEPGQTVGLVGESGCGKSVTSLAIMGLLPKRGVEVGGTAQFEDVDLLKLSTNQMRDRRGRDIGMVFQDPLSSLNPVLPIGKQVTEVLERHRNMHKGEAKAEATDLLTAVGIPDPQRRLKDYPHHLSGGMRQRALIAIALACRPRLLIADEPTTALDVTVQAQILALLERLVDEVGSALILITHDLGVVAGLCDTVNVLYAGKVVENTDRYRLFAQPRHPYTSGLLGSVPRLDAPRGQALTPIRGSVADALPWSEGCAFAPRCDNKIDTCVSSTPQLEPDAESRRLLRCFNPVEKPAVVEEVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWJ5</accession>
    <name>A0A010YWJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569646.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.551"/>
    <dbReference type="HOGENOM" id="CLU_005639_0_0_11"/>
    <dbReference type="OrthoDB" id="273651at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="990" mass="102176" checksum="FE000B3C2245E451" modified="2014-06-11" version="1">MPDPFGLSERRAAVLASWAGVATRFREDANAEEELVRGGLGGYADRLVVELAQNASDAAARAGVPGAVRFTYADGVLSVANTGAPLDSSGVDGLTSLRASAKTASGGARRTSTVADAERPAAGPRTVGRFGVGFAAVLAVSDEPSVHSRDGGVRFSAEQTRAEVAALGGAAAEELARRGGAVPVLRLAWPVDSPPPAGFETEVRLPVRPDAVEHVRALLADVEPTLLFAFPGLTRVEIVLDGVERVIERVGAAEHTVSLASDGAVTTWLVATADGEVPPELLAERPLEERAALAHYSTLAAVPLDRGAWVGETVLHAPSPTDEPLSLPVHLAATFPLEVSRRRVAPGALTDWLAARAADTVVALLVAAPPSVEALALVPRPGLGRAPVDAAICSLVLSGLRETPFLPLENVPDESSVSGLPWTDDDLGLLADTFAAAFGTAQPPAAAASTSDASTSDAGSAGGASWERVTPARAVTLVPELAGSASELVAALAGVVPGLLPADWAGRAAAPALDALGVRRLGVADVVEAVAGLDRPAAWWGDLYHALEPSSRDLDALSALPVPLTDGRTVTGVRGTLLPGPDLAALAPATLEPLGLRVVHPDAVGSDLLIRLGARPATVATILADERVRAAVADSIEADDPEPLANAILTLVTAAGVRPGEEPWLAELALPADDDWYPAGELVVPGSALVRVLAGMDTDDAPFGVVDEDFANDVLAAHGPDALPAIGCLTTFTVLEADDLDLVDLMDLDADDADLDLDGLAEWVDAAVDTIDPTGTVGAPPGTRVERFRAIRDLDLVDADQWPAALELLASGPPREVLDAPAYAVTPDGTRIEIQSYSRWWLAREPVLDGRAPGELRTPDAVDLDGLYDVAPDDVDTALLPLLGCRTGLLDAIAADPGDLLHRLADADRTAAPWIVPLVYARIAEALAGARVPAPARVRVAPDAVADTDQVAILDQPWRVDALDGRAPILGGDDPVSVAELLDVPLVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWY6</accession>
    <name>A0A010YWY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.697"/>
    <dbReference type="HOGENOM" id="CLU_071330_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="24088" checksum="9698FFF620CF097B" modified="2014-06-11" version="1">MKTILFGATGMVGQGVLRECLLADDVTEVLSVGRTPLGRTDPKLRELLLPSLDDLTTVADQLAGYDACFFCLGVSSVGMDEAEYRRITYDLTLGVARLLAERSPNSTFTYVSGQGTDSSEQGSTMWARVKGKTENDLLTLPLQTYVFRPGFIRPMNGEGPKTAAFRWGYRLLAPVTKLGTRVFPKYATTTEAVGRAMLRVTRENPPTRVLGNPEITRLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX12</accession>
    <name>A0A010YX12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725656.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.723"/>
    <dbReference type="HOGENOM" id="CLU_040769_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="39586" checksum="1D60AE50FDD95E26" modified="2014-06-11" version="1">MSESRKFPNVAELMRPSGYGMQVTLITLVAVAVAVLASMGLVSATGGSPGDALNALYTGSIADTAAWSETLKAATPLLLVALGACISNRAGVFNIGQEGQVLLGAAVAAYVALHLALPGVLVMVLSLLAGAIAGGLWSGASAVMHYTRGVNVVVSTLLMSFLAIQLVSFALTVQWLLQAPRASADSIASTESAQLPPAVRIPGFGEYPALEIGGGLVLSIILTIVLAVLLARSRWGFRLNMLGLNPMAARHAGVRAPWAGGMALALSGAFAGLAGAVILSGQVFRLQPALSNNFGWDGLLVALIARSRPLAAVPVALLFGAFRSGSSFLASTGVPNYLVDIVQALLVLAFVVPPVLAKVKSRGRAEATPPPTEPVPSTPTEPEKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX51</accession>
    <name>A0A010YX51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848496.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301117_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="10424" checksum="A359711F42D5F350" modified="2014-06-11" version="1">MTANPSDATPSDLEARDAAARDAVPNPEAPDVTGYLPEIDARPAEKPRPAIPPIPKWVVPAVAAVLVFGLLAFPFGWSVWAALIGAVAAGAISYAFVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX61</accession>
    <name>A0A010YX61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.771"/>
    <dbReference type="HOGENOM" id="CLU_112849_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="16618" checksum="46B25399F57FD3DC" modified="2014-06-11" version="1">MPTEINGLPAHVLLVHFVVVMIPITALMLVASAFWPNARHRIGVVLPIAALLSLISVPVTANAGDWLRQRMGGGSPQVAQHAHFADQLLPWTIGLFVVSVAVWAVHRFVPAARSGSSKTALTVGLAVLAVVVAVGSVYATYRVGDSGAKAAWDGVIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXE1</accession>
    <name>A0A010YXE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848623.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.873"/>
    <dbReference type="HOGENOM" id="CLU_096072_4_0_11"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="15162" checksum="FF41132E34DBD8DB" modified="2014-06-11" version="1">MVEENTRAQLRDAGLRVTAQRASVLDALRDQPHVTADAVARWVREHGVTISTQGVYDVLDALTAVGLTRRIEPAGSPAVYEARVGDNHHHLVCRTCGTIVDVDCVVGSSPCLTPADSHGFAVDEAEVVFWGVCPECLRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY28</accession>
    <name>A0A010YY28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848900.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1158"/>
    <dbReference type="HOGENOM" id="CLU_020520_0_0_11"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="7">
        <location>
            <begin position="13"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="27935" checksum="1951AD2C5301B1A6" modified="2014-06-11" version="1">MNPVVALTVAGSDSGGGAGLQADLHTFAAFGVHGTTAVTAVTVQNTVGVTGVHEIPPTFVADQIRVVVEDMRPGAVKTGMLASAPIIEAIGAAFRRHGIGRGGSIPLVLDPVCASMHGDPLLRADALTALRELFALATVVTPNLDETALLVGTRDQRSAARALLDLGPAYALVKGGHGDGPRSQDLLTDGTMELWLDAARIETGNTHGSGDTLAAAITARLAGGDTPADAVTAAKRYVTRAVATSYSVGAGHGPVGHPPASDPVGTPGPLATPSAVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYJ9</accession>
    <name>A0A010YYJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase, FtsK/SpoIIIE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569840.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034934_1_1_11"/>
    <dbReference type="OrthoDB" id="1108224at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="49502" checksum="AC29FE41CD2908A8" modified="2014-06-11" version="1">MFLLALVILLRRGPWPAVRFLVKAWLWIVGSIVWLVLFFRRPTAALLLLVALLVALVLWRLRGWLWGQLWRWKGDRIAAVIPDRAWVWVRRFQWPQLAWRTGLTRPQAVGAGASMEYLGGRWRPIPNGFVVVGRLLDGQTPVDYAKVSEPLAESWQVARVAVDSPARGWVRLKALWSDPLATPLRAPLPNPRPDLRALLLGQREDGLAWTERLIGRHLLVAGATGAGKGSVQWSVIRALAPLIRWRVVEVWTLDPKRIEFASGGRLFARYAAEPVDMVELVEAAAQLVADRARRMAGHARTHVARRGDPFVLLNIDELAFLTAYLTDRKLKDRFAGALATVLTQGRALGVAVLAAVQDPRKETVPLRQLFTTRIALRLDEPSQVDLVLGDGAADRGAAAHLIPRDEATGAGIAYVITDGDATPRRVRAGYLSDRDIAWTVATFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZI6</accession>
    <name>A0A010YZI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1678"/>
    <dbReference type="HOGENOM" id="CLU_078469_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="22724" checksum="7122AA2FE7BCC173" modified="2014-06-11" version="1">MTALDGPDAGLDALTALTDATRRAAYEAVLAAGARPLGRDEIAELLGVGRTLAAFHLDKLVDAGLLEVSYGRRNGRSGPGAGRPAKLYRVSATEHAVSAPPRDYRTAAELLAESVERSGADTALFEVAREHGRRASSGGDVRARLTAHGYVPEETPTGFRLNNCPFHRLAEQFPPLVCGMNLALISGLLDGTDWTARMDAAPGRCCVVVSKNNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZV3</accession>
    <name>A0A010YZV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class putative F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849764.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1785"/>
    <dbReference type="HOGENOM" id="CLU_125990_1_0_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="14275" checksum="0F2E04C2305E1965" modified="2014-06-11" version="1">MIFDDAEREYLAGQRLGRLATVDADGRPQNNPVAFTVDDDTGAIDISGYDMGASRKFRNLRHNSGVAFVVDDIASVHPWRVRGVEIRGDAEALTGQPPANSYVSGEIIRIHPRWILSWGLGEQRGSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0S1</accession>
    <name>A0A010Z0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570008.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2109"/>
    <dbReference type="HOGENOM" id="CLU_026490_1_0_11"/>
    <dbReference type="OrthoDB" id="1068352at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="413" mass="45222" checksum="96B4AA6A5469D19B" modified="2014-06-11" version="1">MHGDDIQALAGPLRTAGDFDPLLDRIGNARIVMLGEASHGTHEFYCRRAELTRRLIDERGFSFVAVEGDWPDCDRVDRAVRGSASPRQALTEFDRWPTWMWANEEVCDFATGLRAANLIRANPVGFHGLDVYSLWESLDEICAYLREHDPANLPAVLAAMGCLAPYGQDPQQYAWATVMGSTCAPPLVELLTTLRYRTTDLGILQNAEAAVGAENYYREMVSNGPESWNVRDVHMVNTLDRLLQHYGPGSKAVVWAHNTHIGDARATDMADVGMVNLGQLGRERWGDDAVVLVGFGSHRGQVLAGPAWGAPVEVMPVPPARAGSLEAILDASVPEPALFVLPSGPRPRWLTDTLAHRAIGVVYRPSREAYGNYVPTRLGDRYDAFVWLPETTALAPLPAVAVGSELETYPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1M6</accession>
    <name>A0A010Z1M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="12" type="ORF">CryarDRAFT_2429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850602.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2392"/>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_11"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="896" mass="96356" checksum="9C828194B9021C8F" modified="2014-06-11" version="1">MKTSEIRQRFLDHFANRGHTVVPSAGLIADDPNLLFVNAGMVPFKPYFLGQVTPPYPRATSVQKCVRTLDIDEVGKTTRHGSFFQMNGNFSFGDYFKDGAIRYAWELVTNSIADGGYGFDESKLWVSVYEEDDEAYRLWNTEVGVPESRIIRLGKGPNFWSMGVPGPCGPCSEILIDRGPEYGPEYVNTPGVEPDGDRYLEFWNLVFMQYERGPGQGKTDYPILGDLPAQNIDTGMGMERVAFLLQGVDNFYEVDEVRPILDRAAALSGKRYPAHEQHDGHPNPDDVRLRVVADHVRTALMLIGDGVTPGNEGRGYVLRRILRRAVRSMRLLGYEDPSFPELFPVARDAMKASYPEVETDYTRIAGYAYAEEDAFRTTLRSGTTILDTAVASTKSGGGSQLSGASAFQLHDTYGFPIDLTLEMAAEQGLTVDEEGFRRLMSEQRQRAKADALARKTGHADTSVLRSILDRTGPTNFTGYLEVEREGRIGGIVGKDGAVRGGAGQGEEVEVVLDATPFYAEGGGQQPDQGVIVTPGGKFEVFDVQQPLPGLYVHRGTVVDGEIKVDDPVLATIDVDRRRAISRAHTATHLIHTAIRGALGESATQAGSLNAPGRLRFDFNTPGAVPQSVLSDVEDEVNAVLLDDLEVRAFITSQAEARRIGAMALFGEKYGDEVRVVEVGEYARELCGGTHAARSGQLGVVKLLSEASIGSGVRRVEALVGLDAFRFLAKEHLLVSKLAEQFKAKPDELPDRVASVVAQLRDAERELEKLRAAAVLSGAGDIASRALDVQGVAVVAVEAPEGTAGNDVRSLTQEIRGRLAADRPGVVAVAARANGKASLVVAVNQAARDRGISASALVKGALSGRGGGSDDLAQGGGVPADAAPTVLASISELVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1S1</accession>
    <name>A0A010Z1S1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">CryarDRAFT_2479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850665.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2442"/>
    <dbReference type="HOGENOM" id="CLU_169643_4_2_11"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="7392" checksum="2EDCD0A5DA21ADC0" modified="2014-06-11" version="1">MPKNKTHKGTAKRVKLTGTGKLRRQKANRRHLLEHKSSTRTRRLDGTTDFAPTETKRIKRLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3L9</accession>
    <name>A0A010Z3L9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4365 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570263.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265979_0_0_11"/>
    <dbReference type="OrthoDB" id="1992940at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025375">
        <property type="entry name" value="DUF4365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14280">
        <property type="entry name" value="DUF4365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4365" evidence="1">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135005" checksum="B5ACC2FD4E398C5D" modified="2014-06-11" version="1">MAEEGLDSENLGRLGMNIVERIVLLSFRWAFRDQTMMDAGIDAHVEVKDAGFGHTGRLLALQIKCGRSFFTKPSGEGWSFPFNDRLAKLWTGHALPVIVVLVDPDTSVAYWQQVTPQTVESTGKGNRIVVPRVNTVSTAADVWNHIASGIEREAQLRYDQLLTVLPPATVGVLERLHADRPEDGAVLAVHLADGRGQPEDTVKVLLSASPIWLTRAGGDGWRAVANYALAHDHPELASVAFERAAADQDGSQKGRLLVAAALPLLHEDRARAADLLTRAERLDGAQILVSLAKAILDHPHADASAWTLPPDLDLASDQVQQDGVVQAILAGHAVQAGDLNAAIRYGSTALELQPDDTAIMMMLADAYFRRSQSSRSEPDDLQRACAQLIRVVEQRHRWSGPTGEPLENLLRQLGVSEDYEAMLRHAVGPPFGEALPDEADRPVVRQHAVMAALTLGETTLAQRLADGLDESPRAQTLAARARGEEIAPGRLVDLWTQAFAAAESAGDAWRVVDAAMQLAELGVDVSGRLTQLVERSMITAIVQRRIHAIAEAEQHLDSAIPALRALTPTDPTAAEALISRLALAGRLDEALAACDLAQRTLRQPVFTAQRAYLLRQAGRMEEAESAARDALADPHLGPSDRRRLLTFLVERALDRRDGRDAERHVMAAIRTMTTPSRWLVWYLVHAQLMQLDPSRAATTLRHYRPQAERPTEGRAWLQAMAGETWDPLDAKQALAMATGFRNADPPLAAGLLTALVRNTRTEPHPQTEDTDAAELVAIDDLESGDPRSMVPDDLYVAAFGALNDLIDAHGPLLGLRRVDGSLDALAAELAESASARDHSQLAELVERVRAGRIPLGMLATMLGIPYGLALIQRASGVQVAASVADAEHDADVQAAAAALNTHVAVETSALMLLSQLSHGEELIGRFAGLHLPFDSRRDIILARIEARGEAAGAGRLGWDEHHGQPIFYPLTSTERLTMLRRANALDQISAHTLYEPVDALPDLRDADPAVFGPWAGPIQLARTNGWTLWSDDVAVRQFARALGVPAFGTPALIEALTVRSIEEVLASTGDQKRVDALLAWQHEAVRVFVAEFIVDVPATLGDVLAQAAADGWTARAGAAVLTRPSWWLWQEKPLANLLTIYEHVTQHEPDALPAWQMAAMEGLAALFLTDPQTAYVWITAIALLGFAAPPGTAAIEGGLSRATAIAHRRQLLSPPEPLTLAVDLLTEHGVVADPEAFLAEVHLELGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z502</accession>
    <name>A0A010Z502_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725727.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3572"/>
    <dbReference type="HOGENOM" id="CLU_142057_0_1_11"/>
    <dbReference type="OrthoDB" id="1753156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016944">
        <property type="entry name" value="UCP030066"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030066">
        <property type="entry name" value="UCP030066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="15828" checksum="DB5E12373BBF2948" modified="2014-06-11" version="1">MAARKTYWSTTIVLVFVLFTGGIADLVRAQATAEGVYQLGYPPIFLTILGTWKVLGAVALLAPRYPRLKEWAYAGCFFNFSGAVVSHLVAGSAVSHVVITGALAAVTLVSWATRPADRTLGVLDVAGRTIDPTTSPRRIPVKPDALPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5G6</accession>
    <name>A0A010Z5G6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="6" type="ORF">CryarDRAFT_3781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852490.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3749"/>
    <dbReference type="HOGENOM" id="CLU_139869_0_1_11"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="11520" checksum="B4C3C2DEA99D0589" modified="2014-06-11" version="1">MAKKSTVARDTRRRVVVARHAARRAELKRVIGNPRSTDDERTAARAELTRQPRDASRTRLRNRDVVDGRPRGHLRAFGLSRVRFRQLAHAGELPGISKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6F3</accession>
    <name>A0A010Z6F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852899.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4054"/>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="36512" checksum="30A954C74F6546F8" modified="2014-06-11" version="1">MSKGSCATRTVALIVDEHSNPFEVGCATEIFGISRRDAIGFEPYTLTVVTPRPGVRMRDGLFQVSAEGRLADVVSADLVIVPNRPAVELTSRPAVLRTIRRAHERGAHLIGLCTGAFTLAEAGVLDGRRATVHWQLAAEFRRRFPAVHLEPDVLFVDDGDVLTSAGSAAALDLGLHVVRRDFGAEVANHVARRLVFAAVRDGGQRQFVEQPLPPPTVNSLAPVLEWASANLHRRLAVDDLARRARLTPGTFHRRFRREVGSTPVEWLTAQRVALACRLIEQGASGVESVAHHAGLGTGANLRSVFRRHLGVTPSEYRRRFAVRPGPAQPRTNVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKF8</accession>
    <name>A0A010ZKF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="4" type="ORF">CryarDRAFT_0157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.150"/>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_11"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="36124" checksum="9138E57261AAFD5B" modified="2014-06-11" version="1">MSSTESLRSTPPTGDVPATFSPDQRTVDWADGAVELIDQTALPAVERLLRLETVEDVVDAIQRLAVRGAPAIGVAGGLGVALAVRTLPEPSAAIRALRDARPTAVNLARAVDRVAAVVPDGADAVLAEALAIRDEEIASSDSMAAYGVELISELCAAQPRLLTHCNTGGLATVTGGTALGVVFALHRAGLLGGVVASETRPLLQGARLTTWELGRAGVPFRLAVDGAGAYLMARGEVDAVIIGADRICANGDVVNKIGSYAHALGAARAGIPFVVVAPESTVDPATRTGAEVEIEDRGGAEVSGFGVAAANPAFDVTPFDLVTAVVTDRRVVRFAAGQTWDDVPLGPLRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL00</accession>
    <name>A0A010ZL00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569591.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.322"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="298"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="57921" checksum="6BE1B454A6361824" modified="2014-06-11" version="1">MNSGTGEWTLRRRLLTTFIVVGAMTAVIAGLAATALGRVIDRNNDLLGRIGPARLSGYQLESALLDQETGVRGYVLTKQATFLEPYDEGLNDQRAHLRTIRDSIPEDDGLHDDLDRVDGAINAWRSRYADPAIAAARTGRTATTTVDDEGKALFDAVRKAIATFQNDLTDIRNGIYDDLQSAIRTLIAVAVVALLGILIAGFVLWRALGRWVLQPLERIGAETKQVVGGSLTHKVTVDGPQEITAVAADVDAMRHSLVAALSTAVAAQDRLKEQTDQLAAQTADLQRSNTELEQFAYVASHDLQEPLRKVASFCQMLSRRYSGQLDERGQQYIDFAVDGAKRMQRLINDLLAFSRVGRTTGEFEDVALDSVLDRALTSLGSTIEESDADVQADVLPHVNGNPILLTQVFQNLIGNAIKFHGMAAPRVRITVEQKDDTFEFVCSDNGIGIEPQYAERVFVIFQRLHGKEQYDGTGIGLAMVRKIIEHHGGRIWLDTESAAGGGTTFRWTLPVPSELEAATTGVGAVRTESNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM37</accession>
    <name>A0A010ZM37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase with GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569707.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="460"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="678" mass="72724" checksum="8770D4B6258C6A92" modified="2014-06-11" version="1">MSVDTTARVLDPERLRVLTETGLLDSPSVAVLDRLTSLVTRVTGAPVALVSLVDAGRQFFVSAVGLPEPWRERRQTPLSHSFCQYVVSADAPLIISDARADELLCTNLAIPDIGVIAYAGFPLRSPEGRPLGSFCVIDTRPREWSQADLGVVADLAAAVESEIALRLSHTRLLRARKAEARTEQLREVQHAVATSLAEARSSTDAAARTVTAVAGELGWAHGEYWQLGDDEQTLTRIAARTAPGWDAADFSGGSGGFAAHVRATAVPTRVPEAAAPAEATGLGLPVRSGDRVLGVLVFHHDEPLGCDAELLSRLDSVGAHLGRFIERRRADAARRAFERVVSGIDDYVWTVEITPDGALQPVFGSANEAAVFGADLRATPLADLVDPRDAARFAEFRGTVLEGRPGNLEARFIGADGVTRWVWSRAVPRFEEGRVYVDGISTDVTERHRISEQRDELVALVTHELRSPITSIRGYLELVFDDEGSYSPSAEGFLRIVDRKAADLQRLTDDLLDLARLDAGEISVDTRPVSLARLLGDVITDLRPAAEAKHLTIDVVTDGPIVVCVDPARFRQVLTNVVSNAVKYTPDGGRVIARAGAADGVATVSVADTGIGIPADQYPRLFERFFRTSNAVQEGIKGTGLGLAITKAIVERHGGTIAAHPGEPCGTVFEITLPEASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNB5</accession>
    <name>A0A010ZNB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848969.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1221"/>
    <dbReference type="HOGENOM" id="CLU_007946_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="524" mass="55277" checksum="180B2F6C40192334" modified="2014-06-11" version="1">MSTTKDVSAESEGLTPHEVHRLKPGTIGLWAVLFIALANAAPITAMTGNVPIAIGFGNGLGAPAGFFFATVILTIFAIGYVTMAKHITTTGAFYGFISHGLGKVWGMGAGLMATLAYIVFEASLIGILASFTKSTIETFGGPSISWLVYALIGIVIIAALGYFEISLSGKVLGVFLVAEVIILAALAISILVRGGGPSGLEAGAINPVNAFSAVASDPQAAITGSAAIGLFFAFWSWVGFETTAVYGEESKDPKKIVPRATMIAVIGLGLFYVFVSWMAIAGNGLDQAIAISRGSTGNAFDLFYGITDRFLAGWVKDVYLVLVVTGSFACALAFHNAASRYLYALGRDGVTSGLRRTLGSTHGKHGSPHIASLVQSVITVVITLGFFFLQKPTDAAPDVAYIHQYGLMAIMGTMALLIVQSICSIAVIWYFHVRKQHPETASWWRTFLAPLIGAVGMLYVVYLLFSNIDFAAGAAAGSPIFKATPYIVIGIGVLGALVALALKYRSPERYERIGATVMAESHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNF4</accession>
    <name>A0A010ZNF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569826.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="392" mass="41801" checksum="031AB543A1F86002" modified="2014-06-11" version="1">MIGDTARVTRSASADEYRDPADDAKVGATIGVEEEFHVLDPTTGELVPEALTLLANPTPGEHEPEAELLRSAIETATPVCRSLTEVRAEVVAARRALIKAAAEHDVAVATAGTVPDSGVRPMGVFPKERYRQMAAEYQQLVREQAVCAFQVQVGVPNRDLAVAVVSHLQPWLPVLLALSASSPFFANTDTGYASYRTIVWSRWPTAGPVHGFRSAAEYDRTVDTLVGSGIISDPGMVYFDARPSARYPTVELRITDGCPRVDDVVLLTGLGRALVVTAANEIESGVAPVSARPELLRAADWRAARSGLHGELFDPVVGTAVPASDAVRALVEYVGPALDANGDTDEVRILLADLLARGTSADRQREALGRRGTFGDVATLLIEETRGGVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNP4</accession>
    <name>A0A010ZNP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in acetate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">In the N-terminal section; belongs to the CobB/CobQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="5 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849117.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1338"/>
    <dbReference type="HOGENOM" id="CLU_019723_3_0_11"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016475">
        <property type="entry name" value="P-Actrans_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006107">
        <property type="entry name" value="PhpActrans_proteobac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="13">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="12">
        <location>
            <begin position="362"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="686" mass="71518" checksum="79E68351EF9831FC" modified="2014-06-11" version="1">MSDILYLTSMEPRSGKSAVALGLLDLLAADVRRLAVFRPVVPDHSRPDPIVELARQRYDLEIAEDDAVAFTYSTAAELIEAGGPQKLIEAIVDHVARLRERYDFVLCVGTDFTGPSPAVELDLNADLAANLGAPVIQVLSGHSRTADAVSTALREGAAVLKTHGCEVLATIVNRAGPEHGNLACATPPVYVVPDLPVLAALTVAEVVAALDGTLLSGDGPALQREVDSYLAGSAYLQTVLPLLKDGTLLVSSGDRIDLAVGVAAAAVSPDLPTPAGIVLTVGHVPDERSLKLLEPSGLPVIAVKADTYTTLHRLEGLTGQLRADSARKVAAALGAFADHVDTEVLRTRIQLAKPDVVTPHMFSAQLIARARADKRTIVLPEGDDDRILLAAEELTQRGVADLVLLGNVEQITAKATQLGTDVTNVRIIDPLTSPLRDAFATTYAELRAHKGVTPAMAYDVVGDVSYFGTMLVHAGEVDGMVSGAAHTTAHTIRPALEVIRTLPDVSLVSSAFLMCLPTKVLVFADCAVVPDPDAAQLADIAVCAAETAVKFGVEPKVAMVSYSTGQSGTGVDVDKVRAATELVGAKHPDLPLAGPIQYDAAVDPAVGAAKLPGNPVAGHATVLIFPDLNTGNTTYKAVQRAASAIAVGPVLQGLRRPVNDLSRGCTVADIVNTVAITAVQAQGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNR2</accession>
    <name>A0A010ZNR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)alamin adenosyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849140.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1358"/>
    <dbReference type="HOGENOM" id="CLU_088595_0_1_11"/>
    <dbReference type="OrthoDB" id="1690483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="22567" checksum="F18C92505288F82B" modified="2014-06-11" version="1">MPQGKPTTVPNDGLTTRQRRRRPILAVHTGPGKGKSTAAFGLALRAWNAGWPIGVFQFVKSAKWRVGEEDALTALGEYHAQTGTGAPVTWHKMGEGWSWIQRAGTEQDHARDAAEGWEQIKRDLAAENYGLYVLDEFTYPMKWGWVDVDDVVETLGNRPGSQHVVITGRDAHPSLLEAADLVTEMTKVKHPMDAGQKGQKGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPP4</accession>
    <name>A0A010ZPP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849637.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1703"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="33271" checksum="3931D852DA3F9E9F" modified="2014-06-11" version="1">MNTFGLGAMAMSDAYGTSDRAESIATVQAALDAGITFVDTADFYGNGHNELLLASALRGRPRDGYVLSVKFGALRDPDGTMLGFDGRPASVKNFLSHSLSRLGVEYVDVYRPARLDPAVPIEDTVGAIRDLIDAGYVRSAGLSEVGAATIRRAHAVTPIADLQIEYSLLSRGAEAEVLPVLRELGIGLTAYGVLSRGLLSGHWRPGTAGDHRNLMPRFSAGNVAHNLALVDALRRVADAKGCTTAQLAIAWVAAQGADIVPLIGARTRERLAEALPALELELSADDLAAIERAVPAGSARGDRYPTPMMAQLAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ98</accession>
    <name>A0A010ZQ98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR01777 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849941.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1897"/>
    <dbReference type="HOGENOM" id="CLU_047373_0_2_11"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="31547" checksum="BDE6AFA6AD4CC34D" modified="2014-06-11" version="1">MRIVVSGASGLIGTSLVDDLRRDGHEVIRLVRREPTGPDQLRWDPAAGRLDPAALSGADAIVHLSGAGVGDRRWTSRYKATLIDSRVDSTRTIATAAAQAEKPPKVLISASGIDAYGDTGDREVREDEPFGTGFLADLCRVWEAATGPAENAGIRVTHLRSGLVMGPSGGLMGRLKPLFKAGLGGRLGSGRQWWPWISLRDEVAAIRFLLTADAVAGPVNLVGPELVTNAEFTAEFARQVHRPALAPVPPFALRLALGDFADNGILSSKRAVPGVLLDHGFEFTDATLASALRYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQE9</accession>
    <name>A0A010ZQE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848084.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_2_11"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="18744" checksum="C4C8FA01D77C8BAD" modified="2014-06-11" version="1">MSTEPEYADRSAALLALYDRVLPEVYGYLRARCVSTAVAEDLTGETFLAAVTAVRQGTSPTAAWLITVARNKLVDHWRREAREQRTLHVVERPDDPWDARLDVLRAREVLRRLGPANRAALTLRYVDDLPVPEVARLLGRTRHATEALIVRARAAFRVAYEEGEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQR6</accession>
    <name>A0A010ZQR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid-responsive transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850172.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2078"/>
    <dbReference type="HOGENOM" id="CLU_067515_1_0_11"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="32946" checksum="7E1760FB2F77C959" modified="2014-06-11" version="1">MTTVQLPRRQAGTSPQHLLVTLLGDYWNGRREHLPSAALVALVEEFDVGEVSARAALRRLARRGVLESSKVGRNTYYGLSASATRTIVQSSKRIVHLGTREESWDGVWTVATFSLPEEQRDLRHLLRSRLRWLGFAPLFDGVWVSPRAATAEVREFLDELAISTAAVMRAEEAVGTPLISAWDLDEIRHAYESFLADTLPLRERLDGGDVGSAEALIARTRLMDVWRTFPALDPDLPERVLPADWPRRRARVVFGDLYDALGPLAEARVRQVLARFDAALAPLVRHHTTTELTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQX2</accession>
    <name>A0A010ZQX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850229.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2135"/>
    <dbReference type="HOGENOM" id="CLU_129336_1_0_11"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17890" checksum="BF04663DEE38CDCD" modified="2014-06-11" version="1">MDTDDQAITELFDRLKQAWTDNDAEEYGACFTEDSDYVSYDGTRAIGREPMQRAHDDLFRGVLVGSALVGEIESIRYLCPEVAVVHGTASVLMPWRSVLPKRRSSRQTLVVVRTSEGWRFTALHNGRVRPVAIPAPDSVPSRMARSMGSVARAVGIGRGAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR59</accession>
    <name>A0A010ZR59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850358.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2224"/>
    <dbReference type="HOGENOM" id="CLU_063440_10_0_11"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="110" mass="12009" checksum="9C7C6C024E3E8756" modified="2014-06-11" version="1">MDSPPRLTTGMARVLAAFLDDPSSDRYGLDLMRATGQPSGTLYPILLRLQRAGWVTATWEDVDPAAAGRPARRYYRLTPEGLETARIELAALRQQLGGSGATVRPNPRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRA6</accession>
    <name>A0A010ZRA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848503.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.763"/>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_11"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="XFP_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="5">
        <location>
            <begin position="596"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="806" mass="88806" checksum="8585389E29D3BB84" modified="2014-06-11" version="1">MSLGTDTTAIDLAERVRQLDDTDLARVDAWWRANNYLTVGQIYLQDNALLREPLRPEHIKPRLLGHWGTSPGLSFLYAHLSRLIRITGQQALYLAGPGHGGPALVAAGWLEGTYSEVYPRVGRDGSGLHRLFRQFSAPGGIPSHVSVTTPGSIHEGGELGYVLVHAFGAVMDNPDLLALAVVGDGEAETGPLEGAWKGISFLNPARDGAVLPVLHLNGAKISGPTVLARKDPAEVRELFSGHGYDVIEVEGSDLPGMHHGFAAALATAWAAIRRIQESARDGGWDGSRPRWPMIVLRTPKGWTGPEVVDGTQVAGTFRAHQVPLSGVKDNPEHLAQLERWMRSYRPDELFDENGTPNADVLAANPAGDLRMSATPHANGGLLTRDLDLPDFRDYAIDVEAPAGTRAESTRKLGELMRDIYARNPDRFRLFSPDETNSNRLGAVFEVSDRAWAEKVYDSDISLSHQGRVMEVLSEHNCHGWLEGYTLTGRHGLFGTYEAFAMVSASQTVQHSKWLEEASHLSWRAKVPSLNILLTSTAWRNDHNGFSHQGPGLIQTVLTQRGTVSRIYLPPDANCLLSVADHCFRSRSYTNLIVIDKQPQLQYLTIDEAIEHCARGAGIWEWAGNDDGTSDPDIVLACAGDVVTMETVAAAQILTERLPHFRTRVVNVVDLMALQRPKDHPHGMEPMLFRELFTDHVDVVFAFHGFPGAIHQVVHGRPDADRFHVRGFIEEGTTTTPFDMTVKNKASRYHLVIDALNNARRTPPGASELKAWCEAQLAKHEQYVVEHLEDMPEVADWVLPARGTAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRE8</accession>
    <name>A0A010ZRE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.785"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="381"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="521"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="775" mass="82803" checksum="33726AC7895E7E8A" modified="2014-06-11" version="1">MARSASASSDTKNGWIVALIGGAVAVGVVNLFPDDTRPIACSVVEIATLAVFAIGLRLNRPPQRVIVVLVFGAVTLVTVTKLARRADTVFDPGFSLPTPVTDWLYLISYLALALALGILPLHGRRQTKLTSVTEGGILACTVVVLAWSGVIDPALDSSRIDPVVAVTASLLPMLGLLMVTTIARRLLTLGRRSPAGILTVVALLVLLTGDTASMATRLDEGVVAGPQPSMLGWLVATVLIAAAALHPSAAVEPLPAQRNRRGVIARGYVLLILVGPAATALALVREMNHGFEVDVLDVVVPLVATTVTAILLVFRLTAFARVAEQRATALDTRTDALETALAEQVTLRKVLSHQATHDPLTGLPNRMLFNESVDEALTEGQPGSLLLFDLDGFADVNDRYGHEVGDDLLLAITERLLTTVPPPHTLARLGGDEFAVLLSRTDEAASLRHAQEILAALRGPFQVGAYQLYTAASLGLRPLDPETGTARLLSDADLALYAAKAAGRDQLVSYDPQLRTRHLAQARMVDRLRDALEHDQLSVFYQPVVDLASDRWVTVEALARWETEEWSVSPDQFIPAAEDSGLIVALGTFVLRQACRDAAVWHREHGTRLAVNVSVHQLRDAEFANTIRSALTDSGLPAQALSLEITESVLVGAGTQRAQAIAHLTELREAGVAVAIDDFGTGFSSLAYLQTLPIDTIKIDRAFVPCGEVYDSQQFALVRAIVQLARGLRLGTVVEGVETPQQARILRLLGCGLGQGYYYSKPVPAAEISASLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS93</accession>
    <name>A0A010ZS93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase, carboxyltransferase component (Subunits alpha and beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569793.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1133"/>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_11"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="270"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="528" mass="56270" checksum="5406605DDB279AC7" modified="2014-06-11" version="1">MTTTDLPRTAQGTAAKIAELARRREVARQGARSAVEKQHAKGKLTARERIDAFLDPGSFVEVDEFARHGAGAYGDDTREAYGDGVVTGYGLVDGRPVCVYAQDFTVFGGSVGERVGQKIVKVMQRAIEVGCPIVGLNDSGGARIQEGVASLAAYGEIGYHIALASGVVPQISLILGPCAGGAVYGPAATDVVVMVENTSHQFVTGPDVVRAVTGEDVTFEELGGPAANAEAGNVHYVATDEQDALDWVQSLLSYLPSNNLDEPPDFGAADLEISADDLALNEVVPDEPNRLYDMRRVVRHVVDDGEFLELQAAFAPNLLVGLARIEGRTVGVVANQPLHLSGALDIDASEKGARFIQFCDAFNIPILTLVDVPGYFPGLAQERGGIIRRGVKLSFAYATATVPMVTVIVRKAYGGGYASMGCKHYRVDANLAWPTAEIAVMGGEAAVSVLFRRQLQEAAATGDVESLHAALVAAYREQRCTPYEAAERGYVDAVIAPSETRTEVAKALRMLRTKRQASPARKHTNFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSU2</accession>
    <name>A0A010ZSU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849088.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060578_0_0_11"/>
    <dbReference type="OrthoDB" id="2029990at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28972" checksum="DF1AA32850A3423A" modified="2014-06-11" version="1">MAQQSRYKSVDMNPILLPSRLWSRSLPADAWEAPESWGERRAPVRADHFAKQAAGVCELYSVCLARATPIPAGHGTIALRAVEPDTEGFQPGYSEPYPRTSDIATARLDPALLDLPPETRPSAYLNWLQPVLLGLAATRGVSAAGFHEAYDATLAEGCLMSWEGPGRSSPDRRHRATPHYAIDAQGDAWLRVVIRSRDGTPVAEGGPWESDLRPYRWRRHARTLTWPTPAEVSIEAFLTTTADAWGVEQRHTLTVHPHGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT13</accession>
    <name>A0A010ZT13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851272.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2906"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="23319" checksum="7B50F0A3B878AAF0" modified="2014-06-11" version="1">MTIRVLVADDQAMVRSGLRLILEDQADIRVVAEAADGAEAVARARELRPDVCLVDIRMPRLDGLEVTRALAGPDVADPLRVVVVTTFDTDEYVYGALRSGAVGFLLKDAGPALLVEAVRAAHAGDALVSPSVTVRLLRTVRERAPARAPARPLSERELEVVREVARGRTNREIAARLFISLSTVKSHVSGIQTKLGLRNRVEVAAWAWEHHKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT96</accession>
    <name>A0A010ZT96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate starvation-inducible protein PhoH, predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1484"/>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="116"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="37495" checksum="A5D9140F38CEA6C2" modified="2014-06-11" version="1">MAEIKAPTTAQTRIVVPDAHAMVSLLGSGDAILTLIERSVAADVHVRGNEITLTGTPADNAFAERLFAELLTLVERGEVLTSDAVSRTIAMLKSNSDERPAEVLTLNIISRRGRTIRPKTLNQKRYVDAIDEHTIIFGIGPAGTGKTYLAMAKAVQSLQAKQVNRIILTRPAVEAGERLGFLPGTLHEKIDPYLRPLYDALHDMVDPESIPRLMQAGTIEVAPLAYMRGRTLNDAFIILDEAQNTTAEQMKMFLTRLGFGSKIVVTGDVTQVDLPGGATSGLRVVREILDGVEDVHFAELSSSDVVRHRLVGDIVDAYARYDSDHAPAPRDGGGRRAAGGRSARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTI3</accession>
    <name>A0A010ZTI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851522.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239590_0_0_11"/>
    <dbReference type="OrthoDB" id="1309050at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="22782" checksum="8480D381E0EBD26B" modified="2014-06-11" version="1">MRDLLNHAHGTQLTSAEYRADFGDRFWNAGPDGFWKIERRQTFQEPRDESWRAFNTGDWPTALRLIEEQRPDLEAEGRRLAEENIDAFRVRVVELPLTPYLAWELHLLRLVAETADQVRVIGPETAQPFEPLPELVLLGADVTYEVLYDDEGIAAGAARYIDRELTAACRQSLRQMFATGEDIQTFFEREVAPLPPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTP9</accession>
    <name>A0A010ZTP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3174"/>
    <dbReference type="HOGENOM" id="CLU_087298_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="19414" checksum="4B354D83E1643214" modified="2014-06-11" version="1">MTEAPGGLRLVQDLLNTAGMPVASLPDLLDETSTAQRWLDGTLRAWARQTGRTTPSISLTEKDLAALRTLRGRVRGWVTGESENDGSLAMAADVSVRDGDLVYGPRGRGAAAITSLVALEALLASRTGELGRLKTCQNPACGAAFYDRSRSGTRVWHDMKTCGNTLNLRASRARRRQSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTU7</accession>
    <name>A0A010ZTU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849611.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1691"/>
    <dbReference type="HOGENOM" id="CLU_083329_0_0_11"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="30314" checksum="23599973E29CBC69" modified="2014-06-11" version="1">MSTLETRTLAAPGVDLVYDVRGPLPPADGRPVLLMIGQPMSAEGFGSLAQHFADRTVVTYDPRGLGRSVRSDGRLDNTPQQQAADLHLLIETLGAGPVEVFGSSGGAVTGLELVSRFPGDVVTLVAHEPPINAVLPDAAAVERARAAFNEAYETRGSGAGMAAFIVMTSWQGEFTDEYFTQPAPDPAAFGMPDVDDGARDDPLLSKNSWAVSDYRPDAGLLAAAPTRIVIAVGEESADTYTARTARATAALLGQEAVVFPSHHGGFLGGEHGYAGKPEEFAARLREVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTV7</accession>
    <name>A0A010ZTV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849631.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1701"/>
    <dbReference type="HOGENOM" id="CLU_047832_0_0_11"/>
    <dbReference type="OrthoDB" id="1661570at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="437" mass="46360" checksum="7CFF1CDA4B6F831A" modified="2014-06-11" version="1">MSRILGIELRRSAAFGAALLIAVAGSIVLQATSGRWSSGWMALVMVQREYLIVVVPLTMAAGAWQSYREHRANVAELFATVPRPRPLQVVPVLIATGLAALVAYLVALAAAVPRIIDTASYLPAAAFVVVAVGVLTMVVAFWLGLGLGRLRPALATAPAVAVAGFALLGFGPQLFSDEAPATAFFPGSGMGTFSAYDTISGRISATQTVWLVALAAAAFVLFAVRHRRFAVAALVPLVVGATLTAFAMPTDDAYDREKLDPVAQQLVCTEDAGPRVCVSRANESLLPEVTPKARHVLKLLASTPIVEAHEDTSTFFPMTKPAERPDTVLMNVQVDRHGHLAFPGRLELQMLTGVFGGPVRCGDSRSYTAGTVAAFWLLGREPATGLDGMEFEDPESVQLYRDLRALPKAEADARVAAVYPAAEKCRDTLPILTGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU63</accession>
    <name>A0A010ZU63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851892.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3343"/>
    <dbReference type="HOGENOM" id="CLU_027853_1_0_11"/>
    <dbReference type="OrthoDB" id="919913at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="353" mass="39099" checksum="9E9634A8EAA3A262" modified="2014-06-11" version="1">MSEFLWYVPNQVRAGHRGDDVVEDHNGLPALTQQALAIEEHGWGGALLGAGWNRPDTFTVATALAARTTTFQPLIAARPGYWHPAHFAAAVTTLDQLSAGRVLINVVSGQDNLAAYGDSEGDQAQRYARTEEFLRLVRQLWTREHVTFRGEHFHVTDSTIAQRPVVRPGRRHPRLYFGGASAAAEKVAATEADVQLFWGEPLDDVRERIERLKRLSDALGREHAPLEFGLRVTTLVRDTTEQAWIDAQARVAKMAEGTIARDADWRTAVGQQRLLGLAERGDVLDDNLYTAPGRFGAAGAATTWLVGSAQDVATSLRRYRELGITHFLLSDTPYLPEIKRQGDQLLPLLREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV66</accession>
    <name>A0A010ZV66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CsbD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3750"/>
    <dbReference type="HOGENOM" id="CLU_135567_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="57" mass="5967" checksum="316BAAA2613ED405" modified="2014-06-11" version="1">MSAEDKLSNKTEELGGKVKEGAGKATDDKDLEAEGKGDQAGANLKQAGEKIKDVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV85</accession>
    <name>A0A010ZV85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily protein, subfamily IA, variant 3 with third motif having DD or ED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852524.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="22618" checksum="9AB0455B809A4AD1" modified="2014-06-11" version="1">MDGAVLFDFDGVVVDTESAVVAAWRADCAALGVPFDRAAFVAAVGVPSLRPDRIRAVLGPATGDPAVAAARIRARLRQLSGDLPVLPGVHALLTEIAAAGVPAAVVSGATREWVHGHLDRVGLRDAFDLVVCRDDVRAGKPAPDLYLAALAALDVPAGSAVAIEDTATGIAAARAAGVRCVAVPGPVTVDHDFSGAETVLTSLAGVRLTDLLPGRSQRSAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVB9</accession>
    <name>A0A010ZVB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852573.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3808"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="23161" checksum="DAAFA561A15E6CF2" modified="2014-06-11" version="1">MSRSALVTGGASGLGAASAARLRADGLTVTTLDLRGADVTADVTDEDALRRVAGEIGPVDVLVNSAGVIGPNKPLLDTTADEWRRVFDVNVLGTVNTLRVFVPGMRERGWGRVVNFASMAGKDGNPNLSIYSATKAAVIGLTKSAGKELATSGVLVNVVAPAVIATPMNDDTAPEVLDHIAGLIPMKRVGRPEEVAELVAFLASDRVSFSTGAVYDISGGRATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVH2</accession>
    <name>A0A010ZVH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458093" evidence="2">
        <location>
            <begin position="24"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="94"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="411"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="52837" checksum="CDB0667171AE798E" modified="2014-06-11" version="1">MKKLMIAALVALAAVAGCAPPGARPEPRAAPPAPSAPPAIRWGACPAPAAGVPTSPALTCGTIRVPLDHRRPDGPRITLAVSRLAAGDPAKRRGALLLNPGGPGTEGLHLPATFAQLTSPRVRAAYDLIGFDPRGVGRSTPVTCGLTTAEMVPTSPYPAPDGSIDANIAFARSAAARCRARSGALLPYLTTANTARDLDLIRRALGEERVSYWGGSYGSYLGAVYASLFAGRTDRMVLDSAVDPERIWYDEFRQQSAGMAARFPDAARAAGLSVAEATALYQGVAAALDRAPARVPGSPVVFSGDVFRYLTFSLLYQDAALGPLAQAWRAGRHLAAGVASTEETALLAQILAKITPSATTSPGVPADNAIASAYAVACGDVRWPTTLDTYRRAVARDRAAYPLSAGFPANLWPCAFWPTPPIEAPVRIADHGPRILVLQNERDPATPLESARGMRRALGERSRLVTVAAGGHGVYGVRGPDACENVVADAYLLDGSWPTKDVRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVL9</accession>
    <name>A0A010ZVL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3905"/>
    <dbReference type="HOGENOM" id="CLU_028880_4_1_11"/>
    <dbReference type="OrthoDB" id="1899997at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="32856" checksum="DE1661F1121F4ABE" modified="2014-06-11" version="1">MTRFSRPEVLVPGVALGATILLFLALPLRTGQLLTPFDAYNALQVLARLGPLILALGLTMIAGEFDLSVVGTYAFGGMLAVTYGQGHWAVGLVLALAAGLVVGVLQGVVIARLRISSMPVTLATYITLLGATSSLSGGLSKTFDDAGVTLWVDRPVLQVFSPRSLLVLVVFLVLAAVLAGSRWGREVRAIGGDRRASRVSGVRDDRLLVGLFATSGLLAAGGGALLNFSLGSANPDPGVQPLILAAVAALLGGVSLAGGRGSVLGLLAGALTIAFLAQIVTVAALPTYVSQLFYALLLAGVVAVDAPGLRRGAVRLRKAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVP9</accession>
    <name>A0A010ZVP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850539.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988911_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13606" checksum="994CF15BCE6C579B" modified="2014-06-11" version="1">MEPAEIGAILGAVLSGAGGEAGKQAWVSLTQLLRRRRIAVELQEPVGFPELDARRRQEIVSELGFSVAEMADRDTEFRDEIEAWVADWRSLSRTATSESTNIVSGGVQHGTVVQAHRIDGGVHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVR8</accession>
    <name>A0A010ZVR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570054.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098191_1_0_11"/>
    <dbReference type="OrthoDB" id="1975541at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="19757" checksum="45696FE0831B409A" modified="2014-06-11" version="1">MDWPVVIVVALVFVLLYVWWLARRIARLTARTAAALDALEEQLGRRAKAAATLPGASDVATAALTSGTPDTDGRQGAENDLVRELRQLGTAALDAPGLLAENRRLVVARQVYNDAVRDTRALRTARVPRIFWLARRQPLPQYFDVDELDLDALESDRREREAVRRAAAEDVGRATSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVY1</accession>
    <name>A0A010ZVY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852797.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3998"/>
    <dbReference type="HOGENOM" id="CLU_027853_7_1_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="36851" checksum="872BC9168DA6BE4C" modified="2014-06-11" version="1">MKLALYLPNFRDHVTLPELEDLTALAEDLDFDSVWTLDRIVVPEASDRAELQFPFGMMTEFPKGMPVVSRGKWFQGMTLIPWLAAKTTRLRIGMSIIDTPYRAPAVLAAELATQDHLAGGRLNVGVGSGWMPEEFAAASVPHLFARRHGHVRETIEIMQGIWSNELFEYHGEFADFPLSGFGHKPIQQPGPPIYFSGLKDPRRSAKRIAKYGLQGWIGIQDTPEEIARWRGEIERELGELGRGFPDGFDVCSMIWFVITDEPMDQSPAGKGTNLLAGTAQQIEDMLKRYRDAGLTMPLLWPPFRDVPTAKTLDDLKRLRHEILPKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW36</accession>
    <name>A0A010ZW36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4055"/>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_11"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="31042" checksum="9CC2A0DD65A5B187" modified="2014-06-11" version="1">MTVTVATIGVHVLDTHVLGIQSIPEGSEGQLVESIRISPAGTAGGTAVVLSRLGVTVRSQGAVGTDPLGDALLGALSREGVDVSGIVRTDAAQTSSSVLPVRPNGDRPAWHCIGANGVFTLDHVDRAALEGAAHLHLGGPEFLGGDAAGELLAHARGLGLSTSIDLLAPGDPGMLEWIAAALPHTDYFLPNDEQVLGFTGADDLVAGSRALLGAGAGCVATTRGKQGALVVTPDEVIEVPAFRIDVVDTTGCGDAFSAGFVLGRAQGRSLADAARLGCAAAAQVAQGVGTDAGSYDLASVEAFAASTPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW45</accession>
    <name>A0A010ZW45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852935.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4065"/>
    <dbReference type="HOGENOM" id="CLU_065329_0_0_11"/>
    <dbReference type="OrthoDB" id="1422865at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="29739" checksum="EE3FBE382FB8ECC8" modified="2014-06-11" version="1">MTSDETGKVSFDHIYSRPDPRPFFRTLREFEYGIPGVAAPRFARLFAEYRAARDVATPRVLDLGCSYGVNAALLRCDVTLAELYDRYTAVGGTRAALLAADRALVRSRPRPERAWFTGLDPSAPALEYAVAAGFLDDAVHADLEAGEPEEAQRARIAGTDLVISTGCIGYVTEKTLLRIVDAAGDRRPWMAHYCLRMFPYDAIAGHLDDLGYDTAPIGEPVRQRRFATADERSSVLDRLSELGVDPAGRETDGWFYAQLHISRPRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWH3</accession>
    <name>A0A010ZWH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850936.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2650"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_11"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="265"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="40275" checksum="95DF3332360EBE58" modified="2014-06-11" version="1">MRDAVIVEAVRTPSGKGKPGGALSGIHPVDLLSGALTALLERTGIDPTQIDDVIGGCVGQAGEQALNITRNAVLGAGLPESIPATTIDRQCGSSQQAAHFAAQGVISGAYDVVIACGVESMSRVPMGTSTAGQNPFGTGVPKRYPEGLVNQGVSAEIIAGRWKFGREQLDEYSATSHARAAAAIGAGAFDREIIPVGEFTTDETVRASTTAEKLAGLKPSFYHEKLAERFPEIGWHITPGNSSPLTDGASAVLIVSAEKAKELGLKPRARFHSFAVVGDDPLLMLTGPIPATRKILARSGLSIDDLDAYEVNEAFAPVPLAWAQELGADPAKLNPRGGAIALGHALGSSGTRLLTTLVNYLEDTGGRYGLQTMCEGGGMANATIIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWM0</accession>
    <name>A0A010ZWM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2697"/>
    <dbReference type="HOGENOM" id="CLU_031365_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="37934" checksum="2BB58BF937104B41" modified="2014-06-11" version="1">MTFQTVTAPDAGEHEGTVRRRPSRARGTLGVLAVVTVVAATMPFVLPESQQAVAIRVLIFALMATGWNLMSGYGGMFSFGNAAYFGVGAYADVVLLVGFDVSPWIAMLAGAALAAALAVGTGYVAFRYKVRGAYFALATFAIAEMLRLLATDTTWVNGTIGYHVPLLQEESWWKFQFEANAPEYFWIGLALVVVAFLAVFFYLRSKAGRYAVAIRDDEDAAAALGIPVMRYKLTTMALAAAITAVAGAFYAQYYMFVDPDIVLGQAQSIQAIVPAVVGGVGTLWGPVIGAVIVGPLSTVTATLLREPPEALSFLAGRGGLDVVLYAVLVIVIVLALPKGLYGTIRQLVIDRWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX38</accession>
    <name>A0A010ZX38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851218.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_11"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="450" mass="49640" checksum="6D8B36F2E04FB430" modified="2014-06-11" version="1">MGTDRRYVSGLGEWYRAGRSWVDEHRGRSGLVAGVLIGVLLAATTVYAVPRLIDSTWEDGELVLLSGQDDSVGDQRQQLIDEWNALHPDHRVRIEEIRSIADAERGEMLARAGGDGPAVDVLNLDVAWLPEFAEAGLLRRIADDTVDRAAFLAGPLSTCEYDDRVWALPFNTDAALLYRRKDYLPSEPPSWTSFTGSLDMLFKGNALQKAGPQAGLVTQLGDYEGLTVNALEMVWAAGGEIVDEDGEVRVDSRAAQAGLNYLVDGLKTDPKRIFPGSVGYSEADSTSAFLQDQAMYLRNWPVAYRALEEQDRESGRAEKDSRYAVSALPWPSVLGGQNLAVAGRSEHPRAARALIGFLTDSRSQQILFERGGFAATRKVVYQDAEVRKNYRYAAALLESLERARPRPRSPHYALFSEVLRGALHEGLVTGDWPPPDLADDLRAALRGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXC7</accession>
    <name>A0A010ZXC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851349.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132654_0_0_11"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="21330" checksum="41FF3A2F9B4A1779" modified="2014-06-11" version="1">MTLVWVTGNSGAGKSAVCELLKHRGYEAIDADWEGYNHWVDRISGERVSDPPDPVPPGWLNRFGWTIDRAEVLALATRAADRTVFLCGSVENEDEVRDLFDVLICLVVDTPTLRSRLANRTTNSFGAHPEELAAALRDNDTAESTYRPLGATIVDSTRPLAVVTDEVLAASGGSRGGRGLGVDDPGQRRPEQGQEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY82</accession>
    <name>A0A010ZY82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851789.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640724_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="319"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="41358" checksum="EC3A25D7802F4F83" modified="2014-06-11" version="1">MTLRSLALLSRGAAELKRGNIAGADRDLRDALTLARRCDLGRAAISAASHLAACHAARGQLRQAARCATETLAHADRLGLAQLVDLGWSRLALAEAYFERNRIEDAERWAAAAVGGSRGDRLIQLWGTILQARIRTATGRPGEAHRMIQAASREIVVSDLPPVALRGALSLVEGELRLACGDLLGAHEFVRTCRDAGALPAAAAVLEASVLLAEGRPALAAAVVEPHVAAHDEFNSRTCRAWAGLVSALAGQSLGRHDQTMRGLEIALRLGEEEDLRRGFAVGGFRLRALIESVAPTMPVYPSVRAVLTATLDAATFPAGSTIPPLTDRELTVLRYLQSTLSHVEIAALLHISVNTVKTHVKNVYSKLGANRRKDAIQRGRELRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYL6</accession>
    <name>A0A010ZYL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851964.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2507099_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="85" mass="9603" checksum="A4CC87DE9EDA8137" modified="2014-06-11" version="1">MTYEDPNYGEAEIVVSLQQFARMAAGEDLAAERVRVTSVESERRRRRREAAGLTNDQMCEEAAPRLPGGRRDLRQPDAIRTRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYN3</accession>
    <name>A0A010ZYN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3355694_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="36" mass="4319" checksum="A323817E77A4C51D" modified="2014-06-11" version="1">MKPRRTWKKSTVQCLDARPEISAYSGDDQLWPKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYV5</accession>
    <name>A0A010ZYV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852160.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3530"/>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_11"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="12892" checksum="91C89CE5E3CE0224" modified="2014-06-11" version="1">MATSPVTAPTRPDATSDAALCCAPITGTPLSASEADQLAALLKAIAEPTRLRLLSLVAAHEGGEACVCDLTDPVGLSQPTVSHHLKVLVDAGLLTREKRGVWAYYRLVPGRLSQISQALSVACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ18</accession>
    <name>A0A010ZZ18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1616269_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="17182" checksum="1878F5321CF16E1A" modified="2014-06-11" version="1">MSSGTSMFWPDEDPLQPTSEEYGADLPVTTVMRPCVVLGENEPITVAWNRMRAHGEVALVVDGAAHVVGLLGLREVSERWPVRPPLSAEPTAGDALRGVRTCRITATTSVRDAVRTLITDQRATAPVVTADGRGLGVVTALDLLTALTGRSSPAGRSSAQPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZH6</accession>
    <name>A0A010ZZH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase (Class 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852546.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3791"/>
    <dbReference type="HOGENOM" id="CLU_029537_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458446" evidence="1">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="32086" checksum="371C6DA190D441C9" modified="2014-06-11" version="1">MKLPRLGLLVAGLLTAAVITPAPAAAATTETPVGDLGTAVTNFLTSPDRVAGANDWSCRPSAAHPEPVVLVHATFVNQGANWVALAPTLANAGYCVYAFNYGMNPVLSAGRVGGLTDIAGSARVMRAFVDRVLRATGAAKVDVVGHSQGGLMPHYYLERLGGAPKVRTFVALAPSNHGTDLNGLIGAARSLNLLGFANRALTSFNLAGLVQQETGSAFQRGLFADGDTVPGPRYAVITSNRDTVVTPYTNAFLTGPNVTNVLLQDQCPDDRVGHVGLFLDSPAIQNVVNQLGDGAPDFRPVCRGYGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZQ1</accession>
    <name>A0A010ZZQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3871"/>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="414" mass="43439" checksum="A1EA5515098A7725" modified="2014-06-11" version="1">MIAGDKPLRGRIVLDLTTALAGPYATLLLAGLGATVIKIENPATGGDSSRNNAPYLGADGLRMDRGSAEDMSVSLIGRARNKQSITLNLKQPAAREVFLDLVRHADVVVENYAAGTADRLGIGYSACREVNASIIYAAISGFGAQGAPGSGKAMDSIIQALSGVMYTSGEPDSDPVRVGLPIADLLAPLFAVIGVLSAIVEVEQSGVGQQVDVSMLGALTSLLSIEPFDAFELLGAPTRTGRTLPRLAPFGMFPAKDGWVALCAPTDTFAAGVFRAMGTPELAEDPRFRTRDQRVGNSTELHARLDEWTGTRTRDEIVAVLAEHGVPAAPVRAPAEAIHDGLVRQRGEVVDLEHPAYGPTGTVSGPGLPIRFSESAAGFDLPAPRLGEHTDDILRELLGYDGDRITGLRESGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB30</accession>
    <name>A0A011AB30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847733.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.232"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="412"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="517" mass="57221" checksum="0B8E520D7A5613AA" modified="2014-06-11" version="1">MGLPEVPERTLRAAYDRALAEIPDDLAQIGRAARYTVAESHDRSLRIAAGLRSLGLERQQPVALLTDNSLDAVHAWTGVSLGNLIEVPINSAYKGSFLTHVLNDSGAEVLVVDDGYVERVERIADDLTALRTLVVRGDQVPSARFDVRPFDELLSHEPAAPTKQTADDLMAYMYTSGTTGPSKGVLISHAHAYTYASREDQARPVRDDRILVTLPLFHLAGQWYGVYQALIHRAACVLEPSFSVSAFWPTVREHGITVTVMLGAMAELLQQAEHRPDDADNPLELAIMAPLASDIDGFRTRFGVELAAVYGMSEIGAVLNGPPDTLVGGECGFPRDEFELKLVDGELHVRPSDPLLVMRGYHNLPDKTAETLVDGWVHTGDAFRTDADGRYYFSDRMKDALRRRGENISSFEVERVINEHPDVSESAVVAVPSDLTEDEIKAVVVPREGRTIDPAELTRFLVDRMPYFMVPRYLAFASELPKTPTQKVHKHRLRDAGVGDRVWDREAAGIVLRRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB55</accession>
    <name>A0A011AB55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847758.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.254"/>
    <dbReference type="HOGENOM" id="CLU_025443_4_0_11"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="47"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="33490" checksum="367E2717B9CA53A5" modified="2014-06-11" version="1">MKWGTRLSLGVVGAGAATLLYASAYERRHWTLRRFDVPVLAQDAEPLRVLHISDLHMLAGQHSKQTWVRSLEALDPDFVALTGDNLSSPDAVPAVLDALGPLLRRPGAFVFGSNDYYGPVPKNPFKYFLRNHKRVHGPSLPWTDLRDALAEAGWADLTNAKATVVAGGQLLELGGVDDPHLKLDDYPAIAGSLDPGADLHLGLVHAPEPRVLDQFAADGYDLVLAGHTHGGQLRVPGYGALVTNCGIERDLARGAHRWNGDTWIHVSAGMGTSPYAPIRFACPPEVSLLTLVPRPEHGARDTRAQEAAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABN0</accession>
    <name>A0A011ABN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848071.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.450"/>
    <dbReference type="HOGENOM" id="CLU_046420_0_1_11"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05018">
        <property type="entry name" value="CoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="22414" checksum="819E8D1176395C56" modified="2014-06-11" version="1">MKVNGKATLNAPVERVYAALNDPAVLVRTIPGCQQLEQVGDDAYRMTVTAGVASIKGSYVGDVRLTDQQEPSSFVLRAKGAGAPGTVSADVLVTLEHGAEGTTLLSYAADAVVGGAVGGVGQRVLSGVAKKTAGEFFAAVDSLLNAPAEVLAAAPASSAATEAPAKGALVGGAAVAPAAGEPRVFTAPAKAPGGGGADLLAGGFLPGAIFGAGIALLGVVVGGLIGRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC37</accession>
    <name>A0A011AC37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370182_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="20600" checksum="F2BB6ABBC4407D39" modified="2014-06-11" version="1">MEQTNSVLVPAPERDPAQNRIGPRPGSGRRTIVALAGVAVAMLVVAMSTILLAGLAFWRSSEPASAQPVAKSYSGNLAADLRIAPVVEATGTGCSDGGTPGRFAGCFTLGEGGMVVTVVESADTAVQDGKWVLRLRFSSADTVALRALTTQSQRIALVLDGTVLTAPTVKKPITGGEVQIAGDFTKKDVDAMFAELTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACV3</accession>
    <name>A0A011ACV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.916"/>
    <dbReference type="HOGENOM" id="CLU_020884_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="99"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="37794" checksum="51297C5BFC3433E8" modified="2014-06-11" version="1">MLDADRLARARRTRLNADRRRRGERVWPESFADRLTSPLPGPREQFQLFRRGRPRVDRTDAVRIPIDRSGFVRATGQDQVVVTWVGHASFVVQIGGLTVLTDPIWSDAMPGVSRRVTPPGVAWSELPPIDAVVISHNHYDHLDAPTIRRLPRDTPVLVPAALGEWFTRRGFTAVTEFDWWESTVLAGVTFDFVPAHHWSRRSLTDTCKSLWGGWVLTEDAGRRIYFAGDTGYGNWFAEIGERYPGIDLAMLPIGAYHPRWFMQPVHMDPEEAVRACGDLGATRMATMHWGTFVLTGEPLTEPREKAQQAWAAAERPREHLWDLAVGESRELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADJ3</accession>
    <name>A0A011ADJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848907.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1166"/>
    <dbReference type="HOGENOM" id="CLU_996688_0_0_11"/>
    <dbReference type="OrthoDB" id="2023468at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27464" checksum="962A3D7B6F3DF58F" modified="2014-06-11" version="1">MTAMAEQVSTFERNAPAAPSLGRLTLVELRKMSDTRAGRWLLASIALVVVGLVTVRVFAGSAETRDAEEFLAFATGGVSLLLPVLGILSVTSEWGQKTVLTTFALVPRRSRVITAKLLAAVAITVMSVAVTIVVALAGNLAAELLDRGGDWNLGLDAILYAFLFQLLNMLLGIAFGALLLASGLAIVLYFIIPTVWSVIGGTVAFLKDAAGWLDLSTTTAPLLTASMGGEDWARLAVSTTLWVLLPLAAGLIRVLRTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE90</accession>
    <name>A0A011AE90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569859.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1397"/>
    <dbReference type="HOGENOM" id="CLU_050357_1_0_11"/>
    <dbReference type="OrthoDB" id="1095432at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29511" checksum="01938CDDA4C646DD" modified="2014-06-11" version="1">MPRCAVTARERGDQLFATAAPGERWLLVEHPGPWPRRAFEASPELTRVAERAVASGFRAVLIRRPGRSPAREVRSYAVVDARPGREGISWGTFTAEAELLDVPLALDPSFSDEPVHLVCAHGRHDTCCAVEGRPVAAALADAYPGRTWECSHVGGDRFSANLVLLPHGLYYGRLDPGAALEVAAAYRAGRVVPSLLRGRSVFAPAVQAAQHYARLESGNDGVDAFGPLGIEALDASTTRVRLEGATVTVRMGWSEPAVLTCAAGGPEVARVFSRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGM8</accession>
    <name>A0A011AGM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850364.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050520_0_0_11"/>
    <dbReference type="OrthoDB" id="1706322at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="35057" checksum="AF3C3C84BC3DE15E" modified="2014-06-11" version="1">MTDVGRQELDRAVHQGSLSTEAGPLVARIVEVLPVVPERTALLEFLGHVAARASSFQADPLTVDYVRRDDPELPFYEVVWEPDHAPDHVVVSRLGSACAARAGVVLPALVPWLDAADPHERRAALYATASWAALAGGGVPDQALHHLWTGARDHGAEARVHCVLGLAGAGADTAELLTDPSRVVRACAALSPAVATDPRTLPVLTAALADPADCDSWIDGHPAPPHAGDEMSALLVEAATRCTDDFAELLPIALSVGRASPACSPDRTWGRLLHAAFPQPPAEPLRGPQRAYLQVLAANDYFWQISDVERDAVLGEVGLPTDREALRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGQ7</accession>
    <name>A0A011AGQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850387.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2254"/>
    <dbReference type="HOGENOM" id="CLU_092792_1_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="24148" checksum="3383993B4CED01F8" modified="2014-06-11" version="1">MTFQRARSEEQREARRRAILDTAAAMLDEMPVAELSLNELSRRVGLAKSNVLRYFESREAVLLELLDRYLETWLVELADELAAGVDPRAGVEERSAQLAGVLSRSLAPRVRMCELFGAQGSVLERNVSLEVVVRYKRASLQRLTTMTELASLYVPELGGSAQLFCLNTMVVAGALSAYASPLPAIVAAYEAEPELAVIDLDVREGLRLAITMALLGAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGT7</accession>
    <name>A0A011AGT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850428.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2279"/>
    <dbReference type="HOGENOM" id="CLU_084257_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="46"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="27030" checksum="C34804BF1DE555DB" modified="2014-06-11" version="1">MQPGVAVNTLVEFCARRDVAELTPDALGPVDVVILFGGSILAGGDVFARAIADRVAGHFVIVGGQGHSTDALRDTCRNVLGWDDVDGRSEAALFDRYLRERHGVEADRLETASTNCGTNVRNALELLAAERVPHRRIVIIQDASMQLRMHACFRLLAPDLEVVNFAAHQARVDEHLRIVNPPLGMWSPERYLTLLMGEVPRLTDDEHGYGPAGRGFIAHVDVPAPVREAHAALLAAGVGESRAADPRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHG4</accession>
    <name>A0A011AHG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850801.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2539"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458709" evidence="1">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="44"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="34493" checksum="576509C5BF9AC122" modified="2014-06-11" version="1">MIRRVSAAIAAGLLVAAGLAGCGGDSGSGSGNDDGKITMGFAQVGAESGWRTANTKSIQESAKAAGIELKFSDAQQKQENQIKAIRSYIAQKVDVIAFSPVIESGWDQVLKEAKDAEIPVILTDRAVDSKDTSLYETFIGSDFVLEGKKAGEWLVEDSKAAKGPVNVIQLEGTTGAAPANDRKSGFADAIKADPKIKVVASQDGDFTRAKGKEVMEALLKAHPETNVLYAHNDDMGLGAIEAIEAAGKKPGVDIKIVTVDAVKDGMTALSEGKINFIVECSPLLGPQLMDLAKQVVDGKKVEKRILTEETTFTQEQAKAALPERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI64</accession>
    <name>A0A011AI64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862228.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2768"/>
    <dbReference type="HOGENOM" id="CLU_036110_0_0_11"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="31454" checksum="CE4B18AB07AE6510" modified="2014-06-11" version="1">MDVVAPGARLERVWTGGSWGEGPVWLPGTQSLRWSEIHGNRIYEYDSRSGETHVHRQDVEFTNGRTLDLAGRVVQCSHGRRCVEVEVDGEPTTLVDHWGEHRLNSPNDIVVASDGAIWFTDPPYGITQPDEGHPGSMEYGGCWVFRYEPGLLRPAITDMQRPNGLAFSPDESLLYVSDTVDTARGLIRVYDVTDATVSNGRDFATVLPGCSDGFRVDVTGRIWTSSLDAVQVLSPDGELVARIPVPEKISNLCFGGPDGTDLYITASTSLYRIRTLTTGATWARTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIF8</accession>
    <name>A0A011AIF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="350"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="489" mass="53125" checksum="CA25CD78CEDBBAC1" modified="2014-06-11" version="1">MRVGDSRRVAAVVLAVIGVLFGIYLLGNEWVRVSVVLVADGAGAVLVLRGVLRHRPPGPLPWLFLAGAQSLAVIADCLFYGGYLFDRAWDFPGPPDLFFLARYPLWFAVALLWVHRSTRHDAFRWRTDVTLVDVAIIVVASALLSWIFVISPLIRDSPDVALLVLYAAYPVGDLILLAVGMRIWFGGGQRSVSLGLLGGFATCWLAADTAYLLSLANGTYRFLGWTEPLWIAAAIALAAAATHPSMVSVGRPSADAPRSGTGRRLVLLGGVSLLAPAAQFVQYLRDGDLHVPVVTATCAVLFVLVMFRMGVLLREQRRIAITDTLTGLRTRRFFEENLALEAERAARFGSPMGVLLVDVDHFKTVNDRYGHKAGDTVLREVARRLRECARAGDVVARYGGEEFALLVAPTDRAGAARLGERLRDAVGGESFRLDDRTELLVTASIGVALLPDHAATPDELTVRADQCLYRAKNAGRNRVVVAGELPVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK11</accession>
    <name>A0A011AK11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3429"/>
    <dbReference type="HOGENOM" id="CLU_380718_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017511">
        <property type="entry name" value="PQQ_mDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303:SF4">
        <property type="entry name" value="PTHR32303:SF4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459507" evidence="2">
        <location>
            <begin position="33"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="727" mass="76750" checksum="8948F7E92EC6BEB5" modified="2014-06-11" version="1">MESTDTAAHRLGRRAFLAGAAASATAATVPIAAPARGAETDAVAVPRQPAGLGATGKDSPKVGGDLGNQNHSSLKQITRRNVSTLGGAWHVNLEAGSTASAQQSTVVVENGVLYVQTTQQNVFAIDGRSGKTKWTTNVGTKTTNMRGVALGEGLVFSTSGENNVYALDQATGAVKWKRALITADEGGGDTGGCDPQNGQCGGVTGTLAGAVVYWDGLIYVGMQGSTGGARGRAYALKAATGEVAWTFWGAPGEGEFGNDSWEGDSWKTGGAVPWIHPAIDPALGLVYWTFSGPYPRTDGSSRAGDNLFANSIVAIDAKTGKRRWHFQSVHHDIWDMDNVMAPVLVDLTIGGRKRSVVVYGSKVAMYYVLDRATGKPIHGMTEREVPQDARQKTSPTQPFPGGKPFLTQAPRADKPTRPVPHYDWGGLYTPHWDRPTIIFPGAGGGADWSHLSFNPYTGWIYVGYGLINSGFSNARDGRVNTSRPLGEYFGGGIAAVDPRTNTPVWTKDGDWSLAHGNGILTTAGRVMFQGGPDGVLHAMNDETGESLWSFQCGAGVHTSPVAYEIDGEQYLAVFAGGNGLPYPDIPKGDHLWAFKLGGTVAPAAAPTPPSKRNQIRAAAVAGSAVDNTVTLGRIWDPATGKPGTTENTVAQNAVSPQHLRIPAGTTVTFVNPADNANPHSADSFFDNEFNTGIVMPGQSKAHKFDKPGEYFYNDAFFAQNTGKVVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKD9</accession>
    <name>A0A011AKD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301122_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="11200" checksum="28320B51B51CC433" modified="2014-06-11" version="1">MSRRRGGEVNALAERLARASSIEVSRAWEQMDDDERSRWIAAWQPTALSLRARKALPLSDREVTTIAQTHRRIESSGSEPPRAGMTEAAQMVIDLRIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKI5</accession>
    <name>A0A011AKI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase,'ATPase, histidine kinase/DNA gyrase B/HSP90-like',GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3637"/>
    <dbReference type="HOGENOM" id="CLU_034370_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="221"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="579" mass="61546" checksum="A058370A3DCE6645" modified="2014-06-11" version="1">MAREAEPMLHFPDLPRLELDQLLAQLIERATEVMGAQGRLRGLLRANQLIVTDLALPAVLRHVVEAARELLDARYAALGVLTPAGGLVEFVHVGMPADTVTTIGDLPTGKGLLGALIDDPRPIRLDRLDDDVRSSGFPPGHPPMENFLGVPIRIRDEVFGNLYLTDSVHGRFSAEDEELARALAATAAVAIDNARHFESTRRRGEWLDASAAVTQRLLAPGTRDALRMIAENTRRLSDADLVALFLPEDQSRSTLRVEVAVGGTADQVTGRNVAADGSLCGHVFTTGQPLRFRDPADHPDLPRSAIADDVSAGPMLFVPLTGSGRTNGVLAVIRHPGRPAFSSEDLDMAAGFAAQASVGLELADARADQERMGMVEERRRIAEGLHDHVIQRLFAAGLTLHGAAARIPDRALSRELVGVVEQLDDTISQIRSSIFALEQTGPRTGGLRAEILDLVNDAAGALGFSPGLRFSGPIDALLGGPGTSLGADLLAVLREALSNAARHAHATRVEVGITAKDAQAGRRAEITLEVRDDGIGTGPTDDRSGLADLRARAERHGGTFLVAPALPNGTCLSWTAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKZ2</accession>
    <name>A0A011AKZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3795"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="27455" checksum="E0EE3B838AF2350D" modified="2014-06-11" version="1">MVARPDAFALPPRGRAERLGVAVTSELVEMIVTGEVAEGDLLPPEAPLSEHFGVSRTVIRESIKRLEEKGLVVVAQGRGTQVNRSGSWNMLDPIILSALIDNDESLGILDELTVVRGHLESAMAGAVAARNTPDELERIRQVHDTMRGMQQESDASRQEDVVFHLTIMEISRNRLAENIAKRLYRRALESTRYQGADYAGAFESTISEHGRVVDAIARNDVEGAERAMREHILSSWRRRRLAGPPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALV4</accession>
    <name>A0A011ALV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853003.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4103"/>
    <dbReference type="HOGENOM" id="CLU_101689_0_0_11"/>
    <dbReference type="OrthoDB" id="1629363at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="24956" checksum="CDF61508EA7EE372" modified="2014-06-11" version="1">MRKLIVAVHGADPGPRLSAHTLREALGSVGATALQVNVDDEAVAPALRFGPGAPITALVSVWTHGDPGAVVATVAAAAGDAEPHAYRVSERVRLDPAPVPDGERADVLAQVALLRRPASMTREQYLEYWMVHHTPIAIRTQGTVCYVQNVVEEALTAASPPVAAIVEEHFPMDALTDPHAFYDSRGDEAELRRRTTELLASCARFGADQGLDLVPTSRYRWALQPGSTRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFM1</accession>
    <name>A0A010YFM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator of the LytR/AlgR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.43"/>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27767" checksum="A0CF53F14611015C" modified="2014-06-11" version="1">MGIVKGLRVLAVDDEPLQLDELAYLLRGDQGVAEVVTAGDTTEALRHLRDRGVDVVFLDIRMPGLDGMELARLLGRFASPPAVVFVTAHDDRAVDAFDLGAADYLLKPVRADRLAEAIRRAARARVASAGQQPQPEPVADDVIPVELAGTTRMLPRSSVRWVEAHGDYARLHTSDGNHLVRVPLSLLAERWADAGFVRIHRSYLVALRVIAELRLGSSGYVVVVDGRELPVSRRHTRELKDRLVRAAKTGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGB9</accession>
    <name>A0A010YGB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847788.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486377_0_0_11"/>
    <dbReference type="OrthoDB" id="514956at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="560" mass="58286" checksum="7DBAE6538AB26008" modified="2014-06-11" version="1">MEDYYGYTWEPGSVRVAEHDTYVPEGTAHLQRVTDFTDEVKVAHIRVLWPMIEGLDATKIADLAGNWRTLSTQLTSAKTGLSGAGGRLAPQWTGEASRAFLERVGGSLFSLDQWIEAASTNAATIGRLADDVRTTQPKVRRIYRDWLTESANQRAKRDKDADALTGQDLNDLVGMLSQSKSIADGGFLYRWARDSVPQDEIDRKYTALALPLVKKLAEHFSSAATTGVTLPGKFKGPTTFKSVRPTFPGAPGLPPVRPATPTIPVVAPPAVPVPSVEAPSGALPIPPTPPALPGARPPAVPALVARPPVAPVLATRPPTAPLRPPIARPASAPALPALPGRTGPRTRSAVPPVSGRRAPAKPAVPALPGRTRTTPSAPRNGSAQRASGRPAVPPMAGPRLGGRSAPLAVSRTEKAPPKAAPPRLPGRVGAPPKPMSTPGSVPSEFHRTPPTAHERVADASSIAPRSPAPPSLGGRRGSMPPLASAPATTSAPELTGRAAPRGIQPPDTRPAVEVRRTGPDLASVPEESFAPAESAPPVIERPTSPAAQPAGPALGRAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGK3</accession>
    <name>A0A010YGK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725645.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046703_0_0_11"/>
    <dbReference type="OrthoDB" id="1220759at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="35102" checksum="D3FA98C1003016F6" modified="2014-06-11" version="1">MAVSWRSAAQDALYGSAGFYVVNRPAAHFRTSVHAAADLFADAIGELLARVDHALERPDPLDLVDVGAGGGELLSALSVPSGMARRLRLTAVERGPRPPGVGYRWGPEIPPVTGLLVANEWLDNVPVDVACRDESGADRLVLVSPSGDESLGDVVSGDDAAWLARWWPLRSPGDRAEIGSARDAAWAAAAGRVRRGLAVAVDYGHVAGARPAGGTLTGYRDGRQVPPVPDGSCDLTAHVAMDSLAPGAVLRRQRDVLRALGVSGGLPPRELASADPARYLRALGSASRAAELLAPDGLGSFYWLLGEHGLGRDLDLGLGVPEAANLADREGRHEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHD6</accession>
    <name>A0A010YHD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860407.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.715"/>
    <dbReference type="HOGENOM" id="CLU_032013_2_1_11"/>
    <dbReference type="OrthoDB" id="228571at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="39128" checksum="8BB468FB0AA9E7E8" modified="2014-06-11" version="1">MTLQPREGRIPGDHYLETTPETAQWGFLPNRASAPVLNVESGATVTIDTLSHEGILEDQGRDPVAYLAGFGVKATEVLEDSRVFAASDLTHDFDDGPHVVTGPIAVSGAEPGDLLRVDVLDLGIRAPYGFISNRHGYGALPGEFPEGTLRREDAHVLDPTSFGSNIHFTDVTENGGVLYGNLRFGEGRGVRFPLRPFLGLMGVARDTDEAVPSVPPGDHGGNMDVNELQAGSTLYLPVQTAGALFYAGDPHYAQGDGEVALTALEAPLRATLRLTVLKDAAARAAVGAIRNPFVETDTHWIPTGMDPDLNEAMRKAVRAAVSFLETHQGVPRATALAYLSAAGDFEVSQVVDAVKGVHCLIRKADFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHJ0</accession>
    <name>A0A010YHJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569710.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060923_0_0_11"/>
    <dbReference type="OrthoDB" id="1574388at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="34950" checksum="745C725FDF46986E" modified="2014-06-11" version="1">MNWETLNWFGVSCWLLAAVLPWAVAAIVGLAAPDLVRRVHPATATWSLTLVALGVATATAIGAGAAAVALLRPLLWEAPLPDGYGLHTPGRVAVVLLVGLPLLAAAAAVVPVAWSAVRDLLAAKDTWGRARPVDGVLIVDDPDPEAYAVPGRPGLVVMHTGLLEVLAPGEQEVVLAHERSHLRRRHYAHVLLVRVTTWLNPLLRPLVASVTEQVERWADEDAAREVGDRTVAARAIAKAALARSAVRSGRSPVVRRTPQPVLRATTGDATARATALMTPPLPAGRPLLALVIVLALALPIHSGWGARAVESLYRSACAQISEQVRPDDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHU2</accession>
    <name>A0A010YHU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250269_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="42" mass="4336" checksum="94FE450BE61094EE" modified="2014-06-11" version="1">MRRGFGILLATIALALFGAVPIATTSIDSGASTPNSTEWGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJK3</accession>
    <name>A0A010YJK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725676.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_11"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24767" checksum="42BD1D64106437CD" modified="2014-06-11" version="1">MTARRVLIWRHGRTEWNAAGRIQGQTDVPLDETGVQQALQAAPYLAAEEPDAIVSSDLQRAFRTAEALAALTGLPISVDPRLRETGFGPWQGLSHAELAERWPAEYAEWKRGETPEVPGIERPAEVVARMRDALADALGAVDGTLVVVCHGGAARRAVQALTGWSDEVAAQLAALGNCRWTELRLSSTRGWRLHAHNVGPLTGAASNDEPSTAADAEPAADDELIKASERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJQ7</accession>
    <name>A0A010YJQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1523"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23295" checksum="EB911E861A986600" modified="2014-06-11" version="1">MRAVRVVLAEDGALIREGIAAALSRFGYDVVASVGDADSLRSATSAFDPDLVVTDVRMPPDETDDGLRAAVTLRSGRPGLAVLVLSQYIELTYAAELLDSPGNAGVGYLLKDRITDVGAFVDAVAQVVAGRTVVDPQVVRQLLRRNRDPLQRLSEREREVLALMAEGRSNAAIARQLRVTDAAIGKHITGIFTKLDLEQAGDDNRRVLAVLTYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK03</accession>
    <name>A0A010YK03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849524.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1630"/>
    <dbReference type="HOGENOM" id="CLU_039329_1_2_11"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="35127" checksum="F5B67ED828849CC6" modified="2014-06-11" version="1">MTHAVDLHAHALVGRAEGLVADEPALARSRVAEARAAGAESSAVNREQIAAIVPALTDPALRLAAMDRAGLDVQVVSPMPIHHYWAGAPLAERYARTVNDGILTHCAAAPDRLLGLGTVPLQHPALAVSELTRAVADGLRGVEVSTYVDGRELSDPSLEPFWARAEELGAIVFVHPWGCTLGERLDLAYLSNTIGNPLETTLALSRLIFSGLLDRRPGLRIVAAHGGGYLPVYSSRADHAWEARRDARTCASRPSEYLRRFWYDSLVYTGEALDRLVAAVGADRVVLGTDHPFDMGVTDPLDRLALASLDADSADAIRGGNATALLGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK99</accession>
    <name>A0A010YK99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138495_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="15047" checksum="71BE4D4C5D133E28" modified="2014-06-11" version="1">MRVGLVVLAVLDGTVGAWQYFFPRSFYDDFPTVSNDPPYNEHLMADVGGLNLAIVTVLVIAAVVLEYRLVMAALAGFGVYCGTHFVYHVTNFEGFGVRDAVAVGTGLGIEFVLTIALLFLGYHLRTRSLRRARSDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL68</accession>
    <name>A0A010YL68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar basal body rod protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850123.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2040"/>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_11"/>
    <dbReference type="OrthoDB" id="1870921at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="2">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14255" checksum="39C6E9F92DFAB855" modified="2014-06-11" version="1">MSLFPAIGISSTGVTVHRKWLDAISDNLANINDVRPTSGEAYRAKQVIAQAVDYGDGKGGVQVGGIVEGPAEGRLVYAPDNVMADAEGYVRMPDIDLADQMGQLLMAQRGYQSNLAVIDRAKDSYTQAIQLGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLB5</accession>
    <name>A0A010YLB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytadhesin P30/P32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2084"/>
    <dbReference type="HOGENOM" id="CLU_068015_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="37180" checksum="BA4C1C720ABE917D" modified="2014-06-11" version="1">MSALAPVGETIAPESSAIASIGATDSAASRPKTLIIERILRDREGLWRDVLAERNLNTVLRRMLVSSVISLALYGLVLGASAGPLQAVSSAVKLPLLFLLTLAICLPTLYLFNLVFGARLSIRQALALVLVAITVTGALTLAFAPISLFFLVTSSDYSFFKLLNVGILMLTGFIGLSLMVDGMRGLNRLSGHEPAPRPEPRTAWDALDANVHGHYAIHGAPGLHPTPGMHPTPGMQAAPGMQAAPGMQAAPGMQATPGMHPAPGTHPAPSTHPVPGTHPAPRVETAPGAFDRPVNTRLLYVWALLFGFVGTQLAWTLRPFIGEPNHPFQLFRDIEGSFYSNVLSTIASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLI6</accession>
    <name>A0A010YLI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRC-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570014.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2151"/>
    <dbReference type="HOGENOM" id="CLU_050193_1_0_11"/>
    <dbReference type="OrthoDB" id="1849143at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="19931" checksum="B099D21E2A20CEF9" modified="2014-06-11" version="1">MLTQEQIPTLMQSTAYDPSGDKIGSIKQVYLDDRTDRPQFATVHTGLFGLKESFVPLDGAELHGDRVVVPVDKAQVKDAPSIDPEGSAGSLTPTQVAELHRHYHLPARPGGTRDAYAADVDSGSGEHGHGQHYESDQGNVRFSGRETRTDRDDTRDERLATGSERHEPGPAGLRRYVATDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLM1</accession>
    <name>A0A010YLM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted/surface protein with fasciclin-like repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850303.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2185"/>
    <dbReference type="HOGENOM" id="CLU_031281_3_1_11"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458811" evidence="2">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="79"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="21400" checksum="8B0DE978FB723ED7" modified="2014-06-11" version="1">MTRVRTRLLGVTTAALLALSMAACSSDDSSDTATTSSDSTSATAMASPSESAMSADAPFGAACSAVPASGSGSFSGMAQDPVATAASNNPVLSTLVTAVKTAGLVDTLNSAKDVTVFAPTNDAFAKIPEADLKKVLADKATLTKILTYHVVGQKITPDQLGTAGPFKSLQGQDVTATGSGEDFTVNGTAKVVCGNVQTANATVYLIDTVLMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLN3</accession>
    <name>A0A010YLN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850319.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2198"/>
    <dbReference type="HOGENOM" id="CLU_090311_0_0_11"/>
    <dbReference type="OrthoDB" id="1772930at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="22905" checksum="25F367A818959611" modified="2014-06-11" version="1">MSAVVFLGPSVDRPTAAGVWDVEFRPPIARGDVDAVLARPEPPAAIGIVDGRFLSAFSISPKEVLRALDAGVAVYGASSMGALRAAECAPYGMIGVGAIYAEYASGRLDADDEVALTYDPDSGRALSEPLVNWRLALAPAVTSGRVDAELAARFLATAKALYFPERTLPAVLARMTGADPTGLAALAHYLKTDAPDAKRDDALALLHRMAADLGQAARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM52</accession>
    <name>A0A010YM52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850541.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2342"/>
    <dbReference type="HOGENOM" id="CLU_046006_17_2_11"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="15507" checksum="D3AFBA4839467029" modified="2014-06-11" version="1">MTINTTTHLNFRGDARAALEFYHSIFGGEIVLATYSDAHSVQDPAEADWITWGQVEAGNGFRVMAYDVQVRRPFERGANSFFVSIRGTSADEVSAFWKGLSEGATIVEDLAPAGWSPLYGMLTDRFGVTWVLDVEAEYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN68</accession>
    <name>A0A010YN68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine/putrescine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2720"/>
    <dbReference type="HOGENOM" id="CLU_026974_8_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457631" evidence="1">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="351" mass="38553" checksum="14B030E6E003CCF2" modified="2014-06-11" version="1">MKTPLRLISVLTVGTLLLTACGVGGESGGDSSDQKLTWASTGGQFQEDEKTALQKPFTAKTGTAFTNVSPAEQAQVRTMVKARKTIWDLANMSWIYAGAYCGELFEKLDDPALDRSKFPAGTTGDCFVPTYRYANIFSYNADFYPGAKPTTIKDFFDVKKFPGKRVVYDYPKAGLFEAALVADGVAPDQVYPLDLDRAFAKIDTIKSSLVFAPSYGAIQQMMVDKQASMVLTVTARTIVSAQSGANLVPVWDFNTTDIGVQVIPKGSPHKKLAQQMLAFITEPEQAKAYAKLTGTAPARPDVDLDSIGYTDEQKKFNAFLPDRGKTVEQDKQWWIENTDALVKRWTSWKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YND9</accession>
    <name>A0A010YND9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570153.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2776"/>
    <dbReference type="HOGENOM" id="CLU_017779_0_0_11"/>
    <dbReference type="OrthoDB" id="295054at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="369" mass="37329" checksum="215FEFE2DD576194" modified="2014-06-11" version="1">MPALRPGSIDEAAESLRALGGAGTPVRPVGSGSRAGWGGGATGTELHTTGLNRILEHNPGDFTAVLECGVPLADAQKVFASAGQWLALDPSPGGTIGGLVATADSGPARHRYGGVRDLVIGVTLVLSDGTVARSGGKVIKNVAGYDLGKLFTGSFGTLGLVAEVAVRLHPLPSGTATAVATFTDPSALAEAASGLSRRPLEALSLDAAWRAGTGRLLVRFGGVTATSQASRVASGLAGGPEVAVVEDDEPLWEAQRSAQRSPSGAVLKVSHRPTELAAVVRAADAVGATVVSRAALGLSWLAFPDADPDTVATVREQLAPAAVTVLDGGDRVSAPWPDLDAGVVAVQQRVKARFDPARIFRPGTFVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNG9</accession>
    <name>A0A010YNG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851144.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2796"/>
    <dbReference type="HOGENOM" id="CLU_021150_1_0_11"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="449" mass="45716" checksum="130CF68CECB280DE" modified="2014-06-11" version="1">MSAPLVVVGDALLDRDLDGDATRLAPDAPVPVVDLTDERARPGGAALAACLAAERTAREVVLVTAIGSGPDADTLRGLLAGRVRLVELPLRGDLPVKTRVRAGGRPLLRVDRGDGVPLPPSGADLDAVLRGAAAILVADYGRGVADVLRPNLRTVTRPGSERVVPVVWDPHPRGGDPVPGARLVTPNLAEAAGTDAAGLAARWGASDVAVTMGSRGAVLSRGSASPMLVPAPFVASGDPCGAGDCFSATVAVALADGALPEEAVSRAVAAASAFVESGGAAAWPGPSTTAVRRTEGLDGALALAERVRARGGTVVATGGCFDLLHAGHVGLLEAARRTGDCLIVCLNSDASVTRLKGPGRPLNTAADRTRVLTGLVSVDAVVVFDEDTPERVLGRLRPDRWVKGGDYTVDALPEAAVVRSWGGEAVVLPYLDGHSTTDLVHRASVGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNQ2</accession>
    <name>A0A010YNQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851231.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2872"/>
    <dbReference type="HOGENOM" id="CLU_091687_2_1_11"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041479">
        <property type="entry name" value="TetR_CgmR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17937">
        <property type="entry name" value="TetR_C_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="20617" checksum="504DCF04707DF6D5" modified="2014-06-11" version="1">MAQTRDAPRTRRILLDAAARAVLAHGATVSLEVVAREAGVSKGGLLHHFPSKDALFSGLVDDLMTQFDATVEAHLDPADDRPGRLTRAYVRAVFANLGHPNGADTLRHDATLMAALGHLPQVLARAQEDGRHWKEAFAQDGLHPQRSALITRAADGTATASLFEGRLEPRELAETRDLLLALTEETGPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNV5</accession>
    <name>A0A010YNV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851310.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065741_0_0_11"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="27126" checksum="09C7F30C1569F48B" modified="2014-06-11" version="1">MDSTTRTNRRAWEAASEKYVREHDEWLAVAADGSSLHDFERALLRDVLAGAPDVVHLQSGNGTDDVALVNAGAASVVGVDFSEVAARAAQRRADQLGVACRYVVGVLPGAPLADAGADLVYTGKGALIWMPDLRAWAADVARLLRPGGHLFVYDEHPAFSVWTWDEDEPRVRPDRSYFAASHADDTFPANGAVQFQHTLGETVTAIVSAGLRIRHLEEYAEPFWRMGGVDAASWGGRLPNSFSLLAQMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ16</accession>
    <name>A0A010YQ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="32568" checksum="C1012EEFD11B8FD2" modified="2014-06-11" version="1">MVRDRPPRSNDDMAATDTGSGTGPLAPGTHEISTDGVRQVYHVAGRGPVCVAHPGGPGLHWAYLRSPDLEEHFTVVYPEPVGTGRSGRPPRYGVDVYRHFLAALIEHLDQPVHLLGHSHGGFVAQSYALASPQRLAGLVLYSTSPQAGPEFWAEGMSALAAHPQRHPDVPEAAGVPAAFQQALTATDEDSLNRAFAAALPVYFADFYSRKSEYAAFRATVLMAAEAAGASDPVPFDVSDRLGDIAVPTVVIVGEQDFLCGPRWGSLLVEGIPGAHLHLLPESGHFAHVEQPSLFTAAAVSLLQRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ31</accession>
    <name>A0A010YQ31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851960.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3394"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_1_11"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="23915" checksum="0085A13C402AD071" modified="2014-06-11" version="1">MSATPVRNVVLVHGAWADGSGWRAVHDLLTGEGYAVSVVQHPTSSLADDAVITRRVLDQQDGPAILVGHSYGGAVITEAGTHENVAALVYVAAFAPDQGESVNTLISDPVPGAPTPPILPPVDGYLLLDRDAFPEAFAADLPAADARFLADSQLPWGLEAVGGPITEAAWRAKPSWYLIAAEDRMIPPAAQRAMSERIGASVTEVTSSHAVYISHPDSVVSLVRAAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRF8</accession>
    <name>A0A010YRF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210195_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457912" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="59" mass="6364" checksum="A64C9EDCD598F8FB" modified="2014-06-11" version="1">MTRTMGKLADRLLSAFVPQTTAAAEVLYKCTPCGGTNALCRQYCFGNCGPWYCDTCGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRG9</accession>
    <name>A0A010YRG9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852719.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3952"/>
    <dbReference type="HOGENOM" id="CLU_095990_0_0_11"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20664" checksum="C1E3DAD6836125C7" modified="2014-06-11" version="1">MTPEPVAIAETRLLHTMHRAATSLLAEAATRDTSAPAALTELRDFLVAALRHHHESEDDVLWPRLAAAGAPLADLSAEHDVLDAALDRLAAAAVPGPQLAAAAADVRDLVHQHLDHEEPVLFPALAAHLSDQEWAAFSSAVIASAPPVGLHLNFGFFERVGTPEELAAVAANLPPEALAAVPVLREQARATLKGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV09</accession>
    <name>A0A010YV09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein containing Zn ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847328.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.5"/>
    <dbReference type="HOGENOM" id="CLU_087206_0_0_11"/>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG78993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21074" checksum="D9FDF8FA59171BF3" modified="2014-06-11" version="1">MSEEPAKSPAEPPPGTEPAPGTQPPPYAGTGPSGPQLARAALDAARAAGRTYTTRPEAPKRQPGDGQSPKRRRWSSAGPDPRDPQPLGRLVRRMVAERGWDRPTAEARVIGDWESLVGPEIAAKSKPVGLRDGELTLQAESTAWATQLRLLSGKLLGLLSAEVGPNVVRKIRVHGPAAPSWKRGPLSIRGRGPRDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVB1</accession>
    <name>A0A010YVB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2045775_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="12439" checksum="B8085E8E4D82B541" modified="2014-06-11" version="1">MGPFAEQHVNDTEDELPSDHASGPSTAELLETGEPAEATIVASGSLGMRSPYGASLYEFVLNVTRSDAEAYEVRIGNPVPPAAVPLTFPGAQVAVRVLPANPGAVAIDWEATLAAVQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVP1</accession>
    <name>A0A010YVP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847714.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.218"/>
    <dbReference type="HOGENOM" id="CLU_762700_0_0_11"/>
    <dbReference type="OrthoDB" id="889006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="42013" checksum="9EF20DDFD5D0DA27" modified="2014-06-11" version="1">MSAQGQDSVSPPVRLARKLRDLRRSGLGRRLTQEQLGQLLGGAEPLSAPLISSWERDTQPTVPPEGRVRAYARVFATQRSLSEGIVEEDDLSEVEKEHLYELESELVGLRAAAIGAAEADSPSAGAAVAEPPIGRAVGYGTWHFGDQRPVVIVASELPVDERPGYASSSSPDYVELFRYADLDSMVEAYGHIRAANPQNNRVRFRPASALTRDDFASHLVLLGGVDWNPVTRDLLRRMHLPVRQVSADNRVQDAYFEVVEGDRRRQFRPQVIADQGAAELIEDVALFYRGPSPLNRRRTVTICNAMFGRGTLGAVRALTDAWFRDRNESYLAERFGDAEEFLLLIRVPVFAGNTLTPDWTLEENRLFEWSRTAGQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW43</accession>
    <name>A0A010YW43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847946.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.377"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="26381" checksum="74D00C6C02353019" modified="2014-06-11" version="1">MAKAAWVTGGASGIGAAVSRRLASQGYRVLVTDVDESGGSAVASEIGGLFKRCDVTSPSDSLDAVAAATEAFGGLDLAFLNAGVATGFALEEGFSPEAYRRVMSINLDGVVYGAHAALPALKARGGGDIVATASLAGLTAVPFDPIYGANKAAVVGLVRALGPLYTADNIRVNALCPSFAETAIITNVRDALIGAGVPLLDVADVVAAFDSILAGDGTGEAWYVQVGRPAEPFAFRNVPGPRTPAGDKAPSADASVQTSLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWJ0</accession>
    <name>A0A010YWJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="4" type="ORF">CryarDRAFT_0559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848240.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.546"/>
    <dbReference type="HOGENOM" id="CLU_070326_0_0_11"/>
    <dbReference type="OrthoDB" id="1107067at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29272" checksum="C8D7244B3ACE5743" modified="2014-06-11" version="1">MRMAFSPCPNDTFVFHALVHGLVPGAPPVTVDFADVDVTNGAAERGEYDLVKVSYAALPWLLDKYTLLPCGGALGRGCGPLVLTTGSDSVEGKTVAVPGDRTTAYLLFRFWSAERPPARVVVRPFHEIMPAVAAGEVDAGLVIHEARFTYQRYGLHAAADLGDWWESTTGLPIPLGAILARKDLEARTGITPAAAAKLVRASVEAAWADPGASRGYVLEHAQEMEDDVVDQHIGLYVNEFTRDLGTDGYAAVDALLGRAAGAGLVPPVAIPRLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXY1</accession>
    <name>A0A010YXY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569788.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1104"/>
    <dbReference type="HOGENOM" id="CLU_071811_0_0_11"/>
    <dbReference type="OrthoDB" id="1520004at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="28269" checksum="654886F14A8BB72D" modified="2014-06-11" version="1">MTTTAQAPGRTTLLNQIVAIEKSVKARAKDAQSAIHQQMQRGSLDAALTGLIRTYRPIDDEGVRLPDERTRVQVHVEELLDEAARTLSRLFDVTASKDETNTRARGDIVVDGETIAADVPVTFLMTAEKELVDWRGVLAKLPVLDIAEAWTRDVDAEAYRSEPRETTRTAKVPRVQVLYEATEKHPAQVTSYNEDVVVGFWTTVKLSGAIPAGRKATLLDRVDKLVAAVRMAREQANLAAVVDKPLGAALTGYLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYT4</accession>
    <name>A0A010YYT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038663_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="507" mass="55460" checksum="9744BF960ED95CBB" modified="2014-06-11" version="1">MTTQTPARASTGGRDRYFDVLRFLCILWVVVYHIFSTEAWLGFWPAMGLLFAISGSLMVRSLDRGALKTIKNRLQRLLPVLWLAGLIGIPLMFWHGWPADERPPLWRLVFWIFPLSDPPGSEWAASLTEPLWYMRSIVWFILLSPLLLILFRWYPRTMITIPLLVMVGVATGKIGFGWAGELGEGVLTDGFTFLSLWLLGFAHREGMLKKIPVPAVVTGGLALAALATFWAFTHQEENSYDFNLIPAGQAIFSFGIVLILLRFAPKFSWVGNNKALDRLITIVNGRAMVIYLWHNVAIELSYPVGDKVGVWKLGETAGTAVCAVIAVVLTILGMLAFGWIEDVAAQRRPQLLPKDLGKKGGASTPAAPAAASGVTGGGQPEPPVAANVDDSTVSLPVSGAPVGTPPGGGWSATPASRPDERPQPRVYGSRPASPDDQQYENDRRLPEQRRSSEPATYGTPRTGRFPDVPAQRDDVGWSAGPGTPQSSRGRDERPPSFDETGTIPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYW7</accession>
    <name>A0A010YYW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146066_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="89" mass="9903" checksum="FEFCB7563FC5A2B3" modified="2014-06-11" version="1">MRNAGRAVMAITVTLVLVICLGIFFVLANANQTNMIVDFVTDIGRWLTTPFQNLFWMDNRDQAVLVNWGIAAVVYLFVGSALARLARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ88</accession>
    <name>A0A010YZ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein (PGPGW)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1590"/>
    <dbReference type="HOGENOM" id="CLU_107965_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="14449" checksum="859CB62982FF24E9" modified="2014-06-11" version="1">MTGLAWVTVAVKRIVVAVVGAVLLLVGVALLVLPGPGLLLVLAGLIVLASEFPGLERHVEPVRRQAMRAADESVSSPWRIAGTVVFGLFMIGAGVVWGVVDSLPLSGWSTGTSLILSGLVVLGLLVWSYRRVRSQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0Y2</accession>
    <name>A0A010Z0Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2161"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="40940" checksum="858D63F8CC33B765" modified="2014-06-11" version="1">MLPNHHGSAVTAVPDRGSVVRRPAPTGYGGSAEGGGSVARVTLQTIADQVGVSRMTVSNAFSRPNQLSPTLRERILAAAQELGYVGPDPSARALAKGTTGAVGFLLTESLGFAFTDQVSTQLLGAIAEELKPTGLALTLLSALGTGDIVPARDVAMDGVLVYSCDPQAPAVGWLRRRRLPMVFIDQDPVDEIPSVNVADRAGARASAQHLIDLGHRRIGFAMSGLRGPLGLIGNIEVVADQLVSGYASRERLAGWMEALNGAGLESPLVVRQLDDAVEHTSGAARLLLDRDDRPTAVLCFSDAIAFGVIRAANDLGLRVPEDLSVIGFDDHPLAGTFRPALTTVRQDVRAKGRAAAEALAAALGRGPAGPVPHVVLPTELVVRDSTAPPPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1X2</accession>
    <name>A0A010Z1X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850748.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2503"/>
    <dbReference type="HOGENOM" id="CLU_094953_0_0_11"/>
    <dbReference type="OrthoDB" id="1729032at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="34"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="22755" checksum="FB55DF4ABCAA619C" modified="2014-06-11" version="1">MSVISPGFTGRRRHDRDLPPGQYLTEDFPVLTYGPTPQVDLEEWNFGIVTETGAIHGWGWEALQALPRETPHVDIHCVTKWSKLDTDWEGVSLDTLFENIETEAEYAKVYSYGGYSTNLPLEDLLDGKAWIAFGFDGQPLEPEHGGPARLLVPHLYFWKSAKWVRGIQLLLEDEPGFWEENGYHNYGDPWREQRYEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1Z3</accession>
    <name>A0A010Z1Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850789.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2523"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35999" checksum="9C5A269522150C60" modified="2014-06-11" version="1">MATTITAPDEAPPDPGSPPRRKRRRTPALPYLLLIPAIVLELAVHVIPMLTGIWMSLKELTQFHIRDWSGAPFIGLDNYKVALDFNSATGKELLHSFWVTALCTILVVGLSYGLGLAAAVLLQRPFRGRALLRTLFLTPYALPVYAGVIIWSFLLQRDTGALNHILVDQLHVVDDRPFWLIGGNSFWSLVIVMVWRHWPFAFLCLMAGLQGIPQDLYEAAYMDGAGFWRRLRAVTLPMLGPVNQVLLLVLFLWTFNDFNTPYVLFGKAAPDQADLISIHIYESSFVTWNFGLGSAMSVALLLFLSVVSGIYLFLTRKARADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2H5</accession>
    <name>A0A010Z2H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein involved in propionate catabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851025.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2708"/>
    <dbReference type="HOGENOM" id="CLU_026574_1_1_11"/>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="275"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="472" mass="49342" checksum="2A07892865A3AFFA" modified="2014-06-11" version="1">MAEPTLAQRLGAFAADAADLPGEVTDSVRKRVLDILGIAVAAASLETSRAARRWAAEQGGTPEATAIGRPEKLPATQAAFVNGVLAHSLDYDDTHLPSVLHPSAVVVPAALAAAEATHASGAQLETAIAVGLETAVRLGMAGYDQESNNSVFFEHGQHATSICGAVGAAVAAARLHGMDAARTTDVIGVVASMASGLIEANRTGGTVKRMHCGWAAHAALSAVGLVRHGFTGPPTVLEGRFGFFQAWLHGVFDASQITDGLGESWAVPGIFFKPYPANHFTHAGIDAARRLRAKGVDPAAIRSIRLGVPRQNLPTVGQPIEVKRAPETGYMAQFSGPYTLVAGLLGGGGLGVGLDDFTDELARDPHRRALMRLVEVEPDEKCTAIFPYQFPAVVTLRLDDGTELTEEVLVNRGGPGDPLSFDELATKFRDNAGRALPAEAVGALAEAIAGLHDITDLSALLEPLREVDAHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z334</accession>
    <name>A0A010Z334_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_2938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851263.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2900"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="46450" checksum="EC70A7DBDE34CD3C" modified="2014-06-11" version="1">MVEWLLVLLGLLLVAACGVFVAAEFAFVTVDRGAVERAGAGGVDAALRTLSTQLSGAQVGITITNLAIGFLAEPSIAALLEGPLGALGLGDPAVTGVAVALALTLSTLITMLFGELVPKNIAISRPLGTAIAVAPLQRGFTRATLPLIRLLNGIANGILRRFGIEPQEELSSARAPEELVSLMRRSAQMGTLPGETAELLGRTLGLGRLTAADVMTPRSRLTVVNADDPVHTVLTATGRTGHSRFPVVGEDIDDIVGLVHAKHAVGVARDARTSVPIRSAMQPPVFIPGSVPADDLLPQLRREGLQLAVVVDEFGGTEGIVTLEDLIEEIVGEVADEHDRSQPAGLRRRPGGGWVLSGLLRPDEIREGTGVPVPDGPEYDTLGGYVTVRLGRLPRLGDEVLVVSTPADVDAEPVRFRLEVDRLDGRRVDRVLAIAEPAGGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z394</accession>
    <name>A0A010Z394_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851350.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2963"/>
    <dbReference type="HOGENOM" id="CLU_034180_13_0_11"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="230"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="43126" checksum="21A9A16088FE45DF" modified="2014-06-11" version="1">MNSARRAGPSIGELLAPARLGGSFRWLLASSWSTNLGDGVAAAAGPLLVASLTDSPPAIAAAALLRWAPPLVFGLYAGVLSDRHDRRRIVVLADGSRAVVLAVLVVALATDRLGVAGALLALGLLATAEVFADNTTATLTPMVVSSDDLVLANARLQVGLITLNQLAGPPLGAALFVAGQVWPFVTQAVLVAAGVLLIRRIRPVAPEARPRSTARREIREGVAWTVRHAAVRTLALTILIFNVTFGAAWSVLVLYAQDRLGLGAIGFGLITAVSAVGGLLGSVLYGPITARVSLGNVMRVGLVIETLTHLGLATTTSPLVALPIFFVFGAHAFIWGTTSTTVRQRAVPTHLQGRVGSVYTIGLYGGLVVGAAVGGVLADHFGVAAPFWFAFAGSAVFLALLWPSLTRIVHAEPPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3S3</accession>
    <name>A0A010Z3S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570294.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3130"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="856"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="919" mass="98226" checksum="9C4A8609F405C05D" modified="2014-06-11" version="1">MGQTATGEALVDIELFGRKAELERLSEFVTGLTGPDRPSGGARLIRGEPGVGKSVLLAATAELAGPAGVRVLRASGSEFEADVSYSALNQLLLPLHADLDRLTPGPREALSVALGFGVGPAPDALLVCNAALLLVTAVAVDTPVLLLIDDVQWVDRASAVALGFIARRLVGCRAGLLASARTGAATFLDPRGTAEITVAPLDLAAAGQLVDARLPQLPPRSRRRLLDLARGNPLALVELPSTLGDARYPVDVVPLSERLQAMFTTRIGDLPEPTRRVLLLASFEGTGDTGVLRLVLDQGLVDLAPAEQAGLVRVDDSTARVVFRHPLIRSAVVAVSAHEERRRAHIDLAAALPDDEERRAWHLASAAAGPDEAVSDLLERVARRVMVRGDALGAVAALVRAAELSPASTERGRRLAEAAYIGAEASGTVDHAQSLLLDARRAAPDSAGSLHAANAAAFLLLNGDGDVSTAHRLLVGAIETGGHGYRADDPALIEAMHTLLLLSWYGGAPEYWEPYYQALGRLRPGPPELLALTSRTFPDPVRTAARALPDVDAFLDGLSDEADLSRTVRIGTASVYVDRLGDCRESSWRLVRHGREGGPARRHLGALMHLCLDDYLVGRWDEAERLAAEGQRVCAAGGFSFFAWYFQYNRAIVAAGRGRFDEAGALADDMTHWALPRGVRAAVLFAHHPRALAAVGRGDWEGAFLHASALSPPGALASHVPHCTWVILDLVEAALRTGRTAEARAHVDALRTAKIGSLSPRMELLQAGAEFLVDEERPATRLEDLLASPAADRWLFEASRLRLALGERWRRTRSSARARRHLLAARDGFAAMGAEPWVERANGELRATKYRVADIPAGGPAVLTPQEFQIAQLAATGLTNRQIAERLRLSHRTVGAHLYRVYPKLGIASRAGLRDALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z408</accession>
    <name>A0A010Z408_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851709.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3222"/>
    <dbReference type="HOGENOM" id="CLU_110158_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="19911" checksum="A18ABF629C7F3BB0" modified="2014-06-11" version="1">MTPALSGTQPAILAAYAELIEEVGSDDVSNRAIGRRAGIGERTVFRNFPTRVDLLLATAAWIEATLFAREESASIFDVPLAIRDAMQRYDARPELAHVVAETAMRGVSGAAPSPGRAQLERLLDAEVPSLGAAERRSVVAALSHLDSAGARVTFRREFGMDRRDIADAAAWAAEAALDTIRDRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5V5</accession>
    <name>A0A010Z5V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570640.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458954" evidence="7">
        <location>
            <begin position="35"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="182"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="683" mass="69483" checksum="6D1A79C31E1FF10E" modified="2014-06-11" version="1">MESVLYRLGRACFRRRRLTLAVWAAVLVVLGVGAATLSGPTDDAVSLPGTESWRALDVVDEEFGESTSARVVFTAPGGAALTGPDRQSAVRAAVAALRDAPQVAEVSDPYQAGTVAPDGRTAYATVTYPGPATDVGADSRAALREAGDTARRAGLDVEYAGEVTETEEASSGTELLGLAVAAVILLVTFRSVVAAGLPLLTAIVGVVAGTLGISIATGFLDLPSNTAALATMLGLAVGIDYALFLLSRYRHELAAGRDGEEAAGRAVGSAGTAVVFAGLTVVIALAALAVVGIPLLAAMGVAAAGTVAVAVVLSLTLLPALFGVAGRRIGPRAGAGGRGERWTRSVVGHRVVASLGCAVVVGLLAVPALDLRTALPDAGSAPAGSTQRAAYDQLAAAFGPGVNGPLLVVVQGADVAAPSARAHRFVAGLEGVVVATPPTANRAGDTAMFSVVPATAPTSDATRDLVHAIRADRAGLSAASGGATLAVTGRTAIDIDVSEKVNRALRPYLAIVLGLAFVLLTVMLRSILIPIKAVLGFLMSVAASFGALVLVFPSPLDSFLPIFLVGVLFGLAMDYEVFLVTRVREEHLRGAPPDDAVVTGTGYSARVVTAAALIMISIFASFVPSDDGIIRTLGFGLAVGVAVDALLIRMTLGPAVLSLFGRAVWWLPQWLARFLPNGGVRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKJ5</accession>
    <name>A0A010ZKJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847654.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_11"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="182"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="46479" checksum="F110498325714006" modified="2014-06-11" version="1">MTTPKKATRRPNGASSIYEGSDGWWHGRVTVGIRDNGKPDRRHVRGKTQAAVIRKVRELEKERDSGRVRKIGTPWTVEAWLTHWLENVARPTVRQSSYSAYEVAVRVHLIPGIGAHRLDRLTSEHLDSLYTRMVAKGSSAGTAHQAHRTVRTALGVADRRGYLPRGNPAAKGMVKPPRIEEEEIEPYTVEEVRRLLAEAGKRPRNSARWAMALALGMRQGEVLGLKWADVDLDAGTLRVRRGRQRPKYEHGCGGTCGRKAGYCKQRKNVRSETADTKSRAGKRPIGLPTELVALLRKHKEAQEAERAKAAQLWQDEGWLFATPTGGVLSTNTDYHDWKDLLKGAGIRDGRLHDARHTAATVLLLLGVPDRAVMGLMGWSNSAMAARYQHLTAKVRHDIAKQVGGLIWQAEEETEKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLB7</accession>
    <name>A0A010ZLB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848121.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432372_0_0_11"/>
    <dbReference type="OrthoDB" id="1161729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="21079" checksum="30C84E5D14A81F76" modified="2014-06-11" version="1">MPSVRTNSDLYLAMSRLGSSTRRPLEEFLRSWWSTGYDLSDSKALEPDELLSWISDALTAPAPPFEKYWAREDLDLSELDGFSGWSRVIRAQVCDLTEMASLGVLRSQASYLGLSAPRPPGTGRRPTPPVWFNLDVASYLESGVIATVGGWRPEFEDALVDEEPPEPLPIGSFDWEDLTRFALGAQTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLC2</accession>
    <name>A0A010ZLC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="13" type="ORF">CryarDRAFT_0502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848133.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.485"/>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_11"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="461" mass="50396" checksum="0B5E133A9275774E" modified="2014-06-11" version="1">MTLRLHDTASRSIREFVPITPGRCGIYLCGPTVQSAPHIGHLRSAVNYDVLRRWLTRSGYEVTFVQNVTDIDDKILAKAEDVEWWALAYQNERAFADAYAALGCLPPTIAPRATGHVPEMVELMKRLIERGHAYDAEGDVYFDVQSYAEYGALSGQRLDHMQGDGADDHCKRDPRDFALWKGRKPEEPTTASWPTPWGPGRPGWHLECSAMAGRYLGRAFDIHGGGLDLVFPHHENEIAQSKAAGFGFANYWVHHALLNLGPEKMSKSLGNVIDLPKVLGLVRAIEFRYYIATPHYRSTIDYSEEALLEAAVGFRRIENFVERAVERVGPVDGVPGAAFTAALDDDLGTPAGIASVHEAVRVGNAALAAGDEAGIRSALAEVRGGLEVFGLDPLSTEWAASEAGSADDLRNVVDSLVKVALEQRQAARARKDYGASDGIRDQLKEAGIVVEDTPAGPRWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNJ7</accession>
    <name>A0A010ZNJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849054.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1288"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26705" checksum="6B083385EA241588" modified="2014-06-11" version="1">MPRTVRANILITGASSGLGAGLAREFAARGRNLALCARRLDRLETLREELVSANPGIRVAIHSLDVTDHDAIFRTFRSFASGLGQIDRVVVNAGSGRGASIGTGRFAANRETAETNFVAALAQCEAAMELFREQNSGHLVVISSIAGLRGGRRGAGVYAATKAGLSTLAEGIRLDVADTPIRVTTIEPGYIRTDLNAGATTLPFAVDVATGCRALARAVEREPASAYVPGWPWRVVAPLYRIAPAPLLRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ03</accession>
    <name>A0A010ZQ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type VII secretion protein EccCa/type VII secretion protein EccCb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847793.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.280"/>
    <dbReference type="HOGENOM" id="CLU_003134_1_0_11"/>
    <dbReference type="OrthoDB" id="7548at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="458"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="817"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="481"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="835"/>
            <end position="842"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1317" mass="143282" checksum="0AC5375D229A59AC" modified="2014-06-11" version="1">MGTVIVKRPPRRPAPGFPEGELILDAPPAIPPPSGRAWGQAMMMLPMLAGSAAMALMFAGTGGAGSTLRWVTGGLFGLSAIGMLSTQLGSYSGQPNKQQMASQRREYMRHLAQLRRRTRTAVQTQREAMFYRHPEPATLWTTAASYRLWERRPADDDFAVVRIGLGPQDLATPMVPPAITASDDLEPLCAQALRRFVTTYAVVPDMPVALALNGFARIYLRGDSAHVHGLARALLAQVTTFHAPDDVRVVICAAPDRLVRWEWVKWLPHAQHPERTDALGPVRLVAPTVMAAEAMLDDLLSGRPRFNPTGAGQEVAPHLVVLLDGADPAGSDHLATDNGIEGVTLIDLAAPPLRLLDATVLVLDVDRTGRLRSTTMEGDADIGSADELGTAQAESLARQLAPLRLSAAARGERPLTAEMELAELLGLGEPRQFDPANAWRPRPSRERLRVPIGVGQNGAVVELDLKESAQDGMGPHGLLIGATGSGKSELLRTLVLALATTHSSELLNFVLVDFKGGATFTKLDRLPHTSAVITNLEDELPLVDRMTDAINGEIRRRQEVLRAAGKFESVRDYEKARAAGAPLDPLPSLLIICDEFSELLSAKPDFIDMFVQIGRLGRSLGVHLLLASQRLEEGRLRGLDGHLSYRIGLRTFSSMESRVVLGVPDAYELPRAPGHGYLKFGTEEMTRFRGAYVSGVYREGGRRAKTSSAESTPVRPFSTAYQPLRGELKDESEPPVPDPDEGVGESLLDILVERLQGRGVPAHRVWLPPLDQPATLDQLLPPLAVEPGRGLTVTDPSRRGALRAVVGLVDRPLEQRRDLLTLDFSGSQGHAVVVGGPQSGKSTLLRSIVAALALGQTPREAQFYCLDFGGGALAALRDLPHVGGVASRLEQGKVRRTIAELRTLLLDRERRFAREGIDGMSTYRRRREQGEYGDDPFGDVFLVVDNWLTLRNDFEELESQVTDLANRGLSYGIHVLISASRWMDVRPALRDVLGTRLELRLGEPSDSYLDRRTALNVPDSTPGRGITADKFHFLGVLPRVDSRSETADLSDGVAKLVQDMANAWSGPTAPPVRLLPAEVPYASLVGPETLIGIAESDLGPVSVDFTADPHFLLFGDSESGKTAFLRQLARRITDAHAPDEARLIVVDYRRTLLNEVSPGHLIGYGSSAPVTEQIVDEVATVMRNRLPGPDVTPEQLRERTWWRGPDLYFLVDDYDLVSSGSTNPLGPLFELLAQARDVGLHLIVARRSGGAGRALYDSLLLRLRELGSPGLVMSGDRDEGVLLGNVRPQALPPGRAWFVTRKEGSRLIQLGWLPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQV3</accession>
    <name>A0A010ZQV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850204.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217708_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="23644" checksum="9588166C4FB462BE" modified="2014-06-11" version="1">MSAPAPAPAPAPVTTAAEDQLLLLGANLLPPEIVARRQVGKIRLVAVAILVVTLLLVLAVYAVAWTQKVRSRGDFDEVTASSNVLRAQQGKYRELIVAQTAADQIKGQLATLMADDVTWTPVLRSIRAAAPSGVGLTGLILTVTDPTQRSSEGVMTSSGLPSTTGSPIGALTITGTGSSNAAIATFVDSLAKVSGISGALLTNATEQDDGIVFGVRADLSPTLLSKLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRI4</accession>
    <name>A0A010ZRI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848589.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.837"/>
    <dbReference type="HOGENOM" id="CLU_003827_19_1_11"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="461" mass="50341" checksum="8A609A061B8D04E5" modified="2014-06-11" version="1">MTATLNNQYVPAHGVRAPAGRAPAVRVGPIPVLVGIGVGAVGALWLWWTNTTTISGLGDWLTNAGRITGLLAGYGAIILLGLMARVPALERGIGTDRLTRWHAMGGRYTVSMLVAHGLLITWGYAVTARTSVVGQGLSLIKDYPDVLYATIGAVMFVVIGALSARAARKRMSYEAWHLIHLGTYLAIALSFLHQFSTGADFAGNKPAQYAWSALYGVVSLLLLWYRVLTPLRSAMRHRLRVEGVRMEGPDVVSVYLSGRYLDELKAEPGQFFRWRFLTPSSWWASNPYSLSAPVSGGRLRITVKEAGNHSASLAQLQPGTKVMASGPYGAFTGGVRRRRKVLMIGAGVGITPLRALLETLPGRPGDITLIYRARHMSDLVLRAEIEEIAFDRGARVHYLVGTREQLGGDPLSAEQLEYLVPNLRHHDVYLCGPESLTAATRESLRDAGVARRRIHHESFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRJ5</accession>
    <name>A0A010ZRJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848608.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065811_1_0_11"/>
    <dbReference type="OrthoDB" id="1666716at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="21172" checksum="D15CC5A3B7423025" modified="2014-06-11" version="1">MIRRAVLFELRIYRNLARWVARRPDVRGGEPFGYAQLVTPVLCLWIFGSAVETVVVHFILPWEGIRLVADIVGIWGLLWMLGLLAGMRTYPHLVTPQGLRVRHGGNFDLKLPWEIIASVTTQRTNLESSIRTLRLIDDELFVAVNNEVNVRVVLTEPIIVKDREVTAVSFLADDPKALVARAKAPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRW5</accession>
    <name>A0A010ZRW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848728.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.998"/>
    <dbReference type="HOGENOM" id="CLU_025908_1_2_11"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="31986" checksum="CF670D10DEA52586" modified="2014-06-11" version="1">MRVAAIDCGTNSIRLLVADLSDDTLVDVVREMTIVRLGQGVDETGRLAPEAIERTRVALAGYASQIRELGAERVRMVATSASRDASNADDFRAMVLSTLGRAPEVITGDEEARLSFDGAVRGLRSGEPPYLVVDIGGGSTEFVLGTDGVDAARSVDIGCVRLTERHLRSDPPTAAEITATERDVVAAVDLAREVVPVEKARTLVGLAGSVTTVTALALGLTGYDPAAIHHARISRDQVTEVTDRLLTQTREQRAAYPVMHPGRVDVIGAGALVLRVIMDQVGADSVVASEHDILDGIAWSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRZ3</accession>
    <name>A0A010ZRZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051571920.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458065" evidence="5">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="68"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="15721" checksum="25F19F7698487124" modified="2014-06-11" version="1">MDNTRYTRGLLNRRSVLAGAGAVGVTIVASACSSYGDSASSDAAPASSAPAAAPTTGAASAEAPPAADALAKVADIPVGGGKIFDAEGVVVTQPEAGTFKAFSNVCTHQGCKVNKVATTIDCPCHASKFSISDGSPTAGPAKKPLAEKQVTVNGDSITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS48</accession>
    <name>A0A010ZS48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848812.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1966884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="14207" checksum="05208AF59020DD1A" modified="2014-06-11" version="1">MVDVRKEEHGFSETEPGFEAERAERTRLVDAFLAAMGEAGNPGTSRKLGSFMRELTGQHQDRYWATEVEGDGDGVLVFADGRHGWERSFRSSDRPMSPDDEIPPDRLADALRVILDENDVSRPSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS52</accession>
    <name>A0A010ZS52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850837.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068396_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27413" checksum="19A1DD7005EA5AD8" modified="2014-06-11" version="1">MSDTVSHHPAAEAPAVDEDAGGLAFVGESMGEEPPPRRRRRWLVLLLVAALAVPGVVCVGFAASFSSVVHRDPPPDLESPAVIGAHEDTVRLVTAALTTATPAGTTPVTTARYDACVRGSRQLKAWDDFDWVCATRGAAVLSLPAADLRATLSAERSRLAAAGWTVVADRLDARFASAEERAWNVVELDRDGVRLALSYGPADRAFAGDCVLLQKVDVSAWATPNWEVGSPALDGAALDAALRPGVALVLVTAQRVWFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS77</accession>
    <name>A0A010ZS77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848856.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1113"/>
    <dbReference type="HOGENOM" id="CLU_021628_0_0_11"/>
    <dbReference type="OrthoDB" id="732251at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="545" mass="57203" checksum="E0F40DCF99111B22" modified="2014-06-11" version="1">MYQQVLDPVAHSLAWSSLIAAIPLLVLFVLLGVFRLRAWVASLIALAVALVVAIAVYGMPVGQALLATSEGAAFGFFPILWIVINAIWVYNMTVATGHFDVLRRSFTSVSDDRRIQAIIIAFSFGALIEALAGFGTPVAVTSVMLMALGFSPIKSAVLALTANTAPVAFGAMATPILTLGTVTGIDSDTLGAMVGRQTPILAVFVPLVLVFIVDGARGLRETWLYALVCGLVFGFAQYVTSNFISVPLADVVASLLSVAAIVAAVRLRRPLVTPVTAHAFSAEGPAEPVTEEREPAEPDSRAEVMRAYAPYAIIIGVFVICQIGPVKEFLERATTVVDWPGLHLTNTSGKELSSVAFKFNWFTTPGTQMLVAGLITMIVLRVSVGRALRAYGATLNQLKWAILTVMAVLGLAFVMNASGQTVTLGTWMAGAGGLFALISPILGWLGVAVTGSDTSSNSLFGALQVTAASQADLSATLMAASNSSGGVLGKMISPQNLAIAAAAVGLDNREGDIFRRVVGWSAVFLAGICLLSWLQSTAVLSWMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSC4</accession>
    <name>A0A010ZSC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570121.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_11"/>
    <dbReference type="OrthoDB" id="2012139at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="13264" checksum="A02F5C5F0B6E0788" modified="2014-06-11" version="1">MARLLVVEDEPDLRDLLVHRFEAAGHEVVPVATSAAALRTVEADGPPDAAVLDVDLPGRDGVDLLADLRRRHPALPALFITVLWSGELLARMKATGCPYLTKPFAARDLRDAVADLLHGGNTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSX0</accession>
    <name>A0A010ZSX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">CryarDRAFT_1371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849125.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1347"/>
    <dbReference type="HOGENOM" id="CLU_019250_2_2_11"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="259"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="512" mass="53950" checksum="FC35499FE8067A60" modified="2014-06-11" version="1">MKGALLVAGATSDAGKSLLTAGICRWLARQGVRVAPFKAQNMSNNAVVTPDGGEIGRAQALQAEACGLAPSVRFNPVLLKPGSDRRSHLVVQGRAAGEVSAMSYRDVKPRLLELVLGALDDLRRDFDVVICEGAGSPTEINLRATDIANMGLARPANLPTIVVGDIDRGGVFASLFGTLALLSEEDQQLVSGFVINKFRGDARLLSPGIDQLTAITGRPVLGTLPWVDGLWLDAEDSLSYSPDGVIGRGAPPLGSSWLRIAVPRLPRMSNVTDLDALAAEPGVQVRLVRHPAALADADLVVVPGTRETVDDLAWLRRTGLADAIVAHHAAGRPIVGICGGFQMLARTIADDVESKKGTVDGLGLAPVEITFAAEKTLGRPTGRSSGEVVTGYEIHHGQVTDRAPNVPAWITSDSGGAEGVRYTEGAGVVYGTHWHGALESDGFRRRLLAEISDQRSLVGFVVPPDTAYQQVRAEALDALANLVERHLDTNALIRLIDEGAPAGQPFILPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSY0</accession>
    <name>A0A010ZSY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849136.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1355"/>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_11"/>
    <dbReference type="OrthoDB" id="1567476at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="23613" checksum="13D72C79A5EF68EC" modified="2014-06-11" version="1">MSDYFADRAEAGRALAVAVADHLKEHEVPLVLGLPRGGVPIARTVAAAVHGELDVVVARKIGVPWHRELAVGAVTVDGPALFDRGLLGQVGLTLEELEPDVERERAEAVRRTERYRDGRPAPVVTGRTVVVVDDGLATGATARAALRSLRVLRPGHLVFAAPVCAPQAVAMLGAEADAVVCVAAPPEFRAVGYHYRSFPQLTDEEVEAELAAARRESASLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT37</accession>
    <name>A0A010ZT37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1882274_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="14875" checksum="8D4CFC68E854E873" modified="2014-06-11" version="1">MTEPGGFVVYSNWRTFPIPAAERAVSDPTGTLRARLSSQYRCMVFVLEGEIDARTAPWLTEQLLGACRERTGDALVLVLRHLSFFGAAGLQCLNTVAETAARRDVRVSLWDPPPFARRVLRAGDLHPSVLVEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT41</accession>
    <name>A0A010ZT41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2940"/>
    <dbReference type="HOGENOM" id="CLU_070584_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="26016" checksum="E4CD42B17704CF7A" modified="2014-06-11" version="1">MIDHAVALAEQDRRFADTLRGADLTAPVPTCPGWSLTQLLRHLGRGHRWAAQIVRERRDEPIDPRAVEGGKPPADDDGALEWVAGGGSILLDAVAPDPDVLVWTAVGPRPASWWIRRRLHESTVHRADAAIAIGAPYTLAPELAADGVTEWVELLVAGGRSPLADGESLHLHATDADAEWTLRGTASGLSFEPAHAKATVALRGPATDLLLAITRRRDVGSTVELFGAEPVWRSWLDRTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTE0</accession>
    <name>A0A010ZTE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of stationary/sporulation gene expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142061_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="111" mass="11555" checksum="507116C433952EDD" modified="2014-06-11" version="1">MYGVTALDDSGRILDRGVLSALGWGSGMRLTVGERGGLIVVAADPAGACRVTSQGFVVLPVALRHWCGLRRGDRVLVVVDPGRGWMVVHPPAALEAMVSAAHSAVWGGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTM5</accession>
    <name>A0A010ZTM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849511.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1623"/>
    <dbReference type="HOGENOM" id="CLU_057658_0_0_11"/>
    <dbReference type="OrthoDB" id="1938924at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="36966" checksum="7367AE917C03C14A" modified="2014-06-11" version="1">MTAPTVGTEADRYLQRVRAALADLPEDERNELIEDLSAHLADISAESPETLTAASLEQRLGRPEAYAAELRASAGLAPAPNVTATRRLRSVSERVRGRLDSVPAYRQFVAFLPELRPGWWVLRGYLFAVVVAAIFLGGFSGVLPDSDSDAVVFLVLAALAAYGSVWLGRRSDGFGRWGRRAVIAGGVFVGLVGLAIMTSSNGSDYYDTGSYYSGGQLADASDLRVYGPDGQLIRDAQVFDQNGNPVVLSGSCPTEQRTRTDGGVAENVYPRTVDPSIDPAYCTDDGRAPVAEQLPGLNPRVPTGVASVPISPTPSESPVPSESASPTGSPTSPAVPTSPAVPTSPAAPAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUC9</accession>
    <name>A0A010ZUC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1855"/>
    <dbReference type="HOGENOM" id="CLU_096072_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16398" checksum="900004AD01BB777F" modified="2014-06-11" version="1">MSRIDENRERLRSAGLRVTNPRLAVLTELTRGGHPTVDSLADAVRARLGAVSTQAVYDVLGVLVESGLARVIEPAGSARRYEARVADNHHHLVCRGCGQVEDVDCATGEAPCLVPADTYGFTLEEAEVTWWGTCSACASPSARSQRGVPQIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUL7</accession>
    <name>A0A010ZUL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type bacteriocin/lantibiotic exporter with N-terminal double-glycine peptidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570483.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3515"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="34"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="352"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="618" mass="65975" checksum="B8C33D16B6811C6A" modified="2014-06-11" version="1">MPPAAGPTAPDVSPRAAALMAVRIAWLASPRAVVLLAVSALVGAAAPVAVTWLTRAVIDQIVAGGPAGLLVGLATGVALAGVVTATLPQLDQYLQAELNRTASLTAIERLHGSVGRLIGLVRFEQPAFLDRLQMAVMSERGPADVVAGGLGAARSVLALVGFLVSLVVISPVMAVVVVVAAIPVLFAELALSRRRADMTFTISPNERRELFYRELLLRANAAKETRLFGIAGFLQRRMLTERRKADAARRAVDRRELAVQGGLALLGAAVAGGGLVWAVRAARQGDLSIGDIALFIGATAGVQSALSNAIGQFTLLHQKFLIFDHYRAVVTGPSDLPAVAHPRQAPPLREGIELRDVWFRYTPDAPWALRGVNLTIPVGRATALVGRNGSGKSTLIKLLCRFYDPERGAVYWDGVDLRDLDPASLRERVTAVFQDFVEYDLTAAENIGVGDVTAIDDEDRIRTAAQRAGVDDELAGLPAGYQTLLSRIFMTETDREDPTTGVVLSGGQWQRLAVARAFMRDGRDLMILDEPSSGMDAEAEYRIHAGLQRHRAGRTSVLISHRLGSIRNADAIAVMDDGVVVEEGTHADLMNTGGIYAHLFLLQATGYLEDQATVEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUM4</accession>
    <name>A0A010ZUM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3527"/>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15546" checksum="00D17CFFFC1EA153" modified="2014-06-11" version="1">MTEMPSTGAETALGGKPSVLFVCVHNAGRSQMAAGWLTHLAGDTVEVRSAGSAPAETINPAAVEAMREVGIDLTDQKPTILTVDDVRASDVVITMGCGDACPVFPGKRYEDWNLTDPAGQDVGVVRKIRDEIRGHVETLLTDLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUQ7</accession>
    <name>A0A010ZUQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850071.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_11"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="12877" checksum="40DCF358B372ED69" modified="2014-06-11" version="1">MSTVLIADDDPDILALVTFKVKQAGYHLVTATDGAAALAAARETTPDLVVLDVSMPRMSGLEVCRELRKDTATAKVPVLLLTARAQEADIEAGFDVGADDYVVKPFSPRELVARIAAILGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUT7</accession>
    <name>A0A010ZUT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852262.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3610"/>
    <dbReference type="HOGENOM" id="CLU_023898_0_0_11"/>
    <dbReference type="OrthoDB" id="116406at2"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="10">
        <location>
            <begin position="5"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="750" mass="83007" checksum="BD9EB277C4328E41" modified="2014-06-11" version="1">MTTTVAPHRLDAWRGFSGHRWRRAVDVQRFILDNVTPYLGDGGFLAGPTDRTTALWQRVSELMSVERQRGILDVDTVTPSTITSHRPGYIDRANELIVGLQTDAPLKRAIMPNGGLRMVENGLAAYDYQLDPGVRTIFTTYRKTHNDGVFDAYTPRIRAARKAGIVTGLPDSYGRGRIIGDYRRVALYGADALVAAKEAEKAALDDVRSGADVIRDREEIAEQIRALRELVTMAAGYGYDLTRPAATGREAVQWLYFAYLAAIKEQNGAAMSLGRVSTFLDVYLDRDRHEGRLTEDEAQELVDDLVIKLRMVRFLRTPEYDALFSGDPTWVTEAIGGMARDGRPLVTRTSFRFLQTLYNLGPAPEPNLTVLWSPALPEGFKRYCAQTSIDTSAIQYESDDLLRTRYGDDTGIACCVSATQLGKSMQFFGARVNVAKALLYALNGGRDEMSGAQVGPESEPVGGDVLDYDDVSARFDRMLDWLAETYVDALNVIHYMHDKYAYERLEMALHDHPVKRTMACGIAGLSVAADSLSAIRYATVRPVRDETGLIVDYRTEGEFPVYGNDDDRADTIAVELVHAFMQKLRRRPTYRGALHTQSVLTITSNVVYGTHTGNTPDGRRAGEPFAPGANPMNGRDRHGLMAAALSVAKIPYDDARDGISLTASTVPAGLGRTPADRVTNLVGVLDGYTDAGGFHLNVNVLNRETLLDAMDHPENYPNLTIRVSGYAVNFVKLTREQQRDVVNRTFHQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV02</accession>
    <name>A0A010ZV02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570003.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2098"/>
    <dbReference type="HOGENOM" id="CLU_394679_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="698" mass="71476" checksum="A9392D8072EA1BBA" modified="2014-06-11" version="1">MAVRDHAQLGAILHCLRSSLGRLGRIGPVALVRTLATVIAAVSEPPGGDPVRLADLAGAFRRARVDTDPVAGAGRPAEWSGSAVAAAAETVVATAHLVGSVHPAFDDAADALARYAATSAELRAERRELRARLTTAWHDATHVELFGRGVRVPDVRRLDDLAAAARPLIGGLLEVYRRGQDAVDTLTSQLDAVAARTRASALTADAMTLSAPEPLLAPPPGSPIPSSPNPDVPIRNRPIPDGPIPDGPIPDGLNPDDPAPGDPTRSGPTPDRLTLDHPIPGSLAAGDLAAGTPAADTPTAGDLAAGDLAAGTPAAGTPAAGTPAAGTPAAGTPAAGTPAAGTPAAGTPAAGTPAAGTSAAGASVASDLAAGPGADDPATGRDAGHRARYPSTNEPAPDPSLPALGREAGDPASTPGTNDPAADLAARQPVDLAVLPPWQLLRASRRRAALTPDERAAFERTLAGAGSPLERAYLWKALAAGHTVAAVETFAGRIRGRDSGWLRAHLSVVDPARRGPVTFAGQPFAQTDGTTCGTTSIVVARALADPIYTLEITRDPEAFREEQRRLHGRTNPVWPEALGTSPWGMQRGLAAETGTRYDFHWTDDTKPRERSAAIRAVLAAVDAGYPVPLLVGNTYPAHYLLVVAHDAGALLVYNPAGGRLTEVPADDILRATVFRHLQGYLTPRRAAARSPGRPGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV60</accession>
    <name>A0A010ZV60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2449660_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="89" mass="9108" checksum="2C1BE4E1C4FEBE5F" modified="2014-06-11" version="1">MEYIAAYFIARDADGQRMSTGRLDGRVEAPRASLWRRAARLVTRAVAARRASVGTASVGTASVPKVPATKASTAKASAAAAGRTGCATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV99</accession>
    <name>A0A010ZV99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3788"/>
    <dbReference type="HOGENOM" id="CLU_069356_15_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="27142" checksum="CC6EDA398941CA4F" modified="2014-06-11" version="1">MRDETRCRVCRADLRPSGRGRRPVYCSRACQAQAYRARKNPPEPAPAVPARQHRIFEAVWRIAAERGLRRATIREVAATAGVTPRVVQYHFTSKRQLLVGALEALHRDNERRARTRLAALRDASDPRVLLRATLEELLPLDAPRRRSLRVLSAYYEWSLTDAALAAVFLHAETPLEDLVATLITAAGPRPSIDPAREADLLVSGVTGLGVDLLHRRRSTADVRRTLDYHLARILEDERAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVC0</accession>
    <name>A0A010ZVC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2227"/>
    <dbReference type="HOGENOM" id="CLU_852017_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="33312" checksum="798A77AC29FDA460" modified="2014-06-11" version="1">MTRREVHEVVGGGSRQNGMTRAGGSDNLLLFSSSTGSRYGYNFDGWKADGVYHYTGEGQQGDQVFKRGNLQLRDHAELGLRPRLFEEAGRSRVRYVGEFRIDEGHPWYAEEAPDRHGDLRKVIVFRLLPLDADAPEPEPVEPEASKPTVKDVPMEEHRAETFQTEPNREPTLAERREADLVSRYVAFLEAAGWKVTRKQITLPDLGHALYTDLFDHGRSELVEAKSSASRNHVRLALGQILDYARHVDHKSRAVLLPSDPGTDLVELLHGSEIACIYESTTPGVFVRVDPGESTPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVJ0</accession>
    <name>A0A010ZVJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3878"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="34817" checksum="5A38D0CFF150EA7B" modified="2014-06-11" version="1">MGADHRVTIYEVAERAQVSISTVSNVLNKPDRVSPATRARVLAAADELGFVPKAQAVSLARRTTGRIGVMAPFTAYGSYLRRLAGVLSAAAELEIDVVVFDHESAASASSPVLASMPIHGRLDGLIVMGLPIEDAIAERLRERRLATVVVDAGSALFSRVMVDDNEGGRLAAAHLRDRGHRRVGYLLEAQASDYESQAIKRLAGFEQVLTAAGGEVVVATSENSVDGARRAASALLGAANRPTAVMAHHDLLAVGVLLAARDRGLRVPADVAVMGFDDGESATAADLTTVRQPFEESGRAALNILLGHVDGSRVRSTTVLDVQVIERSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVY5</accession>
    <name>A0A010ZVY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852801.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860183_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458286" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="7003" checksum="DE73EB49C24C8C5D" modified="2014-06-11" version="1">MVRLRRVALVVVLGGLALLGVDATAARAWVPPEIVCDGVRYTLPLPPDVEPRCEIDQSIPNKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW23</accession>
    <name>A0A010ZW23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570080.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32740" checksum="AB3FB1283836B25B" modified="2014-06-11" version="1">MLNGNSGVVSATTRERILAAARDLGYVPNALARGLVRRDSLTVGILADDFSDASLSRFVVAAQRTIESQGHAALVATTTQGSDGPLRRLQEYRVNGVLVIAPSVEEDESVGEYLRGPIPAVTLNHIPGGGVPAVGSDHRRTGVLAAEHLLALGHRAIGTVTGPTERRVVVSRTSGFRETLHAADVELPDRRVCATEWDARSAAAATHTLLDADPHVTAIFAHNDNMAFGVLAALRARGIPVPQRCSVVGCDDLPLADFAAPPLTTVRVPFDETGARAAELLLARIRGEDTPPRDLLPVQLVVRSSTAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW81</accession>
    <name>A0A010ZW81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4101"/>
    <dbReference type="HOGENOM" id="CLU_035117_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="153"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="27570" checksum="E0045A4C4352D73F" modified="2014-06-11" version="1">MGFVGLGSIGAPMARRLLRWPGGLVVHDVDPRACAAVKGAEVATGVAELASRVGFVSVMVRDDDQVRDVVGQIVASGARPLVAVHSTVAPPTPAALASAAGPRILDAPVSGSVIGADAGTLAFMVGGTAEDFAAAKDVLALMGTRIVHAGPVGAGTAMKLARNLLQFVSFTAAFEAQRLASAAGLDVRALGEVVRHTDAVTGGPGSVLLRGSSEPLTPDDPWTGVFTHVRTLGEKDLGFAVELAAQLDVDVPLARYALAHLGRALGLPEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWA0</accession>
    <name>A0A010ZWA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4122"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="32128" checksum="C19EF5562EF7F7D3" modified="2014-06-11" version="1">MSLSLPTPGPKAPEFGADALIVCESLVRIYQTGPVEVQALQGLDLLVHRGEMVAVVGASGSGKSTLLSILAGLDAPTAGRARVDTWDLLAMTRTDRVTYRRHTVGFVRQQTASNLVSYLTARQMVDLPMTAARVPAATRKARSLELLDTLGVGDCADRRPAELSGGQQQRVAIAVALANRPPVLFADEPTGELDTTTSAEVFAALRHVNHNLGVTVVVVTHDPTVSGHVERTIAIRDGRTSSEVLRRTDGDTLTAEEYAVMDRAGRIQIPRDYRDALALTRRVRLALETDHVTIRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWA3</accession>
    <name>A0A010ZWA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2575"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="22183" checksum="E9FF7D7667FBB004" modified="2014-06-11" version="1">MAYSQGLTRETAQRGERRMVRSAGQRQGPAGNEALIRSLFAEHGRALLAYVTRLTEDRSLAEDIVQETILRAWRNPDVMVNGKGSVRGWLLTVARNIVIDQSRARAARPTEVPEVPYKPPVARDHADNVVNQMVVMEALEQLPPEHRDVLVQIYLKGRTIKEAAEALGVPVGTVKSRTFYALRTLRDGFGGRDLGMVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWB9</accession>
    <name>A0A010ZWB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850856.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2592"/>
    <dbReference type="HOGENOM" id="CLU_000445_39_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="24100" checksum="20CE809D41108695" modified="2014-06-11" version="1">MIRVLVVEDDPIAADAHAAYVERVAGFTVAGKALTAADALREMGRAPIDLVLLDMHLPDMHGLDICRRMRARGHRADVVAVTSARDLNTVRAAVSLGIVQYLIKPFVFATFAEKLEQYAAYRSKLAGGGVLSGQHEVDRALALLHGRGQTGLPKGMSPESLDAVTAALRAADVPVSASEIAEDLGMSRITARRYLEHLTDAGLATRAARYGRAGRPELEYTWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWF1</accession>
    <name>A0A010ZWF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2627"/>
    <dbReference type="HOGENOM" id="CLU_309652_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4062" evidence="1">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="984" mass="109835" checksum="EBCE449DC8E86925" modified="2014-06-11" version="1">MPPVTRVFISSASGTLRPYRQIAIELCYRLGMEPVAMENFYPETAPPLEVCRREVSKSDIFVLLIADRYGDRPPGEDLSYTELEYQWATAKHGTPIVPFIADDRYLAAHVRTHTYAEYRELGDLAKFVEKVRAHHTVKFFNEIETFRNDLYRALEFNRPPDPDRRLTHAQAVTQASWHANRRTLPSAPQPYAIPAYVGGSPFTGRRKELRLLTRWASSAAPVAVVEAIGGTGKSALTWEWFDNHAEAAIPRLAGRFWWSFYDGSASINRFLQQLLGYLTASTAWQVSRIPREELPELVLTELRRRPILLALDGFERLLMAYHQYDPSKVTDTIVEADARADKHSMIDGVGYDFVRALVGTSPSKVIVTTRMAPDALEGPGRSLLPGVYRYRLPGIDDSAVRSLLTKLGVSGGARNIESFFRPLDNHPLLIAIVAGLVRDHRLAPGDFDSWREHQPFSIGAVDLAAKQRHILDAAFQNLDPQTARLLSWLSALSGSVGWRLVQDVNPFGYDSDLSTAEAGAALDAALRDLEARGLLWWDRQANTYDMHPVVRAFSYDRLNATERVTANEQIRDHFAALPPETPNEVTSVEDLQPTITLFRALTGSGNHGRVVSLWNGQLAKPLLVRLGANATVTELLQPYENSTIVILRADLSIALHLAAEHDRGVAVEAGLLAYLLNQPRPELPEIRLSLGRLSTHYRSTGGFALYSKALDFMSQTTAGADVQDLADLLLRRAILAATTGEVEAARSALTRINERSAAERYPWLADDVQYWTLALENWAGNPEVGDRLVDAEQSASDWRMKLRLRLLSFDVSMRHGDLDAALKAAEDVDRLRRVGGQTAISAESAWALAALGRTRDAEATLGQSLARLPRLHPYDRPHQLVARTLSLLGRDEEARQHALQGYRQAWGDGPPFSHRWNLRRAEQLLASLGAPAPVLRASSAATIPHEPRLREWLEARRRTAATQVRPATTPRTTLVDRLQGWLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX81</accession>
    <name>A0A010ZX81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851277.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2909"/>
    <dbReference type="HOGENOM" id="CLU_773206_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="39292" checksum="FB16DDFB41D41C6F" modified="2014-06-11" version="1">MNEVDQAVRWMLTEKADSVSEPERLLAGVHIRIRRRRNRRRALVSAVAVVVLLAAGTVAWSTDRQDRLVPAQRPSAGPGVVPPSPVGVGPMPTNFPAAQVMLDTPGNWLFTSQQDTRPDAWIQVRISRVRLVPSMGLGTYSTIPVGNLRADVYVVPPRPRGGIQERAGSNYKGGPYLELTYFHRAFGVWVQISASHRAETRPLGVTPDDLAGIARGITAQETPISDQLRFATAPPGLTVGGALTGPRRSIYEFLEPDGDYEAMRPEPGSLDLHGVVTVRVQAGHDHDNPIRVRTFEAGRWTVTKYRRLGTADGPSYLMTIDDRRSIIVEVDERARFTDEEMTHFIGGISLGPDFACCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXH6</accession>
    <name>A0A010ZXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851417.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3011"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="366" mass="39552" checksum="D34479739F20C6AD" modified="2014-06-11" version="1">MTPTALVVGASIAGISSAYWLHRAGYSVTVVERAPALRDGGYKVDVRGAALEVISRMGLLDEVRALRTDVRSGTVVDATGRRVASMDGDTFGGRTHGDAELLRGDLTRLLHRHTADDVEYRFGEALTALPEGYDLIVGADGLHSATRALAFGPEADYVHDLGYRIAIATVPNHLGLDREEVTYVGPGRTTLVYSTAGDATAKAMFLYEGDERDLRAAYADQGWEVPRLLDGVDRADDVYSDALCQVKMDGWHRGPVVLVGDAAWCASPASGQGTSLALVGAYVLGAELAAGHGPEAYERRMRPFVERNQALGPANIKRMVLHSPGQVRTSMRMLAVMDRLPFKEWMLGKVMQPLHRAANAIELPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZG3</accession>
    <name>A0A010ZZG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3774"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="592" mass="61947" checksum="BE2D7EE9A97F573B" modified="2014-06-11" version="1">MREPLRLLARLASPHRRRLLGLLAVGAGQGACAVAAPWLVGVAIDTGIPRLRNSDAAPLAAIAVAIVGSAVAAGFLQARWFRGAGTIGQAIVLALRTETFHALRRLSVAYHERVRAGDVIARQTADTEAVTALLGTPLATVAQSAFTLVFTTAAMLLLDVELAAVTLAALLPLAALLAWQARQLGPAFRAQRAASAESTAQLVEALNGIRVVQAFGRQGRNDEAFASSTGRLRSATTRILTLRGILWPVLELVFSLAALVVVVVGGLRVAEGSLRVGVLAAFLLYVAQFFAPVTALPLVFDSLQAALAGLDRIGAILAAEPRVAEAARPVPLGRRPRGEVVFEDVSFSYRAGSASPEIAGLSLRLAAGRTVALLGATGAGKSTVAKLVARFYDPESGRITLDGIDVRALSDADLRRAVLLITQEGFLFAGSVADNIAVGRPDATRAEIEAAARMAGADRFVESLPQGYDTDVHSRGTRFSAGQRQLIAFARAFLADPAVLVLDEATAALDIPTERAMRTALRTLLTGRTALVIAHRLSTVETVDRVLVVAEGRIVDDGPPAALLARGTGAFADLHADGHGRPLDGSPAAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZR7</accession>
    <name>A0A010ZZR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852654.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3891"/>
    <dbReference type="HOGENOM" id="CLU_2218697_0_0_11"/>
    <dbReference type="OrthoDB" id="2069270at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="106" mass="11197" checksum="94B789A75E264ECD" modified="2014-06-11" version="1">MDATESTVARIWTDLGLLPTSADDDFFALGGQSLTLVRFLARVREELGLELPVDALFESDLTVRAAANVVTTARLDSADADELARALAELDGMSEAELSALLAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A002</accession>
    <name>A0A011A002_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852740.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3966"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458452" evidence="1">
        <location>
            <begin position="28"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="33"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="36029" checksum="CD0974D1EF124AE2" modified="2014-06-11" version="1">MNKRRVLGVLTAVALALAAAGCGDSGSSDSVSVSLITKNSTNPFFVTMQDGAKKAAADNGVKLTLAAGKEDGDEQTQVQAIEDAIARGDKGILITPNGPGVNSAIKKARDAGLYVIALDTPPDPADTVDITFATDNFRAGELIGKWTAVQLAGKPATIALLDLFNDKIVSVDYNRDQGFLTGMGIPTGDKMKNGDEAKTGRYSGGTYQIVCNEPTQGAEDGGRTAMERCLTKNPGINVVYTLNEPAAVGAQKALKAAGITNALVVSVDGGCDGVKQVKDGIINATSQQYPVKMAELGVKAIKDIATDGKKPSVTGGKDFFDTGVALVTDKPADGVESIDTTKGAELCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0E9</accession>
    <name>A0A011A0E9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853076.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4148"/>
    <dbReference type="HOGENOM" id="CLU_066586_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="36731" checksum="269AF938CF1F1E05" modified="2014-06-11" version="1">MESLIGAETLWIPIDDTSAVGAARRMATGLAGRAGFDEARTGELAIAVTELAGNLHRHAHHGAVALRLTRPYLSDSDTADPAVEVVALDAGPGLEDFEAHLRDGYSTGGTLGVGLGAVTRLASTFDAWSQPGRGTVVAARFAAPRRPLTRIGQPAQPGGERAAGLTRPMAGESACGDAYAVRRTADGVVAVLCDGLGHGPLAARAAQRAVEVFLDTADEDVTALVTRLHRELKPTRGAAVGVVRHDVSRGLVQFAGLGNIAGAVLWAGERGRHLTSMPGIAGHQARTIRSFDYPAAENALIVLHTDGLNSRWSFDGQWGLAGHDPLVIASVLLRDAGTRRDDAGVLVLKCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAF3</accession>
    <name>A0A011AAF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847335.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2463883_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG78996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="88" mass="9675" checksum="246EB987BA8B32D5" modified="2014-06-11" version="1">MATAAAEKRRLLARLGEVDRQAASLDNLRQQIRDAVAEVSAEIAGSATGSDRRILDLLQMNLEELDRSILLMRNAVEAGREFVAQVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB10</accession>
    <name>A0A011AB10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2971815_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="58" mass="6398" checksum="19DFD5FC2998BA87" modified="2014-06-11" version="1">MRALSTNEPSEPGLSRAERRAAAKGRKGSVESPRAVELPGRGKNVVHDRSRYAIRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC86</accession>
    <name>A0A011AC86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.685"/>
    <dbReference type="HOGENOM" id="CLU_009834_15_3_11"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="318"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="497"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="718" mass="75157" checksum="E0F7F83BED390F1E" modified="2014-06-11" version="1">MSIRWDRAEDGIVTLTLDAPNASANTMDAAFEAALGETVDRLVREKDSITGVILTSAKKTFFAGGNLDALIQASPESRDQLLTTVDDIKRRLRTIETLGVPVVAAINGAALGGGLEIALAAHHRIALDTPGTKLGFPEVTLGLLPGAGGVVRSVRLLGLVTALTQLLLQGQQLRASAAKDLGLVHEVVTDPADLLVKARAWIAANPQATQPYDAKGYKVPGGSPNSPSLAGFLPALPANLRKQLKGAHLPAPHHILCAAVEGLLVDIDTAFVIEGRYFADLAAGQTSTNMIQAFWFDLNRINGGGSRPADVPASKPTKVGVLGAGMMGAGIAYVTAKAGIDVVLRDVSAEAAERGKAYSRKILDKQIARGRSTEAKRDALLGRIHATADVADLAGCDFVIEAVFEDTALKHTVLAEAAAAAPDALITSNTSTLPITELQQGAGLPDLVGVHFFSPVDKMPLIELIVGADTSPEAVAKAYDYTRAIGKTPIVVKDSRGFFTSRVFGTMVMEGAAMLGEGLPPMSVERAALQSGFPAGPLTLLDEVTLTLPLKIEEQGGGAAAHPGLKVLSTLVREHDRTGKASGKGFFDWEPTKTVWPGLAEAFPPNVDGLAPGAGNDPIRFRDAQDRLLFIMAVETARCFEEGVLTSVEDANIGSIMGIGFPPGLGGVAQFVDQYDGGVAGFVARADELADKFGERFRPPALLRDRAVAAGSLREALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACU2</accession>
    <name>A0A011ACU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848649.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.904"/>
    <dbReference type="HOGENOM" id="CLU_048112_0_0_11"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="235"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="466" mass="51076" checksum="319A14B893991EE1" modified="2014-06-11" version="1">MSATTYDVRIWKTDIYRGKRKTTYYVRWSVAGQPKKEPFSSAALAESYRSDLVAAARKGEAFHIASGLPVSMRRAEHDMPWYTFACSYADDAWPRVAATTRRTHAEALTAITLALLTTTRGKPDGPLLRRALCRWGFNTTRRGAPDTPNDVRAALRWVTDHTRPVSALAEPPILRAVLSSFTNRLDGKPAAPSVINRKKIVLGGALGYAVEHEILTTNPLPALKWRSPRPAHTVDKRAVVNPVQARTLLRAVAAQPGSGPRLLGYFATLYYAGLRPEEAAALTTTNLALPITGWGELHLTDARPHAGNEWTDHHGDRDQRHLKHRAVRESRTVPCPPELNRILRDHLDQFGTGDNGHLFVGARNPRELPKITAARIWTAARAEAFTPEAAAGPLARRPYDLRHAAVSTWLNAGIGPAQVAAWAGHSVDVLLRTYAHCLDGAATVHQQRLNTALGHPETTSPSAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE95</accession>
    <name>A0A011AE95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043514_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="433" mass="48194" checksum="4338A29183826245" modified="2014-06-11" version="1">MPAAEWVLLGGLVGLAVVIRYACRSYWTTDLDVFGEWYDQLQREGLKAPVGNYNAPFLYLLEVASWFPGPALMKIKLIFAAFDVVLAYYVYRTVALKWTGWRIPATAALVAAFMPTVVLNASMYGQCDSIWGAFCVAALYYVLKNNDWAAVAMVATAWAFKPQAVFVFPVFLLAVLAGRVRWRAVLVFPLVYLAWDIPALLAGRDAIELLTIYSNQLDDPSALRRGGPTVYQYLHVNVALGVLRNLGYLFAAALSLGVCYVLIATRATLDRTRWLTAGAFFAIAIPWLLPAMHERYFFLADVLTLILAFYLPRLWYVPLIVQASSFFSYLPFMFSKAPVGPMIDRRLLATLMLVALLVTGHRLLSGVVVKATERPEDDVNFLPEPAVSLVENDSHNDRRGPKDGASDREAGAVDHDGQQRPDPDRAVREAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEP7</accession>
    <name>A0A011AEP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">CryarDRAFT_1591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849433.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1563"/>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_11"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="54" mass="6573" checksum="388AE0CFC8F08BFD" modified="2014-06-11" version="1">MARNEIRPIIKLRSTAGTGYTYVTRKNRRNDPNRLTLRKYDPVVKRHVEFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFT0</accession>
    <name>A0A011AFT0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850007.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1945"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="32843" checksum="52ECBB34B48CC85D" modified="2014-06-11" version="1">MSLTVGVDVGGTKVLAGVVTPDGEVLATVRRPTPSQDVNDTARVIAEVVRELDEDFSIEAVGVGAAGWIDASRSVVLHAPNLAWRREPLRDRIQERVDLPVVVENDANAAAWAEYRFGAGQDQHHLILITVGTGIGGGAVVNGEIYRGHFGMAAEYGHTRAVPDGHPCGCGASGCWEQYASGKALVRFAKQRAREDASAARVLLEMAGGHADHIDGPMVTRAAQAGDAAALASFTELGDWLGWGMADLVSGWDPQCIILGGGVAEAGDLLSVPARETYAKVTALRGRTEVAEVRIAGLGNKAGLIGAADLARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHH3</accession>
    <name>A0A011AHH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2549"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023851">
        <property type="entry name" value="Tscrpt_reg_TetR-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03968">
        <property type="entry name" value="mycofact_TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="24151" checksum="9410BCD09F64B4BE" modified="2014-06-11" version="1">MANDPVPAVRMGRPPATSHDELERIGLELFTTRGFEETTIDEIAGAAGISRRTFFRYYTSKNDLVWGDFDAELSRLRERLAATPPSVPMMAALREAVVAFNRVDAAHVALHRRRMALILGVPSLFAHSTLRFTGWRDVIAEFVGVRVGRPSGALLPQLVAHAALGCAIAAYTDWLHHEDADLEPLLDEAIAELATGFAGHEKRAGSETAAGFTDHGTAPADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIB7</accession>
    <name>A0A011AIB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2812"/>
    <dbReference type="HOGENOM" id="CLU_099797_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="20962" checksum="CC3152DF83D5ED5D" modified="2014-06-11" version="1">MTVRRGAARRTELLDALVELLLAEGFASFTLDDLAARLHCSKRTLYALAGSKEQLVRSAVVHFFRNATAAVEQATGDVPDPAGRIAVYLSSVADALRPASAAFIDDVAAFAPAAEIYERNTRAAAARIRAFVDEGVAAGAFRDVHTGFVADVVASTMVRIQRREVAAATGLTDAEAYTELAALVTTGLRVSEPAGRGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIG8</accession>
    <name>A0A011AIG8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">CryarDRAFT_2906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851228.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2868"/>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_11"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="543" mass="59338" checksum="FCE7B26B7FC81FFE" modified="2014-06-11" version="1">MSPKTVEIDATPEWAAAAEHAARLRDTHLRDLFAADADRAGRLTVEAAGLVADYSKHRVDAAALEALFALARAADVEGHRDAMLRGEKINTTEDRAVLHTALRAPRDASIVVDGEDVVPLVHEVLDRMAAFSDRVRGGEWTGSTGRRIRTVVNIGIGGSDLGPRMAYQALEPYADPEIACRFVSNVDGDDLASNLKGLDAEQTLFIVASKTFTTLETMTNARAARDWLVDQLGEKADVAKHFVAVSTNLGEVEKFGIDPANTFGFWDWVGGRYSFDSAIGLSLMVAIGPSGFRELLEGMRAVDEHFASAPLEQNLPVIMGVLGVWYREFFDAQSHAVLPYAHYLSRFTDYLQQLDMESNGKRVRRDGTPVGYQTGPIVWGTPGTNGQHAYYQLIHQGTTLIPADFIAFLHPADEVGDQHDLLTANVLAQAEALAFGKTAEQVAAEGVAPELVPHRTFPGNHPSTTFVVEKLTPRTLGALVALYEHKVFVQGAIWQINSFDQWGVELGKALAQRIVPELSTDSELSHDSSTNALIRRYRAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJL5</accession>
    <name>A0A011AJL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164340_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="26652" checksum="E1A045ADBCDC98FA" modified="2014-06-11" version="1">MPMEGEHDWSVLGELPHLETLWLDIPGLKPIPDLERLTAIRRLILEWHPGQEQLLMSIPPLAELGIVRWGLADLTALTTHLTTLQQLHLTSARRITSLGDLEPATTLESLRLTYCTRLNTLEPLSQLTGLRRLAIDRCGKLSDFSALGTLRNLRALELANTTIDDLDALRGLPDLEYLSIDGNVRSGDLSPLLALPALRILFFQNRKHYSHRVTEIQEALGLDPAAYPEPGLRSEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK25</accession>
    <name>A0A011AK25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="23203" checksum="B9F06590150E0B69" modified="2014-06-11" version="1">MTISRDRLRAGEPDAFGDLFNEFAQRVYNYAYRLLSDWSAAEEVVSMTFLEAWRRRDRIEPTGASLLPWLLGIATNHARDFARARRRYRAALSRLPPPTAEPDFSEAVASRIDDDALLPAAQAALDGLRRAEREVVALCVDAELDYASAAEALGIPVGTVRSRLSRARAKLRAQLERSDATPPTGLRPAGHPPLAEPAAGPTPTGRKHRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALH8</accession>
    <name>A0A011ALH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852686.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_11"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28987" checksum="1E205EFFED614114" modified="2014-06-11" version="1">MRRVLRPLQWVWLLVVVLLVWELLTRTVTRSLFVPPVSEILRTFGDSWFAATPSTLFLSEEFRTNVLPSIGRIAAGYAIASVAGICGGILLGVWRPAGAFFNPLIRLGMSVPVTALLPLAIVVFGITNSMNVFLIALGCLWPILINAYDGARGIDGTMTLTARSMQLSRRRYFLNVLLPGASPAIVAGMRVSVGTAMVLMVVSELYAATSGLGYYLTQQQRLFRFPQLWSAILLIALIGILANAAFAALERSALRWHHAARGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALX5</accession>
    <name>A0A011ALX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853051.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081768_0_0_11"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="29005" checksum="F302A505FEDE98D1" modified="2014-06-11" version="1">MTVRVGLVGAGPWATSFTGPLLAAGPGTSLAAVWARRPEAARTLGVPVAGSFDELLGTCDAVAFAVPPDVQAELAPRAAAAGKHLLLEKPVAFGLEAAERVAAAADEAGVVTQLMLTNRWSAAVPEFVERVRAAGPRVLRAEFVGSGAMPGSFFATPWRQPEAALQDVGPHVFDLLESAAGPARVVHARRAGAVTAVTFEHASGAVSSAVLSIATPGAHGPMKCEAITDAGRVELADPGAEPPATVQQRIAATFAEAVTSGKSPSPDVHRGVELQRLLAAAEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFU0</accession>
    <name>A0A010YFU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein, UBP type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163943_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="85" mass="9299" checksum="3D6F3EF181C78017" modified="2014-06-11" version="1">MAICTHIAESKETAPRANGCEECLKVGGRWVHLRTCQECGHVGCCDSSPGKHASGHFHDEKHPVVQSAEPGESWKWCFVDEVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGC9</accession>
    <name>A0A010YGC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="8" type="ORF">CryarDRAFT_0312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.297"/>
    <dbReference type="HOGENOM" id="CLU_060552_2_0_11"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="68"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="25255" checksum="55C3612E8A4FA4B8" modified="2014-06-11" version="1">MGFADTDRAESDGSQVLGCEERHSTNGRAVDRIQADPVVDDELIVLLSDDGRTIGTAPKLASHHRETPLHSAFSSYVFDGEGRFLLTRRALSKKTWPGVWTNSCCGHPAPGEDAVSAVRRRLNHELGLSVTAEEIVPLLPDFRYRAELDGIVENEICPVFGVRVDAEPVPNPDEVEEYRWVDWPTFVTEGLAGRSEVGLSPWALLQLAQLEDHPVVAALRKPSPSGEAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGU2</accession>
    <name>A0A010YGU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057336_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="29319" checksum="CB6DF49D4A143812" modified="2014-06-11" version="1">MFKKLSAMFGGGASVDTVLASPHTRPGDVLRGEVRISGGNVEMVVDRVELELVAKVEVEGESAGGDDYEYNTMLPFQRLHLGHRFSLQPGARHAVPFELAVPWETPVTTVNGQPLHGMRLGVRTELELAGSLDKGDMDPIQVNPLPAQARLLDAFSRLGFQFKGADLERGTLYGSRLPFYQEIEYYPAHQYAGTINELEVTFISGPQSMDVLLELDKRGGFLTSGSDAYNRFTVQYAGAEQLNWEQWLHEHLQILTQRRGMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHQ1</accession>
    <name>A0A010YHQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5-thioribose kinase</fullName>
            <ecNumber evidence="3">2.7.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.100" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569716.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.820"/>
    <dbReference type="HOGENOM" id="CLU_033681_0_0_11"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046522">
        <property type="term" value="F:S-methyl-5-thioribose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009212">
        <property type="entry name" value="Methylthioribose_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031134">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01767">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="4">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="402" mass="43988" checksum="75E7A0B34ABC8271" modified="2014-06-11" version="1">MDLLDVESVPDYVASLPDLASRVGTVSQVREVGDGNLNLVFIVEGSAGSLVLKQSLPYVRTDPSWPMTRERSSREAYVLASHQAIDPAHVPGLLFYDETRYVLAIEDLSDHRVWRTVLNERTEATDDDELAAAALGEYIANVGFGTSVFGVGSAAHKQAVARAINPELCEITEDLVLTEPFVDHDHNVVHPSNEADVAELAGDPDVKHAAGRAKFAFMTRAESLLHGDLHTGSVFVRFGDDPSVRAFDSEFGFYGPLGFDLGMLWANYVLAAARAVAQGQDSRARRLLGLGRVTWGSFERTYRDRWPSRQDPRVYGDAVLESLLTQVWTDAVTYAGAEVARRVIGFAKVADIETLPEDQRVQAARRALRASRVLITHTLHGRPDPDVLADLTSEPLGLSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJL8</accession>
    <name>A0A010YJL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849314.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1482"/>
    <dbReference type="HOGENOM" id="CLU_067442_2_0_11"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="25578" checksum="4825FF8D976A12F1" modified="2014-06-11" version="1">MTDPVFLVDELPPVGPAVLDGPEGRHAATVRRLGPGETLLLADGVGGRASCVVVAADRDSLRLDVRTAERVPRPTPTVTVVQALPKGDRGEAAVEMMTEAGADTIVPWSASRSVTRWKEARGDKALARWRSTAREAAKQSRRLWLPEVADLASTADVRKLLSVHDAAFVLHEDATAPLAGTSPAAEIGTIALVVGPEGGIAPDELESFVQVGAVPVRLGPTVLRTSTAGVAALAVVNALTSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL28</accession>
    <name>A0A010YL28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850069.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2000"/>
    <dbReference type="HOGENOM" id="CLU_008681_4_0_11"/>
    <dbReference type="OrthoDB" id="607330at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="35972" checksum="10AEECAC75ADB1E6" modified="2014-06-11" version="1">MHLSDRQPEVAPARLVAELVPPPRFADARFDTYRPDPNEPSQAAALAAVRAFAERLSAPPPRKGLFRRAARAPEGRPGIYLDGGFGVGKTHLLTSLWHAAPKPAGYGTFVELTHLVGALGFAGTVDALGTLRLLCVDEFELDDPGDTVLVSSLLTRLVERGVALAATSNTLPDKLGEGRFAAEDFLREIQALSARFDAVRVDGPDYRHRDAAEAPEPLAESVVAERVAAHPAATVDDWSTLLAHLATLHPSRYGALLDGVEAVGLTGLTPVPDQNTALRVVVLVDRLYDRSLPVFASGTPVDEIFPPEMLAGGYRKKYLRALSRLTALAREGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN03</accession>
    <name>A0A010YN03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850956.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2664"/>
    <dbReference type="HOGENOM" id="CLU_410347_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="437"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="669" mass="69760" checksum="72DC0770C7926141" modified="2014-06-11" version="1">MSPALGSVGFATLFGLAAVAGRLTILDGTNLSLVWPAAGVSIVWFVARRATVLDWALLVGVTLAVNLVTHAPPVLAAGFAVANVVQISVFLAVLGRLRPDWRRGGADPLTTLSDLWRMIAATVAGTFAGALIGPTLANWYAGSWNWLGEVVWLTRNVSSILAIGILGLLFLGGRTGERLSGWRHAELVALAACSAAAYALAFAQAHGLPLAFPLLLVTVWAGTRFPATLVALHGVTVGTAAVMFTLHGQGPFATVESYPGRALMAQAFVAMVAVLGTVLALGRDERRVLTGELAETAAASAAQAELLTTIVDSMSDALMVVGADGKILLRNPAALELWRGVGRRPEHVGASGEFEFGEPGGGPIPVSDLPHAHALAGVTVVDRDVVVRQRSTGTERVLQVSAAPLPAEDAGPRAVVVYHDVTVDRRHRDELTAFAGVVAHDLLNPLTTVEGWTEALADTLGDDPDARDCITRIRRGSTRMRHLINDLLGYTTARDGALTSARVPLAELVGEIASARIDQALAASALPPRFTVGALHDVEADPVLTRQLLENLLGNAIKYTARGVVPHVTVTTDLVDDRVRLTIGDNGIGIPPGQHEAIFADFHRAHRDAGYTGTGLGLAICARIVERHGGTIAASDNPGGAGSRFVLTLPAATTSAPARESAGVDSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNI6</accession>
    <name>A0A010YNI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851151.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2811"/>
    <dbReference type="HOGENOM" id="CLU_018204_3_5_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="226"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="40007" checksum="074278D6CA951512" modified="2014-06-11" version="1">MPVDRLLPSTEAADLIELTRDIADKELAPRVDAHERAETYPDGLFATLGAAGLLGLPYPEEFGGGGQPYEVYLQVLEELAARWAAVAVATSVHGLSCYPLATFGSREQQERWLPEALGGSLVGGYSLSEPHAGSDAAALTCRADAADGGYAVTGQKAWITHGGKADFYALFVRAPAGITCFHAPGAVEGLTFGAPEEKMGLHAIPTTAAFWDGAFLSADRRVGTEGQGLQIAFSALDSGRLGIAACATGLAQAALDTATAYANERTTFGRKIIDHQGLGFLLADMAAAVDSARATYLDAARRRDAGRPYGRQASVAKLVATDAAMKVTTDAVQVLGGYGYTRDFPVERYMREAKIMQIFEGTNQIQRLVISRSLAVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPT7</accession>
    <name>A0A010YPT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3304"/>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_11"/>
    <dbReference type="OrthoDB" id="1128314at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="5">
        <location>
            <begin position="294"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="532" mass="58794" checksum="E87AFDBE7E7180CF" modified="2014-06-11" version="1">MKRSWLVVQRCEAAQELLPHLAGIEIDEVVGGESGVLLAAGVRGQRAECPGCTASSTRVHSRYRRRIADAPTAGRSTQIWLRVRRFFCENTACEKKTFVEQVAGLTRRWARCTDSLRRMLTAVGLALAGRAGARLTAVLGMPVSRHSLLRLVRGLPDPPVSPVSPVTVLGVDDYAVKRGHHYGTVLVDCQTGKAIDLLLGRDADPLAEWLQAHPKPVVICRDRATAYAEGAATGAPEAQQVADRFHLWQNLATAVERTVIGHKRCLEEPAVPAAETSRSPATEPTGAMADRRKANHALVHDLVAQGASFRQIAEHLGWSQRTVARYAHAKAWQELMVGQKPRPSLLDPFIPYLRERIDQGCLRATRLHREVTTQGFTGGYGIVRAFVEQHRMKPDLERVRRPASVREVTGWICRHPDNLVEHDSQRLQAILERCPELNTAAELVRSFADMLTHLHGHRLGTWIASAQASAPSPIARFATSLTNDLAAVTAGLSQPHNSGPVEGNVNRIKMIKRQMYGRARFDLLRKRVLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQL2</accession>
    <name>A0A010YQL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-type ATPase, translocating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3643"/>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="880" mass="92853" checksum="79D57545F453E3CF" modified="2014-06-11" version="1">MNVIEETHSPVIVGDPRENMQSLLRDLRARPGGLSAEEAARRRVQYGPNALPTQGGPSWIRALTRQLVHPLALLLWGAAVLAGLSGTPTLAIAIVAVVLLNAALAFWQEQQAERSVEALAAFLPPHARVLRDGHVVELDAVEIVPGDVLLVDEGATVPADARLLDGAVEVDMSALTGESVPVIRTAGETDAVAQLLHVPDAVFRGTLCTGGTGHAVVFATGAATEIGRIATLSHGVERTDSPLERQVRRVAWLIAAVAVGVGLAFLPLGLVAGLSLPAALVFAVGLLVANVPEGLLPTITLALAVGVRSLARAGAVVKRLSAVETLGSTTVICTDKTGTLTANRMQVHQLWTPHADIRDAADIPPGDGHVAALAEALARCTDATLDGEHDTGDPTELALLRFARIHVPARGALRITVHRFDPRLRRMSTVDRGTERREVSGKGAPEAVLPLCRLSDAERATAESVVAQLAGRGLRVLAVAHRPLGDTVPADRDAVERDLRLCGLVGLLDPPRPSVAPAVRTCHRAGLRVHVVTGDSPLTGAAIARSVGIGDDDSAVITGDELAAMTDEQLAGRLQTDGEVVFARSTPEDKLRIADALSRGGEVVAMTGDGVNDAPALRRADIGIAMGKSGTDVAREAATMVLTDDDFATIVRAVEAGRRVYDNVRKFILYIFAHAVPEVVPFLLFALSGGAIPLPLTVLQILAIDLGTETLPALALGREPAEPGLMDRPPRRRSEGVVTRRMLIRAWAVLGPVSAALVLLAFFSVLWRAGWTPGADVGHHTYLQATTATFAGIVACQIGTAFASRTERVSLFTVGLFTNRLLLIGVVFEVVFTAALVYLPPLQAVFGTAALDGWTVALLCTFPPVVWGADELYRWLVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQQ3</accession>
    <name>A0A010YQQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852405.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3692"/>
    <dbReference type="HOGENOM" id="CLU_046113_2_2_11"/>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29518" checksum="17DE994F620419A0" modified="2014-06-11" version="1">MSTTLAAPEASDTPVRRRRRRVPEITYSVLVFVGLLVVWQFVVKVFDVSDILVPAPTAVADSLVDGFRDGSLITHSVVTLKEILIGFGIAVGSALVSAVLITQFRPVERVLFPLLILTQTIPKVAMAPLLIVWFGIGISSKVLTVALIAFFPLLINAVLGFRSAAHEQVEMLRSFGASRVQVMRHLQIPSALPHIFAGLEVAVILSVTGAVVAEFVGSSEGLGYLIQATNFTLDVARTFAVIVVLSAIGIALHAIVVQLGKWLIFWTSTPDAAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQZ8</accession>
    <name>A0A010YQZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein, terpene synthase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852539.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042538_4_2_11"/>
    <dbReference type="OrthoDB" id="1869158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="345" mass="38164" checksum="6F7F26904C01A46C" modified="2014-06-11" version="1">MPRDPVPALYCPLPTRMHPESGPIGRRSVAWLERFGLLDDDRTRERIRATRPAEWACRIAPGGTGAGLQLVSDWTHLGFVIDDTRFDAGPIADRPGRLIPLMMRLMHALDHPEAPADDDPFAAAFRNLSARARAGAPAAVVRRWADGNLEWFFSVACLTAHRVAGTMPTLTEYLNLGPRDRAMRLTGSLIELAEGSVLTDADREEPTVRAVTQAANLLVTIGNDLFSFRKEADDDVLESNIVGVIRHRDGGTAEAALARTVELHDRVMCLYLGLRAQLDEDGSSTVRRHLTRLDHLIRGNLEWSVRVPRYGTGSASPWAETPADGRAAAPHLVPIDWWWDQLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR03</accession>
    <name>A0A010YR03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183103_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7286" checksum="09A7CDDBD97012F4" modified="2014-06-11" version="1">MQRQVVLVVGMVLLVVGAQGAVRLIADHDDGGLLGWVPGGFWVRAACYALAVVAGVGLAARGAKARATDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR28</accession>
    <name>A0A010YR28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852580.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3817"/>
    <dbReference type="HOGENOM" id="CLU_052806_1_0_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="33837" checksum="104415153B51AF9E" modified="2014-06-11" version="1">MDERSELLTIGQLADRTGIPVRTLRFWSDEGAVPPASRSAGGYRLYDAGGAARAELVRTLRELSLGLDEVVGVLDGRATLAAVADTHVAAIDAQIRALKVSRAVLSTVSKRNSTAQEAALMNRLARISATERLRIIDDFKADVFGGLDLRPEVRDRLRDLRIELPDEPTPDQVDAWIELAELVQDPGFRTRMRTFLELSVPTPAGEPKPPGARVFWARQVVEQVREARERGVAPGTPAAAGFVAATFSDAEPLAAVLTCVEAGIDARAETYRVLVSRVRGQHAADDAGADLDWLAHALRAVVAREAPRRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRI0</accession>
    <name>A0A010YRI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570664.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3969"/>
    <dbReference type="HOGENOM" id="CLU_046066_3_3_11"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="261" mass="27962" checksum="DFDF15A333636E82" modified="2014-06-11" version="1">MPLFDQISATLTGVADDRPPVVLVHGLTYDRRQWGPLTRELDALDPGRRTFALDLPGHGQSPPRDAYGSDETAEVLHRAITAAGLDAPVVVGHSLGGILATVYAARYPTRGVLNLDQPLRLGRFGAVVRDVEPVLRGPDWRAVWDRFVAGMGTDGLAPDARALARDASAPRADLLLGYWAEILGSTDEEIDARRARELAEIAARGVPYVLVTSTEPEVRLPGVEQVVLPGGGHFPHLAHPRAVAELLAQSVQRVGPPGAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRJ8</accession>
    <name>A0A010YRJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852790.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="44021" checksum="D7085C0C8D30E1F0" modified="2014-06-11" version="1">MSLDHADVVALLDRQTGILEQITTGVTLPGVLTGIATTFEDLVPGCCCSVLLVDPDAATLRHGAAPSLPAEYLNAIDGLTIGASAGSCGTAAYTGRPVVAVDVRVDARWERYRSLADRFGLRACWSTPIRGRDGVTGTFAVYHPAPHRPTSRERHLVERLTHLAAVAIDHDGAERERRRRVDAELAQQAAEAADRAKTDFVAALGHELRTPLQAITGFTELLGTLELDRDRRAAALEHIGAAADHILAIVDDVLDVARIEANALPLTVAPVALAPVVDDVLAMLDPLASAERVRLHVLAGRPADLLADERRLRQVLLNLVGNAVRYNRADGVVRIGWALDGGRAAITVDDTGPGLAPEFLDRLFVPFDRLGADSEEGVGLGLPLARGLTEAMGGTLQVCSEIGEGTKVTVVLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRM5</accession>
    <name>A0A010YRM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4037"/>
    <dbReference type="HOGENOM" id="CLU_626647_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="426" mass="45364" checksum="2B88097611ADB7FB" modified="2014-06-11" version="1">MSANDPGRRAGGRDRAAGLVFAAAVGALAGASVVRRRRGRAALAGAVALAATEAVARTRQQPGEVPPWWSRVVMSGAVAAPVGRLGGRLTDAGPVAVGTVAGAAAGALGLRPQKVALGPVVGAAVGWAWRAAGGREPGAVAATAVVGFRALSALLFRDAQVSLLAEGVPAGQLPFVVPLEARTRYVGTGYVRDLAAVIGGEYRADAPDVGIVASLDDLSGPEFDPADVEPLVREFYEHTTRFRLDIVPEWRLWVRPGYLLYRTLVARPVGQANVPMNQRETVRGVRSRIDTITPDGTDVIGVRGWIRSFADTDEPIYVGIYTTYRHEGRGYVSVGFPVPQGSFTATLEPRSRPDRGLVLTSRSPRPHPGHYLTYIDPTTRALTTLSVAGFAERLDVYSAGGELRAEHAFSLYGFPFLVLHYTIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRW5</accession>
    <name>A0A010YRW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyribodipyrimidine photolyase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4135"/>
    <dbReference type="HOGENOM" id="CLU_031632_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="488" mass="55753" checksum="2FCC7603A4FFAC43" modified="2014-06-11" version="1">MRVERRWLFADQLGPHFLDAPDQPVLLVESKGVFRRRVFHRQKAHLVLSALRHREAEGDDVRLVRAETYAEALTEPVSVCHPTSRAARAFVQRLDGVEMLPPRGFVTAPPDFVAWADGKKQLRLEDFYRFARRQHEVLMDGDEPAGGQWNYDADNREPPPRGTSTLDVPPPPEIREDAIDDEVRADLDRWQHDEGIEFVGNDGPRLFPVTRTEALARLRHFVEHRLAAFGPYEDAMLANDPLMAHSLLSAAINLGLLDPREVVERAERAYRSGAAPLAGVEGFTRQILGWRDFVWHLYWYFEPRYRTANALDARRELPKWFASLDADAVEARCLSDVLAGVRDRGWVHHIPRLMVLGNYAMQRGWRPGAVSDWFHRCFVDGYEWVMTANVIGMSQFADGGRMSTKPYAAGGAYINRMSDYCGGCRYDPKHRTGDDACPYTAGYWSFLARHEEALEGNHRMRQPLRGLRRLDDLDALVEQERARGSRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVA2</accession>
    <name>A0A010YVA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriophytochrome (Light-regulated signal transduction histidine kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569534.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.96"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="189"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="419" mass="45215" checksum="D8A5FD2F9DA6370A" modified="2014-06-11" version="1">MAGRIDRDALIAPYDVVGHPPAPDLTALAELAADISGTPTALVNLMGETIQHSVAGYGRAPGVCDRADSMCNLVLDEPGQVVVNDTRADPRFADSPFVTGERANFRFYAATHLRNPQGLVLGTLCVFDDEARSLDDRRIRGLGLLARQVDDALELRRRTTKLVDAVAELAEVRAELTRSNEALHAFAGQVSHDLRNPLTAINGFLEELQYNVPHDTPSSEYVARALSSTHRMSDLITDLLGFAKLGGELRREPVAVRHLVEEVRHDLAPALSAVGARLDVGPLPTVRVDATQIRAVLQNLISNAAKYRHPERTPLIAVHSARQDHAWRIEVVDNGIGVPRDRREEAFSPLSRVHDPHDSSAEGAGIGLATARRIITAHGGQIGLDASPSGGTVAWFTLPDPTDGPSFASATPPRSARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW27</accession>
    <name>A0A010YW27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.358"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="248"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="411" mass="45097" checksum="22537A20FBDEBF9E" modified="2014-06-11" version="1">MTATALPAPSERAVELRERMVDFLRDHVLPAEARYVEARRGAGPDDHEVPPVVEELKETAKRLGLWNLFLPAESGLTQLEYAPIAELSGWVNDLAPEAINCQAPDTGNMELLHLLGTDEQKKQWLEPLLAGQIRSAFAMTEPDVASSDATNISTRIVRDGDEYVINGRKWWTSGAADSRCAFFILMGKTDPDAPSHRQQTMVLVPREMPGVRIVRDHSVLGHWDQHGHPEVEFVDVRVPVTNVIGEEGGGFAAAQARLGPGRIHHCMRALGAAERALALMVARAQSRVAFGRPLAEQGVVQQQIAESRLEIEQARVICHLACATIDAEGNKAARNLVSLAKVAVPRAATNVIDRAIQVHGGAGVSETTPLAWMYAWHRAMRLFDGPDEVHLRSIAKAELRTEPVLPPAWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWH1</accession>
    <name>A0A010YWH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848206.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.525"/>
    <dbReference type="HOGENOM" id="CLU_045231_0_0_11"/>
    <dbReference type="OrthoDB" id="1593423at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021424">
        <property type="entry name" value="PorA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11271">
        <property type="entry name" value="PorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="435" mass="47200" checksum="01CD739E828F04CE" modified="2014-06-11" version="1">MRRGIGFTLICVGLFLAVLGGAIRYWAHDRLVVVPVDLYGTVDLTGKATYLDMTTLEEKTGSVVARQTVRADVDASSDRVLVVDLSQVISTADGQFIRASVERAAIDRRTGSAVNCCAESVDEKPTRHEGYLFKLPFDAPRGDVMLWDGTSASANPGEFVGTETIAGHLVYRYVSEVPGRQIRTREDTGALVGEARAYDAPVWNSSVRTMWVEPVTGTPLAVQVQTRTTLRNSRGQDEATVFAATLRSDRAKPNPETLALVAESKRRIETVRRVPVWGLGGGGLLATFGIVLLLGRRRRSVPVSPGLPPVADPERVTAVPRPDVSSRPDASSRRLDVGPRRNAGPGSGAGFWREVGPGQPVAPAPVADRPLSRYIRPYLDGDTGAHRRPDTTGSHRAPDPLDPDTDWLTLIGPESDHTVAPPEPREPRNRYPDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWQ0</accession>
    <name>A0A010YWQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="29958" checksum="0DA2422E2C955A11" modified="2014-06-11" version="1">MGHEERCVIRVAVVDDDEILLHGIEAWLCQGNPNSGSAPDGLEVQVVATAKSVLDLLSGASRPSQGPPSVPPPNYSLHRNNGISRPLSVGRASVPTMRPSPYAEEPAPRTAAPVALMDLRLRDGRRVAENVQALIKAGYAVVTCSTIDDAGFVHEAGRAGALSYVRKSREAGDMRQALAAAARGERYVSQSHAALIQRARSYGVPELSGQEREALRLYASGLTMSSVARRLNVKQGTAKSYLDRVRDKYEQAGRAARTKLELRDRAVEDGVLSTPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX41</accession>
    <name>A0A010YX41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848489.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.749"/>
    <dbReference type="HOGENOM" id="CLU_139698_0_3_11"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="105" mass="11512" checksum="AF15B1DD99DEE41D" modified="2014-06-11" version="1">MAYVVTDACIDVQDKSCIEECPVDCIYTGPRMMYINPEECVDCGRCEPACPTVSIYHEEDLPADREQFAAINETVFITLGIGSPGGARKIPPLAADHEEVASWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX83</accession>
    <name>A0A010YX83_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569714.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.796"/>
    <dbReference type="HOGENOM" id="CLU_087540_0_0_11"/>
    <dbReference type="OrthoDB" id="1828335at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457983" description="DUF1775 domain-containing protein" evidence="3">
        <location>
            <begin position="38"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="25762" checksum="1E22722702DE19BD" modified="2014-06-11" version="1">MTETTDRRPTGRFLARAAAVVLATGVAALGLAGPASAHVRVDPGEATQGGYSALTFRVPNESSTAATTKLEIALPADSPFASVSVKPVPGWKATTTSGKLAKPIEAHGTQVTEAVNRVTFTATSKATGIQPGEFQEFEISVGPLPEDKDKLFFKALQTYSDGEVSRWIEEQTGSEEPENPAPELKLVKGVAEGDGHGDADAEPSAAAATSSTSDSGGNGLAIGLGVAGLVAGVAGLIAGLMALRRSTATSASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXD3</accession>
    <name>A0A010YXD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.863"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21980" checksum="B20661482E1490F9" modified="2014-06-11" version="1">MDRWRRARATAPPPDSDDTDVLGTLLTRVGRGDDDAFAGLYDEVSPRVYGVILRVVRDPSQAEEVAQEVLVEVWRTAARFDPARGTASGWILTLAHRRAVDRVRAAQAATDREKRVAVPEAPAYDAVADEVAGRLEHQQVRRCLRGLTDVQREAITLAYYGGQTYREVAATLDLALPTVKTRMRDGLIRLRDCLGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXN4</accession>
    <name>A0A010YXN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848729.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1831831_0_0_11"/>
    <dbReference type="OrthoDB" id="2036270at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15212" checksum="DE8C94A57F07D65B" modified="2014-06-11" version="1">MSTLLADLLAAPGLYRGRGDGAESGPFLARLVVTPVVSARGVVIDYEATSDRRGLHHVEHSVLTTSEDGRQALHVCCTELPGVVTFNESKPGIFTAYDGGLTARIVITAPQPGSLTYSWWWTRDEGEPKEQFRADVRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXP2</accession>
    <name>A0A010YXP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1010"/>
    <dbReference type="HOGENOM" id="CLU_026225_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="675" mass="75647" checksum="D894E6262F18556C" modified="2014-06-11" version="1">MVIPPTLHSSNTGAKEPVWQASDAIAAAAGWDGADATMLMDLGWDDAGYGPYDTAPIGVGFVGQDLNQTIHQLSGGKVLSAPASGPAMRARRVRRHALLPDTFVPAMRPGRRYLIHFLTAGWLVTMVFFWVWWLRPEHRHGWAGLLINSVLLGYLSLYPILPILRFNKITTVNPQLPVPYLRVAFCVTKAPSEPWETARTTLEAMLRQDFPFRYDVWICDEDPGDETLDWCRRHGVRVSTRRGQLEYQRDTWPRRKKCKEGNLAYFYDHYGYREYDVVSQLDCDHVPGPTYLREMVRPFADDSIGYVAAPSVCDTNATASWSARGRLYRESSFHGPYQAGCNVGYAPSCIGSHYAVRTRALRDIGGVGPELAEDFTTTYLLSSAGWQGAFALDADAHGEGPPTFAAMLTQEFQWSRSLTTVALSMTRHLRRMPWSLRLRFLHALLYYPLLTLTTAAGLFLAPFAVLTGLQWVDVPYLEFLVRWGAVNIWLIGVVYLLRGGGVRRPNRAPIVSWEDWLYMLTRWPLNLRGVLAAAVQRVRPRPINFRVTPKGSDGFEKLPTGLMMPYFLISLVLSGTALVGELVLHTRSGGYLLLTLIAANAYTLVGLAVPWLHAREAARNARVGFFAAFGKTVPLPFTLALLVVIPFALAVANYPFEFLRTLLQLDDLIRLKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYR9</accession>
    <name>A0A010YYR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849222.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150361_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="25633" checksum="F0383BF1C789129C" modified="2014-06-11" version="1">MADSDVPGSVHDPATELFGRLRDDPSEAFAGPGESVTARLGRRRRRNRLAAVGALVLVMTLVVGYALRGTEQPDALRPVSPATTTSAPAPTDDDGQQNPLSAVDWRNATLDVPGNEDCGGAPELSFTAGLAHADVPDLGSIGYQVFDGLGESGPRYAELTDDGVKEAVLTFRCSVFYPGTDDPAAQFYFVATYESVRGLPALSKTIAELTRSEGPPRVEQSDGRLQIFTVDGTRVANWHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYU5</accession>
    <name>A0A010YYU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569875.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1441"/>
    <dbReference type="HOGENOM" id="CLU_085376_5_2_11"/>
    <dbReference type="OrthoDB" id="1069752at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="20666" checksum="162384D38BADA9D3" modified="2014-06-11" version="1">MSDDRPTPTAPAPRAAALDDDPAAVGRRIRALREERGISLSELARRAGIGKATLSGLETGVRNPTLETLYAVTGRLGVPLAAVLSPPAAGDPHTAATVVRGAAGEATLLEVIEEPDATYELYRIHIRAGATQVSPAHGAGVTEHLTVFRGDATVGPVEAPQQATAGAYVRFRADTPHFYAAGTDDFEAALLIRSPRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZG1</accession>
    <name>A0A010YZG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1656"/>
    <dbReference type="HOGENOM" id="CLU_079554_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24639" checksum="5851A88329599939" modified="2014-06-11" version="1">MNLAWAPGMRLLSDAGPAAWVEEALAPSSTRFTVAGMVPPVFAAYARVLPPTYAPENDGRHRWSEIATARGVPLTADTRFDDLVAGSNRWGRPSDGGLDARETAVLAKTLSAFTTTPDQAFFCLWDGLGLDETQALWDRPTRVRAPHRDYHLLAGPVAAAPVLPEPLDFRCANLWWPADRAWLVATEIDGYLTYVGGSEAAITALIEHPDLDAVRVLASTRLDPSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0D9</accession>
    <name>A0A010Z0D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850048.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1978"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="33308" checksum="263D0EC6946F488E" modified="2014-06-11" version="1">MTVITTRSLAKQYDGGVRALDDLSVTIDSAVVSGTGTTGGVVGLVGANGAGKSTFLKIVLGLLPPSSGTIEVLGLDPTVDGELVRARVGYMPEYDCLPPDISAAELVTHFGRISGLPKATARERASETLRHVGLYEERYRQIGGYSTGMKQRVKLAQALVHDPDLLLLDEPTNGLDPAGRDAMLDLVRRIGSEFGITVVICSHLLGEIERICDYLVALDGGKLLRADRVDAMTAGQDELVIEVDDGAEALAELLRSREIAATHDGRTVVVPLVDPRTYDQILDAVADLHLALHRLDQRRHRVAELFARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0G5</accession>
    <name>A0A010Z0G5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850072.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2003"/>
    <dbReference type="HOGENOM" id="CLU_000650_5_2_11"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="219"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="465"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="625"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="778" mass="83767" checksum="0394812347AF1F36" modified="2014-06-11" version="1">MDELDDIVQEFLVESHENLDQLDRDLVALEQHPDSRELLSSIFRTIHTIKGTSGFLAFHRLETVTHAGESLLSRLRDGAQSMNVESANALLRMVDTVRGLLTSIEENGAEGEVDVQSVIEQVTACIEDGSGKPKAAPAAAEPAAEAPVPEAPADEPAAAEAHADAEPEPAAEEPAPEEPAKPAAPVQRAGGAGAPPGPPEPGEEGSAPQRRSVAESSIRVDVDLLDALMRLVGELVLTRNQLVRGVSEMSDPALTRTTQRLNLITSELQESVMKTRMQPIDQIWSKLPRVVRDLSSQLGRQIRLAMEGKDTELDRSLLESVKDPLTHLVRNAVDHGIEPPDVRQAAGKNPEGTLTLRAYHEGGHVVVEVADDGAGIDPERVAATALDRGVITRDQLARMETSDILQLLFQPGFSTAKKVTNVSGRGVGMDVVKTNIEKIGGTVDVDSTPGRGTVWRLTIPLTLAIIQALTVECSTEQYAIPQIAVDELVFVDGSSDKNIEHVSGAPVYRLRGKLLPLVRLDESLGLPVGSNDKDVYIAVLQAEGRRFGLVVDRVLNTEEIVVKPLATLLKDIGVYQGSTILGDGKVALILDVQSLARRSLLAAQAVEKSGLGADAQQSQNRQGSGNRLLITGVGDRRVAVPLDMVTRLEEFPIDKIERVGSREVVQYRGRILPLVRLAHLLGAYPAEDGDSVPVVVYSERGRSVALAVEKIVDIVEDSTDTHSDLDDSGLTGSAVIQQRVTEMLDVRQAILAADVNFFDAMDEYEDQYAGGLEEMSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0H9</accession>
    <name>A0A010Z0H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein containing EAL and modified HD-GYP domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569987.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2018"/>
    <dbReference type="HOGENOM" id="CLU_044951_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HDOD" evidence="2">
        <location>
            <begin position="215"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="44726" checksum="894888188EA52217" modified="2014-06-11" version="1">MHPVPAPPQPVADSTETLYVARQPIVNRDGQLIAYELLFRDAPGATASTERAAAATSRVLVNAFAEFGLERLVGDRLGFVNLTAEFLAGDLPLPFAPDLAVLEVLETVEVDDRVVAGVADLARQGYAIALDDFVWGTSIDRLLDYATYIKFEVAGVDPTLLGERVAIARRRKRSIKLLAERLETDADYQLARDLGFELFQGYLLGRPETLTAEAISPSKARQLELLGLLTSPDVDLPKLSSVIAADPGLALRILRATNSASVGQRRRIASIQDAVVILGLERLRQWLAVMIVSDLSGAGEADLSIPMVRGRWIQNIATQAHLPADVGFTIGLLSGVAELLGVDARDLADRLPLTDEVQAALVEEQGEFGVVLNAIRAYESGARGMARVQNKLSLAVLAKSYLEAAAWQVSTSAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0I4</accession>
    <name>A0A010Z0I4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FliO/MopB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569988.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131987_0_0_11"/>
    <dbReference type="OrthoDB" id="2084487at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03500">
        <property type="entry name" value="FliO_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="18143" checksum="3B1B98257ABEB7C1" modified="2014-06-11" version="1">MIEATLRAVFSLAVVLLLMWGLARLVRRGPGGRGLSSLAVLSRQQLSRGASVAVVKVDDRALVLGVTDAQVTYLTEAPLAAFERSAPFSAVLADHVGDVLSSGPEDRAPVSPAPADPDRPRPVRARPARGARHAARESAPGPLAGSVLSPATWSQVVGFVRTLPPKFGASRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0N0</accession>
    <name>A0A010Z0N0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850166.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617803_0_0_11"/>
    <dbReference type="OrthoDB" id="1452079at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="316"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="47442" checksum="284C6F99533D3212" modified="2014-06-11" version="1">MSDRARVRRLIDALDRDTVADAVLQALRASRGLDGHSSAEPRAGNPRWTAVPPLVRDHVRMFTRMLHSGEQPTRAELRALVRQAAAASQSPVEELLRSYRVAAEAASRAVRSAAGAEDLAAVVTVTEEMMAYVNLTTAAIVQASLDDRDLRRSERERRFRRLFDALDGAAALTADLVELADDIGLSTNGPYLPFTAARRDGSAADHARLAAELTAAGGVLAFSEGTRIDGICRSQSALELLAGLDEVAVAVGPPASRGRLGAACHDLHVVIDVAMRRGRTGQIGLADFAPEVLVELCPEVSDALAARVYDPLPDDLRATLHALVAYGFDRTATAATLHIHRNTLLYRLGRIEERLGLDLSRAADQVAIYLATLRHDRARETTPPPPVTPPPGTHRAPPAGSDPPRLRPPSSSGPRAPHPHEVALAAGDRTGTPTRLVVRAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z120</accession>
    <name>A0A010Z120_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850323.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054755_0_0_11"/>
    <dbReference type="OrthoDB" id="949624at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="412" mass="44078" checksum="58628A6974A45677" modified="2014-06-11" version="1">MSAPSVVSSASRVRLHSLHLREDDGSWIVGRVETGDFIAIPPVGRRALTLLPDHTVAEVQTRLRDETGDEVDVVDFVSSLVEIGFVAEVDGHDVESGPVPRSMLARLRPEHVRWLLHPATALACAFVVLVALAALAFDPGLVPEPHDLLWSTLGFAVLLGNLAIVWTLILLHELAHLFVARAAGAPGRMSLGTRLQFLAAQTDVSGVWAAPRRARFSVYLAGIVTNLVVAAVAVLVRAAGVGGRPGEVLAAVALLSLSLIPAQFLVFMRTDLYFVLQDVAGCANLYADGSAYARFLVGRLVRRRTAEDDPSRRLSGRERTAVRSYTVVLVVGTIACLAIEVLVTLPVAIALFTAAVDTALTGGTATQLLDAGAVAFTTVLFVVLWTRAWWRQHGSQVRRGMSRVRGSGTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1Z8</accession>
    <name>A0A010Z1Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850797.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2528"/>
    <dbReference type="HOGENOM" id="CLU_009942_6_1_11"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="51"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="544" mass="57860" checksum="86E172D133A54E69" modified="2014-06-11" version="1">MSEAPADLLFTGGPVLTTDPARSRSRSLAVRAGRIVALGPDAHALRGPKTEIVDLNGRLLLPGFQDAHVHAVFGGLELGLCDLTGTTDRDEYARRIRAYADANPGAEWIVGGGWAMESFPGGVPTAEILDRIVADRPVYLTNKDHHGAWVNTPALERAGITRDTPDPSDGVINRDVGGNPVGALQEGAMALVGALLPDVTAADRLAGLLRAQALLHSFGVTAWQDAMVGATNGYPDIADAYLTAAREGLLTASVVGALWWDRDGDASQIPGLVEKRERYTVGRLRCGSIKIMQDGVAENFTAGMTAPYRDACGGTTTNAGLSFVDPIALRGYVTELDALGFQVHFHALGDRAVREALDAVEAARTANGYRDTRPHLAHLQVVHPDDVPRFRRLGASANLQALWAAHEPQMDDLTIPFLGGDLATHQYPFGDLLRAGATLVAGSDWPVTTADPLQAVHVAVNRRLPGSERPPFLPEQRLDLGTALAAYTAGSAYVNHLDDTGTLRVGNRADLVVLDRDPFDHPADEIGATSVALTYVDGTLVYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z208</accession>
    <name>A0A010Z208_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570088.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2541"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_0_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="36362" checksum="E2C5F446F7EDF329" modified="2014-06-11" version="1">MTRLSPIVRHRLFWPAAALVLLLVSNLFFSTDFFAVRIKDGHLYGSLIDILRGSTPLVLVALGMTLVIATAGIDLSVGSVIAIVGAVACLRVSELDDQNSVTGVLAAVAVAVVLSLVLGLWNGVLVAAVGIQPIIATLILLVGGRGIAQLITDGQIINVRSSPYRTIGAGYALTIPVAVIIAAAVVAVAVLLTRRTALGLLIESVGSSPTASRLAGIQARRLTLIVYVFSGFCAGVAGLIYSSNISSADGNNAGSLIELDAILAVVIGGTALTGGRFSIAGSVLGAVLIQTLNITIYTAGVPGRFTLLFKAVVVVVLCLAQSPTFRAKVFGRWRRSKPPTAGPTPGAPAPAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z306</accession>
    <name>A0A010Z306_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851224.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713131_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="38245" checksum="967D400A48C0971C" modified="2014-06-11" version="1">MNELDTALRTLYAGRADRAPSGTDLLSAVHGRARRDRRRRVLAGIAAVVAVVLAGGVGVALTHRPEENRTLQVTEGKAAAPPPAPISVTRWPEGYAKPAVQYLGQGVWDIESRAGSAALSVQVMSYRPAVRPGPGQRQSIPVDGVPGTLYWLPPTLAAPDPASPDPTGPFAELTYQRKPGQWIRIVGVNVGTTLARAMLRLFSVAGHLTDRKSPVVDTIRLALPDGTAWGRVDAAGSHSRVMLVDERTPVAAVALNDLPDSRIVTQQRRAIVEVVDKDGEIVRNLPQITGQGGTLTSSEVGPEGRVFDLGTIRWFVHLVAGSERAAVVIRVDTTDPLADVGTLRRLAESVRLGVDAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3B6</accession>
    <name>A0A010Z3B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851376.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034174_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="12551" checksum="147F86EF64DA07EA" modified="2014-06-11" version="1">MQASRPAIAGTNPIRSVAHAVTEPATIITTIRVSSVGSAPLRIRFGVAAVGGIGRNCASRPLAVPDPSATIADRTSTATSAVLSRAWPEPTVSRPTTPSTIGSRQIRVVSTGTHRICRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3P1</accession>
    <name>A0A010Z3P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851521.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3105"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="799" mass="87274" checksum="156B06C5FC338085" modified="2014-06-11" version="1">MPGRDRPHDDSTSSDLSGSAGDVVQARDVHGGVHFHTPTAPPAGTPRQLPADVRGFVNRHHELGIIDALWASDPDELPRTGVYVLAGTAGVGKTALAIHLAHRVAPRFPDGQLCLNMRGYDPGAPLTAADALDRFLRALDVTPTAIPTDVEDRAALYRSRLAERRVLILLDNVATVRQVRPLLPGTAHCLVIVTSRSRLSAPAVRDGAQRITLDVLPETDAVTLLDNLTNAYRPHEDREQITELARLCARLPLALRVAAERAASRPLMPIDLIRDLRDEYALWDALSAEDDDESDAVRTVFAWSYRALPEPAAQLFRLLGLHPGPQFSAPAAAALIGDTLGTARHLLDVLAGAHLIDQIAPDRFQFHDLLRAFAIDQGRDDAGPGRIAALRRVITWYAHTANAAESRIGILDLAIPLPAQAPRTPPPDFDAERSAALWMDTENDNLLASIRAAAREPELQELAWRLAALTRRYYMRHNLFDAWFASAHIGLDAARAIHDQHGLAEMHDSLGMAYVATQQLDNAIRHHTAALDIRRDLGDQLSEAVSLNALGLTKLRARHLTNAANHFAQSAALFDQLGDASWQAFAQLNLAGTLVELGELTQAVELLEQARAQFRAENSAEGEGNALRLLSRISLRENTFSDALRYARAAVDIAVEAENRMWEGFWLLDLGAAQLATGNTADALISYQRSASIQRRLGDRVREALALNGTGHIYQRLDRVDEAINFHRGAVLILRTVTAAWNLATALNDLAAALVKTGRRSDAESHWQEALALVDDLADPATDQLRESISRSLAMLAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3T8</accession>
    <name>A0A010Z3T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3149"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="817"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="888" mass="95233" checksum="A7F7CA74AC78FD0D" modified="2014-06-11" version="1">MLSEAAEGRGAALLIRGAAGVGKSELLRSVGATAAAEQNLTVLSAAGAEPERWFPFATLQLLLQPMADRINTVPGTHRMVLRGLFGGAEAMPDVYRVGLAVLELLAEAAERQPVLLLIDDMHWVDSSSRDVLGFVARRVSAHAVVVLAASRSTEPAFPEMHLEPLAPTAAADLLDASGRDLAAPLRTLILERAAGNPLALVELPKAAPDAPLGPDDLPLTRRLETAFADRTTTMSPTGRTFLRVLAAAPTAPTDRLLEATGQLTGEPVGIDAIQEALDADLVSVDRNTIEFRHPLMRSAIYEQASAAERHAIHRTLAAVLSDDIESRLVHEAAATIGCDDELADRLVDFAEQSRSLGRLAASVQALRRAAELMRDAQRRTTALVLAAELSSQLSDRHRTQALLARANLSVVGPVERARLLIMSDSAAFEPDEPHRRISDMTIAAGGAFDAGAREVAEDLLWRAAARCFFQDADRSTRAKITAELARWRPDPASPHAVIIRAYAEPYLHGSEVIRGLNTVSPGSADGRLTHFLGSGAMVIGEFTGSTRYLARAAAALRSQGRLGLLARTLAGAWPRFYLGQLDRARADAEEGLQLARETGETIASLGLGASAGLIAAMRGDHETATQRAQEVRASSMFDGMPFAAAIVRQTDGLLALQDGRATEAYAILASVFDPTDPHHHSVSRWLLVPDLADAAVLAGTVEHARELLGELPRLTGLLPSEMMRTAHAYATAVLASDESAEQAYSDGIAALPSGVALIRARLQLHHGRWLRRQRRYTAAREPLRAARDAFDRLGARPWAETASSQLRASGEVGNRRRPSPGEQLSPQELQIAVLASQGLTNRQIGERLFISHRTVGAHLYRIFPRLGLTDRRQLAAALAAGGLELTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3W0</accession>
    <name>A0A010Z3W0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851631.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="26320" checksum="584B39698E19A417" modified="2014-06-11" version="1">MSTTLTGTTALVTGASGGIGAATALSLAAQGANVALVARRKDRLDELAERIRTAGGTALVIEADLTDQTRAAAAVEQTVQAFGGLNILINNAGVMLLGPAESAPLDEWDRMLAINIQGLLYTTHAALPHLLDAAASERASADIVNVGSLAGRVPIAGSAVYSLTKTGLNAFTEALRQEVTGRHVRVSLIEPGPVATELFTHIRPEILAAGQQAFANATLLHAEDIADTITYVVTRPARVVMSEILVRPDGSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z411</accession>
    <name>A0A010Z411_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851719.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3227"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="376"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="409"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="625" mass="66610" checksum="AD2D0242D5916DF8" modified="2014-06-11" version="1">MSPARRLLRMLRPFRPAVLVIITFGLLSAVLNLVGPLLMGRATDLVVAGYLSRGLPSGTTSAEAIAALRAQNRDSLAAVLSTVDFAPGAGIDLAAVGRLLGLTLVLMVAASVLTAVRDRLTARIVQRVAAGLRRDVARKLTRLPLSYFDGHPRGELLSRVTNDVDNFQQVVQQGVGQLIGAAFSIVAVIAVMFALSPLLAVLVLAGTPLSIAVMTLISKRSQPRFDAQWAATGALNAHIEDIYSGHALVVGYDRRDLAAEAFDRHNDAMRLAGARARFLSGTLEPVMTFAGNLNYVLVAVVGALRVASGSLSIGSVQAFIQFAWQFNQPVGQLAAIAAQLQSGLASAARVFELLDTPEQSPDPWPPVVPGPTVGRVEFDRIAFRYSPDTPLIESLSLVARPGQTVAIVGPTGAGKTTLGNLLMRFYEPTAGRVLLDGTDIRDLTRDDLRSRIGLVSQDVWLTRGTVAENIAFGRPDASRADVVTAAEATCVDQFVRGLPDGYDTRLDDEHTTLSAGEKQLVTVARAYLARPAILILDEATSSVDTRTEVLIQRALRSLRAGRTTFVVAHRLSTIRDADVIVVMDAGRIVEIGAHNELVAAGGRYARLYATGTAAPLEEDGGADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z542</accession>
    <name>A0A010Z542_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease-like transporter, MFS superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852270.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3619"/>
    <dbReference type="HOGENOM" id="CLU_003182_13_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="439"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="568" mass="58286" checksum="C402C601815C12AC" modified="2014-06-11" version="1">MNPALVRCARGVRAVLPVGADFRLMTRNPGRDLLAGVTVAVVALPLALGFGVSSGLGAEAGMVTAVIAGSLAALLGGSNLQVSGPTGAMTVVLVPIVARFGPSGVLLVGLMAGALLIGLALLKTGRYMAYVPAPVVEGFTLGIACVIGLQQVPNALGVEKPDGEKALTIAWRSVLTFADAPDWTALALSAGVAAAIVAGARWWPTIPFSIVAVAASTIVVDVFSLRDATRIGALPTGLPAPSLSFLDASMVDDLFASAVAVAALAALESLLSATVADGMTVGQKHDPDRELFGQGVANLVVPLFGGVPATAAIARTAVNVRTGASSRLAALTHAAVLGVIVFAAAPLVSRIPLAALAGVLLATAIRMVEVGSLRAMARATRSDALVLVLTATATLVLDLVSAVIVGLVVAGALALRAVARQARIDQVDFRPDLLGEHSDEEHALLAEHIVAYRIDGPVFFAVAHRFLLELSEVSDVRVVVLRLSRVSTMDATGALVLKDAVEKLNRRGITVLASGIRPAQRQVLDSVGALDLLGPDGHDHRTTPEAIAAARRLLEQDGLVSADDRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5D0</accession>
    <name>A0A010Z5D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type bacteriocin/lantibiotic exporter with N-terminal double-glycine peptidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852419.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3710"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="350"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="614" mass="66308" checksum="B3A700EF0C499D6F" modified="2014-06-11" version="1">MTPRSARGIRRAATIFRRALGIYVGAAPWAAAVSVGVMVVAGLAPVAVAWSTRAIVDGLSAQDSTRIWAGVLGFGALAVVTPVVSHLSGYVRSETERRVTVRTQVELFSAVSANPGLTELEDSTYHDRLRLAREASQFAPAQLSMVFLGVGQDVITIVGFAVPLLRWSWVVGLLILLATVPTFVAQARLARLRGAMMERVAPIFRRQAFYAALLLDMRAAKEIRLFGLSGFFRGRMIRELRSAQRQEREQDRLALGVDSGLAALTGLVSLAALGVFVREVAGGRATIGDLVVVIAALGALQMSVSSLVQQIANLGETLIMFGHYVDVTAGARRSAAASSLPPAPRLRDALEFDDVWFRYAADHDWVLRGLTLRIPRGTSLALVGSNGAGKSTVVKLLCGFYGPTRGVVRWDGVDISTYDPASVRARIGAAFQDFMTYDLSAHENIALGDLDGLDDTDRVRAAADTAGLDDTLRKLPRGYDTLLTRAFSDDDAGFRSTGVVLSGGQWQRIALARAALRVEADVLVLDEPSAGLDVEAEHEVHRRLTALREKRTSLLISHRLNTVRDATAIAVLQEGRITELGTHRELMACGGHYADLFRLQASGYDDTRADRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5R0</accession>
    <name>A0A010Z5R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570625.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3846"/>
    <dbReference type="HOGENOM" id="CLU_355598_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="561"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="758" mass="79156" checksum="B4BBFECF761B70BA" modified="2014-06-11" version="1">METERRSQPRPPNRLSTVPLVLCVALYCFLRVTDYVPVGPFDLHLDRVEFATAVTAVVAVGVVYLLLAFRRPPRPVATGLLLTLAGLTYGPYALVHAGWSPPVAVIVAAVLLTFTGRPSWLLAALVVASDLAVRIALEPGLVDAGGAIVPGRVSYAAIVAVANGLLLFGVARLSQLLRDADRASAGRAALAVTRERLRGARHLEEAVGSRLAAVIAGARADDGDPAVAARAAAATAREALAQVREVADGYRDRSLASEVDAARVVLTAAGVPVVAGPVPADLPEPVDTLLGAVLRRTVVGALSGAPPSSCRIELDGSARLRVACTGGEPGRPALDDLTGPVERLGGRLRVDGPGDVEVELPVTPHGPFRTPVPRPVAGEPWLAWAIMAVLELDLLVTTIVRAGGAWEPIYHAQLSGLRLAAVLALVVPLSLLQLHHVRPRGGDAPPWWRWTLGLQIALVAAITAVGGAAVPAPQYAGPVAGVVLFHLRRPVSWLIAAVLIVGTEVAEIRNSGFDFPADLPYLVPWTLLAMVSVAALCRLPVAAEQVVASQRELARLAALRERLRIARDTHDLLGFQLSAIALKADLVGRAAGAEARDELAEVGRLAEEALNSVRSVTAPPAGLSFADEVRSARSMLTAAGARVDVALDAAPGPSIEGPLAIVLREAVTNVVRHSRATTCTIETRPVPGGIRLRVTNDGVTHNGVPRGSPPAAPGHGLANLRARARETSGELTVARSGERFTLDALLRESGRSALSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6A6</accession>
    <name>A0A010Z6A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3288271_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459009" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="40" mass="4023" checksum="E6C03FADE7FBBEB9" modified="2014-06-11" version="1">MTRTLQRIALVLAAAAVAAAAAAPASAADDATIQKPVRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK78</accession>
    <name>A0A010ZK78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753809_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="367" mass="38298" checksum="42D3AB7D371C362C" modified="2014-06-11" version="1">MLDRVVAGLLALGTAGGLFAAYHFVAEAVQHHEALRTGRSSVENLDPGTALPTVYVLGGFVLGFAVLFGVVAVLIVRASPLGFPALRGGVTVLLPAMLLAYLATYTRYQQWREAMPPGTQDGRYRVVIVGEVIGGAIGVFGVVLAVLVPLGAVLVRWFRPGEVSGPVPAPGSSAGALNVARILALAGTAVALLVPVAWARPLGRENELPTEWSVIATLSGFLAVLALVAAGLLLLARPGRLMFRWLALGATAVVAAIEWVGIVWQAFYADVAFGTERVEGVAVAWTAAIVSGVVSSGLLTAAVVTLVIPRPPEAVEPADGVTVTRRGDGPAPERIGEATPEPAWQAFPEAPERKAAATPKRKKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL50</accession>
    <name>A0A010ZL50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569611.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811196_0_0_11"/>
    <dbReference type="OrthoDB" id="1442101at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="40460" checksum="24EB885BCF15758A" modified="2014-06-11" version="1">MRKQHEDDPGVDDRDGGTLTLPGQYEDAPDYDFRVANQDTPTEMLGGNTPPYGVPVVADVPEPPAPPPPYEPPTFTAPAAVPEPPVRDRLWPHLIWEIVLAAAVVTEVLLVLAQDDQVFRGDAGPALMLWVATAILLGSAAALSLRGGMPNVAIGAIAIAAGADYAWLVGAEGHPFGEALAMALAGGALAGLVIALISTTFGVPSWAASLGVAGVLSGVVPALVGYAARPVGGETPNVHVSAEWWLIGAAVISVLGGLLLAQPAFRRFVGRSRPTGDPAKRAGFVASIAAAGALAGSGALAAAAGLLDAANRGTSAGGYTGMAELAMVGFSVALLGGVSAHGRRGGIFGVVLAATLLGLVRLHLDLVGADKWLGAVISGAAIILGLVVTRVMERLGRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL80</accession>
    <name>A0A010ZL80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_0449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569618.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.433"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_6_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="28"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="340"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="684"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1042"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1250" mass="132452" checksum="8A0E2953989670E8" modified="2014-06-11" version="1">MSTAPSPGWIRRLFAISWSRHPVLVVSVIAASLGATLVEGVVPLLTREAIDDAIAGRVDRVTLITVILAGLGVVRFAAIFLRRYTAGRLSLDVQHDLRNAVFTTLQRFDGPRQDALRTGQVVSRAISDLQLVQGILAFVPFSLGMVLLFVIAVVAMFSLSVPLTLVSLAVTPAVAWAAGRSRRTLFPATWSAQQRAGEVAERVEEAVTGVRVVKGFAQEAREVAELETSARRLFADRMRAARINAVLTPTLAALPQLGQVAVLALGGWLALTDRITIGTFVAFAAYLATLAGATRVLSGLLTQGQLARAGVERVYDVIESEPGVVDPAEPESLPEGPLSIGLDRVVFGYSADDTAIDDLTLEVRPGETLALVGPPGSGKSTVAQLIGRYYDTRSGAVTLGGVDVRRLRLAELRGALGVVFEEAFLFSDTVRANIAYGRPDATDAEVEAVARAVEAHGFISALPGGYGTLVGERGLTLSGGQRQRIALARALLTDPRVLLLDDATSAVDNVTEAAIHATLREVTADRTTILIAHRRSTLALADRVAVLDGGRLVDVGTQAELTERSPLFRALLAGPEDGVAADPVGEQGTTPDRGAEGITPELWPAVEDVTDPLVTAREPASGGRAAIGLHGDQGGMPATPELLAQVRALPPADEVPELPGVDPRAADPRFRLGRLLRPVRWLLWATVGLIAVDALATVAFPLLAQHAIDAGVVGNSRVQLAVAGALGVVVVVVDWLAVRTQTVTASKAGEQVLYLLRIRSFAHLQRLGLDYYERELAGRIMTRMTTDVDALSTFLQTGLATAVVSVLTILGVTAALLITDAGLALVALAVLPIVMISTLFFRRLSAKAYEQARERVSIVNADFQENVAGLRVSQAYVRETRSAADFARRSDAYRQSRMRAQTLIATFFPFIGLLSDLAQAAVLAVGAHRIADGAVTPGILTAFLLYLGLFFQPIQQLSQVFDGYQQARIGLGRIGDLLRTPTSVSDTDAPAPVPAHLSGRIELRDARFRYTGADGEALRGVSMTIEPGETVALVGETGAGKSTVLKLLARFYDVTDGAVLVDDVDVRRFRLADYRSRLGVVPQEAHLFTGDVASNIGYGRPSRSPASIEQAARAVGAIGMVGAIRDGFRHSVSERGGGLSAGQRQLVSLARAELVDPDILLLDEATAALDPASEAVVLAAGDALSRRRTTVVIAHRLATAARADRIVVLVDGQIAEQGTHAELIAVDGVYAKLWARDGAAATAEELDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLV3</accession>
    <name>A0A010ZLV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase sigma factor containing a TPR repeat domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848403.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.666"/>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="45361" checksum="D5830A96B665FB49" modified="2014-06-11" version="1">MTDDHVRRTLDAVWRIEGARVVAGIARLVRDVGLAEELAQDTLVIALEQWPRDGVPDAPGPWLRATAKHRAIDVLRRRQRYAEKLAVLGADVVAERDRTDDLVDDLDDHIGDDLLRLMFTAAHPVLSTEGKVALTLRLLGGLSTDEIARAFLIPEATAAQRIVRAKRTLSAAGVEFSMPTPAETAERLGAVLGVLYLVFNEGYAARSGSDWTRPALCREAMRLGRVLAGLLPDEPEVHGLVALMELQASRLPARIDAAGRPVLLDDQDRRRWDRLLIRRGLAALERAESLGGGAYTLQAAIAACHARALRATDTDWPRIGALYEVLAYVRPSPVVRLNHAVAVGKAGDPSRGLAITDALAAELRRYPHLPAVRGELLAQLGRAAEAAAAFRRAAELTRNDVERALFEERAATLEPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM06</accession>
    <name>A0A010ZM06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.724"/>
    <dbReference type="HOGENOM" id="CLU_040769_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="32052" checksum="0845670E50DFBF8C" modified="2014-06-11" version="1">MIGTDEITTIVASSLRLTAPLAFAACGEYLAERAGTQNISVEGMMLGGAFGSVAVASATGSATTGLLAGAIVGLVVGFVHGNLSHRIQINTFVVGLVLNAFVLGLTSFLIAVAEFDSNQVGQLSIPGLRDIPIIGPLFEQRWPMYLLLLIIPLTWWLVERSRWGLNLRAIADNPQAADVTGLKVNKLRRQALLYAGLLSGLGGAYLATAEVGSFNMNMTAGRGFIVIAAVIFGAWRLKGTMIGCLVFGFADALRLALPALGFELNSQLLVAAPYLMALLAMMLFASKTREPRALGKPFVRGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMD6</accession>
    <name>A0A010ZMD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="372"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="53679" checksum="32215216F5039BC6" modified="2014-06-11" version="1">MQRSAFFRAACTDRGLLALVGGLLLASSWLIFGNTPEPHRTTLFWAVQAPGDLMFFLSALAVTRNARDDRRAYRFWRLLTFAGGVFVTADVLRTAEGVVGLETTESGPVQLACLAIGQTAIFAALIGYPMLIGSGAARQRFLLDASIVLAGVGAMVWFLLADPRAANTTGGGVIGGLVIGVGVLAVGFFAVKLVLSGHSPVALPAAATMIASAIVLVGQIVVLPIYAGPLDPGVALAVQLLPTALIAAGPRLELLRFRVDPEHFRLRTRRRPYSVLPYGVVGGVQLLLFGAFVIDDELTLRCWGMLVAMCLVTGLVVVRQLLSFGENSRLIGQLDHANLQLRHQADHDVLTQLANRRLFTERLDATADLGEDAVALLAIDLDGFKPINDRYGHHVGDAVLIAVAERIRRCVRPTDTAARLGGDEFAVLMPGATRESAAQLVARIERVLSEPIGIGELRLGIGASIGVTVGSAEDPETLLRAADAAMYAVKHRRQPENLMQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMM8</accession>
    <name>A0A010ZMM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569752.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354781_0_0_11"/>
    <dbReference type="OrthoDB" id="1432855at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="185"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="4">
        <location>
            <begin position="395"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="791" mass="83232" checksum="D864CA26A8A35518" modified="2014-06-11" version="1">MAHFPITPPLRALIVTPSGVLGGAESWLLSMLDHTERLHPWVVMLGDGPLREELNARGVPVIRQPTGRTGAAVAGAAARLVRTLRELDPDVVVGNGVKAQCVVAPAARLVGVPSVWVKHDHSFDRRLAGRLAKASDRVVATADDVAVAARRPDTLTITPPRSAPPVGRDEAVRILRGLNVPAGERLLLAMPVRFVPYKGVDTAIRALAEPQARDWDLLAVGPDDPTRPHERDRLASLAADWGVADRVHLRQSIPAVGRLLTGADAVAVLTRPDGPRTPGREGFGLTALEAQLAGVPVIAVDDGGPVARRVGARPFGAVSRSAGLLVPPADPPALAGALGALSDVEVRAALGAEGRRRAADHPDATTQAARFAAVLAEVAHRPGAGLNRADAPPVTVVSPVLDEAAAIDGLIGTLAAQLGPNDEYVLVDGGSTDGTAERIAAWHTEDPRIRLVRHGGGSIGYSRNRGVSAASHEFIACTDAGCTPSASWLDGFRAAAAETAAAARRLPLGGGEHPSERPVELYVGVYSAAVRPDRWFEPAMAAMNWPDPVELRRRTAFRAIYGRLFGRAFSAARVDGRSVGFTREVWHAAGGFPENLRTAEDEAFGRAVRELGARTTLTLDAAVTWYQRHDVGAAFVQFRGYGRGGGTGRSGWLLRRDAIRFGGYLGAAAALTWGGRTGRLLALAGAAGYFSLPVARVLRRGQSPLVIPLVPLAALLKDGAKLVGTAEALLGTATGRYDAEPPPAEDRTAPEHWAYGWDGDAWTVIPRPLARGFEGPPLEPAGAGQVIEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMV7</accession>
    <name>A0A010ZMV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674986_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="157" mass="16444" checksum="E53EAFA01A280722" modified="2014-06-11" version="1">MSTDPEHIGDVVARAVGRLADDDPGHPQLCGAWRAAASTLVGVLAAHETTCETCRPVPAAPPADEQVAASRDAAVALVSLALDPEHGDVDEQLHGELMTDLFAAGAPAAVASLVDLVVRSVDALLLAQGAVDEAGRSQTWEQILRNTAHLYRDEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN76</accession>
    <name>A0A010ZN76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Co2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1184"/>
    <dbReference type="HOGENOM" id="CLU_052508_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="24231" checksum="F588B91EF457399A" modified="2014-06-11" version="1">MEPAGTPVAMHVSDGIVNLPVSALFGAVAVAWIALCLVRARRDLDDRLAPMAGLVAAFIFAVQMLNFPVLPGVSGHLLGGALAVILVGPWVGALCVATVLLVQALLFADGGLSALGLNITNMAIITTLVAYGVVALALRVLPKSRLGIVVASFLAATVSVVVASQGFVFEYALGGEVDKALGPISATMAGVHLLIGVGEGLITATTVATVAAVRPDLVYVLRRYREKPLLITTGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP87</accession>
    <name>A0A010ZP87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569898.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1550"/>
    <dbReference type="HOGENOM" id="CLU_1000682_0_0_11"/>
    <dbReference type="OrthoDB" id="1831131at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29581" checksum="38944DD3A3FBE6E6" modified="2014-06-11" version="1">MTDHVTLAPGHHLFRGADDVWRLYAPGDQITRIGGPDEALAHAQNRLHNTAEAGGGELVDELERGLARRGALAQPVRADSQAAQPWTVVVAGDNPIGRAVRTLLEPYADLRPPCAGALTEDDVRAADTIVTCGGWLTDQAWSALDDWCRRHGTAWHLSYVEGTRHYLGPMYVPGRTASYRDTRGRRLAASGVPDELRGFWAYLESDAALPPVPWPDPAGAAVVAGLLVGDLLRYRRTGTPAAAGHQLGFDPAHATVTRHPVLPLPETASVPAGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPE4</accession>
    <name>A0A010ZPE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849486.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1604"/>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458243" evidence="8">
        <location>
            <begin position="36"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="194"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="750" mass="77635" checksum="0D28866F98ECB737" modified="2014-06-11" version="1">MATLLYRLGRGSFRRRNLVVALWLVVLVALGGAAVAFKGATTNDFALPGTESQRALDALAREFPAASGATGTIVVAAPEGKKLTDPSFAAAVTGLVKEAASLPGVVAAVDPYSARALTPDARYALIQVQFENRADEITEDERTAYEKSGRAALDSGLQVEHGGEVMSSPPEVGGTEAIGVVVALLVLLVTFGSLVAAGMTMLNALIGVGAGMAGLFALTSVIELNSTAPILALMLGLAVGIDYSLFITSRHRQHLADGLDPEEAAGRSVGTAGSAVVFAGITVVIALAGLSVVNIPFLTAMGLAAAGTVAVAVLVAVTLLPALLGFAKLRVLSRKARAELAAETGAEPRHASDEVAEKDSEGPGKHEGTTREAFGFRWARLVIKLRVPVIIVGILGLGLLAIPAKDMRLGLPDPSQAAEGTPARAAADLISEGFGPGFNGRLALVVAADTPEQTGAAVQKVNQALAGTPNLVAVAPPNFSPDKRTALLGIIPKDGPTAAGTETLVHDVRDRTAGIEGADVSLTGQTAIGIDVSEKLSDALPIYLALVVGLSVLLLMLVFRSILVPLKAAAGFLLTVGTTFGITVWIFQEGHLAGLVGVSTPGPLVSFLPILLIGILFGLAMDYEVFLVSRMREDFVHGEGAQEAVVSGMGHGARVVTAAALIMTSVFAGFVLIDDPTIKSVGFALALGVAVDAFIVRMTIVPAVISLFGRAAWWLPRWLDRALPNVDIEGEKLREHLAETPERELESVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPF1</accession>
    <name>A0A010ZPF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G:T/U mismatch-specific DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847550.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.121"/>
    <dbReference type="HOGENOM" id="CLU_042829_3_0_11"/>
    <dbReference type="OrthoDB" id="2034230at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="2">
        <location>
            <begin position="60"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="24037" checksum="4DED8872FDA66AB2" modified="2014-06-11" version="1">MSVARPGGRNDDRRPTPRSVAGTRPEGGSRPEGPGTASGRPRRPTKADLQAAYGQPIADTVGPGLRVLFCGINPSLWSGWSGHHFARPGNRFWPALHRSGFTPRQLDPSESDALLALDLGVTNLVNRATARADELSPEELLAGGERLVATVDKWRPRWLAVVGVTAYRAAFGRKDARIGPQADDPLFAPTRVWVLPNPSGLNAHYDLAGLAAEFEQLKIAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQD9</accession>
    <name>A0A010ZQD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.446"/>
    <dbReference type="HOGENOM" id="CLU_017959_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="491" mass="50849" checksum="81BCF78F408BA15F" modified="2014-06-11" version="1">MAFRWSVVHGGKAPPPGEVVRPDERLSWPRTIGLGAQHVVAMFGATFVFPLIMGLNPQLAIMMSGIATIIFLLIVSGKVPSYLGTSASFVGGVAAIRAQGGDSAEVTGAILVAGVVLALVGVLIHFVGSRAIYSVLPPVVTGAVVMLIGFNLAPVVAGTYWPQDQWIALITMLFVIVVAVGVRGFLGRIAIFLALLFGYALSWVFDRIFGQITSYDAAAAKETTHWRVNWDGVQSADWIGFPPHTSGDVVGWHTPTFSITAILLVLPAVIALIAENAGHVKAVAEMTGDDLDPVMGRAIAGDGVGTVLASAVGGSPTTTYAENIGVMAATRVYSTAAYYVAAIVAILFGFSPKFGAVVSATPGGVLGGITVVLYGMIGLLGAKIWKENRVDFANPINLVPAAAGIIIGIGGVSLVFTDDFSLSGIALGTIVTVAGFHLAKAIAPPHLKELWLAEQRPSRTPDDEGATETAAGKDAGGAVLVVDEPGAYKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQG5</accession>
    <name>A0A010ZQG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848108.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259681_0_0_11"/>
    <dbReference type="OrthoDB" id="2084633at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="22630" checksum="46948CD9C7C34526" modified="2014-06-11" version="1">MRRAGLGLLILLLVAACTRPADGRFVEPRSAALPLGDRAAASLHVDTGVQRIAVKVADLGDDLLRVDGARPQVTEDGDDVDVRLRGGSLQVTLTNRVTWSVTLSGGASGADVDLRGARLTRLDVTAGLDTAEVWLPSPSGAVTASLASASRATVYVPPSVVTRVSTRSGAGTVDIDGVVTTGAAAGRVWTPDDWAGQPDRYDVVVQGGVGQLTVARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQW1</accession>
    <name>A0A010ZQW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850216.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2125"/>
    <dbReference type="HOGENOM" id="CLU_062618_6_4_11"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26518" checksum="FC6756F9161D47A3" modified="2014-06-11" version="1">MAEVPAAANVLAILRYFARQAGPVGAAAIARDLRLPRSTTYHLLATLADAGFVVHLPEERRYALGVSAYELGTGYTRQAPLQRLARVPLATLVDRLGQSAHLAVLHGREVIYVIEERAPGRPPLVTDVGVRLPAQLTASGRAMLAVLPKPAVRALFPDAGAFVRRHELGPTNYAELRRLLTAVTKAGYATEDGEVTPGFASVAAPVTDHSGHPVAAVAVTFPVAEGDPDALADAVRRTAAEIARRVGGTPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRD7</accession>
    <name>A0A010ZRD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid-responsive transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051572011.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067515_1_0_11"/>
    <dbReference type="OrthoDB" id="1210594at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="171"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="28612" checksum="4950857694DBA40B" modified="2014-06-11" version="1">MESSPGSTTSLLRTIVGTSLRRLGGWISVAHLVELGAAVGLPDARTRTALARIKAKGLLDAERRGGVPGYAIAAGAIPMLERGDRRIFRPRSMGDEDRWCLVSYSVPEESRDLRHQLRRRLTWIGCGAVSPALWICPEYLTDEVEQILADLGLAGNATVFRAEVRGAVDAARWWDLDAIRARHEAFLVACAAPVGHTAEEAFRAWIHGLDAWRIIPYVDPGLPARLLPGDWPGHRSVAVFLELRDRVLPRAQAYVDGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS11</accession>
    <name>A0A010ZS11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850791.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2524"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458406" evidence="1">
        <location>
            <begin position="32"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="430" mass="45556" checksum="A5BB9C38CCF63FB6" modified="2014-06-11" version="1">MFKRRIAAVAAAGLLASTLAACGGGDSGSDAKTLTYWASNQSISLDKDAEILKPELAKFEKQTGIKVKFEVVPWSDLLNRLLAAATSGQGPDVVNIGNTWSASLQATDAFVPFDDATIEKVGGKSRFVPSALAAAGAEGKPPTAVPIYSLAYSLYYNKKMFADAGIAKPPATWEELVADGKKLSKGGKWGLAQEGAHISAHSHHAFTFSQQYGGEWFDKSGKPTFGTPQNAQAIKRYVDFLAADKITNPGNAEYAQNESVNDFANGKAAMLLWQAAGNQLALHGMKPEQWGVAPVPFPATAPAGGKKVNSMVAGINIAIFKHSKNQEGALDFVKFMTSDEEQIALNKAYGSLPSVTTVSDDPAFSGPEQKVIAETLATTAAPLPQVPEESQYETLVGNVMNDLFAEAAKGKSPSVADIEKKLKTAEEQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT53</accession>
    <name>A0A010ZT53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849245.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101456_0_0_11"/>
    <dbReference type="OrthoDB" id="2200715at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="25957" checksum="9F48D27C66737B66" modified="2014-06-11" version="1">MLVAAVLAGGLAFTGWQIGQMRADGGPVQLAERGPLPQDPTTWPTSSGDPNEQSQQGAIAPGPPPESVEATGSPTASPSPVPVPTGRWAGMASVTVTGGDQGCRANTKTFRTPAVLRIEAPLRGDGNAVRVTFESDDPAAEGSFRVASSVPSTGRAATRWWVLSGNGAGGFVGRLYRPAEDPVRDAGEIDNLLFATRSLDQQCGALLSAPLSFPLGSGSSLRLTGQGAQRSVLVTGRTSDTTRSFQIAWAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT78</accession>
    <name>A0A010ZT78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851378.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_4_11"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="26930" checksum="45DFCF4735494598" modified="2014-06-11" version="1">MNSFLTTGHAYDGYMGRYSRPLATLFADSAGVAPGWSALDVGCGPGALTRVLADRLGPERVSAADPSPPFVAECAAALPGVTVRAGRAEDLPFGDAAFDCALAQLVIHFVADPHAFGRELRRVVRPGGVAAACVWDFAGGMQMLRLFWDAALTIDPSAPDEARTLKFGRDGEIAAWLAAAGFTGVTETVLSVSSTYASFDELWNGYLAGIGPAGVYCVGLPDDQRTAVRAELFRRLGSPTGSFTLSALARSASGRNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU27</accession>
    <name>A0A010ZU27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569946.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1764"/>
    <dbReference type="HOGENOM" id="CLU_320496_0_0_11"/>
    <dbReference type="OrthoDB" id="48881at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="924" mass="98984" checksum="AD53012826E75BD9" modified="2014-06-11" version="1">MSVDVQLARSYQHPVLGGRTVVRLVPATLAEAEDLSMEFLGFSAPLRSAEVGTVARQALGFPAWALVNDPANGHHALALVKEIERLARTAKSRVGPAKEGFDELGRRLGAAVPHFLPTYYEEAGRAFLAADSPSYGAMMFGKAREAEQTYALAVDEEREHAVFLEFALAGALTVKALTAHARALAARSEPAEAYSRFRRLCVERTLGGLAPYAGMAADLRRLAKAAGLDQAEADADVLRELLSAPTLQKAPEPFWKAYRAALVRLGAGEPAVRGRLLTFFPENLGTTEWLELLEAAGATEALTAAAGTVDAAAEPTDGVAGWFERAAKHRDSRYWRASRRSTALCALLERAASRLRADGVALRIELDWQSDLDLYDTALALGLAVADPSDEFQVSVDQWLDDDNDGRRDLAAFAADPRFLPALVTAVEGALPRRPSPARVEAVLAASGLRVAVAHFLDDLAEQIVRQGLPTLEAQLERLDKVVDGRLLALNPAAAERIRAHDLAPVLGRTLRSGLVDEFGWPALEEYVASSVPAPRADDEEQQVTQVVQWPHLILRHGLQAAVLDGSGVVSSHHLRIPKDERGYLWLTAFRYVDGQLLVSWDTGPNRSAYWSGTPSDVLTELPFDAWHQNDQSLPLPGGGRTSGGRPLRVGDRSHHRYDRVFSDGVSYWAADEETLVEYDPATGERGRASMPAFFEAGAVDGEPIDVSSSMLRPLAPVGGPLAPAGGSSPLGQVDGLVGWRVRTAADGVSVGTGIDGRTVRLAVGDEGTLVNAIRFPGSDAVFGLLRRERWRENTLTVVGEDGFVVSQVGVGARRDTFAAGTPLVPRAAGWHHLRPRDLVGSAALRAVTDEQAATLLAAASRDHAAAVAADAGEDGSARRAVAAGAAGAAWMGRPGPGRRLSGPRGRSSARRWRPCCPRSRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV55</accession>
    <name>A0A010ZV55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852456.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3738"/>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_11"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31912" checksum="FD5A8C9AFCBEAA47" modified="2014-06-11" version="1">MDVPSDATDLESAAQVFADVRPRLFGIAYRMLGSVAEAEDLVQDVWLRWQLYDRSAVRNPAAFLATTTTRLAINALTSARARRETYVGPWLPEPVDTSADPYLGAERGEALEFAALLLMEKLSPAERAAFVLREAFDYPYAQIAEILQSSEPAVRQLVSRARKHVAGERRTPVSPAAQRELLAAFLDAARSGDLAGLERLFAPEVASVSDGNGGYRVARTVIVGATRVAKFLTAISGWFWDDVEVGWAQTNGQTSAVLRRDGRVYGVLAISASADGVDQVLWMVNPEKITAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV81</accession>
    <name>A0A010ZV81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570603.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459191" evidence="1">
        <location>
            <begin position="27"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="446" mass="47097" checksum="6D698A3FCCC55949" modified="2014-06-11" version="1">MIRSAKTLIVAAVATALTALGGTAQAAPPGWQPCPAGDVPLECTRVTVPVDWSEPAGDTITLKVSRLRATGTRLGAVVVNPGGPGIPGTQFLAAAGARFAALRASYDVVAWDPRGVGGSAPISCPGPRPDSGVPATVVERERFERETAAWARRCRAAVGPLFDHVDTVSTARDLDRLRQVLDEPRLNYYGGSYGTRIGQFYADLFPQRVGRLTLDAVVDTTSTNGPFVDGATRAKEEAFTDYLDTCASRPGCPLKGMTPARVRSWLIPRITAEPAVGGEIVGYLTSPADWPAIDEHLTRVRAGTYHPPADDEAGDVLNTDVNCLDLPDHRTAAQVIADSRRAAARYPLFGRLMTATTVCNVWPTPATYHPHRITSPTPILLVGTTHDTATPYDWAVRTAGNLGTGRLLTRDGTGHGAYGTGPCVTGAVNRFFVTGALPAPGTVCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV95</accession>
    <name>A0A010ZV95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16811" checksum="9B21F3657F9C610B" modified="2014-06-11" version="1">MFTVTRMNHIGVPVSDLDRSVRWYEDVLGIAANGVTISADNAALGAVLEVENPAMRAAFSLAGDNVLLELIQYDRPTPKPFTGRNCDVGMMHLCFEVDDLDAAVRDLKERGVHLNADPVVLAAGDGIHPGALAGTRILYLRDPDGIQLELFELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVC6</accession>
    <name>A0A010ZVC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2235"/>
    <dbReference type="HOGENOM" id="CLU_066396_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="28644" checksum="298822B9177BDEB9" modified="2014-06-11" version="1">MRQNFGMGGTAEVPLGGRVTAGVVRVGDTVRRPAGPWTDAVDALLRHLEQVGFRGAPRPLGRDERNRQVLEYVPGETGDPAGTYSPSELRPIGAFLADFHRAVADFVPPADASWNRVIPPDRDELLCHHDVAPWNLVRSPRGWVLIDWDTAAPGSRLWELAYAAQTLAGLRPDRPVDRAAERLALVVDGYGLADADRPALARMLGPRARAMYDLLCHGAARGEQPWLRLWREDGEHWRTTADYLDHHVDHWIRALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVK2</accession>
    <name>A0A010ZVK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850479.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2305"/>
    <dbReference type="HOGENOM" id="CLU_188250_0_0_11"/>
    <dbReference type="OrthoDB" id="2030858at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="82" mass="9225" checksum="7F9F4EDCDFE2691A" modified="2014-06-11" version="1">MTNRLFVLDVPENIPVVAVAEALPQVTIDRVGPYFVLESDTPISIDRRSTGVRHAVWYSCVAGLAGWRIAQWDKDALRTEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVR5</accession>
    <name>A0A010ZVR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850573.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2365"/>
    <dbReference type="HOGENOM" id="CLU_056776_1_1_11"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20376" checksum="E8D85743272EDE35" modified="2014-06-11" version="1">MTGPEIEHQQGAGDPDHFQRLWTPHRMAYIKNDTKPDADACPFCVMPTLSDEDGLIVTRGRTVYALLNLYPYNSGHLMVVPYRHVPDYTDLDVNEVAELGALTQDAMRAVRKVSGAHGFNIGMNQGSVAGAGIAAHLHQHVVPRWGGDTNFMPVVGQTKVLPELLGETRALLASAWPPVAARSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXB1</accession>
    <name>A0A010ZXB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mak_N_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851325.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2948"/>
    <dbReference type="HOGENOM" id="CLU_108515_0_0_11"/>
    <dbReference type="OrthoDB" id="1568624at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="19224" checksum="002DB73ADACCF4D8" modified="2014-06-11" version="1">MAIVHNTTLVPSKLELLSEWLPRQPWYRGSGTPGLTKAGGFRLDDPAGEVGIEVMVVVDAASPDVDAYLVPMTYRAAPADGALIGTMEHGVLGTRYAYDGFTDPVLRAELAALVRGEVQPQAQSESDTVDPTVRVGLRPAVTDVEIHRLLTTSEAPPQPGEVSVPWRTAGGGSARGVVALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXX8</accession>
    <name>A0A010ZXX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169118_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459212" evidence="1">
        <location>
            <begin position="30"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="229" mass="24397" checksum="CCF3CA8AA27D2B17" modified="2014-06-11" version="1">MIRVRARIFALLATAVGMLAVLAPSAAAAAEDEPPLSATRQPSQFNWADATIDLPWTAAVLKDGTTCPGGRINFTPSEENPAYGQATANGMTYHITLREFGNVSGTTGLSSPEAIVSIGCGYTSGTSTIAASYEYLFYFKWSGSGNSSKGAFYPKVRDFITSSDSSGSSRYLVQLIDGTGPVDGQPGKVTVRHFLYQVGTHTRTFTWTDEGFVANTPLIRYPEADTAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYD2</accession>
    <name>A0A010ZYD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851879.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2286815_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="10515" checksum="EE35B3040B4BBD72" modified="2014-06-11" version="1">MTIVDVLDDLARVAAATTPDQYALATPSAGLDVLALRRHLTGGLIYFEAAFRNPRAANNGADPHTYSGPDDLEAVLARLSGTLREALDAGATAAQALAFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZI1</accession>
    <name>A0A010ZZI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570612.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3796"/>
    <dbReference type="HOGENOM" id="CLU_023205_5_0_11"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="35057" checksum="98E7E810B031AF32" modified="2014-06-11" version="1">MIPGTLGLGGAPLGNFAAAMDDDRARRTLDRAWDRGIRYFDTAPHYGLGLSERRLGAALRERPRDEFVVSTKVGRLLVPRVPPREWDDDGFLVPGDLERRWDFSPEGVERSLRESLDRLGLDAVDILFAHDPDQAWGSAARESLASLARLKQAGLVSAIGIGTNSTAGLSTLIGEGLVDVIMLANRYSLLEASALETVLEPAREAGVAVVAVGVFATGLLSTARPAAGATFEYRPADAAVLDRTRRIAEICEDHGVELPVAALAFPLLHPAVAAVAVGMRSPGEVDENLERFAADVPDGLWRDLVAAGFLPAAAVPTRSPGGRPGDAAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAM4</accession>
    <name>A0A011AAM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="53919" checksum="A23242126728F2B0" modified="2014-06-11" version="1">MIGGRYRVEAVVGTGAMGTVWRGYDTRLHRPVAVKEVNLPNTATDDQRTLMTRRAMAEARHAAKVSHPNIVAVHDVVAERGMPCLVMRLVEGRSLGETVRSTGPVSPVQTAQIGIALVDALAAAHRGGVVHRDVKPSNVLLTDDGEVLLTDFSIATDSMRGTMSAGSGALGSPGYIAPERLNGQTTGREADLFGLGATLFCAVEGFGPFDRHDPLAALLATATTPHPAPKRAGALAPLLDALLAKEPSERPGLAQVREALSAVARGEEAPTTEFAAVAPPSRDETPTVVVANTSGDASEAPRPTSADGVDGEGPRPGKPMHAAPRSGRRRKMLIGALAAAVGAAVVATAVVLSGGGDNTEDGSIRAAESLAAPPPGELASALPSASDSASASASASVSASASATPSASKAASPTQSESPDPVGQVTGAEMSVSPKNYFGSCANPVTFTVNLTVSVSDGPTDIRYTISQAPGDSEIAGGAGSVPDADVPAEFSDQVALDFSQGSRTYAVQVAVELPTRFSPVPAQISVLCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAR5</accession>
    <name>A0A011AAR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="33059" checksum="5155E2E144FE65C7" modified="2014-06-11" version="1">MATRCHGPAVVGEHAPTLRRRELAARLRALRHESGKTIEEVARELLCSPTKISRIETGRRGAVLRDVRDLCRLYDVSPAEQEQLMSLARASKERAWWQGYDIGATYRTLIGLESAATAISDYQPTAIPGLLQTPDYARALIEGAGERRTQEIDEQVKLRINRQRILDRPDPPYVSFILDEAATRRLVGGHEVMAEQLDALLAACERPHISLQVLDFEAGAHPGLPGSFGIVEIEESPASSIVFVEGHHGDFYLEGSVDLKRFRRIFDQLRSIALSPKNSVDFIAAVRDRIRPPEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABN4</accession>
    <name>A0A011ABN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deazaflavin-dependent nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848082.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.455"/>
    <dbReference type="HOGENOM" id="CLU_114921_1_0_11"/>
    <dbReference type="OrthoDB" id="1622823at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="16305" checksum="3F386261EB071D83" modified="2014-06-11" version="1">MPLTGEYEPSPSEWSREQAEKFEASDGAEANTMRGVPIILLTSVGAKSGKLRKAPLMRVEHGGEYAVVASLGGAPKNPVWYYNVVKNPHVELRDGAVVKDYEAREVHGAEYDTWWERSVAVWPDYAEYQKKTDRKIPLFVLTPIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABQ3</accession>
    <name>A0A011ABQ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barbiturase</fullName>
            <ecNumber evidence="3">3.5.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Barbituric acid hydrolase</fullName>
            <shortName evidence="3">BAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the hydrolysis of barbituric acid (2,4,6-trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>barbiturate + H2O = 3-oxo-3-ureidopropanoate</text>
            <dbReference type="Rhea" id="RHEA:18653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58775"/>
            <dbReference type="ChEBI" id="CHEBI:77938"/>
            <dbReference type="EC" id="3.5.2.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Inhibited by cyanuric acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; uracil degradation via oxidative pathway; malonate and urea from uracil: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The monomer structure is formed from three repeating units (RUs) that share the same structure as one another. The monomer and the active site possess nearly threefold rotational symmetry, to the extent that the active site possesses three potential Ser-Lys catalytic dyads, but one of the 3 active site surfaces varies in composition suggesting it is involved in confering substrate specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cyclic amide hydrolase (CyAH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848115.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.476"/>
    <dbReference type="HOGENOM" id="CLU_808206_0_0_11"/>
    <dbReference type="OrthoDB" id="984718at2"/>
    <dbReference type="UniPathway" id="UPA00582">
        <property type="reaction ID" value="UER00644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047694">
        <property type="term" value="F:barbiturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01989">
        <property type="entry name" value="Cyc_amidohydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014086">
        <property type="entry name" value="AtzD/Barbiturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043008">
        <property type="entry name" value="AtzD/Barbiturase_RUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043006">
        <property type="entry name" value="AtzD/Barbiturase_RUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043007">
        <property type="entry name" value="AtzD/Barbiturase_RUC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09663">
        <property type="entry name" value="Amido_AtzD_TrzD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02714">
        <property type="entry name" value="amido_AtzD_TrzD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="RU A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="RU C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="39635" checksum="036F164F33082630" modified="2014-06-11" version="1">MPEAIEVRKVPILNVSDASGLAQLIDDKILDADRVVAVIGKTEGNGGVNDYTRIIADRAFREVLVAKGTRSADEVKQIPIVWSGGTDGVLSPHATIFATIPRGEEEATDDPRLTVGFAMSDVLLPEDIGRVAMVEKVAAAVKIAMERAGITDPADVHYVQTKTPLLTIHTIRDAKSRGKTVWTEHTHESMDLSNGTTALGIAVALGEIDMPTDADVMHDRSLYSSVASCSSGVELDQAQVVVVGNARGVGGRYRIGHGVMNDALDADGIWDAIKSAGLSLPDRPKASDLDGRLVNVFLKCEVSQDGVVRGRRNAMLDDSDVHWHRQIKATVGGVTAAVTGDPAVFVSVSAAHQGPDGGGPVAAIVDLGAGDPTGYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADF9</accession>
    <name>A0A011ADF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848873.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1132"/>
    <dbReference type="HOGENOM" id="CLU_000022_35_2_11"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1719"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="2154" mass="226998" checksum="0B5145198B1DAFE0" modified="2014-06-11" version="1">MNLASWLAARIGVTDADLDRPFGELGLASRDAVAIVGELEQLLGRPLPATVVWEYPTIELLAGHLESGVSVNKGLPGLEAAGSPVRGATGEPARSEPIAIVGLGVRFPGDVRTPAAYWDLLASGRSGVRDVPSGRWEQFSDGSAASAAVLAGLTRWGGFLGDVSGFDAEFFGITPREAALMDPQQRLLLEVAWEALEHAGLSLRGTATGVFVGASGTEYGHLTGASLSSIDAWTATGSALSIVSNRLSYLLDLRGPSVTLDTACSSSLVAVHQACQSLRLSEVDHALAGGVNLLLSPSVTATFDAAGALAPDGRCKAFDARADGTVRGEGCGVVVLRRLSDARRDGNRVLAVIRGSGVNQDGRSNGLTAPNPASQEALLRGVYAGLSGTEIDYVEAHGTGTLLGDPIEARALGAALGAGREPDRPLLIGSVKTNLGHLEAAAGVAGLVKVVLAMVHDRLPASVNYSTPNPHIPFDSYRLEVVSSSRPWPRYSGVARAGVSAFGFGGTNAHVVLEEYRSVPRRRSRGARGPALVLPLSGRSPERLRASAGALAEWLEGRPVGLDEVASTLAHHREVGRSRAAVVVSAVDSAGRGSAVEALRRVAAGEEWPGVVTGPERAAPPARGPVWVFSGYGSHWAGMGRRLHHEHPVFADAVRALDPHFVTYAGFSLATLVETGAKPRDLATIQIATFGLQLALAELWRAHGVEPAAVIGHSMGEITAAVVAGALSPEDGVRVISLRSRLLVEAGQRILAGGGDLGATAVVDLAAAEVDALAPRFPGVGVAVYASPDQCTVAGDSTQLAALVAHVESLGRAARQLDVRGAAHSPIIDVILDDFRSGLAVVKPSDVGVAIYGTVLADPRETPAFDAGYWAANVRRPVRFTQAVAAAAEDGHTVFVEISPHPIATVPVARTLAAAATTAPVLAWTLRRDTDDAVTFATNLATLHVHGVPVDLRVPRTQLVDVPTAPWRHQRHWVETRPRPTGPHPLLGSHVEQPGQHVFRASVGTDAAGWLADHRVHGVVVLPGAAFAELALAAGSVGFGVPVARLTLTDLDLERILPLGPTTELTVTLTDAGAVEFWSRAATDDWLRYATATVSTTATPPAAAAPSDVAGEAVDLYSRVPLAGRSYGPAFRGLVEATLRERTGGAAGRVIPPDAAGRVILPDAAGGAAGFHLHPAQLDALLQTLAVAALAHERPDDSIYLPARIGTLRTAGPLPGEVFAEATLAPQGENAALGTVLVRDREGALIAEIRDVYLRRADRASVPVPLGDKLFAAVWEPAPSPSAERLAGRWLVLGTGAHADQVTHLLAEAGQQVVRDEAEATDVLVIDPRTPGPDPTGAERLVMTVAGTARGLGDRARLWTATVRAAAVVDGEVADPGAEALRALIRVLGVEHPELTATFVDADSAGSLVDELLVAAPDTEVARRGPRRWAARLTRVSVPATPRSHPAGPESDGLEPAGTLVRPGSYVISGGLGGPGVLLAEWLVARGARRVVLNGRRGTASAEVAATVERLRETGAELEVVPGDIAEPGVAEEMVGAATAHGLPLHGVVHAAGTRADQPISTLDAGSLHRVWSPKVTGALRLHEATVDHPLDWFLIYSSAAGLLGSPGQAGYATANAWLDGFAEWRRARGLPATSIQWGARSQVGGAKDTTNPLLEPISPAEGLEALAAILASGRTVTGVTRLDVPQLLALFPRVAAIPYFAHLVPDEPAPDRRDGVAENWTQLIDRLTSRVGGIMGFRPDELDASVPLTELGLDSLMAVRAKNAVEADFGVQLPVRMLLQGASLNDFVTHIGQELGFAPRARTPLRRTPLAGRDHTERLVQRLLKRTVDVDEPLDLDHGARERLHEQLRERVPGLPHDTAALFAAPTIAAIADLVRPFSENATSVVRPLRAEGRRRPLFLAHPAGGPAGVYQELAGLLHPDQPVYGLERIDELTTIEAKAARYLELVRELQPHGPYRLGGWSLGGCVAYEMAQQLRAAGEEVAFVAVIDTIVPLPPDPAKSEQERVTDRLMVFLDYLHDTYGIRVDIPYDELFRLDDVGQTDLLTKLIADAGLGLSKGVLQHQRDSYLDVRVAERYRIQPYDGRVVLYRATEAVDVIAAQDPRYIRTDESLGFDEWCSDLEVVPVPGDHLSLIDRPNLDVLASHLDGVLDDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADV8</accession>
    <name>A0A011ADV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849035.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1272"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="31234" checksum="6E7F918F44C65870" modified="2014-06-11" version="1">MTRDRIENVVLGVARWVTIVVLTVVSLFPFYYMVLLSVRLIQDVQLSPASIVISPGEIVFDTYQEVLRSVDAGGQGFVRLIGVSAAVSIATVIVTLAVSVPGAYAVTRLRFAGRRQVDALFLAIYLFPAIVLAIPLYVVLSRLGLRGSLVALVLVYVAQTVPVTLYMLRGYFETIPVSLEEAAQLDGCGRLGVIWRVSLPLSRPALAATALYVFMIAWNEYLFALLFLVERRDRWTVSLGLSQLAGTIEIPTTVLMAGSVLLTAPIVALFFAGERLLVEGLTGGAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE25</accession>
    <name>A0A011AE25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674987_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="157" mass="17164" checksum="779E115D9946B8FB" modified="2014-06-11" version="1">MQGQRTLRGWMYVLVTLACYLAFCLVGLLMVLPVDYGGGEASIGLTGQILGACILVVFAGPLIRTPFLRVVLSDEGIVVHNPVRTRRYTWGQIARCEVGEIGGNLVPLVAPILTLADSDESFGIRFLESFWLFRKPEQTRAGRLAATIEARRLSAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE27</accession>
    <name>A0A011AE27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692553_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16825" checksum="3FF21E4CCD34349B" modified="2014-06-11" version="1">MMHGLARYGSPLAATGLDRERPVAPNPSDLLDVPLSSLLANELDLSQRAHATRAGYLPDELVAEDFLYLLALRTAISRALSWGSQADVREAIEGGAKWTDVAIARGNTTAEARAEFLHWVNAQAALWDSGPTPTGLRFGLEPEHRRAVRALAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE87</accession>
    <name>A0A011AE87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CryarDRAFT_1417</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849189.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1392"/>
    <dbReference type="HOGENOM" id="CLU_038423_2_1_11"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EXG80346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="29073" checksum="7C85A7AD0F1815CB" modified="2014-06-11" version="1">MPEGHTIHRLARRHKRLFGGAVVGASSPQGRFEAGAAGLDGLTLRGTDAHGKHLFHDYGDRWLHVHLGLYGTFTDGTGEPPAVRGQIRLRLTGGRKGPVWAELRGPTACEVLDDGARDALLARLGPDPLRPDAEPDLAWRRVSRSRTSIGALLMRQDVLSGVGNVYRAEALFRGGIDPYRAGRDVSRAEWDAVWDDLVVMMTDGVRAGRIRTLRPEHKLREPAGRGAGRYVYHRAARPCRLCGTPVRTAVVEGRNLFWCPLCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEV5</accession>
    <name>A0A011AEV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861323.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1622"/>
    <dbReference type="HOGENOM" id="CLU_046006_13_1_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="13987" checksum="FF5CFAE55B9D46CD" modified="2014-06-11" version="1">MRVTASAVSLNVDDVPASSGFLQKHFGFREEMSADGLSSLKRDDAAMNVIYLRRGLATRPSDFRDTGAAGVLVVFVVDDLNAEAERLRAEGVVLTHELTEEPWGERFLQVTDPNGVIVQLVEWVTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFB9</accession>
    <name>A0A011AFB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar basal body P-ring biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849747.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1773"/>
    <dbReference type="HOGENOM" id="CLU_078491_1_0_11"/>
    <dbReference type="OrthoDB" id="1887172at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="22509" checksum="81D8E2B8324AD12E" modified="2014-06-11" version="1">MSHTATQTPVTSGPVPAPRVVGQRRVRTGHLGLAVALVAIGGLLAAFAFYAATRTGDFLAVARPVAAGATITEADLAVVQVNSAAGLTPLAASQRGSVVGKRAKVSLVPGTLLTADQLTDTELVGPGQQQVGVGLKPEQMPASQLRPGDKVRLVALAAPNSSSTEESSSPEVFTATVVGASPRRENQERTVVYVAVSESDAARVVELAGAERLGVVLTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFM8</accession>
    <name>A0A011AFM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130568_1_0_11"/>
    <dbReference type="OrthoDB" id="1572823at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_7" evidence="1">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="13739" checksum="53EABC18E0225BF5" modified="2014-06-11" version="1">MSTFVPQKLHLRPDLFAIERHDSEDIVGSADWVALVRAPQGLTVIRTVADAADGWRAFQGQSSHELDVPGMLLSILAPLGEAGLPVFAASTYDADLVLVPASHAEKAATVLSTAGHEVHEDRDHHESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGB9</accession>
    <name>A0A011AGB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850224.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2132"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="30104" checksum="AB2D06BABA6F5B59" modified="2014-06-11" version="1">MPNTLGEYLRARREQVDPASAGVRTTGLRRTPGLRREEVATLAGISADYYLRLEQGRDRNPSPQVLESLARVFRLDATATQYLLSLSTARPAPRRARRETVPIGIRQLLDVINLPAFVENRMFAVVAANRLATAVSPNISPGVNRLRALLLDPEEQALFTDWEQAVQGMVAGFRASVGTHLDDPDVARLVDELSRTSPEFRRLWAQHDVAPLAGGSFRLSHPQVGPMDLRREKLPLQDTPGLILAIYHAEPHSETARSLELLGSLSVTPDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGG8</accession>
    <name>A0A011AGG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2173"/>
    <dbReference type="HOGENOM" id="CLU_146028_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458705" evidence="1">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="12872" checksum="79299F79F1738530" modified="2014-06-11" version="1">MTVKRKIVGRTLALLIATVAALATGGVVATPASAGNITGRCTYTSSEPVLRSGSSGTAVRQVQCELNYAMTGVADIAVDGSFGPITDNYVRRFQSCIGLPVDGIVGPNTWKQLNHWAASVGFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH02</accession>
    <name>A0A011AH02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725698.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_2_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="82"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_MalT" evidence="3">
        <location>
            <begin position="498"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="717" mass="79243" checksum="8C68C2EC31AFFF94" modified="2014-06-11" version="1">MSGANESGSRNELSGSTSSSVQAQTINGPVHIGSYLSVQDLPSPRQLPPDIPHFIDREETLRRLDLKLSVGVRSADQPVTVVISAIAGAGGIGKTAVAVHWAHRVRHQFPDGDLYLDFQAYGKGPAISADEALDAFLRALNVPTERIPQTTHERAALFRTICSGRRLLLLLDNVGSAEQVRPLMPASTTCVVVVTSRNTLRGLGVREGASRMQLDALAPDAAARLLAEIIGAERVEAEHAAAAEIAAYCSFLPLPLRVVAERVLDRPGTSLTEISHELSVERERLDLLSRSEDDLAAVRTVFMWSYQNLRIEERIFFAYLGLHPGVEMSVDACVVLSGVERGRVVLLLDSLTSSNLIQERDTKRHRMHDLVRLFAAERAEADLTLERRRNALRNIYLWYLTRSWAAYRIIVPQGWTFPIDESVDLPGARSFRDLPDALAWCETERVNLVDSVRQSKRFGLVRVCWQLAVSASAFLERGSYLENWVQVSQIGIDAARDDADMTARTHLILLLADAHRHRRDFELALERYSEGYELSLQNGDRWRAAFAVRGRAMVLQEKGEFQQVLDAAERARELFEQIGESRGRGLALLSIAGAYNGLRDYQRAGEYCQEALAIFEEIDNRWSIAAARLELGRSNVGQGAPDQARAQFDAAADLYGGLGDRQARAEALAESGRLALSVGDVEQARTTFTEARALFEAMGDPRAASVDAQVKSLSPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHC5</accession>
    <name>A0A011AHC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850730.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2496"/>
    <dbReference type="HOGENOM" id="CLU_017810_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="291"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="499" mass="55190" checksum="32D4BD7FEF5A9EF9" modified="2014-06-11" version="1">MLQASLTIDPAFTVGDVDPRLYGSFVEHMGRCVYTGIYEPGHPLADESGFRTDVADLTRDLGVPLIRYPGGNFVSGYRWEDGIGPVDERPTRLDLAWRSLETNRVGVDEFLPWARSVGAETMMAVNLGTRGIDAARDLIEYCNLPGGTYLSDLRRKNGSAEPHGIRTWCLGNEMDGPWQIGHKTAYEYGRLASETAKAMRLVDPSIELVACGSSNSSMPTFGSWEATMLGETYDQVDYVSMHAYYEQRGDDRDSFLACAVDMDRFIDAVIATADHVRAVGRRKKRLNISFDEWNVWYLKRFEGEANLAIREAPPLIEDVYSVTDAVVVGTMLNSLLRHADRVKIGCQAQLVNVIAPIMTTPGGAAWKQATYHPFALTSRYGRGTVLRVEPASPRHETKWLGEVPLLDAVAVQNEDGVSLFAVNRSQTSPMTVDVDLRAWPGYRVASHVMIADDDPEAVNTAENPERVVPRPVEVPAVDGGRVALELPALSWSLVRLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI38</accession>
    <name>A0A011AI38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="34232" checksum="A017DF87B2033553" modified="2014-06-11" version="1">MISSRRWVALVGIVVVLALLCLVSIAVGARSMPLGHVLDALFTPDRAPDDELAIVRGLRVPRTVLGLLTGASIGLAGALMQGLTRNPLADPGLLGVSAGASLGIVAAIGILHIGDFYGYIWFAILGAVLASALVYVLGGLGQGGATPVKLALAGVGVTFFLGSVTSAIVLASPAALNRFRFWSAGSLAGQDTGTIWRVAPFLVVGIVIALCSAPALNTLALGDRMARALGRRVGLVRITGAVAVTLLAAASVAVTGPIVFVGLVVPHVVRLLTGPDYRLLLPFTLVLSPVLLLAADVLGRVVVRPGEMQVGVIVAFIGAPFFIALVRRRSVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK98</accession>
    <name>A0A011AK98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570489.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19791" checksum="2A9CE989FDE9C128" modified="2014-06-11" version="1">MTTTTLNRGSVVPPAVRAEHMREIHRNNGNALLHFLRGLVSPGTAYTAEDLVQETMLRAWRSLDAVPTEPASQRRWLFTVARRLAIDVHRKRQSRPAEVSMRDSEPTATGNGAAETVVARLTLRQAVDGLSPAHRTVLDEIYVRGRSLDETATHLGVPVGTVKSRAHYAVRSLRAALLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKU3</accession>
    <name>A0A011AKU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852482.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3746"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="30186" checksum="36EC24ED9EED76E8" modified="2014-06-11" version="1">MTSEPLSLGELLRSRREHLTPTDVGLASFGRRRTAGLRREELAQLAGVSVDYITRLEQGRSRTPSRQVVAALARALRLSRTEADLLHRAAGLTPPGSGIVSHYVPPGVRRMLTRMSDLPLAVFAADWSLLDSTPLWQALFEAPPVDADPDQNLLVQVFIDDSVSGIATAHGGPEAFERALVSDVRRSAADYRDDARFREFVADLRARSPRFAALWDAGHAAAHQSLVKTVHNSVVGDVVLDCDVVVVPDGQIKVVVYSTSPDGPDAEKLDSLRLSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL10</accession>
    <name>A0A011AL10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852575.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3810"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="34361" checksum="B7BF070446F2B16D" modified="2014-06-11" version="1">MRAFVLHGPGKAAVEDVPPPVAVPGEVVVDVERVGVCGTDVEFFTGEMAYLHEGHSSYPMRLGHEWAGIVAAVGDGVDPAWVGRRVMGDTMIGDGTCRRCRRGHQHVCEHRQEVGIRGGRAGALAEQIAAPVTSLHAIPDSVDPVLGALVEPGGNAYRAARAADVGPGDRVLVLGPGTIGLLTAMFLRAAGAEVHLLGRDEESLAFPRGLGFADAWTEPTLPALPFDAVVEASNAAHLPARALALVEPAGRLVYIGLAGSPSLIDTRTLALKDVTAVGVLSASPGLDATIAAYASGVVDPRPLVAATVGLDEVAAVLAGHRPAGAGPGPKVHVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALI2</accession>
    <name>A0A011ALI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852689.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_10_0_11"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="156" mass="16409" checksum="235144A558D76408" modified="2014-06-11" version="1">MSAALVALVTAGVAIGLAAYWARRRYVVVTVLGESMVPTFAHGDRVLVRRAPLARTRTGQVVVAAWGTPVPGGPRPLVIEEPVAGEPPTIDPWVVKRMVAGPGDPVPETIGAKVADLQVPPGRFLLLGDNVAASADSRQFGYVHAEYLLGVVVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALY6</accession>
    <name>A0A011ALY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853084.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4152"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="33364" checksum="DAAA9B3102DF7321" modified="2014-06-11" version="1">MRAVQITSLNGPSALEVVTVDEPAAGPEDVVIDVHVAGVTFPEVLQSRGEYQLKPPLPFVPGSEVAGVVRSGPGFAPGRRVAAFPALGGFAEVVTARPAQVFPLPDAVSFEAGAALPMNYLTVHFGLVRRGRLRAGETVLVHGAAGGVGTAAVQLASALGARVIAVVSTEDKIDPARKAGADEVILADGFKDAAKELTGGRGVDVVVDPVGGDRFTDSLRSLAREGRLLVIGFTGGEIPQVKVNRLLLNNISVVGVGWGAFWVPQPNYLQEQWSDLAPLLAAGKLEPVLGRSFPLEDASLALRELDERRAIGKVLLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFX0</accession>
    <name>A0A010YFX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.140"/>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="106" mass="11484" checksum="D233E0780B1645C6" modified="2014-06-11" version="1">MKDSVRGHLDAMLLAVLEPGPLHGYAVIEALRQRSGGRFDLPTGTVYPALRALERAGYLSGSWSTVGGRKRRTYALTGSGRHALSAERTDWRDFSRALNATLAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH14</accession>
    <name>A0A010YH14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.592"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="24085" checksum="FCEC4F7E92F29F59" modified="2014-06-11" version="1">MSDDDGEIRVLLADDQALVRAGFRALLDAQPGITIVGEAKDGAEAARLADALTPDVVLMDIRMPGVDGLEATRRITASVRLTATRVVILTTFDLDEYVFEAIRVGASGFLVKDTEPADLVQAVRVVARGDALLSPGVTRRLIAEFAGHLRKPAPTGQLDVLTDREREVVALVAAGLSNAEIADRLVVSPATAKTHVSRAMAKVNARDRAQLVVLAYETGLVRPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHP6</accession>
    <name>A0A010YHP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848554.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.814"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="31138" checksum="3258C02ABDB0B706" modified="2014-06-11" version="1">MNPRTEIAAFLRTRRARLRPADVGLPDGIRRRTPGLRRQEVAQLAGMSIDYYIRLEQGRGPNPSRQVLSALARALLLTRDERDYLFRVAGETPPVVAGPARDLTPAIRVLLDSLTDVPAYVVDASYTVLAWNELATHFLSDLSLVPEDDRNMIRWMFRRSDGDPHRDDESTRAFNRSTVADLRAAYARYPGDPGIERLVTELLGTSKRFAELWAAHDVEERRRIVKSVVSPQLGRLEFECQVLHVPETGQRIIVYCPEPGSPTAGIFARLSRVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHR3</accession>
    <name>A0A010YHR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848586.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.835"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26738" checksum="C4F847EEEE8FDC12" modified="2014-06-11" version="1">MTTPLLEARGLNRSFGHVRALRDVDFEVYPGEVTALIGDNGAGKSTLVKALSGNLELDSGELLFEGAPVRITTPQQASALGMEVVYQDLALAPHLSPVQNMFLGREIPRRGLLGKLGFLDEKAMRTKAAAGFAELGGTVRALGAPVGSMSGGQRQQIAIVRAITWAARLVFLDEPTAALGVVQTRNVLDTIKRVRDKGVAVVLISHSMPEVLEVADRVQVLRLGTRVTTFDAAGTTVDQLVGAMTGSLEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI93</accession>
    <name>A0A010YI93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848753.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1026"/>
    <dbReference type="HOGENOM" id="CLU_048408_0_0_11"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458849" description="DUF58 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="3">
        <location>
            <begin position="192"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="436" mass="47054" checksum="7C6D870881B9E4C3" modified="2014-06-11" version="1">MITGRVVLLCVAGAVVSAVLPWHATTAQIWLLVLALVCVVDWFLAGAAGKVTFRRKGATTTRLGESAVVTLVATNTGRRTVRARVRDAWVPSAGASPYVHDVVLKPGATERLDTTLVPTRRGDRPAVAVTVRSTGPLGLMYRQTRRRAIRRLTPAWTMRTLPPFASRRFLPEKLSRLRRLDGSLAVRARGQGTEFDALREYVDGDDVRSIDWRATARRSEVVVRTWRPERDRRLVLVVDTGRTSAARVGDIPRLDAAMDACLLLAAVAAKAGDRVELFAADVSVRTSVRGKGHASVVASIGEALAPVEPRLVESDFDLVVSEVLLRARKRCLVVLFTAIEPAPLAEGLLPVLSRLTDRHTVVLASVGDPAAAAMAAQRGTTEAVYEAAAAARGDAERRRIVGAMRNRGVEVVDAPADIFASTVTDTYLAMKAAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIJ0</accession>
    <name>A0A010YIJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1116"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="107"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="36467" checksum="96A98540D129464D" modified="2014-06-11" version="1">MSSRADSKPGAVTDSPAPASRKGGGAPGAGAPAKKIRRTTRGRAPWWVALIWLGPALALIFGVVIYPAIELVRASTGEYSITGLRRGPAGIDNYSHVLSHPALGTVLLNTAIWVAAVVLITIVLSLGLAQFLSKEFFGRRLVRWAVLVPWAASLVITARLFTLIFDYYHGILNVFLLKLHVISEPIDWLGDDTWTMPSMILVGVLVSIPFTAYVLLAGLNSIPDDVHEAARIDGASAWQAYRQVTFPLLRPALLVSAVLNMIYVFNSFPIVWTLNDRNPGYTHDTTITFMYKLAFKSADRDVGASAAAGVFNVLLILVAVVLYLRLVKWREEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJD3</accession>
    <name>A0A010YJD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083318_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="21221" checksum="6BC7521E21B6A04E" modified="2014-06-11" version="1">MTVPVVERRDLGVFLGRVVRLDAGALVRIRPSGPDHLTLWASLPFDVLVARTVPGMWLDDATVRATELLESESPQRRDSEWRGSLPPERGWQVLDTVPSAVVRDLITAGQKAFRAAGTQAAGESLLDHETLRVRGDAPGAPEVAVTFRLLLALARMAFLGDRPVEVATCGPWVRLSADHGTAYHRTAAFGVTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJG9</accession>
    <name>A0A010YJG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1427"/>
    <dbReference type="HOGENOM" id="CLU_012505_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="158"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="793" mass="86435" checksum="31D0D02F798C81BE" modified="2014-06-11" version="1">MQPGQYGRVPQPTQYPQYPAQRYPQSAPPAPAAPQRPGTQFPQQRPPANPPTFGDGGGPVNPPPGGGGGGGGGGGGDGSGGEARKVPPRPRFLFVAFLLLVLVAVLMVQAYVQAQVATPKNVHNAGASDEVPDKVLSGGPIIDTTHKDKPYSYSLPDKKIALTFDDGPDPKWTPKVLDLLAKYNVHATFFLVGSAVTEHPDLVERMVREGHEVGIHSFTHPEMSEMGAWERKLQYSQTQMAIVGAAGVTTSLLRFPYSSQPDAIDNVYWPIVKEAGELGYLNVVNDTDSEDWKKEGVEKIITNSYPKKGQGAVSLFHDAGGNRKMTLEAIAEMLPRFKNEGYQFVTVGEGLKMSPDWNNADGGANFQAMQPASSGEIWRGRAMIWVVQASGWFVTGLVGLLTVVGVLTLARLVLMLVLATVHARKRRAKNFRWGPEFLEPVSVVVPAYNEKEGIAAAVRSLATSNYPMVEVIVVDDGSSDNTAEIAESLGFANVRVVRVPNGGKPAALNIGTAWARADVIVMVDGDTIFEPDSVYELVQPFADPRVGGVAGNVKVGNRQSIVARWQHIEYVIGFNLDRRMYDMLQCMPTIPGAIGAFRREALTDVGGVSHETLAEDTDLTIAMGRAGWKVVYEEKARAWTEAPSTIQQLWKQRYRWSYGTMQAMWKHRKAVFESGPSGRFGRFGLVFLGIFQVGLPLFAPLIDVFALYGLVAYDAALSAGAWVGMLALQFFLAVFAFKLDKEKLGPLWSLPAQQFVYRQLMYAVMIQSVVTALTGARLRWHKLHRTGLQAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJS6</accession>
    <name>A0A010YJS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849405.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_7_2_11"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458856" evidence="1">
        <location>
            <begin position="35"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="33292" checksum="589B05E09EA19DB9" modified="2014-06-11" version="1">MSSRLRSAALSIGAAAALTLAVAGCGGEGTVAQASASRSAGADYPVTVESCKRSETFTAAPQRVVLGWATSIRTLAALGVADRVTGYVSGSNVKVPDGFTATEVSPDFQPAKEAVLAARPDLFLANDENQISGQQGTATPDDLAAQNGHAYVLGGYCLAAPAPGTVDAVYADVEKLGKIFGVGPKAVDVVADLKKRVAQAQKPRGNAAPAKVAMIQVYDGKVYALSGSYYNAILEGAGLTNVFGDLKENFAEISAEKVLTVKPDALFIAHDDPAGGDEALAAARKEFAASPAVTAGKIFGISNLEISGGGVNIVTLIEQTAKQAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJY6</accession>
    <name>A0A010YJY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1615"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="170"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="43970" checksum="C75AC14C4F63D414" modified="2014-06-11" version="1">MVKRPEFFRSIRFRLTVIYSTLLFALAGGALAITYVAVSETTSPRPISQQTAKVYNTQWKFVGTTTVAEVSEIEAAVNYNTLQHLRNYSAIALGGLFVASLGIGWVLSGRVLRPVGAIARTARDIQATDLSRRIHLRGPHDELRELADTIDSMLDRLDDAFSAQRQLIDDASHELRSPLAIIRTHLDASLNTEDASPEERRRSVAVVDRATTRMSRLVEDLLATARRDASAMTDTDVDLSTVAREAGEESFLPERPLGLRYATVPGLHCIGDTDALRRAAGNLLSNAVRLAPEGSTVTIATGRVGSWLWLAVADEGPGIAAEDLPKVFDRFWRGANGKASGRERRTGLGLAIVRQIVESHGGQVTAYSTLGVGSTFVFWLPAADRSDEEPPPTADPLSDTVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL12</accession>
    <name>A0A010YL12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1985"/>
    <dbReference type="HOGENOM" id="CLU_047540_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="41566" checksum="B22D3B7042F53C76" modified="2014-06-11" version="1">MSDGGDDTSAAPVTHGAPTGPLPGPRPPVSGWPQPSQYGGSPVPPPTPSQTTGPVPSRPTEAFARPTSTFAPPTNGYAPAGGYASAAPASAPPASAPPYGTGYPGTGPQGPGHSGPGYGLPGGGYPGSGGPTSAVPFGSGPPGGGLPPVRGDRRPRPFGLIGLVLAIVLLIVVIVQGIFLVNVSGDLDDAQAAQAKAETASAKDREDMSNLTKRVQSLEERTEGTLNSTAVAKKVLPSVFSVRAGQATGTAFAFATAPGGGTLLITNYHVVDSLVSSGGKNATITRNSETYPVTIDRTDKDRDLAVLRTKAKFTPLKPSEEEVEPGDPVIVVGAPLGLTDTVTTGVVSAIRDDVEGLATRVIQFDAAINPGNSGGPVINAEGEVVGIAQAKIIAEGADGLGLAIPIGEACKGLISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL77</accession>
    <name>A0A010YL77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850137.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2050"/>
    <dbReference type="HOGENOM" id="CLU_012762_1_0_11"/>
    <dbReference type="OrthoDB" id="1815809at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="403"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="460" mass="47753" checksum="5F62BADFC985FFED" modified="2014-06-11" version="1">MSSTFSGISTALSSLRAQRQGLDVSGQNIANVNTEGYSRQRTEMSSVEGVSNVPTIWAKQDPVGTGVNVGDVTRIRDELLEARVRTEHGNNAYHSGQSQIYDSVQAVFKEPSDTGLQERLSSFWSDWQDLSNSPGDGAVRTKVMQQGGAVATGLNQAHSQLSTIYSSAHAGAAAQVKDINTAAAEIASLNKGIMQAKVGGLPANELADRRDGLVLKLADLAGATATVRDTGAVDVSLFGSTLVSGTAARALALNGSETLSEQGSNPPSLTFTDNGQPAIVTSGELGSSMDSLNTVLPKYAKSLDDVAAKLAATVNGIHQSGFDRNGDAGEPFYTGTDAESITMAISDPDKVAASGSANGRLDGSIADALGDVATSGTGPDVTYRQLVADLGVTAKSATLKAETQSTITADLDSNHQSTSGVSLDEEMSNLLQYQRAYEAAAKLMSTIDQTLNTLINNTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLM7</accession>
    <name>A0A010YLM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725892.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2193"/>
    <dbReference type="HOGENOM" id="CLU_034180_14_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="41122" checksum="32D6D78DD5EC43FB" modified="2014-06-11" version="1">MPGDRRTTVLRDREFRGLWLAQTLSRLGDQLARVALTVLVFQTTGSAPAAAAAYAVTMLPWLIGGPLLGWIGDRYPRRAVLITCDLAGAALIALMALPGLPLPALYLLLFVATLLGVPFSAARSALVRDVFPDDDRYASATAIGAVTGQFAQVAGFAAGGLLAAATTPRQALLFDALTFLVSAVLVRRTVADRPAAAAGPSRPGERHALAGVRLVFGDRRLRRLTGYAWLATFHTVPAGVVAPYAAGFGGGARTIGFLLACTASGTALAMVGLSRWVSADRRLLLLEPLAVLAGVPLALCVLAPGPVLTGFLWAVSGAGAAYQLAANVAFVRTVPDDSRAQAFALVAAGLVAGQGAGVLLAGALTVVVPSHLVVAGAGLLATLGALALWSAKQPAGVTITSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMA4</accession>
    <name>A0A010YMA4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">CryarDRAFT_2456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850635.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2419"/>
    <dbReference type="HOGENOM" id="CLU_061901_1_2_11"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="20156" checksum="D1ADD48CCEE3DC5F" modified="2014-06-11" version="1">MSVRPVRLFGDPVLRTPADPVVDFDRQLRSLVKDLTETMLQERGAGLAAPQLGVALRVFTFDVGDVVGHLVNPVLEFPDEQEQDGPEGCLSIPGLYFDTKRRLNVVAKGHDMHGEPVQIVGTEMMARCLQHETDHLDGVLFVDRLDAATKKEAMKAIRQAEWADQPAPTVKVSPHPLFGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMR1</accession>
    <name>A0A010YMR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2589"/>
    <dbReference type="HOGENOM" id="CLU_019375_7_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="483" mass="49903" checksum="DC79BEFCF4575F97" modified="2014-06-11" version="1">MSTTADAPPGDTPPPGDTPPPGSTPPPRDENPPQPPAPRKRDRTHFLYIAVIVAVVLGATVGLIWPDLGKELKPLGTGFVNLIKMMIGPVIFCTIVLGIGSIRSAAAVGKVGGLALGYFLTMSTFALAIGLVVGNIIQPGSGLDLSGNADAGKDLAADAEGTTTEFLLGIIPETMVSSLTSGVVLQALFVALLVGFAIQAMGRTGEPILRGIGYFQKLVFRVLAMIMWVAPIGAFGAIAAVVGETGWDALTALLQVMLGFYITCAIFVFGILGTILWFGARINIFSLLKYLAREFLLILSTSSSESALPRLIAKMEHFGVSRPVVGITVPTGYSFNLDGTAIYLTMASLFIADALGQPMSISEQIGLLLFMIIASKGAAGVTGAGLATLAGGLASHKPALLDGVGLIVGIDRFMSEARALTNFAGNAVATVLIGNWTGAFDRDQAARVLAGDAPFDEATMVDDDHHGGGQASEPEPALAGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPU7</accession>
    <name>A0A010YPU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863315.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3321"/>
    <dbReference type="HOGENOM" id="CLU_860054_0_0_11"/>
    <dbReference type="OrthoDB" id="1093055at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="36197" checksum="5946E7D9C7E171B0" modified="2014-06-11" version="1">MTRAFLRPDDVHDVVADQFGVDRRLNTMDRLTGGSKKGVYRLRLDDQTTVILYVWSESENYWPSAPNVPDDPFTDASGAELFAAGHAALTAAGVPTPRLLMLDRDHRYLDADIALVEDAGATTLETLIDHDPAAAAAPLSRLGDALRRLHTTRGPHYGKLASLTRSEASQERRTEDIIVDRALGHLHAAAPRDARIAAAHQRIADHLHHLRGAVEARQDYVLVHGELGPDHVLVTPAGESALIDIEGLAYFDAEWDHAWLRMRFGDTYPALRPVDLDPHRLELYRYAQILSLIEGPLRIADTDYPNRQWMIDLAQWNITQALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQB4</accession>
    <name>A0A010YQB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2681501_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015452970" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="74" mass="7948" checksum="920F40149CCA5A9A" modified="2014-06-11" version="1">MKRWIARLAVPVMIGGATLGIAAPASAGQWVSGGHYEYLSGCLNVGAARYAHGLYERYACERDSPGYLLRGYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQF0</accession>
    <name>A0A010YQF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014589_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="28637" checksum="2D9BD03EB19458D1" modified="2014-06-11" version="1">MPRFCELTPETVSLSPAAGGSAVLTYASRFGTVAGTVDPDVPTLDVLDRALRYPTTDHGEPAVVRDGVFVLPNGVTAQPGTLTLRVGATPARRAAGVTVDATRVPSGVSTRTDRPQPSVSPGDFARCGDRPGVPPLVDAHAWRPTVTVDLGSGELLRLARTVFYDFSAEKHGSDTAAVTGLVTDERSTKVSLGGRGHRTISVPVVGGTLVLPGVNLGRLPTHRGDACAKRRHEMLCVTSVAYLDMVASAAGSAVPPGRSWQQGTRWESGTAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR14</accession>
    <name>A0A010YR14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enolase superfamily enzyme related to L-alanine-DL-glutamate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852554.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3799"/>
    <dbReference type="HOGENOM" id="CLU_030273_3_1_11"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="42450" checksum="5FD9B08098314133" modified="2014-06-11" version="1">MKVTGYRSLLTTHEWGRLTGDANGVMPGPRTDVHVLILETDDGVEGVGVGAHGDIDRVFDAVEGEDPRAVTALYDRMLNRVFKTGHAGATFGAIGAIDMALWDLKAKYAEEPLWRTLGALNRFVPGYASGLDIALGDEELVQLYQRYADRGFSAAKLKGGHDVEHDLRRLLAVRDVLGRNSDRPALMLDANESWNRTQAVRYLTELERAIDLAWIEEPLRRWDAAGHASVRQHVRTAVATGENLTGLEQYRPLLDADAVDVVQVGNVWGITHFLRVAAVAHSRDLPVSPVSYHGNPLAHAAAAIPNHLSFEIQHLHSPVGLEIDQEFSDGGIVLGDEPGLGIRVDESVIRTATPATPLAGIAGPHVRPDRAGLRLVPDPARATPAPAALGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR54</accession>
    <name>A0A010YR54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852612.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3843"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="24133" checksum="DC1E834228987235" modified="2014-06-11" version="1">MGTGRDAIAEAAFGLFATRGYEETSVEDIAAAAGVSRSTFFRAYGSKEAVIFPDHDELLRRVEERLTSTTADAALKAVTEAVKLVLFHYVAEGERARERYRLTSAVEALRDRELISGARYQRLFRRFLGDWGDGSEAAELRAELTSAAVVAAHNHVLRRWLRGESVDPHAEVETALADVRATFDPASRREPVAVLVVPTGLAMSDAESAIRRALGGASNVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRT1</accession>
    <name>A0A010YRT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein, gamma-carboxymuconolactone decarboxylase subunit like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852993.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4102"/>
    <dbReference type="HOGENOM" id="CLU_070025_4_0_11"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="13158" checksum="D063452BAAB94C0D" modified="2014-06-11" version="1">MTDDRRRGLETMAQVYGFELQDGDGDFWRYTVDHLFADIWNRPGLSIRDRRLLIIGALAATGTLDVLGIQLPAAYRNGELTEEQLREIVIFLSHYVGWPTGAKLNTLVEQVITGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVS0</accession>
    <name>A0A010YVS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569572.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1401088_0_0_11"/>
    <dbReference type="OrthoDB" id="1652022at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="19517" checksum="51655BEB89286097" modified="2014-06-11" version="1">MESRNTVIRSMHDVGLASWFGGSLMGAIGVNGAANEVGDEKDRVRVAAAGWARWSPIAAASIGTHLVGGLGLVVANRGRVAGQAGVTANTVAKTAITVAAVAATVYSGVLGARVATAGKVPAEGSVVPGEQTPEDVAATQRQLRVVQWVIPALTGVLVVLGAQQGEQQKPNQRLIGAAKRSARTARRLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXC0</accession>
    <name>A0A010YXC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848599.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.848"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_0_11"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="14914" checksum="8939E86895844518" modified="2014-06-11" version="1">MNITIANTFLPADNPEKSLEFYRDALGFEVRLDVGYGDMRWITVGPPNQPQTSIVLHPPAADPGITDDERRTIAELMAKGSYASIVLSSDDLAATFDQVVKSGAEVIQEPMDQPYGVRDCAFRDPAGNMVRINQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY98</accession>
    <name>A0A010YY98_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">CryarDRAFT_1254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055097_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="26184" checksum="B00484BB19EC6802" modified="2014-06-11" version="1">MTRARPGLRASARAVVEQVGDRTVFRELASQPPIVLRRTDRGLTMVTGAAGPLGGDRTDLTVVVGDGASLTVGSAGASLALPGAHGGTSSASVSLHVGSGASLHWEPQPLVVARGADHVVSLDVTLAESARLTLVETLVLGRHQETPGRLRTRWRVRRGGRPLLAQDLDVGTGAPGGWNGPAVLGDAVVQATALAVVPSVSPIDADPVTTVGGVRCDVLTLADPSAVLVVAIGPDTVRVGRALDAALWGRLTKTGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYV1</accession>
    <name>A0A010YYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849250.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1445"/>
    <dbReference type="HOGENOM" id="CLU_018914_0_0_11"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="561" mass="60756" checksum="0FBE44ECA28E0E0B" modified="2014-06-11" version="1">MTLDPSVTASSLADELLELVCQSDPLGASLLGLPGYDDGLADMTLAAEERYGALFGDLADRAAALEVTSETDRQTRDFVAHVAGTTREVSELRTVEWTITDFFVAPAATLIDLLPRVPLVTPEKAAGFLARLGQFPSYFAAVGERHREGVAAGRVPIASLVRAAIDHLDRVLADEDLSGLRVAGGPGVADQEAFATERDRLLAEAVVPALTTYRDLLRDEMLPAGRPDDRVGLTYLPGGERIYATLARKHTSTNRTPEELHQVGLQIISALEAEYAETGSRVFGTSDQTEIFRRLRTDPALRYSDSEEMLAQARSAVDRAWAAAPGWFGRLPSTECVVEPVPAAAAPGAPPAYYLPGAIDGSRKGTYFLNTSAPTERNRHMAEVVAFHEAVPGHHFQISLAQELTALPLARRLLNDTAYAEGWGLYCERLADEMGLYSDDVARLGVLATDSWRAGRLVVDTGIHAMGWSRQQALDWMLTHTPVSEKECATEIDRYIAYPGQALSYMVGRLEIQSLRARATKELGDSFELSAFHDVVLAGGSLPLAVLADVVDRWIAASKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZQ1</accession>
    <name>A0A010YZQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849688.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053163_2_0_11"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458956" evidence="1">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="32013" checksum="6C58EEEBB474F48B" modified="2014-06-11" version="1">MRILVTGARGKVGAAAVAALVAAGHDVTASDLTPPSFNRPAPDAAPVDRVPYVTADLGAAGDAYALVGGISAGEGPKGGRYDAVVHAAAIPAPGSHAPATVFTNNIGALFNVVEACVRWGVPRLVNISSETATGFHFAERPAYPRYLPLDEEHPCTPHDPYGLSKFFGEQLCDAAVQRSDVKILSLRPTWVQNDASYPLNLGPMLEDPDAQSLTGWSYVDADDLGDAIVLAAESDVPGHEVLYIAAADTIGGRDLHATWRAVYPDAPTELRPVTRPDASGIDCAKAERLLGWRPKRSWRDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZX9</accession>
    <name>A0A010YZX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2681499_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="74" mass="7476" checksum="6AF3CFB95D494C9F" modified="2014-06-11" version="1">MGVAVGAGGPGAGAGVDGSGTEGAPRMVRVRRHYRPAAVENADPADEQLAAYNAYLASLNPPSNRAPKTEETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1T0</accession>
    <name>A0A010Z1T0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ORF">CryarDRAFT_2489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570070.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2452"/>
    <dbReference type="HOGENOM" id="CLU_097103_1_1_11"/>
    <dbReference type="OrthoDB" id="1640037at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="19498" checksum="C8AA25F83095CEF4" modified="2014-06-11" version="1">MSNPVTKAARHARISELVRTTPIPSQTVLARLLADEGMAVTQATLSRDLEELGAVKLRGADGSPASYVLPEEGAAPMRPSVSPPDQLIRRLQELLTGAEASGNLVVLRTPPGAAQFLASGLDRSGLPDIIGTIAGDDTILVITRETDGGEAFAGKVLDWAHQRGSATVEVNTSGHHHAATLLKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1U2</accession>
    <name>A0A010Z1U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850697.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2468"/>
    <dbReference type="HOGENOM" id="CLU_072020_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021522">
        <property type="entry name" value="MctB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11382">
        <property type="entry name" value="MctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458974" evidence="2">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="31866" checksum="8B3E6640F1F657B4" modified="2014-06-11" version="1">MINFRYHVVSLTAVFLALAVGLVLGTAALNGTVQNQLNEQVSGLRNSNGQLRDQVEELQTRAASQDEFVRQIAPGLLAGTLTGRSVLVVSGPTADNDDRDQVVKMLALAGAKPTGQVRLRKDFTDPNKDDALQDLAARVTPASVTTLPNNGVGVETSSALLANVLLADPAKITTANRTTILQAYESLGVLDLDGEVTATPATAVVMLTGAPETGTGSADRNKAFTEIVKQFDTVAGQMVLAGTTAAGAGNPVAAVRDDGTLAKAISTVDGVSLAEGQVATAMALAEQFTGRVGHYGTGSGASARIPTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1Y8</accession>
    <name>A0A010Z1Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056545_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="26961" checksum="37D59706F927710B" modified="2014-06-11" version="1">MDHAISGSVATRPSGRTSGKPGAATRPGPGRPPIARTGQSRPAQRLSLVPGTTRPAPCATPLTEPRPTSAAARNRPWAFAAERLAVAPQTHASIEVAVLAFLRGRTPSAAAPRRRRGFVGTRVAEFVLAGTVGVLAVLVALVAVATLLPGAAGAGAVGLVFLAATGGLAGYASWRWVRWMRDRAERLHWSVIAAAGAATTAAELYAAAAIVASHSGFLERIAAFGGLGFVAALTIAITGAATLTSYHRSVTDAQLIHSARRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2F0</accession>
    <name>A0A010Z2F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="93"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="26011" checksum="AAA4390BD72D7739" modified="2014-06-11" version="1">MRVSRLTVVPVKGLRAEHPASVVVTPTGIVGDRQFFLVDADGKLFSASRTGAFLGARASWSPGFLDVSGVRAPIELGPAVEADFYGLKHVAAHEVLGPWSAYFTERAGQPVRLVHADEPNGGCDVHALTLLGEASVGELASRAGVAPVDSRRFRMSVEFAGGAPHAEDGWAGAEFRAGSVVLRVGGPVPRCAATTRDPDGGATDLKTLHLIKGYRGVTVGELGRGIHFGVYADVVEPGEIRVGDELAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2I2</accession>
    <name>A0A010Z2I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851035.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2713"/>
    <dbReference type="HOGENOM" id="CLU_035117_1_1_11"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="160"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="29256" checksum="523270D87F69ACBD" modified="2014-06-11" version="1">MTIAFVGLGNMGAPMAARLLGADHAVHGFDLDPAALRALAELGGTAADTLADAVRDASVVVLMLPGSSAVGATLHDEGFVAGPGTVVVDMSSSEPLRTRELAAELAARGVTLVDAPVSGGVARARTGTLTIMAGGEPADLDRVAPVLAPLGTVTRTGAVGSGHAVKALNNLLSATHLLVTSEAILAGERFGLDPETMVSIFNGSSGRSGSTENKWPNFILPGTYDSGFGLRLMLKDMRIATGLADQVGAPDPLGHAAVELWARAAEALEPNADHTEIVNWLRKDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2S9</accession>
    <name>A0A010Z2S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851149.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2809"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21544" checksum="2F3D5D9BCACB04BF" modified="2014-06-11" version="1">MITVLLVDDHPVVRDGLRGMLDAEPDLEVVGEAGSGPEAVVLARTLRPDVVLMDLRMPGGDGATATGRIRAEVRTAHVVVLTTYDTDADILRAVDAGAAGYLLKDASRAELTAAVRAASRGETVLAPSVAGRLVQQVRRPAGPQLSARELEVLTLVGQGLTNAEIGARLHISEATVKTHLLRTFTKLDVSDRTAAVTTAMARGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2Y2</accession>
    <name>A0A010Z2Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851193.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2840"/>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_11"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="481" mass="50799" checksum="880041D32B632834" modified="2014-06-11" version="1">MSLLLRDVRLVPVTGAADAGVTDVRLEDGTVTALGEPADRVIDAGGRWLMPGLWDQHVHFRQWAQARLRLDLSGTTGPAEAVARVRAHLESRPAVVVGAGFRPATWSEQPRTAHLDALSSTVPIVLISGDVHCGWLNSAAQRWLGVPARAGVIDENDWFTLVPHLEDRLAADLDQAYRLAQSDAAARGVVGIGDMEFEPGFRAWPARFAAGIDGLRVRTATYADGLEDVIAAGLRTGSVLDASGLLTMGPLKIISDGSLNSRTARCCEPYGDGRHGTQNYPLDELVRLLGRASGAGLEIALHAIGDAALTTAVDAFEATGARGGIEHVQLARFADFGRMARLGLRASIQPAHLLDDRDVAAEIWPDRTERCYAFSSMLAAGVPLALGSDAPVSPLDPWLAMAAAVHRSADERDPWNPAESLTAAQALAASVDGRPTVAPGSPADLALLDANPLEPGADAAGLRDMRVAATFVAGRVTHLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3B0</accession>
    <name>A0A010Z3B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851363.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010649_0_0_11"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="29163" checksum="F2A1F3B1F8650479" modified="2014-06-11" version="1">MTRVRVLTLNVQHDAGDPGRTARINAELRRLAPDIVVFPEVRYPDDTRDQLAELVDGVGLRTTHQAEILEHLPPDADVYGGSAIATRWPHRVLEVVDGRTPEGVYWYTLAASVELPGAGPVLLLTPTTFWKPDAEAWRERQMLELAALDARHRTRLPTIVAGDFNAVPESASIRFLSGLQSLEGRSAYYHDVWAVAGDGPGHTWTVDNPLGAAEIERLVGQPGVRYRIDYVFVGSGPGARVVGAAVVGEENPLSDHHGVLTDLVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3G7</accession>
    <name>A0A010Z3G7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851465.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3032"/>
    <dbReference type="HOGENOM" id="CLU_006354_2_6_11"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458241" description="Peptidoglycan glycosyltransferase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="73"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="359"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="692" mass="73236" checksum="8740AD4DA7CBCE58" modified="2014-06-11" version="1">MTKTRRSRHLIASLVLCGLLAGVVLAAAAFPAAGFTGLTAKSASDSFSDLPADLELPPAPQASTLYASDGRTEIAEFYDENRRNVSLDQIAPVMRQAMVAAEDNRFYEHRGVDLKGIVRAFVNNQKQGSSTQGASTLTQQYVRASLRYGAKTPAEERLATEDTAGRKLREIRYAIALEHELDKDQILANYLNITYFGNGGYGIYAASQAYFSKPPSELTLAEAAMIAGLAQNPTQYNPVENDHRFAIDRRDYVLNQMVKLKYVTRAQADAVSVSDLGLQPKSSAQSCENGDTAYGFFCGWFLDWWKSNPAFGPTTAERVDNLRKGGYSIVSSLDVGMQKAAQQQVDAALDTADKRFATGVVLVEPGTGRVKAMAVNRAFGIGAGQTVVPLLSGSSMSPGYQAGSTFKMFTAIAALQKGIPLGHELFAPDRYVSKYPGECAVGGDRYCPKNASPKMTGEQTMSSAFGESANTYFIQLEEAVTVKSAIAAAESAGVVLRGSQDVQLARAAQRSPTAWGSFTLGTAQVSPLDMANAYATVAARGTYCAPLPLTSISDQGGKQVASLADPSCRQAFSPSVADAAADMARCPVGQQSMVGLACAHPGGNPTAASVGAAIDRPVAGKTGTTDDNNAAWFIGFTPNLVAASFLANPDKYDDEVPDTKTPINVTRETLVAVLPGLPAESFTAPTNALAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3J2</accession>
    <name>A0A010Z3J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570248.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_11"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="436" mass="48331" checksum="038E76CFD75DDDD4" modified="2014-06-11" version="1">MNTRTADLPPGPRLPEWVQSAAFLSLRHRIVPFLRRRYGETVRLRLVGGRTAVQLSNPEHIRQLLAGSPTTFHANRGNAVLRSLLGEHSLFLADEDEHTRLRRLLWPAFNGAALRGYGELITGLAAEDAERWPSGVPFSAHARMQTLTLEVMLRVVYGIADGPRLDELRVRFPELLDIGPLDLPGLQKPELQRFWVWRRKAELQRRVDALIRAETAERRKAPDLAERTDVLSQLLRFSAGSGADGLSDAELHDNLITMLVGGHETTATALAWALYELSHDPDQLAAAQRAADENDQKYLEAVVKESLRLHPVIHEVGRTLTEPVDLGGYRLPAGTLVMGSIGLVHADPTLFEQPAAFRPARFLDGNPPATIWLPFGGGLRRCIGAAFSLVEGVIVLREALVRWQLRPAGDRTEPARVRNLMLVPARGARISAVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3V3</accession>
    <name>A0A010Z3V3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570313.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3167"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="32120" checksum="84E9E2898153896E" modified="2014-06-11" version="1">MEATIGEFLRTRRERIQPGAVGLPAGVTRRRVPGLRREEVALLAGVSPDYYTRLEQGRTAHVSDRILHAVAQALGLSDVETEHLRNLARPARATTLPRTAAAMPDEPLVRLLRAITDVPALLMNDRLDILAANPAAEAVFDVDGMPRPRNTARQLFLHPEARSLYVNWDAVAAETVAQLRLATGRRPHDPRLAALIGELSIRSDPFRHLWATGDVGEKRLGTAQLLHPVAGALEFDYQVLTVPARPDRSLITYLPRPATPTAEALAVLLSWVAEQPSQPGRGSTTAPGRSSTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z441</accession>
    <name>A0A010Z441_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3253"/>
    <dbReference type="HOGENOM" id="CLU_087944_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="192" mass="21218" checksum="707B05AEA4137C48" modified="2014-06-11" version="1">MCVANLDRKSTIIDVNVELVRQFGRASWEICGQQFCDLLHPSFREKIAEQFGRLATGQRVRFDETMIVLRPDDTAFAGELTGIAVTGSAGMIEKIVVLFSPDAGNDDQQLARRQQLLTSMETRVLEGVAAGVSTVQLASALFLSRGGVEYHVAMLLRKLKVNNRPALVSKAYSMGIFRLGSWPPRVLTDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z493</accession>
    <name>A0A010Z493_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863304.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3319"/>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_11"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="112" mass="12513" checksum="6CB1FFF0D4683602" modified="2014-06-11" version="1">MLNRQDPLDRLFQALADGTRRAIVERLVEGPAAVSDLARPFGMSLSAVLQHLQVLIEAGLVVSEKSGRVRTCRIEPGALRTTEDWIARQRTGWERNFDRLGDILNKSGDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z508</accession>
    <name>A0A010Z508_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852235.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3577"/>
    <dbReference type="HOGENOM" id="CLU_038034_9_1_11"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="30787" checksum="F1DD20E718128795" modified="2014-06-11" version="1">MRVVSLLPSATEIVYALGLGESLHGVTFECDEPSDARREKTVVVGGRDTRGMTPGDIDAYVREAGPAVYTLHAGALARLQPDLILTQDLCRVCALPSGQVERALDHLGCRADVLSLDPHSLDDVLRTISAVGLRAGVPQRAEAVLARLRARLDAVRDAVAARPRPRVVVVEWIDPPFPAGHWIPDLVTAAGGEPLAARPGARSAATTWDELTGARPDVVIVSPCGAHLDAATDQARGIAHRFPDAEIWAIDADGLVVRPGPRLIDGVEAIAAILHPDAVPPRPEAVTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6C6</accession>
    <name>A0A010Z6C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_4049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570691.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4022"/>
    <dbReference type="HOGENOM" id="CLU_000604_70_6_11"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457833" evidence="8">
        <location>
            <begin position="38"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="290"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="327"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="567" mass="59757" checksum="CC6DFC1A06C3B3A3" modified="2014-06-11" version="1">MPRTFRSPQGIAVVVGLLVVVLATVLGPTLSGDAATARDIANRQAPASLAHLFGTDPLGRDLLARTVVATRLSVLLTLGAVGISVGGGVVLGVIAAVLPRFLRRLVTAFIDILLSFPWLLLALFFSVIWGATSTGAMLAIGFAGIPVFARLVSTLASSVANTDYVHAARLLGSSPLRTAVRHVLPNILPPMIVNTAAHASVTLLSFAALSFLGLGVQAPEYDWGRLLNEGSKQIYVEPMAAIGPGIAIVLTGVLFSLLGELLSESGPRRVRAARPAGVAEATGEDENAVVDVEQLRVSFRGEDGALIERVHGVDLTIAPGEVVGIVGESGSGKSVTAMAVAGLLGPEALVESERLRFRGIDMRTRPSAAERRTLGLEQAMIFQDPLSSLNPALTVGRQLTEASEVHAGHKRGAATKRALEAMALVRIPEPAKRIKQLPHEFSGGMRQRAMIAMGLMGSPRLIIADEPTTALDVTVQRQVLRALADARERTGAAILLISHDIALVSGFCDRIVVMRDGAVVEQLAVADLDRAEHPYTRGLIDCVPDMTTDRARPLPVIGVAAEEEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6R2</accession>
    <name>A0A010Z6R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_11"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23540" checksum="45E54C601A0F371A" modified="2014-06-11" version="1">MTKPTLSEQIRDALLHRIVTGELAGDERLVETRIAAEFGTSQAPVREALRELEGLALIQSRPRHGRTVVPFAEQTIREAYVVRAALEEAATRLAMLRGSFSTAVLAAAVADMSRHAAADDRDGVCAASVAFHRHVVEAGDNLLLRRSWESLQIEARTMIALVTLEPSLTAVAAEHQDLLDVMRAGDVEDACRHAREHQLAYAELPVVGEEVVPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKA0</accession>
    <name>A0A010ZKA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432371_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="19705" checksum="CB284B94CA5D4943" modified="2014-06-11" version="1">MLTDVARRVADPAEKLLTQSFRLAGWVVGRTAGPVFRLVGHAGRPAVETLAKISPSAAETLWSFLPGRRPAAQPVTPTPATPPRPAHVATVPSPAGAPTPAAAHAEAAALLSEVTPDAAKAATASDSLPVPNWNGLTIAAIRQRTRSLSDQDVLTLLAYERAHAARPAVILNLENRLAKLHQANGATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKI7</accession>
    <name>A0A010ZKI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2600169_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="79" mass="9195" checksum="6D3A8F9466EF87E2" modified="2014-06-11" version="1">MDSQRFRLVHDDEEGGWTAYDGDAVMFTVREHYGADETIRLFVDRVEEWFEHGDDVVVLLDVTEYGYDALIVPWSVVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL95</accession>
    <name>A0A010ZL95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506909_0_0_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="408"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="537" mass="57943" checksum="A8DB7FDF9E14D3A7" modified="2014-06-11" version="1">MNRIVEASATLPADRFAARVEAHALIEQVQISPCPEVVDRFADQAVAAGWSEVEVLLRHAQVLHSSLQGHPADEVRANCDAMRRAAEEFGDEILIALALASRALFLDDGGGATGEDLGGGLARAVAILEQIADSEPDELGLRALELPNAFVECGNVYHQYGLWELEDEMYQRACDALTRPLPASARHVGDHSRRVLVVNRLEGVTALVSALIEVGRRERARAVARDATRPSPAERAELPPAWAIEVRALEYFLDAVVDSTSGADEGTELWDALAESTWHGYRACVLLADALRAADAGEAIRSGELATRAADLLDEHRSPITTLAWYLAARTASDDGAAAGYARRLASLRWQDRLGRLGAARARLMAERVLRESEQLSRQALADGLTGLANRHAETRFVARLRGRGGQNRLAVVLVDVDHFKAVNDTFGHAVGDKVLQVIGTVLQAAVRTSSDLAVRRGGDEFMLLVDLSGRPEFSFRVDDIVRAVADHEWDAVAPGLRVSVSAGHASGAANRVDELTETADEQLYRAKAAGRGRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM47</accession>
    <name>A0A010ZM47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d oxidase cyd, subunit II</fullName>
            <ecNumber evidence="8">1.10.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.10" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848505.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.765"/>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_11"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="36051" checksum="7DADFFFE8E98EEF6" modified="2014-06-11" version="1">MELTTVWFLLIAVLWTGYFFLEGFDFGVGMLLPILGRDDTERRVLINTIGPVWDGNEVWLLVAGGATFAAFPEWYATLFSGFYLPLLIILVALIVRGVAFEYRGKRASARWKRAWDVGIVAGSFVPALLWGVAFANIVRGVPIDARAEYTGTFFTLLNPYALLGGLATLTLFGLHGTVFVALKTHGEIRERARSLAVRVAAATIVIGAAFLLWTQVTVGKPVTWATVVGAAVALVATVVAIRAGREGWAFLASGAAIVLAVVTLFTALFPNVMPSTTADTYSLTTTNASSTPYTLEIMTWVAAIFTPLVVLYQSWSYWVFRKRIGTADIPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM84</accession>
    <name>A0A010ZM84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.782"/>
    <dbReference type="HOGENOM" id="CLU_786990_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="30440" checksum="2BD2842144715273" modified="2014-06-11" version="1">MSWSQTQEQRWSAVLRTLAELVPPGAAVVVEGSDELAARLTAAGVPVGTRGDVRISTNGRRDAADVVVDLRDPGWPVIRHVDTRLANADRWHLTESRAFFAAKAAGWDRRFGDDRPAYSAAVGDAGFRPGGVVVDVGCGTGRALPALRSAVGPAGVVLGLDLTPEMLAEARGHGVAEHAPLVLADACRLPFGSASVDGVFAAGLLMHLPDPDAGLREFARVTRSGGRLAFFHPTGRAALAARHGRELRPDEALSAGPLRESTTRSGWELTRYDDAEERFFALAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMD2</accession>
    <name>A0A010ZMD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.844"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="34728" checksum="73A3CC34A4EE08BD" modified="2014-06-11" version="1">MTSTVGLMIKTSQLTRHFTVKKKTVEAVSGLDLEVRPGELVAFLGPNGAGKSTTLRMLTTLLTPTSGTAEVAGFDVGRNPREVRERIGYIGQGNGAGHSQRGRDELISQGRAYGLDRAAARRRADELVESLGLAPVADRIVSSLSGGQRRRLDIAMGLIHTPPLLFLDEPSTGLDPQNRVNLQEHIQRLHDEHGTTMVLTTHYLDEADQLAERIVVIDHGKLIADDSPARLKSEHVGDRIVLTFSSAADATRAANRALVLDGRIDVAGPTVTIAVPEGTQLVPKLLRSLEEAGIAVAAVEVTRPTLDDVFLVLTGRSLREGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMW2</accession>
    <name>A0A010ZMW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848780.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2022870_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="12782" checksum="24E1C572FD316407" modified="2014-06-11" version="1">MSIRFSLDTADRAHFGGPEWLTLDVEQLAGAPAFELEAIEKELGHPIRLVIGALEGQASALGLRALIWLAYRQAGLRTPFGEFNIHTLKARSETVPDVQEAAAAAPLDGSPGGSATSASASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN13</accession>
    <name>A0A010ZN13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1120"/>
    <dbReference type="HOGENOM" id="CLU_106303_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="185" mass="20412" checksum="50844F5CDB00036F" modified="2014-06-11" version="1">MANVTAYVALLRGINVSRNQRIAMADLRALLTDLGLDDVTTYLQSGNALFRSDRADPDTIADEIEAAITRELGLTVRVLVRDEDDFRRVLNANPLAEVATDPSRLLVTFLSAPTAEARLDAVDPATHAPEVMAIGPREVYVWYPDGVRKAKLSPPFFEKRYPEDANAAGTARNWNTLSKLLTMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNH1</accession>
    <name>A0A010ZNH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1279"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="397" mass="42540" checksum="7C6409C988C6FFED" modified="2014-06-11" version="1">MTTRPPPPTYAHPVRLPNPARLPRWARSPLWVLITLGAYLPLALAGAPTVLKIDSVWLIGVAGAMALAFWLLRGHPVAAWYTAAALALVLPNTFEVLDDDPWQWPPLLGFTLIAAYANISARAPRRQAAWAWVIAPGLFWAYANADARAGWIVLLVAIPIVADVGRTLRRTRTALGRERELTEAEKARTAVLEERARIARDLHDVVAHHMSMVVVQAETAPYRLAGLSPEATADFAAISTTAREALNEVRGLLGVLRSEEISADLRPQPGCDDLPELIAGAVRAGADVEFTRTGEPRKPRPGVDVGAYRIVQESLANAARHAPGASARVTLAYTADALEITVVNGKGAQQAEPHSAGHGLVGMTERATVVGGELRAAPTPEGGFAVRARLPLEPSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP76</accession>
    <name>A0A010ZP76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847409.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.45"/>
    <dbReference type="HOGENOM" id="CLU_018808_8_1_11"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="571" mass="58633" checksum="D92938C5ACA18B51" modified="2014-06-11" version="1">MNLSGLVAVVAVTLATIALGLYGVRLARTTSDFLVASRAVSPTWNAAAISGEYLSAASFLGIAGLVMKNGVDMLWYPVGFAAGYLALLLFVAAPLRRSGAYTLPDFAETRLSSPRLRSLTTAFVVFIGWFYLVPQLQGAGLTLGTVTGAPYWVGAVGVAIVVTANVAGGGMRSITFVQAFQYWLKLTAIVFPVAVLLLAWQADERAELAPPTAPVFRAETNVDVRTPVRVEVTDPVTIRVDGRIDGSDRTGSATLAPGTHEIGPASVTFPADSAVPHLVGLAARDGTGWLTPSTTGGAALFGVYSLILATFLGTMGLPHVLVRFYTNPDGAAARRTTLVVLGLLGTFYLFPALYGALGRIYTPELFMTGNTDAVVLVLPAAMLDGFASSLVGGLVAAGAFAAFLSTASGLLVSVAGVLATDVLGAPEVGRSAGSVAGFRWAAVVAGAVPTVLALQLHGLDVSQVVGLAFAVAASSFCPLLVLGIWWRGLTDVGAAAGLLVGGGAAAVAVLLAVAGPTLTGWPAALVAQPAAWTVPLAFAVMVTVSVVTRRRIPANVGAMMLRLHAPESLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPJ2</accession>
    <name>A0A010ZPJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569924.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057474_0_0_11"/>
    <dbReference type="OrthoDB" id="2084577at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459198" evidence="1">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="12654" checksum="74EBBC2D3FF3D9AE" modified="2014-06-11" version="1">MRRATVLLTAFLLLWTAGAVRPDPATAAPPPLTAANGRNFAACKDGRCEVIVRTGDRLPTSTGTARVVVGRGVVRFTVTTANTSLMASGTAGSRLQLNRQVIVVLKVTRLQARVRLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPM6</accession>
    <name>A0A010ZPM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849604.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1689"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_11"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34146" checksum="66FFFB8C60C08B57" modified="2014-06-11" version="1">MTVTTLGKALNAALHRALTDDAKVLVMGEDVGALGGVFRVTDGLQKEFGADRVLDSPLAESAIVGTAIGLALNGYRPVVEIQFDGFVYPAFDQIVSQLAKMRARSRGTVTLPVVVRIPVGGGIGAVEHHSESNEAYFAHTAGLRVVSCSHPADAYRLLRAAIRSDDPVIFYEPKRRYWDRGEVDLDAEPASLDRARVLRTGTDVTLVAHGPSVGVALEAADAAECSVGVVDLRTLSPLDTTTLRRAAEATGRLVVVHEASTFLGIGAEIAAAVTEACFYSLEAPVLRVGAYHLPYPPALVEDQFLPDVDRVLDAIDASLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ01</accession>
    <name>A0A010ZQ01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569581.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025642_0_0_11"/>
    <dbReference type="OrthoDB" id="1901070at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="15331" checksum="96055C402C2C6A16" modified="2014-06-11" version="1">MNYRATWRGQTYEAFPAPPSPEIRLYSDVAVDGFELVGEGRWRRVVPLDSVSQLTYVRVVGVWRGEPVLVRSFSEDGFAWVEYTGGNAVVAGRLGCERVARGVYRARVRALELGDVREDEVVIDLEELNRSSGARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ50</accession>
    <name>A0A010ZQ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847888.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.340"/>
    <dbReference type="HOGENOM" id="CLU_024566_4_0_11"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="31125" checksum="9BD75A78BC5859B6" modified="2014-06-11" version="1">MDDRIIGTLLAAACADALGVAYEPEQRGPADGKPEMLGGGYGGYAPGEYSDDTQMAVVVARVAADGFDLRTEEALDRIATGFVEDWFGGGATDVGAQTRALLSQAAGRGGGAARLREIGAQLHARSGRTAGNGSLMRTAPVALAHLGDAEAIVDAARAVSALTHHDPVAADACALWCLAIDNAIGTGELDVRVGLPRVDPDGYWAERIAEAEARPPSAFASSSGWVVGALQGAWSAIVRGEGLRGGIEAAVNGGGDTDTVAAIAGALLGAAHGASAVPAEWRTVVHGWPGLDADGLAQLALRCARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQJ9</accession>
    <name>A0A010ZQJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA+ family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848184.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.514"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="304"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="558"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="788" mass="82249" checksum="BADE107D1B1FCDCB" modified="2014-06-11" version="1">MTSEAPSLTLTASLRSAVLDARRGVVRLHPEVLAALDLNPGDPVLLRSAERTSAGIAAAGDATAARGLLLADDLTMGNLRIRDGAPVDVSAAPIQAARTITVSGDATVVAAVSPEMLRLALLSKVVTSGDDVSLLPQDLDPAHPHRPLVESARRSLSNAVGSGWTAALLTVVAAEPETAALITPDTIVTWSGSAGGGVWGSGGATGVRPTASARATATPRFAGTFSPGVSGAAGAAAPVAAKARSRNVDRSMEQVFAEPGATLDEEPRPAEDLIGLKTQAAHLTELFDLAFHHGEVLERLGTTVQLGVLVTGPPGAGKSTLVRSVAQATGATVLRIWCPGLAAVAPDAAAEVLRQAAAKAESDTPAVLLLNDVEALAPRSDPPPIATVLVQLIARLVSESRTAVVCTTSRPEDVDAGLRRPGVLDHELRVPMPDANERRDLLALFTRNLPVADDVSLDDVAARTPGFVAADLGTLVREAGVRAAMRQRDAETPEIAKVDLDAAAQSVRPTSMAESTLEVASLSLDDVGDMKEVKEALTESVLWPLRYPDTFTRLGVDPPRGVLLYGPPGCGKTFLVRALAGTGQANVLAVKGAELLTKWVGESERSVRELFRRAREAAPTLIFLDEVDALAPVRGQSTDGGTTDRVVAALLTELDGVEGLRNVVVVGATNRPDMVDPALLRPGRLERLVFVPPPDAEARADILRAASRKVPLSTDIELADVARELDGFSSADCAALVREAALAAMRESMDTAEVTAAHLATARRRVRPSLDPVQVAHLASYAEQREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQR4</accession>
    <name>A0A010ZQR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848291.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_4_1_11"/>
    <dbReference type="OrthoDB" id="1848512at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="13375" checksum="4443ED68D2FD4253" modified="2014-06-11" version="1">MRPPNETRPTDPGDELDYRFSLANERTFLAWIRTALALVGGGLAVDQLLPELGRPTALRISIATVLLVLGAATAVHASVRWMHVERQMRSGNDLPPSSYPRILAVVVAAGAVLLVVVVLLGIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQS0</accession>
    <name>A0A010ZQS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848298.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.585"/>
    <dbReference type="HOGENOM" id="CLU_058962_0_1_11"/>
    <dbReference type="OrthoDB" id="886192at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26253" checksum="11798EA313BCE019" modified="2014-06-11" version="1">MPSSVLVSAGYSVVLATEVAEIRAAQELRYQVFATELGAAIDGPGVDVDRFDALCDHLLIRDDATGACVGTYRMLPPGRSTELYSDGEFRLDRLAALRPDLVETGRSCVHPDHRNGAVIGLMWAGIARYLHLSGHRWLAGCASVPLADGGEAAAATAAVVNARYLSPDTQRVEPRNPWHGPAGAPARLALVPPLIRGYLRLGAKVCGRPAHDPGFGTADFFVLLSLADTDPRYLRRFLGQQSPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQZ8</accession>
    <name>A0A010ZQZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848401.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.664"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="51060" checksum="8C06AABBC332D591" modified="2014-06-11" version="1">MRKWLPLIAISLGTFMLLVDVTIVNVALPDIAADLRTGLGDLQWVIDIYALALAALMLGVGSAADRFGRKRIYLIGMVLFALASLGCALADSSGALITARAIQGIGGAAMFATTIALINTAYTGKDRGIAFGVWGAINGFAAAAGPIIGGLLTEQYGWPSIFVVNIPISVLAFVVALRVIRESNDPAAKLDPVGVVTFTVAAFALTYGLIRAGEDGWTAAPALTAFAVAAVSLTVFVAAERTRAYPMLDLSLFKRPAFTGLMVAALAVNMAAFSAMAFASLWFQSVLGLGPIAAGAVFVPLSLASLVCSILAGRVLHDRVAPGLVIGGGLLLIGVGSALQALVDGDSSWTVLVPGLIVTGVGVGVVMPTLSAAATAAAPRERGGMAGGTVNTFRQLGLVLGIAILGGVFAGRVENVVGNRLPDAHRVADLLTGGQARAVTGAAPAEQRAAVDEIVHAAFASGLRWSYLLCAAAAFIGGVLTIVLTRSRKPATTPEPAPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR62</accession>
    <name>A0A010ZR62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848464.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.728"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="37382" checksum="C49B70E33E938D38" modified="2014-06-11" version="1">MRTQLLGRTGIRVTPLALGTMMFGAWGNKDHDECIRIVHAALDAGINFLDAADVYAFGETEEIVGKAIKGRRDDIVLATKFCEPVGPGPVNRSGGSRRWIVRAVEDSLRRLGTDYIDLYQFHRPDPDTDIEETLSALSDLVRQGKVRAIGTSNFPGGDLVEAQWAAERRGFERFRTEQLAYSIFDRHAEYDALPTAERHGLGVLVFSPLNGGWLTGKYRPGAEAPEGSRAYTNGDHFDFKAAEVRDAKLSRIQPLEDIAKEAGVTLVELALGFVLAHRAVSAAIIGPRTMDQLESQLGAADVVLSDDILDRIDAVVEPGVNLHQAGAGDRPRALTDAGLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRQ8</accession>
    <name>A0A010ZRQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779936_0_0_11"/>
    <dbReference type="OrthoDB" id="410894at1760"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="37754" checksum="C327ED9E9957B234" modified="2014-06-11" version="1">MRAPASPGWRSNRWPADPAARWLLRLSFAAPLFLLATWADTYGYRSGVHTRLERRADAVVDGGAALGGLEHAYPPVPTFLAGVLPGGELALSAVAALFAGVLLHVLAERLVLRRVPLVVAVALLASLVAAPVAAYLASEALPSIAITALFALAIDGFTRFVIDKDTEGGFVAGLSVALAAGFDSVALVFALALAVVAPSIAGARYRSERGSATATLAVVLFPIGFVTVAWLFVQWRFTGMLPTVAFTFRGGVLEGFDAAARTVLTAVGHAPLYVLGAGLAAWRRPTSLVACLAPVIALLFAAWLGVGYSPGLAYVLLAYTAVITVRRPENRVVAVLLVAAAILQITLAWWSPPVRLPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS22</accession>
    <name>A0A010ZS22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase, DNA invertase Pin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848771.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1052"/>
    <dbReference type="HOGENOM" id="CLU_010686_18_18_11"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="458" mass="50146" checksum="69B745964E9A8084" modified="2014-06-11" version="1">MRAAVYTRISDDRRGEELGVERQRQDCYKLAEAEGLTVVALFVDNSRSAYSGKPRPGYQRLLEAIKAGLIDVVLSWDPDRLHRSPAELEHFIALMERHGVGVQTVNAGHWDLSTPSGRLVARQLGAVAKYESEHKAERVRRALEQNAAAGRTHGRPTYGWTRVYDLENGRGRDVVNPAEAAVIRSIADRLIGGDSLRQITADLNSAGTPSPRGGPWAKGMVRALAIRERNAGNRVYRGDVIGKGDWEPILTDHLFEQVKAVLSDPARRTTTGTAAKHLLSGIARCGVCGAVMRSAMNRSVAAYRCSEKSCVARNRRDVDALVTAVVLERLSRPDAADLLNPSRGADQKRAVANAAELQQRLDRAADDYADGKIDSRQLERITARLRPQIDAAEAQARIVDDSPVLAGLAGNAKAAEVWETLTLTRRRAVVAATVNIMIHRARQGARVFDRSSVEITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSU8</accession>
    <name>A0A010ZSU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851183.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2831"/>
    <dbReference type="HOGENOM" id="CLU_111585_0_0_11"/>
    <dbReference type="OrthoDB" id="1919329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="19361" checksum="A8F491D426C83764" modified="2014-06-11" version="1">MGLGKDYSGQNCTFARTLEILGERWTLLVIRDAFYGVRRFGDFLAHLDAPRAVLSDRLDTLVTAGVLARRRYQDSPPRDEYVLTDAGVELWPVLFQLTAWGTRHLDSPQSLRVFRHVGCGGQLSGFTTCEACGQVVGPADVQVEPGPDTRSLRTDRVSLALREPHRILQPLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSV5</accession>
    <name>A0A010ZSV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="25537" checksum="0AC7DBDA71AFF4FF" modified="2014-06-11" version="1">METVPPVVVHPLLPAVPRTPGPLTPAPLASGTLVRRTQRDADRDRARIMETAREVFAVYGLDVTLEDIASFGGLSVRTVRRAFPTRDELIEVLFEQALGDLATAAEKATEHPDALLGFLGFLSESAQMQERNSGLRMLLRGESTGTQAAETARTRLLPGLTRLVERARESGVVPAEMQPTDLPALQFVLSNMSEYAENVEPELWQRYLAILLDGMQLPNADCGPGALPGGRLALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT82</accession>
    <name>A0A010ZT82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2989"/>
    <dbReference type="HOGENOM" id="CLU_136716_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="97" mass="10251" checksum="E184E45C7DA18F2D" modified="2014-06-11" version="1">MVPALPARSGADEVSPSDARLESSIVDLLARRAAGATICPSEVARLVGGDDWRSMMEPVRAAARRLVTAGQVEITQGGEVVDPETATGPIRIRRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTK5</accession>
    <name>A0A010ZTK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851555.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079845_0_0_11"/>
    <dbReference type="OrthoDB" id="1875436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="29249" checksum="A2F8017BD3FC9AA5" modified="2014-06-11" version="1">MASEAVAIAALLYYFGWARANQAFQYYGIDVGTLGFSTTDYILRGVSTVVPAIVVSAVLAVCSITVHRLFAAPWLSRWTAAQRTRLSWGLWGIGGLLLFPSALWLIAPAWLDGRLGYGLPLSLAASAGVVAYGRAVAAMEDERFSYEADIVPSLLALLAVTGLVWALALYGVQSGWSAARSYAADLSGKSEVTVWSEKRLSIRGPGVVATNLDAGASADVVANSAFHYRYEGLRLIVRGPDGLLLVPWGWRRGIDAVVMLAPDDSIRIDVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUX5</accession>
    <name>A0A010ZUX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of ABC transporters with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850164.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2071"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="334"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="541" mass="57262" checksum="06A9EF1F8332C1B5" modified="2014-06-11" version="1">MSTAFVSCSDLSFSWPDGTPVFDSLSFTLGGGRTGLVAPNGSGKSTLLKLIVGELRPAAGSVTVSGTLGYLPQTLPLTGDPTVAEVLGVAPVIQALNALEAGDAGEAVLAAIGDDWDIEDRTRAELDRLGLGGLTFDQRLDTLSGGEVVSLGVAARLLARPDVLLLDEPTNNLDADARHALYRVLDEWRGCVLVVSHDRALLDRMDRIAELHRGELHVHGGNFTAYEEAVAAAQEVAEKNVRSAEQEVKREKRGAQQARERAARRASTASRNLKSAGLPKIFAGNMARGAQESAGRANDMHAARLEGAQARLDDAERALRDDATITLDLPGTRVPAGRTVFSGERLRVRSLFAGDGVDLTIRGPERIALVGPNGAGKSTLLRLLSGGSPDAGVLRHGPGRVAYLSQRLDLLDLERTVAENFAAFAPDRPESERLTLLARFLFRGSRAHLPVGALSGGERLRATLACVLYAEPAPQLLLLDEPTNNLDLVSVGQLESALEAYQGAFVVVSHDEAFLASLGITRRLGLDGGVLSEAGGATPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV96</accession>
    <name>A0A010ZV96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyanate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850328.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2207"/>
    <dbReference type="HOGENOM" id="CLU_038046_0_0_11"/>
    <dbReference type="OrthoDB" id="806182at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="43458" checksum="79BD6BF8173F2D13" modified="2014-06-11" version="1">MSEQRRLPWWAGRVAALLGIVLVAFTLRQAVAAISPILADIRVDVPISNIGVGLLGTLPPILLAVSGFITPRVARGVGLDGGIVLALLLMTLGHLVRAFAPDFATLLVGSVVALAGTGVGNVLLPPIVRRYFPDRIALLTAVYVGIVGVSTAVPAALAAPVAERIGWRFSLGVWAATSVVALVPWLVLLARERRRRRADDLTLAPPAPARITRLWRSRAVRSITVVFSTSTICTYAAFAWLPVILGDVAGSTPTEAGVLLAVTGLVSTPIALIGPLLVARLRNVGWLIAAGVASFVLGYLGLLLAPATLTLLWVLLIGAGSILFPVSLVLINDRTRTHGGTVALSGFAQGVAYALGALGPLIVGLLHDVSDGWTLPLLFLLAVALVAIVPAFTLARPTFVEDELAPPVLRECTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX20</accession>
    <name>A0A010ZX20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851179.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2829"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_11"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="117"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="577"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="672" mass="69789" checksum="68A33808AAC8AE45" modified="2014-06-11" version="1">MFRTVLVANRGEIAVRVIRTLRRLGVRSVAVHTDVDAEARHVAEADTAVALGPARAYLDIAAIVAAAQRTGAEAVHPGYGFLAENAEFAAALADAGIVFLGPPPKAIEVMGDKIAAKNAVAQFGVPVVPGIARPGLTDDELIAAAPGIGFPVLVKPSAGGGGKGMHRVDDAAGLPGALVTARREARAGFGDDTLFLERFVSRPRHIEVQVLADQHGHVVHLGERECSLQRRHQKVIEEAPSPLLDAATRATIGAAAVATARSVDYVGVGTVEFLVSDERPDEFFFMEMNTRLQVEHPVTEEVTGLDLVELQLRVGAGEQLPFTQDDVVLTGHSIEARVYAEDPGLGFLPTGGRVLDLAEPDGDGIRVDSGLRLSTTVSSDYDPMLAKIIASGPDRSTALQRLDTALAATAVLGVTTNVEFLRFLLADPDVAAGRLDTALLDRRLPEFTPAAPDDGTVVAAAASRWLAAWAAASDDPWTQPSGWRLGAPAATVTRWRVGDRTVEVRLTGTPDGGSVVVDGGAPRAVVAWSDRTTLVLGLDGERRRYRVAADGDTTWIAAAGGVTAALRLLGPRPARPDAAAEATAELASPMPGAIIAVHAADGDPVTAGAPVVVVEAMKMEHVLTAPADGTLRLAVALGDRVSVGQVLARVEAEGDAGGDAGAGVGTKASDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX30</accession>
    <name>A0A010ZX30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Myo-inositol 2-dehydrogenase</fullName>
            <shortName evidence="1">MI 2-dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iolG</name>
        <name evidence="4" type="ORF">CryarDRAFT_2887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose</text>
            <dbReference type="Rhea" id="RHEA:16949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.18" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851202.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2849"/>
    <dbReference type="HOGENOM" id="CLU_023194_0_1_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01671">
        <property type="entry name" value="IolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023794">
        <property type="entry name" value="MI/DCI_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="137"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="35845" checksum="459750749625BBBC" modified="2014-06-11" version="1">MSDLRVAVLGVGVMGSYHAAALAERIAHARVTVVSDADGPRAERVARAVGARVEADPLAAIDAADVDAVVIASPGFAHEAQVLACLDRRIPVLCEKPLTLTADTAYRIVEREATLATPLVQLGFMRRFDAEYAALRSLVASGELGAPLLLHCVHRNPAQSDAFTSEMMMRDSVVHEADVARFLLDEEIVAVTVKRPRASREAPPGVSDPMLVLMETESGRLVDVEISGRSRVAYEVRTELVAEHGNAMIGLDGGPLVARTGGVRGRVQTAGFIERFATAYDTELQRWVRAARRGTVDGPGTWDGYAAVAVCAAGVEAVRTGARVPVELAPRPVRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXI1</accession>
    <name>A0A010ZXI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851425.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3016"/>
    <dbReference type="HOGENOM" id="CLU_087351_0_0_11"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="17531" checksum="CB5F31778CDF9579" modified="2014-06-11" version="1">MPPSTAPVTVRPAHPDDADTIHRLSLRAIRGSAAGHYTPAELEAWIRTRSAARHRTLIEHTRTLVAECDGAPAGFVSVATEPWDRLERGEVDQLFVDPAFGGRGVARALLAAVDDVATVTHASWRAAPVFERFGYVREETETVPLDGQTLTRVRMRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXT4</accession>
    <name>A0A010ZXT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3122"/>
    <dbReference type="HOGENOM" id="CLU_709246_0_0_11"/>
    <dbReference type="OrthoDB" id="1752977at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="389" mass="42989" checksum="E48198F427A801E4" modified="2014-06-11" version="1">MRRMVDDATETAKTAAFREFEENLAYAREIVQGGQWLEKGKVGGFEVTALYRAAWMQAMTAVDRWVHRELYERAVAIAVAPKAQRPKAFLKLQIPMDLFEDVLHNGAYLSDRFTDFLLGKFGYQSFQNYRKIEEALAHVGPTKVWGPVAELLGTTTQDLQARLGSIVDRRSHIAHEADRDPGNPGQRLPMSADQVTDVIDFLLRVVTSLEDVLGPTPEAPALRRPGVNLTRELGKRVWTRHDVDSAVAELATRDAAVAEAVRRLLEHADAHGASFKGGTGPDPSAGLHYPNISKERRSLWSLYLTPAKPSIALSIGSLLWVDEKVARRFLTTARRTLELDAALSEPDEALLRRYPTVALRPLAARSAAIDGLLSAFDAVLHPGGEIDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ38</accession>
    <name>A0A010ZZ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="39389" checksum="1137C609829D8654" modified="2014-06-11" version="1">MKALVIAGTNLRRMFRDRTTIFFVGVFPLLLILVLGLAYGGASEPRVGVSVAGSGPLAEELERRLRGADGLDVRTGDSADAVVRAVERGQLEAGVLVPAGYDRDVAAGRTVTVRVIVPPGLAGQQTQASLRAVVGLESDRLRAAQALDVPLSEAVVRVDEAQRSVPGVPVRTRTEGDAAFGTSTGRFDVGASSQLVLFVFVTSMNGAAALIETRRLGVSRRMLTTATSAGTIVTGEALGRFAVAAAQGAIIMAGSALLFGVRWGDPVASVLLMLVFALFAAGAGMLLGTLARSVQQATAVGLLAGLGLAALGGAMMPLEFFSPVMRLVAHGTPHGWAVEGFGTLLRHGGTLVDVLPQLGVLAGGAAGVFTLAAWRFRAILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ58</accession>
    <name>A0A010ZZ58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852339.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2648401_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="76" mass="8169" checksum="19A95ED8D912011E" modified="2014-06-11" version="1">MSEQRYDGRVAPGDRPDRLSLRNEGGTMTLDTRPTGLRRVLRTGAGFGLVAVGGALLWPVAAAVVAGDLWRARHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZH2</accession>
    <name>A0A010ZZH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3786"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_11_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="49208" checksum="12256B110248912A" modified="2014-06-11" version="1">MDSTLLGARAATTGFTVAAVVAAGLSIGNGWWAGPAALAAFLAGQRPGRTAPIASALVAVLAAGVVALVVVPAWLTLAGRFVVVVSLALTLPWFTGRFWRQCRELVRAGWERAAQLEREQQLIAEHARLRERTRIAQDIHDVLGHDLSLIALSAGALKLAPGLEPSHRQAAGDIRARAAAAVERLGEVIGVLRDDADQPPTAPGDAGLPELIAEASAAGLPVELHVGGDPGALPAAAERAVHRVVQEALTNVAKHAAGAAATVRVLHTAAGTHVVVENGPPPPAADRRPLARTGGHGLIGLRERVRLAGGSLEHGPHGGGYAVAARIPRQPSRPAPATAPGGTLPPEHRRARRRVGRALVAAVLVPLVSGAVLSGALMVAETLSASRSVLDRDDYARLSVGQSRSEVERFLPDRQTNHRPRVAEPTGDGMTCEYYAMTADRFDDRSGDAYRLCFRGNTLESVDDLTPAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZI7</accession>
    <name>A0A010ZZI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852557.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3801"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="33234" checksum="7828BA0D0C406FDA" modified="2014-06-11" version="1">MTVVAEVAPATGRAADRPPVRRRGSLMSYGFISLYAALALAFGVLPALYAVYLAFTDVEGGFAGITNFSKVVGDFRFWPAVTHVAFYLLIWLVALVVLVTVLAIVVHAIKVRWLSRTLRFVFYLPGALAGASSVLLWLFVLDPTASPVGGLLTLFGFDSFVQVIVPGNLPVIFAIIAFWTGAGGWIVIMYGALNNISDEVMEAARMDGASPVQIAWNIQLPMLRKWISYMGIMSLAAGTQLFVEPQLLSQASNAIVPNDYSLNQLAYQYAFQQNDFNGAAAISLLLLVIALALSAVFVTRGGLFERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZL6</accession>
    <name>A0A010ZZL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852602.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3834"/>
    <dbReference type="HOGENOM" id="CLU_108923_2_1_11"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="17019" checksum="FFBCD768F041740D" modified="2014-06-11" version="1">MEYGEIAREIYVDASPEVVFDVVSSPQHLARWWPDAARFEPAPGAIGEITFGDPGAGGKAVPFTVVDAVPPRTFSFRWAHPADRPATERNSLLVTFDLRPSGAGTVLAFRETGFREQGWEAAVLEQQYREHVTGWDHFLPRLAPYAVTLQVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A076</accession>
    <name>A0A011A076_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852927.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4063"/>
    <dbReference type="HOGENOM" id="CLU_437890_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="645" mass="66460" checksum="29537E6B90F7FC0E" modified="2014-06-11" version="1">MLAKLPLDSPLWLEFDASFSTEQALDALREVLTRRQLGESWDELRSELLHQGTVYDITSAAIPHLVDLAPALSVEERAELWTEIGFWVTAGADYYEGPVADGLQESLTAALAVAEAGALELFRERAGLGDSYFALACVTLAGHPSGGAMWSFLSPGEGYVTLTCPTCEEQDEVDGFGDPLGPPGAPPAVPDLRADARDVPGWASLADEIEAAPDLFGPGWDGFARVAVAVARAGVPETAPPAAVWCLIAAMVALRGDVAWARTITRLAGHYQCVSCQDVYSIGDLIAEDEFAEPIVPDGLDPATFADAGGFRPAPGGWPVVAGPTVATRWRASTGPVDTLTVATLPTGQSIVAGVGPSGLHRWDLGTGAPLPVAAGGAVRSSAVVTAPDGRTYVVAGGDRLHRWDALTGDPLPARPAAVRALAPAVIPAPTHGRHPEDPGWLAGLRDGRTVLVTGEEDGAVRLWDPLTAEPLGELYRTDGIGAMTSVPDRSFGDQVVTLSGALTVDVWSSAAVTGRRSSMAPPATRLAALGHESLVDVTGAPGGILLADAGGLVSLWTTFGVRLGDPLPPDPGHTGVVAVAAVTTTAGPLVVATASAADATLRLWTPSTGGVTLVDLDAPPRALHATGPLLLVATDTGVLALTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0B0</accession>
    <name>A0A011A0B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853005.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4104"/>
    <dbReference type="HOGENOM" id="CLU_037162_3_3_11"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="25554" checksum="32663241A8D5FBAD" modified="2014-06-11" version="1">MNAEQWQPPPVLLAVDLLILTLRDSRLQALLVERGVDPFIGRMALPGGFLRDAGEGLGAAAERELREEAGLDAGALHLEQLGVYGEPDRDPRGRVVSVAYLAITPRLPDPIAGSDAAEARWCSVDEIARGDIPLAFDHADILADGVDRARSKIESTALATAFCGDEFTIPELQQVYEAVWGAPVDPRNFYRKVKAAAGLLAPADTSPRKPETGRPARLYRAGPATVIHPPILRSVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAH6</accession>
    <name>A0A011AAH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.34"/>
    <dbReference type="HOGENOM" id="CLU_047963_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="206"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29404" checksum="25A7637666823C7D" modified="2014-06-11" version="1">MGVLQRFEKRLENLVEGAFAKVFKGVVHPVEIASAMQREADAHKSILGGGRTLVPNRYIIDLSPSDHDRLAQYAAPLAQELAQAQAEYIGEQGWTVYGDVIVEIERGDGLDTGMFRIAAEVYTGGVEPAHNPNPYQNPPPQGYNMPPQGGGLPPVSGPPGYGNPVSGPGYGNPVSGPPGPQGGYGARQARLITSDGRQFTIVIGSTVIGRGEGAQVRLADVGISRQHARVDFDGSRVVLTDLSSTNGTTVNGNRINAAALQHGDVVQLGTTSLTFRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAI1</accession>
    <name>A0A011AAI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164339_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458470" evidence="2">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="23941" checksum="930CE481FC0C632E" modified="2014-06-11" version="1">MWRGNGTGRRVAVLSALAVPAFLLGAAIAEPPSGARDAARAERAPGHAAFDAGTSASAAVSPAGESRARDATVPAATPPLRSGGGAAAGLTVRIVVPAGPFTSDELVRFRVRWSDGSGRYAGLTESWGDGTAASSAEVVSCTGGPGAHADELTTAHRFPAGRFRVRVTVTTADCRGRTEERTAEVTIQVDAPSDEPESGQETSAPAPPTPSSEAPSPSAEASSGVPLPLPTVEPLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAK4</accession>
    <name>A0A011AAK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IMP dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.64"/>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="157"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="482" mass="51045" checksum="9C891458676B7100" modified="2014-06-11" version="1">MQFLQASGGPTTPTADLTYNDVFMVPARSDVKSRLDVDLATVDGVGTTIPLVVANMTAIAGRRMAETTARRGGLTIIPQDIPLDVVTSVIEWVKQRHVVYETPVTLTRHDTVGDALALIHKRAHEAAVVLDGNRPVGVVTPADCAGVDRFTQVEEVMSSELLTITEGTPMDKAYGTLHDSRRRLAPVVDADGALLGVLTRTGSLRSTLYTPALDANGKLRIGTAIGINGDVAGKAEALLDAGTDVLVVDTAHGHQERMIAAIRAVRSVDPHVPVVAGNVVTREGVRDLVDAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECSSEARALGRHVWADGGVRHPRDIALALAAGAANVMVGSWLAGTYESAADLQQDGDGRLYKVSFGMASSRAVRHRTRSESAFDRARKALFEEGISSGKMYIDRERPGVEDVIDQIVAGLRSACTYAGAGSLEELHEKAVVGIQSSAGYDEGRPLRTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACE6</accession>
    <name>A0A011ACE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.737"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="237"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="439" mass="46432" checksum="A22A154C4152FF43" modified="2014-06-11" version="1">MSELSNDLRSGVRRGGVAVVQGLTFPVLGLGLGLPLFVLFVLSSAFLVLGIGFVLLPLVVVAIRNLATLHRRFAAEWAGLPIASPYRPAPAYSGFAPRRAGQRVRWMLRDPATWRDLLWLLGEVPVGLLLGLLPAVAVVSGVEGIVVPQVLWMLDVLPNGYGFGTVWPIETARDVGLAVSQGVLLVLIGLLIAPWALWAHSMYGRLLLAPTRKSQLALRVTQLTRTRTETVDAQAAELRRIERDLHDGAQARLVSLAMSIGMAEDLIGRDPDGAKALLVEARESSVLALSELRDLVAGIHPPILAERGLDGAIRALAMALPIAVECTVLLPGRPPAPVESALYFAASEALTNVARHSGAASAWIELESTGTHLRLTVGDRGRGGASIEAGTGLRGVERRLSALDGTLALSSPSGGPTVVLLEIPCVLSSPKTSRSFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACV7</accession>
    <name>A0A011ACV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848662.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_1_1_11"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="11634" checksum="DD946BE8750AE026" modified="2014-06-11" version="1">MPTYQYKCTACGHRLDAVQSFSDAPLSVCPECQGELRKLFSSVGVVFKGSGFYRTDSRSGSTSSEPAKSTSSSDSSSSSSTKSDSSGSSGSSGSSSSSGSTSSSSGSSSSSSSKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD06</accession>
    <name>A0A011AD06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939141_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="67"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="32505" checksum="002C7932717B1035" modified="2014-06-11" version="1">MTPFVRAEASPSLSYLPEPVHAVLNDLGVDLQVLESPPFAGPRRPVRRFVGGGVVVEVAETEPGRLRLRRELWGRQWARQVGIPTVPVLASDPDGTWVVAEWWRPGAPAGPEFLDDAVATALRVAGSPPPPPGPPPAQWTSPRRAAPLRLARGVLGGVPTRLWLAARRAAAGLPRVPVTHGDFYHRNALWCPERGGVHVVDWEYLGAGPRHGDLVRLWTLLPHRTDRDALRDRILALSPASEHREIGVLALYLALRLLGENVKGARADRHRADLNHARAIQPEARELARTLDAWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE71</accession>
    <name>A0A011AE71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849162.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1371"/>
    <dbReference type="HOGENOM" id="CLU_020336_27_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="34769" checksum="6312C5A4424821DA" modified="2014-06-11" version="1">MSRNRRLLFGSLGVLGALALITAYALRDPSPIGYFTSGEAQDRFLAAYDDAMDDLPAPDRTLDVRTSYGIVRVYHFAGAAPDEDPLVLLPGRASASPIWADNLPSLLRLRSAYTVDLLGEPGYSVQQRPITTPADHARWLHEVLEVLPEPRVHLVGWSIGGWTAANLAVHEPTKVASVSLFDPVVVFGNLSAQAVLRSVPASVKWFPKSWRDGFARWTANDAPVEDEPVARMIEQGMQSYVIKLSAPSRPSDGQLRNLRIPTLVIFGGESRMHDPDAGAENARRLLPNSTVKVYDDASHAVNAEYPDRLAADLKTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF30</accession>
    <name>A0A011AF30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2933630_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="60" mass="6698" checksum="E2234A5E5E9D042C" modified="2014-06-11" version="1">MPRYVSQLDPRGPFDGLPDVRRLLVLRGARRAGWPAPRSPGRLARYRAAVGAVSSRTLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG23</accession>
    <name>A0A011AG23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar biosynthesis/type III secretory pathway protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569989.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2036"/>
    <dbReference type="HOGENOM" id="CLU_103308_0_0_11"/>
    <dbReference type="OrthoDB" id="1911132at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="3">
        <location>
            <begin position="100"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="24685" checksum="ACBD93C2A5D6238F" modified="2014-06-11" version="1">MSSSPDPTATGVLRGAAADVAVSASFDTNLGRAGGRVPRVPAVDAELTAAKEAAKAAGFAAGWAEGRRAAKLEAEAARRLAEEETQRFDQARQAGLQRALQTVAAAANALEQRAAPSAMELENELVSAAFVLAEAVLGRELALADSPGRDAVARALELVPVGRPVLVRVNPADHATLTAEADHEGPLVIDGRTVTLEPDASLASGDAIAESDATVVDARLSAALLRVGEALGMVDATDQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGW1</accession>
    <name>A0A011AGW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570039.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2299"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="33445" checksum="1864430B2A060691" modified="2014-06-11" version="1">MNSDPRRVRLTAAGGPDVLRVEPMSVPEPGPGQLLVAAEAAGVAFNDISTREGLNPGPRPDVLGFDVVGHVEKVGAGVEDVVVGQRVGALVGVGGYATHVVVAAGRAAPLPEGRPAEELDALVLNYLTAWQMFHRVVEPAPGQAVLVLGAAGGVGSALCQIARAAGVEVYGTSSPARRARVEANGATWVADAAVVPVKVAATFDPVGGPSLARSRRATSRSGVVVSYGFSFATGAGYSRVGAMARTVGALVRAKLTPGARVAVHTVERVVDKDPAGFRADVTALVEQLEAGVLRPEVTVLPLDRAAEAHRRLQNREVQGKLVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH57</accession>
    <name>A0A011AH57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">carB</name>
        <name evidence="19" type="ORF">CryarDRAFT_2447</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850623.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2410"/>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_11"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="686"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="961"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="961"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="851"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EXG81336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1106" mass="117798" checksum="E33077945BF75700" modified="2014-06-11" version="1">MPKRTDIQHVLVIGSGPILIGQAAEFDYSGTQACRVLREEGLRVSLVNSNPATIMTDPEFADSTYIEPITPEYVEQIIAKERPDALLATLGGQTALNTAVALHERGVLEKYNVELIGADIDAIQRGEDRQRFKDICASVGAETPRSAVCHSMDEVRATVADLGLPVVIRPSFTMGGLGSGMAHTPEDLERIASAGLAASPTTEVLIEESVLGWKEYELELMRDRNDNVVVVCSIENVDAMGVHTGDSVTVAPAMTLTDREYQRLRDVGIAVLRAVGVDTGGCNIQFAVHPETGRLVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDEIRNDITRQTPASFEPALDYVVVKVPRFAFEKFPGADPELTTTMKSVGEGMALGRSFPEALNKALRSAETTAGGFWTTPDPDNDPLEALKTPHDGRLYDAERALRLGASVQEVSAVSGYDPWFVDQIASLVELRSELVDAPVLDAHLLGRAKRAGLSDRQVASLRPEFAGEDGVRTLRHRLGVRPVYKTVDTCAAEFAASTPYHYSAYETDPEAETEVAPSTGAKVLILGSGPNRIGQGIEFDYSCVHAAMSLRDAGYETVMVNCNPETVSTDYDTSDRLYFEPLTFEDVLEVWHAEDTSGKAAGGPGVVGVIVQLGGQTPLGLARRLAAAGVPIVGTPPESIHLAEERGAFGRVLEAADLPAPKHGMATSYAEAKKIAEAIGYPVLVRPSYVLGGRGMEIVYDDVTLESYIARATQVSPEHPVLVDRFLDDAIEIDVDALADGTGEVYLGGVMEHIEEAGIHSGDSACALPPITLGSADVENVRRSTAAIAAGVGVKGLLNVQYALKDDTLYVLEANPRASRTVPFVSKATAVPLAKAAARIMLGATIAELRAEGLLPPTGDGGSLAREQTPIAVKEAVLPFKRFRTITGAGVDSLLGPEMKSTGEVMGIDTTFGAAFAKSQAGAYGSLPTSGRVFVSVANKDKRSIVFPVKRLTDLGFEVIATHGTAEVLWRHGIPARVVRKHFEPAGGEDDHDVVTLIRAGEVQLVVNTPYGNSGPRVDGYEIRSAAVAADVPCITTVQAAAAAVFGIEAQLRGELSVRPLQELHRALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH58</accession>
    <name>A0A011AH58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">CryarDRAFT_2452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850630.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2415"/>
    <dbReference type="HOGENOM" id="CLU_125406_1_1_11"/>
    <dbReference type="OrthoDB" id="1864134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="92" mass="9919" checksum="66ED446B826CCC65" modified="2014-06-11" version="1">MAGTVAAPEGITNPPIDELLEKTSSKYALVIYAAKRARQINAYYSQLGEGLLEYVGPLVETSPQEKPLSIALREINSDMLTHEAVAEEGATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIE5</accession>
    <name>A0A011AIE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851176.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2828"/>
    <dbReference type="HOGENOM" id="CLU_044864_2_1_11"/>
    <dbReference type="OrthoDB" id="1107373at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="12"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28351" checksum="1B67B9EE28BC9204" modified="2014-06-11" version="1">MSTWTPAGPAWLFCPADRPDRYAKAAAAADVVILDLEDAVAPADKDAARRALAATPLDPGRTVVRVNAGDPTDDLRALRDTPYRRVMLPKAESAAQVSALRPFEVVALVESPHGALAVADLAAAENTIGLMWGPEDLTAALGGSSARYADGRFRHVHQQVRSTTLLAAKAHGRLALDTVHLDIADLDGQRAEAEDAVAIGFDGTVAIHPSQVPVIRAAYTPPPGEVEWARRVLEAARGERGVFRFEGRMVDSPVLRHAETLLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIE9</accession>
    <name>A0A011AIE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3078952_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="52" mass="6176" checksum="969D31A695084D25" modified="2014-06-11" version="1">MTEKKKRRRGEWLFQIFGPPTVNGALQGHSAEAREAWKRRVEQERAARRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIL0</accession>
    <name>A0A011AIL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exoribonuclease R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862470.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2927"/>
    <dbReference type="HOGENOM" id="CLU_038135_1_0_11"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040596">
        <property type="entry name" value="RNase_II_C_S1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18614">
        <property type="entry name" value="RNase_II_C_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="41"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="461" mass="48450" checksum="EA82D775E9CC9BA0" modified="2014-06-11" version="1">MRRLRAPAIDFGAIRSELGTPPEFSPEALAEAAAAPAESTRTDLTDVPFVTVDPPGSRDLDQALHLVPDGDGFLLRYAIADVAAFVRPGGALDRETTGRGVTLYLPDGRIPLHPPVLSEGAASLLPDQVRPAVVWTVRLAADATPLDVRIERATVRSRQQLSYPEVEAGARPEALTALEAFGTVRAERVLERGGIDLDVPEQEVERTGDGGWRLVLRAQTPAERHNAQVSLLTGECAAAMMLDAGVGLLRTLPPAGPADVERVRAVAPGLGIEWPSGASPGRVVASVDAADPRGAAFLDVAATLLRGSGYTPFIGGVPEQPFHAGVGAPYAHVTAPLRRLADRYATEVCLAVAAGAPVPTWVLEALPGLPTTMAGATRRAGEFERAVVDLTEAVLLAERIGEEFDAAVVDVSGEGKSGTVALDDPPVWAKCAGPGLRAGSRLRVRLLEADPTTRRVRFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIX5</accession>
    <name>A0A011AIX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">CryarDRAFT_3096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851489.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3057"/>
    <dbReference type="HOGENOM" id="CLU_061901_5_2_11"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21840" checksum="D4FA4757F54716AB" modified="2014-06-11" version="1">MSEPLADQVKTLLAAPRPWSVTQVGEAVLRRPAERYDGQLPDDLLALLLDAMREHLPGVGVGIAAPQLGIPLALAVIDDPAQVSPEVAAARERAPRAPLDLINPVVTPVGEERVAFYEGCLSVRGLTAVVSRSRRVVLTASDRTGAGYSQELTGWAARIAQHETDHLNGVLYLDRAELRSLSTTAAYEEHWAAPTPALAAAALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ52</accession>
    <name>A0A011AJ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851596.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3147"/>
    <dbReference type="HOGENOM" id="CLU_060077_8_2_11"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15710" checksum="509FD9851EFFA0CC" modified="2014-06-11" version="1">MVPIQEVARRSGLSEATLRYYERIGLIAPVPRDESSGHRRYDEDTAQAIEALACLRTAGMGIADMRAYLRGMSDGPDAARQQAELFEKHAAQLAEQIETLRSRQRYLDAKVLLWRAREHGDRGAEEQAIDAVTRAASELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK75</accession>
    <name>A0A011AK75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852111.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3507"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28585" checksum="B1FD03E1F09993E7" modified="2014-06-11" version="1">MIRAVSDHEIQPPGYAWSIDAAGLRVKAGKHRAVNDLNLSLSTGVHGLLGPNGAGKTTLMRALSTVIKPEDGVLRLLGTDARRSDGLRQLRTKLGYLPQHFGFYPKFTVRDYVEYMAWLREMPKRAVPAATQRAIDRVGLTDRADSRLKSLSGGMLRRAGIAQAIVNDPAVLLLDEPTVGLDPEQRVEFRGLLRDLGADSCVVVSTHLVEDVVAACTDVVVMAAGSSVFQGVPADLIRLGDDGGIGDSPAERGYSLLLQRHRDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM07</accession>
    <name>A0A011AM07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853148.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4177"/>
    <dbReference type="HOGENOM" id="CLU_044590_3_1_11"/>
    <dbReference type="OrthoDB" id="1979322at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="300" mass="33499" checksum="762AC0EDE70B40C8" modified="2014-06-11" version="1">MTYTGPIVDAHHHVWRRDDLEWLAGEPVPRIFGPYEPIRRDYLIDEYVTDATAAGITESVYVQTNWPLPRVLDEVRWLADVHAASGWPAAVIGAADLFAPAEDVLRAQAALSPLLRGTRHQLHWHERPEFRFADRPDALLDPVLARNLAVVADLGWLFELQVFPAQMADAATLVAAHPGLTFVLVHAGMLIPGEDEAWRAGMSRLAEQPNVVVKLTGQGTFVHRVDSGLLRLVTDTVLELFGPERALFGTNFPIEKLWTTMPTLVDAWRATLAGLPAEQQRWIFAENARRVYGLTPDRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFI5</accession>
    <name>A0A010YFI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_0002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847323.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2"/>
    <dbReference type="HOGENOM" id="CLU_038149_1_1_11"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="248"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="40263" checksum="5470E0F6F5F32480" modified="2014-06-11" version="1">MKFRVEREALADAVAWTAKSLPARPPVPVLAGVLLDTDNDRLTVSGFDYEVSSQMGVDVQTDTPGRVLVSGRLLAEITRALPNHPVELDADEARAEIVCGTARFTLPTMPVEDYPTLPEMPTVAGAVDANEFAGAVAQVVVAAGKDDTLPVLTGVRLELEGDRLTLLATDRYRLAVRELTWRPGAPDVSQHALVPARTLSDTARAMSSGTEVTLALSQGATGEGLIGFSGAGRRTTTRLLDGQFPPVRSLFPDSHAIQAKVPTATMVEVVKRVSLVAERNTPVRLAFTSGMLTVEAGGTDDARASESTDAVFDGDDIEIAFNPQFLLDGLNALGTEVAVLSCTTPLKPAVLTGEEADAESKPVNESAYRYLLMPVRVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFV0</accession>
    <name>A0A010YFV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.119"/>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="48"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26906" checksum="A6C925472FF2E7CB" modified="2014-06-11" version="1">MTDVNRQLWQERATGDVSRPWESLSTEPSGLREELWLRPAGADDDRVLLAIHGGGFVSGSIATHRRMFGHLALAAGISTLVVEYGLVPDHVYPAQLDQVSEAYRRLAGRRVALVGDSCGATLALGVAQRGPAPTAMVLFSPWVDLAITGASYDTPTDPFFTRELCRGLASAYLAGASPEPLDVSRLPPTYVQVGGDEALLDDARLLARSSPDVELDEFPGQLHTFQMAVGSSPVADEAIARAGKWLRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGI8</accession>
    <name>A0A010YGI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.379"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="26426" checksum="87DB86A30A31C13A" modified="2014-06-11" version="1">MDINLEGRVAVVTGASRGIGAAIAKTYVDAGAKVVITARRPEGLEKAAAEIGAPESVHAIAAHAGKAEDAERVVAETIERFGRLDVLVNNAATNPYMGPVIDAEIRAWDKTFEVNLRGPLVWTQAAYRGWMKEHGGSVINISSIDGLRPGGPLAIYGVTKSALVFLSQQLATEVGPNVRVNVLAPGLVKTDFARALWEGAGDDAKYPWPLQRLGQPTDIANAALFLASDASSWTTGAVLVVDGGGTLGGPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGQ2</accession>
    <name>A0A010YGQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_0485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848103.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.470"/>
    <dbReference type="HOGENOM" id="CLU_020931_0_0_11"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="430" mass="47687" checksum="58EB51E278B9A482" modified="2014-06-11" version="1">MSEPYDVLGIGIGPFNLSLAALAEPLSDVSAVFFDGRPGFSWHPGMLIEGATLQVPFLADLVTLVDPRSRWSFLSYLQQHDRLFPFYFAERLHVPRVEYDDYLRWVAESLPSCRFGRPVESISWDAAEQLFVAEVYDVLTARTTRVRARNTVVGVGTEPVVPAPLRPLLGKEVFHSAEYLDRQESLRGAQDITVLGSGQSGAEVFLDLLRHQRDGGYRLRWLTKAPAFAPMEYSKLGLEHFTPEYTRYFCSLPEPVRDALVPAQWQLYKAIDAETIDAIHSELYERTVAGGSVPVTMSPNVEVVGASRSENGITLECREVLQDRETTVRTDRVVAATGYTARPPVFLEPLESVIRRDAAGRFRIDSDYRVELDPGVTGGIYVQNAELHTHGVGTPDLGLGAHRAATILNALTGAEAYRLPSQTAFTTFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGZ0</accession>
    <name>A0A010YGZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569650.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.568"/>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_11"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="43451" checksum="9B2219C3999F6702" modified="2014-06-11" version="1">MFSSLSVRNYRLFAGGQIVSLTGTWAQMTAQDWLVLDLSHNSGTALGVVTALQFTPVLLLTLWAGALADRLDKRKVLIATQAASMLLALGMGALVVTGSAQLWNVYVFALLLGTVNAFDTPTRQSFISEMVGPDRLPNAVSLNSATFNSARLLGPAVGGLVIATFGTGPAFLLNGASYVAVLIGLFAMRPGDLLTGKRVERGRGQVAEGLRFVWGRKDLLLVIAMMSVLGTLGMNFNLTLPLLAKVEFDVGPASFGLLSAAFAGGALIGALIGARRTTRPSARWVLSCAVVFGVLECAVAFTPNFGIAALVLLFVGLAFIAHNNAANARVQLGTPAHLRGRVMSLYMLVFLGGTPLGSLIVGPISERYGPRAGLLLGGAAVLIAALTLAAARMRARNRETASERQKLTSVAAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH43</accession>
    <name>A0A010YH43_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_0636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.622"/>
    <dbReference type="HOGENOM" id="CLU_024186_2_0_11"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="11">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="12">
        <location>
            <begin position="328"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="483" mass="52243" checksum="575F9615A0640325" modified="2014-06-11" version="1">MSGLQLPPSAVDVDYGTLGWGSSRTMSDFEAGMWRLETAEPRLRSTIAAVDVLDTTPDWERLVAAHEWALGIVPRFRMRVVDPPFQLGKPVWSVDPEFDLGYHLRRVRLAEPGTFEAALELCRTIVDRPFDRARPPWEALLIEGLADGRAVYLLKTHHSITDGMGGMQLVTLLHSRRREPTPHKPTGVEPPPEHLSGLGALQEQLTDRVRTLPSAVTASVRTGLQFVRSPAAAIDFTQSLLRMAAPPACPPSPLMRSRGLGRRFGTLEATVDELRAAAKSADGSLNDAYLAALLGGYRRYHEALDAPVSELPIGMPISLRSSADSMGGNRFGVARFAAPVGVTDPAERIRRIRELVLDARAEPAADVLSLAAPALSRLPVAAVARWYLAQTSLIDLQASNVAGIPVPVYMAGARIDRMFPFAPAPGCGVMATLVSHTGVCCIGVTIDTAAVTDPDLFLSCLSEGLDEVLALGRRKPRKRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHI2</accession>
    <name>A0A010YHI2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmE2</name>
        <name evidence="5" type="ORF">CryarDRAFT_0774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848501.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.761"/>
    <dbReference type="HOGENOM" id="CLU_114306_2_2_11"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="82" mass="9448" checksum="E22E379B094A9BFF" modified="2014-06-11" version="1">MKPGIHPQYRPVVFRDRSADEAFLTRSTVSTDRTIEWTDGNTYPLVEVDISSASHPFYTGKQRILDSAGRVEKFRARYAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHP4</accession>
    <name>A0A010YHP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848545.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2355033_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="96" mass="9878" checksum="F52CEBDF2CE75A45" modified="2014-06-11" version="1">MKFAADTVTDLADTLGTDAGALARALQSDVLVDAPAILHALAVTALHLSTSAAEMAQAVDDVNGPSADELRAVQVAFAECSSTLLNIIEPVQRFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI55</accession>
    <name>A0A010YI55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085342_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="25050" checksum="17BEC84F3D142ABF" modified="2014-06-11" version="1">MAGPRRTPSGQRPSRAGGNRRPSTSSAARSAARNSTPRGTTPHGGRVTGRVPGKQRDYPVSSLPAQRRGAGRSPGAGSREGRRPGVRRTAASATAALDGRRFVRRGEGRFTGRAAVLAILFAVLVLTLAYPVQQYLAQRSQIAEAERAQARQNERIAALRSELDAWNDPEYVKGQARSRLQLTQPGEKRYVVQDPSRGNGGPTSTEPSGSPVNDPRSWYGRLWDSVEAADQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YID5</accession>
    <name>A0A010YID5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3327021_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="38" mass="4082" checksum="7C32F3EC27211DA8" modified="2014-06-11" version="1">MARIYSVGPTELRTLTAAGLVAFHDDLQLLTNERPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIW5</accession>
    <name>A0A010YIW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase involved in cell division</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1227"/>
    <dbReference type="HOGENOM" id="CLU_489768_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030994">
        <property type="entry name" value="DDR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040916">
        <property type="entry name" value="DDR_swiveling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028975">
        <property type="entry name" value="DDRA_swiveling_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08841">
        <property type="entry name" value="DDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18427">
        <property type="entry name" value="DDR_swiveling"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82317">
        <property type="entry name" value="SSF82317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDR_swiveling" evidence="2">
        <location>
            <begin position="101"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DDR" evidence="1">
        <location>
            <begin position="342"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="556" mass="55014" checksum="A0DE68278F133326" modified="2014-06-11" version="1">MPLRLVAGVDIGNSTTEVVLADVATGEPVAWDRTMTRGAKGTVSSVRGAAALVRRLVRRVPDGELVSAAVAPLRPVRTSTTTVPEPPADTGRFAVLAAGVASPGGVGSGVGRPVSIEEIEVPGGAPVVALVSAGYREAAPRLNALLAEGAPIVAVLLAADEARLVANRLEHPVPVVDGVDLAAAAGATLVAVEVVTAGRPLRKLTDPLFLASGFGVGAEENDDVRRLARQLADVSSAAVALGAVPVEPAGPAGGRIWTRRHPGGGEGLVWAEAARRLGEAEPGAFAAYAVDGGERVAVADLAVVDVGALAKSLLVRIGAGGGGYALAALDAAAGPVPADALLTEALGVPVVSASSEAAAARSGALTTPGAPADAVVVDIGGGTVDVIGPAHERVLAGGGDLLTAAVALGLDVTRGAAEWAKRGPAVRVETPQLATQEDGDKTFLEAPQPAGTVGWLAAPGPAGLLPITVRIGPAEWRTFRLALKQAVLGTAVRRGLVGAGTVLVVGGPAGDDEVLRVVDAVLPPGAGLGRGNVAGVLGHRYAVAWGLALAAGTTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK26</accession>
    <name>A0A010YK26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1645"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="362" mass="38530" checksum="E601B0ACD52043BE" modified="2014-06-11" version="1">MEAFRRHRASMVDALLALICAVTLVPATDSTLFGGSPYGIDAVPPVLVALGVGAAALVRRRYPLVLAAVALVGWVLAAAYPVVVLAQYTLGAHERSRRVVVAATAVVTVAVAVPFRRQGLDAVLPLSVAVCVAPAVLGLWLASRRAVLAGLRHRAERAEHEQRLVEARARADERARIAHDMHDVVTHRVSLMVLHATAAAVAGEPEKDRLVERIRLIGREALEELRTLVVVLHDDEEAPRAPQPRLADVEELAREAGVRYRVTGEPGSLSVLVEQTAYRVVQEALTNVRKHAPGAAAEVLIAHGDVLGVVVMNGPAARHPEPLPGGNGLLGLRERVRISGGWFHAGPSAGGFRVTALLPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK57</accession>
    <name>A0A010YK57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569929.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1675"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="23047" checksum="32C33A15E713F068" modified="2014-06-11" version="1">MGLRERKKAETRERIADVAAGLFAARGYDEVSVVDVARAAEVSDQTIYNYFPTKQDLVLDRAEEIRERYGRVVRERATGTSPAAALRPLVLEDIDRLRLEPPELARGEFPAQCLVSPVLRRFALEERERQADAITASLAATDPEVPTIVARAHAAALVSVVQTITDAIGAAVLASDRSDPLVARLIHDATDALDDLDRTFRSVTTARTGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKE8</accession>
    <name>A0A010YKE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849739.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1767"/>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28047" checksum="E22AA1FCF1D4BFD4" modified="2014-06-11" version="1">MSVPDAARALGGTEQPNAARMYDYFLGGSHNFAADRAAADGLLSVAPDARDNARENRAFLRRVIGYLLDQGVRQFLDLGSGIPTAGNVHEIAHARDPRARVVYVDVEPIAVETSRRLLADNPNAEIVHADLREPGAVRGRATLLDPAEPIAVLAISVLHFVPDADDPRTILGEYLEPLASGSYLALSHVVVDEAPPPESEDGLAVYARTATPVTLRDSRQVTAFFHGHPLVEPGLVPVSHWRADGPAEPSAIHGAAAKVQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL43</accession>
    <name>A0A010YL43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850085.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2342061_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="97" mass="10837" checksum="EADE753260DDAD11" modified="2014-06-11" version="1">MFARYSVLLLAALLAGPALWQAFVVGDLDMDTALIRYLIAVLVAAVMLGFLRMLYNTYQRIHEEHELERQLEEMRQAEAERRAAAEAAEAEGNGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLP2</accession>
    <name>A0A010YLP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ORF">CryarDRAFT_2245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850334.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2209"/>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_11"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="552" mass="57900" checksum="571B92FB9828E67E" modified="2014-06-11" version="1">MSDVAAGLLQLLALVVALGFAWKYLGDYMARVYDSPRHSRVETVVYRLVGVDADADQRWPVYLRSVLAFSAISVLGLYLLQRLQGHLPLSLGFAGIDPALAFNTAASFVANTNWQAYSGEAVMGHLVQMAGLAVQNFVSAAVGMAVAVALIRGFTRKGTDRLGNFWVDLFRGSFRILLPIAVIGTIVLVASGVVQNLASPHEVTTLAGNTQSVTGGPVASQEVIKELGTNGGGFYNANSAHPFENPNAFSNWFEIFLILLIPVAITRTFGRMIGDRRQGLAILGVMTTIFAGMLAIVWSFEARHPGLASQLAGSAMEGKETRFGVPGSALFAVATTGTSTGAVNSFHDSYSAIGGGAILLNMLLGEIAPGGVGSGLYGILIMAILAVFIAGLMVGRTPEYLGKKIQSREIKLVSLYILATPMAVLVGTGLAMAFSSTRGSMLNDGPHGFSEVFYAFASGGNNNGSAFAGLSANTPFYNTAIGLAMLIGRFLPMIFVLALSGSLARQQPVPVTAGTLPTHRTLFVGLLVGVILIVTGLTYFPALSLGPLAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMF2</accession>
    <name>A0A010YMF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase involved in chromosome partitioning</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2480"/>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="32475" checksum="39160C47A949123F" modified="2014-06-11" version="1">MSTNPVMSDDSGALEQATLDLATLGIVNEPRKARRAEESPQSEKSGHGPARVIALCNQKGGVGKTTSTINLGAALAEVDQRVLLVDFDPQGALSVGLGVNAYDLELTVYNLLMQSGIRTEDVLVKTNVAGLDLLPSNIDLSAAEVQLVSEVAREQTLDRALRQVRDDYDYILIDCQPSLGLLTVNALTAAHGVIVPLECEFFSLRGLAMLIDTIEKVKDRLNPDLELDGILATMYDSRTVHSRQVLSRVVEAFGDKVYETVISRTVRFPETTVAGEPITTWAPGSGGAKAYRALAREVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMJ8</accession>
    <name>A0A010YMJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850793.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2525"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458121" evidence="1">
        <location>
            <begin position="30"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="430" mass="45834" checksum="97B1D132DCD26E3A" modified="2014-06-11" version="1">MFKRRLAAVAVGTLLASTLAACGGGDSGGDTKTLTYWASNQSTSLEKDAEILKPELAKFEKQTGIKVKLEVVPWSDLLNRLLAAATSGQGPDVVNIGNTWSASLQATDAFVPFDDATLEKIGGKSRFVPAALAAAGAEGKPPTAVPIYSLAYSLYYNKKMFAEAGIANPPTTWEELVTYGKKLTTGGKWGLAIEGAHISENSHHAFAFSQQYGGEWFDKSGKATFDSPENAQAIKRYIDFIAVDKISNPGNAEYAQNQSVADFASGKAAMLLWQAVGSQLTLRNMPADDWGVAPVPFLASPPANGKKVNSMVAGINIAIFKHSKNQEGALDFVKFMTSDEEQALLNKTYGSLPSVTTVSDDPAFAKPEQKTIQDTLATSAAPLPQVAQESQFETLVGGLMKDLFAEAAKGKSPSVAEIQEKLKKAQEQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNW0</accession>
    <name>A0A010YNW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_2981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851314.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2941"/>
    <dbReference type="HOGENOM" id="CLU_025778_1_2_11"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="372" mass="39850" checksum="1C31EDA2913EDE34" modified="2014-06-11" version="1">MVVGVALFALGILLSLVLHEAGHLGAARMFGMKVTRFFVGYGRTLGSFRRGGIEYGVKAIPAGAFVSIVGMVRQFDESDDDPRAMWRFPLWKRTVVMTAGVAANVAFGTVLIWGMFAFTPLPDADRLQSEPVRVATVSDRSAAARLGLRPGDVVTTLDGRVIRGWDSFTRAVRASGGRTLEIGYRRDGRPRTGSAAIPLVDGAGQLGVTADVPRSAAGPVDAIALTGTQTATMVTGAFAALVHLPERVPAVWNSLTGDERDPEAPVSMVGASHLGGQLADRGEWPSFVLLLAGLNFFLAAFNLVPLLPLDGGHVSVWWFERGRSWLYARLRRPDPGQVDYLRLAPITYVAILIFAAFSLLTVAADVVNPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNZ7</accession>
    <name>A0A010YNZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851368.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2980"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="287"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="538" mass="55512" checksum="718A223740643567" modified="2014-06-11" version="1">MVSTSGTESGGKLSGLGVGQKILMSVAVIAVVALITGGLAWQRLGTIDGKIQKLQTENIARLNALVDMEAGLAKLYRGILNIYVAPTDTTSQQQIKDGEAAVSSAFAEFQKNPSDSAEWKKQVADFDEAFTTYTALANNILFKDPLPASVPAPANTAAMNAEFARVEKAFGVTLTALNNLEAEDSAADASDSHKTVVGARTMIAIVLVVGLLAALALAVIVSRAIISRLNHVQEVLDGVANGDLTRQARVDSGDEVGRMAEAVNRAIDSIRQTVSALSSSARTLADSSQQLTASAEAISGTAADTSAQTSVLASAAEDVSRSVQTVSAGTEEMGSAIREISQSANDAAGVASRAVDAAAQTNATVAKLGESSVEIGNVVKVITSIAEQTNLLALNATIEAARAGEAGKGFAVVANEVKDLAQETAQATENISKRVEAIQADTDSAVAAIEQISGIIAQINDYQMTIASAVEEQTATTNEMSRSIMEASTGSTSIADNIASVAAAAQTTSTTVGETQRSAEELSRMSSDLQALVSRFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPQ9</accession>
    <name>A0A010YPQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863219.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119494_0_0_11"/>
    <dbReference type="OrthoDB" id="1794812at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="15008" checksum="FEE46A59AA37911C" modified="2014-06-11" version="1">MSRRVRLRQLPERLTTGVFIVNSGLSKRHTDDDTAAALHGMAAAAYPFLRAIPPQRFVRLVCAGELALGTALLLPVVPPVVAGAALTAFSTGLLGLYLRVPGMRTEGSLRPTQQGQTLAKDVWMLGIALSLLVDGLGHDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQU7</accession>
    <name>A0A010YQU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852459.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3739"/>
    <dbReference type="HOGENOM" id="CLU_082329_0_0_11"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457908" evidence="1">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_red" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21279" checksum="DF49A6AB8F2328E9" modified="2014-06-11" version="1">MSSLKAVALCCSLKKSPAPSSSELIAREILTALADHDVEGDVIRVVDHDVRFGVSTDEGDGDEWPGIRARILGADILIVATPIWMGQPASVSKVVLERLDAELSETDDEGRLSTYGKVAVLGVVGNEDGAHHVTAEVFQALNDVGFTIPANGATYWVGEAMQSVDYDEAGPKPDTTGAATKSLAANAAHLARLLRASRYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR81</accession>
    <name>A0A010YR81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570634.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040631_0_0_11"/>
    <dbReference type="OrthoDB" id="1175812at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045394">
        <property type="entry name" value="Abhydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20091">
        <property type="entry name" value="Abhydrolase_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_10" evidence="1">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="48539" checksum="DAD3C25B33327D83" modified="2014-06-11" version="1">MTVTALELLPAGPPGAGPALGLAAAGYREEEYLVRGVADEWGYDASGRAELRRRDVPYTTRFVLRRPADDDRFNGVLQVEPLHPEYDAALTWQALHGWILRTGGAWAGVTQDFRLAEWLRTDVDAERYGELSIPAANLRYEIVADVAEALRGEGWGARARTYLSGWSMTGSFGRVFLGDGFHARRRLAGGAPVFDGYVIGISSGGAGASGYPGLSDEWEVPADDPRRTIADHDVPVVELLSELESETHEPHLRPDGDRYRLYQVAGTAHDALGPRPGGTAAIPIVERPSNARLDLIARAVFARLDDWVRDGVAPPHADRFTYDDDHRPARDAEGNVLGGVRTPWIDEPLARYVPHSTPAVTEVTPSPWSPVADPQLMAWLRGHLVPLDPPVLAGRYASAEDYLARYAARCRALVEDGFLRWEDTETLLATATAQFLECPRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRR5</accession>
    <name>A0A010YRR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PqqA peptide cyclase</fullName>
            <ecNumber evidence="7">1.21.98.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coenzyme PQQ synthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pqqE</name>
        <name evidence="9" type="ORF">CryarDRAFT_4114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:56836"/>
            <dbReference type="Rhea" id="RHEA-COMP:14800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:141026"/>
            <dbReference type="ChEBI" id="CHEBI:141027"/>
            <dbReference type="EC" id="1.21.98.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PqqD. The interaction is necessary for activity of PqqE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the radical SAM superfamily. PqqE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.4" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852972.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4087"/>
    <dbReference type="HOGENOM" id="CLU_009273_4_7_11"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009975">
        <property type="term" value="F:cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00660">
        <property type="entry name" value="PqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011843">
        <property type="entry name" value="PQQ_synth_PqqE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00280">
        <property type="entry name" value="coenzyme_PQQ_synthesis_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02109">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="38624" checksum="EFB09105045FA9B4" modified="2014-06-11" version="1">MADPFGLLAELTYRCPLSCAYCSNPLNMAEYTDELTLPEWQRVFTEARDLGVLQCHLSGGEPLLRRDLVALVASANALGLYTNLVTSAIGLTRPKAEQLRDAGLDHVQISIQADAPSLSDSIAGLPSFRRKVDAMRVVKELGWPLTVNVVLHRQNIDRVAEVLDLAEDVGADRVELANTQYYGWAWRNRDALLPSRAQLEAAEQVVRAARDRLSVIYVVPDYYSDYPKPCMGGWAARQLTVTPNGDALPCPAAQSLPLPTASVRSDSLARIWNESPVFTAYRGTGWMPDPCRSCDRREVDFGGCRCQAFQLTGDAARTDPVCHLSPDHAVVTDAVAAANSVVDLQLVPRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YS06</accession>
    <name>A0A010YS06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853175.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4181"/>
    <dbReference type="HOGENOM" id="CLU_001681_8_2_11"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="452" mass="49717" checksum="6765349FA779831C" modified="2014-06-11" version="1">MTTIDRDYFRDERPGSFHVIGSTVQRADARGHVTGRTAFFEDTIPPGLTHLKIHRSTRHHALIDRVDVSKAYDVPGVLRVITAADVPSNWYNVLRLIGIEPDDEPVLAEDRVLYRGEPIVAVVATTEEAAREGAARIVVDYTDLPPVFDVEEALTAPAFKRSGTNYFVYEGHHCRRVRFGDVEAGFAAADHVFSWRYGSAPIEHAPTETTGCVVVPQGNGRLRIHSNTQACFFTLDNTALIIDRPFTDLQVVGGTVGGGFGGKVDVMVEPLACIAASLTNRPVKFVYSREEEMQVSSPRAAERLYITDGVTNDGRIVARKVVLYVDAGAYQRHSPYGTTKAAAHLPGPYAIPNVYVDAHCVFTNRTPSSAMRGFGVTIADFALESQMDRLARELGIGPLEFRLINAYRDGDMKAHRKLAEGTALIEVVQRAADLVGYPLSPEHRALSSRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV20</accession>
    <name>A0A010YV20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS sodium solute transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847347.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.16"/>
    <dbReference type="HOGENOM" id="CLU_018808_9_3_11"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="560" mass="60043" checksum="A96EC2DBCC2FFC73" modified="2014-06-11" version="1">MTTDLAATLDVNAIDYTILGIYFAIVIAIGLLARRAVATSEDFFLSGRALPAWVTGLAFVAANLGALEILGMAANGAEYGIATVHFYWIGAVPAMIFLGLVLMPFYYSTRVHSVPEYLRRRFNAPTHAFNALSFAVASVLTAGVNLYALGLIIQSLLGWPLWLAIFVSAGFVLIYITLGGLSGAIYTEVLQFFVILAGLIPLVIVGLSAVGGWDGLKDKVSENTDLGASAFSQWGGTGVGDATNPLGDWIGIVFGLGFVLSFGYWTTNFAEVQRALSAKDLSAAQRTPLIGAFPKIFIPALTIIPGLVALVLIPQLGKEGGPTYNDAIPELMAKFLPNGVLGIALTGLLAAFMAGMAANVSSFNTVFTYDLWRPYVVKDRPDRYYLQVGRIITVIGIVIGIGTAFIAAGYENIMNYVQALFSFFNAPLFATFIVGVFWKRMTAWAGFWGLVSGTAAAILAYLSLNNKLGIPEIVFIESTQSRNFWGAIAAFVVDVVVTVIVTMLTKPKPIDEVKGLVWGVPDPDNPDAADAQNVRRWWESPKVLGFTALGITAVLSIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV98</accession>
    <name>A0A010YV98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847510.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.91"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_11"/>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="136"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="37195" checksum="96C352EBC741069B" modified="2014-06-11" version="1">MAEPLRVALLGYGTAGASFHAPLIAAVDGLTLSAVVTSRRDQVLRDHPGARVLADAEEVWAARTSYDLVVVATPNHTHLPLARAAIDARLPVVVDKPLAGRAADARELVKRAEKAQVPLTVFQNRRWDGDFRTMRRLLTSGAVGHPLRLESRFDRWRPAVATDAWKESAANAGGILLDLGTHLVDQAITLFGPVRSVYAEIDARRPGAAVEDDVFLALTHASGVHSHLWASALAGQLGPRFRLLGDAGAYVTWGMDPQESALRAGRKPGSPNFGERPADEWGKVGAGDAVRPYRTLTGEWTRFYEGVVTAVTTGAPMPVDPHDAVRVLTVLDAARRSASARTVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW36</accession>
    <name>A0A010YW36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="20032" checksum="E48E91C0B1C14B4C" modified="2014-06-11" version="1">MDRRERTRELGRELRRYFVEARLVTHAFAELHGLHATDLHALIEIMDAEGRGEPTTPGRLGEALGLSSGATTAVVDRLERLGHIRRERPAGDRRRVHLHYDEGGRELALEFFGPLHERIYRVVGEFTEEEVAVAHRFLTAVTDAAADHRRAVRDNSDRSGQADGDAAGRGGRPQADGVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWB3</accession>
    <name>A0A010YWB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569623.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1413892_0_0_11"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="73"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="22435" checksum="30E8A96B768BCDDB" modified="2014-06-11" version="1">MTDPLDALRDPGAPQSPDPEFADALRRRLREALDRPIARRQGRPVPIEDDRLDELLEFAVEQFEEDLMTLPITIKQFSPYLAVVDGRRAIDFYVAAFGAEVVDEPTIMPDGKIGHVTLQIGPLRLFLAEEFPEMGLQAPPSLGGVSVTLHLSLGSAGDVDTVAQRAVAAGATLDRPVADGPYGRAGVIVDPSGHRWFLLHEPEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWL8</accession>
    <name>A0A010YWL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569653.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.576"/>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="196" mass="21024" checksum="C4B4976195E909DB" modified="2014-06-11" version="1">MARTAGSTAEGTRQRILDAATKLFEQRGFAGTSIRDLAVLCGMTKAALYYHFPSKEEVLQALITPFLDDVDRIVAATAAGQWSRAELVKRLITQMNERGEFLTAVLSDPSVKHTMFERLGMNARMERLLQVLAGSDDPAALLRGRCAMGALMSGLLHHQSPGQAGPLLSSAEQSVVCAAVLAVLDSEDPVREAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXD7</accession>
    <name>A0A010YXD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
            <ecNumber evidence="3">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848618.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.868"/>
    <dbReference type="HOGENOM" id="CLU_001681_2_2_11"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="699" mass="74785" checksum="DF5527233B953942" modified="2014-06-11" version="1">MTLSPTRPGAIGTPVARVEGPLKVTGTARYAVEYPVENVVYAWIVQSPVARGTLTAIDAPESGDVLTTLWHGNAPKLSEADDPELQVLQSPTISYRGQVVALVVARTLEAARGAAQSVELSIEEEEHDVLLTPDHPRLYTPEKVNPAFPSDTSSGDVEAALADAAATVDVTYETPALHNNPMEPHATTALWVDDDLVLYDSNQGPSAIASQVAKVFGLKKDQVHVVAEHVGGGFGSKGSARPNAILAAMAARVVGHPVRLALPRQALFTMVGHRTPTIQRVRLGATADGVFTAIAHDVVEHTSQLFEFAEQTAVVTRHMYAAPNRRTSHRLARLDVPTPRWMRAPGEAPGMVALECAVDELAASLGLDPIELRIRNEPDAEPEDGTPFSSRHYVECLRLGAARFGWDTRPLRPRQRREGRWWVGTGVAGATYPSMVMPSTATVRIDASRNVLVEVAAVDIGTGSRTVLHQVAADVLGVPLENVTVRIGDSSLPRASIAGGSSGSASWGWAVDGACRKLREEMSRLTGPVPADGLSASFDTGPDVRSRENSGKHAFGAHFAEVRVDADTGEVRVSRLFGQYAVGRVLNPRTARSQFIGGMTMGLGMALHEESVLDVTTGDWVNHDLAEYHVPAHADVEWIDAAWLDEEDSSVNPLGVKGIGEIGIVGSPAAIVNAIWHATGVRVRDLPVRLDKLLTDPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXL2</accession>
    <name>A0A010YXL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A core-O-antigen ligase-like enyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848702.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588905_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="464" mass="46495" checksum="63671309553D7BB5" modified="2014-06-11" version="1">MTGPPVRAALPLIAVALVFAGPAVGDRPLPGTGGTLEVIHLVCVSAIAVTAAWVLAGRLPVGAVLDRRTTVAPLWFGAGLVAAAAASTLVAANPLRGTKVTATYAAGLLLLVAVLLVATSPARLRALVGTAVVGSLTVTLPILSQAEQLKPVYGGAVVRNRAQSIFADPNQFGCYAALIVLLAVGWFLAAPHRWERVLAAGGGAGAAAALVLSLSRGAWLGTAAGLIVVALMHSAVRRTLLAGAALGATLVAAGVLVSLTAPTEVRGGPAAGLVEVVADRIAVIDDRAANPHDVRPITWREAVRQFRLHPVLGNGPGSFSTLAAESPSVIQFAPRLHAHNALLHIGAETGVVGLFAGVGFAGSCGLSALVSARRLRRAAAGTETEAGAGAGAGPHAEAEPAVGAGAARRALGLVAGSTGALTALSVHLMVDYPIRNPVLMITAWSVAGLLLAAGRTASRDRVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY11</accession>
    <name>A0A010YY11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725665.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1134"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="480" mass="47895" checksum="74DECEC21FF16D95" modified="2014-06-11" version="1">MPSRVVLVPIALAAFVTSLDNTVVNVALPSMQRDLALGVSGLQWIATSYILAFSALLLAGGRLTDLYGRRRVFLVGIGIFVTASALGGIATSGDFLIATRVLQGIGAALVLPSTLAVLATDVPSAARHLGAGVLTASIALSLALGPVVGGAVAEHWHWSWIFFLNVPVGLFTMVLGARTIGGSRASGQPVDVGGLITSTSAMFAVTYALIEGSVVAGGLAVAGGASFVVVERFAAAPMVDVRLFASRVFSGGTAAQVLWGLGINGVFFFTSLFLQDVMRLGPTAAGAMFVPLAVALVVCVPVSAALATRAGVHRTVAGGMALIAAGLIWVSFVGRGDPAWALVPGLVLVGVGSALTTPLTSAVLEVVPPASAGVAAAVISAAREVSGVLGIALVGAVVTVRSAAGASGGAGPVDAFASGYTAGLWCAAALTALGGAISLVALRPEVVGATRGDRARRPVPARRLGTSAAGRGRRPGRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYI6</accession>
    <name>A0A010YYI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1299"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="34440" checksum="706C78F3CA4A5646" modified="2014-06-11" version="1">MVVNKLMWREEVPTTTITSEAEKPAAPSHRVLTLGDIAGRESGGLVVLLVAVGALTLASDTFLTGGNLANLARQVAIFGIIAVGQLLVILTAGIDLSVGSVLGLSGAVTAQLLVAGWPVLVAIAVGVAIGAALGLANGLLVTRAKLPPFIATLGMLGIARGVVLVITDAKTVQGLPEGFQEIANGTVLGVPNLLLIAAAVVLIVWFVLTRTVFGRYIYAVGSNPESARLAGVPVTAVTISVYAISGLLAGLGGVLLTSRLGAGIPTAGTGFELNAIAACVIGGASLFGAKGGALGAATGALIMGVLNNGGNLLAINAFYLQIAIGVLILVAVGFDQWNSRMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0W5</accession>
    <name>A0A010Z0W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850244.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2381350_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="94" mass="10055" checksum="11468B67386B8822" modified="2014-06-11" version="1">MTEPEKTPRIVRVITPEDHHAVETTHARTASPAELLAGKVRGGEAEHVEVVVEYCEGPTGTHQFTVDLGDGAPLVIPAEPPVEEWLLAHGVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1T8</accession>
    <name>A0A010Z1T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850693.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2463"/>
    <dbReference type="HOGENOM" id="CLU_058015_2_0_11"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="27873" checksum="157B1F6440442EC8" modified="2014-06-11" version="1">MARRTRLDAELVRRGLARSREDAATLIAAGAVKVDGRVAAKAATAVDPASAVTVTEDTGPKYVSRGGHKLAGALEAFQVPVKNRRCLDAGASTGGFTDVLLRAEAAHVVAVDVGYGQLAWSLRTDDRVTVIDRTNVRTLEPEAIGGPCDVTVADLSFISLGLVLPALAACTTPDGDLVPMVKPQFEVGKERLGAGGVVRDKSHRVEAVLGVANQAATMGLGVAGVVASPLPGPSGNVEFFLWLRRDAPAVDPEAVRTAVEQAPEPGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z242</accession>
    <name>A0A010Z242_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sortase-like acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2571"/>
    <dbReference type="HOGENOM" id="CLU_013985_4_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17590" checksum="2E5C202919B3C172" modified="2014-06-11" version="1">MIDAMAERHAAQVLEIYRAGIATRQATFETVVPPWAEFDAARLPGHRFVELDGTDVVGWVACSAVSRRPAYAGVVEHSVYVRPDASGRGIGGRLLDALITSTENDGIWTIQSAVFPENHASLALHTRRGFRVIGTRERIGRLDGVWRDTVLIERRSPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2P0</accession>
    <name>A0A010Z2P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2770"/>
    <dbReference type="HOGENOM" id="CLU_1616267_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="16286" checksum="3EB7567F5737CF5F" modified="2014-06-11" version="1">MSDVAAMDSFLAVVFGLAALYAGGVIFVVSAGRQGPQRAAANGAGAAAGVAAALVLMVLLAHVAVAALVAAVVLFSGAIAYFVLVRDIGRRPAALTAVGAAALISLSFLLVSYLAVLAFIGAAGIYLLLRLWVRTRPALLVMGGTLSGLLAASGVVFAVALSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2Z2</accession>
    <name>A0A010Z2Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851204.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2850"/>
    <dbReference type="HOGENOM" id="CLU_059523_0_1_11"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="33188" checksum="E318538CC04F73AB" modified="2014-06-11" version="1">MITIGSAPDSWGVWFADDPAQTPADRFLAEVKAAGYDWIELGPYGYLPNDPVALTEALEAHGLRVSAGTVFSALHRPDSWDAVWRQVTDVASLTRAVGGQHIVVIPDLYRHHKTGENLESPTLTDAQWTKLTTDTNELGRRILDEYGLTLQFHSHADSHIGYQRDIERFLADTDPAYVNLCLDTGHVAYYGGDSLELIGRYPERIGYLHLKQVDPEIAKQVEAEDLVFPEAVRRGVMCEPPNGVPDLGAVLDAVGTLGRDLYAIVEQDMYPCEPERPLPIARRTHTYLAGCSGAPVSIGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z301</accession>
    <name>A0A010Z301_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851219.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2860"/>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_11"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="469" mass="49561" checksum="2E3E225C1C0B7B4A" modified="2014-06-11" version="1">MSFLSALDRRHTVAPEGFSRWLIPPAALSVHLCIGQAYATSVYKNSLVAHFDVSQTAIGIIFSIAIVMLGLSAAVAGTWVETNGPRKAMFVSACFWGTGFLVGALGIATEQLWLVYLGYGFLGGIGLGIGYISPVSTLIKWFPDRPGLATGLAIMGFGGGALIASPASRQLMSFYDSGYDPSDAKSIADGHALVMLFLTLGIVYFVIMMFGVVNIRVPREGWRPEGFDPAAVAAKPMVTTASVSAANAIRTPSFWLLWIVLFCNVTAGIGILEQASPMIQDFFRDGDASAVGVSAAAGFVGLLSLFNMGGRFIWSSTSDVVGRKRIYMLYLGVGILLYVLLASVGDSATWLFVLLAGVIISFYGGGFATVPAYLRDLFGTFQVGAIHGRLLTAWSAAGVAGPLIINGFLDAQGEPGSLTSSAYRPALFTMVGVLAVGFVANLLIRPVAEKYHEKSAPTEPTAETEEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z673</accession>
    <name>A0A010Z673_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852741.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3967"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_11"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="35630" checksum="B176DDF505E375C9" modified="2014-06-11" version="1">MSRATLRDVALLAGVSPKTVSRVVNREPGVTEAKVTAVTAAIEKLGYRPNFTASSLRRAGGRTATIGVVLENVANPFSSSLHRAMEDVAREHGVSILAGSVDEDPARERDLINIFAGRQVDGLVVAPASGNQGYLTTELLAGTPVVFVDRPPVGIQADTVVIDNRAGARRAVEHLIAHGHHTIGYLGDLRSIATARDRLQGYRDALADQGIRPGPVVEDVHTEREAEQAVHRMLAGSRPPTALFTAQNLVTIGAIRALRALRRQHAVALVGFDDFPLADLLEPGVTVVAQDPTAMGRLAASLVFRRLAGESGEPAVHEIPTRLIPRGSGEIQNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6A3</accession>
    <name>A0A010Z6A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570682.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3997"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_11"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="511"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="627" mass="68825" checksum="2724ADF751A64D93" modified="2014-06-11" version="1">MTALRAYLDWLEKREGRRFGDHDALWAWSVEDLDRFWLSIAEYYDVAFSARWSEVRSAEPMPRTRWFPGARLNWAEHALRRGADGDPALLCVSEGGGADPRVLTYAELRRSVAAAAAWLRREGVRPGDRVGAYLPNTEHAVIACLAAAAVGAVWSCCTPDFGADGTIGRLAQLEPTVLVAADGYHWNGREIDRREVVERLRAALPTLRRFVAVPYLGHPVPAGATPWEELLATDAPPEFAPVEFSHPLWVLFTSGTTGLPKGLVHGHGGITLEGLKWAGLYCGLRPGERMFTYTSTGWALWNMQLGALSHGATIVLYEGSPAGVVWEIAERTRADVMMLGAAVITASVPPPRPLRRLRHLLVSGSALPREGYRWVWEHVGADVRIDSTSGGTDVSGAFVGSNDDSPVRPGRIGGRLAGVDCAAWDEDGVPVVDDVGDLVVLQPMPSMPVHLWNDPDFTRYTESYFETWPGVWRHGDWVTFHSDGGVTIHGRSDSTLNRQGVRLGTGDFYDVLEALPEIAETLVIGVEQPDDGYWLGLFVVPAPGHTLDDALKRTIVATLRTRLTARHVPDEIVEAPGVPHTLTGKRLEVPVKKLLRGTPLERAANPASVDDPAVLRWYERFAAERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKG7</accession>
    <name>A0A010ZKG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847601.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2449659_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="2">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="89" mass="9433" checksum="02AF106CAC2A6CCD" modified="2014-06-11" version="1">MTEFEALGPNAGVTIVKSPEGIHEFRDGRVQFTDHEPLSPAEIVTPTGAGDAFAAGYLAGLLLEDESPSPAARGLSFARRSLRTPSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKL5</accession>
    <name>A0A010ZKL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.209"/>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21865" checksum="59883B2350080115" modified="2014-06-11" version="1">MDFGSSSPGRPPRVTASRATSAKIVIAGGFGVGKTTLVGSVSEIRPLTTEAVMTAAAIDVDDASKIPGKSTTTVAMDFGRITLDEDLILYLFGTPGQTRFWFMWDELVRGAIGAVVLVDTRRLADCFAAVDFFEQRGLPYVVGLNCFDGIQPYTTQDVRDALTIGQEVPIINCDARGRESTKALLISLVEYVLRLRGAAPAGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL65</accession>
    <name>A0A010ZL65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860138.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.413"/>
    <dbReference type="HOGENOM" id="CLU_139818_0_0_11"/>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="116" mass="12363" checksum="02BE30EE4B8C2FEF" modified="2014-06-11" version="1">MAQKVQVLLVDDIDGGDAEETVSFSLDGVSYEIDLSAKNAATLRDAVAPYVGVARKAGRAQATKAAAATRVRSSGSTATADREQNQAIREWAKKRGFKVSDRGRIPSDIVKQFHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL90</accession>
    <name>A0A010ZL90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848065.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.448"/>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_11"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="16994" checksum="B65F834FA6D00C1D" modified="2014-06-11" version="1">MTEHDVTFTVNGVPRTASVPARRLLADTLRHDLGLTGTHLGCEHGVCGSCTVLVDGRPMRSCLLFAVSVDGAEITTVEGCRTPEGGLGPVQQAFVDCHGLQCGFCTPGFVTTITAYLEENPDPTEDEAREAIGGNLCRCTGYQNIVKSVLRAAELKKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLI6</accession>
    <name>A0A010ZLI6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine transaminase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohydroxythreonine aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848267.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.562"/>
    <dbReference type="HOGENOM" id="CLU_061974_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="137"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="369" mass="39404" checksum="0BDC29265C4BBB18" modified="2014-06-11" version="1">MTITIPAELLPADGRFGSGPSKVRPDSIDALVATGRSFLGTSHRQATVRNEVARLRAGLATLFALPDGYEVILGVGGTTAFWEAAVFGLIRDRAQFLSFGEFGAKFAKAAKVAPFLGDPTIVESAPGDAPVFEFEDGVDVYATPHNETSTGVAIPVRRVPGDHLMLHDGTSAAAGLAVDVSETDVYYFAPQKGLGSEGGLWLAIMSPAALERVERISASGRYIPAFLDLVTAIDNSRKDQTYNTPALTTIFLAAEQVDWFNAQGGLAWTTQRTTESARTLYEWAESSSFATPYVKDPEKRSHVVGTIDFAESVDAAAVAKVLRANGIVDTEPYRKLGRNQLRIAMFPGIDPTDVAKLTASIDYTVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMF0</accession>
    <name>A0A010ZMF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848619.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.869"/>
    <dbReference type="HOGENOM" id="CLU_058050_1_0_11"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="33995" checksum="CAB69949B7133672" modified="2014-06-11" version="1">MKTFTYRAVTDIDEAVAQTGTYLAGGTNLVDLMKLGVTAPETLVDINQLPLHDVVRRPDGGLRIGAGVRNSELAAHPVVRRHYPVLSQALLAGASGQLRNMATTGGNLLQRTRCRYFMDATKPCNKRVPGSGCPAREGDHRNLAVLGASEACVATHPSDMAVALVALDAVARVTGPNGERTIPIEVLHRLPGDRPHHDTVLEPGELITAVDLPVLGRPSAYRKARDRASYAFAVGSVAACLQLDADGRVDDVRLALGAVAHKPWRARAAEEALRGGPATREAFLAAADAELAAAEPLRDNAFKIPLIRNLVATTLEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMI3</accession>
    <name>A0A010ZMI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amino acid aldolase or racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.914"/>
    <dbReference type="HOGENOM" id="CLU_042383_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="2">
        <location>
            <begin position="119"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="499" mass="53729" checksum="D6FA3B902BFBB2D4" modified="2014-06-11" version="1">MARPGDPPSELPGQEGFSDPLDAPDDRPTVPVEAAEPAPDRTSAPITQRRRRPARHDFGTPQEAETGVRVASSARADHAPYTPEPVGETDPPRSTTPEAIFARLEAATAHLEPPFAVLDRTAFRANAVALTRRAAGTPIRIASKSLRCRTALIEALSLDGFAGVLAYALPEALWLAEGDGASAFSDVVVAYPTANRAALAQLIRSARLVERVTLMIDSVDHLDLIDQIAPPGRRPELQVCLDLDASLKLGRFHLGVRRSPVHTAADAAVLARRVALRKGFRITGLMSYEAQIAGVGDNPGRFLRALAVRWMQRRSWADLLERRAKMVEAVRSTLEQVNRPPLRFVNAGGTGSIEKTAADPSVTEVAAGSGLYGPTLFDTYRAFTPRPAAMFATQVVRRPARGWVTVAGGGWVASGEPGPDRVPTPVYPPGLTFSPTEMAGEVQTPLQGEATAYLKLGDRVWFRHAKAGELCEHVDVLHVVDGDRVVDVVPTYRGEGKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP37</accession>
    <name>A0A010ZP37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">CryarDRAFT_0004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569510.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4"/>
    <dbReference type="HOGENOM" id="CLU_040267_1_1_11"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG78992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="43346" checksum="39CC3CB04B4A5D75" modified="2014-06-11" version="1">MSTDRAGTPNRQGGTYVRHLSLVDYRSYTAVAVDLDPGPNVFVGPNGQGKTNLVEAIGYVSTLGSHRVATDAPLVRAGATRAVIRAAVVRDARELVVELEIVPGKANRARLNRSPVSRPRDVLGALRTVLFAPEDLALVRGDPSERRRFVDDLLVARSPRFAAVRADYDRVLKQRNALLRTAASARRASRGTSGGDLRTLEVWDGHLATHGAELLAGRLEVLGALEPYVAKAYDAVSAGKGRTRLAYRSSTHGDAVSDTPEPVAERPEFNVDVPTLTQHILSALAEARSQEIERGITLVGPHRDDVVLWLGELPAKGYASHGEGWSYALALRLGSYELLSADGGEPVLILDDVFAELDSQRRERLAALVGDASQVLVTAAVAEDVPPALQGARFEVAAGEVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQH4</accession>
    <name>A0A010ZQH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569981.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459153" evidence="3">
        <location>
            <begin position="30"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="35403" checksum="E112F2ACDAADFAD1" modified="2014-06-11" version="1">MDVRHRRRLPALAAVLLAGLLLAGCSSSADDGDSSSESGRPQAASAPRSAPDQRSGGTGTGPTQLGTASRPLVYTGTMAVTAGNVPDAARKAIAAAVAAGGYVAADERSVTGPDDDISATLTLKVPSTKFTGTIDALAKLGTETSRNLGTEDQQTASIDIDARIAAQRASVNRVRALLQRATTITELTTIERELTTRESELATSEATKRSLRDQVSYSTITLSLAEPSAPPKPEPKQERGLLVGLENGWSAFVTSVVVLLTIVGWLAPFLIGFAIVGVPIWWALRRYRPRRPAPVSPAPSALHHAHRAPVPPFPPQAPVSAPSSSVPSAPSSPAPPEGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQK7</accession>
    <name>A0A010ZQK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar motor switch protein FliN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850097.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2024"/>
    <dbReference type="HOGENOM" id="CLU_097058_0_0_11"/>
    <dbReference type="OrthoDB" id="1875967at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="7">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="24826" checksum="D96985CB7BF7A8BB" modified="2014-06-11" version="1">MTASTEAAASVLARVGAAATAALPLLPAVDPLTAGEPQVVPDSGGLVGQGVLASFSGAAQGQLLVAVSQDLVDALAESPMGALDLTQALQPVAEAAAGTLGAVIVEQGIPVPDLEAGLTALSESGDAAFVLLSDDSGVRALIGLLITSVTSIASGGGGGGAPAPMQHGLDLLHGVEMDVTAELGQTRMTVRDLLSLTPGSVVELDRLAGSPADLLVNGRMIGRGEVVVIDENFGIRVTEIITPDSDRPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQU0</accession>
    <name>A0A010ZQU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoglucanase Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.605"/>
    <dbReference type="HOGENOM" id="CLU_036185_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="485" mass="53158" checksum="1EF6F945A3835F5F" modified="2014-06-11" version="1">MPATAPYVYRRTEDEGPRARRRRLERRRRRTAALASGVAALLIGSVPVVSSLLRSEPEGHGRGGGTVTGERRSAPATPRPAPHSSGSAQGEALYPQGSQGSVGVPFGSLRRAHYRGAVIRPSGPQTDLNEAVVAYYRQWQAAFVRQRPCGQDWAAVASPDAELPYVGEGQGWGLVVTALMAGADPNARQQFDAILRYVMAHPSSIDPDLHAAEQNERCESVNGGDSATDADLDIAYGLLLAHEQWGGTTYLELARRRIEAIKRSIVDPKSHLVRAGDWARDGDDAVSRISRSSDWMLGHFRAFRTVTGDPFWDVVLDAHLGLITRLQAEYSPGTGLLPDFVERINRTPRPAHGEVLESEHDGSFWWNACRVPWRIGTDAVLSGDPRSVAAAAHLNTFARTTTRDDPTRIKAGYTLDGRVLADYTEPAFVVPFAVPAMLDRNGQHWIDAEWRYLTSTPVRADAYYPATIGLQVMLVLTGNWWTPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQU9</accession>
    <name>A0A010ZQU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_3_1_11"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="28514" checksum="CF8727A310CF83B1" modified="2014-06-11" version="1">MLAGHSLSPQSRYEEVTVTRVDVVAVTHRGLVRGRNEDTLAVAGFLSGAFENEPVRLEVNTARPVSFLVADGLGGHVEGFRASRLAAALLSDATPELHDEETIVAAVRGASDAVFAEMAHNPDWYGMGTTIVGLVLDGDRAFCLNVGDSRCYRVGDDGSLDQLSIDDSPPLDPASGRRFTTIVTQTLGGTRQESVIHPHVSVHRVVPGDRFLLCSDGLTDYSEPEALPAALANPHADPVDSVNALLHAAFEGGGKDNVSIVLLKVAEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR18</accession>
    <name>A0A010ZR18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850301.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2184"/>
    <dbReference type="HOGENOM" id="CLU_030955_0_0_11"/>
    <dbReference type="OrthoDB" id="1909652at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458058" evidence="3">
        <location>
            <begin position="26"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="52309" checksum="7CDC45F046D92912" modified="2014-06-11" version="1">MIGRILAVLVIALVGVLMPGTPAQAHPLGNFTTNQYAGLRISSTGVDVDFVLDLAELPAYQARTIDIDTDRDGTASSAENDTYAEHTCAAAAAAAAVTVGGRNVRLTAEPAGLTFPAGAGGLTTLRLHCTLRADARITTTTAIGYRTTLFADRIGWREITALGDRYTITRSDVPAASVSKRLTAYPTGAVSDVRSATLAVRPGGPAAVDSLAPTGATQARGVDRFTTWFTSLIGHPQLTLGVGVLAFLIALVLGGAHAVAPGHGKTIMAAYLVGSRGRAREALTVAGAVAATHTLGVLALGVLFATSLQLAPDATYGWLRLISGILVTLVGAHLLHQALRRRRVVAVTHDHHTDELVPAGHLAAHPHSHAPHSHAPRTSHVHSHGGSPHTHHLPGPGESPNVRSLLAMGFAGGLSPSPSAVVVLLGAAALGRAWYGVLLVLAYGIGLAATLTGIGFALAHWSERLYRFGTGRRGTLLTRRLPTATATLIVLVGLGMTFLAVPQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRE3</accession>
    <name>A0A010ZRE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850447.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2287"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21596" checksum="A0DC5394D973B409" modified="2014-06-11" version="1">MTTVVLADDEALLRKALAALLPLEGDITVLAEAADGSSAVEETVRHEPDVLVIDLEMPGVDGLGAVAEIRRTRPEQVILMLTRHARPGVLRKALKLGVQGFVSKSAEPSHIASVIAALHAGKRWIDPDVSALAVVDDCPLTDRELDVLRVTGEGYSVAAIAARLDLAPGTVRNYLSNAMQKTQTRTRHDAARYAREHDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRI9</accession>
    <name>A0A010ZRI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848597.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.847"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_13_11"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15611" checksum="F8658BC4A6DECBB2" modified="2014-06-11" version="1">MAVDPRLRELALLRRVRDRIDREYAEPLDVEALARGVHLSAGHLSRAFRAAYGESPYSYLMTRRIERAMSLLQRGDMSVTEVCFAVGCSSLGTFSTRFSELVGMSPSAYRRQKGAHAEGVPRCVAKQVVRPVRNREASPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRM7</accession>
    <name>A0A010ZRM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117052_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="21352" checksum="19BF73CC7F9F36C0" modified="2014-06-11" version="1">MAPRDLVHRYLKVGTISIDAVRPRLWSQSVDATHYSGSGEKYQMAILEQYRIYTEMADRTSARRGLTNTFFLTLNTLVFAMIGTFWQHRPTGAAWYLVFPLCALLVQCAAWFWLVRSYRQLNAAKYVVIGVLEERLPASPYWQAEWKALGEGKDTALYWPFTHLEQWIPASFALIYSSAFTVALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS89</accession>
    <name>A0A010ZS89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate dehydrogenase</fullName>
            <ecNumber evidence="6">1.17.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CryarDRAFT_2660</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850911.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2624"/>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_11"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="17">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="16">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EXG81544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="925" mass="99357" checksum="75AE05D6D51DA577" modified="2014-06-11" version="1">MTLLKEPDFGTPAKPGDPTVTVEVDGLPVAVPPGTSVMRAAAQAGVNVPKLCATDSLEAFGSCRLCVVEIDGRKGTPASCTTPVGDGMKIRTQSPHLERLRRGVMELYISDHPLDCLTCPANGDCELQDMAGEVGLREVRYGYEGENHLDAPTDTSNPYFDFDESKCIACSRCVRACDEVQGTLALTIANRGFASKVAPGPTSFLDSECVSCGACVQACPTSTLQEKSVVELGMPSRTVITTCAYCGVGCSFKAELRGTELVRMVPHKDGGANEGHSCVKGRFAFGYATHPDRVLNPMVRESITDPWREVSWDEAISTVARGFRSIQDRHGAGAIGAISSSRCTNEEVWVVQKMVRAAFGNNNVDTCARVCHSPTGYGLKQTFGESAGTQDFKSVALADVIVVIGANPTDGHPVFASRMKRRLREGAQLIVIDPRRIDLVRSPHVEAAHHLQLTPGTNVAIVNALAHVVVTEGLVSDDFVASRCEGYDEWAEFIAAPENSPESVERITGVPAASVRAAARLYASAGNGAIYYGLGVTEHSQGSTMVMGLANLAMATGNVGRDGVGVNPLRGQNNVQGSCDMGSFPHELPGYRHVSDDVVRGQFESQWDVSIRPEPGLRIPNMFDAAIDGSFRGLFVHGEDIAQSDPNLQHVSAALSAMELVVVQDLFLNETAKFAHVFLPGASFLEKDGTFTNAERRINRVRAVMPPKTGKAEWEIVSEIATAMGYPMAYSHPSEIMDEIAAMTPTFAGVSFEALDKLGSIQWPCNASAPEGTPIMHVESFTRGLGKFVRTAFVATEERTTRRFPLVLTTGRILSQYNVGAQTRRTGNVAWHPEDLLELHPHDAAERGIGEGDRVTLASRVGETTLRATISERMPVGVVYTTFHHPITGANVVTTEHSDWATNCPEYKVTAVQVSLSAPIPAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSM1</accession>
    <name>A0A010ZSM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1263"/>
    <dbReference type="HOGENOM" id="CLU_073856_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458266" evidence="3">
        <location>
            <begin position="34"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="35826" checksum="703C03DD444A5B5A" modified="2014-06-11" version="1">MTLAPRRRFLVTAVSVFAVLCALLVGLPHSASAAEDDEGGTASLRKKLDQAASGYNNAKAKVASSQKRQKSLVSQIAATEKRLTALTSEAQLLGAEAYKGGMPDPLTVLANSGSAGELVERAGYMETISRKTNGTLTELRSTQKKLKAQREQVDKELKLQRQQEKTMAKRRADAEQALVEAGGGDSSAGFLSGTSAAAKPAPRNSDGSWPGESCSIDDPTSGGCLTPRMLHTYNEARSDGFTHYTHCFRQASFGEHPKGRACDFAADSGGFGGVASGDSKAYGDRLAAWGVDNADRLGVLYVIWFRQIWLPGSGWKSYSGDGTPSGDHTNHVHISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT66</accession>
    <name>A0A010ZT66_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">CryarDRAFT_1480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849265.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1453"/>
    <dbReference type="HOGENOM" id="CLU_061463_3_0_11"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="11517" checksum="CC32BE6C68D869C3" modified="2014-06-11" version="1">MYAIVKTGGKQYKVAVGDVVEVEKISGAPGDAITLPALLVVDGEGDKVDVTHEAAKLAAFTISGEVVAHTKGPKIKIHKYKNKTGYHKRQGHRQPLTQIKVTGIESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTE6</accession>
    <name>A0A010ZTE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3024499_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="55" mass="6070" checksum="95A6CA6989278F35" modified="2014-06-11" version="1">MGKHAAPDPERLGCRHRITRGALHPLTHIVTLVGLHVAALTVIEKTPLLTFLFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTW8</accession>
    <name>A0A010ZTW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851741.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3244"/>
    <dbReference type="HOGENOM" id="CLU_033716_1_1_11"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="43828" checksum="8241892E4310360A" modified="2014-06-11" version="1">MTETETETALVDFPLRQPGQSFPPESYAGYRQQDRLVRSKLLNGAIVWLVSRHEDVRAVLSDPRISSNPTHQGFPNAQRTGGVPSTDEVPGWFVALDPPDHTRFRKALIPEFTVRRVRDMTAAVQGIVDDRIDAMLAAGDTADLVSDLALPVPSLVISSLLGVPRVDRDFFEAKTRVLVTMSSTDAQREKAAGDLLRYLTRLIAIKRRRPGDDLLSRMLANGDMTPEEMSGVGMLLLIAGHETTANNISLGVLTLLQNAEWIGDPRVVEEMLRFCSVADLVALRVAVRDVEIGGQLIKAGEGIVPLVASANHDAAVFAHPERFDPGRPAHGHVAFGYGVHQCLGQNLVRLEMDVLCRTLFTRIPTLELAVPVEDLPYKYDGVLYGLHALPVRWQRDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU30</accession>
    <name>A0A010ZU30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851845.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3314"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="35068" checksum="472BDAF82AEE8945" modified="2014-06-11" version="1">MTGYLARRITSGALVLLGLSIIVFALFYLAPRDPAALACGKGCTPERLAEVHTAMGLDDPVPVQYAHFLRGVFVGRDYSSGPDVRHCGAPCLGYSFETDQPVSSMITERLPVSASLALGAEILALILGVGAGLLSGRGRFQFLRRAVNGFVLVGFAVPVFLWGLALLLLFCVRLQWLPFPSYVPLTDDPAQWAQNLILPWIALALIQSAGYARLTQAGVEGALAEDFVRTARAYGLSERRILRTRALRSALIPLTTLTAIDLAQMMTNAVLTETMFGLPGIGQLLVGAVTTIDLPVVVGVTLVAGGVVIIGNTVAEMLLAAVDPRVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUY1</accession>
    <name>A0A010ZUY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type xylose transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3660"/>
    <dbReference type="HOGENOM" id="CLU_037628_13_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459242" evidence="1">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="43"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="366" mass="39144" checksum="6D43A663916DCB84" modified="2014-06-11" version="1">MPFATRNVSLPWLSLALVGTMLVTAACSDSTSGDIAAPDRGVVGLAMPTKGSARWIGDGENMVKQFTLLGYRTDLQYAADDVQTQIDQIDAMVERGDKALVVGAINGSALKDVLAKAAAADIPVISYDRLIRDSGDVDFYATFDNYRVGVLQGSYIVDALGLKRGRGPFNLELFAGSADDNNATFFFNGAMSVLRPYIGRGRLVVRSGQTSFAAVATQRWDGTVARQRMARILAASYGSARLDAVLSPYDGISRGILEAVKAAGYRGSQLPVLTGQDAELDSVKLIAAGQQGQTVYKDTRELAKVAVQMTNSLLTGGTPEVNDTKQYNNGVKTVPTFLLQPVNVDKSNYRRVLVEGGYYTADQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV34</accession>
    <name>A0A010ZV34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase, hydantoinase/carbamoylase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850220.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2128"/>
    <dbReference type="HOGENOM" id="CLU_024588_6_0_11"/>
    <dbReference type="OrthoDB" id="829830at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="406" mass="41924" checksum="B9F9AC48DEF14392" modified="2014-06-11" version="1">MTGFDQLWRELRPIGRVAGSGGYQRFSWTPADLSGREWFASTAESVGLSVEVDRNGNQWAWWGAPGAGAVVTGSHLDSVPDGGAFDGPLGVVSSLAAVASLTARGLSPSRPLAVVNFVEEEGARFGLPCLGSRLLTGAVSPSRARDLRDPSGVTWAAAMDAAGLDASGIGADPDRLGLIGTFVELHVEQGRGLVESGSAVGVASAIWPHGRWRFEFAGEANHAGTTRLADRRDPMLTFASTVLGAREQAALAGALATFGRVSVEPNGTNAIASLVRAWLDSRAPDESSLARVVEAVTTLAAERGDRDGVKVTVTAESTTPVVEFNADLRDELAVLIGAGDAAGRAPILPTGAGHDAGVLSAHVPTAMLFVRNPTGVSHAPGEFATPDDCALGVEALSAVLEHLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVE2</accession>
    <name>A0A010ZVE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852599.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3831"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_11"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="30366" checksum="54DC9FB035F95276" modified="2014-06-11" version="1">MAATLDGVTHHTAGALHYVSAGTTGSPILLVHGWPETWWAFRGVIPLLAAHHRVFAVDLRGFGDSEADPGGDHDVATLAEDLHRLVAHLGVGPVHMTGQDVTGGPVFRFAATHPGDVLSVTAVETTLPGYGLERLADVLNGGSWHVGFLAAPGIAELFLAGRERTMIDWAVDLMTAVPGAVTEADLDEFVRTYSRPGGWRGTQGLYRSLLDDAARTRALAESQPLTMPVLAVDGINAPLTETTMRQVTRGDVRAVTIPGVGHLVAQEAPAAFAATVHEFVGSVDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVS3</accession>
    <name>A0A010ZVS3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ORF">CryarDRAFT_2412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850586.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2375"/>
    <dbReference type="HOGENOM" id="CLU_087936_2_1_11"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="20342" checksum="B8A488BA4CB719BA" modified="2014-06-11" version="1">MIASVRGDVAAVGPDGAVVEVGGVGIAVHCTPATLSGLRIGSSTRLATSLVVREDSLTLYGFATDDERMIFELLQTASGVGPRLALAVLAVHSPDAVRVAIASADTAALTRVSGIGKKGAERLVLELRDKIGSVDPVAVPGLAPAGGWQESVRDGLTGLGWSAKEAEDAVVLVAADFEGRPVEVATALRRAIQVLGKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVS4</accession>
    <name>A0A010ZVS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD, TfdA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852688.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3931"/>
    <dbReference type="HOGENOM" id="CLU_041041_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="38941" checksum="55FC37C7019E9C7C" modified="2014-06-11" version="1">MQPIDGPFAWRGSDLAERKDWIVELTAAQVEELRSVGERFVEDDPDLRTVTATDYPLPHCADAVAAFGDALDRGRGFVLVRGLPTETYDDALAGAIFYVMGLHLGVPMRQNELGDLLDHVIATSDKTLAEADALPSRVRDRLDFHSDSSDVVALMCLRAAKAGGASSLVSGATLVNEMLARRPDLAALLLEPWYFDWRKQDPDAPADYYTSPIVSWTGGVFSMYAGTSMIRSAQRHEGVPALSPEQNEALDLLDAITHEPGIALDMDFRPGDVQWLLNYAALHSRTSFVDHPEPGRRRHLLRLWLQRDVGRPLVPGFGKHVVAGREEARTEDDSRGHFHIADAVVPRQDWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW65</accession>
    <name>A0A010ZW65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme PQQ biosynthesis protein PqqD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852971.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163864_1_0_11"/>
    <dbReference type="OrthoDB" id="2008640at2"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022479">
        <property type="entry name" value="PqqD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03859">
        <property type="entry name" value="PQQ_PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="86" mass="9825" checksum="BD52EEE752EF01C9" modified="2014-06-11" version="1">MTRPKLARHCRLGFDRTRQRPILLLPETVVVLNTTGAAILERCDGRRTVDEIVTDLGEAYREVPGAEVQRFLNGMLERRFVEMVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW84</accession>
    <name>A0A010ZW84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850814.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2555"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29719" checksum="C4E102233145CF76" modified="2014-06-11" version="1">MGRVEGKVAFITGAARGQGRSHALRLAQEGADIIAIDVAEDIPSVTRFYPGATEADLAETVAQVEALDRRIVASKVDVRDYDALKGALDTGVAELGHVDIVSANAGIFLHSDKTHEVSDSDWDDVLDINLKGVWHTVKAAIPHLIAQGTGGSIVLTSSTAGIKGTPNVAPYTASKHGVVGLMKTLALELAEHNIRVNSIHPTGVATDMILNETTFKLFLPDEEHPTREQAAPVFQSTNALPVPWVEPIDISNALLFLASDEARYVTGLELKVDAGYTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWB3</accession>
    <name>A0A010ZWB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853059.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4140"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="30541" checksum="E81005FDF6D017E0" modified="2014-06-11" version="1">MAISTLPGGDWSLGDLRVSRFGYGAMQLAGPWVMGPPADHAGALAVLRAAVELGITHVDTSDAYGPHVTNRLIREALHPYPDSLHVVTKVGARRDARGGWPAARDPESLRRQVHENLDHLGLDVLDVVNLRLGDAQGPVAEPVAAAFATLVELQQQGLIRHLGVSNATPEQVAEARAVAPIVCVQNRYNLAHREDDDLIDALAADGVAYVPFFPLGGFSPLQSDALSAVADRLGSTPMSVALAWLLRRSPNVLLIPGTSSVAHLRENVTGAGLELSADDVAELDKIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWY4</accession>
    <name>A0A010ZWY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_2846</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2808"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="315"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="41300" checksum="2022AB4DBDFB3D04" modified="2014-06-11" version="1">MTLGTAAIAATDGSRRWLWPWDAYVAVSVAALIALVASGSETTSTRQGLSIACLALIGLSWAVIGRRFARADDDADSPDRPAALAYVAGVVVVFGVCVASDGISSFALFAVCPIAFLCLRLRSAFVAIAVLNLAPIPINGLREASLDAARDTIGIAVLGLTFTALIGASIVNVGRQSAERARLIAELEASRAEVAALSHQAGVAAERTRLAADIHDTLAQGFTSIVTLVQAAETELDTDRGSADRRLALAVRTARENLAEARAMVTVLAPAELGTGTLVEVIEKQVARLGEETGVDATCAVDVPPVLPTRVEVVLVRTVQEALTNVRKHAGAATVTVDLITHDGAVTLTVDDDGAGFDAGAARSGYGLSGMRSRVEQLGGTLTIRSAPGAGTTVTCEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXK4</accession>
    <name>A0A010ZXK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851472.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3037"/>
    <dbReference type="HOGENOM" id="CLU_101141_5_0_11"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="14776" checksum="AF836D91F41BE401" modified="2014-06-11" version="1">MFEWSTKVRYMECDAQGVVFNGWYLTYFDEAFAAFLTHRGLSYAELTGSGYDAAVVRTELDWKTGLGYGDEPAVAVSTATIGRTSFALDFEVRRDGEVTCSARTVYVVIATDGSGKREIPPRLAEALGDPAPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXN2</accession>
    <name>A0A010ZXN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570255.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3069"/>
    <dbReference type="HOGENOM" id="CLU_030181_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36131" checksum="C630D9A9925E08E6" modified="2014-06-11" version="1">MTTPEFRLRATDDVDLIAIVPYLLGFHPADSLVTIGVDEGRVQLTTRVDLPPTTEDASTEPFLHTAERTAAQIAATSFEAIVIGYGSADRIAAAARPLAAALTAAGVALRRMIRVDDHRYYCVTPGCIKCPPEGTPYSVAKSQLPAQATYAGMVVLPSRDSLDELIAPVTGPEQERMHVASLTALRHLATRLPAEDRNAVSAVPAELLTEGKHAVDDALHAAADGQPLSDEAAAMLHAFLLIPPVRDYAAAACDGSSAQRALWTDLTRRAEPDLAAAPASLLALTAYLGGNGALARVALQRALTAEPDYRIAHLLDDVLSTGIHPNELRRFTNTRNDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXW7</accession>
    <name>A0A010ZXW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851605.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3154"/>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_11"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="16688" checksum="C78B8650DB523DEC" modified="2014-06-11" version="1">MNVQPRLNLPKAAPQAARALYTAEQAIRTSPLDPTIRELVKLRASQINHCVHCVDLHTHEALELGETPNRIYQLVAWRESALFTPVERAALEYTEAATTLSPHGVSDEIWAGVRNVMTDEELGALVVQVALINAFNRFGAPLQMPAKIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY77</accession>
    <name>A0A010ZY77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ORF">CryarDRAFT_3312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851783.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3269"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_11"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="635" mass="68234" checksum="69BD4EFA93A18001" modified="2014-06-11" version="1">MPKAVGIDLGTTNSVIATVEGGQPTVIANAEGSRTTPSVVAFTEDGERLVGQLARRQAILNPKGTIYSAKRFIGRRFDEVSSELNAVTFDVVPGPDDAVRFEVRDKLYAPEEISALVLRKLVEDASKFLGERVTEAVITVPAYFNDAQRQATKDAGRVAGLEVLRIVNEPTAAALAYGLDKKEHETVLVFDLGGGTFDVSLLDVGDGVVEVRSTAGDTHLGGDDFDRRLVDHLADEFQKTDGIDLRRDPQALQRLFEASESAKVELSSVSQTTVNLPFITADANGPKHLNLTIARAKFEDLTNDLVERCLGPVQQAMSDAKVTANDIDEVILVGGSTRIPAVQKLVRRLTGGKDPNMTVNPDEVVALGAALQAAIIKGEVKDVLLLDVTPLSLGIETMGGVMTRVIDRNTTIPARRAETFSTAADNQPAVDVVVLQGEREKADDNRVLGRFRLENIRPAPRGEPHIEVTYDIDANGILNVSAKDEDTGAEQRITISESSNLDSSEVDRMVRDAERHQGEDARLREMIDARNELDSAAYQVERRLKDLGDAVPVHEKGRAEMLVGDARQAIKDDAPLDRLRTLTAELRQVYQSLGAGSGPASGGSNGGPAADGSSSRGDSSGSQDDDVIDAEFTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A084</accession>
    <name>A0A011A084_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852952.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4073"/>
    <dbReference type="HOGENOM" id="CLU_016472_0_2_11"/>
    <dbReference type="OrthoDB" id="389495at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="444" mass="48445" checksum="C088AF1D550C2ACA" modified="2014-06-11" version="1">MPNPYLAGAHAPVSREITLTDLTITGALPESLTGRYLRNGPNPIGEIDPETYSWFTGDGMVHGVRLRAGRAEWYRNRWVRGPLAASKLGEAERPGSGEAGMDLAGANTNVLAYAGRTLALTEGGITNLELDYDLDTVGPCDFDGTLTGGYTAHPKRDPATGELHAVSYSFARGDQVQYSVIGVDGRARRTVDVTVGGPVMMHDFSLTENYVVLYDLPVTFDLDRAMSGEPGIPYSWKPGYRTRIGVLPREGGDADVRWFDIEACFVFHTLNAYESGDRLVIDLARHPKQFDADDEVDGTISTLERWTVDLRAGTVTCTALDDRHQEFPRIDERFAGRRHRYGYTMALTPGASTLNTTLLRQDLVSGATRSRDFGPGTAIGEFVFEPASPDAPEGHGYLLGFVSRLADDTTELAVLDAETLDPVAAVHLPVRIPTGFHGNWLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABA1</accession>
    <name>A0A011ABA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1425842_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="19584" checksum="41F499280BE00672" modified="2014-06-11" version="1">MADRDETVRASLPALRTFGADVKSAGQDDLVTGLGNNFAVTMSQHVLGFMGTGTGSGTHPVAPMGEAVYFGHLMADYAQAAGRFAGDVVLGLVALGFAAEGIATQYSDGDALSSATIEQVSDAFVPQLGDSQPVAEATEEKPADSKKTAQDPTGYHAGTPERGERPPLPGGGPDVPDAESADYQNRPFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC52</accession>
    <name>A0A011AC52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848374.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529605_0_0_11"/>
    <dbReference type="OrthoDB" id="1863545at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="48838" checksum="D400721568B2FB6C" modified="2014-06-11" version="1">MRLPVLLRLAVTGGRLDGLRIALTAFGAVLATLLLLSAATVLAIEGDADYTNGLLAEPGLRPGVVTALMLLGIPVLFFVGQCVRVGAPARDRRLAEYRMAGATPGQAIKLAATETGVSAAVGMVIGFAVFLLGRVVLDRSDPPRPLPTDVLPSWWALLLIALVVPLGGAALAALALRRSTLSAFGVVRNRPVKAPRIAPAVMFFGGGTALVSLVYLDRFVNEGISGLVGLLVFLLLIVTLLGLVLGGAALSAWIGGRVASRAKSPALLLAGRRLVADPWAASRTLPTVFAAVVIGAGALTMRAGWAADRAAQARLYPSDSGAENPFYDRAFALTQLAVWVAVVVAAGGLLVATAEQILERRRTLAALTAQGTPTGVLARALLWQTALPLIPGVVLATAVGAITARVVASPVSSYSQEDATGRMVEVHLENLTPWLGLVVLVVGTVLVTMLVCALGLLLLRRATAVDELRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACD9</accession>
    <name>A0A011ACD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type spermidine/putrescine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569702.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.732"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="8">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="36655" checksum="34DDF6CA6DEF9862" modified="2014-06-11" version="1">MSLDAHLLVDRGTFALDVAFTAEPGQVLGVIGPNGAGKTTLLRALAGLTPLTGGRIELAGRRLDDVPVEDRKVGVVFQDYLLFPHLSALENVAYGLRVRGVRKAEARAAAHEWLDRFGLAGHAGKRPGGLSGGQAQRVALARALAVDPDLLLLDEPLSALDAGTRLRLRTDLRTHLTSYRGPSLVITHDPIEAMILADRLVVLEGGRIVQEGSATEVTRRPATDYVARLVGLNLYRGTAADGHATLDAGGAFTIADRTLTGPVHVAVRPSEIALYRSEPTAGSPRNTWRGRIVGVEAWGDRVRVAVDGEPPTLVDLTPDAVADLDLAAGHTVWLTAKASSITAYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADP8</accession>
    <name>A0A011ADP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217447_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="37" mass="3805" checksum="D6F03222EACD7111" modified="2014-06-11" version="1">MAASLSRLRDNTGVSYLAVDAAAMEALAPVVERLAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE99</accession>
    <name>A0A011AE99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Astacin (Peptidase family M12A)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1408"/>
    <dbReference type="HOGENOM" id="CLU_522466_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="2">
        <location>
            <begin position="48"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="521" mass="55112" checksum="8566C5C3A489E5DC" modified="2014-06-11" version="1">MSETGVGYVYGETFGVRRVVFSVEDGRAIFEGDIVLGPVSEVSARSAVAIPGESFRWPDGVIPYEIDPALPEAQRSAVEEAVEHWNTRTRLAVVPRDGEDDYVRFVPGGGCTSSVGRQGGMQTLDLGTGCFFGQATHELGHAAGLWHEQSREDRDEFVRIVWDNIDPGQKHNFDQHITDGDDVGPYDYGSIMHYPAVSFSVNGEPTIVPLRDGAQIGQREGLSAGDRAAIRELYSSLEPSDANTWVGSFGVLYHLRSRGTYHLGSLATGALTWTEVGHGGPGPVGDFDGDGLDEVLDAAGGRIGRLVEGQLSWSSATARVLGSQSWVGRFRPGGADEVLTYYPTDHSWWLGPSEWSYAGNTEGFTADLSTLLVGDVDADGVAELLVADGGEWWCAKLGAAGEFEWSVVGETVGRALGVTSGGLLVSTGDSTLLGSLVDGALTWRPVGAAGPAGSLVGGRYVTSPDGVWSFDGSTWTSLDGATGDVAWALGDGRVLTYSVLDASCRLYTPGAGWSSVATFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEB7</accession>
    <name>A0A011AEB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1428"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="24544" checksum="33D05A84C5FF6606" modified="2014-06-11" version="1">MKVLVVEDDADLGYAVAAALRGAGLAVDLVGDIPAADEAVLISPYACVVFDRMLPSGDSVDYVAARRRGGWDTPVLFLTARDSVADRVAGFEHGGDDYLVKPFAVAELVARVLSLGRRSLTTGPPAAPVLRVVDLEIDVPRRQVRRAGVLLTLTAKEFAVLELLANHAGEVVSRTTLIEHCWDAMAEPMSNVVDVLVRQLRRKLGGPQLIHTVRGAGYLLGQDPAAPAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEH5</accession>
    <name>A0A011AEH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">CryarDRAFT_1515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849323.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1488"/>
    <dbReference type="HOGENOM" id="CLU_038009_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="204"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="32599" checksum="37B19C8C4BB5A1CD" modified="2014-06-11" version="1">MSDFHAGFACFVGRPNAGKSTLTNALVGTKIAITSSKPQTTRHTVRGIVHRPDAQLVLVDTPGLHKPRTLLGQRLNDLVRTTWAEVDVVALCVPADEPVGRGDKFIADEIAGLKKKNVLAIVTKTDLVDKKRLAEQLLAVSRLGEFAEIVPVSAKAGDQVDLLADLLAKYLPESPPLYPDGELTDEPEMVMVAELIREAALEGVRDELPHSLAVVVEEMEPREGRDDLLDVHATVFVERPSQKAIVLGAGGERIKHVGSTSRRQIEALLGTRIFLDLRVKVAKDWQRDPRQLRRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEU9</accession>
    <name>A0A011AEU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1616"/>
    <dbReference type="HOGENOM" id="CLU_040923_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="29437" checksum="FC9E595E5311EBEB" modified="2014-06-11" version="1">MARQNLSATRIKPRLAEPLTMHVLRRRQVSPHFARVTLGRGDVERFVPMGFDQWFRLFIPVSDASLAKVPQKLNTMAFLKYLTTSKVDRPTLRSYSVRAYRDAGPGGPELDVDFVLHGDGAAGPAATWAATCAEGDPVAIIDEGVGFNPPDGLRRVRLVADESGLPALAGVLASLPADTTGDAIVEVPSTEDEQELIAPDGVGVTWVVRDAHATPGRAALAAATALATPAEPFYGWVVGEQSLPTGLRRHWVNAGVPKNHIMFCGYWRAGRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFN9</accession>
    <name>A0A011AFN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110186_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13076" checksum="9243659F27F40289" modified="2014-06-11" version="1">MSSTAVGPPSTASFGRRAAAFLVDGVLCAMVAGLFTYPAPPGGWSTAVFLVAYTAFIGLFGESPGMRLLKIHCQGIADGRPIGLGRALLRTVLIILLIPALLITSDGRRWHDKVTGSLVVPNNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFR7</accession>
    <name>A0A011AFR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849987.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1930"/>
    <dbReference type="HOGENOM" id="CLU_170329_3_0_11"/>
    <dbReference type="OrthoDB" id="1855714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="95" mass="10216" checksum="C174428390F5846A" modified="2014-06-11" version="1">MITSIVMISCETDSIPEVAQTLADLPGVSEVYSTAGNVDLIAIVRVHQFDDIAEVIAGRINKVPGIVDTETHIAFRAYSRHDLDAAFSIGLEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG69</accession>
    <name>A0A011AG69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-dependent enzyme, putative carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569996.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2080"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_11"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="188"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="417"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="579" mass="59468" checksum="06EA3A8707C27CE7" modified="2014-06-11" version="1">MKPVDALLEILRGEGVEYVFGNPGTTELPLLDALVDAPDLRYVLGLQEASVVAMADGYARATGRTAFVNLHVAAGLANGLIGLLNASRSRTPMVVLAGQQDRRHLRADPMLSGDLVGIAAPVAKSAVEVHQAYDLPVLLRRAFALARRPPAGPVFVSVPMDLLEEDGPVAVPEPSRVAGLPAATALGDAVSLLSGASAPVVIAGDGVGREGAVPALVAVAERLGAVVWSQPMFDGVNFPGGHVLHRGMLPPRDASIRAALEPHDVVLIVGCHAFMPHHYTPGPAIPDGTAVVQLDSDQHEVGRNFPVAAGLVGAIGPTLGALDTALATAFAAGPADQAADSAASTAAAVERRLARIGERAARVAAETAAERDAVDDAARARYGPAPLDPLAAMHALAAGLPPDAVVVEEAITAGIALRSVYRPDRPKSYVHTVGGGLGWGIGAAVGSSLGDPARPVVAVLGDGSAMFGLQGLWSAARYDTPVTFVVVNNGEYRTLKDTLDGTKSRSTEQDTYLGLDLPGLDWQAAARLFGLASTRVGHTDELRALVAGAGDRTQPLLVEVPVTTHAFTAASGRSSAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGX6</accession>
    <name>A0A011AGX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate (FAA) hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850494.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2314"/>
    <dbReference type="HOGENOM" id="CLU_067056_0_0_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="216"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="392" mass="41213" checksum="7EAC69B721ABE8D4" modified="2014-06-11" version="1">MNWPPTAALPADADAATLVGRVWRPGLGPSVVAVRGGELVDVTGAFPTVRELTESPDPATALADAPGEPLGPLAEILANTPPETRDATRPHLLAPVDLHVVKAAGVTFAASMLERVIEERVRGDAGAAADARADIHALIGTTTPRPGSPEAAKLREVLVAEGRWSQYLEVGLGPDAEIFTKAPVLAAVGTAVDAGVRRDSTWNNPEPEVVIVVSSAGAVVGATLGNDVNLRDVEGRSALLLPQAKDNNASAALGPFLRLFDAGFGLDDVRVATVTLTVDGEDGYHLDGESSMAEISRDPAELAAQLMRSHCYPDGAVLYLGTMFAPTADRHTPGLGFTHDEGDVVTVASPRLGTLTNRIRPADACEPWTFGLADLMRSLRERYVREAPEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH30</accession>
    <name>A0A011AH30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">CryarDRAFT_2416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850587.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2379"/>
    <dbReference type="HOGENOM" id="CLU_050012_2_0_11"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="397" mass="42322" checksum="93D1ED9D2484556F" modified="2014-06-11" version="1">MGLAGRLYRGETNFDFIGTRKRWYIASVVIGVLLIGTIAIRGFNWGIEFSGGTSFVFKQPSGVSLEQVSETIDETGVEVQTGQEAGRGGDAKFVIKTASLSPEKTTEVKNALADTYDLNANDITDNAVSSSWGGQVTDKALIALVVFLVLVAAYLAIRFEAKMAVAALLALLHDLLLTAGIYSIVGFEVTPSTIVGLLTILGFSLYDTVVVFDKVSEDTRGIVGGSRIDYAQAANNAVNETLMRSINTSLISLLPVGGLLFVGAGLLGVGTLKDLALVLFVGLAAGAYSSLFLATPWLVDMKEREPRYRALKERVANKRANAAKATPETTADEDADDLVDDATEVDEDADDDSDREPAAAAAAARTNRNATRPAQQQNRRRAGGNRPGRPSGSRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI25</accession>
    <name>A0A011AI25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-dependent carboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2736"/>
    <dbReference type="HOGENOM" id="CLU_028967_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="28699" checksum="4F2C26D358258485" modified="2014-06-11" version="1">MTVVRTGPRVVLKDTGRSGYAGYGVAPSGPVDRGAYAAANRLVGNPAGAAVFECLLGGLVVRFDGPAVVALTGTDATLLVGVTEVPSGQAVDVAPDVPVEVTTPRHGLRGYLAVAGGIAVPPVLGSRSTDALGGVGPPVPRPGDILPIGAAAGAGAPGREAPDLATPLVATVDLGPRDDWFTGPAIAAFLTAEYTVAPASDSVGVRLSGPPLARSRAGELSSEGVVRGAVQVPPDGQPIVFGADHPLTGGYPVIAVVHPRDTDRLGQARPGRTVRFALATDFLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ61</accession>
    <name>A0A011AJ61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851609.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3157"/>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_11"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="12371" checksum="3B64C1BF12EB1C5B" modified="2014-06-11" version="1">MAATSVPLPLAFTACCSPVTGGALDEDAAAALAKVFKALGDATRVRLVSLIAASPDGEACICDLTAPVGLAQPTVSHHMKLLAEAGLITRTQRGKWAYYRIVPEALAAAARALAPVEATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJD1</accession>
    <name>A0A011AJD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphopantetheine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851714.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_10_0_11"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="85" mass="9163" checksum="CB81717ED27775E6" modified="2014-06-11" version="1">MHEEVRAVLRTVPKLAGVVDTLPVDADLWAAGMDSLTSVHVMVRLEDHFDLQFSEDALTRDTFGSIQAIAAAVSAVVASREGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK05</accession>
    <name>A0A011AK05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3423"/>
    <dbReference type="HOGENOM" id="CLU_027128_6_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458728" evidence="3">
        <location>
            <begin position="30"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="41"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="384" mass="39820" checksum="79887A1CD8460850" modified="2014-06-11" version="1">MLKTRTTRRAMVAAAAVLALTLGACSAPGENSEDEGGGDGPIKLAVVNAQSGQLSSLGKWEHKGVKLAVDEWNAKGGIDGRTIELGLFDDQGDPTIGTNLARKIDSEGYIAMLGTAESAVTIAMAPILRQAEIPNITSGQSPGLTAVKSPFLFLNGPTSTTYDESLAKHIVDQKKITKIAMITNNGGYGKGEHDAFTKALAGRGIKPVDDQVVTTEQKDFSAALTSVRQKNPQLIFLGAEEVESGLIVKQARSLGIRVPFAGAAPQGTPVFLDTAGAANAEGTIVSSPYLSNDISEASKTFAADYQKAFGEEAELHGAKAYDGAQIMLTALKNTKGAGGKELADAIRAVKHQGLLGNFAFDDTGVGIFETSIGTITGGKLVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK34</accession>
    <name>A0A011AK34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3463"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="35310" checksum="9804ACEE87243E77" modified="2014-06-11" version="1">MAPVAERWTQVETIPIEENDMAQTFVTGGSGFIGRKLVTRLLADGHGVKVLVRSAASADVVAALGAQPVRGELTDPDSWRAQVEGSEVLFHLAAETDITADRERQELVTVGGTRAALQAARQAGVARFVHCGSEAALLAGEPLVEVDESAPLRPDSEAAYCATKADAEALVLAANAPGFVTVSIRPRFVWGPESSLVEGLVQAARNGEFAWVEGGRHTTDVTFVDNAVEGLVLGWLRGRPGQAYFVTDQHRVILREFLEENFALYGVDATIPDLDADTAARVIPVPARWFLEQACTLRTDKAVAELGYRAILTQAEGLDAVRNAVIRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK53</accession>
    <name>A0A011AK53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852071.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3484"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="20982" checksum="0153BA3D9A102E6E" modified="2014-06-11" version="1">MARWQPDAHARLEDAALELFAERGFDAVSTAEIAARAGLTKATFFRHFPDKPEVLFWGQDLLAATFRHAIADGAADASPLQLVRAAVLAADPVFDADRHRRAATRQRLIASSATLHERAVLKRAVLARTMTEALEARDVATRTAELAGLAGTATLDAAYAHWAASPTYRAFAGFADREFDLTVRAAAGLTAPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALH3</accession>
    <name>A0A011ALH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxyacid dehydrogenase, FMN-dependent L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852680.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3923"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_11"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="411" mass="44840" checksum="BBB4D09B3DB09001" modified="2014-06-11" version="1">MVRRQVPKPAEIFELLQLKKPQLNGRTRRLDSALTIADLRRIAQRRTPRAAFDYTDGAAEAELSLRRARQAFLDVEFHPSVLADVANVDTSTTVFGGPSAMPFGIAPTGFTRLMHTEGETAGAGAAGAAGIPFTLSTLGTTSIEDVKAANPTGRNWFQLYVMRQREISYGLVERAAAAGFDTLFFTVDTPVAGARLRDKRNGFSIPPQLSLRTVANAIPRPWWWYDFLTTPKLEFASLSSTGGTVGELLDAAMDPTISYEDLKIIRDMWPGKLAVKGVQTLEDAQKLTDYGVDGILLSNHGGRQLDRAPIPFHLLPDVTREVGHHVEISVDTGIMNGADIVACLALGAKFTLIGRAYLYGLMAAGRPGVDKTIDILSTEIIRTMKLLGAHSIEELTPRHVTQLARLAPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALJ4</accession>
    <name>A0A011ALJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852714.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3948"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="28657" checksum="54F36CFC0F297089" modified="2014-06-11" version="1">MGKLDGKVAFITGAARGQGRSHAVTLAKEGADIIAVDLCAPVRSAPYAMATPADLDETVALVEALDRRIVSRVADVRDLAALTAAVQAGVAEFGRLDIILGNAGVCSYGDLATMSVEQFEEMIDIDLTGVWKTVRAGVGAMIDAGHGGSIVLTSSTAGLRNLNAIGHYVAAKHGVTGLAKALANELAPHGIRVNSIHPSNCNTPMLTNDGVAKMFRPDLDHPTFADAGASYGDIHLLDVGWIEPQDVSNLVLFLCSDDARYLTGGAIPVDAGMLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALT1</accession>
    <name>A0A011ALT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4072"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="370"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="511"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="761" mass="81764" checksum="F311192DF60AA1E0" modified="2014-06-11" version="1">MLVPERTGSVLPVRPGAPPRGVRAGSWALTGAAAAGLLVVGFGPEPLRGPVGLAGVLVGLAALGFGTARVARPGDRAPWQHMCVAGLLFLTGIAIRIIVPETAVSPPTPMAMIPNVVVIPGYLMSAYAFAGLLRRRRADEDDPAWVDAVLVGVASALLAWTYLVQPSIERTGLPLIQLANSFFPVIDVVLVVLVAQLALAGGVRAPTLWLLIVGSASLFGGDFLYSVRDGNLADLPAHYVDALYTAAFLLFGAATLHPSMRTLTEPQQIVVRDLSRARTVVIAVVLLIPIGVMTAEPVGGALDRWVRAVLCSLIVLALLFRVVRSNNSRARAEDAIRRRATHDALTDLPNRELLSETIATWGDRAVADGQEISLLFIDLDRFKMINDHWGHRVGDELLCAVAGRLSANLRGTDLVCRTGGDEFVVVLAGPSARTLAEATAGRVLDLFSRPFLLSVGEVVTSASIGVASAVSGAEALELIRDADTAMYEAKATGRNTYARFDTRMRDDVRDRMTLEQELRGALERGELYPTYQPIVDLSTGELDGYETLMRWRHPTLGLISPLRFVPIAEETGLIVDAGAWLLREAATQLATWRAERGPGDRPLHISVNISVRQLRDRELVAIVRDVLDETGLPPDALWLEITESGVMEDLETALATLDELRGLGVTLAVDDFGTGYSSLSYLNRLPVGIVKLDRSFVSEVGEQGANESIVRAVLAMAGALDLKVVAEGVETDVQRDWLRDQGCDLGQGWLYGKPVPASEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFJ9</accession>
    <name>A0A010YFJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.18"/>
    <dbReference type="HOGENOM" id="CLU_3268842_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="41" mass="4536" checksum="0873564F7AA28235" modified="2014-06-11" version="1">MPVLLAPSRLTIGMIRNGFAAAARRFDEWTLEAFNAGTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGF7</accession>
    <name>A0A010YGF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847883.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.338"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_2_11"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="20782" checksum="1182114A4C6D94EB" modified="2014-06-11" version="1">MTSTPLTDRQLWNAAAAGDDNAFGAIFDRHAKAVYNHCFRLTGNWSSADDATSATFLAAWRRRSAVTLVHDSALPWLLTVATNTVRDERRSLRRRLSLLERIPTPAPAPDHADAVAERLDDEQRMAEVLAAARDLPPAEREALALCVWSGVSYADAAEVLGIAEVSVRSRVSRAKSRLARTFSLSGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGS6</accession>
    <name>A0A010YGS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848159.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1812545_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458793" evidence="1">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="15606" checksum="A8D65E879311A834" modified="2014-06-11" version="1">MRQLTVVLVVGLLLTTGCSALRSVPSTETHIVSFELETVRPSTYVDMKASYSLEPLADKKNTAFGASWNNELTFHYPDVNRLTLLGEVRVKDKPLIPPPKAAVELRCRIKVDGVLVAENTGFTVSCTHTMTAGRQQRSTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGT7</accession>
    <name>A0A010YGT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.512"/>
    <dbReference type="HOGENOM" id="CLU_108860_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="13943" checksum="D0E31D9E0F86F5F0" modified="2014-06-11" version="1">MARVGSLPLLATRRAEEDEESMDHVPEDSVLTERQESGLNERELAILAFERQWWQHAGAKEQAIRDEFSLSATRYYQLLNALIDRHEALVHDPMLVKRLRRVRAARQRQRSARRLGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHG2</accession>
    <name>A0A010YHG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.741"/>
    <dbReference type="HOGENOM" id="CLU_020412_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="436"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="663"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="748" mass="81821" checksum="EBB4E056B00E2C8D" modified="2014-06-11" version="1">MARPGQTPRKLASDAVEMAVEAARPTVEFDHHAPELIDDPVRPYAEVRGKCPVAWTESHGGHWVTTRYEDIARIARDDATFSSARRSEDSGLGFVIPEGKASPQYPIELDPPESTIYRDLINPLLSRSAIEKLVPMIAQHVTDVVDAFVEDGHADLVQQLTNPVPTAVTLDWLGFPREDWKRLAGPIHDLFAAQPGSEREMRGGMGLAFMGDRIVEIMDERRAEPENDAVSWLVQQVKPTGEPFSNDEMTSVIFLLIAGGVDTTTALTSSTLVHLSRHPEDRKRLIEDPALLDVATEEFLRAYPPAQAMARTVMRDTEIGGCPVMKGDRVLIPWVAANYDPEAFPEPEKFVLDRDPRGHLTFGIGSHRCPGAHLARAMYREMITQVLERLPDYRIDPVGPTPTESWGSQSGWDHIPVTFTPGPKRETATTKSATGLDVQLLSLAAVEPIADGVVSLRLTGDGELPSWEPGAHLDLILPSGKVRQYSLCGDPADTTSYTVAVLREQDGRGGSVEVHDVLAVGSPIRVRGPKNHFRMVDAERFLFVAGGIGITPISAMVREAETRGADWTLLYGGRTRASMAFATKLQEQYGDRVQLVPQDELGHPDLMAAFAAAKPGTQVYCCGPEGLLKAVENTVGDLDLHVERFTSSGTDRVAPIPADSSEFIVKLARAGHEFRVPADRTLLEAVRDVVPGVPYDCEEGFCGSCETRVLAGRALHRDTILTEAERAESSSMMICVSRCASDRLTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHQ8</accession>
    <name>A0A010YHQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848578.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_9_3_11"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="17389" checksum="47937E223DA7D36B" modified="2014-06-11" version="1">MFTKRFTVVPAAYVLLRRDDDQVLLQLRQNTGYLDGHWALGAAGHVERGESVFEAACREAAEELDVGIDPAALTPLCVMHRTKRSGQAIDERVDFFFECRTWRGEPRRREPKYAADLRWVTLDALPEPVVPHERHVLEKLSDGTLEAVVPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHV3</accession>
    <name>A0A010YHV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848636.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.898"/>
    <dbReference type="HOGENOM" id="CLU_067324_1_0_11"/>
    <dbReference type="OrthoDB" id="1225189at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="26413" checksum="E154622350B8D612" modified="2014-06-11" version="1">MPPPTAEPGTPFDVAQSALRLLCDGPGPLAVSGRAIGHGLPRREIRLTELAAILMHPSASYPARDAVWRLLVTQARTGGPAWVVGATGVALPGLRAIAGRLGRPGDPDVQAEVLAGFLAGLRNLDVSAPRVCPRLCNAAQSTARAALRSARPTAPEVSLEAAGDAAAEAVVGGHPDFVLARAVRAGVLTVADADLIGAIRLDGVPVREYAARLGMTEWAIYKRRTAAEARLIAALNAGDLDDMNAQVIAEATGATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHZ5</accession>
    <name>A0A010YHZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative S-adenosylmethionine-dependent methyltransferase, YraL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.941"/>
    <dbReference type="HOGENOM" id="CLU_044779_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29060" checksum="E471BB98CB494B2C" modified="2014-06-11" version="1">MILAGVPLGNVGDATDRLRDALATADVIAAEDTRRARRLAADLGVEPVGQIVRYDDVTEERHTDGLRDRAVGGATVLLVTDGGMPSVSDPGYRLVVAAIAADVPVSVLPGPSAVTTALALSGLPSARFCFEGFPPREPGKRRSTYAALASEPRTLVFFESPRRIGKSLQDAAAAFGADRPAAVCRELTKTHEEVRRGTLGSLAEWAEGGLLGEITVVVGGAPPPSADDAPDAAELARRVALAEAGGVPRKEAMRAVAHAVGISRSVVYDAVQASKRDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI18</accession>
    <name>A0A010YI18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">CryarDRAFT_0978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.961"/>
    <dbReference type="HOGENOM" id="CLU_062456_2_2_11"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="20628" checksum="DCF0AD2C20554374" modified="2014-06-11" version="1">MADGPWLVVGLGNPGPKYAGNRHNVGQMVVDLLAERIGGRFTKHKSRAEVVEGRLGGHRVVLAKPLSYMNESGGPVAGLRSYYRVPPEQTIVVHDELDIPFDSVRLKRGGGDNGHNGLRSISSSLGTKDYLRVRVGIGRPPGRQDPADFVLRDFSSTERKDLPLLVDNAADAAEALLGADLATVQNTFHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI75</accession>
    <name>A0A010YI75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725661.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="21697" checksum="E6EBCAA064E80E8E" modified="2014-06-11" version="1">MRADAARNVGLLVAAARALVTEAGPDVVLDEVARRAGVANATLYRHFPTRGDLLVAVYAGELTALCDAADLDHASPGDALFTWLEAYVGHVASQRALAEAAPAERRTELFDEWHRRLRETMTQLLERAQRSGEMRADLTPADLVAAAGGIARSSTDADQAHRLLGFFRSGVATNRDAPAPGRAGRSGGEGLDATGLGTGQRGRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIY5</accession>
    <name>A0A010YIY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569821.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1242"/>
    <dbReference type="HOGENOM" id="CLU_010524_0_0_11"/>
    <dbReference type="OrthoDB" id="809897at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="981" mass="105966" checksum="9E2C13CC4C63976E" modified="2014-06-11" version="1">MWTEPALTYRGALSILGKYDRPIFDRLERLVSVSVLGGGLLELVDPKNDGVRLLRGFLDGVHGTLLGVSGYDRLQLIAAAHTTVVVSSFFEALQAQLGPSYDELEFTDAEKVRLATGRVEQPRLDALSQAPVPIPGPRFGFRENLDERLVPYYARLAADCAAFVCGLARAVTLDQADLVRRAVATYEATFVRLAADVPEFGFWLVLGESSETRREVRTWGGELVAATGRRFDVVEELLSRLVTGGAPPSLEVLGALHRSVLARPVLGDPAVDAVATLPTVEQAYIAPSLRVAEADRASSPADPRWWADQRLVSSPELFFADYLTSPSSVSVPLLVLGLPGAGKSMLTQMLAARLPVAGWTAVRVPLRRVRADAPIATQIQEALDLATHGRIGWAQLVEDAAAAGTTRVVVLDGLDELMQASGVSQSRYLYEVAEFQAVEAALGRPVAVVVTSRTVMADRVVIPPGTLVVRLESFSDEQVAQWLSVWNGLNAGSPGFRALSSVPPALAELGRQPLLLLLIALYTADPSAPSLDSGVTTAVLYERLVTHFLRREALKEPRADVERFVAERRWPLTLAAFAMLNRGRTYVTEPELGADLAAFLGTSPEPVDHIVRTVGRFFFVHASVVDATHGLPATYEFLHSTFGEYLVASHLAAQLRLTARRPGPGGPPDSDRLRALLSHVPLVTFPRVLEFFTEAAAEVLPALVADARRTLTPWTPAAYNPSGRDVLDHYAIYTLNLVSLGSDRRVPLADLAPAGTDAVAWWRSLVRQWRAALDDEAWLAVVGTLTVRPGWVLERASSRAHLGTAPANWLARGEARLLGDVRLDALVGAGAAAWRGTVPTDTEAAVVFAGLVEMQLHGVIHPRVVRAAVALDDRLPPPAFDVLLTLVTRVATLLAQGRSERGSVEHGIVLALIDARTVLAQDLRAVARIRDTDTGPSAEAVMAGYALDVRLLPWDEPTDWNELASSVLALARRRIAGRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ30</accession>
    <name>A0A010YJ30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057011_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="24630" checksum="C5C501E1B95A5CBF" modified="2014-06-11" version="1">MLNVPALAPGECQVWWARPLTGDVPGGLAALLDPLEQGRRAAYRRDADRARFTVAASLLRVVGGAHLGLPPAQVAITRTCPDCDRPHGRPALPVAGWECSVSHSGDRVAVAVGRTGPLGVDVEEAASRANAGLREMVLADDERGDDFVTYWVRKEAVLKATGEGLRVGLTEIVVTAPDSGPALVRAHRADLPARATLRTLTPGDGYRACLAALDTPALTVTELDATPLLIAAASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJW8</accession>
    <name>A0A010YJW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="134"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="29281" checksum="7C8FDEE6247D1C13" modified="2014-06-11" version="1">MGWSAVVSVALAVVAVVIAFGVVMASRPATRRLVGVLPAPGRTAQSVIVLVAGAAVAVALINVFLALLDGVRENDDLTRFDRPIVEWVASHRTGWANSLVIALTDIGGKAGLTLLLIAVAIVIAVRLRSWRPVALAAVSGGGGALLVTGIKALVARDRPDPLLRAVTEDGFSFPSGHSASSLVVLCTVAWLVSKAVTSNTIRATIWVAAVPLALAIGLSRIYLGVHYPTDVLAGWVLGATWLITVALAVRLPSSPIVPLIRRRRPAPEPAEPVEADAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKN1</accession>
    <name>A0A010YKN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569952.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1812"/>
    <dbReference type="HOGENOM" id="CLU_028880_0_0_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="35688" checksum="6DFCF0A930097354" modified="2014-06-11" version="1">MSTTVLPPPETSSPASFAEHSPLRRLLSWEGAITALLIFAVLVAGFGVDGFADSFNLANAQLDIVEIAILSLTLTLLVVIGEIDLSIASNLGMCSALMGVLWNAGLSIETIIPLTIVVGAIAGALNGFLVTVVGLPSLAVTIGTLALYRGMAYVLLGDKAVADFPVSYTSWPGKTFADLIPYPTILVIVLAIVVGVILHATPIGRSLYAIGSNKEAARFAGIRVKRITFWLFVASGAFAGLAAVIYTFRFSSARADNANGLELTVVAAVLLGGVSIFGGRGTLPGVLVAVLLVGVLRNALILDDVSTETLMLVTGGLLIFSVLAPNAVTWARERLRLRKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKT3</accession>
    <name>A0A010YKT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849926.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1888"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_11"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="104"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="473" mass="53285" checksum="D1307C14DBD1BAE7" modified="2014-06-11" version="1">MFSQPDELIRFIQDESVRFVDVRFCDLPGVMQHFTIPVESFDTDILEEGLAFDGSSIRGFQQIHESDMLLLPDVSTAFVDPFRVNKTVALNFFIADPFTREAYSRDPRNIAKKAEQYLASSGIADTAYFGAEAEFYIFDSIRFDTNQHSSYYYVDSVEGAWNSGREEEGGNRGYKTNYKGGYFPVPPIDHFADLRDSMVNNLQQVGISVERGHHEVGTAGQAEINYKFSTLLHSADNLMLFKYIIKNTAWAAGKTVTFMPKPLFGDNGSGMHTHQSLWKDGNPLMYDEVGYAGLSDTARWYIGGLLKHAPSLLAFTNPTVNSYRRLVPGYEAPVNLVYSQRNRSACTRIPIVSSPKAKRIEFRVPDPSANPYLAFSAMLMAGLDGIKNKIEPPTPVDKDLYELPPDELAEVSQVPGSLPEVLDRLEVDHDYLLEGGVFTPDLISTWIEYKRANEVDPVRLRPTPHEFALYYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLK2</accession>
    <name>A0A010YLK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dioxygenase of extradiol dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850284.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2168"/>
    <dbReference type="HOGENOM" id="CLU_109157_0_1_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="15267" checksum="ABABF7A96F0F0A11" modified="2014-06-11" version="1">MTDRPAVHLAIPVDDLAAARVFYGQVLGLPEGRSSDHWVDWDLHGHQLVTHLVPGPVTPAGLSEVDGHEVPIPHYGLLLGVEAFHELAARLDGTPFVIEPYLRFPNRPGAQWTMFLRDPAGNALEFKAFLDETQVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN62</accession>
    <name>A0A010YN62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862197.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2715"/>
    <dbReference type="HOGENOM" id="CLU_035117_1_1_11"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="159"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="30086" checksum="35D6AE686A7BBCF2" modified="2014-06-11" version="1">MRVGFVGLGNMGGRVSARITGAGRPVLGFDVRASNVVDAGASPASSVADVTAASDLVLLSLPDSAAVEDVVLGGVLPGARPGQIVVDLSTAAPESTVRMHRRLAERGAAYLDAGVSGGAAAAEKGTLTLMVGGAPDVLEQARPVLELFAATIFHCGPSGSGHTVKLLNNFLNAIALSATAEVMVAGKKAGLDLDVLLAVLNAGSGVNFATLNRFPKIVHGDYLRGGLTNTLMLKDVNLYVELVARLGVASPNSAGPLASFGLARALGYADEISNRVVDAIGDLSGGVRLHTPDEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNS2</accession>
    <name>A0A010YNS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081562_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="215"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="29786" checksum="8C976DB0665CE217" modified="2014-06-11" version="1">MVDDLGERSVVRGALLRLRRTSGVPVAFGGLVAPRGMRLTEFSGTTTGGLRDLLVTAGNGLGGRVLARAGAESVADYASDPRITHEYDRPVLDEGLRAVAAVPAVVGGVALAVLYGGIREPLALGPRVLAAMSAAAADVATELAVRREVERRLRTLETAAITRAARELPSAPEWDEVRAAHAELRAISREVADPGLRRRLLDVSERLTAGDTATEAPGGVRLSERELDVVALVALGCTNAEVARRLEVGAETVKSYLRGAMRKLGTHTRTATVVAARRAGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNY4</accession>
    <name>A0A010YNY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2966"/>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33980" checksum="8EBB48B74D1697DE" modified="2014-06-11" version="1">MHRVAVLVLEGAKPMDVGIPAQVFTTRASMPYEVRVCGVEPGLVAGGDGLSYHVASGLDVLGWADIVFVPGYRFPDREEPPRAVVDALIGAHERGARLAAISTGAFALAATGLLDGRRATTHWHYTRALAAKYPRIRVDENVLFVDEKSVLTSAGAASGLDLCLHVLRGDLGVAASNHAARRLVAAPYRSGGQAQYVPRSVPEPLGEQFAATREWALHHLGEPLTLAALARHAAVSARTFSRRFVEDTGYTPMQWVMRARVDRARELLERSELSVERIAADVGLGTGTNLRLHFQRILGTTPTEYRRTFSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPK1</accession>
    <name>A0A010YPK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138495_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="15888" checksum="FE96FFBBC9EE5EDF" modified="2014-06-11" version="1">MTWETSWRWMRVGLILLAGLDGLVGAWQYFFPRSFFDDFPTVRLDPPYNEHLVADVGGLNLAIVTVLVIAAVVLEYKIVMAGLAGFAVYCGTHFVYHVTNFDGFPVQDAVAVGTGLGIEFVLTIALLFFGYHIRTREPSAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPP2</accession>
    <name>A0A010YPP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851753.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3254"/>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_11"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="27587" checksum="C5B50549907B2407" modified="2014-06-11" version="1">MHHSERQRRILSTARSAGYTDVAKLVADLAVAPETIRRDLRILERRGLLKRTHGGAYPVETARFETSLATRTTRYLGEKRRVASAAIERIGSARTIFIDEGFTPQLIAQELPQDRPLTVVTASLGAAAALAHNTAVSVILLGGRVRGRTLATVDFWGTDMLSGLDIDLAFLGANGISLQHGLTTPDPAVADVKAQVVRASRRRVFIGVHEKFGVCSFCRFAEIPDLEAIVTDAALPGEEAERYMRVGPQVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPS5</accession>
    <name>A0A010YPS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851808.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3292"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_2_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19554" checksum="B994E136169F1B17" modified="2014-06-11" version="1">MRADKTRNQDSVLAAAERLFDTADDPDAVSMDAIAAAAGVGKGTLFRGFGDRLGLVRALYVKRITEELDTLPTGRGLDPSDEAVELLTRMWRFKVRNRGLALALERAGRGSPYRNESYERFHAEITRLLVAAGMGPADFLAHALIAAVRADLVEHLRDQPEADTEAGLRALVHAVFAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQB0</accession>
    <name>A0A010YQB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852138.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2521972_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="84" mass="8456" checksum="D817583D753980D0" modified="2014-06-11" version="1">MPYLVAAVLAVGVLGLLNLLLTLGVVRTLRQVSAVPGPHDAVLPVGSTATDFFPSGASRVIAVVMGTREAAAAVLGELTPVPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQJ7</accession>
    <name>A0A010YQJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Crystall_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034175_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015791">
        <property type="entry name" value="Antimic/Inh_G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015161">
        <property type="entry name" value="Sklp_toxin_b/g_crystallin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09076">
        <property type="entry name" value="Crystall_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458876" description="Crystall_2 domain-containing protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Crystall_2" evidence="2">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13143" checksum="DE3606821F80A716" modified="2014-06-11" version="1">MSRKFHGGRNGMRKPTTVALTIVAMALAVLGWQSPALAVNEVACGTRTDLAKAWDVSGTHCYANAGAMSINLTNVTRLCAGNNVVSWTVWPTATSATQLRQNRWQCNYDVRFVKATRVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRW9</accession>
    <name>A0A010YRW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853063.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4141"/>
    <dbReference type="HOGENOM" id="CLU_111585_2_2_11"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="13565" checksum="D987D75F96F3831F" modified="2014-06-11" version="1">MKYDAFLAQCPSRQLLDRISDKWSTLTLCALSGGPLRYSELARRLDGVSQKMLTQTLRTLERDGLVSRTVEATVPVSVTYELTELGWSLLRTVRGVKSWAENHMDDVFAHREAHDARTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVR4</accession>
    <name>A0A010YVR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847739.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_3_0_11"/>
    <dbReference type="OrthoDB" id="1079953at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="34004" checksum="5E354A861D77D723" modified="2014-06-11" version="1">MNQRRTRFSVAPASEPVTDAAVDTGLRLAVEAAGRAPSMFSTRPLHWRLVSHQLELRVDRDRALTAGDPHGRVLTLECGIALDHALVALAASGYWASVERLPADDVSGLMARILPTGTYEPTASDARLLRAITERRAHQRRVSHTPVPNGTIDRLRRLAEGWGVYLTEVHAESLVEFHVLAARVDEPGQSRRDYPAEAAASAHRLIPLRALCPENRDFLLPGPGHDGSARYLVLWSPRDDSASWLAAGEVTSTILLDGSVAELEVSPMGDVVETPISRTLVHSLLGNRGYAHAVLRIGMRVAEQPTLDLGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWG7</accession>
    <name>A0A010YWG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">CryarDRAFT_0534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848202.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.520"/>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_11"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="542" mass="56750" checksum="6B3D11CB131FE8ED" modified="2014-06-11" version="1">MAKLIAFDEEARRGLERGMNQLADAVRVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPWEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPIALKKGIEAAVAAVSEALGNASKEIETKEQIASTASISAADTSVGEIIAESMDKAGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFATDTERMEAVLDDPYILFVEGKISTVKDLLPLLEKVMQGGKPLAIISEDVEGEALATLIVNKIRGTFKSVAIKAPGFGDRRKAMLNDMAILTGGTVISETIGLKLENTTVDLLGTARKIVVTKDETTIVDGSGDAEQIEGRKNTIRAEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQASSVAFEKLDLSGDEATGANIVKVALEAPLKQIAVNAGLEGGVVAEKVRNLPSGHGLNAATGEYVDLVAAGIIDPTKVTRSALQNAASIAALFLTTNAVIADKPEKAAAPAGDPSGGMGGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZJ2</accession>
    <name>A0A010YZJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1683"/>
    <dbReference type="HOGENOM" id="CLU_100715_4_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="13846" checksum="EBB74A27978B5439" modified="2014-06-11" version="1">MNIQRTAINPSTWSAELGFHQGELVSGHTRTLYVSGQTATSADGKPQHDDDMAAQLALSLDNLAAVLDRAGMTFANLVRLNVYTTDVDLLFAHYGMIPARLGTATTTTMLGVTRLAIPSLLVELEGTAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZP5</accession>
    <name>A0A010YZP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849677.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1728"/>
    <dbReference type="HOGENOM" id="CLU_094601_0_0_11"/>
    <dbReference type="OrthoDB" id="2054078at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="203" mass="22192" checksum="E5D7C4F810601627" modified="2014-06-11" version="1">MIRTLIAAQRVQLADTLTSLPEASWDAPTLCDGWRVREVIAHVAMEFRYPAGRFFWHFALAGFNFHRLNDRRAAADAAALSSAELTASIRDNVHHPWKPPGTGYPTTLTHETVHALDVMVPLGVDWPVPEPTVRAVLDAWDVEHGQKYFGVDLTGVRLCADDLDWSVGDGEPLSGHATDLLLVLAGRKVPAGHLTGASAPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZS8</accession>
    <name>A0A010YZS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849734.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1765"/>
    <dbReference type="HOGENOM" id="CLU_983037_0_0_11"/>
    <dbReference type="OrthoDB" id="1092411at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="30956" checksum="501BE52A3A4AFF29" modified="2014-06-11" version="1">MGWLAVSGGYEVTLDGDTLVCRNAAGKTLRSVPKAIREDPVTVGLRQLTEWLKRHEAQCRADVERWMVRSLPVPAVLLAEVWADDVWAAAARNLVVTTPDGAQVGFLRDAGEKGVGIVDLDGDTVRLDADQLLIPHPVLLDDIDDLREFAADLEFTQSIDQLFREVWARPAEVDPAATRISAYAGGRYAELRHLTARAAQAGFRVRGGYAVCRVFENDSVVEARSWVGAEDPYYETETGDLIFTRPDGVALPLGEVGPVAWSEGHRMAATLYAGRVVEKEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z099</accession>
    <name>A0A010Z099_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849996.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1937"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_11"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="372" mass="40297" checksum="F7EF2626160A38D8" modified="2014-06-11" version="1">MKTLLVTNDFPPRPGGIQTFVHQLAVRQPPGELVVYASRWKGAEEFDAEQPFPVVRHPTSLLVPTPAAARRVVRTAKEHGCETVWYGAAAPLGLLAHTLRKNAGVTRQVAQTHGHEAGWAQLPAARQLLTRIADGVDVITYLGAYTRGKLEGPVRNKAELVHLPPGVDTSMFHPGVDGSAVRERYGLTDRPTIVCVSRLVPRKGQDQLIRALPAIRATIPDAALLLVSGGPYRETLEKLVRERDLENDVKFTGSVPWEELPAHYAAGDVFAMPCRTRRRGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLEGETGYVVGGRDLDALVARTTELLGDAARAQAMGKAGREWVERDWQWDDLAARMTTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z199</accession>
    <name>A0A010Z199_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynureninase</fullName>
            <ecNumber evidence="4">3.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850432.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2281"/>
    <dbReference type="HOGENOM" id="CLU_003433_4_1_11"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="102"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="42569" checksum="89A5020C477595EB" modified="2014-06-11" version="1">MTNATEHDAADPLAPYRDRFVPADVVAYLDGNSLGRPLRVTRDNLVRFVDEVWGERLIRAWGEGWMQTPTDLGDTLGRVTLGAAPGQTVVGDSTTVMLYKLVRAALDARPGRTEIVLDTDNFPTDRYVLEGIAAERGATLRWITADPAAGVTADQVAAVVGPGTAVVVLSHVAYRSGYLADVPGITEVVHDAGALVVWDVCHSVGVVPLQFDAWNVDLAVGCTYKYLNGGPGAPAFAYVATALHGVARQPIQGWMGAADPFAMGPGYQPAAGVRQFVSGTPPVVGMLPMRDMLDLIEEAGLGAVRAKSIALTEFVLAFTDEHLVGKGVRVATPRDAERRGGHVTLDHPSFRELVPQLWKRGVIPDFRMPDGMRIGLSPLSTSFAEVERGLRIVAEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1M9</accession>
    <name>A0A010Z1M9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ORF">CryarDRAFT_2434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850605.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2397"/>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_11"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="41356" checksum="618FCC55A8644BAE" modified="2014-06-11" version="1">MLRWMTAGESHGPALVAMLEGLPAGISVTTTEISEQLARRRLGYGRGARMKFEQDQVEILGGVRHGSTLGSPVAIRIGNTEWPKWEEVMSADPVDEEILAGLARNAPLTRPRPGHADLAGMQKYGFTDARPILERASARETAARVALGTVAQSLLRQALGVEIVSHVVELGSVAVKDGTESPTPADRERIDADPLRCADPDASARMVAEVDAAKADADTLGGIVEVLAYGLPPGLGSHVQWDRKLDSRLAAALVSIQAFKGVEIGDAFTQARSRGSKAHDEIVNTPDGVRRLSGRAGGLEGGITTGEVLRIKGAMKPIATISRALQTVDVTTGEAAKAIAQRSDVCAVPAAAIVAEAMVALVLADATMEKFGGDSVEEIRRNLAGYKAALVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z281</accession>
    <name>A0A010Z281_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850892.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106738_5_0_11"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18533" checksum="035BE9C93B08DF39" modified="2014-06-11" version="1">MESRTLEHLLTLEDIRRLKYRYLRSVDQKAWDDLADTLTVDAVADYGTPAMGDRLLLTGRAAIITFMKENLGPGLISVHAAGQPEIEVNGDTATGRWAFTDLIIAPEYRIVIQGAAFYQDEYARDTDGAWRISRTGYDRTYEATLSLDDLPKFRITANRWATVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2Z6</accession>
    <name>A0A010Z2Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851210.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2855"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="35471" checksum="8EE99F685B727AB8" modified="2014-06-11" version="1">MTAVAADERVASGSALGRVLKRPEVGALVAAVAVFVFFAVATDTFATASGASTWLRSASTIGIMAVAVALLMIGGEFDLSAGAMTGFTGLAVGVMTTQWGLNIWAAMLVSLVLALAVGFLNGLLVMRTGLPSFIVTLGTFFVLQGIDLAAVKAIIGQVAIQGMANVPFYSQPHSVFGSAATVAGGRVYASVFWWILVTAVATWVLLKTRVGNWIFAVGGAQTSARQVGVPVARTKIGLFMTSAGAGWLVGMLLLFTTSTVQSNTGVGQEFIYIICAVVGGCLLTGGYGSAVGAALGALIYGMVNQGIVYAGWDNNWLKAFLGVMLLGAVLLNEAVRRRAERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3E4</accession>
    <name>A0A010Z3E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_44_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="19503" checksum="E769E4B786F8843A" modified="2014-06-11" version="1">MCQTVGMGNREDLLTAAKHCLETKGYTRTTARDVAGAAGVSLAAIGYHYGTKEALLQAALVQALEEWGEELGRTLGESPSGGFAEQWDRVIESFAANRALWSVQFELLAQRDLPPEVRELFAGAHRQARLGLVELFGGAPPGAQAQVGALYQALLGGLAAIWLADPAGTPTGEDLLSAMRAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4P9</accession>
    <name>A0A010Z4P9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2342062_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458077" evidence="1">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="97" mass="10058" checksum="0C24A1F759F10F52" modified="2014-06-11" version="1">MKLVAKLAACVLAAGAAVLPASPAQALPGNCSHGYVTPSKTTSWATCTTGNGRFAALAHCTDGYYYGGPWKYVGTGYSYATCPSDTVINGHNMYTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4Z4</accession>
    <name>A0A010Z4Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3562"/>
    <dbReference type="HOGENOM" id="CLU_071024_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="30135" checksum="F3087E6A5367AF1E" modified="2014-06-11" version="1">MPALTPLPAATPPVTMTIHQLPTGSYSTKANMALRGGSRRETVQFAATAVLVQHPSGDVLIDAGLGRDVEKHQQMLPGYRRVEHRVGSPVVDQLAAAGYDPHRLSGILITHSHWDHVSGVPDLAAPVLITAAEVTYAKKQGADKIFTSFSPGHPLREYTFDGGPYLGFAQSHDLYGDGSIVIVPAAGHTTGSVIVFVALPSGERYAFIGDLTWRLEGIEKNIERLFLMRLFADSDRKQVTVDRERIIAIADLVRVVPAHDERGFAGIPLLVQEAGRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z661</accession>
    <name>A0A010Z661_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3950"/>
    <dbReference type="HOGENOM" id="CLU_000960_34_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="485" mass="49071" checksum="F4487DE21E25428D" modified="2014-06-11" version="1">MSFRTRLALPVACYVVLLVSALQTLVVPVVADIRADLGVSTSAASWVVTANLLAAAVLTPVLGRLGDLYGRRPVMLGVLGVVLAGSVLAAATSSLPLLLAGRVAQAASFGLFPLAIGMLREELPPRRLTGAMALVSGMLSVGAGFGLVVTGLLMRGGGDYHQLFWLATAMAAIGLAGVWLLPRRAGAATGRLDWAGAGLLGLGLVLLILPLEEGNGWGWGSARVIGSLVAAVVVLGAFVLLERRITHPLVSPRMLTYRPIVLANVVGLFLGFAMFAVFLAVSALVQTPPEVAGYGFGASVLAASLVYLLPGTASGVLTAPLGGRLVVRFGAKATLLIAAVLAAAGFGMLAVLHAATWQIVVGALVVNTAVTFGYAALPPLLIANVAPAETGIANGVNSIARSVGMSLGTAFVVTMMTRNPIPGAVPLPREAQFVTTFVVGAVLAAVAAALIAVALPRERAAGLTPAEVAADDVLGAAGLPVPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6I6</accession>
    <name>A0A010Z6I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852985.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4095"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_11"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="24522" checksum="F5EC2396E310D4BB" modified="2014-06-11" version="1">MRAAAVGPAPASMAERAYFALRDRLILLDIRPGEPIDDDELATQLGMGRTPVREALKRLEQDRLVVSFPRRGTFATALDIADLAHISDLRVQLEPLAARRAAERSSGAQRAEILELADLTGQLDVERSDRSEVMRWDLTVHRAIYRAANNPHLEDVLIRYDNLVTRIHCVFLDRLKSTDLNVVAEHVALLHAIAGSDADRADVLARDHVLGFERAIRAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK13</accession>
    <name>A0A010ZK13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847348.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162071_0_0_11"/>
    <dbReference type="OrthoDB" id="2067421at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="90" mass="10057" checksum="42A8049B768D2CAA" modified="2014-06-11" version="1">MSDTEEKSASRNLFDLRWLIAGLFLLYGVVLILLGIFDSDAEVQKADGIRINLWTGIGMFVLGALFTLWSWLRPLRADPAPESLASKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKY0</accession>
    <name>A0A010ZKY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CryarDRAFT_0311</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.296"/>
    <dbReference type="HOGENOM" id="CLU_011263_13_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459134" evidence="13">
        <location>
            <begin position="41"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="14">
        <location>
            <begin position="64"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="436" mass="45242" checksum="4872027BD631E0EF" modified="2014-06-11" version="1">MHHRDTGPRPFLRRARTTMASFLTVVVLFAVAAPVSPAAADTVRDQQWQLSFLDAQAAWRYASGKGVTVAVVDSGVDATHPDLIGQVLPGTDFVDGSTDGRTDVVGHGTAVAAFIAGLNDTNGVVGLAPRAKILPIRVLDPRNEYDSAATIAKAVRWGVDHGADVINLSLGSADTAKVLTDALAYAFSKDVVVIACDGNLSNDRGAKVWHPARERGVVAVSGLARTGGFWSGSLQGPETVLSAPATELTAAGLDHGYWKVQGTSFGAPMVSAAAALVRSRYPDLSAANVVNRLIRTADDKGPAGRDAQYGYGIVDPVGALTEEVSSVSRNPLLTSHAANQGGSAPSATPAPSVPSSDESAVMAPGPAATTTSPTAEPVLASRIDSLRSRALLFGGAIAAMLLLALGTVGIVLVRQPPRTRRKGWDIPPDDHRPPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNS4</accession>
    <name>A0A010ZNS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849168.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_2_0_11"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="15473" checksum="3B5F2FCFE3513F09" modified="2014-06-11" version="1">MPRHTEWCQVRWSDMDAFGHVNNARFLTLFEEARTALILDGGEALSGMLDGCVVIRHEIDYVRPVRYGRGPIRVDCWVTEVRAASYGVGYELFNHAEESAARGLTKLVPVSLPAGRPRRLRPEEREFLEAWREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNW5</accession>
    <name>A0A010ZNW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569869.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1421"/>
    <dbReference type="HOGENOM" id="CLU_064724_2_0_11"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="31267" checksum="7111AD30B1DC4FA1" modified="2014-06-11" version="1">MRCELLRGAIGLSAFTPAVASWLARDPVRHNHLCTVVSQRADGVLPTEPDALWALIRAAPGTPPAWIAAWTPPHLLLVPELDDEAASALVDALLEAGETVPGVTGMAPGPSAVARAWTARTTASARRGMSTRLLVLETLRAPDDVPGRLIRADWTYRPWLIKAVLGFEADTPGDEPEPFTERDAARRVDYFLSGGRAWLWEVRGEPVAMVCFAPPAAAAYRINAVYTPPEHRRRGYAAAATAELSQHLLDIGAAAVLLFTDAANPTSNGVYERIGYRAVAEGETWTFTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNZ8</accession>
    <name>A0A010ZNZ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ORF">CryarDRAFT_1487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849283.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1460"/>
    <dbReference type="HOGENOM" id="CLU_092688_2_0_11"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="13985" checksum="E3C87DC0D2084671" modified="2014-06-11" version="1">MAVSARANELALAAAQAASDKLATDIVVLDVSEQLVITDAFVIASAPNERQVSAIVDSVEERLLGMGAKPVRREGEREGRWVLLDFVDIVVHVQHAEERSFYALERLWKDCPVIPFVDAALADTGNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP62</accession>
    <name>A0A010ZP62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849379.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1522"/>
    <dbReference type="HOGENOM" id="CLU_128798_0_0_11"/>
    <dbReference type="OrthoDB" id="1817677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19474" checksum="6E7FFB715756EF6F" modified="2014-06-11" version="1">MKLLDRLFRRDAPPVTPPLDPADRVVSWATTAEAVAVASVHALWLPPKKGVSDQEWHRLGWHEIHKAVWRDGSLVVTPGVEVEPGVVADGAVRRLRLPDPRDLPVQVRERVERSVAHTEHHALSGGGGVRVVARRVPGHDGLTWQLRFDDPADRSSDAARAEAEVLLDAARATHEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPP9</accession>
    <name>A0A010ZPP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847691.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.207"/>
    <dbReference type="HOGENOM" id="CLU_098254_0_0_11"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="161" mass="17974" checksum="3C2906EC2367DDC8" modified="2014-06-11" version="1">MTHIRTYVEMTSAAELRPGRFAEAVALLPITGQTGLIRDLETRVGEPHGWGAGTRSEEAWAEEFAKTYLQWWAITHHDEPVGLVELADRAPEVEITTFGLLPEAVGRGIGGHALTLAVRQAWLLRPGVTRVWLHTSTQDHPNALPNYQARGFKAYRTEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ95</accession>
    <name>A0A010ZQ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847972.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.391"/>
    <dbReference type="HOGENOM" id="CLU_123281_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="17260" checksum="8BDA443984BBDFDB" modified="2014-06-11" version="1">MTPPPSPPTPTPRLTPTRPGSLALVVLVACVAAWALANRFYGDLPMFTWFPALTLALLAIFELIAARATRARIDRQEGAGPVEPLAVARFAALAKASSLGGALFVGLYAGLLLFLLSERERLAAAADDVPECTGGLIAAVLLVGAALWLERSCRIPDPPDDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQR1</accession>
    <name>A0A010ZQR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter substrate-binding protein, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2073"/>
    <dbReference type="HOGENOM" id="CLU_027128_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458251" evidence="3">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="32"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="41257" checksum="1B1B2827437EDF72" modified="2014-06-11" version="1">MRIRMASLLAGALVASTLAACSSSGGDSETGPIRIGLTVPLTGNYQALGTGDQQGAQIAVEQINADGGIDGRKIELVIKDDKTQPDQSVLAFNAHKNEGAVAVIGSSFSNSALAAIPLAERASMPYLSLAAADQQVDPVRKFAFQIPARSSTYAEQTLKYLQATKITKIALAHDTKSSYAVAGYDAVKEKASQYGVTVVVDRTFDTGTQDFSAVFAPVRTSGAQALFFWATGPPAVIATKQFAASGLSIPLILTGAQGTPLFSKPAGAAADKVVLSTSIGVIGKDLPAGDLKQAVDKLAGDYQKKYGTYPPQFAADGYCGVIVLAEAIRKAGSTDGKKVQAALEKLSLLTPNGRYEYSADDHSGLSTDNIAIARITGGAFVPTTWMTEQLTTNLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQW5</accession>
    <name>A0A010ZQW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1892726_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="13849" checksum="54216F48FE31F33D" modified="2014-06-11" version="1">MTASPTCEESVVTALGWHGTPVDGVRVRDTDLTVVVSGGDGGAPTLAGVLVPVRGSWRQALSIARACLAFAPVALVLPEAPSELCRLECGYADVGIVVAGDVVAPARAHRPVRSTRSTFDRVLSGELDRVLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR31</accession>
    <name>A0A010ZR31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2197"/>
    <dbReference type="HOGENOM" id="CLU_056369_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="88"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="449" mass="48328" checksum="238F4AB0BD6702C3" modified="2014-06-11" version="1">MTASIAGGAPDGARHHPAANLRTRVPKHEGRGPHREVPPETTWSRVEPHLRRAGVTRLADVTGLDRVGLPVYTAVVPRSNDTISVYAGKGPTRLSAKVSAVMEAMERFAAWLPVRPAVVASYAELDAAGRVAVDPRSVCVETTASYRPDGPLSWVTGWDLLAGEPVLVPQDAAVYQRRLHEPPTYRIATTNGLASGNSIEEAVCHALCEVIERDALTLADLVSGRLVQLAGRRGLDATALEERHPVVGTDSLTGRAAEVVAAYERAALRVRLIEITSDLRVPTYVATTEEDLGPGTSRCHSGWGTHPDAEVAIVRALTECAQSRAVDVQAMREDISAPGEEVSRYERHTRRAQVVRRDDWVRRTTEPVSAAARPSYPSGDVAEDIRLMLGRLRDAGLPRVVVVDLSPPEIPVSVVRVLVPGLESWAVDHSKVGARAAAVWNAGLAEVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSF4</accession>
    <name>A0A010ZSF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1198"/>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15686" checksum="E6DD9DB00A22B861" modified="2014-06-11" version="1">MARGDLTNAEWEVLAGLLPPAKPGGRPPRSRRQVIDGIRWRVRTGAPWRDLPERYGPWETAYALFRDWQRDGTWARIVSDLQSRAQARGLITWDVSVDSTVVRAHQHAGGARKGGRIRNNRREGSPQSPTTTVWDGHAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSM7</accession>
    <name>A0A010ZSM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849027.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1268"/>
    <dbReference type="HOGENOM" id="CLU_094585_1_1_11"/>
    <dbReference type="OrthoDB" id="1602136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15111" checksum="03A4E5BCBFDA6E73" modified="2014-06-11" version="1">MTQTARATGELNWLLDDLVDRVPHAQRAVLLSSDGLMIGGSRGLSREDGEHLAAVASGFQSLARGAGRYFGGGAVRQTIIEMEQAFLFVTAAGRGACLAVLGDADADVGLIAYEMAMLVTRVGTYLSTSPRSAATPRPDDRGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT09</accession>
    <name>A0A010ZT09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851264.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="221"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="36480" checksum="EF83BE1535561435" modified="2014-06-11" version="1">MSDWAGVLLTAFLLLANAFFVGAEFALISARRTTIEPRALAGSRAAKTTLRAMENVSLMMAGAQLGITICTLALGAIGEPAVAHLLERPFVAVGVPDDLLHPIAFALALALVVGLHVVVGEMVPKNIALAGPDRSAMLLAPPLVAIVTALKPVIFVLNAMANLILRLVKIQPKDEVSSTFTRDEVADLITESRRAGLLEPAEHTLLTRALTLDERTVRRVALPLASLVTVPRSATLEDVEDVAARTGFSRFPVVSATGVPVGYLHLKDVVIDTVTEGVPHTAPIPADIVRPLPTVDPGATLREGIAALRNSGAHLAQVEVDDGVALVALEDMLEELVGEIHDSAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTP4</accession>
    <name>A0A010ZTP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851621.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3168"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="31949" checksum="59933E50A47F4160" modified="2014-06-11" version="1">MRAAVVREFGGPEVLEVVEVPTPAPGPGEVLVAVAGASVNFADVMVRAGMNVQYGATGAREQFGLGSDVAGTVAAVGTGVTRFAAGHTVVGTQERLDRSLGTQAQYVVLQDWELAPAPAGIDLVELATLGLNATTADQALDALALTHGQWLLVTGAAGAVGLFAIELARLRGLRVVAQAGPGDEKLVRTAGADLFVSRHEDLVPAVRRLVPGGVHGAIDAANLAAGAADAVRHGGAFVSLLNSAPMARRQVRMINLAWHTDAERLAKLAAYAGTGLISLRVAKTYPLEQIRDAHETLAAGGHRGRIVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU46</accession>
    <name>A0A010ZU46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851872.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3325"/>
    <dbReference type="HOGENOM" id="CLU_142134_0_0_11"/>
    <dbReference type="OrthoDB" id="2002590at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_19" evidence="3">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ZnF_CDGSH" evidence="4">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14406" checksum="7D839D63EC73748C" modified="2014-06-11" version="1">MTEPGPKSYQGSDIAVTFDGGRCLHFAECVRGLPEVFDVTARPWISPDNADAAVVADVVERCPSGALQYSRRDGAEEVPPDPTVVTAVESGPILLHGNLVLTEPLQPSHRQNRMALCACGRSAKRPFCDNACRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU73</accession>
    <name>A0A010ZU73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1799"/>
    <dbReference type="HOGENOM" id="CLU_120964_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="113" mass="12347" checksum="52B38E244C4DF450" modified="2014-06-11" version="1">MNPGVKAALTRFRIAAYVVGVGLLVLVLVAMPLKYFGDTPEVSSIVSPIHGFLYMVYLGVTLDLAMRLRWPALKIIGVMLAGTIPFLSFVIERRVHRQAVARLEPRDGVPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUM9</accession>
    <name>A0A010ZUM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1967"/>
    <dbReference type="HOGENOM" id="CLU_054192_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="33455" checksum="363BA5488505943D" modified="2014-06-11" version="1">MDSGNGLSVGIASVPPVTINENVSTFAGLPVREWPADGEPVGGPAAWRISPGLEAERGEFARRLDELIDSTPVEALLVGDWGDCYENPAPIDALVAAAPRLSGLRALFLGEMTFEECEISWIRLGDVAPLFEAFGSLEVLRIRGSEGLRLGTVRHETLRELAFESGGLPAAVVRDVGAGDFPALRHLELWLGTPNYGGDATAEDLAGILSGERLPALRHLGLRNAEIADDVAAALARAPIVPRLTTLDLSLGLLSDTGARALLTGGQLSGLERLDLHHHLVSEEVLGELAAALPGVVLDTEDSQLGERYRYVAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUZ7</accession>
    <name>A0A010ZUZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2093"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="196" mass="21040" checksum="ABE441F4B364880B" modified="2014-06-11" version="1">MASGPGHAQPVNGAARADRGPSGRQLPPAQGEELIRQIYVEHGRALLAYATRLTGDAAAAEDVVQETLVRAWKHGEALSDGSRSVRGWLLTVARNIVTDRARARRARPTEVAENPATPPMERDHSDGVVDTMVVLDGLGTLSAEHRRVLIEVYYRGRTTAEAAEVLGVPAGTVKSRTYYALRALRSALGDVVGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV74</accession>
    <name>A0A010ZV74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850289.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2175"/>
    <dbReference type="HOGENOM" id="CLU_001305_0_4_11"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1300" mass="139454" checksum="B978EBDB979C2BFD" modified="2014-06-11" version="1">MADDIDFRAVCDELAVRTNGYRNDGEAQPLLAPEAAAAAEMILARRAEAGDFELVVVAVVAWFHWQRSLALPDGEGDPDWGIARDLFAELAPLLPDFVPDEFRGVGRVINSRPQLALLDRALRRLPNAIDAGGSSLDEVIDLLARGTPELTSDSPGYPAVMSNYGVALRTRFEQSGSTADLDEAIRVSRDAANRASDDHPDRAALHANLALALLGRFTIAEDRADLDEAIGAQDQAVDGSSGDRHRLVLAQLLSTRFRLLGLRDDIDRAVRVARDAVSGAPSSSSWAVLGQTLADRFDISNDLVDLDEGLRLLREAARAMGSDDPDLAGVLTSRVDALRTRFERCGRSEDLDEAVRIAGEAVDASASDDARRGASLSCLARVLLRRFEVRGLSDDLDTAVECGRAAVTITPFASVNRAPRLSTLAASLLSRYDQSGAGDDLAAALEAAREALDACPPDSPHRADYLSELAIAWQASHEQTGLASDLDEAVRLGRLSVLEDVGGGAEGARRRSNLATILLSRFMSSGSLDDLDRTIELAELASRACVPGNPARGTYLNNWASGLLLRAIGTGARADLDEAVRVAREAVAATADGHVEHAKHWATLGAALQHQFRRTDNFGDLEDALAACRQAADSVGSRRPDRIRYWSNLAAALRARFDHTEDRRDIDEAIALGRRCLDTFVPGGLGTIALGANLASALLTRYREFGDERDVDHAVQAARQAADVGPPDHPDRGIALLNLGNALHTRREAGDREAAYEAWRAAAALRATATQYRFSAAIAWGLAAAEDGSWTLAADGYGEAVGLLPLLAWQGARRTDAEESLTRAAGMVSDAASCAVAAGDPDRALEIIEAGRGVLWSHQLDSRTDLGEVRAVAPELAAELADVRAALDELGDDLVTLLPAVAGDAGRRAALSRRWDELVARVRELPGLAGFLRAPSAEQLRQRTVGGTAAIPIVSRWRCDALLVTPDAVKALPLPGLTKETVTEHIDDYLLAIQRFESGPRSPRDRTMFEAAISRSLEWLWDAIAEPILSAAGLGRHVDGSDWPRVWWCPTGPLSLLPIHAAGRHRDGVAGYAVLDCAISSYTPTLRILDPDLRENVLADSDGTARRLLVVGMPSTPGASELPTFAVERDLLTRLMPGRTTVLEGPAATRSAVNSLLDGHRWAHFTCHGTQDLAQPGRGGLVLHDGRLTVTEMRRSAAQAGEVVVLAACKTATGGLRLSDEAITLAAAFRYHGWRHVVGTLWSVWDVSTAMVTTDMWTRLQTVNEGSEDTAGALHHAVRALREKQAGNPSLWALIAHYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV90</accession>
    <name>A0A010ZV90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852533.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709637_0_0_11"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="43673" checksum="7E3031D929529FFA" modified="2014-06-11" version="1">MAEAADTLRYDVVILSANFHIGRFQTGAGYRCLELALSLHDLGTRVAIVAPGATDFDDLPVDVLDRETLTPDDILACARVFLFCLREDPDLIEFLAGHDRSLIYDSYLSPVEQLTFASVVRMEDDQQKENYFHGVIRTHTRFNELACSYLVGEPQEKLLKLGELINTFQVRPADHVSLGDTILPLPVVSYHRRSLPTGSLEPTGDTFLWNGGLYNHYDGVDLLIDAVTALRESGRDVRFRFLYPGEHTLAHQRIVRRKTDEHLPYVELGAPPDFSAKAAILASCRALVLTYGSVLQMHLFLSMRMREMLVYEKPMIVSRPGAIGAFVEEHGVGLVVDNTVGAVRDAMERLVVDASLYDALRDNIRRLKKRYDMANFVPPIARLITVANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW54</accession>
    <name>A0A010ZW54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavoprotein involved in K+ transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4075"/>
    <dbReference type="HOGENOM" id="CLU_006909_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36524" checksum="407C7B6D10AF13E8" modified="2014-06-11" version="1">MVVVGGGQAGLSAAYHLRRRGIDFVVLDAEAAPGGAWQHRWESLRMATVNGIFDLPGFPKSPIEPDEPSRTAVPRYFAAFEREFALPIRRPVTVTAVRDSGATLLVETDHGAWEADALINATGTWTNPVLPRYPGHFDGIQRHTSGYVRAEDFAGLRVAVVGGGISALQQLEEISRFATTFWYTRREPVFRSGEFDPEAGRRTIAAVTADVEAGEPSGSVVSYTGLTWTSYARAAEERGVLERRPMFTALEPGGVREADGGFTPVDAILWATGFRAALAHLDPLHLRNERGGITMTGTQVAGEPRVHLIGFGPSQSTVGANRAGRDAARALAQYLTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWZ6</accession>
    <name>A0A010ZWZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851157.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078522_1_1_11"/>
    <dbReference type="OrthoDB" id="1436862at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="24628" checksum="AF662F5C9CFBF35D" modified="2014-06-11" version="1">MTMTAPRIRRAAAGWWLGLSALAIAVYAPLPYLTTSLAELAADDAGLAANYVDRPAVVQVFFYLHVVSGGTALVLSPLQLSARVRHRVPAVHRVVGRVTFAAIAVGGVAGAVLAPFNQAGPVGTAGFGLLALGWLACAGAAYAAIRRRDVAAHRRWAIRTFALTYAGVMLRLWLGVLIVAGSSLAGLDEGDAFALAYPAAAFLCWVPNLLLAEWLLRRRRPTGHRRPLNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX02</accession>
    <name>A0A010ZX02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851168.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2824"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="31690" checksum="C5D3973E0D3DF86B" modified="2014-06-11" version="1">MTDAVSVSGLIKNFGPTRALNGLDLAVRTGEVHGFLGPNGAGKTTTIRILLGLARSDGGTARLLGGDPWKDATTLHRRLAYVPGDVTLWPNLSGGEIVDLLGRLRGGVNQKRRTELLERFQLDPRKKGRAYSKGNRQKVALVAAFASEADLLILDEPTSGLDPLMEEVFRASVAEFVATEGRTVLLSSHILSEVEALADRVTIIRDGRTVESGTLAELRHLSRTSIRAELAGPAHLDRVHDLVVRGDRVTFTVENADLDHVMRQLAGIGIRSLESRPPTLEELFLSHYEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX44</accession>
    <name>A0A010ZX44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851222.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2864"/>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18246" checksum="607DFA8B308ED556" modified="2014-06-11" version="1">MESFDSYVTADGAALLRFAHALTGDHHLAEDLVQEALVRTHRRWNRVDQPGAYVRKAVVRQFLSWRRRRSSGEIPAPEFGRDEPSSADHADVLADQDALAALLATLPRQQRAVLFLRFFEDLDDAAIADVLGCSAVTVRGYASRGLARLRESAPETFVRNGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY20</accession>
    <name>A0A010ZY20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863117.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3210"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="42580" checksum="63F9688B8A0ABBA5" modified="2014-06-11" version="1">MTGQRRVLVVGLGISGMATAIRLHEAGWTPVVVERSPERRTGGYFVGLFPVGKAAAARLGVLAHMHLRTPPEHHTWTVDRAGRRHHSAGFLDQPGNPEGVMRGDIEEALRKRIEGRIEVRFATVPVAVQQTAEAARVTLLDTGGDRTYEEDYDLVVGADGLRSTVRRLVFGPDEKFMRSMHAIVCAFSLGHQVPGYPDSDQVILAQPGRSLWIFPFRDRTPTALFAYRTRDVDAEFRNDAITTLTSRFAGLDGGGMVAYALDQLRRQPDRLFDSVHQVRMPRWHDGRVVLLGDSAWCLTLYSGMGASAGMIGGVALGDALAAHPDDLPAAFTAWEKRMRPLVRKHQLLAHLKAQFFVPSNPFLAWVRGKVVAVVARRLTAAQRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY27</accession>
    <name>A0A010ZY27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3216"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="31555" checksum="AD418FAA0A075622" modified="2014-06-11" version="1">MAMRAGPAVSRRAALRGPWGLRVAGGPGLGFHVVLQGSAWLVPPDAANPTELTTGDVVLVRNGSGYGLADHPGSPLPDVAVLELSGDEDLAVIGTDGEPSTVVLCGSFALRHNRPHPLIAGLPEAVHLPARTGVDQRLRSVVDLLGAELDGDAPGTSAAIPALLDLLLLYTVRTWYDRQADRGVGGWAAALRDPAISRALFHLQRAPERSWTVADLASVASLSRPVFARRFTDLVGQPPLTYLTWWRMTLAGRMLHADDSTLSVVAARVGYASEFAFSKAFRRAFGVSPGTYRRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ43</accession>
    <name>A0A010ZZ43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570546.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_1_0_11"/>
    <dbReference type="OrthoDB" id="1079953at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34976" checksum="F5E28D0722A28D10" modified="2014-06-11" version="1">MSDRAAIDQLTEATLAALRAPSVLNTQPWRWTFLGDTAELRLDADRRLGALDPDGRLLLLSCGAALDHAVAALRAGGYAGSVERLPDDTRPELVARLRLGARCVADPRNHEAIYRRQTERRPFAEKPPAAADLDALRAAAGRHDARLRFLTPDELTSFADIAEVADVVEHAEPSLLRDLRTWTTRPADRRDGLPGRTIVPDTWRTVPTRTFRREHEQLGSGTDGGTAYGVLLTERDDRRSWLAAGEALSDVWLTLTGHRLVASPISEVVEVSSARRALRTLLGGSDHPAIALRIGVPADTAAPPRTVRRPNSDALGFPGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZL0</accession>
    <name>A0A010ZZL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the darcynin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852596.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3829"/>
    <dbReference type="HOGENOM" id="CLU_165974_0_0_11"/>
    <dbReference type="OrthoDB" id="1808462at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031409">
        <property type="entry name" value="Darcynin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17074">
        <property type="entry name" value="Darcynin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13900" checksum="95B2CE27A6E779BF" modified="2014-06-11" version="1">MSTAPTESPVTAFMLVKTTPEWLAMTVAERVRAFTTDVVPVIEARTRGVRSRFYDTEFYSARVTDIWVWEADDHDAYRLLIDALRETPFWDRYFEVVELLVGVENGYARTYDLPPAATLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZN6</accession>
    <name>A0A010ZZN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640938_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="161" mass="17433" checksum="4B078956A6622FCB" modified="2014-06-11" version="1">MLWGATSATSATAYVRDQSSSGAAATQGRRPAPRPSPSLSGWLRIRTIVDRFGPWSGHGREEVDQAFRTDQFRRSAEAVVRAPHHGSPAPGGPPRADGTDDIYTGLAAAGLANFHGRPEYWATAEQRYATVDRASLTAAQLPAYQVLETLVVEHRLRRGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A061</accession>
    <name>A0A011A061_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852886.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4043"/>
    <dbReference type="HOGENOM" id="CLU_009942_3_0_11"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="39"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="481" mass="50527" checksum="147A410839ADA52F" modified="2014-06-11" version="1">MSVLLRGGRLGLGGAASDVRIDDGTVTAVGPAGSLDATEVVSLGDATVLPGLVDGHVHVEQWVRHRRSVDLSAATGPAEAARALRATAPAPGQWLSGRDIVPALWDTPAHKRFLDGELGDVPVVVRSIDLHTTWFNSAALALVGLPDHPTGVLRETESIEANHRLSELTPAAEVDGWIAEALAELPSLGLTGLIDLEFSDNLAAWPRRVAAHGAPPVRVHAGIWTPWLDAAIAAGRRTGEVVEGTSGRVRVGPYKIVSDGSLNTRTAWCADPYPDDSHGLCLVPADELEALMSRAWAAGLVPAIHAIGDRANTAVLDVFARIGCTGRIEHAQLVALDDVPRFAELGVVASVQPQHAVTDRDVADRLWAGRTDRAFAYRTLHDAGARLELGSDAPVSPLDPWQAIADAVHRSDDGRPAWHPEQALPLDVAITAACAGRASVEVGAVADLTVVAGDPSAASEESLRGTIVLATLVGGDFTYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0D6</accession>
    <name>A0A011A0D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, histidine kinase/DNA gyrase B/HSP90-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853044.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021898_2_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="573" mass="60486" checksum="EB1803B77BEA51A7" modified="2014-06-11" version="1">MKPRAAPLLVGPLAGLLAFVCGLPYWREHVPAALMTCLGCAGFAAAGGLLAGSADGRRRSGTLLVTGAFCVALAWVVTWNSGIWPLVSFLAQGSAYVLSGAAVLLYPGGRLTGRAERAWVVCAVVVLIGGQVVVGLVSRPEWNGLHPDVVWPNVASQRRVFDLTVEIVIVAQLLLVVWYLVVLVRRARRLSELERSAMLPLLLATGFFGVGAAVLTTGSDAWTELDALLSFYVVVNLLAMAVPLAVLSGALRERWREVDAPHRVVRMTSSTSSVGSVRDALAAALRDPRLRLLFWVPAERSYVDRWGRLVGVPRAAAGRWWAEVRVEEGQPLALVELDEGLRGRAGVVEAVLRAGSPALLTAQLQAVVTAQLELVLAAQARVEERGRAERCRLEADLREGAQRRLVGLVSRLEGLEGLPEPVGSVVVSCRSEVVGAIAELEALARGLHPSVLRAEGLGVALGEVAERLGLVVQLAVEVGRASEAAEATVYFALCEGLTNVAKYAPGARVRIEVTEAGGWVHGVVADDGPGGARVIPGGGLAGIDARVRALHGRTLVESEAGAGTRLRVSLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAQ0</accession>
    <name>A0A011AAQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.113"/>
    <dbReference type="HOGENOM" id="CLU_104649_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="26748" checksum="D1CC64700DBFDBF7" modified="2014-06-11" version="1">MESPPNPAAALDSRPVPVSAAAATTGPTPTRALRERVVGATAIALAASVAIQNAVVLWAGAPSYADPINEVLAFHAEHRVAVAIAVGLEALNLPLLLGFLTGLHGLVERRGRAGTDWSRLAVAAGATLSAVFAVYAVLWNGVVLSAGELAAPSPEFELTWQLHAAAFALALPALGTTFIGAALAAHASRLTPPWQRLLAVAGGGLLLIAGAASLAIADGSALLFVGMPGYAAWLVWLLATGTRLVRARTADGPDDAPTSDKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAY6</accession>
    <name>A0A011AAY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847669.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.196"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="36187" checksum="46D14C0998A3BAA7" modified="2014-06-11" version="1">MLRYVVRRLVGVIPTLFVLSFLLYVWLRSLPGGPATALLGDKATPEKIASLNHTLGLDQPIWVQYAKFVGRVFTGDFGSSLASSRPVGAELADALPATIELSVAALLFAVLLGIPLGYLSAKLRGGFFDNATVIATLIGVAVPVFFLGYMLKSWFAVDLGWLPPSGRVTAGLDQTKITGFLILDGILTREWDVVWDSIKHLILPAITLGTIPLAVIVRITRASVLDVLNEDYVRTAEAKGLRSRTIRNRHVLRNGLLPVSTTIGLQAGLLLAGAVLTEKVFVWGGIGSLLAEGIEKRDYPRLQALILVAALTYVLVNLLVDLSYALIDPRVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABD9</accession>
    <name>A0A011ABD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847876.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303204_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="20748" checksum="7BE4134D87073ABC" modified="2014-06-11" version="1">MSTFTSPRVPVVPLALLAREAGPRLWRGLPVLVVASLPMAVAVAVTAVFTLGGGVLLAPAVAALTIGPAFQLLTALAGGTVAVRAVPGIAVRAFGPGVVRALPVAGVATLACAGLVARAAGPIFAASLAVNLVVLGAALLIAPFAYACGGWRRGAGLTAASPALVLALLTLVALASGVAKLVGPPFLLLLPAVIAVATATQVHLLTKEFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABU6</accession>
    <name>A0A011ABU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848210.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830651_0_0_11"/>
    <dbReference type="OrthoDB" id="1863246at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="344" mass="38863" checksum="981A60279070517C" modified="2014-06-11" version="1">MSVDAHSVPSPVEPNIVRASHLPEENEELIQLTGEVVSARKLHYVGHFTRGFFDFSIDVLADVAGALPSERDVERQREWCRWHGRQMNFLADRLDRQLQTIRSGRLIRTVLEADNQSVHHYQIRTGQYFVGYAFDSPGLQTADRLMADLTNEVRARYRLGSQNPGGYLTQGEGDWILSEFGNSPHVEGFIDESTTQSLVREFSREAVDPQRLHYAAYYDGGAFQGAVDVFSAPQLKLFFDQISRKDRRIRYREIGSRLDAMVRSLEQSMYPVTAGALNRLVLDVEEGALFYNKISTHYPGSYVIGVTVDKSRVADADARVQELSEQIALRLPESSSEDSAGQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC76</accession>
    <name>A0A011AC76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848409.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.673"/>
    <dbReference type="HOGENOM" id="CLU_009834_3_2_11"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="23305" checksum="8A65FD986203715F" modified="2014-06-11" version="1">MPTLQKDGEVFVLDLGDTENRFHPDWLAEVHTALDEVEAAAGPKALVTTATGKFFSNGLDLDWLGTHADELSEYISAVQALLARYLAFPAPTVAAVQGHNFGGGAMLALAHDFRVMRADRGYFCLPEVDLGMPFTAGMTALVRSRLEKQTAHEAMTTGRRYGGVDAAAARIVDAVADEGEVLATALTIARPLTGKPAGAVGTIKAGIYAEVLTALRQPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC81</accession>
    <name>A0A011AC81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848416.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.678"/>
    <dbReference type="HOGENOM" id="CLU_039483_5_0_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27905" checksum="E5052CEEC399E2DB" modified="2014-06-11" version="1">MTTYIGERRTPRLGGLNPTYLGLEIRRTLRNRRTLFFILIMPAVFFLLFGLPQKGQSLDNGQPVTAYIMISLAVYGAMVATTSGGAMVAVERAQGWSRQLRLTPLRPAAYIATKVLSALVLGLAAVLVEFIVGAAAGVRMPVHMWLLAGLVAWVGSLVFAAFGLFIGYLVPAENVMQFLGPILAILAMFGGLFVPLEVLPHAFQEIAKWTPVYGIGTIARSPLTGDTVTLTEVANVVAWTLLFGLGAARLFRRDTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEA2</accession>
    <name>A0A011AEA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">CryarDRAFT_1439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849216.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1413"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="24432" checksum="2FC78E98361795D0" modified="2014-06-11" version="1">MSDLSFPGSGLYNRETAPQGRYVLPSFVERTSYGIKEMNPYNKLFEERIIFLGVQIDDASANDVMAQLLCLESMDPDRDIWIYINSPGGSFTALTAIYDTMRFVRCDIQTVCMGQAASAAAVLLAAGTPGKRLALPNARVLIHQPYSEGGGQGSDIEIQAREILRMRTQLEQMLSSHSGQPIEKVRKDIERDKILTADEAKEYGLIDQVLESRKKVPVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEB1</accession>
    <name>A0A011AEB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="14" type="ORF">CryarDRAFT_1449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849230.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1423"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_11"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="30"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="448"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="612"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="13">
        <location>
            <begin position="809"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="807"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="532"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="876" mass="97461" checksum="B2FA7FAE425E8B8A" modified="2014-06-11" version="1">MTTHPDTQAPPTPSTELSTKYTPADVEGPLYERWVAAGYFTPDATSDKPPFSVVIPPPNVTGVLHIGHALDHTLIDTLTRRRRMQGYEVLWLPGMDHAGIATQNVVERELAKNEGKSRHDLGRDEFVKRVWQWKEESGGKIAGQMRRLGDGVDWTRDRFTMDEGLSKSVQTIFKKLYDDGLIYRAERIINWCARCHTALSDIEVEHSDDEGELVSIRYGDGENAIVVATTRAETMLGDTAVAVHPDDERYQHLIGTEVQLPLTNRRIPIVADEHVDPSFGTGAVKVTPAHDPNDFEIGQRHGLPNLTIMDEKAVITAHGPFEGLDRFEARPAVVAALREEGRIVAEKRPYVHAVGHCSRCDTVVEPRLSLQWFVKVETLAAAAGDAVRDGRVSIHPPELSKRYFDWVDNMHDWCISRQLWWGHRIPVWYGPDGEMVCVGPDEQPPGPEWTQDTDVLDTWFSSGLWPFSTLGWPDETPDLAKFYPTSVLVTGYDILFFWVARMMLLGLYAMDGEQPFDVVALHGLVRDKYGKKMSKSRGNTVDPLDWMDAYGSDALRFMLARGANPGSDQASSEEWVAGARNFCNKLWNATRFALLNGADAGAELPSELSPADRWILSRLHTVLAEVDDLYERFEFAKLTDLLYHFAWDEVCDWYVELAKPELAAGGVRADTTRAVLGHVLDRLLRVLHPVTPFVTEALWTALTGRESVVIAEWPQAEPGRRDPAAEAEIEALQRVVTEVRRFRSDQGLRPTQRVPARLDGLDALGVAAHETLIRSLSRLDPAGDDFTATGTVQVGAELTVSFDTSGTIDVAAERRRLEKDLAAAEKERAQNSGKLGNEAFLAKAPDAVVAKVRERLTAAEADLARLETQLAALPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEG3</accession>
    <name>A0A011AEG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1473"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="4">
        <location>
            <begin position="219"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="615" mass="61585" checksum="7883BE18B3A7B42D" modified="2014-06-11" version="1">MTGTRPIPTLPGDPAGSGATSSAMAPADAADSRTAASGLGSAGALGSAASTLGSAGQLGSAASPLGSAGQLGSAGLVGAAGLAATGDQSGPPAAATGHAGAHGPADVGHSGGPSGSGDPSGSGGPSGSGGPSGSGDPSGSGDPSGSGDPSGSGDPSGSGDPSGPHPTEPFNTPGPGPGGLTAPTPTPTENQRPRTAWQALTRPPKNFLLSSWPWRSLIYLASGSVFGLAVAIGLVVVAMTGAVLSLFAIGLAVLALLPLVGLIIAPIERRRLRLVDAEPIGNPHRPPPGPGPWAWFKHRYREAATWRELAATILLSVLGIADMVGLSVAVTSVGLLLGAPVVVAVDNSAEGAIMFGGWHIESVAESLPLVPIGALLAVLIAYFVTAWAAGRAQLTRILLAPREAEQGERVVALTRSRARLVDAFQAERRRIERDLHDGAQQRLVALTVELGLARLDLPAGSDVSRRVGHAHEQAKLALAELRELIRGIHPQVLTDRGLAPAITDVAGRTAVPVKVDVKVPRRLASEIEAAAYFVVTEALANVDRHSRATSAEVRGSIADGRLSVEVIDDGVGGANPTAGSGLVGLADRVAVVDGVLTLVSPVGGPTLLRVEIPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF62</accession>
    <name>A0A011AF62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dinB</name>
        <name evidence="5" type="ORF">CryarDRAFT_1758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849673.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1725"/>
    <dbReference type="HOGENOM" id="CLU_012348_1_0_11"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="41783" checksum="3866A26E938C5EA3" modified="2014-06-11" version="1">MSSEASILHADLDAFYASVEQRDDPRLRGRPVIVGGGVVLAASYEAKACGVRTAMGGRMARALCPQAIVVPPRMSAYSEASRAVFEVFRDTTPLVEGLSIDEAFLDVGGLRKVSGSPADIAARLRVAVRERVGLAITVGVARTKFLAKVASGVAKPDGLLVVESGTELAFLHELPVERLWGVGTVTSAKLRARRIVTVGQVARLGEAYLVSVLGQHAGRHLHALAHNRDPRPVVVGRRRRSMGAQRALGRGPHGTPDLEAALAGLVDRVGRRMRKASRSGRTVTLRLRFDDYTRATRSHTLTRPTSATAVLLGAARDLLAAALPLITERGITLIGVAVGNLDSQGEQLLLPLEGPDDGGLDSALDAVRERFGSSAVTRATLLGRGEGVAVPLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFS6</accession>
    <name>A0A011AFS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-forming long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861540.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1940"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="595" mass="63379" checksum="BC7BC5C2BA167A0E" modified="2014-06-11" version="1">MREFAQPAVYTVPDGANLTDPVWSAAEEVPDKVTFRRPSGGGWTDVTAATFRDEVVGVAKGLIASGIQPGDRIGLMARTRYEWTLVDYAIWAAGAVTVPIYETSSAEQVQWILGDSGAVGVFVESSDHQSQVEAVRGSLPSLRQVWQIDASAVELLTSGGASVPSADVDERRAALGPADTATIIYTSGTTGRPKGCVLTHKNLLFEVGNALPMLPSMFNEGASTLLFLPLAHAFARLIQLGAVQSRATLGHAPDIKNLMNDLQTFRPTFVLAVPRVFEKVYNGAKQKAHKEGKGAIFDRADRVAVAYSEALDSGGPGLLLRAQHAVFDKLVYAKLRAALGGSCTHAISGGAPLGPRLAHFFRGIGLWVSEGYGLTETSPATAANVDDAVKLGTVGRPLPGMTVRIADDGEVLIAGDHVFSEYWHNPDATAEALKNGFFHTGDLGTLDDEGFLTITGRKKELIVTAAGKNVAPAVLEDRIRAHALVSQAMVVGDGKPFIGAVVTVDPDAFGPWKDKQGKPADATVGDLAEDPELRAEIQAAVDDANQAVSRAEQVKVFRILPRDFTEETGELTPSMKLKRSVVEKEYADEIAAIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG92</accession>
    <name>A0A011AG92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3327023_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="38" mass="4493" checksum="11C29CF9BE061C65" modified="2014-06-11" version="1">MPQPTGGTSWLEGISAFLVLVFFAASWWRARRRRNRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGZ1</accession>
    <name>A0A011AGZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570042.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2319"/>
    <dbReference type="HOGENOM" id="CLU_045683_1_0_11"/>
    <dbReference type="OrthoDB" id="988124at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459485" evidence="2">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="34674" checksum="C4738E382FD145F5" modified="2014-06-11" version="1">MKRTPRVLAAFAAMTLLATTACGATADRDGAGGTSGKPVSGLRILVPNSPGGGYDTTARTLAKVMEDSRIAVGVEVFNLSGAGGVVGLQRIVNEKGNGDLVMQMGLGVVGSSYTQKSPAKLTETTPIAKLIEESGAIVVPKNSPYRTIDDLVAAWKANPKKIAVGGGSSPGGPDHLLPMQLAKAVGIDPRQVNYVSYDGGGELLPALLGSKIAFGASGVGEFLDQIEAGQVRVLAVTSESRLDMVKDAPTLKESGIDLVFTNWRGIVAPPGISDADKQRWIDVLTRMHGTDAWKAELAKHGWTDAFATGTEFATFLTEQDKAVADILTSLGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH40</accession>
    <name>A0A011AH40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850600.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132014_2_1_11"/>
    <dbReference type="OrthoDB" id="2047474at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="14566" checksum="369A1F0913951461" modified="2014-06-11" version="1">MSLGGIAAIIAAVAFVLLVGALAVPLIKLGRTVDAATKAITDITEQAVPILASAHVTVEGVNQTLGGVNHQLDKVDTLTDHVGAVTGSIAQVTTLFGATVSGPLVKAAAFSYGVRSALRARKATEVEREIRDELKKRRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH47</accession>
    <name>A0A011AH47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="12" type="ORF">CryarDRAFT_2437</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2400"/>
    <dbReference type="HOGENOM" id="CLU_090968_2_1_11"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="15459" checksum="067CD7C0E3A959AF" modified="2014-06-11" version="1">MTRVYVLNGPNIGRLGTREPEIYGADTHDDLVALCVRTGEELGLDVVVRQTDAEHEMLGWLHAAADERAPVVLNPGAWTHYNIAVRDACAMLVAPLIEVHISNVHKREEFRHHSVISPVATGAIIGLGLTGYTLALRHLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHJ3</accession>
    <name>A0A011AHJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570093.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="22655" checksum="DE32600E1B4E4314" modified="2014-06-11" version="1">MTRTTRGRPRNPAVEQRIAAAALTIYGDHGWAGFNFESVARAADVSRDSLYRRWNDRRGLLVDAIGRVPPAPAPLEGLSLRDALLRAALSSLERYLAPGGHALIRLYVEAPQDPELLDLFHREVITPAVLAARQLVRDAIAAGRLPADASPTAIIDSVFGAVLLHVLVTPMELRPRMIEQAQSYVTDVVDMTLRGAYYREPEVSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHQ7</accession>
    <name>A0A011AHQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate carboligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850917.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2634"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_11"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="389"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="564" mass="61493" checksum="C54A1AEAB49FBF48" modified="2014-06-11" version="1">MPTVPAMQAVVEILESEGVDTVFGCPGAAILPLYAALQNHGGIEHLIVRHEEGATHMADGWARTTGNVGVAIGTSGPAGTNMITGLYTAQADSIPILCFTGQAVSSKLHQEAFQAVDIVEIAKPVTKWAVQVKEAAQVPWIVRKAFQVAREGRPGPVLVDLPLDVQKELIEWDATIDAPLPVTPVVPHGPRVERALDLLLSAQRPLILAGGGVILADASAELRELAEYLQVPVQVTLMGKGALDDDHGLHAGMTGIQTSQRYGNASFLESDLVLAVGARFGDRHTGALDVYRGDRVFIHVDVEPTQIGKVFGPDLGVVSDARLFLRALLEAARARHAKRQPNGWVTRVQHLRRSLTRREDFDDVPVKAPRVYREINEAFGPDTYFVTAIGLYQIWSGQHQKVHEPRRYQVCGQAGPLGWEIPAAIGVKKAAPDAEVVGVVGDYSFQFLVEELAVAAQYDVPFVLIMLNNEYLGLIRQAELPYGMNYEVDIHYDAVGTDNVKIMEAYGCSGRRVTRPEEIRDTIEWARKEAARTSRPALVEILIEREANTPHGPAIDAVAEFEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHU4</accession>
    <name>A0A011AHU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850958.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2600170_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="79" mass="8717" checksum="23AE465BEF0B64DD" modified="2014-06-11" version="1">MGALVVAAGYVGVIVGLVVLAARVRKRGISAPILDVFDEMYRPSAHEARFEIFAEEHRTAPNQTPDDDEPPVTIRRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHV5</accession>
    <name>A0A011AHV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ORF">CryarDRAFT_2713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850966.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2674"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_11"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="257"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="408"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="54776" checksum="53DF22ECB4043B05" modified="2014-06-11" version="1">MVSRYVIAIDQGTTSTRCIVFDQAGRLVSVSQREHRQLYPKPGWVEHDAAEIWRNVQRIVPRAVAEAGIEASQVVGIGIANQRETYVLWERSSGRPIGQALVWQDTRADALVDDLSSHADAKDVEARCGLPLATYFSAPKLRWQLDHVPGLRERAERGEVLFGTMETWLIWNLTGGVHVTDVTNASRTMLMDLRTLRWSPEQLDFFGIPAAMLPEIRSSAEVYGVCTSVLPGVSITAALGDQQAALFGQVCFAPGDAKCTYGTGSFLLLNTGSEVVQSTHGLLSTVGYQIGGAPATYALEGSIAITGSLVQWFRDSLGLISTAPEIETLARTVEDNGGCYIVPAFSGLFAPYWRSEARGVIVGLTSYITKGHLARAVLEATGWQTREVVDAMNADSGLDLRTLRVDGGMTSDNLLMQFLADVLDVPVVRPMVAETVSLGAAYAAGLAVGYWADLATLRQNWHRAAEWRPAMAADRRAEEYDNWQRAVERTFGWIKPGAHHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI30</accession>
    <name>A0A011AI30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851075.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2741"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="587" mass="60854" checksum="FAEB4FD4962FC4C0" modified="2014-06-11" version="1">MILPVATARRTGAWLWAELRVRKAEGLLTLVVGLVAAASSIVPVYTLGYLVDQVRADASTGVIVQVSVVVLLAAVVSGGAMGLSLVLIARLCGRILADLREQVVDRALTLPTPVLERAGKGDLLSRVGADVAAIGSAVTQTVPNLVWSVLLGTLSLVAMAGIDWRLGLAGALAVPAYTFALRWYLPRSAPGYRAEREAVAERGQLLVDSAQGLPTVHAYRLEQRHLTEIDQASVRARDVLVSLFDLFTRFVGRVNRAEFIGLSAILVAGFFLVDSGAVTVGETSAAAVLFHRLFNPIGMLLFSFDDIQAGGASLARLVGVVDMEPETSPAAGAEPADASLELSGIDFSYDGAAQVLFGVGLRVEPGERVALVGSTGAGKSTLALIAAGSLRPTRGVASIGGVPVDSLPDPRRHVAIISQETHVFAGTLLEDLRLAAPGASREGASAALAAVGALGWAAALEQGLDTPVGEGGHELTPAQAQQLALARLVLLDPAIAILDEATAEAGSAGARDLEESAAAATTGRTTLVVAHRLTQAASADRIVVLEHGRIAETGSHAELVASGGRYAELWAAWEGRTPRACLKSWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK79</accession>
    <name>A0A011AK79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nuclease of the RecB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852130.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3512"/>
    <dbReference type="HOGENOM" id="CLU_760045_0_0_11"/>
    <dbReference type="OrthoDB" id="1489067at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="362" mass="39955" checksum="5EA8E5C53AF553F5" modified="2014-06-11" version="1">MPVEIALWRADTDPPSRLAPTGVPLESQLEQLIETDPAILGEPLLLIGRQVPTGYGTFIDLLAVDAEGGLHVLELKRARTPREVVAQTLDYGSWVVGLSHSDVHEVFAGYRPGLPFEAAFAERFGAAPPDELNTRQHLTIVASDIDPATERIVSYLNTGFAVPVNVLFFRYFTDADRSYLARTWLLDDAPSIGGRPTGTRRGTREEWNGQDWYVAFGEEAGSRNWDDARSYGFVSAGGGTWFTKTLRALPVGARIFVHIPKNGYVGVGIVAGPAQTSTDAVLTINLDRQQFTDLALQGSYRLGEPIDPDHAEYIVPVEWIHTRDRDQAIWQRGMFANQNSACKLRNQFTLDALSRAFGLENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKI9</accession>
    <name>A0A011AKI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852323.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_1_0_11"/>
    <dbReference type="OrthoDB" id="1079953at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="35517" checksum="075AB8011EC76818" modified="2014-06-11" version="1">MAATAAPRPLQAVLDVAAAAALRAPSVLNTQPWRWIVHERSLDLRADPGRQLGAVDPEGRMLTISCGAALDHALIALRTEGYDARVELLPDARDPELLAAIYPAGHHTPLAEDFRRYQTTLRRHTDRRPFGPDPVTEDMIAGLTGAALAHGVHVHVVRDDQVPTLSALASVAAGEELADPAERAELARWTRRAPHATEGLATDVTVQGSPRRVPLRPHAEDAAGRLPAGPGNDSGARYLILWGNQDGRRAWLRAGQALSAVLLTAAESGLAASPMTDLVEVTDTRVSLRRLLSWQGHPYAVLRVGVAAADLGVPAAHRLGHDEVVEIDRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKM3</accession>
    <name>A0A011AKM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852383.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3677"/>
    <dbReference type="HOGENOM" id="CLU_027128_1_1_11"/>
    <dbReference type="OrthoDB" id="538961at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459606" evidence="1">
        <location>
            <begin position="33"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="432" mass="46470" checksum="673A952E0465BB37" modified="2014-06-11" version="1">MSITSRRLRALVATGAAGMSMVLLLAGCGARAGDDTAAQGSAPAASCVDASGATIKLGFLNSLTGGMAISEKTVSNVLHMAADEINAGGGILGKKIQYVQEDGATDWPTFAEKTEKLLTQDCVAAIFGGWTSSSRKAVKPVVEKHNGLFFYPVQYEGLESSKNIYYTGATTNQQIIPAMDFLKSRGVKTLFLAGSDYVFPRTANAIIKLYAAKLGIKIVGEEYVPLDKDDWTSQVAKIVKAKPDFIFNTINGSSNVGFVKAYYDAGLTAAKTPIISVSIAEEEAPAMGHEVTGHFASWNYFQSLKTPTNPKFIKSWQAYPNSSGVTSDPMEAAYISLYLYKSLVEKAGSFDVDAVNDAAKKNTITFDAPEGTVTLDGENHHISKPGHIGQINAQNQFTVVWASDKFIEPDPYLEKYDWFPSDVRKQLTDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKR7</accession>
    <name>A0A011AKR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="20001" checksum="77C71F65E8BABF7D" modified="2014-06-11" version="1">MFRVRRPAVHHAFMPKHESRMARRTVHLDEVDRQLLDLLRKDARAPVNQLARAVRLSPAPVSRRIARLEQEGVIRGYVTVVDDRAAGDVHAFVEIRLTGETETGELEEWLRRMDEVENFFTVAGDPDVLVRLRVHDVDHLQRVVNSIRRTGKVTGTKTMIVMYDWTRGEDVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKT9</accession>
    <name>A0A011AKT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3740"/>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459607" evidence="1">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="97"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="520" mass="54127" checksum="1E12C7D08A427688" modified="2014-06-11" version="1">MKKTLLWSTPVVVAVALAAGTPALTPTRTVEVANASLSEAPAVRWGPCPKPPAGLAVDPRQRCATVRVPLDYTKPGGKTIPIAISRIPATGKAARRGVLVLNPGGPGGEGLNLPSTFTRTAGKPVLAAYDLIGFDPRGVGHSSPVTCGLQPAELVPPYPYPDRTGSIAANVAYATSAAQRCGARSGDLLPYVTTANTARDLDRIRAALGERTISYYGTSYGSYLGAAYATLFSSRTDRLVLDSAVDPSKVWYDQFRTQSRGQAIRFPDAAAYVAANAATLRFGRTLSAVTASYTELTARLDAAPAVVPGAPVPLSGAVLRGLTTALLSSDQYFPMLGEGWRAAADLAAGHATGKQLRTLQGLFGAMNVAAASSPGVPTDNAIASAYAVACGDARWPRDLREYARNVAADRKAYPLSAGAPANLWPCAFWPTQPVGKPVAVSGRGARNILILQNERDPATPLETGRGMHRALGHRSVLVTVNAGGHVVYGSNPHGPTACASRAADTFLATGTLPHKDTRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKY6</accession>
    <name>A0A011AKY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3790"/>
    <dbReference type="HOGENOM" id="CLU_053843_0_0_11"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="409" mass="43239" checksum="9A6A45B55EE68F05" modified="2014-06-11" version="1">MTPDNRPVPTVGGVAADEWLARSVPALVPGVVAALVDHLPVYASLPPEELRRDITGVVRQSLRGFARYLREGVLPEGDDLLALRESATRRAEEGLPLGTVVDAYFFGAQHVLDEVARRAGPHEAAGLPGLCGAAFAYLRPVVGAVLTGYLHHANASGNTDRDARQALLAALLDGRPPADHTAISRPAGYLVLSIGIAPHPDETVSGVDPAVAASRKLRRLRTELHHLTRGRALTRLSSTGGLVLVPIATAPGGLTDDDWQHLRSDVDRLRRHCAAELTVGAVAADPPGVAAAARLAAEVREVATAAGRGPGVHRLPDVLLEYQLSRPGPARDQLASLLDPLAGRPELLDTLRTFFECALDRRRTGAALCVHPNTVDYRLRKITALTGLDTVPGPGTAMLHAALTARAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALR2</accession>
    <name>A0A011ALR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-mannose binding lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1522712_0_0_11"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459615" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="87"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="19283" checksum="630FDE66E2241CBB" modified="2014-06-11" version="1">MFRRVIITVLVAAASVLFVTGPAQAFPATACDRTAGPEGRPGDYKDYTSPLDRTVWTHNMYACQWLDNGKSWTFYKGTATLRMVNGDLGVYNKAGVRKWHTNTAGSGATQMLFQQDGNLVLYTSGYGRAVWSSGTYNKCDRYSEFPILATQSDNNLVIYCGIAGTKAIWATHTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM27</accession>
    <name>A0A011AM27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853298.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4201"/>
    <dbReference type="HOGENOM" id="CLU_043113_0_0_11"/>
    <dbReference type="OrthoDB" id="806638at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="489" mass="52844" checksum="0FD5A98947B89F49" modified="2014-06-11" version="1">MAAERHGVRFPDVDGRRSSSRTGADIVADSLVRVDGRLAGQARQATEWRKDYAEYFAASTRVSALAKDSVAIAEHGLQSAWDRLVFRGADGTQTPLTAWARDLPADDRLTTAHVDGDAERLTRVEVPYRGQVLHGVALERQLREWVRRGIVEQGFADAVQSVVEQPERLALDGYEVILLGAGAEMGPIEPLLRWGVRVVAVDVPNPAIWERLRGLPSAGTLTYPQLDDVPGVDIGADLPALAGWLSARWSGDRIPILGSHAYADGAAHVEVNLAADVLARTLTTARPDAVLSYLHTPTDSFLVPSDAVAEARERGRSRRWNSAAHRAAALASGRRLFRPAYPETYADDTGRAWGLSDTLVPIQGPNYALAKRLQRWRAVLQHSAGRRISSTVAPASWTRSVTKNRVLNSVYAGAGAFGVEIFQPDTARALGAAKLVADVHRPLASADAHPESVFIDAAHGGLWRQPFDPRTALGVAALIGGPKALFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGA4</accession>
    <name>A0A010YGA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUDIX-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059078_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="29929" checksum="C68B3A3EA7C5CB4F" modified="2014-06-11" version="1">MVSGVRDAATTVLLRDAPGGLEAYLMVRSTRLSAFAGLTVFPGGSVDPGDHVADELWRGPDPARWPLSADPGLSRALVTAAVRETFEEIGVLLAEGASFPSADELQRDRAALEDHRVTLPELLTARGLVIRTDLIRPWTHWITPEAEKRRFDTRFFVAGLPAGQDAQQPSGEATRGFWQSPAGALAAVERGEFGMLPPTASTLLGLVEFGTLADVFAAAENRTIRPIRPVYRGDAEGPRLTLPPESLELLPPGVTPEFIAGLMSGIARHGRPPATEKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGN1</accession>
    <name>A0A010YGN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA synthetase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848051.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.439"/>
    <dbReference type="HOGENOM" id="CLU_026233_1_0_11"/>
    <dbReference type="OrthoDB" id="749518at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="334"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="50300" checksum="2F752CE12B5704D8" modified="2014-06-11" version="1">MTALHHIELRRGTYRDSVQLLQVSQAVSGLDGVTGAMVAMGTELNLELIAGMGFALPDDASAGDMIVAIAATDETTRDSALAALESALAAKTPAVSTDATVPPPRTVGAAVVTAGADLVLISTPGRYAFADAVDALDAGASVLVFSDNVPVEQEIALKDLAAERGLLVMGPDCGTAVVGGVGLGFANVVRPGPIGLVAASGTGAQQALALLDAAGVGVSHCLGVGGRDLSAEVAGRSTLAALDALDADPATETILVISKPPAPAVADAVRAHAATLSKPVVFGLLGRDRPDLTAVVTEVLGADAPASWPKWLPTDEPRDLVAPFSTGSGALRGLFSGGTLADEAMVIASAALGPIASNIPLDPAWALGSDLKTDGHATIDFGDDALTAGRPHPMIDGTLRLDRLAVEAADPSCRVVLLDVVLGHGAHPDPASELAPAIASALGVADRPFDVVIALVGTSGDPQGLQRQADALRGVGARVYLSNAEAAREAVAILKPSEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH37</accession>
    <name>A0A010YH37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SEC-C motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848333.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1666482_0_0_11"/>
    <dbReference type="OrthoDB" id="1177251at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17710" checksum="4C232B84957C535F" modified="2014-06-11" version="1">MTERGPAEPTLDARIDSFLRSFARVRGQRKTRKPRRTKSLRVLVYWPADQWDEMAARWPQFVPEYGDDHATHRRNVEDMLRAQSEDSEASFGVAALTVEGLAGFAQEQDLDAATSETRAAYAAELGRAGKATSWPPSPTQKCWCGSTRLYRDCCAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHB8</accession>
    <name>A0A010YHB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine reductase, riboflavin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.699"/>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="21860" checksum="9E03BEA1A67C48A3" modified="2014-06-11" version="1">MATVTGARPYVVVSAAMSVDGYLDDATPDRLLLSNDEDFDRVDDVRATCDAILVGAETVRRDNPRLLVRSPARRAAREQPPLRVVLSRSGRLDPAAAVFGPGAPTVVYRGEPLPVVLDDLVSRGVRRLLVEGGGTVQAQFLTAGFVDELHLVVAPFFVGDPAAPRFAGPGRYPHGAADRMRLAEVRPIGDVVLIRYLLGPPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHH7</accession>
    <name>A0A010YHH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848494.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.756"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_11"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="23317" checksum="BB544EEE66002625" modified="2014-06-11" version="1">MVAGESRVRAPLITDELRQAIVTGELPPGERLTEPALAQRFGVSRVPIREALRVLASEGFVEVRPYWGTRVAELPSSAATDLLELRGAVEPLAARKAAKRRTPEQLHAMEATLAAGTALIADGRLDELPALNGQFHLLLAEASGNRLLAETVQQLRAKTEWVYASRVDHRAGHSWDEHLAIVRAIRDRDEELAAALVAAHIRNASAALDPEPDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHS0</accession>
    <name>A0A010YHS0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848595.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.845"/>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_11"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26975" checksum="6886DDFA80D8CD8D" modified="2014-06-11" version="1">MTTLVRDTTVVFSRELRPVLRSPFSLIFTMVQPVFFLALFAPLLPDDVSPGSGSSLQWFVPGIVVMSCLFGTSVTGSNLQLEMQTGSHERMLVSPLSRPALLIGRALKEIVPMLAQTVVLILATIPFGFRLHPVGVLVGLVILSVFCVGLGALSYALALASEGQEWIFWTVQQTLLFPLLLIAGILLPLDDGPGWLKALSHVNPLTYLVDAERVLFDGEVLSTTVGAGLLAAVLVGVGGLWVGIRAMRRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ12</accession>
    <name>A0A010YJ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trans-aconitate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849018.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1261"/>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28633" checksum="26D38DB5E4B19EFC" modified="2014-06-11" version="1">MEQHTASDVEPERPSAARVYDYYLGGSHNFAVDRAMAEQAIRILPELPGNMRANRAFLRRAVRYLIAQGVRQFLDLGSGIPTVGNVHEVALGEAPDCRVVYVDNDPVAVAHSQSILEDVRAATIVQADVTDPGAVLAEARRHLDFERPVGVLMVALLHFVPDSAAPASVIARYRDAVAPGSFLAISHGTADQQGDRGPAMEALYSRSANPLVSRDRATVESFFEGYELVDPGVVFVPLWRPEPGALPAATPPERTATYAGVGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK19</accession>
    <name>A0A010YK19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849544.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1640"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28703" checksum="24008D564BEB917F" modified="2014-06-11" version="1">MTRLKAEHVALGYDGRTIVPDLDLAIPDGSFTAIVGANGCGKSTLLRGLARLLKPGRGSIVLDGKAIHEYSSKEVARRLGLLPQSQTAPDAISVRDLVARGRYPHQTLLRQWSPADQRAVDSALELTGVTELAGRLFDELSGGQRQRVWIALALAQETDILLLDEPTTYLDIAHQIDVLDLCARLRTERGSTLVAVLHDLNLAARYATHLVAMKSGAIVASGHPVEIITPSLIEQVFGLPCQVIDDPESGTPLVIPRMSTLKEVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK39</accession>
    <name>A0A010YK39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710211_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458858" evidence="1">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16775" checksum="C84EFF9677D38C4B" modified="2014-06-11" version="1">MRAMNPLWSGARRSKRTAVAAFVTALIAVVGNMFTASPAAAAYADCYNYLGTICLADNTDVTGQIWRQYPNQIGSCRNFSAEGFNDKASFAWFNIQRPSSAPRPHVVLWRHAGCSGTSGNLGMTLDPGQQWHGERQTNGEFNNQISSISISYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKH5</accession>
    <name>A0A010YKH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569948.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="410"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="559"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="755" mass="80959" checksum="8614D6746CE2BB94" modified="2014-06-11" version="1">MTFSPGSGNKRAVNHDGALPGAAEDREEARRRAAAFSAHRRAVCRDELCRASAACGLVWLVVYQVLAVFASDSWAAPLVTDALYLLPIGAAAVAGVFAVRASSGRLRRIWAWLAVSHVCWLIGEVIWSVWGVWLSDDRLAAAVDTDKSIPLSDVAYTVSYAALVPAAWIGFVETRRLWRARALLDAALVVLAVGSIGWRLLSGSDPVNPDVLVDLAYPAVGLLFVLALIGAGLSGHRGVPCSILLTLVGFGIGIVADAGYAFADAGNSFSDTSPLNLGWQAQAVFLTLGGVAAIRHPDVEPPVERFDHDRAFGAVLISGLVVALLVGVDQIRNQKVDTVWLGVTALVLAGLLARQALTTRERTRLAKELDEALQEQRRTAVTDGLTGLYNRPFFQALLGVEARRALHGNGRAALILVRLDSFAGIGEQHDWAAGDTVLVQVADRLRIAARPGDVLARYGVEEFACLLPQTDEEAAMEVAERFRQALRRTSIVVGSGASVAVTASFGVATATGQTALAEDDDEPMLDMDRLVRDADRALNDANERGGDRVVVAGRADRRTLADDVDVPPELAWLADRVDRVLSDHEHSTAVARWCLLVGGYLALDHIELRQVVAAGRLHDIGKFGVGAAILRKTDPLTDAEWGALRCHPEEGARLLRGVGGHAALAPLVAAHHERWDGLGYPEGIKGEDIPLGARIIAVCDSWAAMRVDRPYAPALNTRAARDEIERARGTQFDPIVVDAFLALLDQDLIDDPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKQ6</accession>
    <name>A0A010YKQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849872.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1848"/>
    <dbReference type="HOGENOM" id="CLU_117223_1_0_11"/>
    <dbReference type="OrthoDB" id="1912696at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="15395" checksum="309BE5E2FDA4A439" modified="2014-06-11" version="1">MSATAGHADGVKSPADRLGIQPGQVVMEIGFDDDCADELRDAVAERVGDDLVDEDSDEVVDVVMLWWREDDGDLFDALVNALSPLTDNGVVWLLTPKAGRPGHVEPSDISEVAPTAGLQQTSSISAAQDWSGARLVAPKAARSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM91</accession>
    <name>A0A010YM91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">CryarDRAFT_2436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570058.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2399"/>
    <dbReference type="HOGENOM" id="CLU_001201_0_3_11"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="38496" checksum="F8A929F092807EC3" modified="2014-06-11" version="1">MSDVTTIHVGGDQPYDVLVGHGMLGELAPLLQGAQRVAVIHPGALRTTGEAVRDDLRTVGFEAHSLEIPDAEDGKTLEVAGFCWDVLGQAGFTRTDAIVGLGGGAVTDLAGFVAACWLRGVRVVQVPTTLLGMVDAAVGGKTGINTAAGKNLVGAFHPPAGVLVDLATLATLPKHELVAGMAEVVKTGFIADPRILELIEADPAAATDPASPVLRELVERSIRVKADVVSADLRESGLRETLNYGHTLGHAIEKNERYRWRHGAAVSVGLVFAAELGRLAGRLDDATADRHAAVLKLLGLPLTYPAAAWPKLLDSMRVDKKSRGNRLRFIVLDGLGKPTVLEDPDPGVLVAAYSAVGTESSPGPAVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNB3</accession>
    <name>A0A010YNB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851093.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2756"/>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_11"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="47"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="33600" checksum="A9A47CD8B5C5AFC1" modified="2014-06-11" version="1">MLSSALNRASRSRRVRRVVERVPVTRRVVDRFVAGEEIADVVLAGEYLRRQGRSVTIDVLGEDVTDAAGAAATTAAYLALLAALAEKNCAEGADVSLKLSALGQALPGSGDEIAESNARAVCEAAAAVGATVTLDMEDHTTVDSSLAIGAKLRVEYPLTGTVLQANLRRTERDLAELAQPGTRIRWVKGAYREPRSVAYQQKAEVDDAYRRGVRSLMESGCYPMIATHDPAMIEHALRAAARTGRSAADWEAQMLYGVSTGRQRELVEQGRRLRVYVPFGTDWYGYFMRRLAERPANVAFFLRALARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPC8</accession>
    <name>A0A010YPC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2664936_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="75" mass="7990" checksum="80370181A523D2A3" modified="2014-06-11" version="1">MGPMLTPRDGLLGGDRLRTSNTVAMIRQPDGRVRPLLFDSSPLLPSAVMGVLSVAMLMHLAERQTSSALRSSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPH4</accession>
    <name>A0A010YPH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851669.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3190"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="28924" checksum="8C50A91427A80798" modified="2014-06-11" version="1">MKLAGKVAFITGAARGQGRSHAVTLAAEGADIIAVDLCAPLDTVGYPLATEEDLAETVRQVEALDRRIVARVADVRDTAGLRAAVDEGVAELGRLDIVAANAGILSSGSTQELTEAAWREMIDVNLSGVWRTCKVAIPHVIAGGRGGSLILTSSVAGLKSYPNVGHYVAAKHGVVGLARTLATELGPYGIRVNTVNPTQVDTDMIQNDVMYHLFVPDEDNPTKEQFAAASRATGLLPVDWIESRDVSEVVLFLASDAARYLTGIALPIDAGATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQL7</accession>
    <name>A0A010YQL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3650"/>
    <dbReference type="HOGENOM" id="CLU_127487_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="15560" checksum="8C4B045155408FC9" modified="2014-06-11" version="1">MIALDTEPMRPLSPSLVVLDRDECLALLSSVPVGQVVFTDRALPDVLPINFRLDGDAVVIRVATGSRLARAAAGAVLAFHADRIDEATHTGWSVTVVGRATEVTDPAERQRLDELPLRSWIGDTRDHFLRIPAERVTGRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQN9</accession>
    <name>A0A010YQN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3676"/>
    <dbReference type="HOGENOM" id="CLU_016274_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="33259" checksum="E8D9A6A6CDBA5DBD" modified="2014-06-11" version="1">MGVSADGVLLAVDGGNSKTDVAVLDRDGTLLARRRGPGFSPHVLGVAGSVLAVEELARSTLSAIGLGLDPAAVAHTAAYLAGVDLARERREMLAAVTARGWSRSAVVDNDTFAVLRLGSPDGDGVAVVCGAGINCVGVSGSQVVRFPSLGTVSGDWGGGLQLGAEVMSAAARAEDGRGPATGLAAAVTAHFGVDSVLEAIEAFHFGDFPATRFGELSPVVFRSAAQGDAVAGRLVDRLAAEIADYVCASLRRLELRDRATPVVLGGGILAGGDERLLAGVVDRVRPEFPLARFVPVDEPPVIGSALLGLDHLGIAGDGVVRAAFRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR65</accession>
    <name>A0A010YR65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_10_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15099" checksum="7ECA0F400F5E3DF6" modified="2014-06-11" version="1">MTIAAAVLLAVVLLVGAGVGVVRRTLAVVTVKGVSMEPTYHRGDRLLVRRAGVGGLEVGQVIVVAAGRPVGTPPLDSPLWMVKRLVALPGDPVPRSDTFHVRAAADDVTPPGCLVVAADNPDGVDSRQLGYFAGENLLGVVVRHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVX3</accession>
    <name>A0A010YVX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847804.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144751_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14983" checksum="F2202A63394D9762" modified="2014-06-11" version="1">MDTRGLQARADELMEEFHRLRSGVTELQQQLRAIRVVVQSDDRLVTATVGPRGQLVKLELDPRIYRDPNSRKLASTITETIQQGARQVADRTLELCRPFLPQQDLRAQLDGDLDSFFTRLDNEVMSGDAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXC6</accession>
    <name>A0A010YXC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein with SCP/PR1 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.853"/>
    <dbReference type="HOGENOM" id="CLU_086896_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458921" evidence="2">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="126"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="26080" checksum="0B0D375ED6A3C6FB" modified="2014-06-11" version="1">MHRRRRSPNRARLVIGGVAVVAALATGGIAVVGLTGEDSGDASAAIQTAETLVPQATDYPAVDESAQPSESASPSASAARPRLAGGPPRAATGTTAGPKPGSASPSPRRSTKAPGASTGSPELAVLARINEARAEEGLGALTMDTKLVAAAHEHNLQMADGCGLSHQCDGESGIGDRISAQGVSWSSVAENVGTGGPVDDNASGQTQMAVGLTDSMLAEVPPDDGHRKNILNPDLTRIGVDVIRDENGTVWLTHDFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXH6</accession>
    <name>A0A010YXH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase, nitrate/nitrite-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569739.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.923"/>
    <dbReference type="HOGENOM" id="CLU_551771_0_0_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458195" evidence="2">
        <location>
            <begin position="26"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="494" mass="50413" checksum="84E42DD232A88FC9" modified="2014-06-11" version="1">MTLRRRLAAVLLSVVLGPLLLGALAVGITATRLAEERATERLSAAATVVSTAVNTVCQRARSAAEGLADATAQGRRPAAATSFLVTRGLAESARIENIAGTALGVAGDVSVPVTRWGDCTKGTPPGNDARAVIAAVVELHRADGSLAGRARAAFTVTAADLDALVSVPGVEVTAVTGALPGVAKNASPGAAKNASPGVGKKSETDVRSATLRMRVLEPVPGRPVRTVLRTPAPDATALYGALSVVVLTAAGAALFAANSLAKALTTPLAEVAAAAALVAEGDLAARAPVRVLDEVGQLAATFNRMTRSLQAYVAALTAGRDQLRGTLALLGDTMSSTNDVDRILDVVLESVVATTAAESGVVLLAEERDLVGRRSLGRPHDVRVAIGEGLLGGVAATGEARHGRENCRTFIAVPIVGPPHPPALPEGRLLGVLALHDRLGGDDFDDGDLLTVRSFAGQVAVALENALLHRATDPIRPHRALRAVSRALRAQPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXI9</accession>
    <name>A0A010YXI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17104" checksum="A28180D3F0DA8018" modified="2014-06-11" version="1">MTAMSTEREALVRELDNGGRALATAAVLFHAAVAALSGLTASDQRALDLIERFGPLTAGELAERSGLAPASVTGLLARLERRGLARRVPNPNDRRSVLVELVYEGMTVMGPHFLELGRQLHQLYESFDDAELASIARFLREAARIQQDAAARVPSPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY44</accession>
    <name>A0A010YY44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848919.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1173"/>
    <dbReference type="HOGENOM" id="CLU_031317_3_0_11"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27210" checksum="438904BD21B371B3" modified="2014-06-11" version="1">MKLSVLGCAGSFPGPDSPCSSYIVEADGFRLLLDFGNGAMGALQRHPAGLHGIDAIMLSHLHLDHMTDACVYMVVRRYDPDGKHPPLPLYGPAGAGERIASMYGPEEGVGGSVEDVYDVKTLQPGRFAVGPFTVEVARVNHPVETFGVRIEHGDTAMAYSADTGRTDALVKLARDVDLFLCEASYLEDKPHPPDLHLTGFEAGEYATQAHARRLVLTHFVKAWGDPEQSLEEARRSFAGPIDLAYAGAEYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZS2</accession>
    <name>A0A010YZS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849727.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1759"/>
    <dbReference type="HOGENOM" id="CLU_032968_0_0_11"/>
    <dbReference type="OrthoDB" id="1551591at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="663" mass="69298" checksum="FED8289C01C4194C" modified="2014-06-11" version="1">MSVVLPPVDGVVLADAVDALPGRLRKRLDGAVAKVAGYAISVDGPEWTVRIDDATVVTLRTVDGAVRASDDARCSCLLAPACLHRAATLAAAPATDDDDESRPESPAPNEPSAGPDATTTGSPTLHADDTSPDPARTGAVGPTRSDASAPAPPGTHARSLTEAQTMAVYGVWEAAGAVLAAGTTGSGAVLRAALLRAAHEARAHGLHHLAAGARQVAAHLHDARTAAPHYRLATLADDLRELLLLAHRLRDPATPAGELPALLGTARREYTPRGSLRLHGLCTVPVLARSGHAGTATYAADRDGTLWLVADIYPGGAERAATTVDAAIPVGEGVLSHRELARTGLMVTGATASASRQLGAGRDVRAVRAGGAPWTESPLAPLWDVPVESQLDRAFAALPLPVQDRPTGDDLLFLRVEPVAPGDGGVVAVTADGRLVTLVAALDHPALAYRDNLRVLGTAAGVPLLVIGRPDPTRPGHVQLLALAPDRTGDQPSDPTGDQPSDPTGGDQPPDPTEDQPPALRLPPEWAGHADLGYDRLHSSMITGDRSAPGIEPTERSPARHDHALELLRRHLDRAVDGGRAVHAFARPDQRLLRRARWDTGADLLAALEAAARPGRRDVFGRLADDDGRRFVLAWLAAAVYEQTAAWALSRAAWSPEEERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0V8</accession>
    <name>A0A010Z0V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850234.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_2_11"/>
    <dbReference type="OrthoDB" id="1233189at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="229" mass="24517" checksum="E43CB18365494705" modified="2014-06-11" version="1">MTWDWRWSWVTSHYDLLAELLGQHLYLSVVPVLLGLLIALPLGILCVQVPRLYAPVLALTSFFYALPSLALFVVLIDYTGFTGWTVIVPLTIYTLSVLVRNVVDGLRSVPEHVSQAATAMGFGGLRRLLQVDLPVAIPVVIAGLRVATVSNISLVSVGSLIGISGLGQLFVDGIQRSFITPIIVGIVLTVVLAVLADAVLVGLQWLLTPWTRTGRSAKPVSGDPAGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z143</accession>
    <name>A0A010Z143_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850357.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394267_0_0_11"/>
    <dbReference type="OrthoDB" id="2076761at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="655" mass="67712" checksum="1281FFBEE4A85B32" modified="2014-06-11" version="1">MNWLLRRAAQRWPADIRDDMEREWRGEMGAIDGPAAGLRRLTFVASLAFSPPIPDENGVPRGWREHVPGRVGALSPFAALFLAGLATIIVRGLSSMVYRAAMGLFGLDLTSPVYERALPVTSVVPFGFAVFAGWWLARRTSTPDNRAYAVWPASTVIVAAGLAATVPVWIPVVAVLVWAPLMVWVTRRAAAAPGRRAMAYAVPGTVVAVVLAAAAVALPLVLTTVVGPAAALRYLVGVLPGRATFAAPTPGNADETLYLLVHASDVLTQLPMFSLLVLSFGLTRSRRIPATPPETTPAPVRIGRPAAAAGLTGLALAVVAWAYTLTVLTPAMPGTAAAAPMPGGDGELYLWVAELRWASILLAAVCLFLAVVDRPRAVASAGVLGVALLGADGLGERLGAEGLGAFALALAVGGVAAVSAAKLAGPSYPHAVVRQRLTATAIAAAVCWPLLGAQSTPLVNHPFLPLGLPILTTAVMLAFGVVAVLAARTARGRESGAATALFALVAAALSVGSGVVQHVYGDEQPDVFLLLEILYLPVVAWILLHREGSRRWTAVARWAGLTLVTPALYAAFVYGGVSGPAEALFRWNGTSYPADGISLVPGCAVLAISGAAAAAGLLVRRARPPLPRPRALAPTRSRPESPGPEASGPLPSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2C0</accession>
    <name>A0A010Z2C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850937.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2651"/>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_11"/>
    <dbReference type="OrthoDB" id="1260864at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="25851" checksum="AC6BF14DCC8FAF0F" modified="2014-06-11" version="1">MKFTENDVALVTGGASGLGLATAEKLVADGARVVLLDLPGSDGAAVAEKLGVIFAPGDVTSEQDVANAVQAATEIGTLRAAINCAGIGNAIKTVGKEYKPFPLDGFQKVIQVNLIGTFNVIRLAAAQIAQADEVDGERGVIVNTASVAAFEGQIGQAAYSASKGGIVGMTLPIARDLASLKIRVCTIAPGLFDTPLLGGLPENVKTALGAQVPHPSRLGSPVEYGLLASQIIANPMLNGEVIRLDGAIRMTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2X7</accession>
    <name>A0A010Z2X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029929_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457792" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="28471" checksum="60AD09307C1E72A2" modified="2014-06-11" version="1">MSTVVIGIALALLSSVAYASAAVVQERLAELPVSGLAKNPRWWIATGLNGVAAVLHLAALRAGPLSLIQALGVLTLPMAVPMAAATWRRRVSVLEWKGIVFTLAGLVGLVLLIGSAGTGGELTLTQLVALLVVAAAVLIGLEGLSRTPRASLLWSAAAAGVAFGTSSAVSQTITVRLADAGLSAVLTPLVLIAGAAVAVLTVAGLLLTQRSYRDGLGAPLAVSTIANPIAAAAIGILLLGDHFTGGYPGSALALVCATGAAIGVTLLASAPHDGRSRVPVSATRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z317</accession>
    <name>A0A010Z317_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570202.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2880"/>
    <dbReference type="HOGENOM" id="CLU_026673_9_0_11"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34334" checksum="0D584949343BDE80" modified="2014-06-11" version="1">MTTHALWFTAPRAIEIRAVDDPEPGPGDLLVRTVWSGISAGTELLAYRGELNPSTERDTTLSALADGGFDYPFQYGYSCVGVVESGSLTGRTVFAFHPHQDRFVAGEDDVVVLPDDLDPRIGTLFPLVETALQLTLDAGPVLEDTVVVTGLGAIGLLTSLLLHRAGASVVAVEPEATRRERAHELGLHAVGPDEAPGEVPLLIETSGAPRALADGLALLAHEGTALVGSWYGTKPVPLPLGEHFHRRRLTIRSSQVSTIPFAAQGRWTNARRRVTARGLLSELPLKSLATTEFAFTDAADAFAAIDRGDPGILHTALRYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z390</accession>
    <name>A0A010Z390_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851345.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2959"/>
    <dbReference type="HOGENOM" id="CLU_041278_1_0_11"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="370" mass="39651" checksum="79A3F3DCC31AA200" modified="2014-06-11" version="1">MDQRELLADALHDRADLLAPAVYGEIVAHIPSYENVPRADVEASVREIVADVCRLIRTGTVPPPASITQAEESSRARAKQGVPIHDIMHAFRFTTGAIRDAVLDLGIDALAVVTLLWAYSDAYTANVVGIYRQSDIEGALEQARRAQQFLLGLLDATLSDGDLEVAASALLLDPTVSYRAVRALPLRGDVAPQLRELQRQAARHPGVSVLAAIGTQCVGVLPFRPDAVGDDVLIALGPSVPLPELARSFRSAHTVLTAGTRLGLTGTHALEDLSWRAAAAHAGEVNGMLRARYLDPVAAQGPFGALILEAVAAYLAEDRNVPRAARVIPVHVNTLRYRLRRFEELTGRSLDSTETIVEVSFALGVSAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3G1</accession>
    <name>A0A010Z3G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851458.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3027"/>
    <dbReference type="HOGENOM" id="CLU_1183440_0_0_11"/>
    <dbReference type="OrthoDB" id="1566928at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="234" mass="25090" checksum="623582FDE75F826B" modified="2014-06-11" version="1">MGFAQEVRAAFRRGDTAAVTLLAQAEVERARTTGDSAGEVEALYALARVALREEDRPRAEQLAEAALVVAMAAGDRALEERPRHVLAAVARLSGDHLTARERYRASIALNEELGRPETVTSESYNLAFTELHLGDLERARELFAAVRRRTADPAMLAYLAIGGAALARAEGDHERAAELLGSVDAAFAAIGQVPDPDDAAELAAVRDATVAALGEERFRERYAAGTSRRPDDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4I0</accession>
    <name>A0A010Z4I0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851928.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3368"/>
    <dbReference type="HOGENOM" id="CLU_090336_25_0_11"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="32"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16209" checksum="DDE4CD5026E881AF" modified="2014-06-11" version="1">MPPLPTASLPARRVQLRRWVLSSDAELQELRRGVFHAVTGRPLPSDVGLDGVAERMVLVASELATNALRHGRPPTVVTLFSTNDSYVLDVVDHDPHRVPEYAEGRPPGAGGLGLKLARDLASELGWYIDDDGAGSVKHVWARFFAPPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4S1</accession>
    <name>A0A010Z4S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133265_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="15175" checksum="27140FF89C7AF33D" modified="2014-06-11" version="1">MSLLERTAVTPDAPELRAWTAAERELLDRAPLIRVAGVRDDATLRPFVLIGHVRVGPDELVRSLNGIGGTWYRGAVRTGRGEIDVDGRRIRVAFLPDAGREDEVDRALHARYGNDSGVRRMTSPRAREATLRVVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4W9</accession>
    <name>A0A010Z4W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852162.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3531"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="842"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="906" mass="96882" checksum="18C183E213B88A44" modified="2014-06-11" version="1">MPHAELETLFGREVELANIRRFLQSIRHGGDMRMVRGEPGVGKSALLAAAADLADAEGMRVLPANGSEFEAEISYSLLNQLLLPLYTDMQKLPPALRDALTVALGFGSGPAPAALLVCNAALMLLTTVAKKKPALLIVDDVQWVDRPSAVVLGFVARRVRGTPVGVIAASRTGTESFLDSRGLTEVTVDPLSDEASARLVDTRFPALTDRVRQRLLDLAQGNPLALLELPGSLTDSTPPADVVPLSDRLQTIFATRIAGLPESTRLLLLLATFEGSGDLRTLRGLADLAPLAAADRAQLVRVNDAGGRIVFGHPLIQSAIVAMSTSEERQQAHQAIAAALPGDPERRAWHLAAATVGPDEVVAAELEEAAHVVLRRGDAFGAVAALVRAAEMSSTPEDAARRLAEAAYTGAEAGVAGDATTLLADARSMSQGPAGALHAANATALLMINGDGDVRTAHRLLAGAIETGEHGWRADDQALDEAMHTLLLLSSFASSPDHWATFHRLLARLQPEPGDLLSVLSRTFTDPVRTAAAALPDLEALIAALPGETDLTRIVRTGTASAHLSRLGDLREHSWRLVRQGREGGAPQWQVSGLMHLCEDDYYTGRWDEVEELAAEGERVADESGLPFLRWYFLLNRAVVAAGRGRFGEAYDLADEITHWAAPRGVAAMLAVAHLPRTLAAAAAGDFEAAYRHATTISPAGVLAPYAPTAMWVMLDVVEAAQRTGRTAEARAHAEAMRTADVAALSTRMRLIQHGVDALVLDDEAGDRLEQALADPATERWLFDSSRIRLVFAEKLRRRKEYSRAGTHLLAARTGFAAIGAEPWLDRTVGELRAAGHRPTAADRPPAALTTQEMEIANLAAAGLTNKQIAQRLYLSHRTVGAHLYRVFPKLGVTSRAGLRDALNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z537</accession>
    <name>A0A010Z537_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570538.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2205691_0_0_11"/>
    <dbReference type="OrthoDB" id="2101824at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11183" checksum="118E24A12A335453" modified="2014-06-11" version="1">MSDPVLLPVERPGRCGPRTIGAYVSDGASVRYQPAVDVERLVLGVVAVAGAAAVLGSALHRTPAVGPVSMGPGGWLSVRGARAPRARATDPGSRPWWAHALRARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z687</accession>
    <name>A0A010Z687_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852761.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3983"/>
    <dbReference type="HOGENOM" id="CLU_069356_46_0_11"/>
    <dbReference type="OrthoDB" id="1309950at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041669">
        <property type="entry name" value="TetR_C_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17918">
        <property type="entry name" value="TetR_C_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="22997" checksum="AAA03509D4C67D2D" modified="2014-06-11" version="1">MPSADRRLQPRRRPRQVRAELTRERILTAAAHVFVEFGYAAGTTNRIAERARISIGSLYQYFPNKDAVLAELLIRHVDRGVWRGADQLDLSPGSLEATVRALVRDAIDNHQDDPQLLRIMIEEAPLSQELLDTIARHGTQRVAQVRDVLARHPDVGVADLDTAAELILTTVELNTHKVMADPRTIGVDALERELVGMVTRYLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6I3</accession>
    <name>A0A010Z6I3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CryarDRAFT_4117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852979.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4090"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_11"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="420" mass="44861" checksum="23B642AE9455E374" modified="2014-06-11" version="1">MSDLHRPLAEIDPDVSAAIGAELRRQQTTLEMIASENFAPIAVLQAQGSVLTNKYAEGYPGRRYYGGCENVDVIEQLAIDRLKALFGAEFANVQPHSGAQANAAAMAALLQPGDTILGLDLAHGGHLTHGMKLNFSGKLYDVAAYHVDRESHRVDLAEVERLAHERRPKLIVAGWSAYPRQLDFAEFRRIADAVGAYLMVDMAHFAGLVAAGLHPSPVPHAHVVTSTTHKTLGGPRGGFILATADLAKKFNSAVFPGQQGGPLEHVVAAKAVAFRLAATPAFRERQERTLAGARLLAERLLADDCRAAGVGVVSGGTDVHLVLVDLRDSPLDGRQAEDRLHDVGITVNRNAVPFDPRPPMVSSGIRVGTPALATRGFGAEDFTEVADVVAVALQPSPDVEKLRERVTALAGKHPLYPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKN8</accession>
    <name>A0A010ZKN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731125_0_0_11"/>
    <dbReference type="OrthoDB" id="1505780at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459079" evidence="1">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="348" mass="36107" checksum="AADD7C2C6AA4B85D" modified="2014-06-11" version="1">MGAVVLTMVLLVVSACTFSQREIEDPGWTTIALPDALPRTLAVDGNRVLVAGERGRYAPAAWIVGRSVTTVVLRPHSPYGPTADLVAATLSGDTVAFAGQRPGGAHGIPRWTIWAGTVSGGADDLPQTFETFGGPDSLGLVGLQTVAGKPLLLGNWADGQPGPAFWRASGTRWARVPSTLAGFLASGMGVSRGRPVVVGHSTTGGSLRPTVWLGAPDLRSWRALPLGNAPVARALDLSCAGPTCLVVVRTPGTGVAVWEVGGTARELPTPKMARDAEWAQVSAGPDGGRAVAFGSSERSVFCYWKADGWRYAVPPVGVVRDLATVGNRFVAIVGDGEQESSPRALVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL21</accession>
    <name>A0A010ZL21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569602.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.352"/>
    <dbReference type="HOGENOM" id="CLU_005831_3_0_11"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="567" mass="61832" checksum="2FEC9A712EC8F139" modified="2014-06-11" version="1">MDPLTLGEAYQASRDPVVRRAFGEHYTPESVVLRTLGPLFLDSLRAASDLDRIAAVRFLDPACGCGNFLVVAYRELRRLELEILSRSGTAPVLPRVRLENLYGIEVDAGAARIASEALRLVERDCNREFSDRFGVEVPPGSPATIVVGNALTLDWASVCAPSSSLFVAGNPPFIGTKERSANQTADLRAVWGPRYSGLLDYVSGWFAKAAAYCESDWAFVATNSIVQGQGVPTLFGAMFDAGWRIDFAHRPFTWPAAAVHCVIVGFTRRPVSTPLNAYLVDGPDVLVTPRRTPLAPDLPPVRAGSKAVDWGYLTVSPTDYAEVAADPIASSFLRRYCGGEELINALDRWCLWFDGAPLDLLYRSPLLATRLNAVRDLRLSSPKAATRAAAVTPHLFHERRQPSVPYLGIPQTFTDNRAYATAAYLPPEVIASIKLFTAPDPDGFLFALISSAAFLAWQKTVGGRMKSDPSFTNTVVWNTLPLPPVPPEARHRVTAAGKGVLSARKPNASLASQYAPDTISARLLCAHQKLDALVDHLFGVTEPNDRARQAALLTRYAELTARRSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL56</accession>
    <name>A0A010ZL56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847984.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.402"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="25095" checksum="9225FB6070837251" modified="2014-06-11" version="1">MRVLVVEDEVRLAGALKRGLQAEGFVVDVAHDGQDGLERTRQNEYDAVVLDVMLPRLSGYRVVQALRADRNWVPVLMLSAKDGEYDQADGLDAGADDYLTKPFSYVVLVARLRALLRRGAPERPVALSAGDLVLDPASKRVTRGEVEITLTAREFALLEYLMRHAGEVVSKVELLEHVWDLYDTGEANVVEVYIGYLRRKIDQPFDRRAVTTVRGAGYRLEPDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM32</accession>
    <name>A0A010ZM32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848490.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.750"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_5_11"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="35232" checksum="869353FF8F07AD0E" modified="2014-06-11" version="1">MDEVTVDVLIIGAGPVGLYGAYYAGFRGMSVAVIDSLPEVGGQLAALYPEKNIYDVAGFPAVRGQDLVDALLEQAQQSKPTFLLEQRATTVDIHDDGVTVTTEPSTPGEPGVTVHARAVLIAGGMGTFEPKELPAGGDFAGRGLRYFVPRLADLTGHDVVVVGGGDSAVDWALALEPLANSVALVHRRDAFRAHEKSVAQLQESSVELVTPYEVTEVHGGDAVERVTLEHVETKETVSRDVKTVVAAIGFLTDLGPMAEWGMDLKRRRILVDRTQRTNLPRVFAAGDIAMYEGKVALISVGFGEAATAINHIAPLVNTKWKTTPGHSSDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMF8</accession>
    <name>A0A010ZMF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.878"/>
    <dbReference type="HOGENOM" id="CLU_112005_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21190" checksum="386C3038A972094F" modified="2014-06-11" version="1">MPMTTIKSLVIEAADPTTATAFYQAIGLADRVRIRHDTTPTTGFRGCTVSLVVSQPATVDALTEAAMSAGATALKPVTKSFWGYGGVVRAPDGTIVKIASSSKKNTGPATKHIDDVVLLLGAENVATTKKFYLDRGLTVKRGFGNKYVEFESSGVKFALYGRRALAKDAGVPTTGSGSHRLAIAADEGDFSDPDGFAWESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMH2</accession>
    <name>A0A010ZMH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.902"/>
    <dbReference type="HOGENOM" id="CLU_058045_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="32688" checksum="E5DE2FC571AB6390" modified="2014-06-11" version="1">MAERLPSVWLTGQQQSRAQRRGRYLPESMAHPGKMLPAIAARAIATYTEPGDLVCDPMCGIGTTLVEAAHLGRYGVGVEFEQRWAELAAANLALASAQGAPGSGQVWCADARDLPAPLPDSHLGQVSLVLTSPPYGPSTHGHARSPGPRRGKVGKINNRYATTPGQRSNLADRTPDELAEGFTRILTGARALLRPGGHAVITARPYRHAGELVDIPGMVITAGQQAGLELVDRCVALIAGLRDGVLITRGSFFQLHNIRQAHAAGDLHWLIGHEDAIVLRNSRVDINAPALTSTVAAPLPGLEVRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN23</accession>
    <name>A0A010ZN23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569792.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1130"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="722" mass="78067" checksum="4010E20550956619" modified="2014-06-11" version="1">MSDARRRFVISHVGRDRPWAEWIAARLADAGAPGSVEVRLAGWRWDTGQPLTEALRSCFLDAEAPVERAVLLFSASLLEASEYVDDTKADLSLLGKVVPVRVEPVALPEPWSGVSGPTLYDAPPAAAADRVVAAVLGRSAAPAPPRLPGYRPDVWNVPARDGVFVGRDDALIGLRTALSADGRVAVEGRFGMGGVGKTRLALEYAHRFGADYDLVWWIPADRPVLVGDQFAALAVRLGLVGPATDTGTAATVARTYLRRNTKWLVVFDNAESAEALAPWLPGGDGHTIITSRTSGWAPVASTLEVDLFSRAESIQLLRSHDPGLSGMEAGRLAPVLGDLPLAAVLAAGYLVETDTRPGDYLTELAQHVAHVLDEQRSVNYPHALAGAISTVTSWLANRDPVALALVRVCAFLAPRPIPVGLLGLADPNLSDEVDRWFRTHPLAALEGIADGSGLLERSVDRLQRLGLVHVERRSQFGIAIEDPLNGAHGVVALHRLVAALLRDQLGADRREAVRAHVDGLLAAADPGDPTDPRRWPAWAQLLPHLYAADPAHSDHSGLRASAVSAARVLLSRGDVRSARDLADQLHRRWRDRLGPDDEDTLRAARCLAQTLRTLGRFEAAQELDADRLRRRREALGEDHSDSLSAATDLADDAWGLGDVGLARRLDEEILARRRRVLGESHPSAIESARRLARDLAALGEAKRAEELRTWVEHTETTRRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN82</accession>
    <name>A0A010ZN82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848931.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1189"/>
    <dbReference type="HOGENOM" id="CLU_101331_0_0_11"/>
    <dbReference type="OrthoDB" id="1721242at2"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="18390" checksum="9077C5C107A5DFDF" modified="2014-06-11" version="1">MTTRSEPARRAPAWWPAARSWLPLAARLILGGVWLWAGGAKATDLAASVRAVRAYQLLPDGLATVVGAGLPWLEIVLGLLLITGVAVRFGSIFSAALLVVFLIGIVSAAARGLRIDCGCFGSGGELDPDQSTAYTLEILRDSALLLVALALARWPRGRLAVDNWISGSWEDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPE6</accession>
    <name>A0A010ZPE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.115"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31025" checksum="9EAD57B7FCD6B14C" modified="2014-06-11" version="1">MSTVTIAVFGATGNQGGAVVDALLDHEARVRALVRDPQSDRAQALAARGVELAVVRADDPASLAAALTAVEGFYFMTPEANSLEEIEVEIRIGTALVDAAADASVPHVVFNSVFGADRETGVPHHDSKHWVEEYLRKSGLRATMVRPTAFMENFTSVMAPSLEHGEIVLRLPLPEDVALKMISIRDIGRVAAALLLGTAEAPGGAVELVGDELTGPRIAAAFGARAGLPARYEALPLSVLPNEFDQAMFRQFAEAAEHPSDLAVVRSIEPATLDLAEWIRATSWTAPTNAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPG7</accession>
    <name>A0A010ZPG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569918.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1629"/>
    <dbReference type="HOGENOM" id="CLU_028458_3_3_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="33964" checksum="04CEE9E3CD1B04C6" modified="2014-06-11" version="1">MRIVRRNTASGPQLAVVDRGDLVDLPGERDLIPLLDGRLAAVAEAALRERATVTAEADAELLAPLEPTTFRDFSTFPEHTAGIVKLFDPAATVSPEFFEIPTFYFSNPYAITGPTADVPVPPNCVAFDFELEVAAVVGRTGRDLTVDEAADHIAGYVVLNDFSARDVQFHEMTLKLGPAKGKDTATTLGRYFVTADELAPRASGSSFDLRMEVRVNGELVGCDRLDNMAWTFPALAAYASRGTEIRPGDLLGSGTCQGGCLAELWGRHGRDFHAPLAPGDVVETSVELLGGTVNRVVAGVEARPIEPFVTASGFTAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPH6</accession>
    <name>A0A010ZPH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="495" mass="54553" checksum="145C06A0881BF767" modified="2014-06-11" version="1">MARESSEHNPAPRVCAHCGGRLRRDNTNTLCDPCQRSAHTVELLAPVLPLDFWAEPEMRAALADHDLGKVSQLYRARTPIRRQHMVAELVGFSQAHISRIERGLCEIRLDTVLRFVQGLRIPPHLVDPIGAPYLDGSTAPELPTTVPTHAGHEVGDNMRRRSVLKGLTGAAALVGFSLAGDEDEEALANDDFGRVGEAHAAQLEDAPKHLYNLDYRYGGDTLCDQAAAQLRRANKLLNRGQYSEKVGQRLQVATGELGICAGWLAFDAGRQDQARYCYTEALAAARMANDANLEVHALANMSMQAVALDRPREGLHMAQAAQRVAEQISTPTMDSLLAMREARAWAKLNDGPAARRAMVRARDAFEQRSDDEEKPVWIAFFDEVELAGNEGMCELDTGRANKAASFLELARGKQREGMVRNKSLYTVRLAFATLARRDVTRAIEIGEEALGMVVNEVTSTRTLNELRAFRRQLAQVSTSTAARTFMARFDSTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPN3</accession>
    <name>A0A010ZPN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADPH-dependent glutamate synthase beta chain-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849615.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1693"/>
    <dbReference type="HOGENOM" id="CLU_024722_4_0_11"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="363"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="451" mass="49580" checksum="D7B63DEA000AC58D" modified="2014-06-11" version="1">MDRPLRIAVVGAGPAGIYAADHLIKASETATVDIFDRLPTPYGLIRYGVAPDHPRIKEIVTALFRVLDNPRIRFLGNVGYGVDVKADELRRFYDATVVATGAEKDRALDIPGIDRPGSFGAAAFASWYNGHPDVPRDWPLHAEKVAVIGAGNVAVDVARILAKTADELLGTEIPDNVYRRLRESPVTDVHLFSRRGPAQVKFTPQELRELDSSPNVDVIVHPEGIEFDEGSYAAMRATRHVKMCVDILQNWAVREPRGRARRLHLHFLEAPAAVLGEERVEGLRTETQELTGDGWIRGTGRFTDWDVQAVYRAVGYLSEALPDVPFDAASGTIPHRAGRVLDLDGEPVPGLYVTGWIKRGPVGLIGHTKGDAGETITSLLADALPPATERDRDAVLAHLDARDVEYTTWVGWQRLDQHEIALGAPHRRKRVKVVPRDEMIAVSRGPVPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPU1</accession>
    <name>A0A010ZPU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847745.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.245"/>
    <dbReference type="HOGENOM" id="CLU_009583_14_4_11"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="40703" checksum="A3285647F3113B99" modified="2014-06-11" version="1">MTVRYSFVSTYPPTQCGLATFTASLRAAIPADDAEHRVIRLTDEPRDDSPSEVVADLVAGDPASLRRAAGEINLTDVTIVQHEYGIYGGPDGEEVLALLDAIRVPRILVLHTVPITPTWRQQWVLQSVLDRSETVVLLTDAARDRLASQYQIPPSKLHVIPHGAHQVGPVPTGPRPGRPIILTWGLLGPGKGIEWGIDAMRELRDLDQPPLYLVAGQTHPKVLAHEGEAYRDRLEARVRRNGLKEYVHFDSRYHDTASLSRLITSAEVVLLPYDSPDQITSGVLTEAVAAFLPVVATPFPHAVELLSTGAGQVVPHRDSVAIAAALRVVLTQGAAASRMREAAARTAPTLHWPTVATRYRRLVAETLLPSSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQJ4</accession>
    <name>A0A010ZQJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848174.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.508"/>
    <dbReference type="HOGENOM" id="CLU_079334_0_0_11"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27173" checksum="34478EF1D33F587B" modified="2014-06-11" version="1">MAGVVLVTGAAGLIGTALRTRMARPGRTLRLLDVAPLGDAAPGEEIVRTSITDTDSVVAACAGVDAIVHLAGLAGEAPFEDILAVNVEGTRNVFEGARTHGVSRVVLASSNHAVGFARKAAEPLPADTPFAPDTWYGWSKTAKESMGALYHHRFGIDVVSLRIGTCRVKPSNTRALDTWLSLDDAARLFEASLSTPSPVFTQVWGVSANTRRWWSLAEGEAIGYHPEDDAEVFAAEVTGEPTDLVGGPFTTTPLGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQT0</accession>
    <name>A0A010ZQT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MHYT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695830_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="40540" checksum="FFC1BDCBD7FE56DA" modified="2014-06-11" version="1">MAEVHHFAYGWLVPALAYSVSVLGSLLGLVCMARSRQSRLPAKRYGWLALSAVSIGGTGIWMMHFLAMLGFAVDGSEVRFAVFPTLFSAFLAVVVVGIGLLILGTGELRLWRVLVGGVFAGLGVAGMHYTGMAAIRLDGTVGYDLKYVALSLVIAVVAASAALWFTVVARNLWLVTGAALIMGVAVNGMHYVGMAAAKVTLDDTHSSADGADVTTALPIIAGLAGVIVVVLLYSALSTPIDEEMRSAESRLGLAGGPGADSESFWTPKSTGQPQPSGPGSTTGSWADAPPAGRPQPWTPGTQPSSGPNYAGPNFGGPAPAGSVPGGADLPWRPGAAAPDGSAQWPGGAPAAGPAAAEDSRWAVLRQKPADQQTGNGPWADTGLADAARRRNASDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQY5</accession>
    <name>A0A010ZQY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_0663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.649"/>
    <dbReference type="HOGENOM" id="CLU_595452_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005100729" description="Glucanase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="459" mass="47964" checksum="F6B6DD90DB8B611F" modified="2014-06-11" version="1">MGAAALGSVVVIGGTSLVAANATADPDHSCAAAYTVHRSWSTGFSAEVAVQNTGEEAVKNWSVNWSFKSGQAVVKGWENGDWKQDDGLVTVRANEDSVRLEAGKTLTLRFSGWHPQGDAPTATDFALNGVECGVESDDKKERPTESASPEESSIALPPGLPGRPVPNPTKKPPTSGPLGSLFVDTEGQAVEWVEGNTGDPRAAVIRDRIAEQPQAHWLAANNPGEVGGDVRSYASKAHSRGRVPVLVAYNMTNRDCGGASAGGADSADDYRTWISNFAGGLGSGSSIVVLEPDALGHLTTCLSSDQQQERLDLLRYAGKVIKQASPKARVYYDVGHSAWIAASEAADRARRAGAAEYGDGIALNTSNYNVSSQEVSYGKRILASLGRGQMVVDTSRNGAGPAGGEWCDPAGRKLGRNPTTATGDAKVAAYLWVKRPGESDGCSGAAGQFIPDTAYDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR30</accession>
    <name>A0A010ZR30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848444.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.696"/>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458253" evidence="7">
        <location>
            <begin position="44"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="291"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="729"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="826" mass="82218" checksum="0E083A21282F675C" modified="2014-06-11" version="1">MRNVLLSGLRTRRRRLFGTFLAVLLGVAFLAATLTMTATMTSAIDGFFGEANAGTDVVVRSSTALADGPNAARPPLAGSVLDTVLGVPGVEAAAPVVEGFGQLLGRDGNAIAVNGPRRASSWVADPALNPWKVSQGAAPIAAGDVVVDRAAAKIGDLHVGDRTTLLTPAPEPVRVVGIVTFGDADAFGGTSYVGLTPADARTFLAGGRDQLTSIQVRGTGADLAGKIGAVLPPGVQAITGAAATDETTAAVNDGFLSALRALLGAFAGIALLVAVLSIHNTFAILVAQRTRETALLRAVGAGRGQVLAGVVAEALVIGVVATAAGIAAGYGLAALLKVVFGALGFAAPVDGLVFPLSTIAICVPVGVLATVLAAIGPALRASRVAPLEALRGAAAERVGISRVRVGVGVVLGAAGAPAVVLGSAVVAVGAGAVLVVAGVLALAPLLVRPLSRLPLRGVTAGLALRNARRNPRRTAGSAAALLLGVGIVTLFTVAAGSLKAASATDVETTFRGDFAVTSGARFGNGSLPADLAPALARLPQVETVAAVGGGQAVVDGSGTSVSAADPASLARVLALPDASGAALSSLRPGRIAVADDSGHALGDRVRVRYPDGSVATDEVVAVYGRSQLVEPVLMSAQEWAPHATQALASAVYVELADGVPAADGRDAIVAAARAYGNPTVSDAGELAGLGAEAIGQLLNLVYVLLAIAVVTALLGIANTLSLGVHERTRELGLVRAVGATRRQVRAMVWWESVLIALFSTVVGAALGTALGWALIRITDTGFSMPIVPIVPLVVIVLGGALAGLLAGARPTRTAAGLDVLRAIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR82</accession>
    <name>A0A010ZR82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ring-hydroxylating dioxygenase, large terminal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725657.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.743"/>
    <dbReference type="HOGENOM" id="CLU_026244_4_0_11"/>
    <dbReference type="OrthoDB" id="275867at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="53"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="448" mass="50198" checksum="16FDDB4FB8E84746" modified="2014-06-11" version="1">MTQTMAEGLVDTGHGGLIAQDWNQLTFRVNREAYRSAEVFQAERDRIWNHNWLYLGHETEIPNKNDYKVRTLGGKPLIFVRGGDGVVRAFLNSCPHRGTVVCREEQGNARNFQCFYHAWTFNSSGKLSALPGDDAYAELERFKGTMDLRPVAKLDIHEGFVFVSFDPDVPPLLEHLGEAADVLSMAAEQSASGMTTLPGIQRYGVKGNWKLAVENAMDGYHFAPTHNTFVGYLRETGFPVTDDDQYAHDLGSGHSMLVLTGHNGRLGMIWEPRFGEAEKERTRLNREAMAERLGQERADEIGDASRILFVFPNLLFFDLEALTIRQLEPVAPGRTDVRAWQYVPVDEEPDVRAMRLKTMTSFVGPGGLATPDDIEAYEAVQRGIEASKGDTRGFNDWSDMSRGMERESKGEKGRSIDEGAMRSFWRHWDKSLGKVSDATATEYGSGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRM0</accession>
    <name>A0A010ZRM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899306_0_0_11"/>
    <dbReference type="OrthoDB" id="1654294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043733">
        <property type="entry name" value="DUF5677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18928">
        <property type="entry name" value="DUF5677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="34180" checksum="4947A556BD6183E8" modified="2014-06-11" version="1">MQEDTPLWRPSSGLADGEPDWAALQRAHDENAFMRLAVELLKSTVALAEALVHAASAKPMALHAAVRCGLLVRSCKLSLDLLADACVGHGRQQIGLTRQLLETLANLAYLCADDESGERHRAFLYNSLISEREFLKVIERRQREDGGAELPIERRLRRSIEDTARAAGINLDEIPGRRQIKWPHAQELIELAFGPTSYPSYRVGSDALHGGWFDLIRNHLREVDGGFMPEFQPLPRRPQPLLAAAAYLGLVAGIFLRSLPDAVRVVFERDVSTILGYAVRADHIHEGWLNADTSEESQAAGSSEQQPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRM9</accession>
    <name>A0A010ZRM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_2373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2337"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="312"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG81264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="409" mass="43980" checksum="B88A30ACE2B894EB" modified="2014-06-11" version="1">MSALGIDPVAEPSLRRWMPLALLAAATLIAVADTLILDRGHERLPFIFGVTAFTATWILVCHPSVRDIPSTYLVVRLVLTAVLVGLNPWYGIYAWYGYVEAPNYLPERLVYPATGAFALIASASYIGGYPTTPVLIVVWLLLSAGSFALVWYLSRAVIKSREQEIERAHMLEELTVTNKRLEETLVENRGLQSQLISQAREAGVLDERARLAGEIHDTLAQALTGIIRQLEVADRGGELAPGPRPHLDLVAELARDGLAEARRSLRALRPGQLEGSTLPQAIGDVAQRAGLPVEVDVAGAVRVLPPDQEVVLLRTVQEALTNVTKHAGATRVGVTLTYFEDAVTLDVRDDGVGFEPDTVGMRADGTGLGLTAMRERLARVDGSLVVESAPGEGTALVATLPAASKVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS23</accession>
    <name>A0A010ZS23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2542"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="35657" checksum="9DB98FCF2C2F3C55" modified="2014-06-11" version="1">MTTMTTQSPSPVERPKVARARRYGLNTRYVPVLATLVLFGLMYGIGIANYEGFSDTQVLLNVFIDNAHLLTVAIGMTFVILSGGIDLSVGSVLALGTVIAATLLKAGWNPFVVILIVLVVGALIGLAQGAIIHFFDIQPFIATLAGLFLARGIAQLISTKAVGITDEFWTTTATERIHFGGFRLSPSAVIAIVLAIAAALALAYTRFGRNTYAVGGNAQSAELMGLPVARTRVLVYTLSGLCAALGGVLYSFETPTGNSLTGTGMELDAIAAVVIGGTLLTGGSGFLAGTVLGVLVLGLIQTMITFQGTLSSWWTRIFIAGLLFAFILLQRIVTRREPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS66</accession>
    <name>A0A010ZS66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725664.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1103"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="169" mass="18883" checksum="D3712CB5535C7535" modified="2014-06-11" version="1">MDELRTERLLLRRWRPDDEPAMAAINRHPDVGRYLNRPVDEASVDAFYGLIVGHWETHGFGAWAVEHEGDFVGFAGLAYVPPFLADAGPAPELGWRLDPRKWGMGLATEAATAARDDAFARLELPEVISIIHPLNTRSQRVATKLGLTLDRQIHNPVLGISTDIWRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSC8</accession>
    <name>A0A010ZSC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-glucanase/beta-glucan synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570125.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2668"/>
    <dbReference type="HOGENOM" id="CLU_625167_0_0_11"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459228" evidence="2">
        <location>
            <begin position="28"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="186"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="45286" checksum="520DDA1760C4C9A9" modified="2014-06-11" version="1">MNRRTIGAVTALGLALATLSAPPAASGAPLPSDRGGVRLPSDRGGWPSLSSDRAGALVGAGARTGDARTGDARTGGGRDVALAGRAFPVWSARTAAASGLVLDRLSVPATAESGQAIAATVRLHAKSTPVAVEALTVAVRNSDGANFDFPGVQPATVPPGGYTFATGQRTFPPGDYLVAAAVRIAGVWTALTPPRYLTVRTNPVTFRQEFSGPAGAGPNYGLSTAMWFDDPRGDARYSLDQAKLDGLGRLALTAEPGPVAPRLSMLDRSGNDGAAAWSQQGGYFAARMKLPAGRGLRPAFRTIGADAASVAWPESGGIDIAEVAGERPGLVRQFAHGGTPDLAYGRAHDLPARGAATDWHVYALDWKPGENGHLRWSVDGVVTQELRAAGAGAAWASFRRPHTLALELAIDGPAPQVPATALIDWIRVYRYPIGSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSI3</accession>
    <name>A0A010ZSI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569814.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383001_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="726" mass="76509" checksum="5367404027DC7311" modified="2014-06-11" version="1">MIVDRARIEEALPGYELGAELGRGAFGLVIAARHRQLDRDVAIKVLGRPGDPVEESRFRAEARVLSELDHPHVVRLHDYVEHSGLFLLVMERLSGGGLALDRVRPEYACALGLAVADALEAAHRRRVLHRDVKPDNLLFAGDGTVKVTDFGIAKIIEGTTAASSSFVGSPVYMAPEQAALGRLGPGTDLYSLSVVLYRLLTGRPVFAVDLPPPAMLLAHLSRRPPPMPDVADRVAGVVLRGLAKDIDDRQPTARSYALDLASAAAESFGGDWLARAGLPVRVDEEVRDAARATKAVRSFETTVGRRLPDWPWGLPPTRLDEVLPSAPSTGKRPAATRPPPGRAPDPGPDSVTEELAARAPAAPTSGALVITPAPAWLLRRPTRRARPLAIATALLGAVLAAIVVGLGVSTFDTGPTVVPGPAGVVASGRTLYVSDPARSQVRRFDSGRVSGSGGTVVAGSGRDGFSGDGGRAVDAELSEPGPLAVDGNGNLYIADIGNRRIRKVTVDGRISTVVGGGTRALNSRLHASQVRLTQPFSIAVSSQGVLWVAEQQRNRICRVQPDGTVEAYVGTGQAGFGGDGLYASWALLKAPTAVALNPSGDRLYVADQGNRRIREVRVGSGFIRTYAGDGSDGPFRNNVQATAGGLSSVYTLAATADGTVFLGGTDARLVDPSGFVRPVAALPTISLAVTPNGTVYLVAEQKNTSGDRVHRLYRRSPSGELTRLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSK7</accession>
    <name>A0A010ZSK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="43" mass="5510" checksum="5F4CD2E37E76983A" modified="2014-06-11" version="1">MSGCYDYSYNDYNDYNDYNECKPRRRRHHKKRYNDCWDYNPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZST8</accession>
    <name>A0A010ZST8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851172.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2826"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="24886" checksum="5D93876D0905BAAD" modified="2014-06-11" version="1">MAALDFTGRTVLVTGGTKGIGRVVAETFARAGAAVVVCARNEPDEPAPGLFVKTDVRDPASVDALVDAAVDRFGRLDVLINNAGGSPEADAATVSPRFVEKVVALNLLAPFYVSQAAYRVMRTQETGGSIVNIGSVSATDPQPGTAAYSAAKAGLLTLTKALALEWGPDVRVNHITAGLIRTEAARYTEQTASLIPAGRLAEPADIANACLFLGGELASYVNGADLAVHGGGEVPARYVVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSW0</accession>
    <name>A0A010ZSW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2841"/>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="15447" checksum="426F543FF8CE2D71" modified="2014-06-11" version="1">MIEHDSESLSETFWAVARRLRHLTKETLEPWEITPGQFRALGVLVRHGEMRLSALSEHLRIAPRSTTEVVDGLEERGLVERSADPSDRRATLVATTEEGRSVGAAIMRARRTEGDKMFGVLSADDQAELARILGLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT16</accession>
    <name>A0A010ZT16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569860.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132031_0_0_11"/>
    <dbReference type="OrthoDB" id="2017850at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF1232" evidence="5">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13142" checksum="7F2D59F6B9DFACE0" modified="2014-06-11" version="1">MARTGSGPLRRKTRLAAAAKVAREASRPGSPSIGARIGAVPRMIRASASGQYPGLSRLKLALLGVGVAYVVSPVDAMPELFMTIFGLADDVAVAVYLAGALFAETDNFLEWERMVAPPTINGHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTX4</accession>
    <name>A0A010ZTX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantetheinyl transferase component of siderophore synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075076_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="109"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24369" checksum="FF9FF5890AB47E8F" modified="2014-06-11" version="1">MLTTLAGLLERLTPSTVAAEETFTDRADVRLYPAEEAAIARAVPKRRREFATVRSCARTALTRIGVAPAPIVPGHRGAPAWPAGVVGSMTHCAGYRACAVALAHDVITIGVDAEPAQRLPDGVLDVISLPAERAALAALAQQAPGIAWDRMLFSAKEAVYKAWFPLMRAPLDFSEATVDFDPVGRTFTARLLVPGPATPAGQLTEFSGRWLQARGLVLSAIVVPAPSVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTX7</accession>
    <name>A0A010ZTX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849654.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1716"/>
    <dbReference type="HOGENOM" id="CLU_060077_4_0_11"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="13581" checksum="6C168759A42F50A6" modified="2014-06-11" version="1">MRIGELASKAGVSVRALRYYEEQHLLASERTPSGQRVYAASAVDRVRFIQQLYAAGLPSKAVLEILPCVHTGVVTPELMARLTTERDRIDHQIAELTATRDRLDGVIRTTIAYRDTQQPCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU96</accession>
    <name>A0A010ZU96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851922.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3363"/>
    <dbReference type="HOGENOM" id="CLU_101709_1_0_11"/>
    <dbReference type="OrthoDB" id="1400203at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458411" evidence="1">
        <location>
            <begin position="32"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="17457" checksum="77B45ED7C2406B4C" modified="2014-06-11" version="1">MRTLSRKIAIAAAAAAIVTAGVSTSASPASAAEPPSLQPPNGLKILGQFVVGSGTQTYTCTAGKFSGSSVPEARLFDGANRKVHHFAGPSWQSESDGSLINAAPVASSPVPGSIPELLLEVKTHSGQGLFSTVTHIQRMNTFGGVAPTTACTDGQKISVPYNANYIFWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUC5</accession>
    <name>A0A010ZUC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851956.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3388"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_2_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23611" checksum="0179C3D2B59984BD" modified="2014-06-11" version="1">MSNHGAPAAGARRIPVTVIGDDPLTRAGLIAHLQSGPDIDLRPATPDGDHRPGVAVVATDRVDRAAVGRLRALSSGWKAVLIVAHLREPELLRALDADVFAILLRHDVTPDRLLRAVRASARHDRDLPADAVGHLVDVVVRLRRADPAGRDDERPPTQRELDVLRLIAEGMETREVAAHLSFSERTVKNVLYGVTARYGLRNRTHAVAHVLREGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUN3</accession>
    <name>A0A010ZUN3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ORF">CryarDRAFT_2007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850040.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1972"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_11"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="41502" checksum="6C98CF74B0B6FBCD" modified="2014-06-11" version="1">MKSLDDLLAEGVAGRRVLVRADLNVPLDGQRITDDGRIRAVLPTITALRDAGAKVIVFSHLGRPKGAPDPKYSLEPVAQRLDELLGAPVAFAADTVGPQAQEIVASVADGGVVLLENLRFNAGETSKDDAERKAFATQLSHFAGQNGAYVDDAFGAVHRKHASVHDLAELLPAYAGGLVRRELEVLRTLTGTPERPYVVVLGGSKVSDKLGVIDALLPKVDTLLIGGGMCFTFLAAQGHGVGDSLLEQEMIDTCKRLLSEGGDKIVLPTDVVLADDFSADANTKVVAADKLEDGWKGLDIGPASVELFASKLAGAKTVFWNGPMGVFELAPFAAGTKGVAEAVASVDGLTIVGGGDSAAAVRQLGIDEARFGHISTGGGASLEFLEGKELPGVAVLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUN6</accession>
    <name>A0A010ZUN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850046.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933101_0_0_11"/>
    <dbReference type="OrthoDB" id="2042171at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="29942" checksum="96FE96403F79801E" modified="2014-06-11" version="1">MTTGVIHDLGYQRYTGPRLGRGYAFRTLYAHTVRTAFGLGRGVKAKIFSWAIIGIIAAVAVVMTAIKAQTGEAVMNGPQFVDNMATLVILLLAAVAPELTSRDQQTRALGLYLARPLRRSDYALARLTGAITAIFLVLAGPLLIMFAGGALSTKDGASGVGDAAVDSAQGLAHAALSALVLTSISLLVASLIRRRAIAAAAVVAVFLIALPAVGVAQELGGSEGTTELVSMVSPPTALSYLSVWLYADGKVPYSDDQVVYGPLLLAYAVVVIAACTALLVARYRKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUQ6</accession>
    <name>A0A010ZUQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852226.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_0_11"/>
    <dbReference type="OrthoDB" id="2035522at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="13268" checksum="2F15301350FCA562" modified="2014-06-11" version="1">MPLQATTIMLGVQDLARAKRFYGDGLGCTIDQDQPGFVSFTLGGGPSLALYPWEAAARDAGVPPAGSGFRGVSFHYVVDSGEAVHQVLKDVTEAGGTIVREAVDAPWGCSGYFSDPDGYLWKVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVA1</accession>
    <name>A0A010ZVA1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ORF">CryarDRAFT_2247</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850338.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2211"/>
    <dbReference type="HOGENOM" id="CLU_077094_2_0_11"/>
    <dbReference type="OrthoDB" id="1912405at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="20475" checksum="5356FB3FD18BAF0E" modified="2014-06-11" version="1">MASRAPAAVRQYGAAVRALLLFTVVLGLAYPLLMTGVSQVVFHDQANGSMTAHGSSLLGQSFTDADGNPLKQWFQPRPSAGSYDPLASGASNLGPNAEDQVKAVDERRAAVAEFDGVAPADVAPDALTASGSGLDPHISPEYARQQVNRVADARGLSVDEVRKLVDEHTQGRILGFLGEDRVNVLELNIALDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVZ8</accession>
    <name>A0A010ZVZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane-anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2467"/>
    <dbReference type="HOGENOM" id="CLU_046690_0_0_11"/>
    <dbReference type="OrthoDB" id="1297228at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022215">
        <property type="entry name" value="SteA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12555">
        <property type="entry name" value="TPPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="TPPK_C" evidence="7">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="394" mass="42183" checksum="A22616AB9A651D11" modified="2014-06-11" version="1">MRLPTLRRPRAADGDSATAGPARLDRRTKRLTQRLKPGDVAIIDHVDIDRVAGDALVASGVSAVINAAPSISGRYPNLGPEVIVAAGITLVDAVGQEIFDRVREGQRVRVDGANVYLGDEIVATGQRQDTETVAAAMTEAKAGLSVQLEAFAANTMEYMKRERELLLDGVGVPEIRTQIDGRHCLIVVRGYDYREDLDVLGSYIREFRPVLIGVDGGADALVEAGYTPDLIVGDMDSVSDDVLRCGAEVVVHAYPDGRAPGLARVDRLGVRAVVFPAAATSEDIAMLLADERGATLIVAVGTHATLVEFLDKGRAGMASTFLTRLRVGGKLVDAKGVSRLYRQRMSSMSLFVLIASGLCAMAAALAISTVGRTSLQLLAEQWDNLVFQLQRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWI5</accession>
    <name>A0A010ZWI5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850951.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2661"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_2_11"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="27"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="498" mass="52465" checksum="50ABA18D7A57DBBF" modified="2014-06-11" version="1">MIDLRESAQNALKACGVEDAALTGGLTVRTPLTGVELLSVRETADVDAAVTAAHAAYQQWRTVPAPVRGALVKRLGQLIDEHKDDLATLVTLEAGKIRSEALGEVQEMIDICDFAVGLSRQLYGRTMPSERPGHRLMETWHPLGVVGVISAFNFPVAVWSWNTAVALVCGDAVVWKPSEKTPLTALACSALLDRAIAEASAPADLHRVVIGGREVGEALVDSPLVPLVSATGSTRMGREVGPRVAARFGRTLLELGGNNAAVVTPSADLDLATRAIVFAAAGTAGQRCTTLRRLIVHSSVADTLVEKLVTAYRKLPIGSPLEAGTLVGPLIDAAAWGHMTDALDAARRDGGEVLVGGGRREVDGDGYYAEPAVVRMPAQTDIVRTETFAPILYVLTYETLDEAIALHNDVPQGLSSGIFTRDQQEAERFLAADGSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWRAYMRRATNTVNASGQLLLAQDVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWM5</accession>
    <name>A0A010ZWM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851022.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2702"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_3_11"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="450" mass="47062" checksum="A2D5F6DFF3D42810" modified="2014-06-11" version="1">MSADGPDLVVVGAGGGLFAALRAAERGLSVLVVEASPHYRRGNNTSMCTAMVPGVGTRWQRAAGIEDSVELFVDDVRRKTGGAGDERLARALAEVSAELVEWMADTAGFEMSLMTDMNYPGHSVERCHTIPERHGAALVDRLTRLADASELIDVLVPARVTDVLLDDDGAARAVVAGDEEIPTRAVLLATNGFGADRDLVREHLPEIAAATYHGSETSRGDALRIGTGLGADTAFLDAYQGHAALSAKASTLLGWATIVHGGIMLDATGRRFGRETSGYSEFGPALAARPGATGWIVYDQGVHDECLPFTDFRHCVEAGAELRASSPEELADVTGLPVEGVRSELAEIERLDGKPDRFGRTFTRALRAPYAAVRVLPALFHTQGGLVVDGRARVLRPDGGTIPGLYASGGAAAGISGHGAAGYLAGNGLLPAFGLAYLAADAVADERAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYB4</accession>
    <name>A0A010ZYB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137187_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459279" evidence="1">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15147" checksum="FA735B52802DE041" modified="2014-06-11" version="1">MKRIAFRKTVITSTVALAIAGGMVGVAQPAYAAPDCSTTVNVHVPQYPVHKVVPATGSGSVDCELGYGNQSSAVRALQVSLNYCHGAGLDTDGMYGPATRNAVRNVQRAKGIPVDGRYGPQTRNAMNHAYFWDAGGFQNCGPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYC5</accession>
    <name>A0A010ZYC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripeptidyl-peptidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851866.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3323"/>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458434" evidence="1">
        <location>
            <begin position="26"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="107"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="524" mass="55074" checksum="F46E84404E66F131" modified="2014-06-11" version="1">MNRTTLRRFVVINLSMLLCAVSLLACSPEESESDARSSDVGLGKFYDQTLRWTGCNAFATSKREAELLADPAARCASLTVPLDYDDPGGATASVAVLRVAARKQAQGSLVFNPGGPGGSGVLGGLAVARALAKSPITETFDVVSFDPRGVGATKPAADCYSEDGTTRGDTVFPLLPTNVALTEEDTRAVAERCTEGSGGAKALIQMGSRTTARDMDVLRAALGDDKLTFLGQSYGTRLGAVYAEQFPQRVRAMVLDGAFDPTLGTVDRRLAAYRGFQQAFDAMAAACAAAASCPLGTDPKAWTSTFQAIIQPLRDKPIPALDQELDFDGALGGVMAGLYAPQLWPSVTSGLAQVRQGRGDTLLQLLRDIEGGEADTAVNGNVTEALYAINCMDEQRLTPEEAVRLRIRTYEVAPFMFPGGDPAEAARGARDGCEFWPAQPTLGIPYAQNIAGLPDTLVVSITGDPTTPHTGAISLADTLGSALLTVKGEGHTVVSSGKNTCVERIAADYLINLKLPPTMPTCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYT1</accession>
    <name>A0A010ZYT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725725.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3503"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="22829" checksum="E6BE81D182A476B1" modified="2014-06-11" version="1">MRWAPDTRSRLERAALELFSEQGYTATTVPQITARAGLTTRTFFRYFADKREVLFGGSEVPDMAAALIREAPPELRPMDVIRHVLHQVAAARFDGQRERTAAWRRIINANDSLRDRDARKRADLVLSARTAFVERGESPLSATLHAEVGALVFHVALEEWLTEPEPRPMAETVDDVLTRIDVTIAADESRDVPPGDPVTASDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A009</accession>
    <name>A0A011A009_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protease subunit 2</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_4003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852751.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_10_0_11"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="PTHR46041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="11">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="11">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15359" checksum="9C78F0680CBB0E1C" modified="2014-06-11" version="1">MRAVLTGVAVAGAAAGAGWWVLRRGFVVVAVSGESMLPTFRPGDRVLVRRRPLHRVRRGQVVVLAPPAELRALPGNPPWLIKRAVALPGDPLPAGVGTPAGHRGDRVPPGRFVVLGDNAGHSYDSRRAGAFPAGSLLGVVLRVVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A096</accession>
    <name>A0A011A096_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570704.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4089"/>
    <dbReference type="HOGENOM" id="CLU_367906_0_0_11"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="757" mass="78100" checksum="7FD89840ECA256D7" modified="2014-06-11" version="1">MTALAVDYGTSNTVAMLAWPDGRIRPLLFDGSPLLPSGVGLEPDGQLLSGRAAQRAGRVSPQSYEPNPKRRIDELELLLGGRDVPVVTAIAATLNRVWQEVRRTLPEPPERIVITCPVAWGPARREVLLAAAGQAGLPEVAVLAEPVAAATYYATEFAGRLPPDGCLVVYDLGAGTFDVSVVRPTSEPLAYRGLDTFGSLDLDALVVSIASDVIGDGFAPLRAPRTVTEQRAFRRLWSDASEAKEALSSRSSATLVVPLLERDVLISREQFEFAARPRLADTIDVTLQCVREARVPVDQVSGVFLVGGGSRMPLIGTLLHRATGIAPTVLDQPELVVAEGALRWVVAEGTPGRAVPVAPPLLDLGPLPEPPPYPAEGGGDGGSAPAGSVTGAAGGAAPAGPYGPSRPSGSLQPSGSSRPSGPTRPSEPSGSSRPSEPSGSTRPSEPSGSSRPSEPSRPSGPSSRPSGPSRPSGPSGPFRPSGPSAPPGPSEETEAGALEQAAPLSAAEGPGRQGGASAAGPFLPSALPPETFGAGAAGLVLPALISAPVGFVLFVISVPVILQTLSYGDQYTPLTWLALAGGSVPSLLLITWAAYRLARLRRGAGLRVDDLGLTVLTGNPGAERRLRGLGWIVPSPLLLLAALIFQYSWPQRADSVSGLAVLLAVLGLIVGAIISARSILPAGREEVLSWRGIGTVTLTRRGPLRRRTLTVVPANPANPANPAPRYLDARGLPARRLAAALARHSGGRFTGTGPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAL3</accession>
    <name>A0A011AAL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847474.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.74"/>
    <dbReference type="HOGENOM" id="CLU_056890_2_0_11"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="163"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="33510" checksum="EEF618E0B643006D" modified="2014-06-11" version="1">MPVQRTSELTVRAATLADAPAVRSLINEVDLVDTGDAGYSVEEVEGDLRRAADLARDSWLAFDGDRLVAYAVLWPASTGTRLDVEHYVLRDAVPAGIQLLDLLTVRAAQITAGADLHLALTPDSVLAVHALPARGWRNVRRHHVLTRRLTPGAGVPPQLPDGVRIRTAESPADQEVAYRLVQETFAGHFGFESTGYADWRKRMDADHRDWSLSWIASRDGVDVGVLVGHNDREATGWVQNLGTVAAARGSGIATLLLRTAFSEFAQRGRRAIGLGVDTENVNNALRFYTGLGFELQFAADTWRLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABB1</accession>
    <name>A0A011ABB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847819.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626196_0_0_11"/>
    <dbReference type="OrthoDB" id="1648755at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17138" checksum="5E7199D55BBC4C5C" modified="2014-06-11" version="1">MTRFTDQVETVLRASGWAPGHRDVQRARHWGLTLSAWASPAGHQHTFSPKASVALAEFGGLTVHQDGPGVDVARTTFTLDPELALPTWLTLRGLGAALNVGLFPLGVEDDGVSTLAIDTTGRVFALDHTAEWLLGRTIEEALTTLVLGRAPRRVHADGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABH5</accession>
    <name>A0A011ABH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569609.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.385"/>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_11"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="192" mass="20890" checksum="38ADFF08D8726AB5" modified="2014-06-11" version="1">MTSPESDGPYAADIERVVVSAADIQEKIAELARKVEADYQADTDSPLLLVGVLKGAFVFMADFARELRHPAEVEFMAVSSYGSSTTSSGVVRILKDLDRDIAGRHVLVVEDIIDSGLTLSWLLRNLASRNPASVRVVALLRKPDAVKVPVEVAHVGFDIPNEFVVGYGLDYDERYRGLPFVGVLKPEVYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC63</accession>
    <name>A0A011AC63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569682.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.658"/>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="721" mass="74359" checksum="77121873F393F8F6" modified="2014-06-11" version="1">MSRFLYRVGGAAAAHPWRTVAVWLTALVAALAVAGIAGGTTHDNYHVAGTPSQRGIDLLERAFPSVSGTDARVVVHGDDLDPALLSTLSQRLTALDHVGTVSPPRLSADGDTALFSLTYTVPVTDFQGTEGVDALEDAAKPALDRGLQVEFGGQVAENIGAISGVAEAIGVVAALVILLLAFRSVVAAGLPIAVALVGLGIGSATITLLAAVTDVSTTAPTVASMVGLGVGIDYALLLVTRYNEGVRAGLEPRVAAATATATAGVSVVVAGATVLLSLFGLTFAGLPIYRSFGSATALVVAVVVIAAITLVPALCALSGRRALPRSHRHDQNHAAPSTTARTASAGEPVTPTAVTARWAARVGRRPLPWALVALAVLVALAAPMLGMRTWPQDAGSQPTSNTTRQAYDLIAAEYGAGANGPLLVAVDLTKVPASSLGALTARLATDPGVALVSPPVTAPSGRAAVITVEPKYGPQDERASELVDHLRADVLPAGVEITGITAVFRDISALLSERLWYVVGVVVALSLVFLLVMFRSVVVPLKAAAMNLLSIAAAYGVMTVVFQWGWGAELLGLPHAVPVSTWVPLLMFAVLFGLSMDYEVFLLSRIREDWLRTGDAHGSVVRGLASTGRVITGAALIMVAVFIGFGLDTDVTVKMVGVGMAVAIAVDATIVRMILVPATMALLGRANWWLPSWLDRVLPPVAPHAEPVEPPVAPEPEPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACA2</accession>
    <name>A0A011ACA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848450.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.700"/>
    <dbReference type="HOGENOM" id="CLU_036590_8_2_11"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="152" mass="16565" checksum="46D3287B964C1B5C" modified="2014-06-11" version="1">MGIDPTEPDLHWLRQAIELSRRCTPSTSAFSVGAMIVDVDGTLVADGWSRRDDPHEHAEESALTRAGTDPRLATATIYSSLEPCSARASRSRTCTELILDSGLRRVVFAWREPEIFVDCEGAERLRAAGLTVVEVPSLAPLVRKVNAHLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACF7</accession>
    <name>A0A011ACF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848488.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_3_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="28235" checksum="59CE3A8CF6E994BE" modified="2014-06-11" version="1">METLVTRYGIARVEGDELAVVDLPYPDLSALLAAGATLAEVDGAAVTRRLPKADLDEVALAPLSLRTTSVWGVGLNYHGKAALTGRPVPTSPILFLKPTTALSGHRDALAIPAGLTEQFDYEAEVGIVIGRALADVSPAEVLGSVAGIIAANDTTARDVMKATGAPVLAKGFPGCAPLGATVLPWGEIPDPNAIPVASWVDGEQRQSSTTADLIFDVADLVSRLSRYARLEPGDVVLTGTPPGTGQDRNEFLRAGQQVTIAVGGLTPLVNTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE56</accession>
    <name>A0A011AE56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1354"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="17690" checksum="E176319BCBAA85C4" modified="2014-06-11" version="1">MVIMDLHLGGDSGVETTRELIRRWPDLRVLVVTMLEDDESVVASVRAGARGYLLKGATPAEVERAVRAVANGEVILGPQVAARAISYLSGARTAGPVPFPELTDREREVLDLVARGYDNTTISRRLVLSPKTVRNHVANMLTKLGVPSRAEALLLARERGLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEA6</accession>
    <name>A0A011AEA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1418"/>
    <dbReference type="HOGENOM" id="CLU_085376_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="22127" checksum="5C71889F48B39B78" modified="2014-06-11" version="1">MTTARDDARPAIALLVGERVRSLRTGRRWSLDELAGRSGVSKGMLVQIEAGRTNPSIGTLVRIADAFGVTVARLVEEARPPEVQITGPDDYSVLWEGPSGGRATLFAGVDDPEFVEFWEWVLEPGEEHVSEDHSVGTREIAHVVAGTMTLVVGDLELRVATGRTAVYPGDVPHRYRNDGDTAARVHMVVTMPPGEFDRRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEH1</accession>
    <name>A0A011AEH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569884.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_0_11"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="444" mass="47790" checksum="858B8B104548E455" modified="2014-06-11" version="1">MPPTGEATAACERVIRTLQAEERVPAVAAAVVRSDRPGWSFALGDAGAGTPAGPATQFRIGSVTKTFTAVLVLQLRDSGMLDLDDQIDAHLALPAHGQLTIRSILNHTSGLQREPWGNLWDTLDVPDDTRLLEEVAKAEAVLSPRRRWHYSNLGFALLGHLVSAKTGAAWAEVLQDRLLDPLGLSDTTVLPRGDAAQGYLVDAYSDHARPEPHFDLRGAAAAAQLWSTAGDMARWALFLAKPDPAVVARSTLEEMYEPVVVTDPVNWHTGWGLGLQVAPQGSGSDRAVDIGHNGAMPGFLAGVWCRRGVEIGAAVLGSSGTAAGITSAPHKLIAESLRLDPVRVEPWTIGGPAPREYAGILGRWWSEGSEFVFRWTKGHLEARSASAVAAAPPAIFAFEAPDLFRTVSGREAGERLEVFRGPDGAVDYMRWATYRFTRDQQTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFI4</accession>
    <name>A0A011AFI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1818"/>
    <dbReference type="HOGENOM" id="CLU_057759_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="30852" checksum="40D874115282A0AF" modified="2014-06-11" version="1">MGNLLAVSDLHVGYKENRDVVRSLRPLAEDDWLIVAGDVAERLEHVAWTLKVLTLSFAKVIWVPGNHELWTSPKDPGSPRGALKYDMLVEACRALGVTTPEDPYPTFDGGAEPVTIAPLFTFYDYSFRPEGQTQEQALAQAYDVGVVCTDEAVLHPDPYGTRGDWCRARVESTAARLDAELPPDQRTVLISHWPLHPAPTKRLRYPEFAQWCGTTLTSDWHLRYRAAVAVYGHLHIPLSDVVDGVPFEEVSLGYPREWRPRSRPHGLPRVVLPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGX1</accession>
    <name>A0A011AGX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide arylation enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850487.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2309"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="541" mass="58437" checksum="6397CDAA0692BEC0" modified="2014-06-11" version="1">MSSTDELVRYPAEVGARYRAAGAWGTRSLAAEFRAVADRVPDREAVVAPDGRLSYRELDERADRLALGLAELGLRPGGRVVLQIGNRLMSVVAWYGLLKAGLVPICSLPAHREHEISGVNRKTGAVAHLVEAGGRFDLVEFARRQRIGVPLTIGAADGPNRLEDLIDRSDPAAARAAVDRIQAEIHPDDVAVFQLSGGTTGVPKIIPRLHAEYWYNARAYAEASGWDETTRNGHLIPVIHNAGIVCGVHAPHSVGGCTLLTSPALDQALPMLAAEGVTDVLFGHGHYGAVGHPVFPRLVPSLRRVVLSGAKVPLPLFEALEAHGLWAGQLFGMGEGFFALSSAEAPREARLTTVGTPISPLDEFRVLDPSSEDEVPDGEVGELACRGPYTLRGYFDAPDVNKVAFTSDGFYRTGDLVAVRTFGRERALSVEGRIKDVINRGGEKISAEEVEVLLLRHPGIREAAIVAMPDERLGERACAYLVPTEGRLTLPDLQEHLAALGVAKFKWPERLEWVPALPKTAVGKLDKKLLHRQIAAKLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHZ8</accession>
    <name>A0A011AHZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851040.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2716"/>
    <dbReference type="HOGENOM" id="CLU_030571_3_3_11"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="29012" checksum="31927A74A7E16FEE" modified="2014-06-11" version="1">MSERYQLTIVRYGTRQTVRSEVYLNHHLYAEPDGPIGMDYFFWVLRNSARTVVVDTGFSAAGGARRNRTTLVEPVAAFDALGVDRGAGPPVVITHAHYDHIGNLDLFPASPLTIAAAEYAFWTGPHAGRTLVHHSVEDAEIDRLRQAGAEGRLRPFTDSVVVAPGVLVTRVGGHTPGQSVVTAETSDGVVLLASDSVHYYEEYQRDMPFTQVADVVAMYDAFARIRGQLASGAVRHLVTGHDPDTLRRFTPVTGGVLAGLAATIGEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI77</accession>
    <name>A0A011AI77_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570155.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2777"/>
    <dbReference type="HOGENOM" id="CLU_023081_0_1_11"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="46999" checksum="69E338AED9470EF4" modified="2014-06-11" version="1">MTVLPSGGDQPSLHEGAGGWDDHRPPDPELIKDCVHCGFCLTTCPSYTVFQDEADSPRGRIVLMRVGHEDAVGPTTQNHFDRCLGCMACVTACPSGVQYDRLIEQVRPQLERNVPRTPADRAFRALVFGIFTHPGRVRALIPALAVPGKLGARLGRLLPAGSRLRALMSLAPPVRLSATVHQLPRVTPAAPGVEPRGTIAFLQGCIQRALFGDVNAATVRVLAAEGFEVHAPRTPRCCGALQLHGGVEESALVEARKVIAAYEGYDTIAVNVAGCGSAMKDYGHLFSDDPEWATRAAAFSAKVRDVHEVLGAVEPQARRHPLPMRVAYHDACHLAHAQGVRTQPRDLLRAIPELTLVEPAEWEICCGSAGIYNLTQPAAAAELGERKAANLAATNADVIAAANPGCALQIAAHLENPIPVYHPMILLDASLRRLRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIY0</accession>
    <name>A0A011AIY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3063"/>
    <dbReference type="HOGENOM" id="CLU_375413_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="739" mass="80988" checksum="DDBFC2A0315E21F2" modified="2014-06-11" version="1">MTVRIVERETSRTAFARHLDATLALENRLMLDRKLRDEVRGHVLDHYDEVLRACAETIEHVKRTPSAISFASFIRAFPFWAGPPAGLVLWYMLHNKLSTLLRSPTLSWPFVTIMLWELLGVTVLVWWIRSARRTDLQVRISLVDALKEQLKSAANLAITELMEAEERWANTFVAVKAPRLVEVEDLYVVSSSSYDRAFRFVTGHTASAVGIVGARGAGKSTLMRHLIANPKFECIGAHVVAPIHYSESEIVRLIHWKLTEALLSATSNNAKLGRRKSSGIDQLRLAPTLHDKILPASRWLLFIGVAAGLTLLWVGDQQNLSTLPDYGDAAHEVLAARSVGYTGLTALAGLGVLAGLLIAKIWRAFQAGARLRSSPRTLAGLAHQQLDWLKWTVNLEGTTKKSLKIGSVGLEGQGKLSRAERALTHADSVHALRHFMYRISQITRRKTPVIICVDELDKLNKGSDAVKVVNGLKDLFHVAGVHFLVSVSNDALLRFATRGVPLRDVFDSSFDTLIELKPLTFAESRDLIARRASDVPASAVLFCHAWSGGNARDLIRAARSCVQVLEEESLGDTTSELRLATVVDRVLTADLNEVLSAVLQRLRHKPAADDSFTEILAFKELLASGDGTLAEVLSAALTKSSLPGPSTGGSEAQLLASAIDPYMRIAALLATLFEADRSPRDWQSESMIVAVTEVAAARSGLGRHPAEIQRSINRAVKSCASIVGQSAVDQFSLRNSRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIZ8</accession>
    <name>A0A011AIZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090714_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="24317" checksum="438E725E36A08356" modified="2014-06-11" version="1">MSAELADELARKREAESKAEQARQLVARYRDPLLLSSSDLQSRIFNVLRPNGFRGGRHPEYFRMNTLYVIAEFFGWLEVIRRDLQFLDLGAAEDTRLLLERIEGVRHAFASTSAWRDDYYIYRGEQRAIGELMAVATNSAEQASGAVCLGYASFVQKLDDPGFGRWFDRLGAAVDALPGKRPERLVHAQNALIDLIEFLDPDGHRLTGQRERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK38</accession>
    <name>A0A011AK38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852044.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524516_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="519" mass="55272" checksum="58D57CD5491FAA28" modified="2014-06-11" version="1">MASDYEDPPTRTGSGEPAFPKAVRPEPPIAGETVWFVGPPEEPDRFEVSGPPTAGSEGVTWRARYTGRLNSPLAIAVKQLNRPPGAGLDWPSPAEFSRWQDHRILLQSMLAPHLVSVIDVFLGSPPHPADAEESPGLIPYVVMPWIEGPSLARYVEGSRATVRSLSERLALVRDLAEALGSLHAITRAGGNVLTHRDIKPGNCIVTPDRGLVLVDLGTLRLTEDGFDDLGMHTPEYAAPEVLADPRASRGKPSDVYSLGAVAYFALVGADPPAADRGDVTGVHLRSVAASARIPDPEAFADHLLTAMHSDPAVRPTDPVNWANELVRRGTPSGAPATRMLPAALVAVLVAVLCAVALVWGQSIGGRSSTPAVGTPPTVGFTPPIPTRYGVQIVEPAPAQRVQRCAVFRGRSALPAGKTMVLAMRNRTNGEPVRYLVEVDGWDRPSRLATWRGKQFFGTADSSVGQEYTVEVLVVDLGAVTRSMRAAHAAGELWTLETLPATWEVAAAVTVRRIAGPGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKG3</accession>
    <name>A0A011AKG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852265.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3612"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_11"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="35286" checksum="7A9F72CB0C6C3D22" modified="2014-06-11" version="1">MSVRIGINGFGRVGRCFYRIARARGLDVVAVNDLTAPATLAHLLTYDSTFGRLDTEAVVTDDGIAVGDSRFAVTAERDPAALDWGAYGVDLVIESTGRFRARDDAAVHLKSGPKKVLISAPGKNADATVVLGVNEETYDPGRHDVVSNASCTTNCVAPMAKVLNDAFGVERGLMTTIHAYTNDQSLLDAPHKDLRRARSAASSMIPTSTGAAKAVGLVVPELAGKLGGVAVRVPIEDGSLTDLTVQLRRDVTADEVNRAFADAAVGRLNGYLRYSTAPIVSRDIVGDPASCVFDAPLTQADGPLVKVFGWYDNEWGYSARLVDLAEYVAARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL66</accession>
    <name>A0A011AL66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
            <ecNumber evidence="3">4.2.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.83" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852629.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3860"/>
    <dbReference type="HOGENOM" id="CLU_813586_0_0_11"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047584">
        <property type="term" value="F:4-oxalmesaconate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="37802" checksum="3C4A414333180533" modified="2014-06-11" version="1">MIIDCHGHYTTAPAAHTSWREAQHAAFGTGRRPPPYPTITDDEIRDSIEGSQLRLMAERGIDLTLFSPRASAMGHHVGDETVSTGWARVSNDLIARVVALYPERFAGVAQLPQSPGVPIVNSVAELRRCVLELGFVGCNLNPDPSGGHWTSPPLTDRSWYPFYEAMVELDVPAMVHVSAVTNPNFHATGSHYLNADTTAFMQFLTSDLFTDLPGLRFVVPHGGGAVPYHWGRFRGLADMLGRPAPAESVLGNVFFDTCVYHQPGIDLLFGVIDVPNILFGSEAVGAVRGIDRETGRYFDDTRRYVDAVPLTEHDRRLVYEGNARRVYPRLDAALRARPVPELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM14</accession>
    <name>A0A011AM14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853207.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4187"/>
    <dbReference type="HOGENOM" id="CLU_051715_3_1_11"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="29262" checksum="E2CDE4484DCFA258" modified="2014-06-11" version="1">MSTIVLIHGLWMTPRSWEAWVPYLEAKGHRVLTPAYPGFEVEVEALRENTDVIANLTVPETVDHLAGVIAALDEPPILIGHSFGGTLTQLLLARGLGSAAVVIDSAPTEGVHVTPLSQVRSLFPTLSNPATYHRAVGFTPEQFHYAFANTLPREESDRAFERYAIPAPGNWIWAYGLLANLKPGHQETWVDYSNDDRAPLLFIGGGSDHIMPPSVNKSNAKHYEKSSALTEYHEFEGRSHWTCAEPGWEAVADHALDWALKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGE8</accession>
    <name>A0A010YGE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.323"/>
    <dbReference type="HOGENOM" id="CLU_035411_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="413" mass="43729" checksum="C35520DB92CBAABF" modified="2014-06-11" version="1">MSAATYPPTHGLSGRPVDPADAGPVRVILVEDDHGDAFLVEELLAGARVAFELTWVQNLADATSALDSGVRCVLLDLNLPDATGMEGLTKVLELAPQAAVIVLTGLADEHRGVEAVAAGAEDYLVKGQVDGELLARAIRFAVERKRADSAALRLREAEMLASENARMERALLPTPLLHDDRVHFAHAYRPGRRMALLGGDFFDVIERDGSVFALIGDVSGHGPDEAALGVCLRIAWRTLVLSGVPADGMLPVLDMLVVRERHSPFAFATVCMVVISPDRGSADMYLAGHPSPILVSEPGLVAGGVGQLPMGPRGPALGFLPEGHWPAVPVPLPPSWALLLFTDGLFEARTGNGPDRLGEEGLVDLIARHHPGFPVGISWPETLLDAVEEQNGGALADDAALVVLSHAAEEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGW5</accession>
    <name>A0A010YGW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2286814_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="10573" checksum="018B724E3A0916F2" modified="2014-06-11" version="1">MPFGSGFGSYAVRVASTDISALSRRPGRWFLRVGAACFVAGLVFVGIVFLPFFAGSSAQPALAAVGTMLGPLGFVLVLVGITRQARANNRAAREALRATRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHE1</accession>
    <name>A0A010YHE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="22633" checksum="06AED6F8E3CE1D10" modified="2014-06-11" version="1">MPVINLDGLTGAQKQGMISQLVVPRPIAMITTTDPDGKLNVAPFSYFMPVCGEPPTIAVTIGTVREATAEPKDTWVNLQHSGEFVVNLTSTALADHIETAAKEFPNGVNEAELIGWDTIPSQVVAPPSLAVSPAHMECRVVEVIDRGDPTSCFSGVHIVLAEVVCIVADEAILAGPNRIDPTKVSPVGRMGFPWFVAAAGEALFEQERIAYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI12</accession>
    <name>A0A010YI12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.956"/>
    <dbReference type="HOGENOM" id="CLU_069356_11_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="22201" checksum="111D8DC18933D015" modified="2014-06-11" version="1">MTGKERREQLLTIARKLFADRGFEATSIEEIATRAHVSKPVVYEHFGGKEGLYAVVVDREMRHLLETITNALSSSHPRILLEQVALALLTYIEDETDGFRILVRDSPVATSAGTFSSLISDIASQAEHILDEEFKRRGYESKLAGIYSQALVGMVALTGQWWLEARKPNKEVVAAHLVNLAWNGLSNLDAKPRLRVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJD9</accession>
    <name>A0A010YJD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dithiol-disulfide isomerase involved in polyketide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849184.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1386"/>
    <dbReference type="HOGENOM" id="CLU_087602_1_0_11"/>
    <dbReference type="OrthoDB" id="996965at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="208" mass="22836" checksum="1DF8A0589A53D597" modified="2014-06-11" version="1">MSEQRTPVDFWFDPLCPWAWMTSRWVLEAAKVRPLDVTFHVMSLAVLNEGRDLEEHYTEMMKKAWGPVRVVIAAEQAHGNEVVLPLYTALGNRIHLQKVELDDPSLLTDALREVGLPESLAEAATSTEYDEALKKSHHAGMDPVGMDVGTPVIHVPGPDGPVAFFGPVVTPAPKGEAAARLWDGAVLVASVPGFYELKRTRTSGPIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJR5</accession>
    <name>A0A010YJR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1532"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="37960" checksum="2DF47A32A7CA4411" modified="2014-06-11" version="1">MTDPTRPPTDPTTTPEPPASASGMGPAPVATVPPADEQARVEAAAADATPAAEAGPLRARLAALSEGGATRNIGLIVVLVILCIVGFATADTFATTGNIRTILTNASVIGVVTVGMTFVIIGGGIDLSVGSIVGLASVWCTTVATQSYGPFVMVLCALLVGLIVGLVNGALIAYGRLVPFIVTLGMLIGARGLAQQIAGLQTQVVKSETFNGIADGAFLGVPYLVWLLLGTFAIGWVVLNLTTFGRRTVAVGGNPEAARLAGIDIRLHTALLYGVSGLCCGLAAVMLTAQTASGSSTNGQNYELDAIAAVIIGGTLLTGGRGTLVGTFLGVLVFTLITNLFILNNLSTPVQNLAKGLIILGAVLLQRRRSESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJV1</accession>
    <name>A0A010YJV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849467.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810544_0_0_11"/>
    <dbReference type="OrthoDB" id="1801605at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="32021" checksum="296BBEEE3C0A567B" modified="2014-06-11" version="1">MVLIFLAGEALIRVYWLLGGRWGYTACDRTHVVHPSDGCGAAQVAELPFWSGWGALGLCVLLAGVVLWKPPAVVLWTVAAGLATAAFPLHLLFEIPAGLAGRPTDWRDVTARLALLAGAVLFARLAPRPARGPSAYRPVAPWVRRSAYVAVAIPLVGWALPHALWALDVPFGISGAELDDIQRNLSLGSALAITAVPPVAGLLALGLAQRWGQQFPRWVPVVGDRSVPRLLALVPAGAVAIALIAYGGLSTGVLVRSLLDGSRNWSDVVDGWAVVLTLVVFVGWGAALAVTAVGYHRATRAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKD8</accession>
    <name>A0A010YKD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849724.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1756"/>
    <dbReference type="HOGENOM" id="CLU_111152_0_2_11"/>
    <dbReference type="OrthoDB" id="2075110at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17643" checksum="04B87D06FAC0E033" modified="2014-06-11" version="1">MLFRNITLVAATTASGLAAGLFYSFAIAVMPGLRQADDRSFVDAMQRINVAILNGWFAFSFGGALLLTVLAAVVEWRAGTRAVALWIAVAVVLYVATLLITFAINVPLNDQLDRAGDPARITDLHAVRAAFETSWVRWNVVRAVLSTASFVTLVYALIKRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKV0</accession>
    <name>A0A010YKV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ORF">CryarDRAFT_1950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1914"/>
    <dbReference type="HOGENOM" id="CLU_047382_2_0_11"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="43085" checksum="CDDF0FACC891E139" modified="2014-06-11" version="1">MSTDLGLPALTAQGFAEPSPTAAALLLLGRGTDPDSERGVDCPGDLPAASDPGLVERATKAREQLGDRAFVLGHHYQRDEVIQFADVTGDSFKLARDAAARPDAEYIVFCGVHFMAESADILTRPDQQVILPDLAAGCSMADMAGDQQVHEAWEVLKDAGVADATVPVSYMNSSAAIKAFTGRHGGTICTSSNAKKALDWAFTQGEKVLFLPDQHLGRNTAVLELGQSLDDCVLFDPHKPGGGLTPQQLRDASMILWRGHCSVHGRFSLDSVLDVRDRIPGVNVLVHPECRHEVVTAADYVGSTEYIIKMLDAAPAGSSWAIGTELNLVRRLALAHPDKTIVFLDRTVCFCSTMNRIDLPHLVWSLESLARGEVVNRITVDSETAHFARVALDQMLALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKX7</accession>
    <name>A0A010YKX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850011.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9acto-a0a010ykx7">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1949"/>
    <dbReference type="HOGENOM" id="CLU_076594_0_1_11"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="4">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27388" checksum="3193B15BB5E6EAEF" modified="2014-06-11" version="1">MSVLPGAEPFLLDAGPDAPAAVLLSHGFTGTPQSIRPWGEALHAAGYTVSCPLLPGHGTRWPDMNRTTWHDWYKAVEDEYLSLHSRGVPVVAGGLSMGGTLVTRLAEVHAGKATEPAGLLLVNPSYLTLRKDAALLPVVSRVLGSFPGISDDIKKPGAHELAYDRLPLKAAASLSQLWKVVRADLGRVTVPVRLYRSAEDHVVEPASGEALLAGVSSAVKSEVVLRESYHVATLDNDAPTIFAGSAEFVASLLSPAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL01</accession>
    <name>A0A010YL01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850043.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099045_0_0_11"/>
    <dbReference type="OrthoDB" id="1833903at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="24549" checksum="CCDF2399F4568E94" modified="2014-06-11" version="1">MAVAGVIARITTRGLLGRRRFFLLLPLPLLLIGATLIGRASGVSPDRWADPVLTQVGFAVVLPLIAMIVGTGVLGSELEDGSAVTILTTPVSRGTIVLTKLAVAIGITTLATAVPMFIAGVIVDSARLGVGLAVGAFVGTVAYSTLFVALSVVSRRPVLIALGYLVIWEGTLVSILSGVRWLSIRQFAVAVGDRVASTDLVTANLSALYAVLATAVLAVAATTLAIDRLSAYSVRGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLT2</accession>
    <name>A0A010YLT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850386.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2253"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_11"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="31696" checksum="C79F8F8B22AADFEE" modified="2014-06-11" version="1">MTWTERDIPDQTGRVAVVTGANTGLGYETARALAERGASVVLAVRDTAKGAQAAARIHGDVTVQALDLSSLESVRTAADSLRSAYPRIDLLINNAGVMYTPKQTTRDGFELQFGTNHLGHFAFTGLLLDRLLPVPGSRVVTVSSVGHRIRAAIHFDDLQWEHSYGRAAAYGQSKLANLMFTYELQRRLATHGTTAAVAAHPGMSSTELLRNSPALFRGTLTLLAPVVTQKPPQGALPSLRAAADPAVLGGQYYGPDGVGEVRGAPHLVTSSPQSYDVALQQRLWSVSEDLTGVTFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMR7</accession>
    <name>A0A010YMR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2595"/>
    <dbReference type="HOGENOM" id="CLU_032690_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="29632" checksum="0AAB861F77A2A1C8" modified="2014-06-11" version="1">MRVVTQTTTGAPTILDLFALDELEPGLYRAGTVFDEDFPLYGGQVAAQALRAAGLTVPDGRSPHSLHGYFLRGGDAGRPTDFRVEQDRDGRSYSARRVVAAQDGEVIFTMSCSFHVVEDGADRDVVPAPDVPHPSTLRTGPMPRMFSMLGALPPAPHPGSEWPTRWWARCVADLPSDALTHACVLTYLSDISTGLAPYHDESSSSGSSLDHALWFHRPIPLDEWVLMDLQGHSTAHGRGFYTGTIRSADGVLGATIAQEALFRSRERSIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNE7</accession>
    <name>A0A010YNE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851128.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2781"/>
    <dbReference type="HOGENOM" id="CLU_021377_8_1_11"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="40698" checksum="67966DB6A3A7C7CD" modified="2014-06-11" version="1">MITIMVVGAGYAGLAAVTSLAGRLRGRDDVHVALVDASDRFTERLRLHQVASGQHPAEFRIPELLAGTGVEFVRARVTGLDAAARTVRLDDERELRYDTLVYALGAVADTDAVPGAADHAETLDTLDSATRVATRLAALGTGRVVVCGSGLTGVEAAAEIAESHPALRVTLLGRDAPGSTLGPKARAHLTAALARLGVRVRTGVIRAVHPHAVQLDDGEPEPADLVLWTSGVRVAPLAAKAGLDVDERNRIVTDATLRSVSHPEIYAVGDAAAVRQTFGTLHGTCQSGMPTGVGAAVAIVRALDGRTPKPFRFGYLHVPISLGRHDAVVQFTRPDDSPKRAALTGRSARWYKETVSAAPWPAFGRTLKAPRTAVLGWRRGGRHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP53</accession>
    <name>A0A010YP53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3050"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="34278" checksum="714A8D97E35E91B4" modified="2014-06-11" version="1">MNTFPEPRFVSVNGVELEVFEAGRENAGKPIVLCHGWPEHAYSWRHQMPALAAAGYHVIVPNQRGYGNSSRPAEVTDYDLAHLAGDLVALLDHYGYDDATFVGHDWGAFVVWGLALLHPDRVNGVVALSLPYQERGEMPWVDVLEAVLGPDFYFVHFNRQPGVADAVLDEHPARFLGNLFRTPPRAGATMIDLARDETPTGEPVLSDRELAVFVSAFESTGFTSSINWYRNLDRNWHLLADVDPVVRHPALMVYGDRDTIVRAQRLTDFVPEVEVVSLDCGHWIQQEKPDETNQAILKWLDQRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ90</accession>
    <name>A0A010YQ90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010897_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="28282" checksum="FFF0144A74C86C6B" modified="2014-06-11" version="1">MTQPSDRDAAAWRVTAAAIRAEAAAVPAPGPELFARVAAQLSSPHPATTPNPVVRPIAGYGAATHRLTARPAVAVRLMLAQLRILHRAVWPATALVLALGVTLAAIGPDHRAADLLGLIAPLVGTLALAALPAPGAEPEFAVASGTSPRTVLLARLAVLSTWTAGLAFVASLVLTGDNTLTTLVESWLGPFALLTAVSVVGAVLSRPSVGVAAAVALWGLRCVTRTPGAWEPLARVVDRWWTTNLTVLAVAVTVTAVAVGLAPVNPHRLRNYSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQB9</accession>
    <name>A0A010YQB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, glycerol uptake facilitator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3528"/>
    <dbReference type="HOGENOM" id="CLU_020019_8_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="27333" checksum="26F79558E77A96ED" modified="2014-06-11" version="1">MAADPAPQIRPAPTAGVELSRRLLAEFLGTGLLVTAVIGSGIMAVRLAPGQPGLQLLANSLATVFALAALILMFGPVSGAHFNPVVSAADWWLGRRTGTGLRPSELAVYTAAQVLGAIGGAILANTMFGLPAVTAASHDRTGGPLWLGEIVATTGLLLLIAALTYSHRTALAPAAVAAWIGGAYWFTSSTSFANPAVTIGRAFSDTVAGIAPASVPAFVAAQLLGLVLAVGLVAALYPTGRNIVDDDPFVTHHDDITENRTVLPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV49</accession>
    <name>A0A010YV49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070643_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="29050" checksum="9226548C4FBABD83" modified="2014-06-11" version="1">MHRFRDTTQGGSVRRTGRSQLSEGMRAQHDPLTAGLPWYGWLFDRILVHTPDVAAVLEVGAGAGLLWTYNYDRLPMAWWVWLTDTNPDVVTELRNAVDGAPQVTVTHGDLADLPLGDSAFDTVVANHLLELLDDPMPALGEFGRVLRPGGSIVLAADGPTHLIELDRLLAGRVEGWRPLDVPRFHLGNGALVLAERFAGVRQERFSDGFRLLDADTVMMLLAAVCGRRLSIEHAAEIRAEVAAVIDRDGHFHLTTDTGLFVATAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW12</accession>
    <name>A0A010YW12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847879.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.336"/>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_11"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="487" mass="51256" checksum="E872A847C69BDEDE" modified="2014-06-11" version="1">MLLGIDIGTSSSKGVLVRPDGTLVASATREHGVSTPQPGWVEHDAADVWWADLASLVAELLPAADEVTGVGISGIGPCVLVADADGRPLRPAILYGVDTRATAEITELTERYGAEKILARGGSPLTTQAVGPKLAWLRRHEPATWAATRRLFMASSWLVHELTGEYVLDHHSASQSSPLYDAGTLSWAEDWADDIAPGLERPRLAWPGEVVGRVTARAAARTGLPEGVPVVAGTVDAWAEAVSVGVRDPGDVMLMYGTTMFLVEVLPERRSSERLWGTVGAFPGTYTLAGGMATSGAITGWLRGLTGRSYGDLTEAARDAGPGACGLLMLPYFAGERTPLFDPDARGVLVGLTLRHGPGHLYRAALEGTAFGVRHNLEAMGENAGRRLVAVGGGLRGGLWTQIVSDVLQEPQDLPTYAIGASYGDALLAGLGTGLVTDASGWNPIASVVRPDPEAAAGYDELYRLYRDLYPATRDTAHALAALNARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW40</accession>
    <name>A0A010YW40_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847932.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.372"/>
    <dbReference type="HOGENOM" id="CLU_016297_0_0_11"/>
    <dbReference type="OrthoDB" id="1239213at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="605" mass="65496" checksum="0D4D5EC4843D752F" modified="2014-06-11" version="1">MTKRLVVVGAGPGATGLLERLIASAPGVLEEPLLITFVDPHPPGAGRVWRADQSPLLLMNSMAEDVTMFPDESVQVEGPLAPGPALHEWAGEAGAPDVEGRSFVSRTVQSGYLTWVFDRVRASAPANVRIEVRRDRAIRVEDGPSGQIVHLASRQRLEADVVVLALGHLDARPTGESARLAAYADAHGLTYVPPAYTADLDLSALKPGQDVLVRGLGLAFVDLVVLLTEGRGGRFENGGYVPSGHEPRIHVGSGRGVPYHAKTGYRLVGPPPPLPRHFGQEQIDALPDGPLEFRRDVWPLIAKEIGWGYYHELFAGHPERTALPWDDFAAAYTDAAWYSAARVDLVASAVPAEEDRLDLDRLDRPFTNTTFADDDAVQVALRTYIEADVARRNDAAHSADLGAFLALLSIYGQLPRVLAQKQLTGRSQVEELDGWWHGFFSFLASGPPGFRLDQLLALSRAGVVRFLGPDVRFDGVDGQFRACSPAVPGETEADALVEARLPRPTIAATADELLRDLLATGQGVEEVVDTVSTGRLRTNRSYQVVDDHGREHPRRFALGWYTSSRGAAAFARPRTNAAPFRMADHAARAVLSALRESVGSATDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW80</accession>
    <name>A0A010YW80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848020.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.422"/>
    <dbReference type="HOGENOM" id="CLU_048259_1_2_11"/>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17699" checksum="16E213B6A916D539" modified="2014-06-11" version="1">MTFTVGETVVYPHHGAALIEAIETRTIKGVEKQYLVLKVAQGDLTVRVPAENAEIVGVREVVGEEGLDRVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDRERGLSAGEKRMLAKARDILVGELALAEGTGKDDAELLLDKVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW98</accession>
    <name>A0A010YW98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848055.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160549_0_0_11"/>
    <dbReference type="OrthoDB" id="2006236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458185" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="13701" checksum="26148F8D220E366D" modified="2014-06-11" version="1">MALKGFTQRVLVSAAVIGATIAGSFAMAAPAQADSANGCAYPRVCFYKTGNDWSTDHPTAAYQDFTSGYQTLGSQSRGSYGVYNTRNNDGALLHFTNGQTRCLAPNRFLWAQDVGTVDKIRIMDSASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXY6</accession>
    <name>A0A010YXY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509700_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="534" mass="59933" checksum="7235B0BE148DCDCC" modified="2014-06-11" version="1">MVEPYDRPVARKIELRPTRDPGEKSVDLITQVEYVSTIVLDAIGENQKAAVSNTLIGTMRELRGRSKRFVDRDYAVWYGEVENHGEKFACIGLPERFDADLHIYYQRALRRAGWNIRAIHRYLVSDMDAEPILRWDRGRIIAYKLGLDEATGEFGPDVEERSCEIRSRPTRSNVRTPPAPATFRASEVHSFESWDQLRREIVAYVGHLTAPSSYAGLRRFVTEHCGIGVVEVKNAGIDSFAYGLTQAGWIDDDGCGVRVLIQSALTTAHKHAVLAHELAHYVLHFPILYLRQLIEQASWSDARFESAYTEAYSEAFPNPPDIEADASYFASYLLVPRWVNEEFASLVWEENRSPTAYELAWRFLQPLLAADDGQPGWQSLERVRGESAGEKSVWSDLNAQGLDDLYATMVAALAGRESAHSEQVRDSVVTGMQRLESLLQDRLDGSTMGAVRKRSDGTAAIEGTEISPARRVYPPLAADGRADRRFPIVPVKLTAAGEDDEWASPLAAGVASVHAWRREYEDISVVAYPYQAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY07</accession>
    <name>A0A010YY07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-6-phosphate dehydrogenase (Coenzyme-F420)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860858.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A010YY07"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1129"/>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019944">
        <property type="entry name" value="F420-dep_G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03554">
        <property type="entry name" value="F420_G6P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="36915" checksum="EDC76E36F3510BD2" modified="2014-06-11" version="1">MLKFGYKASAEQFGPRELLDYAVHAEKVGFDSVWVSDHLQPWRHDGGHAPNAIAWLGALGASTERVQMGTSVLTPTFRYHPGLIAQVFATLGLLYPERVILGVGSGESMNEVPLGVEWPDNKERFARLKEAIEIIKLLWSEDRVDYQGQFWSLDKATIYDKPSTPVPLYVAGSGPAATRMAGRIGDGYITTSGKAPELYTDKLLPALNEGAEKAGRDVKNLDLMIEVKVSFDPDRAKALEDTRFWGALALKPEEKSDVEDPIEMQRLADALPTERTASRFIVSDEPEEHVAAIKRYIDLGFTHLVFHAPGPDQARFLDLYGERILPLLRKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYZ3</accession>
    <name>A0A010YYZ3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849327.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1490"/>
    <dbReference type="HOGENOM" id="CLU_038505_1_2_11"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="30828" checksum="234BD9DCEF5B14A9" modified="2014-06-11" version="1">MSKRREPVRPPTPHVSGARPPAIPADLVPKHVALIMDGNGRWAKQRGLPRTEGHKRGEDSLFDVIEGCIEIGVKYLSAYAFSTENWKRSPDEVRFLMGFNRDVIRRRRDQLHAMGVKVRWAGRRPKLWRSVIAELEDAEEMTLGNDVLTLQFCVNYGGRAEIADAAAAIAREVAAGRISPDKVNEKLFARYLDEPSIPDVDLFVRSSGEQRISNFLLWQSAYAELVFDDTLFPDFDRRNIWRACETYASRDRRYGGAIPNPVSIHDPVGQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ60</accession>
    <name>A0A010YZ60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">CryarDRAFT_1593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849439.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203263_0_0_11"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="55" mass="6326" checksum="C7EB895F998F82DF" modified="2014-06-11" version="1">MAVPKRKTSRSNTRSRRANWKAQPLQLVPITVDGRTGRVPRRLVRAYQLGILQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZD8</accession>
    <name>A0A010YZD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CryarDRAFT_1663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1633"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_11"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="422" mass="45024" checksum="703D7B17EB6ACD7A" modified="2014-06-11" version="1">MSLHSAVVDGYRPAGLDGLRSADPEVAEILTAEYDRVRHGVQLTASENFTSAAVRAVLGSTLGDKHAEGYPGRRYYGGCEFIDQAEELGRARACALFGAEHANLQPHSGTLANLAAFAALLVPGDTVLAMEPRYGGHFTSGSSRNFSGKWFHTVGYGVRRSDERLDYDEIRDLARQHLPKLIVCGPTAYTRLIDYAAFREIADEVGAYFLVDAAQISGLVAGRAVPSPVPYADVVTTTSHKSLRGPRGGIVLCTRALARRVDNAVFPFLQGAPQMNNVAAKTVALGEAGELAFVDYAQRVLANASALADGLESAGLRLVTGGTDNHMVLVDLGDAQVSGAEAEQRCRDVGILLTKHVLPFDHRLPEEASGLRLGTLASTTQGMTEADMEFAAELIVRAIRGEQGVGDDVADLAARYPCYSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZN3</accession>
    <name>A0A010YZN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-3' exonuclease (Including N-terminal domain of PolI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1717"/>
    <dbReference type="HOGENOM" id="CLU_004675_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="35834" checksum="937CA8C53A687F77" modified="2014-06-11" version="1">MSSPPLLLVLDGNSLLHRAYHAAATGKLLDSDDRPVWALKGLVGYVARASAKLRPDAVVVGFDCSERSTRQVDYPQYKAHRPEKAADLSEQITAAPDLLREAGFCTVVPSGFEADDVLASAAASARGGGWRSVLVTSDRDAFALIDEQTSVLRLRNGGLDEAVLMTPASLEELYGVTPALYGDLAALRGDPSDNLPGVRGFGTILAARLLGTFGSVEAAWAAGFDDVRAVVGEVAARSLATDEARERVAVNRRLMRMRADLELPPLDSARLPLSYGVMRQALAGRGIILGPSLWALTGRTPPPEPPEKGAQSEPPKYPRTVRARREPSPDQMALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0K6</accession>
    <name>A0A010Z0K6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2048"/>
    <dbReference type="HOGENOM" id="CLU_014793_8_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="31667" checksum="1C418B4337A0747F" modified="2014-06-11" version="1">MRLTADTVGTVSTGANANRHNEDLVREHLPLVGHLVREMLGRVPAHVNRDDLTSAGLAALAAAARSFDPTRGTPFGSFATVRIRGALLDELRGLDWASRSVRHRARKIETATAELTAQLGRTPTDTELAETLGVAVAELHSAADDVQRAVVLSLQGFAAGTAEDLVPDRTQGPEELLLHREKIGYLHQAISALPERLRTVVESYFLDERPMAVIATELGVTESRVSQLRAEALTLLRDGINSQLDPDQVAGADRPEGCVARRRAAYYADVAARGDLRTRLSHTTPLGTPTRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1X7</accession>
    <name>A0A010Z1X7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850760.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2507"/>
    <dbReference type="HOGENOM" id="CLU_022256_1_1_11"/>
    <dbReference type="OrthoDB" id="1653347at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="43948" checksum="298B885DFA914CFA" modified="2014-06-11" version="1">MVRNVSAPLHLAVAFDGAGWHPAAWREPEARPADLLSAGYWVDLAAEAEAGRLDFLTIEDAVGLQTSDFDRQDDRVDQVRGRLDAVLIASRVAPRTRHVGLVPTATVTHTEPFHLSKAIATLDYVSRGRAGLRVQVSARAHEADHFGRRQIPRLRVEDLRSDRLADLFDEAADYVEVLRRLWDSWEDDAEIRDAATGRFVDRDKLHYINFEGRFFDVKGPSITPRPPQGQPLVTALAHATIPYRLGARSSDVVYVTPHDVEEARTILAEVRAEQEAAGRSGETVHVFADLVVFLDGRDRKARLDEQAGEEYRSDALIFTGSPAELADLLLEWQAAGLSGFRLRPGVLPTDLEAITRGLVPELQQRGVFRRAYEADTLRGLLGLSRPANRYARAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z262</accession>
    <name>A0A010Z262_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2593"/>
    <dbReference type="HOGENOM" id="CLU_033975_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="357" mass="37903" checksum="401808F929DF4AD0" modified="2014-06-11" version="1">MGPLTGLKVIELAGIGPGPHAAMVLADLGADVVRVDRPPASGGEASDQTLRNRRSVALNLKDAEDKATLLRLIEQADVLLEGYRPGVTERLGIGPDDCAAVNPRLVYARMTGWGQDGPWAHTAGHDINYISVTGALHAIGRPGERPVPPLNYVGDFGGGSMLLLVGILSALFERQQSGRGQTVDAAMVDGATLLSQMFWSFRAVGVWSDERGVNLLDGGAPWYDTYECGDGRYVAVGALEPQFYAALLTGLAIDVPDRDDPANWPELRKRFTEAFATRTRDEWAAIFDGTDACVTPVLTFAEAPAHPHVAARGTVVEPNGVPQAAPAPRFSRTSPGAPTAPPGPGRDNADVLRDWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2G6</accession>
    <name>A0A010Z2G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="25981" checksum="994DAE1B1FB5140C" modified="2014-06-11" version="1">MSSVLTVKGLSKSFRGIAALSDVDIDVTEGTVLGIIGPNGAGKTTFFNVVAGAFKPDTGSVTLDGKDITGFPAHKVARAGMTRTFQLMRPFATLSVLENVAIAASVGGGSQRAARRRAEEVVASVGMDEWADTVAGTLHTAALKRLELARAIATRPRVLLLDEVLAGLVPTERQPVLDLLASLRDEQGLSLVFVEHIMAAVMRLSDSVVVFDRGRVIARGAPAEVVDDPAVVEAYLGTAPSTGETTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2J7</accession>
    <name>A0A010Z2J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flavoprotein involved in K+ transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851051.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2728"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_11"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="477" mass="53508" checksum="331C5E49CFA8E551" modified="2014-06-11" version="1">MRVAIIGAGLGGIAAAIKLRRRTSATVTIFEQSAGVGGTWFDNRYPGCEVDVHSHAYSFSFLRYDWPRTHATQAELLEYAEHVVDRFGLRPLLRLNTRVTDLVWEESTNTYVLSTEHGDTEEFDVVVSALGLLSVPRYPDWPGLDTFAGPCFHTSRWEEHDLTGKSVAIVGTGSTAVQIVPAIAPAAAKVHVFQRQPGWIEPKNEREFSPRERWVYRHVPLAQKLNRAWIFHKGNRRFKGYDTGSRRQRRMREVCRRFIAATIDAPETREAVTPDYPWGCKRPVLSSTFYSSLNRDDVALVPHAVSRVTPTGVVDATGVTHPADVLILSTGFQPTRFLASLDVKGRDGRSIHDVWRERAAAFLGITVPGFPNFFILYGPNTNGGVSVIAQLERQAEVVVRAVRRLERTRRASLDTSPEAARRFTAWIDRRMASTASAMDAGCHNYYHDAAGHNVTQWPGGHLAYALTTRFLDRWGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2S6</accession>
    <name>A0A010Z2S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051572049.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2804"/>
    <dbReference type="HOGENOM" id="CLU_069356_44_1_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="22853" checksum="8A4A64484B80541A" modified="2014-06-11" version="1">MEDAPAPGPIARRPRGSYSKGRAKRAEILSEAVRVFAESGYRGGSLKEIADRVGLSQAGLLHHFTSKEQLLAEVLAERDAEDGARMFPAGEPLTGREALERMAGQVRRNTTVPGLVRLYAALSGEAVADGHPAREPFVARYRDLRALMTRAVAEAQDAGELPSDRDPVMIATALIAVMDGLQTQWLLEPDAVDMPAVFDTLLSALGLHANTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4N5</accession>
    <name>A0A010Z4N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852008.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560399_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="171" mass="18579" checksum="06A011E532F8A9BD" modified="2014-06-11" version="1">MANIADSTVTFFALDPAVLVAVRDQVRPAVPWSPAHVLSLEAAVPTGLDLDDWDHERAFAAWGTSRPEVDSELLEEHADRLVYRVGTAWSGPETVWATLSAQHPGLVVHSVSSDGSEFSSCGWYVAGRAVRWEEGEPDVQDDGDEEVRHPAEWAFSESVAREVLADSGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z527</accession>
    <name>A0A010Z527_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Usp family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852253.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025706_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="28041" checksum="30F1B6C429BC80AC" modified="2014-06-11" version="1">MTSIEDRGVVTVGLDSPATTGPAVQWALEYARTRGAAVRLIAGRPYPGPAEQVRARVDDLVLLSRSTVPGLDVVGEVAAEPLGPALLAAAQSSELVVIGDRASRRHASDLRPTVDALVAWAECPVVVARSARWPNPEAPIAAALDGSDRDDAVLDTALELAARCVSPLVAIQLSPDGPDRATAARVATRLAHRERAYARVPVRFRAAVGPAAPVLLLAARWASLLVVGPPRADGVTRSVTHEAVCPVLVARRPSVAPGLAGLGGLIVSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6N5</accession>
    <name>A0A010Z6N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4154"/>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458967" evidence="1">
        <location>
            <begin position="30"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="47008" checksum="71D1274133EF30F1" modified="2014-06-11" version="1">MRRSFPRRAGRWRAPTLAAVLSLSVLATAACGGGGNAPSDKDTDVTITVALAADPPPKAALDEFKQETGITVNWVNIDWDSLQTKISAAATAKTYFADATNVDWSRVGELGKLGWYYPMDDYVDVNAMKADVPQLASFTYDGKVVGVPYDASFMVTTVNTELFKKAGADPAPKTMDEYTAALRKIKSSGTVKYPLNIPFAAAEGLSTYWYETTNAFGGTILDGKGKPQFSDPGSPGYKAAQWMVDALKSGLVPPGNINVTDSQGEQTLMARGSVASIFSDYSGLVGTLYNVPDSSSVVNKVAYLPTPGVTGPAANLSNPDGVGIMKTAKYPKAAAKFIDWFTQSDRQAEFAGLNGPEKAWASYALPSHLSAVEKLASDGKLIGGTELAALLKTSKPVFPEGAPAWYSKFSNAVYTHLHAAAAGSESVEQAVKAMSDTANDLSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKF1</accession>
    <name>A0A010ZKF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859899.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014270_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="221"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="449" mass="47046" checksum="D5F8A9890F809140" modified="2014-06-11" version="1">MFEQPVRYVAQTPLGPLDDSTLLATARERAAYLADASKQLAGSLNPDRTLRRALHVTVPAVADWAQILMPTRTGVRYTAVRADEPDRFVSEEGARPPLGELSGHGRILTTGRYELMHVLADGHVPDIVAATVPVGELRNGLLGLRPADLLVLPLTARGTTFGTLTLARRAGRGFENEDVAVAVEITGRIAIALDTARVYAEQAHVAEVLAASLRAPELPETPGLAIGARMRAAMHAAEIGGDFFDVFGDPGDWSVLLGDVAGKGAEAAILTGQARHTVRGAAFFDRRPAELLRVLNSALFAGADRAQPATRFLTALSARVTTRPDGSASVRIASAGHPRPLVVRTSGVVEEVPVKGLLCGALRTAEYTEVEQELAPGDMMLLFTDGVPDAVGSDGRFGLGRLSQLAAGYAGSGPHALAEAVDIAVAEYSGAGLAPTDDVAVLAFGGVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKS2</accession>
    <name>A0A010ZKS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">CryarDRAFT_0270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.257"/>
    <dbReference type="HOGENOM" id="CLU_106245_2_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="96" mass="10732" checksum="45AE3E9EC79C2C23" modified="2014-06-11" version="1">MTMIADWAGRAACRASDPDSLFVQGAAQNRAKTVCMGCPVRTECLADALDNRVEFGVWGGMTERERRALLRRRPDVTSWWKLLEAARKAHELQPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLE0</accession>
    <name>A0A010ZLE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848179.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.510"/>
    <dbReference type="HOGENOM" id="CLU_032482_1_2_11"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="52"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="38772" checksum="7412E8B10F5A9976" modified="2014-06-11" version="1">MTVLSDATLVLPVGVVQGGWVAVSAGEITAVGGPERSRPRDPDVVDLGGRWIVPGFVDLHVHGGGGLDYGAARPDTAGAITALHRSHGTTTSLASLTTAPLDDMVRSAAALADLVDAGTLTGIHAEGPFLSPAHAGEQDPAAMLGPDPDALDRLVRACRGHLRVLTLAPELPGALELVKRSVEQGIQVAIGHTGASYERTLAAIEAGASLATHLFHAQPGPTQREPGAVGALLEHPDVIVQLIADGVHLHDALLSMVFRLCGAERVALVTDAMAAAGAGDGRYRLGGREVDVRGGVALIEGNGAIAGSTLTQDAALRRTVDAGVPVTEVVTALTATPARALGLGHRIGALVPGFTADLLVLGPGLEIDGVMVAGTWDRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZML0</accession>
    <name>A0A010ZML0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">CryarDRAFT_0966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.950"/>
    <dbReference type="HOGENOM" id="CLU_041220_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="38"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="29502" checksum="955701DD294CFACD" modified="2014-06-11" version="1">MSSDDGLLGPAEIRTLAARLGVRPTKTLGQNFLHDPNTIRRIVRTAEVGPDDVVLEVGPGLGSLTLGLLGAAGSVVAVEIDPVLASALPSTVASRMPSLADRLSVVEADAMSVDLSGLRPTALVANLPYNVAVPVVLHLLETVPSLRSALVMVQAEVADRLAAPPGSRTYGVPSAKAAWYCAVSKAGSVPRAVFWPVPNVDSGLVRLVRRDPPDGSRKDTFAVIDAAFAQRRKTLRAALAGWAGGAPRAEEALRAAGVDPTARGETIDVGGFARIASARHVSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMU6</accession>
    <name>A0A010ZMU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848769.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1049"/>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_11"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="56"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="542" mass="58853" checksum="498F7AF5AD49D3C3" modified="2014-06-11" version="1">MDGVTRVPEPVNEPVRTYAPGSAERASLRSTVDRLDDQREDLTQTIGGVARWGGGDEVPVVQPHAHAHLLGTLRQATRSDVADAIGAASKAAPAWQRLSYADRAAIFLRAADLVAGPWRDVLNAATMLGQSKTVQQAEIDSACELIDFLRFNVHYGERILAEQPLSSAGTWNQFDHRPLEGFVLAITPFNFTAIAGNLPTAPALMGNTVLWKPSPTQQLSAHYFMRVLEEAGLPPGVVNLVTGDGAAVSEVALTHRDLAGIHFTGSTRTFRYLWETVGRNLDRYAAYPRLVGETGGKDFVVAHPSADPDALHTALVRGAFEYQGQKCSAASRAYVPRSLWEGGLRDRLAATVSELEYGDVRDFRFFGGAVIDRRAFDRLRDVLGKLAADPSCTVVTGGRTDDSTGFFVRPTLVEGTDPTHELFRTEYFGPVLGVHVYDDFDAVLDLAADTPYALTGSIFARDRDVLVSASERLRFAAGNFYLNDKPTGAVVGQQPFGGARASGTNDKAGSILNLLRWVSPRTIKETFAPATDHRYPHMLSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNE1</accession>
    <name>A0A010ZNE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="6">HIU hydrolase</shortName>
            <shortName evidence="6">HIUHase</shortName>
            <ecNumber evidence="6">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849003.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1246"/>
    <dbReference type="HOGENOM" id="CLU_115536_1_0_11"/>
    <dbReference type="OrthoDB" id="1955791at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="PTHR10395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="SSF49472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TR_THY" evidence="7">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="103" mass="11231" checksum="9E44B23E32E8D76D" modified="2014-06-11" version="1">MSLSTHVLDAVHGRPATGLRVTWHSGSAVVTRETDADGRVPSFGDTAPGVHRLVFATGPWFEARGQRTFYPEVSVVFEIVDADAHHHVPLLLSPFAYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNP8</accession>
    <name>A0A010ZNP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048544_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="27385" checksum="D6F79B4719B0EFC9" modified="2014-06-11" version="1">MGNSGAERPPGGWLVTTPATASTPAGPNVVGPAPAGPDVASPAPAGPDVAGPLTSPAKASVAEPSAIQVLTPAVVHAALVGGTVVAIRPARPRDAAAVADLHRRSAPASLRDRYPGTPPPALTDPEQCLAAVPGSCTLVAFNGFRLVGIAQITGHVPVADFGVLVREDHRRRGLGAILAKHALHVAYELGHREAVSFGGPENRALRAMLHRLGLEGRTRYTGDLLVTRIALPYEPEPADPEASDRTEPAVRMPYPVINRRPIATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPA7</accession>
    <name>A0A010ZPA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)H quinone oxidoreductase, PIG3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847480.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.75"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_11"/>
    <dbReference type="OrthoDB" id="1027479at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="33442" checksum="ABDF5D237B2E5623" modified="2014-06-11" version="1">MHAITITEPGGPEVLRWTEVPDLEPGDGEVLIDVVASAVNRADLIQRQGMYPPPKGASAYPGLECSGRIAAVGSGVQGWNVGDEVCALLAGGGYAEQVVVPAGQVLPVPEGVTLAEAASLPEVYCTVWSNVFAVGRLAPGDSFLVHGGAGGIGTAAIQLASAYGARVFTTASAAKHNVCLALGAERAIDYRSEDFVAVVKEATDGRGVDVILDNMGAKYLPRNIDALATGGRLVVIGMQGGAKGELNLGALLAKRASVTATSLRARPVSEKAEIVEDVKTHVWPLLGYGKIRPIVDRAIALPDAAEAHRALEEGSATGKVILVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPD1</accession>
    <name>A0A010ZPD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilase family protease/peptidase inhibitor I9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569537.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.100"/>
    <dbReference type="HOGENOM" id="CLU_000625_3_0_11"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PTHR10795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459144" evidence="5">
        <location>
            <begin position="25"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="172"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="7">
        <location>
            <begin position="413"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="fn3_6" evidence="9">
        <location>
            <begin position="636"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="940" mass="95892" checksum="C5B7408D1547A93C" modified="2014-06-11" version="1">MRRPVGFTSAGLALGLAIPSGALAAPSATPDEPAVMHLVQLVDAPIAAYPGGRSVPDGVLDGTRPRRGQRLGVDSVAVRRYRAYLDQQLRAVLKQLPGVRTAYAYRWTFNGFAAALTPDQVAAARRLPGVRSVTRDSVRTLDGLEPAGTTEFLGLPGPTGAWERLDGPARAGAGTVIGFVDSGIWSAHPSFTNPRPAAPRYRGTCDAGRVVKDFRCRGALVGARWYLNGLTPDAGEPRSPADHDGHGTHAAAVAAGAADVTAKFGPHELGAVSGVAPAARIAAYKACWQVDGEPTCAESDTVAAIDQAVADGVDVLNVAVDGASGGSPADDPLASSLYRAAQAGVFVAASAGNDGPSTRTAHGKPWLTSVAAGTHDRAPVAVVRLGDGTRLNGAGLGAGVPARPVVPGGQCREGSLDPGKIRGRIVVCLRGGNGRADKSAEVERAGGAGMVLANDDADELTADRHAVPTVNVDVRATAKLRDYLRDPRASAAFEPARMRPSGAPRPEVAEFSSRGPDGDALAPDLMAPGVDVVAAVSPARDGAMFGLRSGTSVATAQVSGAAALLRGAHPRWSPAAVKSALLTSATGGDNRISTSGGETAGPAEYGAGALAVDRALDPGLLFDSSAAATAPYSAQNTASVVLGSLAGVRTVRRTVTNVGSGTARYVARVDEPPGVDVAVSPAELTLEPGATASFTVTVHRVSAPYDQLAAGSITWSDGVHPVRVPVAVTPVVVAAPSSVELGNSLTVVPGFTGRLSARIAGPVPAVGHTTRLRVTGERARFSSAAPKASDRVARFTVTVPSDTALARFATDALDYPVGTDVDVFVYRDGKRVGRSGGPAADERIDLPAPEAGRYDVYVQLVDAPGTGALPVRLDSYVIDDGEPAAERSVNAGTPLRLSGVPAEGPGRWLGQIRWSDGGTGEATTLVSAVDRVFTDAPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ25</accession>
    <name>A0A010ZQ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.309"/>
    <dbReference type="HOGENOM" id="CLU_157938_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="6232" checksum="89A04768321C1BE1" modified="2014-06-11" version="1">MNSGLRGAMRRIRLAGEAGMSTAEYAVGTIAAVAFAGVLLKVVTSPTVQSALTAILAKALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ28</accession>
    <name>A0A010ZQ28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847860.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178652_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="25862" checksum="FACAD3B92F3D9DD0" modified="2014-06-11" version="1">MVLLGLLLAAVAIALGVGLALQPGDTANVHFFGLNIPNLNGRTLILVGIAIGILFMIGVSFIRWGFAIARRRRRERKAAKRASIGTPIEAPADAREPEPEPDHEAARREEVAAWERAEAARREEAARQEEAALRARSENHQPDPYPPGQPDPYPPASPDSYPGHRPPEPYRGDNSPTDAYPTMGEHKTEEYPTVDPYRDEPPRSTGTVYQSGGHSFPDNDPYGNGPQQPPQHRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ87</accession>
    <name>A0A010ZQ87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="7" type="ORF">CryarDRAFT_0397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569607.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.381"/>
    <dbReference type="HOGENOM" id="CLU_073198_1_1_11"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="20096" checksum="91D3163E9F9B97F9" modified="2014-06-11" version="1">MEFDVTIEIPKGQRNKYEVDHETGRIRLDRILFTATQYPADYGFIEETLGQDGDPLDALVLLQEPTFPGCLIRARAIGMFRMKDEKGPDDKVLCVHANDPRQEHLRDIHHLPEFDRLEIQHFFTVYKDLEPGKSVEGAQWVGRAEAEREIELSRKRAADAGHDAFTGTGDEHPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQF5</accession>
    <name>A0A010ZQF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850038.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1969"/>
    <dbReference type="HOGENOM" id="CLU_059021_1_3_11"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="162" mass="17045" checksum="4AAB72FD32EAC54B" modified="2014-06-11" version="1">MRAVAGAAPRELRDVYGAFPSGVVGLCALVDGVPVGMAASSFVAVSLEPPLVAVCVQKTSTTWPRLRDRPRVGVSVLGESHDLAAKRLAAKTGDRFEGLSIGTTDGGAVLIEGASAWLECTVDREVPAGDHDIVLLRIESFEYEPTVAPLVFHSSGFRRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQF9</accession>
    <name>A0A010ZQF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848101.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.467"/>
    <dbReference type="HOGENOM" id="CLU_017290_0_3_11"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="100"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="44705" checksum="89B2AEF3A3C08878" modified="2014-06-11" version="1">MTSLADAAEVVLALPDLYGRLQGTRLAGDFFRDQVLDGGYGACDYLLSADVEMRAAAGYRGDYGDFVLRPDPSTVRPLPWREDTVLVLADAVNVSGALVPVAPRQVLRTQLERLAERGLTAKVGTELEFLVFSESYREAFTTGYRDLRTASRYNSDYALTGLGELDDLVGALLRGMAGAGLRIESARGEVHPGQYEIVFRYGEAMAACDGHVFYKSGAKQIAERAGRSITFMPKFDSGEGNSCHVHFSLWSGDRPVFDEHFLAGVLACAPAFTVLGAPTINAFKRLSPDAFAPTAAAWGTDDRTRAVRVIGAGPSRRFEHRIAGGDANPYLVVAGIVAAGLYGLERELPLPPPGGDGEPLPRTLEAAAAAWRGSAVAREAFGDEVVEHLASAADAELTAFAAVTTDWERQRGFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRC2</accession>
    <name>A0A010ZRC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2272"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="418"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="504" mass="54448" checksum="AC2FEC926AD44100" modified="2014-06-11" version="1">MTVRLVDYLDKGASLGPDAPCLTTDGRSSTYAQVRELSFRIAAALARQNVAPGDKVAILSANDPIAFTCVFGISRAGAVWCPINPRNEAAETRELLELFECGVLIFQASFAPLVTRLELPLTLVCLDGDVEGALTWDEFLVAGGEPDRPAVDDLAMLVGTGGTTGRPKGVMLTGANLEAMTALTLMSYPFEGRPTYLALAPLTHAAGVLCFPVLALGGEIVVMRAPDVGAFLALVERHRVTHTFLPPTLIYLVLDHADLDRADLSSLQCFWYGAAPMSTARLAEALRRIGPVMGQLFGQTEAPMMISTLAPRDHFRADGSVATDKLSSAGRPTPLVTVGIMAEDGALLRRGERGEIVVRGSLVMRGYYRDPAASERASTHGWHHTGDIGYLDEDNFLFIVDRAKDMVITGGFNVYSTEVEQAVMAHPAVQDCAVIGLPDEKWGERVTAVVQPRRGQEIDPVELAAFVKRRIGSVKAPKQIEVWPDLPRSKVGKILKNEIKQTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRG3</accession>
    <name>A0A010ZRG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin isomerase</fullName>
            <ecNumber evidence="6">5.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.1.2" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848541.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.805"/>
    <dbReference type="HOGENOM" id="CLU_084703_0_0_11"/>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="11"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="21577" checksum="CF3DD2AC9539513D" modified="2014-06-11" version="1">MSGQYIRDGAEIYRHSFAIIRSEADLSGLPEDVARVAVRMIHSCGMVDLVDDLAFSPGAVSGAIGALRSGAPILCDAQMVASGVTRRRLPASNEVICTLNDARVPSLASSLGTTRSAAALELWREHLEGSVVAIGNAPTALFHLLEMIAAGAPRPAAVLGIPVGFVGAAESKEALAANDLGLEYLIVRGRRGGSAMTAGALNALASEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRI6</accession>
    <name>A0A010ZRI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.842"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="23536" checksum="CCFC7615901FC203" modified="2014-06-11" version="1">MTPPVRVLIVDDDAMVRAGLTMMLDGAGREPTIAVVGAVADGVDVPQAVSAHAPDVVLMDIRMPKLDGVTATRRLRRRPEPPEVIVLTTFDTDEHVLQALRAGASGFLLKDTPPDQLVDAVLRVASGDPILSPQVTRRLIDRVAVEAGAFERARAALDALSPRERDIVQAVASGRTNAQIAAELFVSVATVKSHLTRVLVKLELDNRTQVALLAHDAGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRY4</accession>
    <name>A0A010ZRY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850718.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_14_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="35931" checksum="16216377924533B3" modified="2014-06-11" version="1">MSGAAGQRIGFRAVPGGRVAYAEVGDGPPLVLPTPWVSHLERDWEVPEYRAFVAALAGTHRVVRYDRLGCGLSDRPARPGTGVQHDTAVLGALVDALELASFALFGFSIGACAALGYASARPERVSRLAIFGGYAEGARTAPEALRTAILATVRAHWGAGSRLLADVWMPGVDARVRDAFARLQREATDARTAAAVLASVYDADLRGALAGVRAPTLVLHRREDRAIPFALGREVAAGIPGARFVPLEGDVHPPWLGDSGPVLDALLPFLAADTAPGRVLTEREREVLRLVAAGRSDSEIAAELFLSGHTVHRHVANIRRKLDQPSRAAAAAAAVRLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS35</accession>
    <name>A0A010ZS35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167388_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="84" mass="9355" checksum="7097F830C7D521C8" modified="2014-06-11" version="1">MEYRDAAHLRGTQAWKRARAYVLKHSRTCWICGHGGADSVDHIVPMALGGAPLDFANLAPAHMRCNSRKGKKPIVTKLKTSQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSI7</accession>
    <name>A0A010ZSI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569818.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1234"/>
    <dbReference type="HOGENOM" id="CLU_069356_1_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="22086" checksum="869859FA2E4C6F19" modified="2014-06-11" version="1">MADSREALLAAAAEEFAQFGLHGARIRAIVAKAGVNERMIYHHFGSKEGLYGAVMDDQRRAVAQAWWPALEKARTMEPVEGMRFALRASLDLAMNHPHRSALFLQEQLAGHFGTLHPTSAAQLPAPLRELYERGQQDGAFRADLPFELAYSTAIGSIFAMGATSARSFERLVPMIHLDEERAKELVIDQFVQGMTQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSN6</accession>
    <name>A0A010ZSN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="362"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="556" mass="58845" checksum="5860BFB2B6DA38B6" modified="2014-06-11" version="1">MERRRRLAVTAVAFATAYYAIALFFVSDSDAFTAVAAVGGAVACFAAAGGATWAARHTRRTSRRGWTAVAAGLALWAAGNTSSFLWYLSGIDQYSRTTDAIYLTAIPILLFGLTSLLAAQLPAVSLRLVLDGVIIAGSLFLVSWGMVLGPIAAEQQSPINWAISIAYPVTDVMMATVVLLVLSAGAPGTRTPLSLLSAGFLLTAVGDVAYALFDHLGNYSSNGAVNLVWFFSYMLMLLGGVWVATDPRTEPQQVTVPPYTLLPYIPFSLSIFTAQAVYFATGGIGPVLVVGCSALVMLVLGRQLTMVRENVTLNARLATTVAKLRRREEELRHRAFHDGLTELPNRVLFHQRVEEAIAAHDDEVTVLYVDLDGFKAVNDQHGHDVGDTLLTKVADRLRECLDDHLVARLGGDEFGVLLPGTTSPSVSTELAERIVSTIAGITTVDGHRVRVGASVGIAVNQTDGGVGELLRAADLAMYAAKVEGKGRYALVGSAITAAAATSPPAARDDHARPEPSEDGSPDQAAASSAAPNETWKRAHQIETLVSVSKSASAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT91</accession>
    <name>A0A010ZT91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849307.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1479"/>
    <dbReference type="HOGENOM" id="CLU_083287_2_2_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="17474" checksum="6A8D283AF5674903" modified="2014-06-11" version="1">MEETRWLSPDEQRTWRSYIEANRLLNEALDRQLQRDAGMPHTYYEILVRLADVPGHSLRMSELAHSSLSSRSRLSHAVSRLEERGWVRRESCPTDGRGALAVLTDEGFAVLEAAAPAHVAEVRKRLIDLLTPEQVDQLGEIARAICAGMNETVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTD5</accession>
    <name>A0A010ZTD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
            <shortName evidence="7">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">valS</name>
        <name evidence="11" type="ORF">CryarDRAFT_3094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851486.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3054"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_11"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="649"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="574"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="826" mass="91393" checksum="B9D8AD77A25112E5" modified="2014-06-11" version="1">MTDTAAPPERPSLEGLEEKWSDAWEASGLYRFERAVSRSDVFSIDTPPPTVSGSLHVGHVFSYTHTDIVARYQRMRGKSVFYPMGWDDNGLPTERRVQNHYGVRCDPSLPYDPDFEPPAKAPKRQLSISRRNFIELCERLTGDDEKQFEHMWRRLGLSVDWSMTYTTIGARAQKASQTAFLRLVRRGEAYQSEAPTMWDVTFGTAVANAEVVDKEVSGNYYTLAFGDVLIETTRPELLPACVALVAHPDDERYRHLIGTEVETPLFAVRVPVIAHPAAAPDKGTGIAMVCTFGDSTDVQWWRDASLPTRTIVGRDGRVLPLDFGALPTSDAAAAQKLMDELAGKTMFSARELLLERLRDAGALRDDPRPTTRPVKFYEKGDRPLEIVSSRQWFIRTLGHRAELLARGEELRWTPPYMKARYDDWVRGLNADWLISRQRFFGVPFPVWYPVSADGEPDYGHPIFAAEQMLPVDPSDACPPGYTAEQRGKPGGFVGDQDVMDTWATSSLTPQLVTGWLTDPELSALTFPMDLRPQAHDIIRTWLFATVVRSHLEHGVLPWRNTALSGWILDPDRKKMSKSVGNVVTPTHLLDDFGADAVRYWAANGRPGTDTAFDTKQMKIGRRLATKLLNATRFVLAVGDAGGEVTEPLDRALLASLDVVVAECTAALDAFDYTTALVKAERFFWLFCDDYLELVKARAYEGGASAAATLRQALDVLVRLLAPFLPFVTEEVWSWAHEGSVHRAPWPSASGTDGDPVLLATASATIAAVRKAKSAARLSPRAEVARITVTGPSEAAFRAVADDVRAAAHAAELSFTGSDEIVATVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTG1</accession>
    <name>A0A010ZTG1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="6" type="ORF">CryarDRAFT_1592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849436.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1564"/>
    <dbReference type="HOGENOM" id="CLU_139869_0_1_11"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="11532" checksum="C9DD341A0F937652" modified="2014-06-11" version="1">MAKKSKIARDARRRVIVARYAERRAELKRTIADPRATDDDRAAAVAELARQPRDASRTRVRNRDAVDGRPRGHLRKFGLSRVRFRQMAHAGELPGISKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUG0</accession>
    <name>A0A010ZUG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849929.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1890"/>
    <dbReference type="HOGENOM" id="CLU_089257_0_0_11"/>
    <dbReference type="OrthoDB" id="1522794at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="26156" checksum="BBE407565D4434CA" modified="2014-06-11" version="1">MTSATPEKVGFRQRVRQIFQVFKFVRGHDRLIVPLMLAAFLVPLLVGIGVAWLTGLWVIVPLAVLIAVLATLIVFSRRVQKATYAQVEGQPGAALAVLESMPGNRNQRNWKFTPAVQVSQQQDVVHRVVGRPGVILLGEGASHRVKQLVSTERKRVSRVLTDVPIHDVLVGEDEGKVSIRKLQSHLQKMPKSLTPGQVGQIAQRLQGLGGARPPIPKGPMPKSARAMKGAKQQMYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUP8</accession>
    <name>A0A010ZUP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2069173_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458088" evidence="1">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="118" mass="11665" checksum="563DB7F67A619CA9" modified="2014-06-11" version="1">MQPPRRRSGLTVAAGVGAAAAVFAVKMLAGALQPNTAPDGVDLAQATAAPAGPDVPANLKAPPVEQRYHVRTGASADDVNRCRQAAAPTTVGTPLFTAAARGATMVVFGAGTCLGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW01</accession>
    <name>A0A010ZW01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570075.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2472"/>
    <dbReference type="HOGENOM" id="CLU_013382_0_0_11"/>
    <dbReference type="OrthoDB" id="1643926at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="855" mass="85988" checksum="E602E63F70225FFD" modified="2014-06-11" version="1">MTGERTITLLLRVAVVCAVVVIAAITGMTAVPGLPVAAPAPVTPATAHVVVVGVPGLRWDDVDAQRTPALWRLLRAGSAGALSVRAAGPLTCPADGWVTLGAGNRGRGPRHGTTCPDQFPLAAPDLAADGGAPRETGARLPQQADIIARNSALTQGTRPGALADGVRCVTAVGRGAAVAAAHPSGRIDRYAAILPGDPSELLTRCPVTIVEGPSISDRSGEPTRHRVAAAADAIVARVDDARPTGSVLLVVGISDTGDVPRLHVAVAVGPGFTPGAELTSPTTGKAPFVQLMDLAPTAISALGLDPVASMNGVAIVSAGAQAATPAGQVARLTDHDRAAGAQRPLVQPFFTIMVVAVLALMLVSWWLVFRRWHTVVAESGPPATLRPSALRGGASGAGLRVVPGADGATGAAPAKAGRVRWPRAIEVVEVLAVTLATVPVAAFAANVVPWWRSDHPLFVLVALILAGVAALTGVAYGGPWRGRPTGPIGCVAIGTTLVLAADVLTGSNLQLNAVPGYSPLVAGRFTGFGNLAFGVYAAGVLIGVGCLAQATPGWRRPTLFTVAGAAAVLVVGAPGWGADIGGILALTPAVLLAAVRLSGRRVSSGVVAGAAVAALGAVSAFAAADYARPEADRSHLGRFVAQLLDGEAGTVIQRKAEANVTLLLTSQLTILVVAVAIFVTFVLLVPTARLRRVLGLYPAVRAGLTGLAVAAVLGFALNDSGVAVPAFAAMVAVPLAIALTIRVALAGRRPARRDLPVWNSSAPSAPPPPSPGPGSGGAPDDPSDPSDPEPPSGSSPGEPPSTGGDPVVPAPITVSEAPRPDPETPPDADGSPRVPRARTEAGEDETVATQGRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW20</accession>
    <name>A0A010ZW20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570692.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4040"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_11"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="28606" checksum="0730AFE996DE8497" modified="2014-06-11" version="1">MADQRGMAVGTHLKLAAPPTFDSVDDERAHRKAVLAAAFRMFSRAGLDEGVAGHITVRDPGEPDTFWVNPFGMHFSLIKSSDLVRVGHDAQVVEGDRAVNGAAVAIHTAVHAARPDVLAAAHAHGPAGKTLSALDMTIEPLTQDACAFYQDIGVFDDYTGVVLDPAEGKRIGEALGPHKAVILRNHGMLTVGASVESAAWWFLTLERTAQCQLQAYAAAAGHGSKPRLIRPEEAEATRGQVGGEFAGWFQFQPIWERISADHPDVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW75</accession>
    <name>A0A010ZW75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570089.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2545"/>
    <dbReference type="HOGENOM" id="CLU_350184_0_0_11"/>
    <dbReference type="OrthoDB" id="1790198at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="768" mass="81781" checksum="14C015FB806E986B" modified="2014-06-11" version="1">MPKVVELLVHGVGGATPIEQLDDPSPARVSGDQTVGFYRHKSPPPGLIPPDVLPGTGADAPGERSAAVRSELVQEAYCWSGLTSASASRAAWLILLPFTLVNAAAWMRPTGPPGRAGRIGRATNDAVARLLALSLTGTFLLAAGGVGIDLIGWQCAARPQCGSHWSVLAFLAAPDSWAHPAGRRLALTALVPLVLLGLLWFLARRSWVAYESVRFRVDVAEGDGGLSEPGFWEGEFQVGRLRTLHVSLGVVTVALMLTVPALTVDGDSTWGRVLLGVVLAVLLWVVAATAAQSGTRAVPGLALLRLAAFAVLVAAVVYVLAPHDWPGPGHRLPGYGSLLMLWVAGQIVLLLASVVAVALIGRGSSGQMLRGFITPVFAALALFLGIAYSAAVLTRVSDWLGHVEGTAVLLARPPAVVSWAAVAFGLEIVLVVLLVLYLVVRVSWRVRRGWRAVLTEYDAVPTAPHTPGSGPVPEVSSRARGQAKKIVRMRAIATLTESAGRYLAVLVSPLVLLASYGVVTTLTDWVTPPTPRTYATQYVNPVPGIVTLLYNAGSWVVGLTAVGLVTLVWQAYRNEALRKVVGVLWDLGTFWPRAAHPLAPPCYGERCVPELVARITQLTEQGHGVVVSGHSQGSVLAAATLLKLPAERASRVALLTHGSPLQRLYGRFFPAYFDAGQLGVLAARLPRWRNLWRLTDPIGGPIDPVERHEPLRDPVRFFPTVHEVAYPPVRWHLDYPLDSAYGDELAAAADAVGSGEPLRRTSPGPNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWA4</accession>
    <name>A0A010ZWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570708.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4128"/>
    <dbReference type="HOGENOM" id="CLU_041141_1_1_11"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="35831" checksum="848E24E8C4FBBFB0" modified="2014-06-11" version="1">MARPTARVLSLLELLQSGGVRTVGELAGRLGVDERTVRRYVQHLVDLDVPVESVRGRYGGYRLARGHRLPPLMFSEDEALAVLLSLATARTGDTAQETARAKLRRVLPAPLARRLAAVLDSVSWTAPVAAPTPDSEILLPLAAAVRDHLPVRLAYTTADGRRSERTLHPHALVVHNDHWYVTGAADGEDRVLRLDRIASVRTGPGTFTPPEHRDPAEHLLHRLATVPYRHHVRLRVHATPAQVRRRLPPGLALVHDRGDHLDVELRVESLDWLPAVLASLDAPFTVERPAELRDLVAAFADRLRAYATGDTPAAPPGDAESHRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWF4</accession>
    <name>A0A010ZWF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853166.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4180"/>
    <dbReference type="HOGENOM" id="CLU_001681_5_0_11"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="35420" checksum="F04FFD694A9E5B35" modified="2014-06-11" version="1">MALRRGRGYASVNYPTGMNLGGDPSQALVHATTMGGFVVTLSSVDLGQGITTVARQCAAETLGVPVESVLVDTADTDTGPHCMGTFASRGTHRVGNAVIMAAQEAREVMLRVAADELETDAEDLETDGTGYIVVKGATQRRIHVSDVALAAHFAQGRTISGRGIYLKERNYPDPETGQMDPDSCQAHACTVADVVVDDETGVVEVVSLHNTYEVGRTINPGLATQQVEGGAWMGVSHALFESCEPGYPASREHGPISFSDYLMPGPADCPEQVSVLLERPAENGPFGAKGIGEMTANAPIPAIANAIFDAVGVRLTVMPFTPESVLRGLDALREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX60</accession>
    <name>A0A010ZX60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="19490" checksum="6BB3FB633CFFBDE2" modified="2014-06-11" version="1">MTDQPDQAYREYVTDRQHMFRRLAYLLCQDWHSADDLVQNTMVKLYLRWERVAAATDRDAYARTVLVRVFLSERRTSWARRVVLVDAGQDTTAVSDPDPAAAVAVRAALAALPPRQRAVIVLRFYSDLSVDQTADALNCSAGTVKSQTSRALAALRRALPDEEPAQHHRGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXF5</accession>
    <name>A0A010ZXF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyanate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570230.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_0_0_11"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="5"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="39769" checksum="AF902EB838B30CE1" modified="2014-06-11" version="1">MTAASLRSSTVAVYLAFSGSGFLFATWAARIPSVRSQLGLDARELGLLLLALPAGSIASLLVAGAFVARSGPRRAVAAAGLAGATGLGLAGLGAPGSVVVTAVGLALLGLATGVWDVAMNVEAAAVEQARGVAIMSRFHASLSAGTVVGAAVAAACAAVGVPVTAHLVAVGLLIGVAVPLSTRWYLRAETPEDRPAGSALRAWTEPRTLVLGLFVLTMGFSEGTGNDWLASAMIEGHRTSVAGGSLTFALFVAAMTVGRWFGPPLVDRFGPRPVIRVGAVVALAGLMATVFGPNPLTAVIGVVGWGLGTAMGFPLGISAAAEDPRRAAARVGVVSTIGYTAFLAGPPLLGFAADHVGILRSLSITAGLVAVGLLLATGLPERGVRGGSPPRRTAVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXM8</accession>
    <name>A0A010ZXM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570251.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713132_0_0_11"/>
    <dbReference type="OrthoDB" id="2063529at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="41545" checksum="313D34A8798C7113" modified="2014-06-11" version="1">MPPTASLTADTDPGKINETTSHSDLTTTPLAADPPAAPPDGAAVQTAAWIFYCIAALGSAIGQIWVGIDAPPWPPEIDWWWRALIVTPFAIVIDLGGVVASAFADFRRRLGETAYGWRVLSAGAVSVAVSINLVGHYHVPYLSVVFGGMGIFAYAVWLLHAAARRRDALRAAEKLAETAPVYGLRQELREPAVTGRARQLAVDFGYSRQESLTVARQQLRGEQRHAALSMHINKLIRARHQDPILAEIAVTTLDIDAISAALTAQSDSAAWARIIGAQLTPPGTDRNAPPPRGATPPADVLRRVPRDPASYERWRQLWAELRAGPDISSSEFAARHGISTRQVQWIRSVGQSGLLDSPVPLLNRVADLAVSGRSPAGDPTNGAVPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXS9</accession>
    <name>A0A010ZXS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851548.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3117"/>
    <dbReference type="HOGENOM" id="CLU_021082_0_0_11"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="613" mass="68815" checksum="F151238970B1601F" modified="2014-06-11" version="1">MGFLTPMYELGEYLAWTRSGEIQLPDFQRGYKWEDERIRQLLITVLRGHPLGAVMLLKTGNSQVRFKPRRLEGVELPAGTEAKFLLLDGQQRLTSLTQALSGDGLVATKDSRGKLFNRRYLVHMPTALADPNRVDEAVISVPADGVVRTNFGKDVVLDLGDHDKQRAQGYFPLHLLYGDYMSWILELDDRALGKTFHEQFIKPAATYDIPAIVLDEKTDKAAVATVFEKVNIGGLPLNVFELLTAVFAGDADHYARTKEDFRLNDDWRDTQLKWSSSPVLGVVENTDFLQAVTMLTTRKRNLADASDRPPAISAKREDVLKLTLADYLEWRDPLREAFVWAATFLADRHIFVPRDVPYAKQLVPLAAIKVVLGKDADLIGVSERLTRWYWCGVMGELYGSAIETRFARDIEMVPAWALDGSAVLPRTVADASFTESRLHSLRTRNAAAYKGIAAMILAVGARDWMEDKALDKMQYVDLAVDIHHVFPQKWCYDHGVDDEHRESIVNKTTISARTNRAIGGTAPSIYLQTIQTRAQIDRAKLDELLRTHLVPADLLGADDFDGYFAARRESLCRLVEAAIGKTVQRDVGEGEAGEDSAHFEPEELRSELIDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXY8</accession>
    <name>A0A010ZXY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851644.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_1_1_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="32173" checksum="2FABEABB5D4F3E24" modified="2014-06-11" version="1">MTPELLEVAPGVHAYVQPDGTWMINNTGVIVGPAGRALLIDTTSTEVRNRALLASAASVAPGGTWAAVNTHHHGDHTYGNWLLPSSTPIVGHALCREDVVAAGLVAAAVLTDPDYGHLEVRAPDVTFTGSMTLHLGSQVVELHEVGPAHTRGDLIVWLPETRVLFAGDIAFAGGQPFLAEGSLAGYPKALAAIRALDPEVLVPGHGPVCRGSDIPRLLDALGSYAAFVDEIARTGHTAGWTPLETALRHTDNPFAGWKDAERMVGNLHRAYSELDGQPLGTRLDLTTIWPDMTAFHGGPIRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY63</accession>
    <name>A0A010ZY63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851750.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182306_1_0_11"/>
    <dbReference type="OrthoDB" id="2013794at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046030">
        <property type="entry name" value="DUF5988"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19450">
        <property type="entry name" value="DUF5988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="68" mass="7653" checksum="AF955852F50193CD" modified="2014-06-11" version="1">MTTFVLLDGGPHEFLGTSYRVDAGGLESRIKIAHGNGYEHYTHNGTFRVLDGEQLPVFVWCDRTRIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAM8</accession>
    <name>A0A011AAM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568122_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045629">
        <property type="entry name" value="DUF6232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19744">
        <property type="entry name" value="DUF6232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="18042" checksum="9ACDCCE5CDFEA9CB" modified="2014-06-11" version="1">MTPPLGTVQVILNKRTLRIGHQTYQLQNLARVQTVRLPKPLDAEKGNSALAVLTAVGVLVVAGIISGAAQTEAICGLGVPLAIGLAIFVYLRTKKTWVPLYALVLETTGNPVTALVSPDSNEMEHLSGEIVEAIENPPEVERILQVNNVTLGDQYNQSGTQNIGRIGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABC9</accession>
    <name>A0A011ABC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3182683_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="46" mass="4983" checksum="C979CB96FBD2DB36" modified="2014-06-11" version="1">MLTLRGRICANRIDSDASTFRTLMPVTVDVTHLAPQVAMPAVVNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC60</accession>
    <name>A0A011AC60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848384.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208380_0_0_11"/>
    <dbReference type="OrthoDB" id="2028106at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="7438" checksum="583DB7DC39739C27" modified="2014-06-11" version="1">MPVQYRKQHSFGPFKINMTQNGMSSWSFKLGRWSWNSRTKEQRYDLPGPFTWRSGGRKRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACC1</accession>
    <name>A0A011ACC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.716"/>
    <dbReference type="HOGENOM" id="CLU_670338_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="43583" checksum="67235ED909F05403" modified="2014-06-11" version="1">MTSRPIAPRGGPVSPAATPEEFERELNQLTLGGEGWSAILRRLAAHTGHAAWLFDVHGALLATSVPPGTEAPNVRASDVAQVFGAERPVPLTMSDGRPVRAAAVRADRRRFGIVLLAEPVSPPVVPYLLAATTALAIEAVRRDAAAEAGSAAGADLVDELRCGTLRAPDDLTRAAARFGMRLDAPHAGAVFDYDGPHVRAWATALPRAGVTALHQGRRAWTVLPGGEDGELERLRERAQAVVGDGVVRAASGPVVNGADRTANSFREAEVLLALLLRRSSTRGDALVLPYGSLGLAQLLVTVPPERLREFVERHLGPLLPREDLIRTLRAWLASSGSRTAVADALHLHRNSVGYRVGQIKTLLGVDPLDPEAIVLLQAALTAQELLLALDEHDPVVGGWFSDRPGVTKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACP9</accession>
    <name>A0A011ACP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848596.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="23790" checksum="509242EA9DCB0DBA" modified="2014-06-11" version="1">MDIAGKVVLVTGASAGIGAATARLAAKLDARLVLAARRGDRIDALADELPDAIAIPTDLTDSGQIPTAVQVALDAYGRVDVLVNNAGQGLHVPLEQVDADDFRAVLELNVVAPLIAMQAVIPTMRRQGGGAIVNVSSGTSRLVLPGLGAYAATKSALNMLSAVARKELAADGIVVSTVYPLITATEFHDVLRAGSLSDRPGMPPPQSPERVADAILDLIRTGDEEVVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD97</accession>
    <name>A0A011AD97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848792.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2492616_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="86" mass="9637" checksum="1C7EC70B15938AAD" modified="2014-06-11" version="1">MKYIDEAGREFFVNILGQLVPANRPLDPPDHWPEARKAGWRVGAAAAHEANLAGRRMSSAQVRRLRLLLGLVDDHRSEGKPVRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADG6</accession>
    <name>A0A011ADG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAS/PAC sensor hybrid histidine kinase</fullName>
            <ecNumber evidence="9">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1137"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="232"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="374"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="629"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="748" mass="80284" checksum="B946E27E53CCD7F0" modified="2014-06-11" version="1">MRQGTGVTEHGVQEMPSAIVAIDPDGRITQANSCAEDLFGYSWDELSRRPLDDLFREPTELPDVTGDIELACRRKDGSLFDAELSLTPMDTPEGQLVSIEIRDLGQRNRAVERMRWLSAIVEHAHSPIVSADVDGIITSWNTAAERVYGWTAEAMIGRPISTFTEPVHAEVVSETLAKVREGETVHIPDGQIVRADGRRVAVSVSASPIVGPNGSIAGIAYAARDLSESERAEAKFRWLLNATPLPIVGVEVSGRIRMANTEAARTFGYLVDELIGEHLDTLLPDAQKAVTAESRHDPRDPVSEPTRLAGHRKDGSLFPAEILLSSLLTEDGLLIAVTVHDITARLESEAERVRLENQLQRSQRLDSLGQLAGGVAHDFNNVLAIILGHASIAEEDLAGITHLDDHGRLAGALRAVEQMHQAAERGSRLTKQLLAFGRREIVRPQVFLLSEVTADVVRLLAGTLGADVRVSTSSDADLWPVTADPGRIEQVLVNLAVNARDAMPQGGTLQIDAVNVALDSAQAARYGLTDGRYVQLRVTDTGTGMPPEVVERAFEPFYTTKPDGQGTGLGLASVYGIVSQAAGHVYLRSRPGWGTSVTVLLPASSGEPSVRPGAQHPAAPAESTEPERTVLVVDDEPDLRKSIEIILGRGGYAVLTAGSGDEAAQLASAYPGSIDLLLTDVTMPGLSGQEVARRLRADRPSMRVLFMSGFAQPLLTSKGTIGPDVTLVEKPFTRRSLLAKVAEVLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE14</accession>
    <name>A0A011AE14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849071.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1302"/>
    <dbReference type="HOGENOM" id="CLU_020336_12_3_11"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="29929" checksum="DC9DAAABB84255FD" modified="2014-06-11" version="1">MADITAHHGIFRDTKLHVDDTGGAGRPVVLVHGWPLSGESFKYNVPALEAAGYRVITYDRRGFGRSDKPLTGYSYDSLTQDLHTLLTELELTDVTVVGFSMGGGEVARYFTRYGAERLRSVVFASAVPPYLAKTPDNPEGPLEKSAMAKMTAGLTANQHKFYDQFITEFFSVNGVPAVTEAQRHEALELAGQSSKAAALEAMTAFGTTDFRDDLPRVSVPALVLHGDSDATVPFEGSGARTVKAVPHGELYLVAGGPHGCNVSHADEWNEALIAFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF85</accession>
    <name>A0A011AF85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849713.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_2_0_11"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="229" mass="24400" checksum="7C54F2BD383FD680" modified="2014-06-11" version="1">MTAHDLDLEAVDFLLNQHAQIRAGLREVAGAHGPAKAAAFADLRRLITVHETAEQEVLHPRMRELVPGPPDAGARPARERESSAAESSAPGSFGSGSFGSGSFGSGSSAPAGAASAAARLDVNSLLGQERHGTELLAELDRLDPASPEFDKRFTRLAVEIIAHADHEELEEFPVVRERLDLDERLRMGHALRVAEAAAPRHPQPAATPASVGAIVDRVRTALRDVFTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFX9</accession>
    <name>A0A011AFX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850060.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1991"/>
    <dbReference type="HOGENOM" id="CLU_076582_1_0_11"/>
    <dbReference type="OrthoDB" id="1616312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="27173" checksum="2BBDF187DC642A80" modified="2014-06-11" version="1">MAEGNNSNAQRIRELNDSIRYTMWSVFRASDRLPADRTALTTEVEELIEQLGQKDVVVRGIYDVSGLRADADVMVWWHASTSDELQEAYARLRRTELGAHLQPVWSQLALHRPAEFNRSHIPAFLADEQARDYVCVYPFVRSYEWYLLPDEERRAMLAEHGKMARGYADVRANTVASFALGDYEWMLAFEADELHRMVDLMRDLRASTARRHVREEVPFYTGRRKPVAEIVAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGU2</accession>
    <name>A0A011AGU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725893.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134465_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="14175" checksum="A2AE211C4A4D75BA" modified="2014-06-11" version="1">MTNPLDQTVAFGFTVRVETDIRGALASALKSALKQRDREALSVYRTALAAIANAEAVSAGEEHRAGAIEASVTGVGGAEVARRELTEDDVVTIVRNEIAERRSAASAVRSANPVAAERLERDASLLEAVAGSGADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGW6</accession>
    <name>A0A011AGW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2304"/>
    <dbReference type="HOGENOM" id="CLU_084417_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="23948" checksum="0E56CDA89E1783D2" modified="2014-06-11" version="1">MEHLVRGVDHAAFPTFDPAGTVKFYRDTLGFPVVHSICAAGWGPEAHPDFIHFFFDIGGGDRLAFFYYFGLPAPDTSGGQGDVYARFGDDTPLFFVRSRHLALHVDSEKHLLEYRRRLDASEWPVEMQIQHETIESIYTHDPNGYMVEITRAMRPVTPQEDLDANLTIDALVDVVARPGAGMDDLLVRKAELIVERAAQWQEQHAAPEGPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHD5</accession>
    <name>A0A011AHD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085660_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="25172" checksum="C10CE3ED5B516AD7" modified="2014-06-11" version="1">MSIVQNPPGTTVEPHPLDHAAWASLTGAHRHLAQIHGQAARYLPDVSPLGVLAPGADARVWDDVIALLGPDAVLSLTALDVTPPESFGIEFSAPGVQLIDATVDARTDPEAIRLTTADVPEMLELVERTRPGPFARRTIELGTYLGIRREGALIAMAGERMRPPGHTEISAVCTDPAHRGQGLGSRLVLAVAAGIRARGEVPFLHAAATNTGAIALYEKLGFVLRRNTTFSAIRTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHL9</accession>
    <name>A0A011AHL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850864.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2596"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="26942" checksum="BE918E0FD75F4FFE" modified="2014-06-11" version="1">METSGSPSPLAGRRALITGGSRGIGRTIALALADAGADVAITFNRDTAAAATTVDEITARGRVGRSYQGSVVIPADVAWQMEAAARDLGGLDLVVSNAGTAGTGDPVVETDPAELERMLRVHAFGPHHVAHAALPHLRRNKRSDLVFISSVATDTHPANRAPHSMGKAATEALAHTVAKEERSRGVHVNVVAPGLVATDMGLNFARLSDMDLREREERSPFRHMCQPEEVAEAVLFLVTASYVNDVRLVVDGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHT0</accession>
    <name>A0A011AHT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850941.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2654"/>
    <dbReference type="HOGENOM" id="CLU_056731_0_0_11"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458402" evidence="1">
        <location>
            <begin position="24"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="32373" checksum="991130E57E372551" modified="2014-06-11" version="1">MKAIALAAALLTGITLTASPAVANPAPSPTTYQLPAGFRPEGITIGREPVAYLGSLADGDILRVDLRTGRSKVIAQGPGTASVGLKLDQRGRLFVAGQSAGTARVVDTKSGKTLANLRLTTATDTFVNDVVLTRTAAYFTDSRQKQLYRVAIPRSGVPTRKDVTTIPLTGDIVYGEGNNANGITRTPDGRGLIIVQSNTGGLFHVDPASGRTTKIAVTKDGQEFPLTNGDGLLTLGQTLFVVRNRDNSIAVVNLDGTRGTVVGAITDPRFDVPTTLALYRGRLYTPNARFTTTPTPTTPYTAVSVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI82</accession>
    <name>A0A011AI82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851130.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2782"/>
    <dbReference type="HOGENOM" id="CLU_047691_22_2_11"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="31886" checksum="4F9E18FD0A69C6E6" modified="2014-06-11" version="1">MTAFDEYRDLLFSVAYRILGTVADAEDVVQDTWVKWSAADRTGVAEPKAYLARITTGLAIDRLRQRQARRESYLGPWLPEPVVTTEDTADDVSIALLLVLENLTPLERAVFVLHEAFGFTHAEIAEAVDRSPDTVRQAAHRAREYVSARRPTQRKGISRPTRARHREVTERFLAAAVGGDLNTLLDLLAPGVTLWTDGGGKVRQAMRPVVGAERVAAWFAGVGTRPYEGVDPADMTAEVLDLNGTAGVVFRGAGRVVATLTLDLDENGRIAGLHNVANPDKLRAVANRPSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIJ3</accession>
    <name>A0A011AIJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851268.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2903"/>
    <dbReference type="HOGENOM" id="CLU_066229_0_0_11"/>
    <dbReference type="OrthoDB" id="1751860at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="34128" checksum="365B43E8CCB7B7AE" modified="2014-06-11" version="1">MIWLSWRQFRGPAVVAAIALAAAVSGLVVLGVAIRREPYVRCTADCGALAAEFTDKWVNVLYFADAGLLVLPVLIGIFWGAPLVAREWEAGTHRLVWNQSVPRSRWLRGKLLVVGAASVVVSGLASVFLTWAAAPYDAVAGDRFTRLLFGTRNLVPVGYALFAVVVGAGLGLLLRRTVRTMAVTGLVLIAVQILVPTTLRAHFLAPEHRAVPMTAEVVANLRFLGSDATISGLTVPGAMVVSTSRLRTPSGELVDLGRYRACVSRSPETAPACIEALGVHVDVAYHPAGRYWTFQFLEFTLYLAAAAGLVALSVLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIM9</accession>
    <name>A0A011AIM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3364495_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="35" mass="3710" checksum="F7F49F61C5655047" modified="2014-06-11" version="1">MRRVVLRWVIAAAFAALTLLVSGGVAEAGLRINTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIV6</accession>
    <name>A0A011AIV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851468.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3035"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_4_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="29577" checksum="35B408F3EBF55D38" modified="2014-06-11" version="1">MRIFLAGGTGVLGRRIVPALLEGGHDVTVLARTPGAVVGAHAVRGDVLDAEATRLAVAEAAPDLVMHQLTDLAGGSGAANAALRVAGTRNLVDATRAAGVGRLIVQSIAWCYEPGATPASEDTPLDTGPAPDGIPAGTGPARRITVDAVAAMEATAREVTHAVVLRNGLFYGPGTWYWPDGSQAARARAGDLPATADVTSFVHVDDAAAAAVAALDWPPGAVNVVDDEPADGYRWTPVFCAAVGAPPPPRADAPRQGWARGATNAKARALGWSPRRTSWRDGFRPAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK15</accession>
    <name>A0A011AK15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851996.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3435"/>
    <dbReference type="HOGENOM" id="CLU_030571_3_3_11"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="27312" checksum="68A5FC53DEAD7684" modified="2014-06-11" version="1">MRPATGYAVYALQYGRRAGVRGEHFLGWDATSGERHDTAYYAWLVLSRDRTILVDSGIDPGAEPPLSGWEYRTSVPALLDSLGIADVDTLVLTHLHYDHAGGMRSFPTARVVVTAAELDYWNSPDAARNRREAWLVDKADLLYLADHRGITGDTEIAPGVSVHPVGGHTAGMQVVRVDTGYTTVVLASDASHFAENLDTDTPGNILHSMPGVYRAFDRVRELAGEGLIVPGHDPGVMERFPSVAEHVVRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKH7</accession>
    <name>A0A011AKH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852284.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3627"/>
    <dbReference type="HOGENOM" id="CLU_965470_0_0_11"/>
    <dbReference type="OrthoDB" id="1673802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="29608" checksum="0ABC6D4AB68DFE1F" modified="2014-06-11" version="1">MSDPAALRVLLGYDGSPAANAAIDAGARLFPGAHATLAYVWTPPFASDEMRNRLWAGAKNIDAFRAAVEREGSREATRLISTGIHLARAAGWDAEARLEAAYGGNGLELAQLAEELDADLVVVGSRGLGGTRAFLGSVSDVVVHYAPGPALVIPQPLLSAEYDALTDGPVVVGWDGSTGAAEALAAARTIFPSRQFVLVSVGEVDADAPELPGDADVTTLALPGRIGPQGRVVAEALSEAARAAGAAVIVVGSRGRSTVREMFLGSVAMATLHHAHRPVLVAAHRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKZ8</accession>
    <name>A0A011AKZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852555.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3800"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31168" checksum="469A9C2EFCD15673" modified="2014-06-11" version="1">MTTAKLSGWSGRTIVAVVLTVFVLFFAIPIVWLLLATTKSARGLIVDNPFAPGGLGDLAENWSSLFSFQDGAVTSWIGNSALYAIGALVITLVASIPAGYALALTEFRGRRLLLVLTLIVMLIPNTALVLPIFLELNVVGLIGSPLSVILPMSFFPFGVYLTYIYFSTSIPRDLLAAARIDGCREYQVFTKVALPLAAPIVALVAFFSFVQNWNNFFLPFVMLPSSDGYPAQVGLTSLLASTPAFNPSSAGAQSVQLPTLALATVVSVLPVLVVFLVSQRFLVAGMTAGGTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALM6</accession>
    <name>A0A011ALM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4000"/>
    <dbReference type="HOGENOM" id="CLU_004665_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="958" mass="101806" checksum="D1E65685613C502D" modified="2014-06-11" version="1">MRLVGAAGEHAVSGAKGRAVLAALGLRVNHVVPVDQLIDDLWADSPPATARNTVQVYVSAVRRGLEAAGSALRLDRLPAGYRLAGRREQIDWHLFETLSVQARRWTRDGDQPTAAELLRRALALWDGTPLADVGAGPLHDLFVPRMESARVSALSDRLAADLALGRGGLVGELTMLVRAHPLDERFASQLMHALHQDGRRAQALAVYRETRDRLVEELGVEPGERLRRMHAAVLADDRGLRPEPRDQPGVLGATWSGEFVGRHAELTELVALLARPGLVTLTGPPGVGKSRLAAEVVTRARAVRVVVVRLEGTATGGELVAKVADAVRATDTPIVDRLLGQSVLLVLDNCEHLAEACAQLVDQLLAGADDLRVLATSTVPLRVPGESVHRLAPLTLPGEVAGAADALANDAVALFCARARAVRPSFELSDAIAPAVAEICRAVDGLPLALELASARTAVLSPADIATRLADQLRVLRPVGGATGGRHGSLAAALAAAVDRLTPAERVLFARLAVFADTFPLAAAEAVGGPEALDVVHRLVDASLVVADVTGPETRFRMLESVRQYGRSLLDPADALDRRDEYLARLAADAVAEQSGPDRLRWQRRLDAARPDLLSALDRTLRGGRLELGLPMIADLRWWWSNSPRAGLEWYRLALRAASSGTVPAELLLRVQLTAAVVASYVTLPEAMEYAAAASVTATRLDDRPGMVRAAQHVSDIALELGDLETARRTGELAWRLAGESGDSFAIGRCGLSVAYNHFADAALDDAERWADEAAAVFARDEDEAGQADARLLVGEILLERGDLDRAEPVLSRVLATFRRHESFEQAARAAVLLAAVVGRDGRHSDAADLVREAFDRHGAIAHPWAVAHDLEVVAAEVAAGVARGGAGEARRAATLLGAAGAVRADAGLVPLPRDRRVRAEVEARSRTVLGDRAYRAAALAGAALDLPGAINLARAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALV7</accession>
    <name>A0A011ALV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4108"/>
    <dbReference type="HOGENOM" id="CLU_027853_6_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="31552" checksum="C082CF2D1A5D3C93" modified="2014-06-11" version="1">MIELGLHIADFTWDSGPAQLRRALAEHVREAEAAGVTRITVMDHFWQIQGVGPAEHEMLEAYTTLGFLAAHTEKARLSTLVTGVIYREPALLAKQISTLDVLTGGRAGLGIGAAWNEDESRGLGFAFPSVTERFERLEEALRICLQMWSDSEEPFDGKWYQLGRTLNSPQNLQSRPPIMIGGGGEKRTLRLVAQYADQCNIAGDAETVTHKLDVLRRHCDDVGRDYDTIEKTTIFGIDPTTTADDIVRDASAMRDLGFTAAYGYAHDVTDRKSIVDLFATAVPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALW1</accession>
    <name>A0A011ALW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4114"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458741" evidence="1">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="37"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="348" mass="37495" checksum="E9C3F176348D5340" modified="2014-06-11" version="1">MRMLRLLAVAAAATVLAACNSSSGGTSTDPVIGSDYPRSDTDFWNAYVRYSPQEAEKLGIKNLKTTNSENDVAKLTANVQTLLSQGAKGIVMAPQDTAAVAPTLQQLESKKIPVVTIDTRPDTGNVFMVVRADNRAYGEKACQFLGTKLQGKGKVVELMGDVASINGRDRTEAFDECMKKNFPGITVFAEPSKWDGATAANQLQTRLAAHPDIKGIYMQASFALSGTLQVLKQRNLLVAPEDPKHVFIVSNDGIPEELKDIEAGQIDATVSQPADLYAKYGLYYVQQAIAGKKFQPGPTDHDSTIIKVRDGVLEDQLAAPLVTRDGATIAGEKTLKFDDKTLWGNSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGH8</accession>
    <name>A0A010YGH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine-cytosine permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569605.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.365"/>
    <dbReference type="HOGENOM" id="CLU_026016_3_2_11"/>
    <dbReference type="OrthoDB" id="326558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="492" mass="51186" checksum="82A00E48D4007725" modified="2014-06-11" version="1">MSDAALSVEANGINQIAENERKGTPRDLFWPWFAANVSVLGVAYGSYVLGFAISFWQAALVGVLGIVLSFLLVGIISIAGKRGSAPTMTLTRAAFGVRGGRLPSFISWLLTVGWETSLVVVAVLATATILDRLGAGGGTATKVVALIVIVALVALGGALGFNLIMRAQRWITWIAGALTVVYLVFAADHVDFATVSGLPGGSTAAVIGALVFTMTGFGLGWVNAAADYSRYLPRSASTRGVVLWTTLGSSLPPVILLVFGILLAGSSKDLNSAIGLDPVGALTTILPTWFLVPFAVVTILGLVSGAIMDVYSSGLALLNVGLKAPRWVAVCIDSTLMLIGAIYVVFVANDFLGPFQGFLITLGVPIAAWCGIFVADILLRKADYAEAELFTPGGRYGDVRWTSVGLVVVGSAVGWGLVTNTMASWLDWQGYLLGPIGGKDGDWAFANLGVIVSLAIGFIGYLLLGRGAVRAQERIPAVTGSVVTNAQTEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGJ2</accession>
    <name>A0A010YGJ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="9" type="ORF">CryarDRAFT_0400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847959.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.384"/>
    <dbReference type="HOGENOM" id="CLU_018869_1_0_11"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="8">
        <location>
            <begin position="249"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="32671" checksum="076D2FD5E1B86210" modified="2014-06-11" version="1">MVGPPPAVAAVRVAVRGALRALPVGSLALVACSGGPDSAALAAAAAFEAPRAGLRAGLVTVDHALQAGSAERAAEVATWGTELGLEPSVAVRVAVGTAGGPEAAARHARYEALGAVAAEHGAAAVLLGHTADDQAETVLLGLARGSGARSAAGMAPVRGVYRRPLLDLPRALVHGAAEDLPVWHDPHNVDPAYARSRVRALLPTLEEAAGGGLVAGLARTAALLRADAELLDSLAAELHEDASADGGLTVRALADAHRALRGRVLRRWAIELGAPPGTLSAAHVDALDALVTRWRGQGSVHLPGGIRIARVRGALRRDDRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHL3</accession>
    <name>A0A010YHL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with SCP/PR1 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.778"/>
    <dbReference type="HOGENOM" id="CLU_1114360_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="25296" checksum="83223E12BD9D990E" modified="2014-06-11" version="1">MFGSTYGNHASRPDIYSGSRRRFTGVGTIAAGFVALVLVLGALLTSELGRYGTSDSPSDTQGTALDAPTPSPGAPDDAPPSADPAAPIAPAAPGGTPDGARPSGSPTPSKPVGPPAAGDATNRAVLASINKSLTSMGCDEVTYSATLQKASRAHLASMIRTGYLKLIGPDDSDPGKRARAAGYRRNVLEAIVLGAESPNEAARVGFTKSTDKTVRAQSSGALRCGYRAVGADMALDSRNVPITVIFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHX2</accession>
    <name>A0A010YHX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.915"/>
    <dbReference type="HOGENOM" id="CLU_069356_46_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25380" checksum="C7DBE52871D29978" modified="2014-06-11" version="1">MAHVWLAESAGSEPLRRLPSQQRSRQRVERILDAAGDLVAERGYEATTTSLIARRARVSPGSFYQFFADKRAAVKALSARNLAVFAERLDEALADDRFKHWWDTVDVAFDVYVDLCRHHPGFRAVRFGDIVDTHLLDPTQDNDSVVSSRIASLLHARFGVRDTPPLRLALLTTTKVADALIKFAFSRSPEGDEEVLQQGRRMLRIHLEGYVQVGGTTESAPGTTHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI42</accession>
    <name>A0A010YI42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015000_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28334" checksum="7EBB4EE2A94DC894" modified="2014-06-11" version="1">MEGIADYEFVRSLGDGNHGEFFLAKTPARLPVEAELVAVKVLSGSTTQEVFRRATRELSAFAAVRSEHLVTLYDAGQQGGVFYYSMEYLPDGSLAEPAYLLDESATLRAVAHAARAAHALHEAGIVHRDIKPGNVLLHPEGGKLSDLGLSQVLAPGMTLTGMGSLGSIEFVDPDVLHGEPPSRASDVYSLGVTLHYALTQQGLHGELPDHDPVLALRKVLSSPPSIDPGLDDSLAEIVSWTIAPDRTERPATALAVAERLEALVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIE0</accession>
    <name>A0A010YIE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848791.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1071"/>
    <dbReference type="HOGENOM" id="CLU_033540_2_1_11"/>
    <dbReference type="OrthoDB" id="895136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="394" mass="42287" checksum="008A09C4160B71D0" modified="2014-06-11" version="1">MPEKTTGERIRARRLDRGWSLTVVADRAGITASTLSRIERGLRGTNNRHLISDLAAALEWSVADLTGQPYVPADRQLEAAHARIANLRTAVAETTLELAPVDGHEPAPMAQLEQRAELVIARGIATDYAAVTDLAPALLIDLHAHAKAGNRRAAELVVNLGTPISPAFRYLGYLADSALLTERVREYAEWLGQPVPLAIADFLRANASAAIGFRRSAAIAEQARVELDRHTDEPGALDMLGMLHLTGAQSAVGQGRRGEALDRVAEARAIAERTGQTSTAALFFGPANVTVWELGLRVDADEPGKAVEVAAGADVTALPKIRQGYFWLDLSRAYTAMGKPQRERAVRALLTAERAAPQFTRSAPLARETARALRAAGGDSRDSALRGLCERLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ89</accession>
    <name>A0A010YJ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation/cationic drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849085.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1311"/>
    <dbReference type="HOGENOM" id="CLU_133067_0_3_11"/>
    <dbReference type="OrthoDB" id="1921902at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="113" mass="11514" checksum="A68B21347F104488" modified="2014-06-11" version="1">MNKWLLLGAAIASEVTATMALKAALDRPALYVVVATGYVASFVLLAAVLRRGMGLGVAYGIWGALGVVCTAVLSAVIYGEPLTLLMGLGIAVIIAGVLLVEIGSQAARAEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJB1</accession>
    <name>A0A010YJB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">CryarDRAFT_1364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849120.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1339"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21622" checksum="FCF0E74C888AE64D" modified="2014-06-11" version="1">MPFSSAPVPSGGGLDEQVYSRLLRDRIVFLGSEVNDSVANAICAQLLLLNAEDPERDIWLYINSPGGSVTAGMGIYDTMQWVSNDVSTVALGFAASMGQFLLCAGTRGKRYALPHSRIVMHQPHGGFGGTETEIRIQAEQMLHTKKTMAELIAQHTGQPLERIEEDSDRDRWFTAPEAQEYGFVDQVVRTLTPAGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJF4</accession>
    <name>A0A010YJF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569863.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1407"/>
    <dbReference type="HOGENOM" id="CLU_106319_1_0_11"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24855" checksum="18C56DFE3FCE7640" modified="2014-06-11" version="1">MITEHWPLYDLRITTPRLELRLPTPDDLAALATLAAGPIHDPARMPFASEWTDAPPAERSRSVLQHHWRSLAEWTPRKWTLQLVTVADDTVIGTQAIGGDNFAVVREVHTGSWLGQHHQGRGFGVEMRAAVLHLAFHGLGAREAVTGAVTDNPASLGVSRRLGYVPNGVVNRSMRGKPAVEQRFRLERANWRSPIEPITLTGVEPCLALFGIQASNVATDDHPAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJU2</accession>
    <name>A0A010YJU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase, diketogulonate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849445.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1567"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_11"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="27"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="32290" checksum="313C97055467A854" modified="2014-06-11" version="1">MPENTPALTLNNGVEIPALGLGVFQTPPEATRTAVSAALETGYRHIDTAAAYGNERQVGEAIADSGPARDEVFVETKIWISDYGYDETLHGFEKATRKLGLDRIDLLILHQALPSDFDRTLGAYRALEKLLADDAVRAIGVSNFMVDHLTALLDTAGVVPAVNQIEVHPYFQQREVQEFGRAHGILTQAWAPIGGITFYRESGHTSTLDDPTIGRIAKEHDKSPAQVMLRWHLQQGRQVIPKSVKPARIAENFDVFGFRLTDAELAAIDGLETGKRGGPEPTDVTLATFGRAIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM07</accession>
    <name>A0A010YM07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850493.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665184_0_0_11"/>
    <dbReference type="OrthoDB" id="1866964at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="413" mass="43980" checksum="1D1FB7EA944F5457" modified="2014-06-11" version="1">MAETVEAALARSLDRAAEAAPEPAPDLAAALTRRYHQRTSRRSSGRSRLIVVAAAFAVVVVLATAITAVRTIRDQHPPTTVADARALAFLGPAAPVVERADYPDGAAIDQVWPTAWGEVSGTPPIARFLPGGRVLTAGPESPIVSLDATTGAKRAISPAGQSYFAIGEPANAGAEKWIVWAVLAAGGRAEIWRAPVDGGAAARVTTLEPITNVRPTELRLTVVDDVVLIDPYPGVTGRGNVGVLWVPLDGSSAPALIPGSHDYRYLQWPWFGSTAVMNNSTIWNAVTGERLTTPLNWESMSCSRSWCVGREQNVVLVGRHDGSDVRKLALAAGRSTYRIVADRFVVGTFAANGGSMYDLVARKYLTLPPAARSEQWETAQLSGATSTNPFYVWTVTAPGRPTSLRVLQVGKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN49</accession>
    <name>A0A010YN49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAF family repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2705"/>
    <dbReference type="HOGENOM" id="CLU_054530_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458816" evidence="1">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="38001" checksum="30C4C45911626E89" modified="2014-06-11" version="1">MRLLISGAVAVALLAPAGTASAAPTVTATPLPVPDGTTNSVVSDLNDAGVAVGRADVDGTSRALRWDAAGYTALPAPAQRPGASAARVSESGVVVGSIGEPDVNQRSIRHWRPDGTTGDCPLTLWAPLGVEDANESGDALVGTVTSGRRFSATVCRADGGTVNTDLAVAHALSDDGRVAGARPGSSATNYNYVPTVLSAGGTATTLPVPAGQAGVAYDFGPGDAVVGALGTMRFGTGPSITFVPRVAVIWSGGRITELGTLGGDTSVPADTGRAVNAAGDVIGTSTTASGETHAFRWRAGTLTDLGTLGGPSSAPTAINDQGQVVGASRTAAGETHAFRWDDGELTDLGAPGGTASSAADVNASGVVVGTVTTTTGTQAVRWTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNT8</accession>
    <name>A0A010YNT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1892727_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14582" checksum="005744DE4D7785ED" modified="2014-06-11" version="1">MRAVAAMVAHSAHVEAGLLYVEGAGWEWAKLPALPATANVTFAAVFGVTPDEVDRTPVIRIEIEGPTKALGHVDHHFVVNTIHQIPGTPIHEPRVIELADLTFVEWGLHRLTAVRVEGSERQELAVVEFAIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPT3</accession>
    <name>A0A010YPT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851817.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="23663" checksum="4D0186BEE82EF3B6" modified="2014-06-11" version="1">MNETIRVLLADDDGLVRAAIDAILRPLAGIELIAQAADGREAVTLVQRHRPDVALLDIRMPNVDGLAALREIRRLALGVDVVMLTTFGEDEYVAQALGAGASGFLLKDSAVDELAPAIRAAAAGEAFLSPKVTRQVLNQLPATSAAPRSELARIESLSPRERETLVLVSQGLSNAEIAGRLQVSEGTVKTHVYRIYGKLDCDNRVKAAMVAQRAGLLDEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ50</accession>
    <name>A0A010YQ50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851995.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3434"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_11"/>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="440" mass="46860" checksum="E081051922B82E0D" modified="2014-06-11" version="1">MPAAENERPHASRTAARAAWIGSALEYYDFFLYGTAAALVFGTVFFPDEDPAVGTLVSLATFGVGYAARPIGALVLGHVGDRYGRRRVLMMTVIAMGAATFLIGCLPTYDAIGVTAPLLLVLLRLLQGFFAGGEQASANSMTLEHAPDHRRAYYSSFTLGGTQAGQAIATAIFIPIATLPDSALNSWGWRVPFWLSAVVAIVAVVIRRSLEETPVFEREAAEGEVPRIPMAELFRNHWRAVLRVVFAAVIATPSTIFTVWALSYAVNTVGLERTPMLLVGVLANLLALVTIPAWGKLSDRIGRKPQFIGGSIGSAVMTFVYLWTITTENYVLIFLAGILFFGAVYTATSAVWPAFYGEMFTAQVRLSGTAFGTQIGFAIAGFVPSVITAVAGDGRGSWVGASLITALLCVVSIVAVASGRETYRMPTADLGKPAKQGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQI8</accession>
    <name>A0A010YQI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="9">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852263.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3611"/>
    <dbReference type="HOGENOM" id="CLU_058969_1_1_11"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="15"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="26280" checksum="50D497000EBF6956" modified="2014-06-11" version="1">MTIGSVHSWDLSIGVDGPGTRLVLFTAGCPLRCQYCENPDTWHRRNGVPTTVEDVMAKVRRYRRLFDVTGGGVTITGGEPLMQAQFTGEVLAACAAEGIHTALDTSGFLGVRAPDEMLADVGLVLLDLKSWDPATYRKVTGRELVPTLAFAERLARLGRPTWIRFVLVPGLTDAAENVDGLADYVATLPNVERVDVLAYHRFGVAKYAELGVPYRLDGVPEPTGEQLEHARRAFASSGLIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQR4</accession>
    <name>A0A010YQR4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3702"/>
    <dbReference type="HOGENOM" id="CLU_067875_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="24570" checksum="76DD74B9651DC309" modified="2014-06-11" version="1">MVNADRLAVLLDREELFDLVRRERFARDQRLFDVMRDCFHDDAYVRTTWYDGHGGAAYVEATKAWMARTGNSKHWVFPAYARVAGDRATVESPAKIFNRTTVEGVEVDFHAYCRFFSRAVREEGRWTLLSFEVLLERDELRPVHAGEALPVDVAQLAGFRPSYRFLTWIQSTRGVTVSQDLLGDDRRAELDAFHRGETAWLTGTDSGQGRRPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQY5</accession>
    <name>A0A010YQY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852527.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3772"/>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_11"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="32494" checksum="7D113EB1513E0377" modified="2014-06-11" version="1">MDIGLVGVGRMGAGIARHWLKAGHRVVAHDLDRDALAVLARDGVEPVDDLDALVAALPAPRTVWTMLPAGAPTRGVTAFLEDALAAGDLLIDGGNTNFHESVERAGRCRDRGLRFLDVGTSSGLLGRSDGYCLMVGGDPDLAAETMPLLRAIAPDGGCRYVGPSGSGHYVKMVHNGIEYGLLEAYAEGFEVLKASDYSLDLPAIAELWRHNSLVQSRLLDLLARKLDEDPELSKYSDYVEDLGTGRWTVLEAIDKDVPTPAITAALLTRLRSRQDRSFGGQVLSSLREEFGGHVVDRPTGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRP0</accession>
    <name>A0A010YRP0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_21_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20112" checksum="3E0B5608A4C52FE8" modified="2014-06-11" version="1">MTKRYTRGELRRAQLLDAAVAVIAEHGLEGVTHRAIAAAAGVPLATTSYFFSSLDELVGAAVTRVADGILESADVLAEGAPVEHTIDLLVEVVTAPTVLVQFEAYLGRSRRPELVEPVRRIVEAYESAATTVLRSLGAPEPARAARHLIALLDGFALQRIAHPRPDDRDVLRDAVRLFARSYLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YS10</accession>
    <name>A0A010YS10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049704_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="214"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="35519" checksum="4FC0A4F1D2D184A9" modified="2014-06-11" version="1">MLEVYDTASLARHDRAEAIATRMREAAHAAVWEQPETGHEAELRLESCALGPLRLLNTRTSPHRAFRTRRHARGSSGAPVIALGVTLRGEGSQTQSGTEVPSVRNALYLLEMSAPFEHQRRTTTWAYTLHVPGDQLGLPLEAVHRARGALASSPLYRLMSRHLRELFRNQTALAADPAAARLGVATIELVRALVASAAHDRRHARSALDVVFLERVRFFVETHLADPDLTPAAIAAAHHVSERQLYKVCAAAGIRLEQWIIRRRLERVRDELADPAARHRTIAAVAYRWGFVNRTHFAQRFRAEYGLTAREWRALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YS17</accession>
    <name>A0A010YS17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725738.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4191"/>
    <dbReference type="HOGENOM" id="CLU_005511_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1199" mass="129947" checksum="A4CE60DDF596A88F" modified="2014-06-11" version="1">MGEQTTTERRDFFLSYTRADTETAQWIAWELENAGYTVLFQAWDMVPGSNWLRLVHQASRHAERTIAVLSAAYLRDSEFGEAEWLAAYQRDPRGLAGRVIPIRIEECVVDGLLAGVVHADLFDLPDRDAFRARLLSAVEAARSGRAKPLTEPPFPPGIVRGGAPGPPPPESPMPGTRSGYLMQIRQISPRALLDRQKELDALAAFCRDPAAGSYVWWRAAAWTGKSALMSWFVLHPPPGTRVASFFVTARYAGNSDRNAFLGVLIEQLSEVLGESVPPFQSESGQERLWFRLLDATAEHCARRGERLIVLVDGLDEDTSTPTSRATRSIAALLPANPPPGLRVVVAGRPDPPIPADVPPNHPLRDPDIVRILRRSPHASAIRADMQADLDRLRNGSLLERDLLGLVTAARGGLSGHDLAELCADHETTEWDIERLLSTVAGRSFTARAARWRPDDGRAVYLLGHEEIQLDAERSYGPRRLADLHRRLHTWADSYRARNWPPDTPEYLLRGYYQLLLLDDDGPRLVRYATDLRRHHRMLDVTGGDTAALAEVTEAQNSVRGSRVLDLARLAVYRTALIDRNSYLPRRIPAVWAVLGHPNRAEQIARAVLDPYTRWRVLAEAATGVWNVGDRAAAVRLLDEAEQAARRFLSADVLASALVTIAGHVTGTGDESRAVLLANEAEGLVGRISGHEYRAEATAHLAVSTAESGDRDRAMRLITTAEALLDDVTTPNHRAEPLCDLVRAAAEAGDPDRAGSLADRAERTIRCVGNLDERVDGLARLAHAAAVAGDESRVTRLAREAAENAPAIANSERPERTMYHVASALARIGEHRRAEATAAAIPAPGWQGDAQYEISRALLRAGDQVGAERVARGIGSVSGRAHALADIASAAASAGESERAELLVTHAEETARSEVDPYTRATGLANLVSALSEAGEETRAIRAAREAERAARDITDPEMRIWPLATLLAHGHSSLQVQLEALTEQTLNSTNGAYSRAGQTVYIVTQLTEAGQHSRAEAIARHIADPTFEARALAAISRQLADSGQPDRARLLAGEAESVVLTTTEELHGALALADLVLTAARVGDSHHAAQLAGVAEATAHTIAHSRSRSLALGSLGCALGDAGELDRAERIVSSVPNLDVQWWYLSRLGASVARAGAHERAEDMAARILNPDHRGWILAELAGALAEAGDHARAEAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV60</accession>
    <name>A0A010YV60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5926 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847431.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.56"/>
    <dbReference type="HOGENOM" id="CLU_075039_0_0_11"/>
    <dbReference type="OrthoDB" id="1424843at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="1">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="30875" checksum="F7A02F9BEEC017A0" modified="2014-06-11" version="1">MGKRGRERREKRVREVFVGRPFEGLATEAEWVALRELVPAATAPLKLADHPDRPVVLTTVLPMALPALVKPDGRIFLSVQMPARSGDLSRDLAAVLEDALRAEPGNYVGVAGLPEPGPRLQDLLADDGQLDVTVHETFDYWLDEPRPDDPEVASSLEQANSSILPTVPVTTAPAAYWCQVTEKAHLRWVLPEAEDTALDALARLQAAGDLALGSTGRYVGAFRAHGLLAPVWDLPHDPEPAEYEQPLADLAKRYADAVSVTDPLSAAERRARDGLRGRQLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVI4</accession>
    <name>A0A010YVI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3078951_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="52" mass="5687" checksum="909D7CBCFC0445D0" modified="2014-06-11" version="1">MYGNSIDSAYDVDRYLELAARIEWEEQGSVERPRPIETASAYALAGADHAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW89</accession>
    <name>A0A010YW89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848038.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.432"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_11"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="34016" checksum="6C97E1E9BAA38C76" modified="2014-06-11" version="1">MRVDPVGESKGGLLYLREGAQARALRYLHTTVQKTHTHSFFELAFVLNGEGVHVTPAGRDPLRRGDVVVLRPGVWHSYEECRDLRLYNLCFGPEILNRELAWCREDPGLGYLLWTGPMAMQRRGVLNALLTDPRLTECVDHLDALAELGSESSLTHRGDMLARLTLALSVVARAAREGEPAGPTHSAVLNAMRLLEERPAHPWTLAELADELHLTSGYLVRLFKSATGLPPMAYLARHRVEKAAELLLDTDEPVTQIGRSVGWPDQNYFARRFKAHFGVTATDYRGQFATNRAQLRTKSASDDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWV5</accession>
    <name>A0A010YWV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_10_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="27634" checksum="E17D09BD53AAA524" modified="2014-06-11" version="1">MFVGIATVDVVHRLERLVGPNEKVTALGQEISAGGPAANAAVTFARLGGHATLVTALGGHPLARYAADELAQHGVTVVDAAPDVTAPPPVSAIQVIDATGDRQVSSVNAGAHWAANPAEPPAGLPALVAAADVVLVDGHHPRLALAAARAGSTVVLDGGSWKPVLTELLPHVDYAVCSAVFPDAESLDVTHVAVTRGPDPVSWWSEGRSGRIPVPSVDVRDTLGAGDAFHGAFAYALTRGASFEEALEHGARIAALRCSVAGPRAWLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXT2</accession>
    <name>A0A010YXT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165306_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="23120" checksum="FF018A0B98C91069" modified="2014-06-11" version="1">MLSDVVAEQVNRARKRHGWNRGELAKRCRKLGAPQLTEAAITNIETGRRDADGRRRREVTVDELVIFGRALGVPPVLLAFPVGSQPTVEAFPGVEAPTWGAARWFTGEAPWGAWPDESGKRTAASEQDFQDYNQGATPIDLYRRHVAHYLSWAAASAEERGIQRAERPTRLGEEGTIRAIRKTMRQFGLTAPDVPEELRHLDADEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ02</accession>
    <name>A0A010YZ02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060579_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="26647" checksum="C8DB14964BEA7DC6" modified="2014-06-11" version="1">MTWVPPSSGESSRQPAGEPYDPPVPGSPPGYDAPGYDGSGYGGSGYGGPGYGSPAQGGPGYGPAGHGGAAPRSPAPGGPPHGVGTKAVSEREARRQRALRALPPPPSAPAGMGAVPAFAPPMPRPNRTVLIVSLVLGATLLLCCGGGVGGVGGLLYYTYENQRDDAVTAVQSYLGDLQNARYDQAYGRLCAEARSERSLGEFTEAEQVAGQVGSFAVSDQPQTDQDGNWVVAAQVTRQGNSVRSELFPVTFESGSTVSVCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ93</accession>
    <name>A0A010YZ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1594"/>
    <dbReference type="HOGENOM" id="CLU_069356_15_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23832" checksum="4E88877BA1C36C60" modified="2014-06-11" version="1">MHTVPRYGYPVPRVADHEARRRQVAEAVEQLIADDGYDGVTVARTAATAGISVGLVQHYFATKDDMLLHTFTVLRERVERRTMHDAEQAGQAGARIEHILVPALREMLPLDERRRRERRVLQAFAGRAVENPRLAEALRASNAHLEGVLAQAISNGKLCGEVVAAVNEADEAALLLAHVDGLAQLLYFDPERSAAQTALADHIHRLFPGPCHHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZZ7</accession>
    <name>A0A010YZZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849813.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1810"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="54017" checksum="40A3EA7285CBCB11" modified="2014-06-11" version="1">MTNSEPARPLLSLEGVGKTFGALRALDGVSLDLHPGEVHALMGENGAGKSTLVRILAGVHKPDAGVVRLDGEDVTFADPAAARDAGIAVIYQEPTLFGDLSVTENVFMGRQPLGRFRAIDRKAMRTQVEALFARLGVALDPDRPASGLSIADQQLVEIAKALSLNARVIIMDEPTAALSSREVERLFTVARTLRESGSALVFISHRLDEVYALCDRVTVLRDGKFVSSDPLADVTEDELVRRMVGRDLDALFPKLDTTPGEVALKVERLTREGVFTDVSFEVRAGEIVALAGLVGSGRSEVARCVFGIDGYDAGSVTVRGSALKPGRPAKAIDAGLALVPEDRRQQGLVMELSIERNATMTQLGGLARFGLLGGRAERARAKEWATRLQLKYRRLSDAVGVLSGGNQQKVVLAKWLATAPKVLIVDEPTRGIDVGTKAEVHRLLSQLASEGVAVLMISSELPEVLGMADRVLVMREGRLAAELDRTEATEETVLSAAVGRPGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0H4</accession>
    <name>A0A010Z0H4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2013"/>
    <dbReference type="HOGENOM" id="CLU_066193_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="135"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26942" checksum="C553FED790FC98B1" modified="2014-06-11" version="1">MAAFSDHSDVPVDIDMVPHSAVTLILDLGEESLVVADATGSRRDGCVVAGLVPRGARGRGPAGGFACLQVRLSPVVAHAALGGDLAGQVVGLDDLWGRDARRLHGRLRAAASWEDRFTIARTALAGRLEEGRAADPEVAYCWARLRRGRGHVRVERLAADVGWSRKRLWSRFRSQIGLTPKQAARLIRFDDAAHRLAAGRGAARVAAESGYADQSHLHREVLAFAGATPAAVATRPFLAIDDVAWPDRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0L0</accession>
    <name>A0A010Z0L0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csrA</name>
        <name evidence="3" type="ORF">CryarDRAFT_2088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850138.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2053"/>
    <dbReference type="HOGENOM" id="CLU_164837_0_2_11"/>
    <dbReference type="OrthoDB" id="2032250at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="80" mass="8611" checksum="EA10421080D5343C" modified="2014-06-11" version="1">MLVLTRRPGESVMVGDDVVITVLEVRGDVVRLGIRAPRSVPVHREEVFLELRAANQEAASSSEDAVQALSRLIGSDGEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0V2</accession>
    <name>A0A010Z0V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative stress-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850227.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143433_2_0_11"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="86" mass="9545" checksum="DE0E0EAE5AE48512" modified="2014-06-11" version="1">MHDVHRSLASHGLVRPREGRLLGGVLTGLGARVGLDPWPTRILFLLALAFVPGSWVFWAYFVAWVLMPSQEKQRSYTEPYAPGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z236</accession>
    <name>A0A010Z236_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570092.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_3_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="24450" checksum="5C18E9872B63AF6B" modified="2014-06-11" version="1">MSEGETPYVTIEQHPTGLVTWRERKKQATREALADAAWKLACEVGPENVRVDDIAAAAGVSARTFNNYYSSREEAIFAQRIRWAEEFLTVVHSRPGDAPLHDTIAGALLEVRGRREPDKATIRLVAATPAMQGEYLRHSVMTEFALAEIVATRTGCDQLSARVVGGAYALAIRAASEYWLRDDSDLPFTDFLRTALDRVAPAARGLEASVRASHPHREADSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2E5</accession>
    <name>A0A010Z2E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2677"/>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20052" checksum="B6717155847B11D8" modified="2014-06-11" version="1">MDAAERLVASTQELLWERGYVGTSPKAIQQRAGAGQGSMYHHFTGKPDLARAAIDRSATELRGLAEETFAGPGSAYDRIAAYLRRDRDVLRGCRVGRLTQDPDVVANPQLREPLEETLGWLRHRISGLIREGIASGEISSELDPDDVAAALVAVVQGGYVLARSADDPELFTRAAEGALALLGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2K8</accession>
    <name>A0A010Z2K8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851072.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2738"/>
    <dbReference type="HOGENOM" id="CLU_033347_2_0_11"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="9">
        <location>
            <begin position="207"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="34524" checksum="2A7409D757EF7473" modified="2014-06-11" version="1">MRVVMFGYQTWGHRTLKALLDSDHEVVTVVTHHPGGGVYERVWSDSVADLAAAHDVPVLLRDRPDDDELYEALRALEPDVFVANNWRTWIPPRIFELPRLGTLNIHDALLPAYAGFSPLIWALINGEPEVGVTAHLMDATLDAGPIVAQRAIGVGPKDTATDLFHATLELIEPILLDALAELASGRTDFPLQDRSKASFFHKRSEVDIRIDWTWSAEELERLVRAQSAPYPAAFCYHGTERLEILAADVSEAVYGGTPGRIFYREGDGVAIVAGADARRGRNRALLVRTVRTAEGKELSAPEYFTRMGGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3Z1</accession>
    <name>A0A010Z3Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3204"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458244" evidence="1">
        <location>
            <begin position="33"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="27599" checksum="FCECD3682AD82666" modified="2014-06-11" version="1">MFGRTTRRLAALATALLAVVSVVTLGPSAATATASAPKPTIVLVHGAFADSSGWNGVTARLLRAGYPVVAAANPLRGVASDAAQVKALLDRISGPIVLVGHSYGGAVISRAAVGDKDVKALVYVAAFAPAAGESGADLSAKFPGSTLADTLRPVPLPGGGEDLYVDRKLFHRQFAADVPARDAALMAAAQRPITSAALAEDAAGPQAWQSIRSYFLIAGADRNIPPRVQQFMAQRAKGVVRTVPRASHAVFVSQPGTTASFIIRAASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4L6</accession>
    <name>A0A010Z4L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851975.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3414"/>
    <dbReference type="HOGENOM" id="CLU_074104_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="5">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="95"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="28300" checksum="6372ECDEB34A1DAE" modified="2014-06-11" version="1">MTVSSRALGVLSDALRAQRNQRRTRWRKLSPGRQALLVVAHVRKGETHADLACGFRIGTSTVYRHIREALELLAAMAPTLAQAIEVARRKAFVILDGTLLRIDRVGMTSGYDRAFYSGTHKAHGLNVQVVADPIGRLVWISPPLPGARHDMGAAREHGIIDALATHEIPAAADTASQGAGPTVAVPQRRRRKDPGTGRYRRPSRNQKDVNTAHARRRGPGERANAELKNWRVLRKIRSSPNTAHRLIAAVQTLMIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKM8</accession>
    <name>A0A010ZKM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.219"/>
    <dbReference type="HOGENOM" id="CLU_665298_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="47278" checksum="563D0BB4F84053EA" modified="2014-06-11" version="1">MTARNSWVSPHHHGSHRDLLRPVRVSAPSNAHVDMIAVPTSRPVSYLAHAVRLAERLDCTLLVLASGKCSASEVVRRYGARLDDRLIVIDVPIGYAQSEPMFRFRADAVAPEVTTRPSDTSVKRNLALVLAKSLGVRALFFLDDDIIVPDWVDVCRAAAVMGRGHRAAGLFVDGYPDNSVVCHANRLTGGQQDTFVGGGALMVDAQQATGFFPNVYNEDWFFLLDSAADRAVATTGTAVQRPYDPFHSPHRARGEEFGDVLAEGLFWRLDLGDSVRGADAAFWKRALDRRLHFIDEVQERVGRMRDAPSLRWRIEASLEAATLAHHTFTPSICAHYLESWLHDRKGWNRRLARMPFGRPLGELLASLHLTLAGTADPGMRTIPAPTVVMSPDPQPLADSHGEPLWGLRSPLTVAAAGRRASVPSVDSSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLE4</accession>
    <name>A0A010ZLE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848190.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.516"/>
    <dbReference type="HOGENOM" id="CLU_069607_0_0_11"/>
    <dbReference type="OrthoDB" id="1745385at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="29888" checksum="EC35E1702CDB7E98" modified="2014-06-11" version="1">MTASIHRPGRTLRFGAEFARQLTRRRTQIALGFLIVLPLILVAAFKIGVPDDPDSAQEGNSLADLATSSGANFTLFSIFVASSFLLLVVVALFCGDTVASEASWGTLRYLLASPVPRGRLLRQKLTVGLAYSGFALALLPTVAMIAGTLAFGWGPLRTQLGVDIPAVEALGRIVLAVVYIAITLLPVAGLAFYLSVRTDAPLGAVGGAVMLWIISNILEAVTALGDLRALLPTRYGTAWLSLLSSPIEAEDMVKGAVSAVAYTTVFLALAWWRFLRKDIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLJ8</accession>
    <name>A0A010ZLJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848280.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.572"/>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="31"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29444" checksum="C60171B73EB41B6A" modified="2014-06-11" version="1">MTATLVATTPSSPVDEAPVRFGPVRTLRHSLTLTWRSLIKIKHSPEQLLDLTLQPIIFVLLFVYLFGGAVTGDRHVYLQFVLPGILVQSVAFASLGVGQSLAGDLQTGVFDRFRTMPIARSAPLIGAVLGDVVRYLVTIAVVLGFGAVIGFRIETDPFSTLAACALVLLFAFGLCWVTALVGLLLRNPRTVQGIGGMLMFPLTFGSNLFVPTDTLPGWLQAWVKVNPVTFVVEATRGLLTGQGAIAGPAVKVVISVAVLCAVFVPLSLAVYRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMV2</accession>
    <name>A0A010ZMV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1055"/>
    <dbReference type="HOGENOM" id="CLU_178607_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="74" mass="8136" checksum="1DC576221C667978" modified="2014-06-11" version="1">MTSMPRESMHRAELLALPPAVDLVTAARALNIGRTLAYTLAKRGEFPVRLLRLGVQYRVPRADLLTYLGEGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP32</accession>
    <name>A0A010ZP32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849329.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1491"/>
    <dbReference type="HOGENOM" id="CLU_039914_0_0_11"/>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="34257" checksum="3EA5F5258D3A2EE8" modified="2014-06-11" version="1">MSYSPVVPVSKKRRIGSVELLAGILIAVVVLRGPLITAFDSPAARTWATIFVSIVVQALPFLVFGVLISAAIAVFVPTSFFVRALPRRAALAVPVAGVAGVALPGCECGSVPIAGGLVRRGVAPAAALTFLLSAPAVNPVVLVATAVAFPGRPEMVAARFVASVLTAMIVGWLWLRFGRADWIRLPQRPDLSTTPKWTAFWLSVRHDAIHAGGFLVVGGLTAAFLNVTVPRRWLDALADQPVLAILALALLAVLLSICSEADAFVAASLSQFSLTARLAFLVVGPMIDVKLFAMQAGTFGRGFALRFAPLVFTTAVLISVVTGSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPK0</accession>
    <name>A0A010ZPK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein, putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.168"/>
    <dbReference type="HOGENOM" id="CLU_107144_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="17966" checksum="22D208A7A1CD13D8" modified="2014-06-11" version="1">MHSVGGEWDARPANRHDGHVQISARAEYAVRAMLALAANDPTTSTAQALADEQGLPRKFLEAILSDLRRGGLVRSQRGAEGGYRLARPADSIAIGEVLRVVDGPLAGVRGERPEAAVYAGAAQNLQTVWVAVRAAVRNVLDEVTLADVLSGNFPSHVSEMVAAPGAWAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPV5</accession>
    <name>A0A010ZPV5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849736.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1766"/>
    <dbReference type="HOGENOM" id="CLU_057862_2_0_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="30757" checksum="DC2F1E0F45D9DFD8" modified="2014-06-11" version="1">MDTRGLGAFLRAQRARLQPSDVGLPAGDGRRRTPGLRREEVAELSGVSSTWYTWLEQGRPIVASGQVIDALARALQLDPDRHRHLRALAGLAPPRTYTSGREATPRLQHLVDNAAPNPAVVYDRYFDYVVWNDVYARVRHDPATQPPNRRNAVWMMFTDPANRARQQCWAPAARALLSRFRTSAGQRPEDPRFAELVDALLEASPEFREWWPDYLVRDFRPTVLELDHPDAGRLVLDLYQLRPVEFPDLLLIVQIPATSDDRQRIERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPW0</accession>
    <name>A0A010ZPW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endopolygalacturonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849744.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568282_0_0_11"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459201" evidence="5">
        <location>
            <begin position="28"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="480" mass="50467" checksum="1D99FA7FCA45F6FE" modified="2014-06-11" version="1">MNYLRRIIVAVALLAGAMAIGPLPASAATVVTYPAPSGAPGTGQYSVQVAGRPSFVHPTGLGAFTNFSFGGGPVTVTVTTSKDSRTPVLRPRDAAVGVTRVAARTFRFTIPVAGSYSFEIDPDTDGYPPLFLFANPLETNPPTGDTATTKYVGPGYWTVNSSGQIVPGSTGVAGTYSVAPGTRLYLAGGAILRGKIRIGSDSEGGAGADGTAVTGRGIVDSTAVVDHGRPLRINNSTGVTIDGPIFLGQKHWGVVARKSQQVTLRNIKVINWRDDDDTGTPDGIDVVASSNVEVDGAFVRSYDDGIAIKSSMSDDTWMGPTSQIYVHDSVVFNGRAGNGLEIGRESGASISGVFYENVDIIHKLARSDPYARDAISIFVRDEGDVRDVNYTDVRVEECQERYLGFEVTGPGSLTGVDVTDVTFAGAPRALPTVITGNPNGALDDVAFRGLRFNGGSTLVTRASQLTFVTNQYATRVTFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ41</accession>
    <name>A0A010ZQ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849833.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1821"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="31738" checksum="5F7B5DC0BAB9BD61" modified="2014-06-11" version="1">MVDSRRRHRALEILFLVPAVAYLVLFFGYPIVKNLTMGFQEYTTSTFYTGEAPWVGFANYSAVIGSSVFGKALLNTAVFTVASIAGQFVLGLGIALYFRRRFPLSGLLRSLILLPWLIPLIVASAIWRWILDQDNGALNRVIPGSPGWLTSTSLALIACIIVNIWIGIPFNTTILYGGLQDIPPDLYEAAALDGATGWRAFRYVTWPLLRPVVNVVLVLGLVYTIKVLDLILGLTRGGPANATQTLATQSYQLSFVEFDFGQGAALGNILIVISLVFAFVYLRSARREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ79</accession>
    <name>A0A010ZQ79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847929.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.371"/>
    <dbReference type="HOGENOM" id="CLU_060077_0_6_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="29051" checksum="3BEE03DB63635957" modified="2014-06-11" version="1">MSWSVGQVAKEAGVTVRTLHHYDEIGLLTPSERTNTGYRRYSYVDLERLQRILAYRQLGFGLEEIAAILDDSSVDPIDHLRRQHALLTGKIEELQQMVAAVEKTMEARKMGVSLNPQEMFEVFGENDPTQYEDEVRDRWGDTDAYRQSQRRTATYTKDDWLAIKEEAAGNLADFQRLFLAGVPADSPDAMDVAEAHRQHITRWFYDCGYDIHRGLGTMYVEDERFTRHYDTEKPGLATYVRDAIHANATRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ81</accession>
    <name>A0A010ZQ81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847945.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.376"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="249"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="44291" checksum="009580458D618ABE" modified="2014-06-11" version="1">MDFEPSPKAQEYIDRLTAFMDSHVHPAEPVYESQREELIAAGQPHALPPIVEDLKREARARGLWNLFLPDVSGLTQLEYAPLAEITGRSPQLAPEAINCAAPDTGNMELLHLFGTDEQKKQWLEPLLDGEIRSCFGMTEPDVASSDARNISTSVVRDGDDYVINGRKWWTSGAADPRCKVMILMGKTDPDGPTYAQQSMILVPMDSPGLEVVRDLSVFGYHDQHGHCEIRLTDVRVPVTNLLGEENGAFALAQKRLGPGRIHHCMRAIGMAERALDAMCRRAVSRVAFGKELARQGVVQQWIAESRMAIEQARLLTLKTAWLIDKKGFQAARTEVAAIKVVVPQMAVSVLDKAIQVHGGGGVSGDFPLARSYAGLRTLRLADGPDEVHIMSVARTELAPYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ91</accession>
    <name>A0A010ZQ91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">CryarDRAFT_0402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M41.015"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.386"/>
    <dbReference type="HOGENOM" id="CLU_000688_16_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="731" mass="78684" checksum="8F0D4B4231390D13" modified="2014-06-11" version="1">MERTRFIRRPLVWIILMILVALLLGSLFTGDGDYKKVDTSVALAQVREGNYNKAQLQDKEQILRLELKNDYRGDKKIEASFPSQSADDVFSLLSEKSEANGGPAFDTKVTQESIFVTLLITVLPILVVVVLLFLFMSQMQGGGSRVMNFGKSKAKLVSKDTPKTTFADVAGADEAIEELHEIKEFLQNPAKFQAIGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKQNAPAIIFVDEIDAVGRHRGAGLGGGHDEREQTLNQMLVEMDGFDVKGGIIMIAATNRPDILDPALLRPGRFDRQIAVDRPDLEGRKAVLRVHAKGKPFSPDVDLDTTARRTPGFTGADLANVINEAALLTARLDRKAITNESLEEAIDRVIAGPERKTRAMSPKELKVTAYHEGGHALVAWALPHSAPVHKLTIVPRGRSLGHTLILPTEDKYTQTRSEMIDTLAYALGGRAAEELVYHEPTTGAGNDIEKATGMARAMVTEYGMSAKLGAIKYGTSDSEPFLGRDMGHQRDYSDSIAAEIDAEVRALIELAHDEAYEILSEYRDVLDTMVLELLEKETLSKDDMARICARVQKRPPMSPFNGFGKRAPSDKPPVMTAAEVAELQKKAADEATARLANGSNGLRANGGGAHAAPDDEPGVSINPGSDASVPAPGDPLNDPLPPQSDTLGGPQHPGQPGWPGTGHSGSSGPGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQQ6</accession>
    <name>A0A010ZQQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850161.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034172_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13533" checksum="D4CAA964BBF1A88B" modified="2014-06-11" version="1">MPTFRVTRYVLSYGAVKTAGERPFPWHSIILVFDPDGRPPISDAVVLFTPSNSLGNMNTPNRLTAYLPVEDFDTYHRILQTESPVFAEWTEDNGGRLTSFYLKTQEEPVGEGPVDRSEGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR76</accession>
    <name>A0A010ZR76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848479.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.738"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="23342" checksum="67012F4A7A4E65FB" modified="2014-06-11" version="1">MRVVLAEDLALLRDGLIRLLTAYDFDVVEAVDNAPSLLRALITHRPDVAVIDVRLPPTFTDEGLRAAIQARTEIPGLPVLVLSQHVEQLYARELLSDRAGGVGYLLKDRVSHVGQFVDSVRRVAAGGTAMDPEVVSRLLARHSADEPLGRLTPREREVLSLMAEGRSNAAIASRLFVTEKAVGKHINSIFGKLDLPPSEDDNRRVLAALAYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRM5</accession>
    <name>A0A010ZRM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850523.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137402_0_0_11"/>
    <dbReference type="OrthoDB" id="2083224at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15501" checksum="8513E9EE1E3ED156" modified="2014-06-11" version="1">MNAEDVVSRLDRRLSLRRRVATVAVALAGAAVAAVVLALWATEPHLPARTQVAFGVIAAGGLGWVGYGAWVLRRRTPLLALDRVVAGWLALAVTIAVGLTVTAIALSRGRGEFTVLAGAFVLVAAINVARARAYRGKLLRRKRELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRW8</accession>
    <name>A0A010ZRW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2469"/>
    <dbReference type="HOGENOM" id="CLU_078449_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="31475" checksum="ED00BDF4DECF3E29" modified="2014-06-11" version="1">MPPARRFGTATLAVATTFALQRAAARLPASISDALARTNHRGEPVTLAEGPVTALGATLAAVIGVAVVAPRVAAAAGVAGLGAAAVGAYDDVVGARPDQRTDKGFRGHLDALRAGRVSAGAVKVAGIGASALVAGALLPRSRSPLGAAADTVLAATVVAGTANVVNLFDLRPGRALKVGLLAAAPLLAGDRNGSAVVASAVTGAAVTALPDDLGERSMLGDAGANALGALLGVAAAARLGRTGRVLTAAGLIGLMAASEKVSFTAVIARTPALDALDRWGRRPPAAPTTEPAAGVPTAGEPAAEVTAAPTSSRTGEPGHAAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS62</accession>
    <name>A0A010ZS62_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848833.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1098"/>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_11"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28609" checksum="FD06683D20EFE320" modified="2014-06-11" version="1">MTTARPDVAVIGGSGLYALLDDVDEVTLDTPYGAPSDPITIGTVEGRSVAFLPRHGRDHRYPPHLIPYRANIWALRSLGVRQILAPCAVGGLRPELGPGTFVVPDQLVDRTSGRVQTFHDVGAVHVSFADPYCPTGRTTVLTESTEVSPVDGGTMVVVEGPRFSTRAESRWFSAQGWSVVNMTGHPEAVLARELAVCYTAVALVTDLDAGVETGEEVTQEEVFRVFAENTDRMRALVLRAAAALPEERDCACSHALDGIKLAFDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSF8</accession>
    <name>A0A010ZSF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013384_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="773" mass="81559" checksum="7057BC4E6111E19B" modified="2014-06-11" version="1">MSDRLVPGTVAQDALEVSAARIALIFRVAWSALTPALAYPQALAAGGVHTWQHVAIVSTVAWGGAYAWFLRGGRLVPAVAVADSALFCVYLGFAPWILPAEYVGNPSTWIIGGASVALFIASWALAPLWTIALAVAQSAAFLVGVVAAGLPPVGGHDSVVAIFVLQGFLAVVVMRLIRGGARRADATLDHVARARAELTIERSRLHSRRQFERNLHDTVLSTLTVVARGTLRTRLDLVRARCGRDVAILDRLDELPRSAGLFASITWESGCRAMPVRLTLPEDEPALPPDVIEAVAGAVREALSNVERHARADGAEVSATIAGSGIRIVVRDDGQGFDPATTTTDQTGVRRSIHERMGTVGGQAEVASAPGAGTTVTLTWQPAERTGAPTPPEPDEPSVAAGYRAGMGWALVVIAVVWHLYSSSSLATRPDAFEPFWLELTAWVAIGLVVLGVAVRGPARPLPGPVNLGAQLVVFAAAVAGFAAMDGVDQISANWITGDVGWPLALLALHRPVAEYLAWSAAVVALSVGVVLVETGPDTGAVTRIVTALLCALVLQLAAVVAFGLVRRNGALAEAGVREAGRIRETRDALVAVADDRRRWQRELGESLRPLVGALADGRLDPGDPDVRARCAIEASRLRAMLSELTETGEHSMWRRDMVSSLSGAAADRSATIEARIAPDFGEVPEPVRAELVAAVLAILRLTSPGEAVVTLSGCVRDASATVLLPVASERPAVKEAMWTLLHRVRAAIPGTVSADVEEPGSSKFWVEVRWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSL0</accession>
    <name>A0A010ZSL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849008.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096009_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="19318" checksum="C80713ADF87B6F74" modified="2014-06-11" version="1">MARTLSTAADRRETVLGTAIGAFAAKGYFGTTTVEVAKAAGISQAYLYRLFPDKQTLFAAVVGRGFQRILDSFRDGATGDSPEAILYSMGGSYAQLIADQDLLLLQMHAQCAAVSVPEIKRAVREGYATLVEYARTASGADDDAVQEFFANGALCSIVVTMDSAEVDAPWARVLDNGLRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT44</accession>
    <name>A0A010ZT44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851319.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2945"/>
    <dbReference type="HOGENOM" id="CLU_024435_3_1_11"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="427" mass="45246" checksum="6A3702041B3A5EC8" modified="2014-06-11" version="1">MITSVGRVVVAAGLAFVAAVPDAESPRVETSGALTPTIVRTLPGTASAPFDRVRRLQAPPGWTVTVWARVPSARLLAWTPDRRLLVSRPEFGDVVALTPGRSAPTRRTLVSGLNKPHGLAFAGSTLYVAESDQVDAFTYRAGALTGKRVVVDDLPDDRSPELRGQYSHELKSVAAGPGGALYVSVGSTGNISAADRSAHPERATILRAVPGGRPTVFARGVRNGTGLAIAPDGAVWTAVNSRDQVAYPHDRDLDGDGRSDLGAVLQEYVNDHPFEPLARLTRGRDLGWPYCNPEPGPGYTRRPFVRDVQTNPDGAKLDCASLPPVEQGVGAHSAPLGLSFAPEVGDLGPGALLGLHGSWNRTPPRAPEVSFFAWRGGTLGAQQTLLTGFQLPDGSRWGRPVMAVRGPDDALYVSDDKADAIYRVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT99</accession>
    <name>A0A010ZT99_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">CryarDRAFT_1516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849325.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1489"/>
    <dbReference type="HOGENOM" id="CLU_066632_1_1_11"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="27477" checksum="8F1441926401795D" modified="2014-06-11" version="1">MPLYRDIGVVLRVQQLGEADRIITLLTRRHGRIRAVAKGVRKTKSRIGGRLEPFSHVDVQFYEGRSLDVVSQVETLDPFGKYLVDDYTRYTTASAIAETAERLTAEEREPALRLHLLTVGALRALTVGEHDAPLVLDAYLLRAMSYAGWAPALMECAVCGLRGAHRAFSVQAGGCVCGNCRPPGSASPSTEALELMVALLDGDWNHAGRTEPPTRREASGLVAAHLQWHLERGLRSLPLVDRTNVGENFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTC2</accession>
    <name>A0A010ZTC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative epimerase, PhzC/PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1520"/>
    <dbReference type="HOGENOM" id="CLU_098567_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="23943" checksum="FDB53EFA52554A9D" modified="2014-06-11" version="1">MLSGMSIEVHELLVFPGPDGTAGNPLGVVLDGASVLRADRQGVAAELGYSETVFVDDAATGAITIFTPAVELPFAGHPTVGTAWLLAREKAPVDALRPPAGTVAVRYETDLTWVTARPEWTPKFDFRQLGSAAEVENYPLPTEGQQYVWAWIDEAAGIVRSRSFPVDMGIQEDEATGAAAVALVGKLGRRVEIHQGVGSVLIAGPTGDGAVELGGRTTAVRRLELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTH1</accession>
    <name>A0A010ZTH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851515.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1657912_0_0_11"/>
    <dbReference type="OrthoDB" id="2088524at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458410" evidence="1">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="17050" checksum="E3FECA3542ACCD0D" modified="2014-06-11" version="1">MIRRLAGAALVLLLAAACTNSDPKPAPTPTSTLSARSPAAVENAVAALAETLRTDLGATQPLSDEQPRAQACGDEDDGPFNVFVSYQLPLPTAEHRAALQRLRDHWTTAGWTTVTYRPFADTRAELTGVNPDDYGVRILSGNPPTVLALQITTPCYRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU32</accession>
    <name>A0A010ZU32_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1769"/>
    <dbReference type="HOGENOM" id="CLU_240134_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="1655"/>
            <end position="1802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1812" mass="191454" checksum="AEA94AFF311C9AE3" modified="2014-06-11" version="1">MGGFVSVPDVIGDRSTGSRASEGAPRIPGLVLLGEIGRGNDTVVYRARRDGPDVESIQQYAVKVLGLAASVGDEARHKFRREAAVLACVDHPGVVRVHAVGEVDGRPYLVMELVEGRSLAEVLHGGQLDQASAAVLGAAVADALAAAHRVGLVHRDVKPHNIMVRSDGRPMLIDFGLIDFGPAAAGGDAPGLGIRPSGAIAGTLTYTSPEQCGLLHRPVDGRSDLYSLGVVLYECVTGRPPFLAPDIGELMHLHATTAPPDPRMFRTDLSGGFVSVLGRLLAKDPDDRYPGALAVADDLRRLLPDAAPPSAGVVPSGIDARSPLPLVGRERELAALLGYWRRTAAGTASLVVLEGAPGIGKSRLAEQLVVEVRARASGRPGPVILTARATDGAAPLAGLRTAIDQYVRTVERLPDGARAEAHHWLTTAAAPVATLLQPLSPALAGMLGLPAPVADDSGQHQFPAAVATFLSELARCAGGLLIRVEDAHVLDSASARVLAQILAERAGNPVMVLATSRGVANATSLIASAEMQTLVDERILLGPLHPTAVAELVERLSGRMDLGREFAERIATATDGNPLAVLQYFRAAVEGGLIRPSWGRWIVDLDGLASVRLPTDVVAFLIGRLEQLSAPVRAILVVAAALGVRFDPGMLSAVSGASAEDVRVTLDEAGRLRVVERRGGGDYGFVHSGIRRALLRGGDRMYLRAVHQAAAELLTPRDFTGPVDPGRIYAVARHRMNGQVERNPGAVVQACADAARQALADYSPIDAVGYADEAERVATTYRLPLPYRFDELIGLALHQSGRYAEALDRLGSAIDRADDPLDRGRLLVDVGQVHLSRWDPTAADHAFSWALSVLGHPLPRNRTSLALSSGLSALVAVTRMRGGRTTGTTTGPERERNRLVAKALVGLAHSAQFGMRPRQVPTYALRALLPVARIGPTPEYVGVFGLLGMASAATGRRRIARRLFARAHQAADALGQPQLTAQTALQEQDARYLIGDNAPDRAAALLGERGQWLDLFLYLNGTAVFCWQRLVRGDVVTALAAYRGGAQRLTLSDEDDPAFALVGAAVTAACGRLTDAHEQLAQLRELVAAREGDVSGLRVNTAMTETQVAVESGDLGERFDATLDWFARMGLEPGALLPIQRTVYVYQAYGRLEQCRRDRHRRRAEGGEAQGVGMRDEKLDAARRAVADLAAAARGRSLQAHALVAKAELIRLEGNPAGALEAALAAAGPIRTASSALAEYEAARVRARALLALGDPGAARRAARDAIDLATEHGWPHRSDWVRLEFELVGESPVGTYDPDWDISRSAADRERLAALEQVSKAAAGELDLLGLARVGLDESIKILRAERGLLFLMDDETGRLELWLGRNARKEDLIQPGGYATTLVDRVRMTRHELVITGPEDGAALGSGSVLEYGLRSVVVAPLELDGHLLGVVYLDSRVATGVFRPKDAAILTAICTHVAAALETARAAEFAAGVRAVQQEQKTADLLRIAMTSVSGTLDPAMVLMRIHNALRAMLPGDVSWLVERDADGTLRLSGEAGFEQVKPETLKLLLTVDSPLVVPIDGPSSLLVVPLTIAENPPARIGVVLLAADGEDAFRDSHLGLAEALATHGMTAYQNALLFQEVTRLATLDGLTGVANRRHFYEEAGAIVEAGGPTAAIMVDIDHFKQVNDGHGHGVGDQVIAEVAARLKRVLDSGGWLGTGLAESGPAGTAAALGRYGGEEFAVVLGGAAAERAARVASGLHAAVREQPVETDTGPLPITVSVGVYSAAGTDLSALLGSADEALYAAKRGGRDRVVVGNRTLPADAQDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUF3</accession>
    <name>A0A010ZUF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851991.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3426"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="243" mass="25878" checksum="FBF530B842EB2310" modified="2014-06-11" version="1">MTQTVTATDDLVVEGLSVHYGGVSAVRSVDLTVPAGTAVGIIGANGAGKTSTLRAIMGLVPRTATAMRWGSVDLTKVPARDMVRRGVGYVPEGRHVFSGLSVEKNLLLGAYSRPWRAETKQVLDEVYDLFPVLGEARGRLAGALSGGQQQMLAVGRALMCRPRLLLLDEPSMGLSPKLVGEILGVLQRLSAEGLSLLLVEQNAKLTFEATSTCLVVENGEVAMVGTSEELRHDPNVRRIYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUH1</accession>
    <name>A0A010ZUH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1901"/>
    <dbReference type="HOGENOM" id="CLU_129731_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="12170" checksum="ADF44FA056486095" modified="2014-06-11" version="1">MSFLRRKKTRPGTPRGAQREDIAHLEEFARTRRGVEAYVEPQTNVTAMTVILIATDGEWTRRRIGSPDDARKLGQRLGMPVYDVAAVGYPNRMREWSRKKAAGPDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUH4</accession>
    <name>A0A010ZUH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NaMN:DMB phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="38735" checksum="AB54775A01876DF8" modified="2014-06-11" version="1">MTDPDAESAPPPESSLLESLTPVAPEWADGEAAQARLAGWGTATGALTGLAHWAGSVRSVDTPFRRVRLIAFAADHGVTDGAAEATALLAGEGALALLAHRADVSIRVVDAGLAGDPLPGDVSARRVRAGSPALNREDPLTPDEVEAALDLGARVADEEVDSGADLVIPVVLTASALVPATVIIGSLCVVEPVRALGYDAHMPDALWIERCAAIRDGMRRVSQAAATLATRRLLATGGGADLAAAAGFLVRTAARRTPALLDGVGVAAAALVARALAFEAPRWWCAPHASGRAGEKQAFSSLGLEPAVDLGVRLGDGSGALLALPVLTAAMELVRAAPHPVVESPDEVEVTVDPGDEIGGVGGYDAGARPPEVVDDQAAPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUN1</accession>
    <name>A0A010ZUN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852173.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3539"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_11"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="24399" checksum="D32FDF4E79DC96B0" modified="2014-06-11" version="1">MPIPEDVGVIARPLLRENAYRSIRDAIVDGTLAPGERLNDAELAQWLGVSRTPIREALTRLEESGLVQTKPGRYTIVSPLDTRAARAAQTVTAAMHELAVREAVPHLSSAEIEAMRQANVRFAGALRADEVDAAIAADDEFHNVAVTACANPAVRTVLEQFTPVLRRLERLRFSSLIGRGSVATHDRIIALCEAGDAEGAAAAARDNWLSLSEVFDVDDSDAPRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUY6</accession>
    <name>A0A010ZUY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="32799" checksum="A7C2787CD169FBEF" modified="2014-06-11" version="1">MSTTQAARAPVAARLPHLLVRLVYVAPVAMFVVLVAVLPEVLSRTGVMSLLVLAALLGIAAVGQTWAVMIGGIDLSIPATIGMANVLLTTLYSRGWSFGAALAVIVAVAVATGLLNGALAGSLGLHPLVVTLGVGSVVTGAVLVATGGNTGGAVPAALTDAVSPVGTAGPLPIPFAVLAWIVIAGLVLWVERRAVFGRHLYAVGANTRAARLAFVRPVRVQITVYVVSALCAAATGTLLAGSSGGASVGIGSSYLFSTITAVVVGGTSLLGGAGSYARTIAGVLVTTEFTTLLIGVGIGATMQQVLLGLAILALITVYGRDRHVAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVQ8</accession>
    <name>A0A010ZVQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850556.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2355"/>
    <dbReference type="HOGENOM" id="CLU_509747_0_0_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="3">
        <location>
            <begin position="368"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="518" mass="55195" checksum="F0932C3A381EDA31" modified="2014-06-11" version="1">MTDYGHDLVFGTFLTPSAEDPGRVVALAQLTEQLGFDFATVQDHPYQARFLDTWTLLSVIAARTTTLRVAPNVVNLPLRPPAVLAKSVASLDLLSGGRVELGLGSGAFWDGIAALGGRKLSPAQGVDALAEAIGVIRALWAPGGSVRLDGEYYPVRGAHAGPAPAHDVGIWLGAYKKRMLALTGRAADGWLPSSPYAGPEKLPAMNAAIDAAAADAGRDPREIRRLYNITPQFTADQLAELTLEQGMSGYLVMGDDPEVVRRFAAEVLPAVKAQVDAERARRAAAPPSSAANTPPAASTPGIEPAATGTVASRSGRPLPTGLGVTPTPDDGVRLSGVTLWDETERPTGPAPDPGRAYTAAQRASGQHLIDVHDHLRSELATVRDLIEQVAAGLTDPGAARSAINAMTMRQNNWTLGTYCESYCRVVTTHHTLEDTALFPRLRRADAGLTPVVDRLAAEHVVIHDVLERVDRALVGLVTDEKDIDQVRAEVDLLSDTLLSHLAYEERELVEPLARLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW70</accession>
    <name>A0A010ZW70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850802.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2540"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="266"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="516" mass="56025" checksum="B9CB4DC7612EBFB1" modified="2014-06-11" version="1">MGEPTPAEKPILEMTGVGKVFPGVVALADVDLRLYPGEVHALMGENGAGKSTLIKVLTGVYGIDAGSIRLGGEDVRFTGPLQAQRAGISTVYQEVNLCPNLSVAENIFIGREPRRLGAIQWRRMRRRSAELLRGLDLDLDVTALLGSYSIAIQQMVAIARAVDISAKVLILDEPTSSLDASEVEQLFAVMRRLKREGLAIVFVSHFLDQVYDIADRMTVLRNGRRVGEYRVEELPQSQLVSKMIGKELAVLEELEEQQKPSTAALEQGQPVLAATGVARKGAIEPFSLTIHQGEVVGLAGLLGSGRTELARLMFAADKADQGTFSFGGDTVPMRGPRTAMEHGVAFSSENRRTEGVVGELTVRENIVLALQASRGWARPIPRGRQDELVAKYIKALDIRPANPDTQVRNLSGGNQQKVLLARWLITEPKLLIVDEPTRGIDVGAKAEIQRLLAQLSGDGMAVLFISAELEEVLRLSHKIAVLRDRRLVEQLDNTDDVDVDRILATIASGSATGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWE1</accession>
    <name>A0A010ZWE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_11"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="172"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="425" mass="43281" checksum="2F43EF1D2792AD83" modified="2014-06-11" version="1">MSFTLVSDFHGRQYRVGENATDLTGRSRAWMLRASLAAMAAAGLLQYGLAAALPALARGNGWSSTDVLCVLGLWVAGQAGVAAPATALYRRAGTRLLFPAAVLCAAGLATPAHTGSLTLVLLGYSVLGGLGAGLVYVVCIGVATEWFPERIAGVTGAVSGAFGYGAVPFVAVVYVVDAGPILFDVAAVLVAVVVTGAALVVRRPPERWWPAGIDPRLWALDRRLNRSIPANAPAIRSYRPADAWRSGMLPLMWALVGVIAAMALFDLGYLAVSGSTAAIGVLALATGLARVVTGRLSDRLGRRRMLMAALLLGGLAQFGLLAGGEPGPVALSAAVAGVGTGAGYSLLVGLVRDWFGDEATLVNYGLVYTGKAVGGVVGLLLVAASSPARGEIVAVVVVGALGVLGACAAGLLRRPGRPALRLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWK8</accession>
    <name>A0A010ZWK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD, TfdA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850996.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2686"/>
    <dbReference type="HOGENOM" id="CLU_041041_2_0_11"/>
    <dbReference type="OrthoDB" id="1742732at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="70"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="40064" checksum="0E37A633614F0BAE" modified="2014-06-11" version="1">MASTTLSPVTGPSAWRGDQLQHDRSWIYHLTEEQIAELEAVGRKFVLDDPDLRTVTREDYPLPVCAPAIEQWGHDMSRGRGFVLIRGLQTELYSDALSGAIFYLTGLHLGSPMQQNGMGDLIDHVVATSDKTMDDPTARSSRVRDKLVFHSDSSDAVALFCLRPAKQGGASSLVSGAQIYNEIVARRPDLAPLLLEPVHFDWRRQDSNAPSNTYVSPIVSIVDGVCSIYAGSTYILTAQNYPEVPKLTPEQLEVIAMFDAITYEPGMALDMDFQPGDIQWVSNFAALHSRTEFTDHPEWQRRRHLLRLWDERDRDRPRVPNFGKPVVARDQKREDDLAAIPDVGQFSVKTAVIPRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWQ4</accession>
    <name>A0A010ZWQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851071.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2737"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_11"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="22889" checksum="79B835B5A7D0E831" modified="2014-06-11" version="1">MTMVLRAGSAARAVAELRERVTAGHLTPGTQLSEASLTGPLGVSRNTLREAFSTLIEEGLLVRIPHRGVFVATLTAAQIADIYRVRTLLECTALRQAPVDPPRAEGLRAAVDEAERHARANAWQAVGTANMHFHEQIIALAGSPRLNQWMKQLTAELRLAFVTADAETLHRPFVARNAEITAAYEAGEAGPAADLLHDYLLMSERVVLGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXH0</accession>
    <name>A0A010ZXH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+/Co2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3006"/>
    <dbReference type="HOGENOM" id="CLU_007127_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="360" mass="40017" checksum="C3B5B0DF8508B7C9" modified="2014-06-11" version="1">MNEDSAPEPRTAPGDPQTPGTTDHSVSTATPPKCPTRTRLYRDGELVAEGFPAEEISERLASAPDAVIWLDLHAPDESDLGIVVQEFGLHPLAVEDALQAEQRPKLDRYRTHLFANTYAVAFDASTAELTTSEISAFITPNALITVRKSEFDVDALQARWDGNPELASAGVGFLVHGLLDAVVDGHYDATEDVDDCLDALEDRVFEPRDSSDLDIRRRAFELRRAVLQLRRIVAPMREVVERILRNAGEHHLANDFMHPYYEDVHDHVLRAADSTENARDRIASILESEQNIQGQQLNEVTKKLAAWAAIIAVPTAVTGYYGQNVPYPGFEHHSGWIVSTAVIVVLSVGLWFLLRRRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYE7</accession>
    <name>A0A010ZYE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851888.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3341"/>
    <dbReference type="HOGENOM" id="CLU_022256_1_0_11"/>
    <dbReference type="OrthoDB" id="1591714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="425" mass="46648" checksum="3691CE1A74A72FA9" modified="2014-06-11" version="1">MSRTLHLGVFYTGVGPQLLWTDPTHAPHTEIDTFVHVARTLERGLFDAFFLGEGLRVRENRGRVHSLDVAGRPDAITQLAVLAGVTERIGLVATQNATYNYPADLARRLASLDLISGGRAGWNVVTTDNAWTGENFRHGGWLPHERRYERAAQFVDAAKALWSGPDTVERATDLVTLRAAATTPKSPQSRPVIFQAGDSPGGRDLAARHADVVFSAHSTYDEAAAYADDLRARLAAYGRAPDSLRILPGTSVVLGDTPAEATDRAQWIRREQTTGPRAIAFLEQFWGKDLSDYDPDGPLPDIEPTDGELDPSRGTLPIEWRTGKLDRIAQWRVLAEAGGFSIRDLVAEVTPRHEGFVGTPGQVADEWARFVGDGVVDGFNLIPQLIPGTIDEIVDRLVPALQDRGIYRTEYTGTTLREHLDLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ53</accession>
    <name>A0A010ZZ53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852328.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3653"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23503" checksum="1048153273ECE618" modified="2014-06-11" version="1">MIRVYLLDDHEVVRRGLIALLESSGDIEVVGESGSAPEATRRIPALRPDVAVLDARLPDGNGIDVCRDVRSADPSIKALILTSYQDDEALFSAIMAGAAGYVLKQIRGTDLIDGIRRVAAGQSLLDPAVTQQVLERIREGHEHTPSELARLTPQERRILELIARGLTNRQIGEEMFLAEKTVKNYVSSLLSKLGLERRTQAAILATKLLGPHTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZX9</accession>
    <name>A0A010ZZX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570654.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_11"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29670" checksum="F1A5150D8294A284" modified="2014-06-11" version="1">MTTETPVRPVGAPTRVRRRRRPVPDWVLGAAGAVTLLVVWDLAVRTGAVSEDSLPYPAAMLARAGNLLVDREFLTQTGHTLWAWFASLALAGAVAVPLGLLMGYFATLYRPASTVVHAARSIPSTAFLPVAILMFGLGFQMKLALAIYAIFWPILLNAMYGVRDAEPQMLTAGRSMGWNRYRLLTRIVLPSAAPAIATGIRVASSIALIVVLSTELLGATTGIGTVITTYQQAQRPDFVYAGILLTGLLGVVVYYAFTFAERALLPWANAQRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZZ6</accession>
    <name>A0A010ZZZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enolase superfamily enzyme related to L-alanine-DL-glutamate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852725.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_1_11"/>
    <dbReference type="OrthoDB" id="743369at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="139"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="40915" checksum="9E3E5EE7BFECD025" modified="2014-06-11" version="1">MKITSVSPLPVTVELGREPMSFCFLRIETDEGLVGYGEACDSFGASYAGVIGEIVSQVLAPLLIGRDLVAAEPLAEHLRLSTRRRLGDKGVAAQARSAVEIALQDLVAQAVGRSVSAHLGQVRDRVRIYASSTFLDEGPAGFHADLLAPLLERGVRLAKVRIGPEWQQDLRTLTELRGLLPDDVELMIDGSDTFTLATSMPIAARLGELGVRWFEEPIPQANRAAIAALSARSAVPIAYGEHLYGREDFLDALTHDGISVVQPDAATAGGIGESRAIAGLATYYGARVVPHVCAGPIALAANVALAATVPTINLIEYPLFLAPAWEALGAGDQFGIRAIEDGALPVPSGPGLGVRLADDVATRHPYRLPGARIAGTVGGVLDRFVGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAK9</accession>
    <name>A0A011AAK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847459.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_2_1_11"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="32070" checksum="19BFA0D7E13A432A" modified="2014-06-11" version="1">MSSLGTQIAQSLPIFLLIVLGYALAAFAPWAREAGGALSTFVFNVSLPALLFSITSTPSRSTPSWKVVGAYFGGCFVIFAVARLVARFATTLDGIDGSLFAVGGVFSNNVLLGIPLAQAFLGPAALPVVAMVLIFNAAVLWTLATASIEQARGGELTARNLLRTAVTVTVTPLVLAIVVGTVVRLVGLRVPSLVAEPIESLGRAATPLALVVLGIGLQRYGLRTGWKISLGITVVKLVLHPLAVWLLAVALGLSAVETLAVVLMASIATGANVYLMAEKFGTLQGPVASAIVVSTTLSVVTTPLWLALAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABU1</accession>
    <name>A0A011ABU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.523"/>
    <dbReference type="HOGENOM" id="CLU_2823881_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="66" mass="7033" checksum="34214FA3FC8554AD" modified="2014-06-11" version="1">MALSHPTLSTMSTPLVLTLFTALTVAVIAGIMGAAMWGRKHSNEEDLEPANEGTPEHSLFDEVHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC33</accession>
    <name>A0A011AC33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848341.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679507_0_0_11"/>
    <dbReference type="OrthoDB" id="814818at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="433" mass="46385" checksum="7D76C42A3407445A" modified="2014-06-11" version="1">MSQRSSRRKSSHLSLATLPAEPPATHPADALPENLVRLLFQQAADLVEQNDPIQAELWCSDVLGAVWAATDGDPAAEETFVDAWIAAAESPAAGPRAGTAALTVLSMLAGSSPMRRAASAAAERLGVAPPPWASEDVSAGECWHYGDVFGDQETILCAFRRGGTEHAMLVLVDHTLGGIAKDVFFTQAVADSLADLQYELAATPVAFLEPIEPAVARRRLQRAFALTDARVEPRVNDDFAPHRALALARVRQLPPSIETGTLGGAVSPDALIAEFLDAPEAAELPDRDQAEQWARLLIDRALVHADVPARVGPGVLDELLLVDVPDHALLDAAAKNAMPAVLTAWIRWAGHRQELSAAAITWLETALEEILDEFPEAYREPAAVAHRNTCPDTVDLRTSRPAQLHSWPQRTPISSTVLRATSGAGKVGRARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACG7</accession>
    <name>A0A011ACG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.757"/>
    <dbReference type="HOGENOM" id="CLU_039613_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="31234" checksum="5D84A81229BCABE9" modified="2014-06-11" version="1">MMFDPVQLRSFLAVARARSFTRAAADLGVQQSTVSQHIRKLEQATGRPLFLRDTHTVLLTADGEAMLGFARALAEIHDQAAGYFAGSELRGRLRFGVSQDLALTQLPRILRDFRRTHPLVDLELTVELSGTLHARLKSGELDLVFAKRIAGQADGQLVYRERLVWLGVPDLRLDPAGPVPLIIYPPPSLTRERALEVLAEQRRPWRTVCTSASLNGLAAAALGGLGVVPFVQRLAPAGLTEMPPQYRLPALGDVDFVLLHTDRVVPESAEALAAAIRTAGDHPNPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACM7</accession>
    <name>A0A011ACM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinase</fullName>
            <ecNumber evidence="2">2.7.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848546.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.810"/>
    <dbReference type="HOGENOM" id="CLU_033681_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046522">
        <property type="term" value="F:S-methyl-5-thioribose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="42219" checksum="1F53631BFED320D5" modified="2014-06-11" version="1">MVLEPAEIWAYLIGRGSVPATATGTVREVGDGNMNRVFVAVPDDPAIPSVAVKQAPPWIQKLGPSAPMSPERALIEARALRTFAEYAPRQTPAVRDVDETRFAFTMEDLSDLTVLRTALNDGAEIGRTSAEVGELVGRVTFATSVAGADPRVRAALIQESVNPLLAEVTLQYLLGDPFVEAEHNHHHPALEDGVKRLRADPAVRTELAAIRAAFGAKAQALVHGDLHSGSVMVGVRDGEPVVRVIDPEFAMVGPIGLDLGLYVANLVIASVRSRNAAHLASIAECWDAFCAAWREGWPTRVDRLLDDGWLLRELRDVWHDTLGFAAVELVRRVAGYSHASDLETLPDPGPASALVLDLGHKLLVDREICGRRPDPRALAHLVSTSWEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACN1</accession>
    <name>A0A011ACN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848555.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.815"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_11"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="25319" checksum="06598FF0278109F7" modified="2014-06-11" version="1">MTQIALVTGSNKGIGHETARLLGERGYTVLAAARDSSRGTAAADALGATFVQLDVTDDESIRGAAARVAAEHDHLDVLINNAGLIGDHEEARGRPSGTSREALRQVFETNVFGAVAVTNAFLPLLRKAPSPRIVNVSSEVGSITTISDPENPLYQLVGIPYPASKTALNMVTAMYAKELTEVDVFAANPGYCATDLNGHSGFRTPAQGAAVIVALATGEASAPSGRLWGDLSLLGTPGDGVIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADX1</accession>
    <name>A0A011ADX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725060_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="40228" checksum="A6A62C0A4459EC85" modified="2014-06-11" version="1">MPVSPRCCCVDRRRRRWPTTGGDRGGTPRVTGRCLGTAPTRGRTTRAGRATGPDPGERRRSRSRIGAGLLVRRPDSRGSGGVAPLSSPPSAPEPPPSNEPPPSNEPPPSAERPPAPPPSGRPPLARRPSSRRPSSRRPDGRRRSGRRRSGRRPSSRRPDGKRRSGRRRSSRRPLALRPSGKPTRGRKPSRPRPSGRRSGPPGNGPPGNGPRGSGRRVSGPGSGASSGMRLSARPLAGRTWKPNAPRRSGCGLSARLRVGPRPSVRRPLVGWPSNAPPRCAPTRTARPPTPRSASAKPPNAPPPSVRPPSARPPSAPPPNAPRPSAPRPSARPNNAPPNNELPPSALPNNALPHGAHKNNAPPPNTAPPNSAPPNESLNRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEF1</accession>
    <name>A0A011AEF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EDD domain protein, DegV family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849286.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1462"/>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_11"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="28894" checksum="C2EB4F0B84DC2B38" modified="2014-06-11" version="1">MAPHVAVVTDSTSDIPRDLVARYDLTVVPTFVTIGEVTGREGVDISSADVAAALKQGRGPVTTSRATPHSLGEAYRLAFARGYSSVVSIHLSAGLSGTYEAAMLASASAPGPVTVVDSRSIAMGLGAAVLEAAGVAQAGGSSSQVASAAVDAVERSTVLFYVDTLEHLRRGGRISAAAALIGTTLSVKPILRVEDGQIVVAERVRTSARALAKLEALAVTAAGVDGADVVVQHLAAPEQAEALRERLFERVPRLGRVLIGEVGPTVGTHVGPGLVGVAVTRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEK1</accession>
    <name>A0A011AEK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849363.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1514"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="35593" checksum="82C98F6E7959F3B4" modified="2014-06-11" version="1">MKPGKRVTLADVAAHAGVDRSVISRVMNSDPGLNIRPETRVRVLASVKALGYRPNAAARTLRTRRSRTIGLFVPDHADPVYAEIVTGAEAAAAERGCVLVTGSGRVADSAQPYLDLLADGRVDGLLLAGGVTATPAALRESGMPWLLLNRSMADATRHVVLDDEGAAAMAVEHLVNLGHRRIAHLAGPDGSDTASRRASGYRAAMRRHGATPDPGLAVRADYTADGGFQAMTELLGRTPRPTAVFVANVTSAIGAVRAAYRCGVRVPSELSIVAVHDLPFAEYLVPALTTVRMPLQELGRRGVEKLTTTDPDAPVSETVGAPMELVRRESTAPPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF48</accession>
    <name>A0A011AF48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1710"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="43568" checksum="E52702EAFDFA16E2" modified="2014-06-11" version="1">MVGTVPLVTTWPFGDDAGATAPAVVGVGDLRTANAAAVLASIRTAEDPPRVAELARSTRLSRPTVELIVNDLLTSGLVEEEQAPPARGVQSPGRPARRLRFRPRAGYVVGIDVRSRSLAVGLADLDGETVLIRRRTVRRDLTGAARARAVVEAVRAALAEAGVDAHRVCAATVGTPGWVQDTTRLRYVDNLRDWADVDIAAILGDELRCPVAVDNDANLAALGEQWRGGAATTGEMVFILLGERLGAGIITGGRLLRGQHGAAGEIGFMIFPDGSPLAARAIGEPGVGRPGIEPSSIYSDAAIVRGAADGDPDAIRALELVGERLADALAPVLLALDPAVVVLGTSLFALPDLATACEYVLRAAERRAPALLVDPPGWRLSTLGDDAILIGAVRFGLAAVERVLRTRPTELGLSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFH7</accession>
    <name>A0A011AFH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637296_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="9">
        <location>
            <begin position="43"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="255"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="430" mass="44976" checksum="0950CC2F26A391E5" modified="2014-06-11" version="1">MRNDVVQRALREVPLIAALYLAYAGGRVVAARLTGPAFDHAESVWSFERWLHLPSEHSVQQAALHWQALVEFFDSYYAGVHFPATVAALVWLFVWHPERYPWFRRTLAWLTGFALVGHVLYPLAPPRMLAGHGIVDTAHVYGQSVYGPVGTGVANQFAAMPSLHVAWAVLVALAVVRVARGPWRWLAVLHPVTTVAVVIVTGNHYWLDAVVGCALLVLALAITRSRAFTVPVGAVAAAAARTVSVAREHAWPMMRFVVVGGASTLLSVVIFVPLLALMPSAAANTVAAIISTLASNEANRSWVFRSDRGGLLPRVAAAGTVLISYVATTGSLLVLDLTVPHASATLELTVMLAASAVAGLARYVLLGLHIFPSAPAADAAGDPLEAAGAGGSGGAESATRTGGAVLAAHGAGSPARTQSNALSMASSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFP2</accession>
    <name>A0A011AFP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="12" type="ORF">CryarDRAFT_1931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849937.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1894"/>
    <dbReference type="HOGENOM" id="CLU_035168_2_1_11"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23783" checksum="2031250AA406F2F7" modified="2014-06-11" version="1">MTLATAPTDVRLLPGLNEYREVWEEQRRLHALRVADEIPDTVLLLEHYDVYTAGRRTEASERPFDGTPVVDVDRGGKITWHGPGQLVGYPIVQLPRPLDVVAYVRRIEAMLIEVCAEFGLATTRVDGRTGVWIPADDRGPERKIAAIGVRVSRRVAMHGFALNCNSELRGFGNIVPCGIQDAGVTSLSAELGRTVTVADAIALVEPRLPSLAGGPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGK4</accession>
    <name>A0A011AGK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="14" type="ORF">CryarDRAFT_2246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850336.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2210"/>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_11"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG81141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="690" mass="72522" checksum="1995092D5EC8635E" modified="2014-06-11" version="1">MTLIQEPPVQTPPSPPRRVANGLLDPKLLLTSLPDAVKKLDPRVMVRTPVMFVVEIGSVISTVFAIVDPSVFSIVVAVWLWLTVVFANLAEAVAEGRGKAQAETLRRTKTETVARRVTGEEVPATSLVPGDLVVVEAGQLIPGDGDVVEGVASVDESAITGESAPVIRESGGDRSAVTGGTRVLSDRIVVKITAKAGESFIDRMIALVEGASRQKTPNEIALNILLASLTIVFLLAVATLQPFAAYAGAEQPLIILVALVVCLIPTTIGALLSAIGIAGMDRLVQRNVLAMSGRAVEAAGDVNTLLLDKTGTITLGNREATEFIGVGEVAPMEIADAAQLSSLADETPEGRSIVVLAKNEYALREREEGLVASATFVPFTAETRMSGVDLPDRMIRKGAASAVLKWVRDNGGQPGSEVGSTVDAISAEGGTPLVVAEKVGDEPARALGVIRLKDVVKSGMKERFDELRRMGIRTVMITGDNPLTAKAIAEEAGVDDFLAEATPEDKMRLIKTEQEGGKLVAMTGDGTNDAPALAAADVGVAMNSGTSAAKEAGNMVDLDSNPTKLIEIVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFVVAYPSLDTLNIMRLHSPESAIVSAVIFNALVIIALIPLALRGVRYTPSSASSMLRRNLLVYGLGGLIVPFIGIKLIDLVVQFIPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHE4</accession>
    <name>A0A011AHE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570082.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2516"/>
    <dbReference type="HOGENOM" id="CLU_045983_2_0_11"/>
    <dbReference type="OrthoDB" id="1086535at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="32873" checksum="A089398AE10FEBB4" modified="2014-06-11" version="1">METVRNRRVGVEAAGIVLGLALVVGLMLVAFGLPAVNGGPHDVPIGVVAPPAGATAVEQALDRAAPGGFAPRRYGDERALRAAIADRDVYGGLVLGSGGVTVLTASAASPAIAQGLGSLGTALAGRSGSTATTVDVRPLPADDARGAGLAAVGLPLVLGGILPALVLTRRFPGRPWMRVGAALAFALVEGALVASVLTWWFGSVDANFAPVALGLAFGMAAVSLTVLGLEALLGVAGFGLGAATFVLVGNPLSGLASGPEFLPSGWSTLGQLLPPGAGATLLRGNAYFDGAGTATALAVLTGWVTVALLLNAVAAWRTRAEPPAPVPADALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHS4</accession>
    <name>A0A011AHS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2649"/>
    <dbReference type="HOGENOM" id="CLU_069356_18_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="24241" checksum="8B30DF27080E7D10" modified="2014-06-11" version="1">MLDRMSSTPDAPPSSASAARRPQAERSQETRTRILDAAVELLVEEGYARANTLAIQAKAGVSRGRLLHQFPSKEELLVAAAHHVWQKRRSASASGEPLPDDPGARIDVVVEGLWLSFNEPQFWAATELWVAARTEPALADVIRPAERRLGREIWASMDALFGPALTAHPMYQVVRHTLFTSMRGVALTYAFDKRDPSTEPSLANWKQLAKAILLNDVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHW1</accession>
    <name>A0A011AHW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850978.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170431_0_0_11"/>
    <dbReference type="OrthoDB" id="2040341at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="105" mass="11560" checksum="255F1B49C42D49C6" modified="2014-06-11" version="1">MTPDECFDDILDELTPEGVHTATMFGSRALKRETKVFAVVHTEDAVFRLGRGTPAHADALALDGAELFDPSGRGRPMKDWVRVPAEHTDHWLPFAQAALAYLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIG3</accession>
    <name>A0A011AIG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein containing a von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851216.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2858"/>
    <dbReference type="HOGENOM" id="CLU_336464_0_0_11"/>
    <dbReference type="OrthoDB" id="514542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="525"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="727" mass="76123" checksum="B0570D493C13BAC2" modified="2014-06-11" version="1">MTSGDGSGPEKDRLYWRYLVAFGLATCAIGGPAAATDLPDSAFAWVLLGVTAMIGGVAATEAMDAAIRRVQEKVTASRAIAAGPSDPDPDPAPEPGPGSVPDPDPEPVGRPVAKGRTRLPSFVLPALVVLVALLVGISIPQVRDAVYFWMYGCSPPPTLRVLTSAEGLAPVSELARAYERASAAEHDGCPAADLYVYAADTGAAPIDDAREADREYGVVSGGLANGWPSESLGAFGPRPDVWLPDTSVDVARVRALTGGDGTLIPARVPSLGVTPVVLGVPRGVFARSPDRWRQRSWAGVLAEAEKQGVPVLRPGPPRSATGEIATEFVYRSVGPAPDQRADAVQRVERQIGLAFGRGRYTAGDALALLCQRRERTDVASAMIVTEQQLVRYNQGRPLGDNCPLEERDSTGQRLDEAKQLVAVYPTGTGSLDHPFVELRWPDRTTKPAKLIRAWKTWLTSESGRQALIDAGLRPASDGKGAVPVSEPLTGKWGADAAALFERTSPSAQQVLEARTRYDNAKPQARTLVLLDTSGSMGDAVSTASRRNSGQTAEWTRLDAARQALRAAAPQVAPDDEVGVWGFSSTRIPPDRLLPVEKRDPGALGKAMVRLDAVRAQGGTPLYRAIEAGLAGLDGSSGDRTVTLIVITDGEDTDTAPGRPTPDRLRADASAAGIRVSVVAMGDASCAGPALHTLTTATGGECVDAASPTLAPALVGLFDAVRGGRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJG4</accession>
    <name>A0A011AJG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851758.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2435871_0_0_11"/>
    <dbReference type="OrthoDB" id="1791363at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="90" mass="8927" checksum="465FD08179BF8B09" modified="2014-06-11" version="1">MDPASGGGAAFVEFADDGTRTGSDGCNGQGDRWTVTPTSPLATDGPSALIGCDGAPVGGWLAVTAMAGLSSGVLVLLDPTGAEEGRLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJK3</accession>
    <name>A0A011AJK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851811.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124277_2_0_11"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14718" checksum="1E5F6C7DE3AFE2DC" modified="2014-06-11" version="1">MSDSPSAVVRQALDHLLAHDMASFVALYADDAVMEFPFAPPGRPARLEGRSAVESYLDGYTDLVNIQRIHDVDLHQTTDPDVIIGEFAASGLVVATGEPYTARYIAVLTISGGRIQHYRDYWNPLLLSDERATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL86</accession>
    <name>A0A011AL86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852639.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3875"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="24446" checksum="5AB1B92E840202F4" modified="2014-06-11" version="1">MSIRVLLADDQALIRAGFAMIIGTAPDLEVVGEAADGNEALELCHRTRVDVVLMDIRMPHLDGIEATRRIGADPRLAGVRVLVLTTFDDDDNVLRALRAGASGFLGKNVAPGDLVQAIRVVAGGEALLSPRATSGLISRLIRYVEPPVDPLPELALVTAREKEILLLVAHGLSNDEIAGRLHLSTLTVKTHINRTMIKLRARDRAQLVVFAYQHQLVTPGDALPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALC3</accession>
    <name>A0A011ALC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864906.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3901"/>
    <dbReference type="HOGENOM" id="CLU_111152_1_3_11"/>
    <dbReference type="OrthoDB" id="2075110at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="148" mass="15559" checksum="EA3C8B6E0A224F82" modified="2014-06-11" version="1">MLEVLAVLTVVVVGLMVGVELAVSVVLNPILDALPGDSGQAGRAHGGRMLGAAMPVWYITSLALAAAWAVAGWSEQGTGLVLTAAGLLVVSVVMSVLLLVPINNRAKTWTPENRPADWKQQISRWDRLHYVRVAVIVAAFALLATALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALP0</accession>
    <name>A0A011ALP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038556_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458571" evidence="1">
        <location>
            <begin position="25"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="85"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="56167" checksum="F9BDF9FBD39A0A47" modified="2014-06-11" version="1">MTRKHFRASAVVALSAVAAVTLAACGGTTATNDDPANFVSGGTFTIALNEDPGSLSPLTGVSLVQRALVPYAYDSLVALSKDGEAKPWLAESWKATPTSITYTLKDGVTCADGSTFTAGTAANNVKYQANAKNGTFWHGSTITADMTATSSGNTLTITSKSNNPFLLTSTGTIEMVCQAGLDKPDSLKNATNGTGLFKLTSVKGGSEYTYTKRTDYKWGPDDVTSDTKGLPDKVVGKVVTSESTSANLLLSGDLNAVTIAGPDRDRVEAAGKKSQGVPNPLGEMLFNERPNRPTADLRVRQALTLSLDRAAVGELVTNGHYDEMKSLVVQSPQTCVEGGPKWTLPPADAAKAGQLLDAAGYPKGTGGMRAKDGKPLVIRFLYDAGTPSHAAAAEEVQAQWKKIGVDTKLVAEDPNGWSTDLYQTYDWDTGFIQLAPGTPVVLSLFFLGATSEKGGYNFMNVQNEKYNGIARQAMTAADPETACGLWQSAEKELIDRVDVYPLAQTDSPIFFSGATAEVLWGIRPTSIRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALU1</accession>
    <name>A0A011ALU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ca2+/Na+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570703.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4088"/>
    <dbReference type="HOGENOM" id="CLU_827953_0_0_11"/>
    <dbReference type="OrthoDB" id="1529252at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="37793" checksum="29E7E3E13988B618" modified="2014-06-11" version="1">MSILIFVVGAALLVYCAEKLVVYLVGAAHGLRISVFLLAIIFTGIEFDDLALGVALNAEDLGGVALGTVFGTAISMTGIVLALAAIVCPTRVHIPRSYLALFAASPLMMVPFVLSAPLTAADGVVLVLLFVAFIAYIATRELQSSTPIFRNAEILERIGADGPGAGEHGAGGSGAGGVGAGGVGVAGVGGGRPGDRPPFVVTMPFTKDRPLPRWGGIGLAVLALLGLIVAATITSAGIDGILDDYAIGGTLFGATIATLVLSLEDIFLTVEPNRRGAAEIGIGNVIGSVVFGVTAKLGIILLTGGAILVGDDVLAWHLPVLVVMTGLSAYFISTGRLRRWHGFVLLALYLLYWAVSWSMFGEVPIDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGF4</accession>
    <name>A0A010YGF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847874.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458839" evidence="5">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="30103" checksum="F489515546612549" modified="2014-06-11" version="1">MIIRRLLTTTLLCAFAVLMVAPVFWLFVTAILPADDRFSLPPHWIPTSFDFSPFSRVSELVPLGRMAWNSVKVTSLITVGATLTSVLAAYAFARLEFRGREFFFLLFLSGLMIPPQITVIPVFLLMRELQLVDTHASVYLPGMVNALGIFLLRQYFLSIPRDLDEAARIDGAGHLTILRRVILPLGAPAISALAIYLFQMYWNDFFWPNVFLSSPEKLTLPLGLASLQGAQGEGQAAVVFAAITLVVAPLLLIFLVFQRTLVDSIASSGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGY1</accession>
    <name>A0A010YGY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848263.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.558"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="1225778at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="33613" checksum="85A074632073FA1B" modified="2014-06-11" version="1">MADYGIRFAETGGPEVLRYEEIELPPPGPGEVRVRITAIGLNFRDTYERTGLYPVKLPSGLGSEAAGVVTEIGEGVTGLAPGDRVARATGPLGAYATAENVPAGHLVPIPDGVTDEAAAAVLLKGLTVWYLLRRTYPVRSGETVVFHAAAGAVGLIAGQWLRHLGVRAIGTAGSAEKAKVALENGYREVVLYRSEDVAARVRELTDGAGVPVVYDSVGADTFENSLDCLRPRGLMVSFGNSSGPVTGVNLGVLASKGSLFVTRPTLVHYMGELTTAADELFELVASGAIDPNIAQRVPLADAAEAHRALESRSTTGATVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHM7</accession>
    <name>A0A010YHM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848527.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.788"/>
    <dbReference type="HOGENOM" id="CLU_145407_0_0_11"/>
    <dbReference type="OrthoDB" id="1534521at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="113" mass="12554" checksum="37FB3F74734E7B92" modified="2014-06-11" version="1">MAAYALAHLYETSNHPDVFEYIERIQPTMDPFGGRFVVHGTMPEVIEGEWPGTLVIIEFPDLDRARAWYASPAYQEILHLRTDHIPGSAIVVDGVGPDYDAVTTAQKLRAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHT9</accession>
    <name>A0A010YHT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569726.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.875"/>
    <dbReference type="HOGENOM" id="CLU_051661_2_0_11"/>
    <dbReference type="OrthoDB" id="2055578at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="183" mass="19974" checksum="70C9469792E63F9D" modified="2014-06-11" version="1">MHTLITQTVEPTRDVVRTIRDEQLGAPTPCREFDVKALVDHLLQWGPALVGAARKEEVGPVEPPKDWRKALDAHFDELVTGWGAPAAWEGTTRMGGPTEFPAPMIGGMVLAELVVHGWDLARATGQSPRWPEEVLRPLVAEARGMAEQGRQMGIFGPEVPVPADAPSLDRILGLTGRDPAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIX1</accession>
    <name>A0A010YIX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1232"/>
    <dbReference type="HOGENOM" id="CLU_077964_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="23141" checksum="4CBC6D6F6F1228C8" modified="2014-06-11" version="1">MVDRADVLGAIGEPIRFEVLRLLADDGEAAQAALAERLGVTPSRLGNHLAILRAAGLVEPVRIGRSSRYHLPDPDAVRALLSAVDALAGSAPATSTDRLKSAGPSTFARARTCYDHLAGEVGVVLLDRLVAERALIPGPEAESVLTAGDGLDATLARLEVPHPSVGRRKLAVGCLDATAGRPHLGGALGGEILRSFLRRGLLLPGPAPRSLIEHPALERLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJT7</accession>
    <name>A0A010YJT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860180_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="6948" checksum="718623D246CBC0DA" modified="2014-06-11" version="1">MRRRPSTRPQRPADPHALADRTREGGPALLRAVHASDDHEPIADRGVASPPAASPPTYKEINIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK74</accession>
    <name>A0A010YK74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate dehydrogenase/leucine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849607.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1690"/>
    <dbReference type="HOGENOM" id="CLU_025763_0_0_11"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="5">
        <location>
            <begin position="137"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="35382" checksum="F1BA12DEDC9141EE" modified="2014-06-11" version="1">MSFLRDLRDRDFEQLVVCRDPATGLESVIAIHDTTLGPALGGVRMRSYADPEDAVRDAMNLAQAMTYKSAVAGLELGGGKSVINAPADSPRRDDLLAAHARFIASLGGRYIPGADMGTGAADMDLIARYVPRVSSRRDPSRFTARGVLRALDAAASWAGVPVRRVAVQGLGKVGSHLVELLRARGVDVVVADVDASRVRGLDAVGVDEILAADVDVVCPCAAGGVLTEAVIDRLKARVVVPGANNALAADADAAMLAARGIVFVPDFVANAGGVIACEAEVKGTDDAIEAKIDAIGATTESILERASRHGTDPLTEARSLAARRLSTHRPYFPAGDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKR6</accession>
    <name>A0A010YKR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849885.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1863"/>
    <dbReference type="HOGENOM" id="CLU_035712_0_0_11"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="42166" checksum="A736D4BA69F224AC" modified="2014-06-11" version="1">MSPRHVVVEADGGSRGNPGVAGYGAVVLDAGTGALLAERAAGLGVTTNNVAEYSGLIAGLEAARELGAEQVDVRMDSKLVIEQCSGRWQVKQPHLKPLVARATELLRSFPQTTLTWIPRAQNGAADALANAAMDGEIIEANYTGDDVEAAPALDGETAPGTGSVATAPAEASAIGAAPDMRAVATRAASAKAPGWSRGPQRTATTTVLVRHASSVLSPEKRFSGRGDVELSEDGVAQAERVAARLGAREGLDLVVSSPLRRARHTAELIAKAAGLDVIVDEDLVETDFGAWEGLTFAEIHAADPEALSAWLGSDGVAPPGGESFAAVAERVTRARDRLLAEHEGKTLVVVSHVTPLKTLLRFALEAPPIMLYRLQLDVTGVSEVDWYADGPASVRLVNDTHHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL98</accession>
    <name>A0A010YL98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861639.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2069"/>
    <dbReference type="HOGENOM" id="CLU_031468_6_1_11"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="34187" checksum="BC8743342DCFA920" modified="2014-06-11" version="1">MIDRVCVVGAGAVGGVLGTRLAAAGVRVSAVARGATLAALREHGWRLRERSTGALLTAPAAASGDPAELGVQDLVVLSVKATALADAVRALPPLVGPDTVVLTAMNGVPWWFFAAGAGVPAELRGRPLRAVDPDGVVGATVAAERVLGGVVHYSAAVFEPGVAVLNAIGHGLIVGEPDGSRSERAAGVVRLLSDAGIPTVLSTRIQADIWYKLWGNMTMNPVSVLTGATSDRILDDPLVHEFCAGVMREAAEVGDRIGCHIDETVADRMTVTRGLGAMTTSMLQDASSGRPIELDALVGAVREIAAAVGVPTPATDALMGLTRLHARTRGLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLA4</accession>
    <name>A0A010YLA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569994.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2074"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="28396" checksum="3AFA63CC8BECD582" modified="2014-06-11" version="1">MTPPVLRLEGLSRSFGGVFAVRDVSLSVPSGQTRGLIGPNGAGKSTLFNLVAGLLRPDAGVVDLGGDEVTRLPAHRRAASGVAIVFQGARVFPGLTTLENVMVGAHTQVRHGFLAAAIRSRRCRREERDVRSSALAALERVGLTEWADVPATSLPLGQQRRTQLARALCARPRLLLLDEPAAGLRGAERSALAEVIEGLRGEGLTMMLVEHDVGFVSRLADRVTVLDLGAVIAEGTPAEVRRDPAVVAAYLGPEAVDAVAGGEGEPDARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNS8</accession>
    <name>A0A010YNS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851266.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2902"/>
    <dbReference type="HOGENOM" id="CLU_027853_7_2_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="28927" checksum="2C8EAE27FE34DFC2" modified="2014-06-11" version="1">MDIGLGLPISNPARLIDWATRAESAGFSTLALLDRLAYDNPEPLVALAVLAGATTRIRLQTEVLLGPLRSTALLAKQVATLDRMSGGRFVLGIGVGGREDDHAAAGTPIGRRGRLLDAQLTDLRAIWRGEEYRGAPVGPPITAPPILIGAFAPAALRRVAAHGDGFLCAAPLTWAGGLVRTVRDEWSSAGRAGRPRLVCQINVAAAPAVDDARRAIADYYAFTGRDDWAVPLSDPAEIADTVAAYREFGADELVLYCYGEDPGQVDALAGITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNT0</accession>
    <name>A0A010YNT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851273.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2907"/>
    <dbReference type="HOGENOM" id="CLU_030671_2_0_11"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="26942" checksum="6C9D1286E1EB0A28" modified="2014-06-11" version="1">MTVLSALVAALESADVEVVDLTAPLSPSTPVLQLPPPFANTIPLSLEAVSAFDDAGPAWKWNNIHTGEHTGTHLDAPAHWITARDGETVDAIPPSKLIGPVVVVDVRAQVAADPDFLLEPEHVEAWEAEHGRVPDGAWLLLRTGWSARQEDAVAFANADENGPHTPGPSARAARWLASERTIAGFGVETVGIDAGAAGGFEPPFPAHHFLLEAGTYGLTQLRNLEKLPATGAVLVVSPLPIVGGTGSPSRVFALVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNV1</accession>
    <name>A0A010YNV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851303.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2931"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="29250" checksum="878C334F3D49FDE5" modified="2014-06-11" version="1">MRLRDKVVVITGAGSGLGRESALLFAAEGARVVVTDLIEARAEKVAAEVGAAGGQAVPLRADVRIETDMVAAVALATGTWGRLDVLFANAGIGEVGFGTVAFEDLTLENWNAVQATNLTGVFLAAKAAVPVFKAQGGGNVVVTSSASSFAAYPHFISYTASKHGVNGLVKVLSLELGRFGIRVNALCPTHGMSANLALAPDAEVLGRSYEELRAWDKDAAAMPLRLDRPPVLRDNANLALFLASDESQYMSGVCVPATDGGTLARVAIVFPEDVGGEGLGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP10</accession>
    <name>A0A010YP10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase/fructose-1,6-bisphosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851395.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2999"/>
    <dbReference type="HOGENOM" id="CLU_044118_0_2_11"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="26788" checksum="136979B9E2C729D1" modified="2014-06-11" version="1">MSYSDLLPAVVSAAERAGSTLLKYYSPTSRPADRKAMYEVGMQAEAASLAVVKAALDGVAPNVGWYDDDSGEPVPAGEWWIVDGAEGAVNLVHGLAEFGVVIVLIRDGEPQLAVARQPIGDLTYVAVRGGGAFLNGERLRVSSKQDLDAAIVAASQAGNGSETHERFGATWAALADRALLVRNTIPTTFPLLALASGQYDAFFQYEPDLPGAAAGTLLATEAGGVATDLAGEPWRPTSTDVLVAAPGLHRAVREVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP46</accession>
    <name>A0A010YP46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3040"/>
    <dbReference type="HOGENOM" id="CLU_069356_25_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="18179" checksum="E3BEB182CBA0BBF9" modified="2014-06-11" version="1">MLDAVADLLLEAGYDGLTIDAVAARSGVHRTTVYRRWRDTGGLLADALDAAREVPWEPPDTGSLAGDLTEINRQIVAALTEEPSITAALIAASFRSPAAAAALRSFWEDRYAIAAIVVERVAPGVPARPVLLASCAPVFYELVLLRGPAPGDELAERYARLAAASVSRSGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQH3</accession>
    <name>A0A010YQH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852250.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3592"/>
    <dbReference type="HOGENOM" id="CLU_100966_1_0_11"/>
    <dbReference type="OrthoDB" id="1570631at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="24753" checksum="4A4D346D30160816" modified="2014-06-11" version="1">MDFNLQDLSGTFSVGDIAAVLSLAFVLSAAIGWVYRFTHRNISYSQSYVQTLVILGMLIALIMLVVGSNIARAFALVGALSVVRFRNAIKETRDVGFIFLVMGVGMAVGTRFYSLAIISAVAITLIIVVMYRFDWFALNVQRQVVKVQVPPDGDYTEGLQDVLLRYTSEFELVSMETIRGGALTEIMYTVRLKKNSTPGDLIAALSERTAGQRVSVLTGYDQTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQH9</accession>
    <name>A0A010YQH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852252.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3597"/>
    <dbReference type="HOGENOM" id="CLU_040681_1_0_11"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="25461" checksum="D52838DBC6A23DFD" modified="2014-06-11" version="1">MTNRTVRDVMTTEVRTVHPGSSVKAVAEQFDLGRISAVPVVNEERHVLGVISETDLLHKITYQDDADGRPRLLRRHRADRAKADGMTAAELMTTPPVTVGPGASLTEAAGLMERTAVKRLPVIDESGALVGIVSRGDLIRVFTRSDADILREVEREIFLRVLMLPPGMASAEVTDGVVTIRGALARECETEVAGDLVRRVDGVVGVDNQLTYRLDDTTYRAIRDADAPRGVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRE8</accession>
    <name>A0A010YRE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202298_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="54" mass="5685" checksum="69F1448AE664997A" modified="2014-06-11" version="1">MRALLIALGVVAVVLIVLGLVIKAVKWLLIIGAIALVVAIVMGVVEARRGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRF2</accession>
    <name>A0A010YRF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725732.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29979" checksum="820858F9DD0557BA" modified="2014-06-11" version="1">MTATIGGEKSMTSAVLEVAGLGKSYRSRAGDVPAVRSITFDVRPGEFVSVVGPSGCGKTTLMMCIAGLLPLTTGAVTFRGTPLDRPRDGVAVVFQDYSRSLFPWLTVAKNVALPLKDRKVPREQVRSRVAHALEMVGLGHAADLHPWQLSGGMQQRVAIARGLVVEPEVLIMDEPFASVDAQTRTSLEDLLLRIWAETGTTVLFVTHDIDEAVYLSDRVVVLSQGPSVVVADIAIGLERPRDQVATKQTALFGELRGEVYGLVMASEKRTSLAGHTDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRK4</accession>
    <name>A0A010YRK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4004"/>
    <dbReference type="HOGENOM" id="CLU_1472865_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="183" mass="18885" checksum="D87C0807A1E22918" modified="2014-06-11" version="1">MGRQGAAVRTIRELGQLSGVVGRRAALRYAGLGLAAAALGACGVDLPGRHPRAALVTAFVRGTWRVTADGGAGLLTIGDDTWALSGGTPPPGRKHGLLTDARNGTYRIDAGVLTVEVAGEGAPDRGTAIALPAEVSGHEDFSATWSYRGDAFTVPVAWDGTKLVVQIVHPRHGGLILYTAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRP8</accession>
    <name>A0A010YRP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852938.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4066"/>
    <dbReference type="HOGENOM" id="CLU_074949_0_0_11"/>
    <dbReference type="OrthoDB" id="1892914at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="133"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="30500" checksum="5A6A387A17788B6B" modified="2014-06-11" version="1">MWDTERYPLHEPGSASWRDVISTVHAELAAHGCSVLPDFVRPELHETLRAEGASVAPLAHYDVETVNVYNIALDESLPADHPARIPMRRENAFTARDLIPPDALIQRLYTDADFQRFLAACFGKPRIHELADPLAGLCLNVVAPGRGHPWHFDTNEFAVSLLTQAPEGGGVFEYCPEIRTARAENFGDVRAVIEGRGRPPRRLTLRPGDLQLFRGRFAMHRVTTVTGTRPRHTAIFSYTERPGVIGSAARTRQLFGRTLAAHEAGATVRGDQLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRZ4</accession>
    <name>A0A010YRZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853118.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4166"/>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17915" checksum="0B23FDB4C9098028" modified="2014-06-11" version="1">MSDDEEFAGVFGGITRLGNAIRRGRLEERAMQRSGIELDRPALTILITLQTADQPLRIGEIATRMQVVGPHVTRLLPDLEKRGLVQRVVDPDDQRARLIATTDEGTRTVQRYLGTVLGWMRESLADWSAEDRATLLTLLQRFADDFAARVARLDDEDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXI4</accession>
    <name>A0A010YXI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein, CobQ/MinD/ParA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848675.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.934"/>
    <dbReference type="HOGENOM" id="CLU_914287_0_0_11"/>
    <dbReference type="OrthoDB" id="1203604at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="33428" checksum="7856F2F7BCEE7EDC" modified="2014-06-11" version="1">MIVFATSDKGGTGRSVTLSNLAYRQALRGADVCYLDFDFGSPTAGAMFTINEVARGTTDGGTHSYLDGSITDPTRRDVWTTTDRDELRERPRGSGRLVLLPGDSGGGEFSRRQNDVERCARLLRKLNEQFDFCLVDLSAGRSYATELVLRAVGTPELATAESRWLVFHRWTRQHIIAASGLVFGEHGLLANGAGDAEGRLGAAVRFVRTAVVDPDSPQLAGLRPEQVAWLRNCNRELQELAGRHKLGRTNTLGSIPLDPVLQWREQLILDDDVFARQVANRATIDAFEELADRLTDKESWEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXK9</accession>
    <name>A0A010YXK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640937_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="161" mass="17743" checksum="451D6562691170A5" modified="2014-06-11" version="1">MSPEPLRRAHSAEEDARPWDVRVDEGGPVNVVPESVRDAARRAFDARPVDTLVADLMFDSILDHDRRAAADPTVRTMRFGHRSGGADLRVTDQGSGRRISLEVLPAQRASAEVRCAGSTFTITTDDDGRAEFDVPIGLFSLVLRPLRSPQAKPLQTSWVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXQ8</accession>
    <name>A0A010YXQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848751.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1024"/>
    <dbReference type="HOGENOM" id="CLU_069787_0_0_11"/>
    <dbReference type="OrthoDB" id="1745181at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="35088" checksum="200BB3895EBFABA5" modified="2014-06-11" version="1">MDLDAYVAEHAGEWRRLEELLGRRRLTGSESDELIALYQRAATHLSAVQSRAPDPALVGRLSRLVARARSAVTGSSAPSWLTFARFFTVGFPVAVYRAWPWWCGVATAFSAVSFGLIAWFGTHPELAAQLAPESALRQLVEHDFADYYSENPAQDFAAQVWTNNALIAALCVFAGVLIVPLIIVLINNAVGVGEVGGVMVAYGKADVFFGLITPHGLLELTAVFVAAGAGLRIGWSWIAPGPGRTRAQALAETSRAAVLIALGLVVVLAISGVIEAFVTPSGLPTWARIGIGVVAFGGFLTYVFVLGRRAALAGETGDLALGEREDFAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYL5</accession>
    <name>A0A010YYL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">CryarDRAFT_1362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849115.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1337"/>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_11"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="305"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="371" mass="39557" checksum="6AD78FE3B938D763" modified="2014-06-11" version="1">MKPVLVVNSGSSSLKYQLISENRTIKGLIEEIGSDHARLRHDGHEETRAAKDHDDALAWMLEKLEFDELLAVGHRVVHGGTKYTGPTIVDDEVEAGIEELSPLAPLHNPVNLAGIRALRKLLPDVPQVAVFDTAFHATIPAVAATYALPLDLAETHGIRRYGFHGTSCQYVTRRANLDNLIICHLGNGASATAVRDGRSVDTSMGLSPLEGLVMGTRSGDLDPAVPFHLIRAGLDPAAIEDILTKKSGLRGLAGASDMRAVREKAANGDEDAERALDVYAYRIRKYIGAFLAVVPGVQALVFTAGVGENDWRLRAEVCGPLSHLGIELDEDANRAAVGVGEPTSIGTGPIQVLVIPTDEESEIASQAAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0B9</accession>
    <name>A0A010Z0B9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein CryarDRAFT_1993</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1958"/>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="33232" checksum="51B8C904B6464A68" modified="2014-06-11" version="1">MTIGERSPGADDLGNLDGIAAARAEMDLVVVTGLSGAGRSTVARALENVGYYVVDNLPQTLMVTMAELAFASGGAGRRTAMTLDVRSRAFSTDLLGAVADLRTRGFHPRVVFVDASDDVLIRRFESVRRAHPLQGEGRLADGIAAERVLLANARELADVIIDTSLLNGNQLRGRIEELFVTPERTLHVTTLSFGFKYGLPADADLVIDMRWLPNPHWVPELRPFSGKDQAVSDYVMAQPGAVEFLDQYAAVVAMATDGYKREGKRYLTIAVGCTGGKHRSVASALALASRLEARGIPTTVSHRDLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0D4</accession>
    <name>A0A010Z0D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">CryarDRAFT_2008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850041.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1973"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_11"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="28546" checksum="0E5D348AFF94C49B" modified="2014-06-11" version="1">MAKKVTFDRRPLIAGNWKMNLNHLEAISLTQKVAISLTEEQLGLVEVAVIPPFTDLRSVQTLVDGDKLLIVYGAQDLSPYDSGAYTGDISGAMLAKLGCTYVVIGHSERREYHNEDDALVNAKVKAAFKHGLTPILCVGEGLPVREESQHVAHCTTQLDAALAKIPADQVKDIVIAYEPVWAIGTGKVATPDDAQEVCGAIRARLAEKYSPEIANGIRVLYGGSVKAKNVAAIMAKPDVDGALVGGASIDADEFATIARFPEHATAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0G0</accession>
    <name>A0A010Z0G0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569983.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1998"/>
    <dbReference type="HOGENOM" id="CLU_008325_4_1_11"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="4">
        <location>
            <begin position="119"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="42123" checksum="EE2C76FB38850A34" modified="2014-06-11" version="1">MSPGAGDDEEVQWGLPVAPPVDPMLASPVKGIPVGDGLYYEPKFDGFRCLIFREGDRVVLGSRGNKELQRYFPEVVEEVRGSLPERCVVDGELVVVVDDRLDFDALAQRIHPAATRINLLAEQTPAHFIAFDLLALGDESLLEVGYSGRRERLAGLFPADGGPSGPRTHLTPVTTDPGTAQSWFEKFEGAGLDGLIVKAADGPYEPGKRTMKKVKHARTADCVVAGFRWHKSGPIVGSLLLGLYDDEGNLHHVGVSASFTAKRRAELVEELEQYRLSDVSEHPWSAWAEQTAEAPPAGEAVPTRMPGAPSRWTGKKDLSWQPLRPELVVEVAYDHMEGDRFRHTARFERWRPDREPRSCTYAQLDRPVRFDLERVLKGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0Y7</accession>
    <name>A0A010Z0Y7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850282.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692074_0_0_11"/>
    <dbReference type="OrthoDB" id="875398at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="244"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="41998" checksum="5A5D54545AFCF6CD" modified="2014-06-11" version="1">MASGRGAAAQALAAFVVAAVVAAVVTWLVIKPDDDGLPPVPRVESVTELGPLRQHPRVNGRDNGQSAGFGSRSIWVFGDTVTREPWAFISSTGASTTDLLASDGITITSTDVFGTTGPVPTNMIPYTAAEKAFTAKHEKSRCTPEKDTNCGAQIGLWPGAIVADPGRDRVLVFYAKLCRGGPENSRCSGPLGHGLGTGIASLDMTTRKVTRLTAGGASPLPSVETDADPTLFFPYRTAYTAAATLVGDQLYVYGDCNSRCHLARVPIGAVSDRSRWEFFSGRAASGAAEWSKDYDDATTNLSAGSAGNSVIRVPALNAWLNVYLPPLSNTLTAQIGSSPAGPWSRAFALAATDNAGSGTNYAGFAHPEYAEDDGLVQYLSYYQASTYQQRLLRLVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z167</accession>
    <name>A0A010Z167_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6430 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2246"/>
    <dbReference type="HOGENOM" id="CLU_080968_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045535">
        <property type="entry name" value="DUF6430"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20016">
        <property type="entry name" value="DUF6430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6430" evidence="2">
        <location>
            <begin position="86"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29807" checksum="70E2E7692263F9B1" modified="2014-06-11" version="1">MTRLPRLVRGVLGTRRGLQAFAVHTLVAFGLVSAVLQFVGQFTSGPLPQPVGLILASLVVCLLWGWWQALPPRRIVHEFRRPDTSVVIEVGDLLDQECAIVVGFTDTFATRVGPGGIAASSLQGQLLERRYDGDADRLTAELGDALPEAGPSARYPIGTVAVLGGGPFPVYAVAYSRLDGSGIARATLLGLWLSLGRLWESLDRNAERAPVAMPIIGSGLARVDALDQESLLKMILLSFVARSRQGVVSRELRVVIDPRSQHRVDLREVAAFLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1D8</accession>
    <name>A0A010Z1D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850480.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2306"/>
    <dbReference type="HOGENOM" id="CLU_059005_0_0_11"/>
    <dbReference type="OrthoDB" id="554013at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="408" mass="43073" checksum="EF0BDB25E1A2FB9B" modified="2014-06-11" version="1">MTRGLGAGRYADPVLAADAPTSVHELTTVDGAHVTGVLRVPPGARTVVTLMHPRQDVTHHALVPHVLASGRAVWTQGSRSPNNDLNLLHEQAVLDFAAGQVFLRERGFEQIVTLGHSGGATLAAFYCQQAALAPGQRLATAPSGRPVALNDATMPLPDGAVFLAPHPGQGALLQRVIDPSVVDENDPLAVDPSLDPFAVANGFREAPVSAEYEPEFIARYRAAQAARVRRIDAAAAALVAEGRAANRAFKRSGDAGERRRALAPRIVTVHRTDADLRNVDLSIDPNARPYGSLFGRRPDLTNFGLVGFGRMSTAEAWMSTWSTTTTNADFLRCAPGVTVPTLLLEFTGDQASFPSDIAAFATALGASDLTVDAVPGTHFGRELTAGAPSGNELASAVIHQWLAARFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1M1</accession>
    <name>A0A010Z1M1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="10" type="ORF">CryarDRAFT_2424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850598.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2387"/>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_11"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="139"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="536"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="590" mass="64374" checksum="7DA40FA9212AB38F" modified="2014-06-11" version="1">MTTYRTHKAGALRAEHAGQTVTLSGWVARRRDHGGVIFVDLRDASGYVQVVLREEEGHALRSEYCVRITGTVRARPEGNENPDLPTGAIEVVADELTVLSEAAPLPFPIDGQAAGEVGEEARLKYRYLDLRRSQQAAALRLRSQVSAIARRELGEREFVEIETPTLTRSTPEGARDFLVPARLQPGSWYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDIEMSFVTQDDVIEVGEAVVSAIWREVAGYEIPLPLPRLTYADAMTRYGSDKPDVRFGNELVDLTSYFAGTSFRVFQAAHVGAVVMPGGAAQTRKELDGWQEWARARGAKGLAYVLFDAETGETRGPVAKNLSEEHLAGLADAVGAKPGDAVFFGAGERSGTLELLGAARLEIGRRCGLIDESRWEFLWVVDAPMFEPVGGGEIGVEGAQGAWTAVHHPFTSPNADWIGRFDEAPGEALAWAYDIVLNGNEIGGGSIRIHDRSVQERVFQVLGLTEEDQQGKFGFLLEAFKYGAPPHGGIALGWDRLCALLAGVDSIRDVIAFPKLGSGGDPLTGAPAPISPRQRKEAGVDGKPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2P5</accession>
    <name>A0A010Z2P5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851119.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2774"/>
    <dbReference type="HOGENOM" id="CLU_063440_10_0_11"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="11174" checksum="73360E6FC6A06B9A" modified="2014-06-11" version="1">MRITVSTAQVLAALLAEPDADHYGLELMRAAGLASGTLYPILRRLTEARWLTADWEAIDPVAAGRPARRYYRLTAEGAVEARRALAELRARTSPPDLRTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2S1</accession>
    <name>A0A010Z2S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851145.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2799"/>
    <dbReference type="HOGENOM" id="CLU_075562_0_0_11"/>
    <dbReference type="OrthoDB" id="1024950at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="315" mass="33977" checksum="91172D65F4C64A8B" modified="2014-06-11" version="1">MNILLWHVHGSWTTAFVHGPHRYLLPVTPDRGPDGLGRARTWDWPASAVEVTPAELREADVDVVILQRPHEAALAREWLGRDVPAVYLEHNTPGTDGAGTGGVPGTRHPMADAGPPIVHVTHFNRLFWDSGASRTAVIEHGVPDPGHRWTGTVERAAVVVNDPVRRGRWTGTDLLPALAGPVPLDVFGMRADRLDVPGVRTFDLPQSALHDAMAARRCYLHPIRWTSLGLSLLEAMHLGMPVVALATTEVVRAVPPGAGVISTDPADLAAAARRYLDDPDLAAAHGAAARRAALERYGLTRFLDDWDALLGEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2Y7</accession>
    <name>A0A010Z2Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fucose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570184.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_1_1_11"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="481" mass="47108" checksum="01BA5413EDAEE0D7" modified="2014-06-11" version="1">MPERDRTPSPRRHYAAVATLFALDGAIFGTWAARVPDVADRVGATHTALGTALFGVSLGALVSMRLTGAWCARFGAGRVAAVAGVLVALALIPPGFCTGLGALCVALTAFGAATGAANVAANSLGVSLGQHRRRPVMSALHALFSFGGLAGALLGGLASAMLPVPVHFTAVATVGALLATALRPALRSPDSNPTPDVTPAAAPEGTPRAAPAGTGPAPVGAGPGGSGGRGVLVLLVLLGAIAGSTAFAEGALSDWGALHLRETLHATPGVAAAGYAAFCLAMGCGRLAGARWVIRFGDTRVLVAGALAAAIGATAAAYGTDQFVALGGFVLVGLGLANVFPLVIGRAGLVGGPRGVGLASTVGYSGLLGGPPVVGFLAAHAGLPAALSTITALALVAAALAVVVAVELPDATTVAAALRSRARVYAALTADRLGASVGDLSLLLDASDHAVTTDHTRSRPATAPPPAGTIRGYPGLEFLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z357</accession>
    <name>A0A010Z357_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851299.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2929"/>
    <dbReference type="HOGENOM" id="CLU_042670_1_0_11"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458930" description="Endo/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="411" mass="45123" checksum="0912E3B1968E9253" modified="2014-06-11" version="1">MKRVLTVAAVCAAIIGTSPAGAVAHDERAVRFATYNLSLNRPTEGLLREHLADPGVDDVYRRQAHNVAEVIQRTHPDVVLINEFDYDPEAARLFAENFLAVPQNGAPAQRYPYRFVAPSNTGISSGFDLNNDGVTGTTPGEAAYGDDSWGFGQFPGQYGMVVYSKFPIDSRAVRTFQRFKWKDMPGNAIPTDFYSPEEQAALRLSSKSHWDVPIAVGRKTVHFLVSHPTPPTFDGPEDRNGRRNHDEIRFWADYVTPARASYVYDDKGRRGGLHPGQTFVIAGDQNADPDDGDSYRNAARQLTGHPLIDARSFPSSAGAVEAARLQGGANTTQKGDPRFDTADFADTAPGNLHADYVLPRVGTPILRSGVFWPVRSDPLSRLTGVFDPQWSAVNGFPTSDHRLVWADLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z377</accession>
    <name>A0A010Z377_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851327.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2949"/>
    <dbReference type="HOGENOM" id="CLU_045518_2_1_11"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27080" checksum="8B7D066ABD5EB3F5" modified="2014-06-11" version="1">MTLLVIGGSGFLGREVARQAGRSVTTHFRAGGPGRRLDVRDRAAVLRLVEELRPDVVVNTAYVQADWVTTAEGAMHVAAAAAATGARLVHVSTDLVFSGRDVTYDETSVPDPVTPYGAAKAAAETAIKGLVADAVVARTSLILGDGDSGHEKFVHALAAGTASGGLYTDTVRCPVHVTDLAAALLELAGSTYAGIAHVAGADALSRHELGMLIARRDGLDEAALPTARQGSGPLDVRLDGTRTQARLRTRLRGAREFLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z471</accession>
    <name>A0A010Z471_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3289"/>
    <dbReference type="HOGENOM" id="CLU_1052731_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="120"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28412" checksum="A7E2B9D7AF3444F1" modified="2014-06-11" version="1">MIPQHPAHGSIGYLQLPTQDLARSAEFYQAVFGWRADLEFGSFEAPGVIGQWTTGREAATGGGPLLWITVDRLSPALTAVTEHGGSVRTRPVLDHRKRWLAEVEDPAGNHLGVVATARTATAQTLLAVRDVEASSRWYQDILGLVSDHGGPSYERLTADGELVLQLHHVDVDHDHGSVIADPAGPVGNGVLVWLGEVADFDGVLARVTEYQATVVRAPHRNPPAGGGNGPAHREIWLRDPDGYSVVVASADGEAWQLGEERADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4T3</accession>
    <name>A0A010Z4T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570470.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3491"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="31948" checksum="99AD2E6540BF2FAF" modified="2014-06-11" version="1">MDAIQIAGLTRRFRRVDALRGVDLTVPGGMFGLLGSNGAGKTTLMRTLAGVLRPTSGTVIVNGHDLTSRDGRLAVQRRLGYLPQDVGVYPDLTAAQFLDYVALLKGLDDSTARRRQIEALLDTVGLSDVAGRRLKGFSGGMRRRVGIAQALLGDPTLIIVDEPTAGLDPEERIRFRTLLSTIATGRTVLLSTHIVEDVAQTCGTTAVMAAGRVIYTGPVSDVVAAGNDRTWEISRPGSAGPLPPGAGTVVSAVAVGAAVTYRVIAEGQPAADATPVAPTLEDGYVALMHRARTAEAGSGVGSGQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z599</accession>
    <name>A0A010Z599_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852391.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3679"/>
    <dbReference type="HOGENOM" id="CLU_031365_0_0_11"/>
    <dbReference type="OrthoDB" id="1425262at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="362" mass="38334" checksum="FF3A7BE1A42BEA11" modified="2014-06-11" version="1">MSKLKPWLSLGGIGVFAVLLLAVAPLVLTEHWLNNLGKYCCWAIAAVGIGLAWGRGGMLVMGQGVFFALGAYSMAMHLTLETAGDRVPGFMVLYDPLAPLPVFWEPFRSAGFTLLAIVLLPVVLAGLLGYALFKRGVKGAYFAILTQALAVALATLISSTIRETGGDTGLSDFKYFFGFVLNDPANKVMVYLIAAALLILCLLVVWQLYRSRFGELLVATRDAEERVRFLGYDPGTVKLVAFVVSALMASIGGAMFVPIVGIITPAEIGAAASIFLIAGVALGGRASLFGPALGAMAVGWGQSSLGSTWPDGWTYLLGLLFIVVILFLPKGLSSLPARFTAARRSPAEPQAPTAAELEEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKR5</accession>
    <name>A0A010ZKR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kinesin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.252"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TIR" evidence="9">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="970" mass="106382" checksum="DF42A2F43EA1B993" modified="2014-06-11" version="1">MGGVNAVGGASHQSSVFVSYTAADRKWAEWIAWAIEADEALETRAYLQDWDSVPGTAWVEWVDQVVRECDQLVAVCSPSYPGSSAVGTAEWQAVWARDPSGSDRRVVPVVVQPCDLKGLLAGRSWINLAGLDVEEARTQLVDGLRAARDGRAKPHSEPAYPGTGAATGRSIGVEQPDFPGALPGVFNVRRANPRFTGREGLLDRLHKELSTVGRVTVAAVRGLGGVGKTETAVEYCHRQSSAFDVVWWIDAEDPTAIPGQLAELGAALGLPEATAGDPLNTAAAVKATLGRRDRWLLVFDNAEDPYLIENWVPSSGTGQVLVTTRRSGFRSLGTVLEIAVWDRAESITFLVDRCPHTDMGSADRLAHELGDLPLGLEQAAAYMDTEDIGADRYLTLWESASTRLLGKGRVRGHAHTVATVWQLSVERIASVNPAALQLFRTCSLLAAQPIPLELFTAADAEWAGALSEIVQNPVEFNDAVGALASYSLVAREIDTVRLHRLVAATTREKLDSADLRRVHDDLLQVLRRIAPQQVRSNPNVWHWWRLFLPHVLAAVMPVLAEENPDRDSGPVMNSRVGAGFHLGNLAGAYLFAVGQSAESIWVSQQILTSSEKKLGNSDRITLGARNNLASAYQAAGRVADAIQLLEQVSTETVQLLGADDPGTLTARNNLAAAYQSAGWIADSVRLLEQVLESRRRVLGDLHPETLRTSNNLAHAYMEANQPRKTIAILEPILSMARNALPRDHPDILIYRDNLAAAYLAIKRPAESIEMFQEVLEDKIRVLGREHPDTFNTRNNLAHAYKAAGLFPEAAEMFRLLLADQLRVLGDEHPQTLMARNNLAGVYQDEGKWNDAVVLLEQVVDEQSRLLGEHHPHTLVFQSNLGGAYQRARRFDDAIRTFEYVLSARQGLLGERHPKVFQARRNLAVAYQAAGRVDVATTLFQQILFDCERNFGILHPLTRRVREDLAGVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL13</accession>
    <name>A0A010ZL13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.342"/>
    <dbReference type="HOGENOM" id="CLU_068637_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="30929" checksum="9B3047031B488904" modified="2014-06-11" version="1">MANRGRKNKATGPQPGTHQLTDVTAEIVRDLDTEAGWMLLLDGVPNSYLDLDDPTHLEFEYQQWMGRAVDVHAPEADVLSFVHIGGGACAFPRYVAATRPGARQLVAEYNPELIALIREVFGIRTGPGLRIRAGDGRDVLAGQHSASADVVVRDAFVGPVVPPHLTTTEFMTDVARVLRPTGLYLANVTDGPPLALARAEVATARRTFEHVALVSETPVLKGRRYGNLVLMASPSPLPTGDLARLLARSVAPTRVLEGPDLEKFTAGAVVTTDESPLVPPAPPPHLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL72</accession>
    <name>A0A010ZL72_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">CryarDRAFT_0439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848021.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.423"/>
    <dbReference type="HOGENOM" id="CLU_061281_1_1_11"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="23881" checksum="74F5F28613475672" modified="2014-06-11" version="1">MDIQQDTVALVPAAGRGERLGPGAPKSLRHLGGEPLVVHAVRRLAAANSVAAVVVAAPPGAAETVRELLAPVVLTAELVVVEGGGTRQASVAAALAAAPAHCDVVLVHDAARALAPPELADAVAAAVRAGHPAVVPVLPVVDTVRQLGEDGGASSTIDRERLRLVQTPQGFARSVLAEAHASCEDSLTDDAGLVERLGLPVHTVPGHASALKVTRPFDLVIADAVLAAERSVAGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLX4</accession>
    <name>A0A010ZLX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavoprotein involved in K+ transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.688"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="493" mass="54960" checksum="DA9F4B3C63CCD77D" modified="2014-06-11" version="1">MPEESVRVLVVGAGFGGLSAAAHLRAAGYRSPDDLLIIEKADQVGGTWRDNTYPECACDVQSVLYSFSFAPNPDWPRSYSRQPEILDYLVRTVRDTGLIDHVRFGCELFGAHWDGTHWIAETSSGTIRAQVLVAATGALSAPRLPDLPGLVSFRGDAFHSARWDHSVPLKGKRVGVVGTGASAVQFVPAIAPEAGRLTVFQRTPGWVVPRGDRPYLKAERALYRRWPITQRIARGSTYLYRESYVLSMAHFPKLLPGMQFVAETHLRRQVKDPELRAKLRPPFQIGCKRALLSDDWFPALQRPNVELVTAAAAEVTPTGVVDAAGREHDLDVLIFGTGFTPTEPPVARLITGRAGLTLAETWDGSPRAHLGMTIHGFPNLFLMYGPNTNLGHSSIIYMLESQARYIVDAVRTLDRADLASLEVRAETEHDYVADVHRKLERSVWNQGGCASWYLDRNGRNSVMWHTFTWRYRQATRRIDLDNYHLKAVPLNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMB1</accession>
    <name>A0A010ZMB1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="1">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="1">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnB</name>
        <name evidence="3" type="ORF">CryarDRAFT_0824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848552.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.813"/>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_11"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01677">
        <property type="entry name" value="Salvage_MtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="PTHR10640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="22690" checksum="4240037836114571" modified="2014-06-11" version="1">MTGPDYRTDFRGVLEGAGTALAAESARFAGIGWMRGTSGNLSIVLNRDPLRLAVTVSGLDKGELTSADVVVVDELGRAVAEQPRPDLIPSAEAELHARVAQLSGAGAVVHVHALQAVLAGHWWPGGIELRDLEMLKGIGRLAHDETVTIPVVPNSQDMKVLGDDVAKVFDPAVPAVVVARHGMYAWGRDLLQARHHTEIVEFLLQFTVETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMD9</accession>
    <name>A0A010ZMD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine betaine/L-proline transport ATP binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848605.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.854"/>
    <dbReference type="HOGENOM" id="CLU_000604_2_2_11"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="49"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="39117" checksum="4BEFF24A4D49EE3F" modified="2014-06-11" version="1">MTATTARSGTPERADDLPSADVDISVRNLWKVFGPKADRVPTDPELAALPRTELKEKTGCLAAVCDLSFDVEPGQVFVVMGLSGSGKSTLVRCLTRLIEPTAGEVLIQGRNIREADEKALRELRRHQVSMVFQHFGLLPHRRVIDNVAYGLEIRGEKKTDRLARAHEVIELVGLKGFENSLPRQLSGGMQQRVGLARALAGDPGVLLFDEPFSALDPLIRRDMQNEVIRLHREVGKTMVFITHDLSEALKLGDRILIMRDGRQVQVGTGAELVGAPADDYVRDFVQEVPKANVLTLRWIMRPPAADEVLDGPELDPDVLVKDAVRAVLEATAPVRVVESGELLGVVGDAEVLGVVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNL4</accession>
    <name>A0A010ZNL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_1320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849067.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1300"/>
    <dbReference type="HOGENOM" id="CLU_304782_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="10">
        <location>
            <begin position="147"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="466"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="550"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="603"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="681"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="751"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="974" mass="103471" checksum="2A40A8D103C52B65" modified="2014-06-11" version="1">MREGRAGIVRWGAAVITTATVIAVAAVASLFAAHVSDRTRDREAKAQTVAAATRLERQVDHYVEALRGVAAWLRTEGWPSRAEYQRYADALAVRPRYPGIQVVGAAQFVDGSARAVFSRRTATDLAAARQGYPAFRIRPSGTGVALPITYVDPVGGNEAAVGFDLLSEPRRRSAALAARDLGVPRLTAPTKLVQETGRQHGALVMVPVYRTTTTPATAAARREAFTGVVYAAFRMGDLAEGALGADADRLQLDDIGATAAPATSPDALYAPAAAAGGTPERAELSMQGRRWLVRFAAAPNLGPLTQYGPLALAIGGAAVAVLAGALLLALTSARTRARVLAVSMTAELHSVTDTATDAIVTVDHTGSVTAWNRGAARLFGVEPAGILGAPVDRVIPGGLPALTDGPEAASPHPDPTIELDATSADGSELHLEASVSTWKSPRGLFATAILRDVTERRRAEAEIRRTNDLLEGVLRGATECAIIGCDATGQITVFNEGAHRMLGYRAEEVIGTSVLDALHDPAEMAAVAHELGVESAADIFPVLLRDGLPSTREWTFVRSDGYKLPVLLTVTSLRNVDGTVEGHIGIAFDLTEAHRLERERARLANRFEQLVDCSGEGIYGLDQDDRITFVNRQAARSLGWDVEELLGRVAHEVLHHHLPDGSPYPAEDCPIARTIAGGSTNRVDSEVFWRRDGTPLAVEYVAAPLRRDGQIEGAVVTFADITDRKRTEQALKDAVAGLREIDQVRTDLVSTVSHELRTPLTSISGYLELLLDGDVGPITPAQAQMVQVAHRSSQRLLLLVEDLLTLSRIDAGVFRVRQDEVDLTPLLDAAVGAIRPLALSKNITLTCDVPADVGVVRGDAAHLDRALLNLLSNAVKFTPGGGAVTLAGRRVGDEVVITVADTGIGIPADEQSRLFDRFFRSSNAMDEAIQGTGLGLSIVRTIVEHHGGRIGAESELGTGTTFTLTLPVHAAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPA8</accession>
    <name>A0A010ZPA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849454.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1571"/>
    <dbReference type="HOGENOM" id="CLU_035309_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="37855" checksum="956FBD90E184693D" modified="2014-06-11" version="1">MRPPTLMVSAAYAAQGVGYAVVVTALPAAKDRMGFSDAVVSAVLLGVCVAAALGSGLADAVAVRRGSRVALCVGFGVQFVALLGISLAHQLPVYLVAVALYGLGLGTVDAGSNMQGTALQARAGVPLLGRLYSVFTVGSVLGALLSAGVAALGVSALTLVGVVAFVQLGLASAGRTRFLPTLPACTADRAPATPLPRAGIWAVGSLVLVAYVLDAAVSTWSTIYLADGLRASAVLAPVAYAAYQAMVLLTRLVTDPAVVRWGRSAVAVSALLFGAAGCALIVLGPAAPVAVAGFAVAGLAVGAVVPIAFAAAGRLLPARSDEVIARVNVFNYAGAVTGAVIPGLLGTGAALRFGFVAPALALLLVLPVARRLTSSVPQGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPQ4</accession>
    <name>A0A010ZPQ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.212"/>
    <dbReference type="HOGENOM" id="CLU_002554_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="581"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="985"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1167"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1313" mass="139521" checksum="52ADCEA33FF71111" modified="2014-06-11" version="1">MPTSLKGLRPAATSEGPVRRVPNAGTPSEDRSNSGPEQPVNRPLTRSQRFLGNAPIRVKVVLITLVPLMAMFLFAGILTYIVTDEAQSAQQVQQLARLGSQASTLVNDLQLERSAAAYYVANPGEGKTHPPLRRFIEAGTTTDATLRQFLAEAGRLDADTKAPIQSELQSVTRGSTTLVNGRNNLLNQARNGGVTVNLAAQKYETLIGDLLKIGDRLAGAADDRDLSDQLAAVSVFSRYKESIGREQVLVLDVLVDQDKKFTNESFKEVTQAATEQETFNTEFGETATPTQRGARNDTVSQEGPYRSAASRIRKTSIGAEINTTQTQWVADSTQIDSVLRNVEEKLSADAVQAAANFRDDAIRKTIIVITVALAALVIALLVSLAVARSMVRPLVRLRSSALEVAYQSLPEVVRRLQDADQQTAAQASAETRARTLDIRSGDEIGQVAQAFNAVHLEAVRVASEQAQLRQSVSTMFVNLSRRSQLLVDRLIRLIDGLEQGERDPDRLSELFKLDHLATRMRRNDENLLVLAGADAGRRWTRPAPLVDVLRAATAEVEQYTRVKLGSIDDSVEISAAAVNDLVHLVAEILENATSFSSPRTDVVVDSRRVGDHVIIEIEDQGIGMSREQLAEFNERLAKPPVFDIAVSRMMGLFVVGRLASRHGVKVMLRDASGGGVLAIVTLPSGVLHGDQPVVPAPLPAAESDEHGDRPVERVTSERVDRTGEQPALPAANAHYAPTGNFGAPTPGQPPFGGAPQLPPTPFGGNQPSFGQPGQHQQPQHQQPEQPFAPAAEQNASDPWAQRSAPPFGGVRQDAEEQDNQREQYGPPSHGQPSARDLFGPVTPEPLPRRDERDDSGAQGFPFAPTTPTPAQPPFTAPGAVEEQPDPSWSEPTRPVPIIRDPAAAAATGTHSILGDLRPETAPNEAREPDLTWSTGGIPRPVADEQSSPNAATTQPGFPAPSPKPAGPTPGGPTPLPVRDPFASREAQVPQQQTRPIAPTGPLAPTSPAAPPAPAAQAAQAPAQKAPEAAPTSPSRAGGGSAADAMAALRREASSDRSNATGAQKIFRAGPSDPPNSDPTIEMPLPIFDAIESEWFRSRTTAAPRNGSSNNGSSWSPPRVPEAPGAARSTAPEEPEEKQAPETTRLPEAPVSPVVGGEVPFAQNATAAWSRPRPNGSNGSNGTNGSNADEPATPSGMERQEEPVSVGAARQPATAAWESPADAGWRAAQAVAEAAPSSTTKTGLPKRVPMAHFVPGRVETAAKKASRPTSHRSPEAVRGVLSSYRSGLEQGRQAGRPSPTGTTLAGSPETQEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPS7</accession>
    <name>A0A010ZPS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1734"/>
    <dbReference type="HOGENOM" id="CLU_063749_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="162" mass="17700" checksum="52C47316AE45E707" modified="2014-06-11" version="1">MIMADTHVPKRARDLPSALWAAVDDADLVIHAGDWVDARLLDTLGERSARLVGVYGNNDGPALRARLPEVARLTLDGLRLAVVHETGAAAGRERRCAAAYPDTDVLVFGHSHIPWDTTAPNGLRLLNPGSPTDRRRQPYATFLTARVEDGVLTAIDLHRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPT2</accession>
    <name>A0A010ZPT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849700.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1739"/>
    <dbReference type="HOGENOM" id="CLU_1007289_0_0_11"/>
    <dbReference type="OrthoDB" id="2153801at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="31394" checksum="5304ADA55900807D" modified="2014-06-11" version="1">MGEDPVLAVWYFYEPDEVRTFARDGDRITFGRDDECDLIIFSAINGESLSRVAGTIWRMEGELWVRNLSDKHELWITQPGMPPLPPLPPRDPARRDPGAAQSVPGELAYVHGPDGCVLVVAQQRAEPALPAVRDDRPTTTMPPVPPELRPVAAALCEPLIRGRRLPASYEEVHRRLPGRTRNQIRDHVRRLCELYLTELPELRDRVAARKQLEERELGLPAAPTTVHKGIRVFAPVPGPDDEAQRRRELTLPDYYEVAHLLVRRRTVTTEDLRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQE0</accession>
    <name>A0A010ZQE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate/guanylate cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569978.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1953"/>
    <dbReference type="HOGENOM" id="CLU_004435_3_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1192" mass="127346" checksum="B20E229011F3BBB8" modified="2014-06-11" version="1">MGRPGDRFCGRCGSALLRKCPSCTAGVELTAETCPHCAADLDPAARGLPVPGVASREERRVVTILFVDLTGFTNLGERLDPEDLRALQQRYFDTVARAIRRRAGVVEKYIGDAVMAVFGAPVTQEDDAVRAVRVGLELQADLDGRIIGPSGPLRARVGIATGEVVVDLDAIRDGGQALVAGDVVNLASRLQSHAPVGGIVVSSATWRASREYVEYTEMPPVMVKGKAGPVPVWRPLRLVQRRWDRHRDHGPFVGRGPYLDHLAGLLRATVDDRAPRLVTVVGPAGVGKSRLVRELNRHAEQAMPVGVRWVGGRCLAGGEGGPFAAVAEVVTAYAGVLESDSADTARRKVVDSLHGLLTTAERSSVVDALAPLVGYAAPPVEADEAQAAWRMFFARLAARRPLVIVIEDLALAEPPLLDFLRQLVDTVDGPLLVLGTARPELLASRHVPWYDATHPRHALVELPPLDAHDTLTLFRALSVDSPIPEEALEHLTVLAAGTPLYAHEYVRMLADQQSDDAEGALPLPDSVLSVVASRVDLLGPRSQRALQAAAVIGEVFWPGAVATVAELARDEVEALLAELRAKAFIRPATGHVLAGEPALAFSHAVVRDMAYRRQPRALRVVRHQRAARWLQSHVTGRTTEAVDAVAHHRVAALELARTLHMDVRPFLPPARTALVAAAERAASLHAAPTAVDLLDKALALWDDQNTLTLEELAALEHPAARDDEVSRLSALVLRWRLRFTASPDEFHGAADVARCASQLEVLGARDAAASARTLLSQVAWARGDRTAALAHLDRALAPYGAGDESPVRAAAHAELARLRMMSYEVDEATTAAKTAGDLARRLGLPELEVNAQITEGAARYLAGDLSGLTLLERAVDRSRTDHLRSLRRASENLASALQEEGEIARSFALLDEAAATTLNFRGAPHPGHTPMRAYFDGDWDATLASADAAFTGDEALDAEWSHLRTLAAWLRALRGEDTGFNPEAIVVTAARHGSRLAMANALAHAALYRAVNGSAEQATVALRRLEAEHSAEALAPREWLAAAAHAAVLTGVRCGLQGEESAGWLKGVLDGAPRETLWVRAARSVVNGAQAARNGDHGTAALHHAVAASVYERMGDATDAALATAWSLRAARAGEVAPVPELTTRLTTFGLRNRARLLLRFATTDPLDTTDVPDDPGPLAGQDSSSSPASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQH9</accession>
    <name>A0A010ZQH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, cyclopropane fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850064.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1994"/>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_11"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="448" mass="49264" checksum="5D1A8484B2FD25FA" modified="2014-06-11" version="1">MTYLASEHATVADRLHPVINMIFGAEPPVRIRAWDGSSLGPSESEGGPTLVIRNRRALRRLVWSPNEVGMARAFVSGDLTVEGDFIGALDRMLHLFDATQGLHLSSADKRLLVASAMRLGAIGSNPPPPPEEMRPTTGMLHSVRRDAAAIGHHYNVGNDFYRLVLGESMTYSCAYWPDLDAANPATTLEQAQTGKVELIARKLGLKPGMRMLDVGCGWGTMAIHAAREYGVHVVGVTNSHEQAVGAAKRAAAAGVADLVEIREQDYRDIDDGPYDAISSIGMAEHVGTDQWRGYAELLYGLLKPGGRLLSHQITQPPTVTDTLQSRRQGKPERTFITAYVFPDGELQSVGWISDQLETVGFEVRDVESLREHYARTLRAWVSNLEQNWSEAVRLTSVGRARVWRLYMAGSALAFDRNRIAIHQVLAVRPDRKGHSHMPATRASYATVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQQ2</accession>
    <name>A0A010ZQQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848276.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150710_1_1_11"/>
    <dbReference type="OrthoDB" id="2010577at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="105" mass="11360" checksum="C54F89122B22E233" modified="2014-06-11" version="1">MARRPTRPTPEPLDVDAVSVVTAGTVLWGVGALVLATFGRGWLSDHDDEWWIWTCVAGFVLGLVGIAFVRRRRSKLGRVAAARAEQPVAPAVPAETEPAQRTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRQ0</accession>
    <name>A0A010ZRQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848673.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.933"/>
    <dbReference type="HOGENOM" id="CLU_031194_0_0_11"/>
    <dbReference type="OrthoDB" id="372967at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="610" mass="68457" checksum="C40793765D9CF1A1" modified="2014-06-11" version="1">MRMQPRQQMLDIWRAVARLGADWEWGGRDGRNSISDAEQLLCLMHPASLVDGFQLDRPDDTHPDALAALRDMGDSIEIPRKLIRVLIDYMRTYTDENGAPDFSGGSYFRTEDPDDKVTDEQSKMHVVDSYSMSITLTLATLGFARVFRSRVTRTDLRSQVDELEKLASIRLSAAMVGLLRSFTVNAFGEGTLPWRTLINTVRRRGQSDDRVVSDLQERLQEVRAGLRDLSIGSGQVELENSNLLFECGWTWGTLRGAPTIETTEPVGVQGSGLAERRPLLYFTTIALAGIVDLTKERTRVLRLLNEEQQRLAAALQLRYDLTRSYWATVASSEASSDGGDRWPLEELPWRTSDGEESDYFSLLVTSLVTHDLSKRNAPDSDLRRVLSVLEELSSRGRVTRRALTNDVALQLHTPGVPLRLGGSEGEVNPRLTWVVSDFSVMLLKRVVTLALRARSPELRSQLTTLADQVWDHLNSRRMDDGGAGALWDQPAAIFQVGREFDLPSWYHTERVMECLVMLADLVLAPPARSQRLYDIARDRIAEAEQLFDREIFAGSLEAGPSIRGSMQELRAHLRRAQRVLTEKPGTADALASEVLRRLDQLAAAQQSAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSH7</accession>
    <name>A0A010ZSH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NHL repeat-containing protein,protein kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848978.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1224"/>
    <dbReference type="HOGENOM" id="CLU_383001_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="740" mass="77320" checksum="38FD17D4C7217EE2" modified="2014-06-11" version="1">MLMNRARLDAALPAFELGDRIGRGGYGVVYAARHRRIGWQAAVKVLADGDTDGPLRERFVSEATSLAELDHPHIVRIHDYVEHEGLCLLVMERLNGPMLHQRPGLTGVEACGAGLAIADALAAVHARGILHRDVRPENLLYSSDGTLKLVGFGTVSDGASLISAASGTPAYTAPERIQGFRLGPATDVYSLGVVLYELFSGRLPFGRDLPLSALLHHHVNVPAPWLSDVPRPLAAVLDRALSKSANDRPRSGHEFAVELGSAAAGALGADWLDQVAVPIRVSGRVRDAARGRLADADVRPAVTARAGVALPAGGSAPTSGAPVGGGGGVVTAPPDPAGSFGETESEVTRRARQAFGATGRHSTITEPEHPNDAPPADVPPPADFSDFDDGSGDDERPRRPWYRRGWAIGLSALVALGLIGGSALVVIAPWKSDSGDDVRTIRTSTPRGMVVDSDGNLYLSDVSNRQVRKVSPTGRISVFAGTGPEVTAGSGGDDGPAVKAQLAFPQSLAIGPERSVYIADTAEGRVRQVTADGKIRTVVGAKPTAEEEDDAADAQAAQLPNFFVIATSRTGQLYIAESGSGTQRVRRLNTTGGLSTVVKNATNDEGETNSDADAIQSIRSIAIGGDGRIYVADRGHKLIWGFEPGDDTPDAVAGGGTLADCPSKIVYNGPDTLAIGDGGELYVGSYGLCELKDGGSARELVKSQYIDAVAAGRNGDVYYLSKNTIYKRTSAGVVTEVEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSM8</accession>
    <name>A0A010ZSM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative threonine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851125.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079569_3_0_11"/>
    <dbReference type="OrthoDB" id="1927576at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="210" mass="21898" checksum="EDE5CCFBB2C4366B" modified="2014-06-11" version="1">MSVTSSLLSFAAVAALLTIVPGLDTAYVLRTALVSGRRPAFAAALGIGTGSLVWGAAAAVGVSALLTASTVAYTALRVAGAAYLVWLGVQMIRSTLRRRDPDAPGGPGDAVSSRRAWWRGTLTNLLNPKVGAFYLAVIPQFLPEQAPPLLMGVALALVHNAEGMLWFSALILAAHGVRGWLRRPSVHRAIDRVTGTALIGFGLKLAVSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSR5</accession>
    <name>A0A010ZSR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034173_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13068" checksum="8564AE73F92C9328" modified="2014-06-11" version="1">MGAPHEPKKVAMPDVVYALYGDPGTRADRQPRWVVCADQLPAALAALHQCGLCELEVRTGDGRPLAPADLATRYVGTDEFCGFHVFEAAVTFDGRELVRTRYAVPDCACTAMPHRLAGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT54</accession>
    <name>A0A010ZT54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851337.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2955"/>
    <dbReference type="HOGENOM" id="CLU_114921_1_0_11"/>
    <dbReference type="OrthoDB" id="1693553at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="15219" checksum="3A4120BB46149A36" modified="2014-06-11" version="1">MASFNDTVIENFRANDGVLGGHWEGKETLLLHTPGRKSGKNFVNPLVAAPFEGSYIVCGSGGGVPEDPQWVANLEAVDGPVTVELGSRTVQADVRVVRPGRDDDWEKLYGVWREYWPDAADYETKTDRKFPVAVVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT67</accession>
    <name>A0A010ZT67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570224.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032709_0_0_11"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="375" mass="39838" checksum="9214849B1BC72AA6" modified="2014-06-11" version="1">MDTADEFCRLACLTYSGDDGPQRWDTAARLLAEEPGLTRGHVWAAAAAARADEVSALLDADPSTARAAGGPFGWEPLLYLVYSRVPGGDAVAAARSLLAAGADPNSGFVLAPNTFSAITGVFGSGEQNQPRHPRWRELARLLLDAGADPNDEQALYNCMFGASDEHLELLFSAGLADRGLLRIQLRWAVEHDLRDRVRLLTEHGVDVRSPYEGDGPAWAAGDGRTPVALARLCGNTEIADYLLAHGAEPPPPDPVADLIAAVFRGENATAPADVVARAVRERPGLVVWAAAAAPAAVERLVELGFDVNALGRADAPVEQEWETALHHAAGAGDVDLTRRLLALGADPGVRDRRFDATPLDWARHLNRAATAELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTJ4</accession>
    <name>A0A010ZTJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase family protein with metal-binding cysteine cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851539.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3115"/>
    <dbReference type="HOGENOM" id="CLU_001338_2_1_11"/>
    <dbReference type="OrthoDB" id="9107at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="896"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1540" mass="167586" checksum="21C72564DEDA80E6" modified="2014-06-11" version="1">MTATIDPLETAHHVGAAYRRYLSSMQPVRDPAIRSALAQQIAGGHLLKGPFLEATPPYVQAASIDELVASGVLAPGIRAFTGPHLPPDRPLYAHQEQAVRKAAWGRNLVVATGTGSGKTESFLLPILNALASEAARGPLTPGVRAILLYPMNALANDQMKRLRALLSGAPEVTFGRYIGETRQRRADAQEEFLARFPGAEPLPNELLSREEMRASPPHLLLTNYAMLEYLLLRPADVELFAGPFADTWRFVVVDEAHVYDGARGAELAMLLRRLRDRVAPERELQYIATSATVGDDAAAAVRFATDLFGTPFHWVPGVESAQDLIRPSRLPAPAGSFWGPLPTAAYAELLDASDADARLVAYAASAGFAAPDAATALAHEKRFASLQQLLARGPQDVGSVLAELLADVADASHVLDAMVRLAAAMRHPDGSAVLSARYHLFARATEGAFLCLGTEAPHVSLARHTVCDQCENAMFEFGSCRRCGEVYLAGTEDDGRLRPRRATDPNTVWLALAAGRSGEDEDDATLDDGSGTALSDEESGLCLRCGALHSAPRTRCGRSGCSGVVTATRRLATRRSGTLGGCVTCGARGEHSIRLFETGSDAATAVLTTAVYQSLPPAEGDDADYPGEGRKLLLFNDSRQAAAFFAPYLDRTYQRLQWRRLIVLGLRRARSFDDEPVSVDDLAFHLAKEADRFGFFSRRMTGQGKAREALRWLMAELVSTDDRQSLEGTGMMRLALDLGRGALPAPLMTGLGLTDSEARDVVAELLRGLVRQGVLTMPENVDPRDEIFAPRLGPIYVRSKGPDAKRKVLAWSPASSTNRRIDYLTKIAAATGADSDPAELLAGIFRWLAAQRDGALSSMSDRSLGVVHQVDHSALRISAAAELFRCDRCARLAPTSVRQVCPALGCSGALQAWSPDDEDDDHYRTLYRSMDPVPLHAMEHTAQWRSTVAAEIQHKFIQGEVNVLSCSTTFELGVDVGDLQAVMLRNMPPTTANYVQRAGRAGRRTSSAALVVTYAQRQSHDLSQFARPEQMIAGQVRAPYIPLANERIDRRHAHSVVLAAFFRWAKEQHGLEWSTIGDFVLAGPDGKRAIDLVARYLAPPPQPVVDALGRILPADVAREIGVGTGEWIERLLDLLDAVRVEVATDVEFFTDLERVAGAERNYTLARRCQEVVKTLAGRNLLGMLATRNVLPKYGFPVDSVELRTQYLQDQKLRSQLELSRDLSSAIYEYAPGAEIVAGGKLLRSAGIYRLPGRELPSKYYDECTVCGAYRESLAPLDPVCDLCGTHRRGKPRQYLVPEFGFIADRATTSTSDSPPRRSWHGATYIVDQSPESTERIVDLPSGDKATVFSGPRGTLVVVADGVRGAGWLLCRRCGWGTPQGIGKLPRSHPDLRRSDQCDGTLELRSLAHRFQTDLLTLDLPGSGQLPVSAWRSALYAILEGASELLRIARDDVDGSLDPRSDGRPDIGLFDTVPGGAGNVLRIGEHIGQVLRIARNRVAECECGAETSCYACLRSYRNRRYHDELSRRGALSVLEPLVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTY5</accession>
    <name>A0A010ZTY5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851763.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2805236_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="67" mass="7255" checksum="843449D97C33B7DE" modified="2014-06-11" version="1">MHAERVQAEAKIRELTGRQRMTSEEINALVNALGGLRRIPIDADPIDRAQVYRSGRVAGTANGLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU57</accession>
    <name>A0A010ZU57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570377.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3336"/>
    <dbReference type="HOGENOM" id="CLU_079903_0_0_11"/>
    <dbReference type="OrthoDB" id="290698at201174"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="27654" checksum="12F31EF21F26675D" modified="2014-06-11" version="1">MAWSTRELAELAGTTVNTIRHYHRLGLLEEPERRHNGYKQYGVEELVRLLRIRRLVNLGVPLSQVGAVSTNGDLSPNVLRQVDADLAAEAERLRRARSDIAIILGDGAPADGPAGSESVGPRLSAADRSLIHVYTQLYDEEAMKDLQRMIEADTDPVSAALKSLPADADEETRSDLAERLAPVLAQHLIDYPWLSDPAAHLSKSEHVTRDTFINAVVSLYNTAQLDVMGRASVRATELLRARLADADQHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU59</accession>
    <name>A0A010ZU59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849770.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1789"/>
    <dbReference type="HOGENOM" id="CLU_045717_5_1_11"/>
    <dbReference type="OrthoDB" id="833478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="34520" checksum="9B23A27D1C393544" modified="2014-06-11" version="1">MPAVTVENPLVLPRIAPIDPAADRPRLVTSVTTAPQGYEGEGFPVRRAFAGVDLRALDPFIHMDQMGEVEYGAGEPKGTPWHPHRGFETVTYMIDGEMAHQDSNGGGGLITNGDTQWMTAGGGILHIETPPEHIVASGGLFHGLQLWVNLPRTLKFAPPRYQDIRGNKVALLSSDDGGALLRVIAGELDGHAGPGSTHTPITIVHATLSPGAAVTVPWRPDFNALVYVLGGDGTVGAKQRPIRTGQLAVLEDGDSITLTADAKQDSRHPNLDVVLLGGQPIREPVAMSGPFVMNTRAEVVQAFEDFRAGRLGSIPAAHGDVSGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU67</accession>
    <name>A0A010ZU67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.399</ecNumber>
            <ecNumber evidence="7">1.1.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="6"/>
    <dbReference type="EC" id="1.1.1.95" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849782.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1794"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_11"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="42561" checksum="B0E3E4951BB61652" modified="2014-06-11" version="1">MLKALLLENLHPHAEAILGAAGVEVDVRSGALDESELIDALSGVHLLGIRSKTQVTEQVLEKAPDLLAIGAFCIGTNQIDLVSAAGRGVAVFNAPFSNTRSVVELALAEIIALTRRLTEKNNSLHEGVWDKSAEGSHEVRGRRLGIVGYGNIGSQLSVVAEALGMSVGFFDTADKLALGNARRYTSLDDLLDWADVVTLHVDGRSGNAGLFGEAQFARMRPGAIFLNLSRGFLVDMEALRAHMVSGHLAGAAVDVFPEEPKKRGDEFHSELRGLPNVILTPHIGGSTEEAQEDIGRFVAGKLRSFLETGSTTLSVNLPPLNLDQTPGTHRLAHLHRNTPGVLATVNRILAEHGVNIEGQLLNTRGELGYVVTDIPGVLSDDVLAALESMPETVCLRQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUB3</accession>
    <name>A0A010ZUB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849851.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1834"/>
    <dbReference type="HOGENOM" id="CLU_083287_15_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="14236" checksum="D4F29292B14AAD8D" modified="2014-06-11" version="1">MLGEELYVRIARLHRLIATDVVAGPSVAQARTLGRLLADGPQRVSALAAAERTAQPSMTALVDRMEKAGWVTRAPDPTDGRAVTVTVTERGAAEVAAVRVASGRALDERLALLSETDRTALRAALPALDVLLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUU2</accession>
    <name>A0A010ZUU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_2072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850118.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2037"/>
    <dbReference type="HOGENOM" id="CLU_047835_1_1_11"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="220"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="37026" checksum="483A9082F13DB8FB" modified="2014-06-11" version="1">MTTTTDMTGLRKTAILLVQMGKEASSKILAQMRENEIEELTAEIARLGQIETETADDVLFEFHDLATANKYAGQGGLDYARDLLEASVGAERAADLIGRLSKSIADVPFNFLQRAEARQLLSFLQDEHPQTIALVLAHMTATQASGILSGLSPTLQADVANRIAVMDRTSPDTIRQVEETLERKLSSVLQPTEMSVVGGLQPLVEIINRADRGTEKMILEGLETLNPELAEEVRSKMFMFEDIIGLEDRSIQLVLRQVESADLATALKGVNDAVRDKIMRNLSGRAAENLADEVEMLGPVRLRQVEEAQAKVVQNIRALEASGQITIRRGDDDEFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV28</accession>
    <name>A0A010ZV28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570577.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124855_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="18551" checksum="CA0D9DD3C3F4CC4A" modified="2014-06-11" version="1">MTYVVAALAVTNALTLLNLLLLFGVIRRLREQGDTPPGGLPGPRALPVGAQIEAFTTTDTDGRPLLRNELPHGAVIGFFSPGCTPCEALLPKFVSYAERLPGGRQSALAVVVGTPEEAAGYVDRLSPAARVVVEDVTGGVVKRAFGVTGYPTVFQLDGDGRLLVSDASSVDRLAVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV91</accession>
    <name>A0A010ZV91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2202"/>
    <dbReference type="HOGENOM" id="CLU_013325_8_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="126"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="40174" checksum="9EA6346E3A1CC04A" modified="2014-06-11" version="1">MQRPRIKPEHAANRISDGRIRLGGHIYGVAAEVDDPSGAVWTLLESMDGHRDVEQIVSRVRAAHPTESEESVRAGLGTFVGSGYVEDLGAPDPPELTELDKDRYSRSRAYFRWLDTTPRVRSWEPQVALSRARITLIGLGGTGGTAAMALAASGVAQLRCVDPDVVELSNLNRQVLYGEADIGRPKVEAAADRLAQLNSAVDVVTFQERVTGSADVERLVADCDVLVLSADRPTALRRWTNRACLATGTPWVDAGYHGPMVQVGRYVPGVGACWECIRTVDNDHYREIDVNLRDAEPRNEAVADAVAAPTAGISGYLAAHHAMALITGVPSLPAGRIDALNLLAPEATFVRDDPRRPDCPACGTTDAARTGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVF8</accession>
    <name>A0A010ZVF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kup</name>
        <name evidence="12" type="ORF">CryarDRAFT_3879</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852617.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3847"/>
    <dbReference type="HOGENOM" id="CLU_008142_4_2_11"/>
    <dbReference type="OrthoDB" id="589903at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="646" mass="69538" checksum="FE8D9F7D9A9C8976" modified="2014-06-11" version="1">MNEQEQPTPAPAKRRRDVVRLGVVVGALGVVFGDIGTSPIYTLQTVFSPSDPHPVPVSANNVFGVVSLVFWSVMIIVTVTYVLLAMRADNDGEGGIMALITLLRRIGGPRTARTSAVLAGLGIFGAALFFGDSMITPAISVLSAVEGLKLVEPSFDEWVVPITAVIIVVLFLVQRRGTAAVGRFFGPVMILWFVTIGALGITGIARHPDILEALSPTYAIGFLAGHFGIAFFALAAIVLAVTGAEALYADMGHFGRRAIVRGWLFLVLPACVLSYFGQGALILQDTANLSGPFFLLAPEWARLPLIVLATAATVIASQAVITGAYSVAAQAAELGYLPRLRIAHTSTTTFGQIYVPWINWLLLASVLTLVFAFRSSAALAYAFGMAVTGTITITTLLFFYVAHLKWTSVPTWLLAAGGSTLLLVDALFVAANLTKLVHGAWLPLLIALTAFTIMTTWQRGRAIVTAERNRQEGSLTEFIEAMHSETPPITRVPGTAVFLNRGRTTAPLALRANVEHNHVRHEHVLILAIETLPVPRVPAADRIVVDSLGHTDDGISFVHARFGYADTPDVLGALRRIAPDAIERPLDVDGASYFLSKIDLRLGTEPTMARWRKRLFIATSYITADAAEHFGLPRDRTVIMGSHVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVU3</accession>
    <name>A0A010ZVU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852718.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3951"/>
    <dbReference type="HOGENOM" id="CLU_010194_15_1_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="23806" checksum="480BEEA0804633A7" modified="2014-06-11" version="1">MTSTLVIGGSGGVGRVIARRFAERGDDVVITSRDKARADEAAAEVGPRTGTLALDLARPETIEAALAGVTAVDNLVITAVGQAPNTLANLNVPDAIAAVTMKLVGYAETVRVLRDRFTPGAAVVLFGGLAKERPYPGSTVVTTFNAGITGLVRTLAIEIAPHRVNALHSGLIGDSPKWRDVPNPPHADRTPIGRLVTMAEIADATEFLLRNTGMNAHDLYVDGGILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVU7</accession>
    <name>A0A010ZVU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3956"/>
    <dbReference type="HOGENOM" id="CLU_034004_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="180"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="41955" checksum="B7DE145247764880" modified="2014-06-11" version="1">MSIDELVGLVEHDAKNDPFPVNGWDAVVWSVGNATQTALFYQLVFGMELVAYSGPETGNRDHHAYVLRSGGVRFVFKGGVDPASALLDHHRRHGDGIVDIALEVPDVDRCVEHARAEGATILEEPHDVSDEHGTVRVAAIATYGETRHSLIDRSAYRGPYLPGYVARTSGHPSPKRVFQALDHVVGNVELGRMDEWVAFYNRVMGFTNMAEFVGEDIATEYSALMSKVVASGNHKVKFPLNEPAAGKKRSQIDEYLDFYGGPGAQHLALATNDILRTVDALRARGVEFLATPDSYYEDPELRARIGEVRVPIAELQSRGILVDRDEDGYLLQIFTKPLGDRPTVFFEFIERHGSLGFGIGNFKALFEAIEREQALRGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVX9</accession>
    <name>A0A010ZVX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">CryarDRAFT_2478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570068.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2441"/>
    <dbReference type="HOGENOM" id="CLU_054919_3_1_11"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="185" mass="20805" checksum="B2F7D8780CC1E9DF" modified="2014-06-11" version="1">MNDQIRAREVRLVGPEGEQVGIVPVAEALRLAQDTDLDLVEVAPTARPPVCKLMDYGKFKYESAQKAREARRNQSLTVIKEMKLRPKIDPHDYETKKGHVVRFLKAGDKVKITIMFRGREQSRPELGFRLLKRLADEVTELGFVESAPRQDGRNMIMVMAPHRALKTVGQRGSGEDTEADAPADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW43</accession>
    <name>A0A010ZW43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="41476" checksum="D8C086FB436B893A" modified="2014-06-11" version="1">MLKVGIRRPSRVTGDRRLLQATALVSTLDRFAMPPMLIAIARDLDAPLARIVQAASVYFLAYGLMQPVWGLISDRVGLVRTMRFALLIAGLATAVSALVAGPLSLALARGVAGGTFSAGIPAGLVYLGDTVPPADRQREITNLMSGSAIGTALGASGAGIVAQLASWRVTFLITSVFAFVLVLGLRWLTPPPRDRQGQRLGAALGQVARSRWALLVLLLAFGDGVVLLGVLTLLPAAVEAAGTGAALSGSVTAFYGLGMLVFARVAGSLSRRLGRWQLPSLGALAAFVGCALVAVTQTPVAAIVVALLLGLAWAWLHSTLQTWVTEVLPAVRATVVSLFAGALFTGSAVAALLASGPAGRGEYGSVFAVATVLIVPVGVAAGIGRARWRPPGGQESYRSTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWB8</accession>
    <name>A0A010ZWB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_4170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853071.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4145"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="40988" checksum="E52373E8923CB110" modified="2014-06-11" version="1">MTFDLFRLSDDHEDLRAAVRDLVADKITPHAAEVDATASYPHEAQAALVAGDFHAAHVPEEYGGVGADALAVCLIIEEVARGCASSSLIPAVNKLGSMPLILAASEDVKQRYLAPLARGEGGFSYALSEREAGSDTASMRTRATRDGDEWVLNGAKAWITNAGVSEYYTVLAITDPDGRRGANATAFVVEKSDAGVTFGAPERKLGIKGSPTREVLLDNVRIPDDRRVGDVGDGLKIALRTLDHTRVTIGAQAVGIAQGALDVATAYVRERKQFGKRVADFQAIQFMLADMAISLEAARQLVYVAAAKSERGDDDLPFFGAAAKCQASDTAMKITTDAVQLLGGAGYTQDFPVERMMRDAKITQIYEGTNQIQRLVAARSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWE9</accession>
    <name>A0A010ZWE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853138.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4175"/>
    <dbReference type="HOGENOM" id="CLU_131518_2_2_11"/>
    <dbReference type="OrthoDB" id="1980002at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="11003" checksum="91FAAD7BE6ADDB29" modified="2014-06-11" version="1">MEADRRTTADQLTEVRSAIDALDREIVGLLARREEFVRRAGRLKADSDAVRAPARVEQVISKVRGLAAESGADPAVVEATYRAMIAAFIDLELRVHRTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWW1</accession>
    <name>A0A010ZWW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570157.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_36_1_11"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18014" checksum="DD13A1AEB57BB477" modified="2014-06-11" version="1">MEPTIRLGGAELVPDVEHLWKALHAHHQKGLPDLAYHSPDASWAVRSDEYREWLARPGSFVLVAYSGVVPVGYALVEIVEGPEDTWVSGDRIAHLQSLSIAPGWRGTGLGTALADRVDAELEARGVHDLMLDVVEGNVGAERFYERRGLRKVMTIYARFSGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYC0</accession>
    <name>A0A010ZYC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851860.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_5_0_11"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15995" checksum="67E15DC59FF3A977" modified="2014-06-11" version="1">MTDRSVITSTFTLERDYPVPPTTAFAAWADPATKREWFAPTADHYELDFRIGGREANRSEALTFTSTYHDIVPGERIVYSSALADGDRPVTVSLTTVQFFPDGEGTRLLLIEQDSFLDGHEDPAWRERGTANWLDALAAALKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZC5</accession>
    <name>A0A010ZZC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852432.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3731"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="256" mass="26244" checksum="FCBBB55CB464E60E" modified="2014-06-11" version="1">MTRRHDNKVAFVTGAGAGIGRAIARNLAAGGARVVVTDIDGAAAATVASGLADDGADAIAIPLDVRDAAQIDAAVARAEEAFGAVHLLANNAGVVTDHSLATLTEEAWDFVFDVNLKGQFLVARAVAAAMARTGGGAIVNLSTIEALVVVTSGSTAQPHYNASKGGVPMLTKALAVELAGAGIRVNCVAPGPIATDFFDFETVTSEAGLEFMKQRLLIPRVGRPEDIAQAVSFLLSDEASWIDGVQLPVDGGWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A039</accession>
    <name>A0A011A039_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of various ABC-type transport systems with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852820.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4011"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="25209" checksum="CF99A3F1384B02BF" modified="2014-06-11" version="1">MSELRFEDVTVRYGRHTAVDGVSLTVPDGAVIGLVGESGSGKSTLARAAVGLAPLAGGRITLDGAPIPTRGRRPLQMVFQDPYSSLDPRMTVGATIAEAMPRGADRKAGVAHLLEQVHLDPSTARSLPSRLSGGQRQRVALARALAADPQVIIADEITSALDVSVQGAVLNLVRELQGLSMLFISHNLAVVRYVASHVAVMRNGRLVEHGPTAQVLAEPEHDYTRELLAAVPGRRSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A074</accession>
    <name>A0A011A074_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852916.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4058"/>
    <dbReference type="HOGENOM" id="CLU_061369_0_1_11"/>
    <dbReference type="OrthoDB" id="1933111at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="24698" checksum="620EE76E61A8F0C2" modified="2014-06-11" version="1">MTVTEVLAELRALEDPKVRAVNEKHGDDHGVNLGRLRAVAKRLTTRHDLARELWATGDSAARLLALLICRPKAFDHDELDAMLRASRTPKVQDWLVNYVVKKSPHADALRERWWHDPDPLVASAGWALVTERVAKKPEGLDLAALLDELEAGMKDAPDRLQWAMNHCLAQIGIEHAGHRARAIDIGERLEVLKDYPTAPGCTSPFAPIWITEMVGRRDVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABR0</accession>
    <name>A0A011ABR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848140.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791588_0_0_11"/>
    <dbReference type="OrthoDB" id="1997759at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="37578" checksum="ACB9990F6A76124F" modified="2014-06-11" version="1">MNEATLRELLHDVATEVPMHTAADSYVAASIAQRQRLMRHRLILVGAAALVAIVTLGSVAMAFVTDSSSVPPATPVPVSPTPTVVAPSAFDPAQLQVTPVWLPAGLDHWRVEQEPKGARYTATTGGGFQDSAQRVIVYVAPRNTGVPDLEPENKPMRRTTGPGPTINGSETTWIPRETSKGVRTWAGELRFRWASGAQASVDVRDMANAKELAVRIAESLRVTVDRPTPLPFTSIKPKVPLTRLDIRSGGGTSSIRAMYLARAGVGPGVEFQLNMGGSAQPTTQIGPYAVSKTAVSSGEYHYYFTADTNTKVMAVSRPEPGRTQAGLEFAERAIASFEMTGDIREPSSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC17</accession>
    <name>A0A011AC17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, permease component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848318.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.609"/>
    <dbReference type="HOGENOM" id="CLU_016047_3_2_11"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="29277" checksum="88594775DC68510C" modified="2014-06-11" version="1">MNRRRKQSLFRWIVLVVLGVFFLLPLYAMLEFTTRGADGRTAEVWKTLVNWGQIQEDYPDLSIGIIYSLEQAALTAVLMLVLLVPTMVWVRLRLPWLRRPMEFLCLLPLTIPAIVLVVGLAPVYAWVTYLISGSSLWLTFAYVILVLPFAYRALDAGLAAIDVKTLSEAARSLGAGWGTVLWRVVLPNIRSAVLSAAFLSVALVLGEFTIASLLNRENLQVAINLLGKSSATISVAVSLVSLVLAFILLFALSFVGGRRRSKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC22</accession>
    <name>A0A011AC22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848327.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.614"/>
    <dbReference type="HOGENOM" id="CLU_111589_0_0_11"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="157" mass="17109" checksum="8482F28279E35AA4" modified="2014-06-11" version="1">MADARVTVDLTVRDLLHEDLAACAWTGSPTHLRFISAALGRRSAGVVDYLAVCGPSDLPLGVGGVDYGRSRGAGWLWQFVVHPAFRSCGIGTLLVRSAEERIRRRGLSHAELGVDAANAGARRLYARLGYDVVREQGEEWDGRRSHCVVMRRRVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC71</accession>
    <name>A0A011AC71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569685.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.668"/>
    <dbReference type="HOGENOM" id="CLU_094600_0_0_11"/>
    <dbReference type="OrthoDB" id="1962568at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="185" mass="19114" checksum="06E79F9C0B9B3CAE" modified="2014-06-11" version="1">MKLGYAGLAAGPLYVGVSLIEAATRDGFDPTRHAWSQLANGDLGWIHRANLVLSGALTVLGALGLRVRWVRTGIALYGAGLIGAGIFTADPGRGFPVGTPETVEVTTHGILHFVCGGIGFIGLVAACFLVRGAISRFTGALFGVTFVAMAATGGAGWALLAFTAAVILASAWLSILFWKEIRCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACR9</accession>
    <name>A0A011ACR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphate kinase 2, PA0141 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848621.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.871"/>
    <dbReference type="HOGENOM" id="CLU_048699_3_0_11"/>
    <dbReference type="OrthoDB" id="953793at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="32538" checksum="ADC44B0EE1996A41" modified="2014-06-11" version="1">MAKREPDVDEQTEPARVGKKVYEAELLRLQTELVTMQAWLRQSGSRLLVIFEGRDAAGKGGTISRVSQYLNPRYARTVALPAPTDRERGQWYFQRYAQHLPTTGEAVLFDRSWYNRAGVERVMNFCTEDEYRRFLHQCPLFERMLVEDGILLRKYWFSVSDAEQQRRFEARLDDPLRRWKLSPMDVESIARWEDYSRAKDEMFVHTDIPEAPWYVVESDDKRSARLNMIAHLLSTVPYQHVSEPKIKLPKRPKSSGYQRPPRDSQRFVPNHAATLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE22</accession>
    <name>A0A011AE22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849086.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_4_0_11"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="103" mass="11053" checksum="84275F9B4BA72C02" modified="2014-06-11" version="1">MGKFLALFNGAADEADKDELSAQQQAEFLDAWAAWAQADHGALVDPGAPLNAKKRVTARGVEDFVDATTGYEAGSHDEAVRIFAGHPHLRLFEGNSIAVVECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE61</accession>
    <name>A0A011AE61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.130</ecNumber>
            <ecNumber evidence="9">2.1.1.151</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="9"/>
    <dbReference type="EC" id="2.1.1.151" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849142.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076014_2_1_11"/>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="234" mass="24373" checksum="FE5BDA6E2DEBB63D" modified="2014-06-11" version="1">MKLIGVGVGPGDPELVTVKAVRVMRAADRVYVPVLSADETGYAELTVRTHVDHDRLERLVFTAGDPDGAADVVARFLQSVGPGGSAVFATIGDPNVYSAFTQLAQAIRRLLPEVAVETVPGVTAAQDLASRCRVPLVEHGESLTLLPLGTGVGGLSDVLDRPGSVVVYKSGRHLIGVKEAVRRAGRLHGALYGARLGLPGEEVRPLASADGSTAPYLSSVLVPARRTGVRSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEC0</accession>
    <name>A0A011AEC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1433"/>
    <dbReference type="HOGENOM" id="CLU_038663_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="549" mass="60967" checksum="97C239CF8FFDDCC1" modified="2014-06-11" version="1">MISGVSDRPTKRPNRELYLDALRTAAIIRVVTYHTFGGSWLSWLFPAMGVMFALAGGLMVRSLDKQPPLTVIKNRARRLLPALWLFGLIIIPVMIWGGGAFSNWTDPNTGEPVPFWKLIFWVVPIFDPPGNEFGTNFTVVLWYLRTYLWLVALSPLLLKAFRKWPVPTLVAPLGLVLLQAFGVLPSPDEGNLWDLVSTLGMFAPCWMLGFAHRTGKLKKVPMPALIALVAACAIGGIAWALGHPAQDADAGEAYDLNGIPLANALWSIAVIIPLLRFAPDASWIGRTPFLGRLVALVNNRAVTIYLWHNVMIDASYPIDDWLTRWLPEGLVENPAWDFLTVWVLVALCVLAFGWVEDLAARRKPRLFPVGPSAAERRAEHAAELAAKAAEDTPAPVAANAARPGDDQRPYGGPDQYGAPDRYGRPDDRYGRPEQHGRPDPYGQGQYTQPDRYPQQRPAGPAGHPQNGHGTPDAHRYQQYETGQYGAPLGGYDHPTADYNAEYRNVANHPTADYSEAYREARREPPRRNGYPAQRPPAEGQPEEPRRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF80</accession>
    <name>A0A011AF80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849704.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1741"/>
    <dbReference type="HOGENOM" id="CLU_099824_3_0_11"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="16001" checksum="820FBDE198966226" modified="2014-06-11" version="1">MDVLVLNADLGPLHRVSFRHAVRMLVRRVAEVHESHPGRLVGSYPAPRVVRLVTYVVTRWRHSRGPGWSRPGVLVRDRRCCAYCGRPASTVDHVLPRSRGGANSWANTVAACGPCNHRKGDRTPAEARMPLRFAPAAPTWAALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFC6</accession>
    <name>A0A011AFC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GSPII F domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849755.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1778"/>
    <dbReference type="HOGENOM" id="CLU_079642_1_0_11"/>
    <dbReference type="OrthoDB" id="1835396at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="153"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="30231" checksum="79B047DB85F7D0D5" modified="2014-06-11" version="1">MIAAWQLPAAVLGGAAIGGGAFLLVREALPAVPALGPALRRLHASPSVAPVSSPSLLSGVARRIRVPSRDLALLGRTREQYLLSLLLSALIGLATPPVAGFIFAAAGIRLPVAIPVAAGLVFAVLFVVVAHRDVVEKAASARAEFVRAVCTYLDLVALQLAAAHGPVQALEQAATVCDGWVFQRIREALVRAQLQMRFPWAELRLMSQEIGVAELGDVGAIMQSSGTEGAQVQHTLREQADSLRDQIRTTDLARAESITSRLDIPGAALVFVLVLFVLYPFMTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFQ9</accession>
    <name>A0A011AFQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="14">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CryarDRAFT_1956</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569971.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1920"/>
    <dbReference type="HOGENOM" id="CLU_036876_3_0_11"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0186">Copper</keyword>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="18">
        <location>
            <begin position="38"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="137"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EXG80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="299" mass="33099" checksum="1A3BC52547D808FA" modified="2014-06-11" version="1">MGANPSASAERRSRRSRAGRIVAVTGIAGASALLLSGCSTEEVLRFGWPKGITPQAEQMMDLWTGSVIAALAVGVFVWGLIFWAVIRYRKKSDELPVQTRFNLPIEILYTAVPFLIIAVLFYYTAIVQTYVDKQKANPDVTVSVVAFKWNWQFLYPEELDTDRQPIGTVGSTEEIPVLVVPTGQRIRFVETSNDVIHSFWVPALLFKRDVVPGRTNSFEATINSGEEGAYVGRCAELCGTYHANMNFELRAVTPEKFDQFIEAKKTGASTHDALQQIGESPVATTTTPFNTDRTARQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHX2</accession>
    <name>A0A011AHX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851003.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2691"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="366" mass="38061" checksum="A0B51041117B5C6D" modified="2014-06-11" version="1">MAEEIAGGDLSRLRQLNSLTMVRVLRAGEPATLTELAARAGLSRASTEDVVGALVAQGWVAEVPPVAGAMGRPARRYRFRGDAGHVLGVDIGGHRVRALVTDLDGTVLGRAQTAVAETAGRATRLAAADSVVSEGLRAAGLPAGELWAVGVASSGLVDPGGRVVLSVAIPEWTGLDLAQHFGTTFRGPVVVDNDSRLAALAEQWRGVARYAKDFVHLLAGLRTGVGLVIDGKLHRGFGGAAGEIGALPNVGWIRAQEHLQAWDGEAADLFAAARAGDRSALGAVRRYVRDLSVGTAALVLALDPQMVVLGGGFSRSADVLLEPLRKELDKHCIRTPEVLASTLGEESVALGAVKLALDHVQPQLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI93</accession>
    <name>A0A011AI93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2792"/>
    <dbReference type="HOGENOM" id="CLU_921059_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="31448" checksum="21E2FB4788B0C7FC" modified="2014-06-11" version="1">MSARVLVAGWYSFLHGEATAGDVLAGEAVTAALDTLGREYDVVWSPGFRPGALHVEDVDPARYDTVVFACGPLHSNPPAPLLDLHERFAHCRRIAVGVSVPDPSDPAVTGFHVVLARDAAGHEPAADLALAAPEPGAVPVVGVILTDGQHEYGVRRRHESVSAALTGWLHGLDVARLPLDTRLDTRDWRLAATPGQLRAVLDRLDVIVTTRLHGLVLGLQAGVPVLAVDPVAGGAKVTAQARALGWPAILPADDLSRRDEWWRWCLSPAARHWAAPANTLVTRLIEVLPGVAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIY8</accession>
    <name>A0A011AIY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851499.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2733247_0_0_11"/>
    <dbReference type="OrthoDB" id="2226038at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7647" checksum="42717C3C9BCBCB71" modified="2014-06-11" version="1">MVVHPPADSVDATGYLIPPYDTDPGWTVRIWDRGARIDYPLYIPGGAHAAYYATAADAMDAAVNALRIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK57</accession>
    <name>A0A011AK57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570467.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198177_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="23854" checksum="F1FA1B56EB5EB769" modified="2014-06-11" version="1">MRPLALWRHEFGRAGWITLVAPPLALLAPLALTALGGAERQRLLLAGPEAVLPLAVALAAVSIVARDPVTELHLTLPTRLRATLLRRLALLLLVAGIVAGLYCALLIVFDAWAGPRSTPLPQSLLLWSAPTLALTAVTVAVGGLTRSLTLATTTAGGLWLVEQLFAGVFTEHVPWLYLFPTLRLGVGPDWTASRLTLLAVALVVAVGAAWTLGRPERLLTEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALZ2</accession>
    <name>A0A011ALZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase/fructose-1,6-bisphosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853107.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4162"/>
    <dbReference type="HOGENOM" id="CLU_044118_4_0_11"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="27837" checksum="93018A6949106D3C" modified="2014-06-11" version="1">MNTDLQLARHAALAGAAVGLRYFADLAELPREYKSDGSVVTAADRAVEAAVRAVLADARPGDAVLGEESGPTGTGARRWIVDPIDGTALFVAGDDRWLVLVALEEDGEIVAGVVVVPAQGRIWWASRGEGAFAARYTGDSVGPGQRLQVGRSRPDGLAGSVLGVIPTDDGLFPAEREMLAPLTAVATKTAWGVHAALLVAGGEFDLAVQTRGHVWDFAATSLIVTEAGGCYGGLDGRTRPGRGTSVFARDAGLHAAALDLLVRGTGTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM10</accession>
    <name>A0A011AM10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853187.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4182"/>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_11"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="16496" checksum="80581A3993708282" modified="2014-06-11" version="1">MASHLVTLTVNGAQTELIARPATTLLLALRESLGLTGAKRGCAQGTCGSCTVLLDGAPVVSCLVPLATVDEAAVTTIEGVAGPDGALDDVQQAFLDGFAMQCGYCTPGMIMSAEALLERNPDPTREEVEEAISGNVCRCTGYTPIVTAVLDAARRRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFP7</accession>
    <name>A0A010YFP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847457.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="27902" checksum="3E6E379440483267" modified="2014-06-11" version="1">MLPVLVATDLDGTLIRSDGTVSEYTHGVLRRVRDAGVEVVGVTGRGPRLRTLSAAAVDVSRYLVCAQGGFVLDLETGGVLKATRIAGAVAAQAVAMIEERVGPVLVTVEAGEADHAPLHGDPTFEWPFPDPWEPADRETMFASELLKVFVAKPGLDVEEFFAVARDVVPATVGEVTYAGLGFLEICPTGVTKAAGLAVVCDTLGVAASDVLAFGDMPNDVPMLGWAGKGVAVANAHPELKAVAEEVTGSNDEDGVAHYLEELLPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG78</accession>
    <name>A0A010YG78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081797_0_0_11"/>
    <dbReference type="OrthoDB" id="1472003at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="33262" checksum="65E9FAC69A271860" modified="2014-06-11" version="1">MLTGNQTEFVMLLTIAYTGMRWSEALAIAPGAVRKEELDIHWKLYELGGRFYRGYPKDGSKRTVDIPPFLRQLLANYLGQGRKLRCPCVEREGDDRDDIPWCHGDEYVFLGARGGHHQRSHFSERIMRPAADGWYTGRSNRPRMPVLVDLNQPYPGAILPPWPANDPAAPPHVPQRRRGLRQPPADAALASWLPVLNGLTPHGLRHGHKTWMDEAKIHRSLSTDRMGHEVPGMDGIYGHITPGMRRELLSVLEDLWTTALQQRAAISRSSAVPMLDALLKNSAAPNSLPETEKPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGH0</accession>
    <name>A0A010YGH0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847902.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.353"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="364" mass="38926" checksum="FBB0950B40CB78E3" modified="2014-06-11" version="1">MNRLTIRLRLSLVYGGLFMLSGTLLLCVTYVLVAQRLPAGGEAVRAASPTGEGPAIELVKETADDALSVLLTQGGIALGIVGLAATVLGWLIAGRMLQPLHRVTETARRIADAPNSLHERIEMDGPQDEVKELADTFDAMLERLDHAFDGERKFIANASHELRTPLTVNRALLEVALYRREPTPEVRTLAETLLAVNERHERLVDGLLLLARSERDIGERFHVDLADLADHLVDSLPPGPVTVVPKLAEAPTNGNPVLLERLVQNLVENGLRYNLPDGGTVEVCTGVASGAAFLEVRNTGPAVPRYEVPGLFQPFRRLADRTGSGAGLGLSIVHAVVRAHGGRVTASPGQSGGLVVTVQLPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH18</accession>
    <name>A0A010YH18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848308.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.598"/>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="46175" checksum="204BD7B0DCB0D37E" modified="2014-06-11" version="1">MADRKRIVVVGAGFAGLHAARTAVRSTKGQADVVVVNPTDYFLYLPLLPEVSAGILEPRRITVPLIRTLGGARLVLGDVDGVDTDERRVYFENPEGDRGSIRYDRLIFAPGSVNKLLPVPGVADHAHGFRSIAEALYLRDHIVRQLELASTTSDPVEREARCTFVVVGAGYTGTEVAAACQLFSESAAKHLPNLHRQKIRWLLLDLAPNVLPGLDPRLGTAADEILRKRGVEVRMGTSVAEATADGVKLTDGEFVPTRTLAWCVGVRPDPLIESTGLPTQEGRLTVDAWLNVPDHPDVYAAGDSAAVPDLTRPGEITPMTAQHAQRQGVQAGKNVAASLGFGTGAQYKHHDLGFVVDLSGAKAAANPLGIPLSGFPAKVVTRGYHLLAMPGNHPRVVADWILDAAFRRQVSQIGTVRGWAVPLDTDTGAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH52</accession>
    <name>A0A010YH52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848356.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_5_1_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="26753" checksum="D6402CC9E4B2A951" modified="2014-06-11" version="1">MDVLVVGGTGAAGRAAVVALVERGHTVRALSRSGATDVPGAVGYRADLSTGAGLAEAVAGVDAVVDAFNVTSQSYEVARKAFVGTTERLLAAEVEAAVGHHVLLSIVAIDGSTYAYYRAKEAQEQAVIAGSVPWTIVRATQFHEFAGQLAAQTKFGPFVAIPTFLTRPVAVAEVGGALADAVEAGPSGRAPDLFGPKVESVPDMARRTLKARGVRAVVVPVPLPGKAGAMMRSGVLGGNGVGQQSHETFDEWVRGEPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHE5</accession>
    <name>A0A010YHE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.726"/>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="543" mass="55658" checksum="2DFB9A604EC6657B" modified="2014-06-11" version="1">MAIDGGAVAAAREFAERLHAAPVPRTTEPAAVFSAAPASPKHPTAVRDLATRLDPAGTTGPSDAPPTPAPPGPVPGGDAAPDDDLRTLSGAAAALRRGTVRSIELVDAALAAGDKSDAELGLFLSRFADRAREAAQRVDDALAAGDDPGPLSGLPLGIKDLLTTEDGPTSAGSLVPPPDARRDATAVARLRAAGGIVVGKTLTSEYGVGSPDPAKPLPVPRNPWDTARWTGGSSAGSAAGLVAGAFLGALGTDSGGSIRMPSAFCGTTGLKPTYGRVSRAGGLPMGWSTDHVGPMATTARDCALLLSVIAGPDPADPTTSEVPVPRYLEGLTGDLTGVRVGVDRLDRVGGAVADPALASVFAAALDELTALGAELVEVALPLYPELAAASIVLTLSEALTWHRADFAARGGDFFANTLATVGLAEAFTAVDYVQAQRVRRAGQDAVSALFDAVDLVVTPTASIAATPYDRLDRMFESGEFFAVYAPYWNVVGNPALSVPMGFTADRMPLGLQVIGAPFDEALVLRAGDAYQRRTGWHNEWRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHM5</accession>
    <name>A0A010YHM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848521.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.783"/>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="221"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="35859" checksum="6A1077AF75243EF5" modified="2014-06-11" version="1">MGQAHVVAVAVTGSLPVFELAVACEVFGLDRSDIVDPWYELRLCAAEAGPLRTAAGLGVDTPYDLDDLVAADTVLVPGIHRSTQLDPPEPLLDALRRAYGAGKRIVSFCGGGYVLAAAGLLDGRRATQHWMNALDFAHRFPRVQVDPTVLYVDDGQLLTSAGTAAAIDLSLHIVRQDHGSAVAAEVARRMVVAPPRQGSQAQHPTPLSARLGDPRRPDDLSAVLAWAQERLDQPLAVADLARQAHLSPTTFARRFRTTLGATPLQWLVEQRVRRAQELLETTDEPVERIARLAGFGTPANLRHHFQRLVEVSPQTYRHVFRYRARVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHS2</accession>
    <name>A0A010YHS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848601.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.850"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="394" mass="42725" checksum="A3E50F5CD79C8643" modified="2014-06-11" version="1">MRALTWQGTQKVSVETVPDPTIQQPTDAIVRMTSTAICGSDLHLYDVLGMFLDPGDILGHEPMGIVEEVGPEVTHIRPGDRVVVPFNISCGHCWMCSRGFYAQCETTQNVEQGKGASLFGYTKLYGQVPGAQAEYLRVPQAQFGPIKVESEHPDERFLYLSDVLTTSWQAVRYADTNPGDTVAVIGLGPIGQMSARIAKYLGANQVIAVDNVPERLEMARRHGITVLDEREVDDIPAAIADLTDGRGADGVVEAVGMEAHGTPFQEFAQRAAGLLPDALSKPAIDKMGVDRMGALRTAFASVRRAGTVSIIGVYGGQADPFPMMDLFDKGVTLRMGQAHVKRWVDEIMPALTGADDPLGTEDLRTHSLGLEQAPEAYDMFKDKKDGCIKVVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIP4</accession>
    <name>A0A010YIP4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="2" type="ORF">CryarDRAFT_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860892.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1170"/>
    <dbReference type="HOGENOM" id="CLU_042555_3_0_11"/>
    <dbReference type="OrthoDB" id="693464at2"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="26296" checksum="97A199D87624E92C" modified="2014-06-11" version="1">MCRHLAYLGPAHTLHDLLIAPEHGLYRQSWAPRRQQHGTVNADGFGVGWYAPGDPVPARYRRDRPIWGDPNLLDLARVVRSGAVLAAVRSGTEGMGFAEAAAAPFASDKWLFSHNGAVPGWPGSLHGLAAALPPEYLVGLEAPTDSALLWAHTRFRLASGVPLPVALAETAAAVDAPGARLNLLATDGTTIAATVRGDTLSWRRASPAGVLVVSEPTDDEPGWHHVPDNSLLVATSDAVTVEQLAVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIR0</accession>
    <name>A0A010YIR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1180"/>
    <dbReference type="HOGENOM" id="CLU_021080_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="42995" checksum="FB43C020AEE8186E" modified="2014-06-11" version="1">MFDELPDAVVTLVTAAVSVLVALVVVQIIHVVVRRLGRRAPLFAQVAARLHRPVQCLAAVLAVQGSLHATTARGDWRGPLLHAITVLVIASVAWVVGALLVILEDAALSRFRTDVENNKRNRRVHTQIMVVRRVTVAVVVVVAVGAVLVTFPTARAAGASLLASAGIAGVVAGLAAQSVLGNVFAGVQLAFSDELRIDDVVVVEGEWGRVEDITLSYVVLHLWDDRRLTLPTSYFTTKPFQNWTRNESALLGAVEIDVDWAVPTEEMRRELRHVCEGTDLWDGRACVFQVTDAIGGMVRVRALVTARDAPTLFDLRCHVRERLVQWLRENYPEALPRSRADVTGIPGVRIDKVENLNGRDLGPAAVADAPDDARVFSGSADGRERNAAFAGRSEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIS4</accession>
    <name>A0A010YIS4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848932.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1190"/>
    <dbReference type="HOGENOM" id="CLU_047691_3_5_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="18936" checksum="2D3F75893502BAA9" modified="2014-06-11" version="1">MPDLDDVTEWALRAQHGDALATAAFVRATQPDVWRFCASLVDADAADDLTQETYLRAFRALPSFAARSSVRTWLLGIARRTCADHLRSVVRRRRLDEVLKARFAPVTPDPSGTADATDLLARLSTERRSAFVLTQLVGLSYQEAAAVEGVPVGTIRSRVARARDDLVNALTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJE3</accession>
    <name>A0A010YJE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569857.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2681497_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="74" mass="8063" checksum="04A409C9563E1956" modified="2014-06-11" version="1">MPEPPRPEQPSDDKVLRGLVGAGPSQLSTHAALRARDASQPTDEDLAEAERDLVLVRRRYVPTQNLPPGIKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJH2</accession>
    <name>A0A010YJH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">CryarDRAFT_1458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849238.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1432"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_11"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="14764" checksum="D2E1D47476A30A7C" modified="2014-06-11" version="1">MSERTLVLIKPDAVRRGLIGEVLGRFERKGLSIDALNLRTVDATLADEHYAEHLEQPWYPPLREFITSGPLVALILSGDEAISVVRTLIGATDGRKAAGGTIRGDFSLSNRENLAHASDSPESAAREIKIWFPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKN9</accession>
    <name>A0A010YKN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849835.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1822"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457883" evidence="1">
        <location>
            <begin position="24"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="43399" checksum="648B3FAE5A17B031" modified="2014-06-11" version="1">MDQRRSMVRAAAALALALPLALAGCGGGGSDSGGDPTKLRVLDYYNNEPDKAVYTKVLNACAAENKVTIQREAVPGDTLIQKVLQQSSSRTLPDVLMLDNPDLQQIAATGALSPLSDYDLKADGYVPGVVAASTYKDKLYGLQPVTNTIGLFYNKDILAAAGVQPPTTWEELRAAAKKLTKGKQYGIGFSAPANYEGTWQFLPFMWSNGGDEKNIATPETAAALQLWVDLVKDGSASKSVLNWTQADVNDQFKAGNAAMMVNGPWQFPVLNEDTKLHYDVVPIPAPKAGGTAVAPLGGETWTIPNTGNKDKQKNAAKIVECLNSDENQLLLAKERQTVPTKTSLQDKFVTEVPSMKAFSTLVKDARARTGELGADWPKAATKIYTAVQAALTGGATPQKALQDAQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKS0</accession>
    <name>A0A010YKS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1869"/>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="191"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="409" mass="45625" checksum="A92BC69BC7E88C99" modified="2014-06-11" version="1">MAHIEDRWFTPQHDDDGKLVLNARGKPVMARTTLYGTGLRYRVCYIGPDGRERKKSFPDRAKQAAEAFMATVEADKHRGTFIDPAAGCMLFGEFAETWLRTRTYDKSTMESLEVRVRKHILPFFGSRPLSSIKPSAVAEWDSELAGVLAQDTRSVAFAYLRMILTAAVDDERIAKNPCSAKSVKQPRPVERRVIPWTYDDVSAIRANLLPRYRPVVDLGGGCGMRQGEIFGLGVDDLDLVGGWVHVRRQVKRVYSRLVFGLPKNDKDRRVPLPASIAAALRAHLAEFPTVSVTLPWEDPFGDERVTVPLVFVTSRRGAINRSHFNSKVWHPALAAVGIPHTRATGVHALRHFYASTLLDAGENVRALATYLGHADPGFTLRIYTHLMPSSEERTRTAIDSLFGVPLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL07</accession>
    <name>A0A010YL07_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="196" mass="22160" checksum="761DE875284FB3A7" modified="2014-06-11" version="1">MTAIVGFESLSARPGPFGWTDDMLAEIPEGVRYEIEDGHLIVTPQPIPWHQDAGFIVTAALRENCPRDLIALYECEIRVLNDAGHIVQRRIPDVMVLPRALRERDAERGWIQPNEVPVAAEIVSTGSRVADRITKVGVYAEWGVGLYLRIEREPSVALYEYRLDPVTKTYLTPVEHAEVFETDDPYPIRIELAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNN0</accession>
    <name>A0A010YNN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570177.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2832"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="1851240at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="453" mass="45878" checksum="CEC6B73AA8BB71BD" modified="2014-06-11" version="1">MTTTAEAPIGRREQLVLAVVSAATLLTLADYTAPAVVLPTLAAELHATATAQVWVLNGITFGLAVLLLSAGSVADDYGRRRVFVGGVAGLSLAMVASALAPTAWVFVGARVVQGVAGAAILTAGPGLVADAFPPGPHRIRAAATWGSMIGLGIAIGPLLAVAGGHVGGWRTFYWGAAAVGLVLAVASRPVLRESRAERPRPIDWLGVVLLGAALAALLVGVTNGRTGWLRAATVLPIVLALVLFGLFALRETRAGQPMIDLTLFRRPPFLLATLGALATGVAVIGPMTFLPTALQRGSGWTSAHTAVLAFVWAFTIFLVGLAARRMRATEHGGLELGAGFVLSAAGSVLALLTVGHAWGWMLPGMAVAGIGAGLINATLPRLAVGTVPPDRSAMGSGANNTARYVGSALGVAVTASLAPARPAEALVVGVVLCAVAALALTPLTVRTRVLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNY9</accession>
    <name>A0A010YNY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851352.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2970"/>
    <dbReference type="HOGENOM" id="CLU_094600_0_0_11"/>
    <dbReference type="OrthoDB" id="1962568at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="20705" checksum="A3F27E5396CF2C47" modified="2014-06-11" version="1">MTRTAALIAGPLFVVAWAVQAFTREGFEPGRHPVSLLALGDLGWIQIASFVLTGVLLVLAGITVRPRWGGALIVGFGVGMVVAGVFVTDAGAGFPAGAPAGAPERLSWHGALHELGFLLASVCWTAAAVVFLVHFRRRRRRAAAAATAATLLVVLTLAAWPDADGLPLRLIAATAVQLAFVAVIAATHQPSSSAVAARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP74</accession>
    <name>A0A010YP74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2989055_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="57" mass="5881" checksum="07FCB080C69DF9AC" modified="2014-06-11" version="1">MVTFTGVDLGDLAAILGALINLGIAVAQKLRKERVADRPDDSATGKAVQVSPTDLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPD2</accession>
    <name>A0A010YPD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725717.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3138"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="937" mass="101065" checksum="C7094509A97A3A2B" modified="2014-06-11" version="1">MLRFTILGPVSIRHGDAEAEIGGRQPRVVLALLLSAAGSSVSVSEIVDTLWEEDPPLSAVNVVHRFIGMLRRVIEPDLPVRTAGNYIVRSAAGYRLRADAQTLDLLRFRALAGQARQTVEPDGAIRLYAEALRLWQGPSAAGLETVSRIHPAFLAIDAECSLVAREAADLALRHGLLTPVIPALRRAARLSPLDEALQARLVLALAADGRQSEAMATFHAVRRRLDDELGIDPSPELLDAYERLLHQRALPPSAPADRPSVPMQLPADHPFFSGRAAELVRARALLGEDQRQARPIVALAIDGMPGVGKTTFAVHLGHQLTADYPDGQLYADLRGFSDEGAAMAPAEALRGFLASLGVPLSDLPPELHALAGLYRSILANRRMLILLDNCRDYDQVRHLLPSTPGSLAIVTSRTRLTGLISSGSGQPLPLDLPDRDEARTFLARRLGGERVTIDHVAVDTIVDRSGRLPLALALVAARAAMAPGTPLAEIAAELAPAQDFVGFGPASATHLRAVFSWSYRALTAEAARLFRLLPLHPGPDLTVLSAGALAGVDTRTGAHLLGELTSHLMVQDSDGRYQVHGLLRAYAEYLSERHDAPAQRRAATLRVFAYYQHSAHAAHLRLDPQLPEPVPAPADVTPLQFRTQDEAMAWFTAERQALTDVVRTRMDDARGLAWRTALTMQDFLHSSGRTPDWVDIAHAGLDAATLDGDVGGQARLLRSRAGALFMLRDFGGALRHLRRARRIVESVGDDAQLAAIDINAAYVRGAQRRYADAVGHGEHALAAYRRLGDVRNQAAALRVIAANIAGEGRRDEAVRLLREALTLSNSVDDTRGAGHCWDLLGTIHRQVGDRRSAVVHWHRAAANYRRAGAPAARAAVLLAIGDLHEQSGDRGAGRAAWIEARAALGDSAGPLARVVQSRLVVNAPLTLDPHWFGTAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPI0</accession>
    <name>A0A010YPI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="691"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="760" mass="80177" checksum="66E5CB9C6D28C1F2" modified="2014-06-11" version="1">MSDPALRGRESQLSVLRGRLDALVSGQGGVAVIHGAAGMGKTRLIRDLVALGDQRGVVVRYGRCDVLARSVPLGTLLAALLDGSDLDPEPLRSVSHQPFWLIRAMQDALKRATADGPVLIALDDLQWADPDTLSALIALTESSSGYRVLWLITVRAGSTTPLVAAALERLAANGAIRVEIGPLDLPAVTDITRDLLTAEPGRGLPAAVAGAEAQPLFLVELLRGLREDGSIAVAGGVAELTTVSLPRRVRVLVDGQLRQLTESARHTVQLGAALGRRFTGAELAELAERTPAAMLTTIEEAISAGLFVAAGDDLGFRHELVREAVEASVPATVFSALRRDAIGAPPAEAPAMAARRGRRASRPGRAERDLLLVPRALRAMERLEWRHSLELIGDAVAVVHAQGPGAPHLWRADVWQAHLYLACARPSDALALADSGLAAAQHQGLSGLAPAWSSVRARALLDVGRLADARIAAEDLLAVSADAGHLHDVALYVIGCIGLHTGGPADIERTRAAAERLRTAAQPSTRRLGASLTARLDGVLDPLGELVDAPLLAVTTPWSYSDAVWQVRLLLAAGEADAAQTVAARLTGIAVDRPDFPYLRASAAHARALVHDDAALAAEAAAGHSDDPRLLVRAAAIEDAGRLLPSTARDQAIARLAEALSLYSTAGADLDVARVRALLRQRGVRRTVGSSVTSWPELTDAESTVAQFAAAGSTNQAIAARMHISPHTVNSHLRHIYDKLGVRSRVELTRLVTERAHRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPW8</accession>
    <name>A0A010YPW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851894.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3344"/>
    <dbReference type="HOGENOM" id="CLU_027853_9_2_11"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="369" mass="39252" checksum="2DAFDB77ABBDE001" modified="2014-06-11" version="1">MTRVPLSVLDLVPVSSGSTTADAVRNAVDLARRTEEFGYRRYWFAEHHLNPGVLGSSPSVLIALAAAATSRIRLGSAGFQLGHRTALSVVEEVGLVDALHPGRIDLGLGRSSGRPPSTQATPAPARPSNGLVVPKPFSFARLLGSPRIALHQRLLQLPGAQPPDYGEQIDDLLALLHGTYQYEGVEGHASPGEGADVELWILGSSGGQSATVAGERGLRFAANYHVAPAGVLEAVAAYRAAFRPSEYLDAPYVSVSADVVVADDDATARELAAGYAPWVRSIRTAAGAIAFPTPAEAAAFPWTEEDRELVADRLETQFVGAPDTVARRLLELQEATDADELVVTTITHDHADRVRSYELLAKEWNSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPY4</accession>
    <name>A0A010YPY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3359"/>
    <dbReference type="HOGENOM" id="CLU_409234_0_0_11"/>
    <dbReference type="OrthoDB" id="207739at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="671" mass="68624" checksum="8C724721A26C815A" modified="2014-06-11" version="1">MTPSTLRNRGPRWQILLRLGLVAALLGTVFGVAALGRSGELAGLTMRSATAWLISTRPGLVTRVNGLSAAPETAIALPTVRGHDADTGQIGSAVLVADRKTGEVTRVDTAALQAGQPTPLGREASRLLASPTAAALVDLAAGTVTWVDPATGTPRGESSPLGTPFSDAVITADGTVWVVAPGLGSAIPLRSSGAGSPVPVGDPGEALGLTLLAGRPVAVDAATGVARRVDTADRAVIARLPAGVDPVAAAGSNDGWSLVAVVGSPTRLISVDVRSGRTTTIALPGVDLGDLDEPVLAGGLTYLPDHRRGRILVTDGTGSPPQSVPVTGHAGELQAFAQDGLVWVNAPARPEAVVFSGRVHRPIRKYAAVAGSPEPTATATSSQSPSPEPTKSPPPSAQSSVGPTASASSSKSTDSSGSEPGSSPTPDPGQSSGPEAPSPSPTAAPPASPVRCGATLTESATLDHDLDCTTSIGVIIGANDVTLDLNGHTIRYTSGFAGDERPIGIRITGVRGTEIRNGSVRGFRDYIDIRDAQDVLLSGLDLVDFRVGLRINDSRGVHLERTQVVNADNGAVTVDVANSEIQGTDGTNIAGFQGNCYQSTCTMLDSSIGHRYFYINNGSTFVFRRGQFLNRLTVVYEGCSLTVTDSRLGSGNLGGTGERVLENNTGTINDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ38</accession>
    <name>A0A010YQ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxyacid dehydrogenase, FMN-dependent L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3410"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="378"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="439" mass="47653" checksum="A1024F93FBEE1B04" modified="2014-06-11" version="1">MSNQDDVGPLFRPAPPAVLAPIATVRQIPSWSELREVVQFRRPRLGRTRRRLERSHSIRDLREAARRTTPRAVFDYVDGAAEEEITAARNVAAYRRITFRPDALRSVASPDSSIILLGQRIAMPLMFAPTGYTRMMHHHGEAAVASVAQHVGVPYALSTMGSTSIEDVRAAAPGGDLWFQLYLTANRRLNEELLARAEAAGYSTVLLTVDTTVSGMRLRDVLNGLTIPPTLTARTALNMSRFPTWWFNKLTTGGMTFASLDGIPGKPTPGEVANMLFDPGLNLESLTWLRRRWRGNLLVKGVTTPASAREILEHGADGVVVSNHGGRQLDRSAATLDVLPAIRAAVGLEATVLIDGGVLHGQDIVAARALGADAVMIGRAYLYGLMAGGQGGVLRAFEILAEGYQRSMQLLGVRRSEDLSDRHVAFASHAAGDYPHVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQG7</accession>
    <name>A0A010YQG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell wall-associated hydrolase, invasion-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_1_0_11"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457642" evidence="4">
        <location>
            <begin position="35"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="228"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="37121" checksum="405786BBEF718FBA" modified="2014-06-11" version="1">MRSVRTHARRPIALLGVVVAVLGVVLLPGGGATAAPSPADAARQLHSLGVTMDRLNERANSARAQLRRVEAQRVGLERQRAAAQVALDESRAQVGQIAQSAYRDGGLRLSSSVLEGSPGDFFARMSTLEWLSDQQRATIAAAKQRQSQFDDATARVEGQVRSARRLRARLDRQKTELAARMRRWEKLKEQVPPPRAEPDPENDAPPPRPEDDAPHPDTRRPTDVGPASGNGARVARFALAQRGEPYVFGAAGPNAWDCSGLTQKAWAQVGVPLPHSAHQQYYQIRHVPRSDLRVGDLVFFYGLEHVGVYIGGNRVVHAPTPGESVTVTNLNYMPYAGAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQW0</accession>
    <name>A0A010YQW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3751"/>
    <dbReference type="HOGENOM" id="CLU_420764_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="651" mass="69837" checksum="CE4BEC76B286E8F2" modified="2014-06-11" version="1">MEPVDTVFVVTAVAHLCAVVLLSVELVRGRRLPAAVVPVVCAAAGAGGALLTGRPAASAVGVLVLGAVAVRCAPGLRPSGAVAWATLLVSTAAGTVVGLLHLAGLTVHPVGLVLIWVVALVGVVRTPSSLLQLYENWEIGLRRHWRRSLAPLVDREPGGDAPLVTVQVPIHAEPPSVVIATLDALARLDYPHFEVLVIDNNTGDEELWRPVEQHCAELGDRFRFRHVEGITGAKAGALNWSRPHLDPRTALVALVDADYQVDPLWLRHTVGFFDDPEIGFVQCPHAYRAYEHSAYGRWANTGYEWAQVTEMRSRNEHGAGITVGTMSLIRLETLDAAGGWAEWCQTEDSEFAIRAHAAGYSSVLVDRAYGWGLIPETVAELKKQRFRWTYGPGQEFKAHARLYLPRPLGVPSRLTRAQRIRHGHYGLVVLVTGLGVLSLPVSLVLVGMMFARHDIPDVPAVLLLPLAAGLVARRIMRWTLFRTAVGAGFGAFLGACVALLAVKPTMSGAAFGVLIGRPARWQRTNKFRVLPRRFRFVRDAWSEIVLGAGCLALAIALPLVAPMSVATVVFALGFGWQALVYACAPLLAVLAERALRPGRAVTDHRDAGTGGDPGPHRRVATGGADARDDVGAGPAQPEEKRHPRAASAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRA4</accession>
    <name>A0A010YRA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Amino acid adenylation enzyme/thioester reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_3920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852652.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3889"/>
    <dbReference type="HOGENOM" id="CLU_000022_49_0_11"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1406"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1462"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1495"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1525"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1582"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1617"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1642"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1667"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1702"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1755"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="12">
        <location>
            <begin position="1365"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG82720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1809" mass="194712" checksum="902BB6E8C5F3E3D8" modified="2014-06-11" version="1">MTTDALSPAKRALLERRLRRRTAPVATIPARPDGEAPQLSFAQERLWFLEQLTPGSGAYTIPVVLRVRGPLDRAALRTALCGVVARHEPLRSRFTDAGDGRPVLTVDPPVAAAALELDLEEVAEEHAQARVEAHVTPPFDLAAGPLVRPLLLRLGAEDHLFVLAIHHVVTDGWSMDLFLDELTAHYDAAVTGVPAELPALPVRYRDYAAWQRARTDGPEKEADLAYWRGAVAGLEPLDLPTDHPRPPRQTFRGAEYTLDLGAPVRTGVTRLADAHGATPYMVLLAGVHALLGRYSGQADFAVGSPVAGRTQAELEKLIGLFVNTLTLRASLGGDPTFAELVRRTRETCLDAFAHQELPFEQLVQALNVPRDVSRSPLFQVLFAVQNYAEHSGRAPVGTVLEHWSAPVVATRFDLEIYVRDDPAGHLWATFVYNTDLFRPDTVERLAGHLRRLLEAGLHDPDRPVGDIALTTPDERVARTGPPVEVAPDATLPSLIAESVRRRPAAVAVTFSGQDLTYAELDARSAALADRLRGLGIGPGHLVAICAERSLELVVALYAVLRVGAAYVPLDPEYPVRRLEFMLADSGASIVLTQRRFASLLPSQRQIHLDDATDDDVRPDVVGGGPEPGPRPTDPAYVIYTSGSTGRPKGVPNTHRGIVNRLDWMQRTYRLGDDDVVLQKTPASFDVSVWEFFWPLLAGARLVLAEPGGHKDAEYLRDLVRTEGVTTLHFVPSMLAMFLDADGVTGCASLRRVICSGEELPVDLARRCLALLPAELHNLYGPTEAAIDVTAWHCGADALEGLPRVPIGAPIQNLTLYVLDDRLRPVPVGLPGQLYLAGVGLATGYLNRPALTAERFGPDPFGPPGSRMYATGDLARWRPDGTVDFLGRIDSQVKLRGLRIEPGEIEAELRRQPGVREAAVVVREDHPGDKRLVAYLVAPGGVDDAALRTALRGALPDHFVPAAYVELPALPLTPSGKLDRRALPAPVVRRDASTALVEPRTDTERLIAGLWSELLGVDTLGIDDDFFDLGGHSLIATQVAARLRRVAAGGVSVLDLFAYRTIRELAAFVEQPARARGPRRLLNELTRPVPADQRVATLVCVPYGGGSAVVYQPLADALPAGWSLYSVAIPGQDIGLREDPLPFDELAARCVTEVIERIEGPVVIYGHCGVGSSLAVETARRLEAAGRAVEAVYIGAVFPFARPTGRVSSLLSTIAGRERLLGNRVYENWLRSMGVDMAELDPAESDVIVANMRKASEIAEEYFTGLFAGGAAPLRAPIVSVVGNRDPQTEFYQERYREWHLLGPSASLVVLDEGGHFFLKYRAAELAEIVTTVHRTDEPLRDPEGGWSVTGRSTSGVAPRRTSGPEPSLRRFGTVAAAQLVSIVGSALSEFAIPLWIYTQTGSLVKFATFAVLGLVPGMLVAPFAGAVVDRYDRRRVMLIADAAAGGSQAVLLGLALTGRLGIGAIYVLLVTLSVALTFQRLAFASAVPQLVPKRYLGHANGVVQMSFGAGQFLVPLVAAGLLATIGLPGILLADVLSYGVGIAVLLFVRFPNTMAWVRRETFWQEVVGGWRYSLGAAGLRPVLLFFAVLNLFMTPLFLLLSPLVLSFSDLDAVARTSMAGGLGAVLGGLLMSVWGGPRHDRVRGMLLVVLGLALCSAVPGLRPSEWLVAVGAFGMSFGLTLANGVYTTVVQVKVPQRYHGRVFAVNTVIAFSTIPIGYAVVAPLGSALLEPLMAPDGALAGSVGALIGVGEGRGIALLFLLLAAAMVVQVLISLRRPSLARFDDRVPDAMPDDLIGAKALAEKKKERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRS5</accession>
    <name>A0A010YRS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852988.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4097"/>
    <dbReference type="HOGENOM" id="CLU_069356_13_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="21340" checksum="B134C7770E3782B6" modified="2014-06-11" version="1">MAVRAGVYRGVSAADRVAERRTRLLAAGLTIWADPGVRTTMTAVCAEAGLSERYFYESFTGLDALLEAVMNDIAAEIETTSRRAAEAAEGGPAERVHAAVRAFVELLLDDPRKGRVAIVESVAVPKLRQRRTELLRYLAHQSAIEAQRLLGARVDEVAGLLFIGGMAELVTAWLDGTVDATADEIVAAASRALLGLYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW67</accession>
    <name>A0A010YW67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">CryarDRAFT_0423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847989.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.407"/>
    <dbReference type="HOGENOM" id="CLU_047148_0_2_11"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="30796" checksum="86F1E3F02449743E" modified="2014-06-11" version="1">MSAVRVPIVVHDREALARERERADGPVAVVMTMGALHEGHAALLRQARARAATVITTIFVNPLQFGPNEDFDRYPRTLATDLELCAREDVDVVFAPSAAVMYPDGQPRTRVNPGPLGEILEGASRPGFFHGVLTVVLKLINLTRPDVVFFGEKDYQQVALVRQMVRDLDLDIEVVGVPTVREPDGLALSSRNRYLSGPERTTALALAAALRAGAAAGEGGAAAVEAAANAVLGDASGLQLDYAVVTAPDLGPAPESGEARLILAAKVGTTRLIDNGPVRLASRTGLPPFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWC7</accession>
    <name>A0A010YWC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569627.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198178_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="25172" checksum="EED01A5DEDA10E78" modified="2014-06-11" version="1">MSNAFSNEDVAAAAEVLAESIRRHAAVMVDADAPVRDALAAIEGLRTSARRYEEVIFGTSGWGPVFADLDEDDFDEDDDDEHDHPQEELVTTGAPPMTVTVRARYDYQIADPDALIQAGQLARIRSWDGDPHGAEPVAGVGEAIYELFHLAGSTFPALEVPELEPGSGFMTVHHTAAPLQPDDVVGAGVDLEELLISEEEDELLYDLAEPRYATREEAEEASRRLEQDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWF1</accession>
    <name>A0A010YWF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848167.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134850_0_0_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="17008" checksum="5DE2632BA6C16224" modified="2014-06-11" version="1">MANWEQFSAEAPDLAERIKARFTATKHHVLATLRADGSPRVSGTEVDFYGPDLTFGSMWEARKALDLRRDGRLALHANPGDGTMDGGDAKVSGVASEVADQKAYLAERKPPEPYHLFRVDLLDATLTSVDHERNVLVVELWRPGRPVQRTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXK4</accession>
    <name>A0A010YXK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">CryarDRAFT_0976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848694.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.959"/>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_11"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="34982" checksum="2E0C475924BB5F95" modified="2014-06-11" version="1">MAIHAKSRKSLVLLTGRAAPELAAEIAVDLETHVTPTRALEFASGELFVRFEESVRGSDAFIIQSVCAPVNQHLMELLLMLDAAKRGSAKRVTVVLPCYPYSRQDKKHQGREPISARLVADLLKTAGADRILTVDLHTAQIQGFFDGPVDHLFALDLLANYVKEKYAGRELTVVAPDSGRVRVAERWTDVLGGTPLAFIHKTRDPLVPNQVVMNRVVGEVKGRTCILVDDMIDTGGTIAKAADALKEEGAADVVVAATHGVLSDPATERLKNGPISEVILTNTLPIGPEKELDKLTVLSIAPLIARAIREVFDDGSVTSLFGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZP0</accession>
    <name>A0A010YZP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849663.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2022872_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="12815" checksum="85CA92AF2B72EC8A" modified="2014-06-11" version="1">MNDQSALAAALMYKRRDHKPTYVLWAAALVGLQAMVFALSALLHVTERDSATAATLGLGVVGAALIAAGLLRGNRVAYVMAAAYALVGAVLAAVFDHRPSVAAIAVLILLGTTGSREYFFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z074</accession>
    <name>A0A010Z074_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type uncharacterized transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849965.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1912"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="34861" checksum="EEF2CDDE57FAE888" modified="2014-06-11" version="1">MSVVVVDGLRKDFTVWAKKGRLRRERRSVPAVDGVDLRIEPGEMVGYLGPNGAGKSTTLKMFTGILTPSSGTVRVCGLDPVPERARLARRIGAVFGQRSQLWWDLPLAESFTLLRSVYRVAPTDHAKRLAECRELLDLDEFLATPVRQLSLGQRMRGELTAALLHDPELLFLDEPTIGLDVVSKEAVRGFLAELNQRYGTTLVLTTHDLADIERLCGRLVVVDHGRIVHDGTLAALHERYGSRRRLVVELDEPHQPLDVPGATTESVEADGRRQTLALDGPLPAVVAAVAAAAPLRDLRVLEPAIEEVVTRLFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3R2</accession>
    <name>A0A010Z3R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796236_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="348" mass="37393" checksum="3A09F5AE3D312D70" modified="2014-06-11" version="1">MVRPKHRSNAPPRETIARESRGFLSLASAPEQTGRTPHPSTLSIGARMAAPEPPAPETPNSVSRREGHPQRGTVLPAADRGSGEFPREFSREFVGLQLRGPTSTPTLRVTAHRGRGLTPGRRVVKSVRPGDNSDENGGAAAPPELPRGCRSSVQPAARLALCKAAAEVAAHTSSRPYAASVDVGDVIAGISGAAAIGSLAVAFTSNRAARDAASIAQAALYDARTPRFTVFVEEVEYERTDYLHVRLDSARKLDGYTLTILRREGLRLVPRSTKPNCALAVSDIGGEVPGPVRVGDERIWHVAVDEHGWTGSTRIRLTCLVGDEEWDVAYVVSFPRPDRYEPSRIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3X0</accession>
    <name>A0A010Z3X0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3183"/>
    <dbReference type="HOGENOM" id="CLU_012904_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="267"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="862" mass="89802" checksum="4B8A8488EF11A308" modified="2014-06-11" version="1">MRSVESTSTSTLLGGATGTGLTAEGLTKTFGSTTALNDMSATFARGVVHGLIGENGSGKSTFVKLVAGMHRADAGRVVLDGVPVADTSGTHRSAARIACVYQDGSLIDELTVAQNLDVIVEPALRPSAPDGSWHRQVLDAARLTDVEENTRAGDLPNNEKRLVEIAAVLARRPDVVLFDESTSTLDERGVEWVLARMRELADGGACVVFVTHRLHEVLAITSHVTVLRDGVLVAEVPTEGATTEQLVRHMAGREVAAFTRRTGAAPADAEVALRAAGLRAARCGPIDLTVRRGEIVGIGGAAGNGQAELIRALAGDGVDAGEVIVDGAPLRGAGSAVDAGTVFVSSDRRSESLSSLLSIRENYTLALTATSGRWWRWLRRRPEVAEADALADRYDLARSSIEQPVGTLSGGNQQKVAIGRMVARDPKVLLIEEPTEGVDVRARFDIYRSLVEVADRGTAVVFTSSDAGELRLLADRVLVLARGRQVAELSGDEVTEEAIVHAFTTAKEQQDARSAAAVADEARELDEKPEVVARRRAGLRPRRQLTFTPATFGLLAVLLVALAAYGTARDARFGTIDNLGSIMQLSVPLALAALAQLPVLLVGEIDASIGSMMGLIVVLLSFRPDGSPAVLFVLAVLAGAVLGAVNALLVVGLRITAVIATIATLGVYLGVARILRPEPGGLINNDLAVLMGQGVAYIPLMFLVVVVLAIAVDVYVNTTRGGLRSRAVGYSALRASQLGVPSSRLRAAAYVLGGAIAGLGAVTLAAQTGVGDPSSGSGYTLLSIAVPVIGGALLAGGRGSAIGCVLGALFVAEVQTFIPFVNFPTGGYLIAVGVLTVLALIVGSARLSAWTLPIRNIRRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z447</accession>
    <name>A0A010Z447_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851762.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3259"/>
    <dbReference type="HOGENOM" id="CLU_051674_1_1_11"/>
    <dbReference type="OrthoDB" id="1828250at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="25906" checksum="11730A98313682B0" modified="2014-06-11" version="1">MNRALQSEWVKFRSLRSSWLTLACLFFVGLGITALSAGNAAAAYADAGASWDPTAHSLTAYIVAQLIVGVLGTLIVTSEYATGLIRSTLAVTPRRHRVLGAKVVIAVLVAVVAGQVLMFAAFLIGQPLIAGQDVPEAGLGDPGVLRAVLAGGVYLALIALLAVGLGAIMRATAGALTALVGIVFLVPALAGIFPTWMQDLFAIWPTLGGAAALSTVADPDFPHPWWNLAGMGAAIVGVLAVAFLVVRRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z497</accession>
    <name>A0A010Z497_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851869.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3324"/>
    <dbReference type="HOGENOM" id="CLU_079903_0_0_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="28115" checksum="C435F84288C54DC8" modified="2014-06-11" version="1">MAWSTRELAELAGTTVNTIRHYHRLGLLEEPERRYNGYKQYGVEHLICLLRIRRLVELGVPLAQIGEVRTNGAIAPDVLRQVDAELAAEAERLRRARSDIATILSTGASADTPSGFESVASRLSEADKSLIHVHTRLYDEDAMKDLQRMAEADEDPTNGEFDALSPEADDATRQRLAERIAPVLVRHLADYPWLSDATGRTSMDERATRETFIDAVANLYNPAQLDVMGRAGVLAQEQLRAARETPPDDVTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4Z9</accession>
    <name>A0A010Z4Z9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">CryarDRAFT_3607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852219.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3567"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_11"/>
    <dbReference type="OrthoDB" id="577156at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="7"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="420"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="425"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="425"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="509"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG82423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="748" mass="80647" checksum="9ACB751EA817F296" modified="2014-06-11" version="1">MSNFGRSTVLGYPRIGPHRELKKAVEGYWAGRITEADLHALAAELRADVWRTLREAGLEAIPSNTFSYYDHVLDTAVAVGAVPERFRRLGLSDLDTYFAMARGVDAEPALELTKWFATNYHYLVPEIGPDTVFAADPAKALAELAEAPGTRPVLIGPATFLLLAKAADGAPEGFRPFDRLDDLVEVHAQILGALADAGAEWVQLDEPAYDADRTPAEIDALRAAYARLVALEHRPKIFVATYFGALDDALPALLETRVDALGLDLVNGARDLDRLAGTGTVSGTTIVAGLVDGHNVWRADLGAAAARYATLSGLAEDVAVSTSCSLLHVPVDLAAETDLDPALVERLAFARQKVDEIVALSKVLDDGVGGLPASPGEAPEAWRDQTVRARLDALRPEHSRRGAYADRAAAQQQRLNLPPLATTTIGSFPQTDALRHARAEVRAGRLDAAGYEERMRAEIADVVARQERLGLDVLVHGEPERNDMVQYFGEQLGGFAATVGGWVQSYGSRCVRPPIIHGDVTRRAPMTVAWSAYAQSLTSKPVKGMLTGPVTILAWSFVRIDQPLADTANQVALALRDECHDLEAAGIRIIQVDEPALRETLPLRRADQKAYLDWSVGSFRLATSGVADSTQIHTHLCYSEFGEVLPAIDALDADVTSIEASRSKMEILDDLAAAGYSRGVGPGVWDIHSPRVPARDEVTDALRRAVAVVPAQRLWVNPDCGLKTRGYAEVEASLAHLVAAAAEVRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z562</accession>
    <name>A0A010Z562_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852313.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3641"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_11"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="2"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="345" mass="35176" checksum="57A3CA1B3755EA2C" modified="2014-06-11" version="1">MRALRLVAWHHDPEFAELPVPDPGPGQVLVRVGGAGVCHSDLHLLHDFPPGLLDWPVPFTLGHENAGWVHAVGAGVDLEPGLPVAVYGPWGCGTCRTCATGAENYCASVPGNWTVAGLGADGGMAEYLLVPSARFLVPLPDGLSPAEAAPLTDAALTPYHAIAKARSVLTPGATAVVIGIGGLGHLAVQILRATTDSEIIAVDTKPEALELAKTCGADHLVHASACAEDAVRNLTRGAGAAAVLDLVGSDATLSIAARSVAKGGQILIVGLGGGVLPVSLLGTPYGVSVTPTYWGTRPELHEVLRLAARGDLRAEVRTWPLSRATDAYAAVAAGTVPGRAVVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5T2</accession>
    <name>A0A010Z5T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852631.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117589_0_0_11"/>
    <dbReference type="OrthoDB" id="1941817at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="17158" checksum="99098DA747BA12FA" modified="2014-06-11" version="1">MHEAGLGDGATAVYVLIGACGAGLLLLGLVGAGLLGLVSTGVGGASGPTVAAFVGMFGFAAAGASLLLDARGPGAVAAAGAIGVAAAGPTAALVIRASRWARDIPTDPTPGRADLVGAIGVVVTPIAPPGYGEVRVRVGGQPVKLHARADEALPLGADVFVVEATSHASVVVEPLLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z670</accession>
    <name>A0A010Z670_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0303 protein CryarDRAFT_3989</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0303 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852732.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3962"/>
    <dbReference type="HOGENOM" id="CLU_101036_2_1_11"/>
    <dbReference type="OrthoDB" id="1742795at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16590" checksum="3F2686D3E02C30EF" modified="2014-06-11" version="1">MSDEALETLLAQEDRLVFPRFDEQTAWELGGALRAAALAERLPVAIAIRRGAALLFHTALPGASADNDGWLRRKAAVVERYGHSSYYVGCRFRAEGGDFDVDSRLDTGEYAAHGGAFPLIVAGSGAIGSVGVSGLPQVEDHRFVVTQLERFLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK00</accession>
    <name>A0A010ZK00_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="16" type="ORF">CryarDRAFT_0001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051571850.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1"/>
    <dbReference type="HOGENOM" id="CLU_026910_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="14">
        <location>
            <begin position="387"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="15">
        <location>
            <begin position="599"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EXG78989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="696" mass="76493" checksum="62747EEAD96ED891" modified="2014-06-11" version="1">MTDESVDLEGIWTAATESLADQDLSPQQRAWLRLTRPLALVEDTALLAAPNQFAKDAFESRLRGVITDAISRQLGRTVNVAVTVRVPVESQTMELHVLDLPPVDNYRPDSYPPGRYEPDRGVEYGGARGELEFPTQSGGSYRPESFRPYGESAPPSVPVSPAPTTYGSATERYRPRPDDHDRPDARRPDPYLPDQHGRNDPHVRNEELGHAEEIAPPDASIPGAADSADPLAPSERGRGRHAAGSSEVEVPHPSAPPVGTGTTGSASVVGTAGIPGYAPPSFPEQPSYRAPGPYGGARPGGFEPYDGGNYPQNFDNRGRHHTPPFGTDAPNGGESSTNRGIRRGETPRPTEPARLNPKYTFDTFVIGSSNRFAHAAAVAVAEAPAKAYNPLFVYGGSGLGKTHLLHAIGHYAQSLGNARAVRYVSTEEFTNDFINSLRDDKTQAFQRRYRDVDILLVDDIQFLESRERTQEEFFHTFNTLHNANKQIVISSDRSPKELSTLEERLRTRFTWGLLTDIQPPDLETRIAILRKKAAMERLAAPPEVLEFIASKIQSNIRELEGALIRVTAFASLNRQPVDLGLAEIVLKDLIPEGGGPEITAATIMAATAEYFSVSMDDLCGSSRSRVLVNARQVAMYLCRELTDLSLPRIGQAFGGRDHTTVMHADRKIRQMMAERRSLYNQIAELTNRIKQRAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKW6</accession>
    <name>A0A010ZKW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847786.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905259_0_0_11"/>
    <dbReference type="OrthoDB" id="552895at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="32737" checksum="D5088EC85CAF51EE" modified="2014-06-11" version="1">MAALAALVIALTAVRFRGRWAYEWLGLVTRYSLRRRRWQRTNAPEPLILTAVAPGARIGQIDLPDHPSRTAGVVTHEGGLTAVLEIRPEVDAPVPLPSLLALLPMAEVGEPPITAQTVVETVPLPDASIPARRHGWVALQAVRTNERAGPDVDELRAALTGAIRRTQRRLGKSGFATHVLEPDELAGTIDELGYDPDAIGEEWAHWLTPACASVTLSVAGGNDLSMIDRLPEVAGVPTVLALGIRRAGGGVEVEASIRLVAADRSEVDRATQAVIAAATALGLRLRRMDGEHVRGVASTLPLGAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKX2</accession>
    <name>A0A010ZKX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569583.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2011431_0_0_11"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="12724" checksum="FDCE6B069EB9AD97" modified="2014-06-11" version="1">MTDGSTFLRPKQAARAAIQLASIADDLKAKLDASVARIKAIQAKGTQVWGDDEPGTQFVKNYNKGGDGAASATLDAATRYADVFTDVGPIVTRAIDGTVDVDMAVGEAISKLTGQLGNPPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLQ0</accession>
    <name>A0A010ZLQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725649.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.616"/>
    <dbReference type="HOGENOM" id="CLU_111599_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="25463" checksum="A934328F798B753D" modified="2014-06-11" version="1">MNDLVWYVAYGSNMHADRLGYYLAGGRPPGAARTYPGCRDPRPPRRTEPVFLDGGIYFALESRTWTGGMAFYDPGLPGRAAGRGYLLGAGQFADIAAQEMARRPDVDLDLTEAITTGRATLGPGRYETLVCPGALDGHPMLTFTAPWACADAQLNPPAPRYLGMIASGLHEAHGWDAETLTAYLAERPGVRGHWTPDALADRVARIEFRWAHTSGGGTTSPDDAEPNSSCHREMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM90</accession>
    <name>A0A010ZM90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848526.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.787"/>
    <dbReference type="HOGENOM" id="CLU_069356_43_2_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_33" evidence="5">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="19786" checksum="86F43CC6E41E4764" modified="2014-06-11" version="1">MPRAGLTPAVVVAEAARLADEVGLDKLTLAVVAQRLGVALPSLYKHVKGLDALRGHIAALAAGELADALSEAAVGRSGPDALLAMADAYREYALTHPGRYPATTRAPQPDDAAHARAAERALTTIYAVLSGYGLTGDDAVDATRTLRSSLHGFVSLESGGGFGMPHDVDRSFRRLISTLDTAFRSWPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMC3</accession>
    <name>A0A010ZMC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848576.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1764969_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457994" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15700" checksum="3730D2F299654C5F" modified="2014-06-11" version="1">MFRITALALVGAAVLAGCGSAPEAPGAAQALVAGDAQVATLEGNVWQPVDLTGCSVPWGLAVMVEESGISRREFTFTTHGSIQVRQVEVPDDPDTGDAYALAYSREGSTLRVRAGLGIEAWTIRELTSVRLLLEDENGDECWLRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNQ7</accession>
    <name>A0A010ZNQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849134.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1352"/>
    <dbReference type="HOGENOM" id="CLU_1222965_0_0_11"/>
    <dbReference type="OrthoDB" id="1818136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="23414" checksum="81FA3B9202795895" modified="2014-06-11" version="1">MTTTYTATPTREQNKSATRTWAAIGVAAGVTGVASIQTSLTIDAGYAPDTIGDPEKVVERLADQTVAILVTHTLTIVTALLLVVFAAGLKRRLEAQAPVGSLLPSVAASGLGLVSVAGLLGSGLTTEFVFGANAPKGELVAESGDFYAHWIATIPWLWVGAGLAGVAVAAAALKHSAAPRWIGWVGVVLGGLTLVAGISPLQYMAGFTGPVWLLVTALGFLFADRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNT8</accession>
    <name>A0A010ZNT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861100.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1390"/>
    <dbReference type="HOGENOM" id="CLU_091396_4_0_11"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16680" checksum="0952B698217D9369" modified="2014-06-11" version="1">MRVYVGSDHAGFELKQHLVEHLTKAGHDVVDVGPHQYDAEDDYPPFCLDAARKVVADPGSLGVVIGGSGNGEQIAANKVPGVRAALAWNIETAQLTRQHNDANVVGIGARMHSAEDATTIVDAFLATEFSGEARHARRIEILAEFERTGEYPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP71</accession>
    <name>A0A010ZP71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CryarDRAFT_0042</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847396.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.40"/>
    <dbReference type="HOGENOM" id="CLU_038423_1_2_11"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="17">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="16">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EXG79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="30551" checksum="78E2C5E66C6A1C4F" modified="2014-06-11" version="1">MPELPEVEALAAYLRERAVGHAITRIDVAAIGVLKTYDPTPLSLHGALITGATRHGKFLDLDVGGIHLVAHLARAGWLHYRDKLPAAPPKPGRGPIALRVHLDDESGFDLTEAGTKKSLAVYLVRDPNEVPGVARLGPDALAVSEAEFTERVRSHRGQIKGVLTDQTVIAGVGNAYSDEILHVAKLSPFAIASRLNDEEIARLYGALRSVESDAVERSIGQGSATLKAEKRSGLRVHARTGLPCPVCGDLVREVSFADRSLQYCPTCQTGGKPLADRRMSKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP90</accession>
    <name>A0A010ZP90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068804_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF" evidence="1">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="27248" checksum="EB6A854F75965115" modified="2014-06-11" version="1">MTTSRGCVDAGVLSDPRALRDWITRYGEYHGSVRFPVASALAFKAYTWALIEAAVGRWVTERRVVDVSMSRVRIRTEAADEPQLEFVALHHTVLPDDPMAGQPGVAVVATEDELLEVLRRTLVDNHLEPAVEAFRALRGGGPRPLWGTVAQSIGYPAATADPTFLPDRAATVQRLLSILPDGVAQLVEIAELDEGQGWRPLLLRRTCCYAYTLPAYGQPCLTCCLLDDAGRDAVAAEDQVSWRRCTSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPI1</accession>
    <name>A0A010ZPI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632694_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="433" mass="45838" checksum="7839C30B0875E260" modified="2014-06-11" version="1">MKRTKGRRNGRPPRSDEAPPPEPTEPEPRLLWGVDADAVGTLCSMRLEISSALLRRSADRFTGHDAVADTALVHRLTSITPEVGLELPADRIGNAAELVAHATDADVRIGAVLPDVSARPGRPFPLCHPDADLSARALAALHRAAGVALDVRARRLVIRLHDTAPYPGRAEAQRRLDQLADVVTGLRRQLPPDLAVVVDYAITDPQPVRRGRPDWQTALTLATAAGPGTKVLLDPAPLVDEDPELSITTLRAGDRLAGVLLGRLVTIDRPFALFLAMIDAAEGGVLVRGRRCPVPFVVALPPGRAPGIEAALRAVGAVQEAAAKAMLLDRSAWRAARAAGDARAATDLLLTAYETDATPLLTAVRAALGVPADAIASYRELCRDTHRAVERQRSLLRAALRQAETSVGLVGAGRIVPAGGGGRAGRWALRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPI7</accession>
    <name>A0A010ZPI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tRNA adenosine deaminase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125819_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17480" checksum="032E4A9762B8E194" modified="2014-06-11" version="1">MDVSYFAAALARPRQGWVATELDLDEIEVADDAADLLREVDPDAPLALMFVEADDEFLVVFRLDNGDEMRIFASDASFAEESRVGAVLLEELDEIDVASSDDSDEPELVGVPVGEADLLADLGVSARDLLALCAHEGMLPSDVMLAISRKIGGAEALTNLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPK6</accession>
    <name>A0A010ZPK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">CryarDRAFT_0182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847633.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.174"/>
    <dbReference type="HOGENOM" id="CLU_118482_8_0_11"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15999" checksum="2A99C259AE5772F7" modified="2014-06-11" version="1">MNYLLDTNVIAELTTRPRPSPAVVAWARSVPAPSLYVSVVTLAEIELGIAAVLDLDRRAIFERALVGIRHEYKDRIAEIGEAEALAYLTIHKRLKSAGTPIDPPDALIAATALARGWTLVSRNVKHLARTGALVMNPWDHDITGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPL0</accession>
    <name>A0A010ZPL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849586.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1674"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="391" mass="41054" checksum="21F2D3C881C5E202" modified="2014-06-11" version="1">MTNTRVLISGASIAGPALAYWLHRYGFDVTVVEKAPQVRACGQAVDFKGPIHLGILRKMGILDAVRRAAVPSEDGILVNARGRKVGSVPGAFAGGEINVPRGDLANILYGLTAETCEYVFGDSVTALADTGDGVDVSFAHGAPRTFDLVVGADGIHSNVRALAFGPESDYVRHLGYYYALADLDVDGNEVMYNEPGIMAALGGPKASAFFVFAAPLSPAGRGDADAQKQFLADALRGGRWRIPELLAELPHAREFYLDSISRVTVDRYSAGRVVLVGDAAYGNALGGFGTGLAVVGAYVLAGELARAGGDHVAAFARYESTYRDYASVSQKINAGRLLAPGTKPGIVARNLGFSALSLFGPLMKIVDRPATNLTLEDYPAQHAPGTSEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ89</accession>
    <name>A0A010ZQ89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849924.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1887"/>
    <dbReference type="HOGENOM" id="CLU_018398_4_2_11"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="27330" checksum="3C8036239AB024E7" modified="2014-06-11" version="1">MSGPSSPLSERAIAGRLRAAGCVFAEDEAQLLIAASPSPAELLTMVDRRVAGLPLEHVLGWAEFCGLRIAVDPGVFVPRHRTELLVRQAARLAPPAPTVVDLCCGSGALGAALAIRLPDVDLHAVDIDPAAVRSARRNVRGRVYQGDLFAPLPTTLRGRVDVVLANAPYVPTEAIRLLPPEARIHEPQVALDGGADGLDVLRRVVAGAPGWLAPCGHLLMETSGHQAEALASCGAAAGLECRVVSSDEVTIVVAETPKAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQC8</accession>
    <name>A0A010ZQC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.431"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="34017" checksum="4C4F83509CE63BA3" modified="2014-06-11" version="1">MPAHTRTRPPVQAPAADPPPRAPKKPRRNQLWFFLVPAIALYAFVVLIPSGRGALLAFTDWDGLSPERAWIGFDNFTAILDDADARAAVGQTLLVAVAITIIQNAVGLLLALGVNSRIKSRNVLRVFLFAPAVMTPVVVGALWKNLLAPDGAVNWALDTVGLSGLKQDWLGDPNVAIWSVVGVVVWQFAGYSMVIFLAGLQGIPQDIHEAAEVDGAGPVRRFRHVIFPLLAPATTINLMLSIIGGLKLFDQVWVMTGGGPGHSSETLSTLIYKDAFQFGEFAYSIALAVILTIFVAIISSGQYWLLRRQEESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQI9</accession>
    <name>A0A010ZQI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674985_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="157" mass="16687" checksum="BA1E7BF313CF9277" modified="2014-06-11" version="1">MSKGLHRAGRRRKRPGSRRLGGRAAIVAGAVVLAMIVIGLPLAAAPRTATGSTTDGAAADCVVASVGENLVRIICGITDLSRDGDSVYIGWRTTSGGVRSIYHREGAGHTISVTGYAPTAAGEPPHRVLWRVCRDRQAPWRDTCSEWRTVWATPTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR68</accession>
    <name>A0A010ZR68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848470.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.733"/>
    <dbReference type="HOGENOM" id="CLU_016047_14_1_11"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="51"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="27620" checksum="B1E80C8138DFCDA6" modified="2014-06-11" version="1">MSRRTGAPAPLAVPALIAVVFLALPLLGLLVRAPWATLPHLLSDPLVAEALRLSVISALLATALSLVFGVPLAWVLARAEFPGKALLRALVTVPLVLPPVVGGVALLLAFGRRGIVGRYLDQWFDYTIPFTTTAVVLAETFVAMPFLILTVEGALRAADRRFEEASASLGAGRLTTFRRITLPLVAPSVLAGAVLCWARALGEFGATITFAGNYPGTTQTMPLAVYLALESDPDAAIALSLVLLVVSILILVALRDRVVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRH3</accession>
    <name>A0A010ZRH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15932" checksum="B0B05E9B96AEEC9A" modified="2014-06-11" version="1">MALLRAEDLVVGLEIDLGSYTVTADEIVEFARQWDPQSFHVDPSAAAESYFGEVIASGLHTLGVLQRLAVLGAYQHWDVIAGRRIRSIELTAPVTDGSTLTGSLVVEEVTPRGPERALVAVRGRLVGSDRRPVLDAVFEMYLRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRQ5</accession>
    <name>A0A010ZRQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2914762_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="61" mass="6493" checksum="0678D26520576F5E" modified="2014-06-11" version="1">MSIERRLPSKVAGEPLEPGKVRAKIVGLETFRETGSLQATTSPAPEPPPDMGNAESANYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRX9</accession>
    <name>A0A010ZRX9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848735.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1009"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_11"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="37217" checksum="F23AB0526AE8A2C3" modified="2014-06-11" version="1">MTVLVTGGAGFIGSHTCVELLEHGHEVIVVDDFSNSAPAALTRVEEAAGRPVGALYEGDLRDESLLEWVFRHHEIDAVIHFAAKKAVGESVDIPLEYYDINVSATTALLRTMLTHGVGRLVFSSSCSIYGQTETVPLGEAEPAAPTNPYARSKWFCENIIADACRRYPQLDAVALRYFNPVGAHSSGLLGEDPTGVPNNVMPYMMQVAIGRRPELQVFGADYATEDGTCVRDYIHVMDVADGHRVALEKLGAGFEVFNLGTGVGTSVLGLVRAFEDACGVSIPHRIVERRSGDVPRLIADPSKVAGAWGWRTTRDLHAMVRDAWEFQRLNPYGYETLALESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSJ2</accession>
    <name>A0A010ZSJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29828" checksum="E2ED3727DEFBCE2F" modified="2014-06-11" version="1">MTLRADDLTLAYGRHVVVDRLTVEVPPGRITVIVGANACGKSTLLAALARLLAPKHGAVTLDGRSIHSQPTRQVARSIGLLPQSPVAPGGITVVDLVTRGRSPHQNWWRQWSEEDEQAVERALAATGMAEHRNRPVDELSGGQRQRAWIAMAIAQDTPLLLLDEPTTFLDLAHQIDVLDTVVDLNRTEGRTVVMVLHDLNQACRYADHLIAMRDGAIVREGPPGAVVDAELIRTVFAVECQVSADPVTGTPMIVPMGRHHRVEAPKEESAAGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTL0</accession>
    <name>A0A010ZTL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3126"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26705" checksum="C7DF70F748F2F637" modified="2014-06-11" version="1">MQIAVVTGASSGIGQSAAIQIASRGTGVILTYHGNENGARETVSTISDAGGTAVALPLNVGESETFAAFRDSVAEAARVVWQRDRIDFLVNNAGFGRMALFEDTTEEMFDSLMRVLLKGPYFLTQTLLPLMTDGGAIINTTSNAARSSGLEAGYSAYGSMKGGLMVLTRYLAKELSARGIRVNSVSPGATRTRIADDSFERFPEVIPPIVARTALGRLGEPDDIGMVVAMLLGEECRWITAQDIEVSGGFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTT8</accession>
    <name>A0A010ZTT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851705.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3218"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="33969" checksum="C96CA42EE4771BD8" modified="2014-06-11" version="1">MAQVLVTGGSGFVGAHTIVRLLDAGHEVRTTVRSLRRAGEVRAMVARPGAALTFAEADLTVDDGWVAAVEGCEYVLHVASPFPAGEPSDPEEIIAPARDGAVRVLRAASAAGVRRTVLTSSFAAIGYGDALDRPYDESDWTDPAGDLPAYIRSKTIAERAAWDYAASVGAELAVINPTGIFGPVLGPDYSTSIGLVRAMLDGRMPTVPKASFGIVDVRDVADAHIRAMTTPDAAGKRFLCTSAAADDPFAGAQGSYLEIARILRRRFPALADRFPTEEATGPEVPAKAYRIERIRTVLGWDPRSAEGAVVATAESLVPLADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU13</accession>
    <name>A0A010ZU13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570362.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107911_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="24197" checksum="00E603D7E209C489" modified="2014-06-11" version="1">MPYRSSIREERARHTRREVLAAARVSFIDRGYAGTTMRMIAAGAGVSVPTVELLFGTKAAVLKATIDVAIAGDDEQIPVLDREWSVRARAAGDVPGLLTVVVGVLGAAQERSAGLVLAALEASITDRDLGVVSEQLVAQRAVTAGWIADQVAARSPLRTGLTRADAVDTVWLLMDPAVFVRLTRHRDWSMPRYQDWMARSLRTLLVPDDLPTEPPTTSMPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU16</accession>
    <name>A0A010ZU16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725682.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132543_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="172" mass="17841" checksum="BC4C5AE00698D168" modified="2014-06-11" version="1">MVQQSLVRTDTGVSPGAERPPRVVRAATVAWVAAVAAGAVEALGMSVAWALGEVPGLSGGSLAAGLGVRAVVYTVVLLVVARFWRGRNWARLTLAVGLGVVGMLSLVLEPVSWLADGHSLADALSEGGLALALTIAIRALHVAAVLVGLALMFRPEANRYFRDARRGLRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUC4</accession>
    <name>A0A010ZUC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569958.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1850"/>
    <dbReference type="HOGENOM" id="CLU_805899_0_0_11"/>
    <dbReference type="OrthoDB" id="1843936at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="344" mass="37821" checksum="5322FAF62665B88D" modified="2014-06-11" version="1">MTDPFADLENEVALDRVGTRGALLDRALRGYVPLRKEFVQLHDKADDGTRGSVLGQLLADRQERALDALLLLHALWPAIDGDAEPLPMSQWALMLTTDHGGECTPNAASKAFTELEKRGLVRRESVGRGTRITPCREDGSGDDWENPGTNPSDRYFTVPHLYWIDPIVDGSTPADALRLPGKAMLLIALKETQDPGKPGRFSVAAARGEEWYGISERSVERGYGELRKAKLLAERTQRVRNPKASNGIQTICWRAPTQGFSTDDRAKLQAEAVSKARAKITARAKSGPVKPTPEPDAKPKPKPKPTRKGKPNLQRIRPVRRSRRTAPDPGTAAAANHREEEVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUD2</accession>
    <name>A0A010ZUD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-B/F/G subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851965.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3398"/>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="6">
        <location>
            <begin position="204"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="28624" checksum="C1F60FF786D77A52" modified="2014-06-11" version="1">MTTTPAEETADYAVYADVEPLFRRYAGLASDTDERRALRTRLVVIHLPIADHISRRYDRRGVPLEDLTQVARLGLVRAIDRFDPALGFAFLSYAVPTVLGEVRRHFRDAGWYVRPPRRLHDLHLRINTAISDLTARDNRAPNATAIAGYLGASPGDVAEALALTHAYRPISLDAHPGGAPEGELLGVDDPALATVVNHEALRVALARLPERERSIVGMRFFQDLTQSQIAARVGCSQMHVSRLLTQTLGRLRLQLLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUV2</accession>
    <name>A0A010ZUV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852278.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_11"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="114" mass="12773" checksum="60F73FBA3D4E0653" modified="2014-06-11" version="1">MKADAQVLKGHLDVLLLATLDEGPRHGYAIRDELRQRSDGRFDLPTGTIYPALHRLEAAGLITGSWSRAEGRRRRSYQLTAAGQQRLHTERGGWREFAATVTAVLDREPWPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVQ3</accession>
    <name>A0A010ZVQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2344"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="92"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="30767" checksum="D698AF2E52FB634B" modified="2014-06-11" version="1">MPAVADVLARDYDAVVHDPARLASYADSVRVVVTGGHAGVDTALLDALPGLRAIVHFGAGYDGTDVATARERGILVSNTPGVLDDSVADTAVGLMIDVLRRFSASDRYVRAGRWATDGPYPLQRTVSGSRVGIVGLGHIGTAIATRLEAFNCPIAYHNRRAVPDSPYRYEPSLVRLAASVDVLVVAVTGGTGTRGLIGREVLEALGPDGVLVNVARGSVVDEPALVALLTAGKLGGAGLDVFTDEPHVPPELLDRDDVVLLPHVGSATVATRAAMADLTLANLRSFLETGTLVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW29</accession>
    <name>A0A010ZW29_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850732.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2497"/>
    <dbReference type="HOGENOM" id="CLU_639266_0_0_11"/>
    <dbReference type="OrthoDB" id="739613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="283"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="435" mass="46985" checksum="70571CC30ADF9937" modified="2014-06-11" version="1">MIDPAAEAARTTDAILTDLRSGAHRGIVVDSPPGAGKSTLVVRAALELARAGERLMIVAQTNEQVDDLIVRLAAPLFEARPDARIGRLSRGGFVAPPRLAALPNVVVSSALADLNDPLVTIATAAKWAHVRDAVWPWAIVDEAYQMRSDALLVLAARFERALFVGDPGQLDPFSTVENDRWRGLTWDPMQSAISVLLRNNPTVPVHRLPVSWRLPYSAQDVVAKAFYPFTGFRTGTGPGERELGFRTAGHGVEDAVLTTAAKTGWSLVELPRRHTLRTDGEAVEAVATIARRLLERGATARDGSEVTSVGPSRIAVGAAHRDQVAAIRAALNHPEIVVDTANRLQGREYDVTVFLHPLSGRRDATAFHLEAGRLCVLASRHRQACVIVARAGIRDLLDAHPSSAPVHLGDPVKFPDGWAANQTMLAHLEPHTVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW98</accession>
    <name>A0A010ZW98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570094.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2570"/>
    <dbReference type="HOGENOM" id="CLU_048478_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="38024" checksum="9F03153E65DC9BED" modified="2014-06-11" version="1">MLGTEQQAAWGRRELPPVEKLAGGVWSVPVPIPDNPLRYTLSYLLPGDSGVVIVDPGWNDEDTWAALTTGLATAGYRLGDVLGVVATHVHPDHHGLSLRLREETGAWVAMHPAEAASMPQRMGATTSEIRRTGMTRILRMSGTSEEEISGLLGSFNPRFEPDLVMAEPDVLLEDGALVPLAGRRIRTVWTPGHTPGHICLADEETRTLLTGDHVLPRISPNIGLGPSSDAKPLADFLTSLEKVGAYDDHDALPAHEYRFRGLAARTAELIAHHEERCRELIAVVQALGEPTLWSIAQGLTWSRPWEEIGRMRFAALGETAAHVQHLVDRGDLRWVAPDAEGGAPRVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY57</accession>
    <name>A0A010ZY57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thioesterase involved in non-ribosomal peptide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863174.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3247"/>
    <dbReference type="HOGENOM" id="CLU_070456_1_2_11"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="28396" checksum="E11FD0B605A179A3" modified="2014-06-11" version="1">MTISDTATTSWIRRYKPTEGADVRLVCFPHAGGSASYFNSVAARFSPGVDVVALQYPGRQDRRREPVLRDLGELADLVTAELLRLREVPTVFFGHSMGAVLAFECAWRMEEKGLADPQTLLLSGRRAPSALRDEQTYRGDDARLLAELRQLNGTSSALLEDDDILRMALDTLRGDLEAVETYVDSGHRVTVPLVVLTGDDDPKTTVTEAQRWCEHTESTCRVLTYPGGHFYLDRHAAAVGDVVAAELAKVRPTTIGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYP8</accession>
    <name>A0A010ZYP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852022.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3450"/>
    <dbReference type="HOGENOM" id="CLU_170225_1_0_11"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="11721" checksum="79EDB260A10AA8A1" modified="2014-06-11" version="1">MIARTWRGWAPRATADDYQRHYETEVSEHLRDVPGFRGARLLRRTDGADVLFTSIVYFADMAAVRAFAGEDPERAVVEPAARRTLIRWDQRVDHHEVAVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYP9</accession>
    <name>A0A010ZYP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852034.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3456"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="28553" checksum="212F46E0F479AD77" modified="2014-06-11" version="1">MDSLIGKVAVVTGATSGIGVDVARAFVAEGANVVLAGRRRELGEALAGELGPAASFTATDVSDEGAVAALLDLTVERHGRLDVLVNNAGSPSQLGSIEDVDAAAFRAAHEVNLMGALYGIKHATGHLRRQGSGGSIINMASITGTRAVYAGVAYSTSKAALISLSQWAAAELGSYGIRVNCISPGFVTTGRFGKAAGVAEETAQARLSALEAYAREQARSLQALPRPGFGPDVAGAAVYLAGDASAYVTGHDLVVDGGLSLGQPLEAMVRLRDAMAAIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZS4</accession>
    <name>A0A010ZZS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3182684_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="46" mass="4978" checksum="E182B51EFDD3575F" modified="2014-06-11" version="1">MVEPPSSRLPQRSQRIASDPDEARAVLTEAFGARLRVGGVAGRDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZT5</accession>
    <name>A0A010ZZT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852669.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3908"/>
    <dbReference type="HOGENOM" id="CLU_825671_0_0_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458310" evidence="1">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="44"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="34992" checksum="FF6DCD714EE3E15B" modified="2014-06-11" version="1">MPHRPWRRVAVTLGLTGALLASGGCAASPQSTSGTSGGPKGKTVSFVGYGSTNQWGAYFNGVFTEKLDAEGVKVKDLTTMDPGTAVQNFNQAIAEKPDLIVTALLDTTSMAVPIQKAKQAGVPVLVFDGRPDPKVDGDVMQVVSDNVALGTAAAQNIVEGLTAQGKKSGKVFVITGTASSLVTQDRMKGFEAEMASAPQFQVVDVQDGNWDPARSGQIATQLLAKYGCSGIQAAYGMADYMALPIIASAKQAGCPVAGRNGLVVTSSNCFKAGIDAIRAGTLYGTATEDPGTIAAQTADYVLRYFNGENPPKKETVREERVTAKNVEKFAAQCSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZY6</accession>
    <name>A0A010ZZY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852703.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3939"/>
    <dbReference type="HOGENOM" id="CLU_047003_2_0_11"/>
    <dbReference type="OrthoDB" id="1819400at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="370" mass="40183" checksum="96B9F8DB09980EFB" modified="2014-06-11" version="1">MLSTRALNRATLARQLLLERADVPVLDAVAHLGGLQAQEPQEPFIGLWSRLRGFDPAALSGLLVDRRVVRTHLMRRTVHLLPTDDVLAWRSRFDPMLRQRLLGVYRRDLDGIDLDALAAEGARLLADGQPRTTAEVGRLLSERRPGPAPGAAPSPAPAPRILGETVVTVLVPTVQLPPRGLWGATGGVRVVPLETWVGRAVAPDTEAVGEALIRRYLAAFGPAATADLRAWCGLAGLPRAVAAVRDALVSFRDERRRELLDLPDAPRPDPDTPAPVRFLPAFDNAILGYDDRTRIVDDAHRGLSVAGERAVLVDGRVAALWTARDATVEVTPLRRFSRAERTAVAEEGRRLATFLSGGKSSRVRVNASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0F9</accession>
    <name>A0A011A0F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphosugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853096.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4158"/>
    <dbReference type="HOGENOM" id="CLU_012520_0_0_11"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="30"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="196"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="365" mass="39147" checksum="B1309AB9208588B6" modified="2014-06-11" version="1">MTGADATTREIWQQPALWREVDTDPAAGFLRPLLADPDLRIVLTGAGTSAFAGGLLAPALSRHRRRRVDAVATTDIVSNPADYFAEDRPTLLVSFARSGDSPESAAATALADHCLTDVHHLIITCNPDGRLAREHGVRERSHVLLMPAASNDRSFAMTSSYTCMVLAAWSALGGGTDVDALADAAEQMLKDHDADTRELASRGYQRIVYLGSGPLQSLARESALKVLELTAGDIVAYADSALGFRHGPKSVLDAKTLAVVYVSDDPYTRRYDEDIALELRSALGPDHVRVVAGRPSERLGTAGVWYVDGLAGAPDVVLSLPFVVVAQQLALRFSLALGHTPDNPFPSGEVNRVVQGVTIYDRPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAI9</accession>
    <name>A0A011AAI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847418.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.49"/>
    <dbReference type="HOGENOM" id="CLU_018808_8_3_11"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="569" mass="58987" checksum="AF1B8D034D46B1E1" modified="2014-06-11" version="1">MTVDTILAAEASGTSSGARTLTIVLFLLFVAATLGITIWASRQTRTATDYYAGGRSFSGFQNGLAIGGDYMSAASFLGIAGIIALNGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRFTMADVLSFRMRQRPVRTAASLSTIVVSIFYLLAQMVGAGALVALLLGIKAGETFLGMTADTAKIVTIVMVGALMIVYVTVGGMKGTTWVQIVKAALLMTGAALMTVLVLWKFNFNISTMLGEAAEASGKGSAFLEPGLRYGVETAGDATKTLISKLDLISLGLALVLGTAGLPHILIRFYTVPTARAARTSVNWAITLIGIFYLMTLALGFGAAALVGGKAIAAQDAAGNTAAPQLAEELGREYAGDGGGAILLAVIAAVAFATILAVVAGLTLASSSSLAHDFYANVIKRGQVDERQEVNVAKISAFVIGAISIVLAIFAQQLNVAFLVALAFAVAASANLPAILLSLFWKRFNTTGATAGIYGGLIAAVGLVFFSPVVSGKGVNPTTGKSLSLFPADVDFHWFPLDNPGLVSIPIGFACAIIGTYLSKESDKDKWAELEVRSLTGSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB61</accession>
    <name>A0A011AB61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxyanion-translocating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847764.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.259"/>
    <dbReference type="HOGENOM" id="CLU_058953_0_0_11"/>
    <dbReference type="OrthoDB" id="1148570at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="33888" checksum="C77F8E95C2C8D33E" modified="2014-06-11" version="1">MPEDLIAFPQARLHIVTGKGGTGKTTVAAALALALAAGGRRTLLVEVEGRQGIAPMFGLDPLPYAERPVAVAPEGGEVRALAVDAEEALLDYLEMFYKLGRAGRVLKKLGAIDFATTIAPGMRDVLLTGKVKEAVTRADRGRRVYDAVVMDAPPTGRVGRFLNVNAEVAGLAKVGPIKTQSDGVMAVLRSPMTAVHVVTLLEEMPVQETADAVTELAGIGLPIGAVLVNAVRGTSLADAKVTQAELKRGLAAAGLPADRATVKGLADEVADHVRRASLEQRLRGELTELGRPVVDLPFVPEGMDTDGLYELADVLRKAGVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABH1</accession>
    <name>A0A011ABH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847952.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096760_0_0_11"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="18104" checksum="806852BAAF021AF8" modified="2014-06-11" version="1">MTFDAVRPAGDDELAGLAEVEKASEAPFIEAGIALPPEYMSQDELRKCAIVLVAPGPSGAPVGFAAVDAVDGAAHLSQLSVDAAYGRQGHGRGLLAAVIGWARRGGFPAVTLTTFRDVPWNGPFYRRYGFVELDEADLTPGLREARDHEIAMGLDELSPRCAMRRPLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD78</accession>
    <name>A0A011AD78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein, ATPase CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1051"/>
    <dbReference type="HOGENOM" id="CLU_005379_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="64"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21092" checksum="A57260897FD8B5A6" modified="2014-06-11" version="1">MESVEQRVRDLVRRRGVDPMGDPAAVGLLIDEVLATSPLVPSETRQAVLDAVAGLGPLQRFLDDPTVEEIWVNGPGRVFVARGGRSELTTTILAAGQVEELVQRALEHSGRRVDLSTPFVDAMLSDGSRLHVVIPDVTREHWAINIRKFVARAHSLVEAVALGTLTPHAAGFLEASVVAGVNVIVSGGTQAGKTTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADF4</accession>
    <name>A0A011ADF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848870.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1127"/>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_11"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20154" checksum="8B055114F92A0D51" modified="2014-06-11" version="1">MTAPAFTLTDLTGEYTLDPTHTRIGFVARHAMVTKVRGSFNEFEGSAVVDGDNPEKSSAKVTIKTASIDTRNEQRDGHLRTNDFLDPETYPEITFVTTAVQAVDADNYEVTGDLTIKGVTKSLTIPFAFEGAAKDPFGNVRIGFEGSVTINRQDFGITWNAALETGGVLVSDKITLEFEVSAIKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADU3</accession>
    <name>A0A011ADU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1262"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="303"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="446"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="700" mass="75835" checksum="4BA03FCDF84737F5" modified="2014-06-11" version="1">MTALRDPGQSDSGSLLGRRWAAVIGDTSYVTVSDAQLAQLLQDLVDRLRTAVRAEPPDTDVAEEAGAALVGAHFTGVDALQRSIAMLAAELDRESRPRTATWTVIGAFAAGYTRALREVTLTEQESIRRADLIARTRTEQALRASDARFRAVFSGAAVAIGIGDVQGALIDVNPALSEMLGYSSDELRGRSVLSLVHPDDVADVAAEVYRALTEGGREHVRVEKRFVRRDGEAIWGLLTVSMVPGEDGEPGYVVAVGEDVTDLHRLQTTLRYQAMHDPLTGLPNRVMFSERMDQAFETAADDARLGVLFIDLDGFKIINDTLGHDIGDRLLVMAAERLDRGVSSSGHLVARMGGDEFVVLVEQSGGEGEVTALAEKLLTELCRPCQIDEHLLTVSASIGVVERPVAATDRSELMRHVDAALYWAKADGRNQWSVFDSARSEAEAMRYAVSASMPAGLQRREFYLEYQPITDLDDGRLRGLEALVRWRHPYFGAMRPDDFIGIAEDTGLIVPLGRWVLEEACREACSWAELMPDPPFVSVNVAARQAADPALVDEVRAVLEQTGLPPERLQLELTESAAMGPAPIDTLHALAALGCRIAIDDFGTGYSNLAYLRSLPVTSLKLASLFVAGLQPVPGLDGDVDAAIVATLVSLARTLRLTVTAEGIETQTQVERLRALGCHLGQGYLFGTPMPAGEVRKLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE10</accession>
    <name>A0A011AE10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849066.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458677" evidence="2">
        <location>
            <begin position="30"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="51"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="35570" checksum="950D3EEDD33E67E6" modified="2014-06-11" version="1">MARTRTVFSLSFVAIIALVAVVAGVVVGRATGSGSGGGGSGDGGAASGTRIDVIIKASDSSFWQVMLAGAEQASDDFGIEVDTFGPTSETNIDEQVQLVENSISRGVDGIVIAPNSSSALDSVIERARKAGVKVITVDTRVTTSSEGFIGTDNVKAGQQAGRRMCELLKAQGRTSGAILVESSVAGIQSLVDRDRGFRQGLAEGCPGVDAKLQRYNNNDINTAASQVNDALTANRNLLGVFADNNTSGVGAARAVADNKAADRIPVVAFDSDPQENAALANGTIDALIVQNPYFFGYQGVLASAMAASGRTPPREIDPGAVVADQKNRTTPEVKSLLEPPTAEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEP1</accession>
    <name>A0A011AEP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="22073" checksum="FE81E1702087E58B" modified="2014-06-11" version="1">MAEGTLAGMRTTRQRTAVHAFLKETPEFRSAQQIYTALRARGVELGLATVYRTLQTLAEAGEVDAVHGVHGEQMYRHCTPVHHHHLICRSCLATIEVTAPASEAWVDAVVRDSGFTDVSHRVEMFGTCADCAAVGTKPRPRIEPGAQSQTAPPGARRPAATGRRSGPGTPGGAQAAVTTGVRDGRARAEDQPRRCRRAPMSQQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AES5</accession>
    <name>A0A011AES5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569910.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19542" checksum="1544A70EC5674730" modified="2014-06-11" version="1">MLRHRENHYEGLDALIATRSDALLATAGLLAGGREAGQDLLQAAIEKMMRQWHRIEGDREAYLRRILYHLAVDSWRRRRRRPEVLTDLAPAVAQPDGAGALTLRLALVQALGELTPRQRAVLVLRYFEGLSEVEIAGALGCSTGTVKSTAARGLKNLRAHTASWPLEDAPEPKGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFL3</accession>
    <name>A0A011AFL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849882.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1859"/>
    <dbReference type="HOGENOM" id="CLU_008615_3_2_11"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="399"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="603" mass="64349" checksum="D8B8716516E30C1A" modified="2014-06-11" version="1">MTTGIDDGALPAAAPYAADPAAAPASWGPSLSPSGDTIAYVSDRSGEPRLWTSPVGGGDPVLIETGPEPVEQVRWSPRGDWIAVLIAPGGSDRTEIWVIRPDGTDLHQIGGFGRTNGWFGHWSHDGASLAVAEADAIGWSAAHLIDPSTGWRVTVGEADLRAAVDVSRDGRSALVRCGPRSARWLEIVDVESGSSHRLYPGEGEGSTDVGHFAADLVYVRTDVGRSLPALVAVPLGTDGVPRVVASRDDAELEYFTLSEDGTLAALLWNVFGGRSEVSLLDLRTGEQRAVTDLPGDVVGHLSLSGDASTLALTAEGPSLPPTIWTVEVSSGAAKPVTYPPPLPAASIAPELHRFEAHDGLELTGWLYPGSGAPGPTVIHFHGGPEAQERPVYNPLFRELVSRGITVFAPNVRGSSGFGRAFVNADNVEKRHDGIEDVRSCARYLLDAGIAAPGRLGVFGRSYGGYLTLVALTWFPDLFAVGVDTCGMSDLQTFYERTEPWVAAAAVSKYGHPEDDRELLRELSPIHRIDRLTAPLLVVHGTNDTNVPLYEAEQAVAALEARNAPVQYLRFEDEGHVLLKKPNRVVYVHKVADFLSTHLTPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH18</accession>
    <name>A0A011AH18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">CryarDRAFT_2401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570051.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2364"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_11"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="293"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG81291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="678" mass="75509" checksum="65AD7520F0487C06" modified="2014-06-11" version="1">MSAAQAVHAPAPVVVPAGTTAADALVAAGVPVEGGAAAVVVRDAEGALRDLEWAPDADAEVEPVFLDSPDGLNVLRHSTAHVLAQAVQDVFPGTLLGIGPPIENGFYYDFLPEKPFTPDDLKRLEKRMQEIIKSSQRFHRRPITDDEARHELAHERFKLELISLKGSADAEGANVEVGEGALSMYDNLDRKTGERVWTDLCRGPHLPTTRNIPAFSLMRSAAAYWRGSEKNPQLQRIYGTAWPSREALKDYLNLLAEAAKRDHRKLGAELDLFSFPDELGSGLPVFHPKGGIIRREMENYSRQRHEEAGYAFVNTPHITKGHLYEVSGHLDWYADGMFPPMELEGANYYLKPMNCPMHDLIFRSRGRSYRELPLRMFEFGTVYRYEKSGVIHGLTRVRGMTQDDAHIFCTQEQISEELTSLLKFVLELLKDYGLDDFYLELSTKNPEKYIGDDAVWERATETLRRVATDSGLDLVPDPGGAAFYGPKISVQARDAIGRTWQMSTIQLDFMLPEKFELEYQAADGSRQRPVMIHRALFGSIERFFGVLTEHYAGAFPAWLAPVQVVGIPIGDNHVSYLSDFTARLRSQGVRVEVDSSSDRMQKKIRNAQKQKVPFMVIAGDDDVAAGTVSFRYRDGSQRNGVPLDAAVEHVVEVVRSRTNESPSAPPETVVAEGVIAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI71</accession>
    <name>A0A011AI71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851113.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2773"/>
    <dbReference type="HOGENOM" id="CLU_020336_13_5_11"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31879" checksum="40B98F1121FE87DE" modified="2014-06-11" version="1">MTGTPAWLTDALAADVELGVVEVDGVAIHYRAWGKPGNENGIVFVHGGAAHSRWWDHVAPFFAGDRRVVALDLSGHGDSGRREEYLMARWADEVLAAAAHGGAGPNPLVIGHSMGGMVAITAARLRGTELAGAVAVDTPFWEDQPEEQAAGAQQAFGPLRRYPSREAALKRFKLIPEQDGNDPAIHAHIAETSLRAIDGDWNWKFDPNVFRGRGRPVPLELPRCRVAVFRAEHGLVPPDMGERIAERLGRVVPVVEIPLAAHHVMIDQPLSLITALRTLLADWTHSEPHRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIR7</accession>
    <name>A0A011AIR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2991"/>
    <dbReference type="HOGENOM" id="CLU_066193_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="30997" checksum="E6240B28320CEE23" modified="2014-06-11" version="1">MRVEYVSRVPRPPLDGLIDDLYYLDGAPPYARFTVPPAPSALLVVNLGAPFRIRGGADLEAAEYADGCVITMPTRAYEFGYPPDTRSVGVHVKPWGLAPFLPMPAAELRDRPVAVEQVWGRSAVARLRERLAAAAGPHEMLTLLEDELRRRLGAAAEPGGTTGLELVRHASGVIAATGGTVAIGDLTTAAGVSSTHLARRYTELVGVTPKRLARTHRLMATVFAIDPAGPIDWGALAHGAGYFDQAHFGHEVRALTGLTPTRYVEVRQRFRREHPGHVLDGWPLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ12</accession>
    <name>A0A011AJ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3103"/>
    <dbReference type="HOGENOM" id="CLU_2092732_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043993">
        <property type="entry name" value="T4SS_pilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18895">
        <property type="entry name" value="T4SS_pilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="116" mass="12104" checksum="15B089491427FA4E" modified="2014-06-11" version="1">MAVFAPDHPRLKGAALPRPRPGPRRRVPQPHKGGTVYIAVNSLPEIIANITVWVVGLLVGVATLFLTIGGLRIMAAGGDPTEAEKGKSAIRSALIGYALAVLAPILLGIVKSWLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK93</accession>
    <name>A0A011AK93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725726.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3529"/>
    <dbReference type="HOGENOM" id="CLU_052868_1_0_11"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="29453" checksum="30144C24F3068E6B" modified="2014-06-11" version="1">MSDDTQNALREQVRDRYAQAALTVLDGATDDASCCGPSDRSGPPEALEIDERFGAGLYGDDTDGLPAEAVAASLGCGNPLAVADLEPGERVLDLGSGGGIDVLLSARRVGPTGRAFGLDMTDEMLALARANAAKAGATNVEFLKGQIEAIPLPAGSIDVVISNCVINLSTDKSAVLAEMFRVLAPGGRIGISDVVAEDHLSAADRAERGSYVGCIAGALSRTEYLDGLAAAGFTDASVAFTHEAGDGLHGAIIRATKPTAPAADLTATELTATELTATGRTTDRSSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKA8</accession>
    <name>A0A011AKA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852183.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3550"/>
    <dbReference type="HOGENOM" id="CLU_018204_5_1_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="228"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="364" mass="38713" checksum="AF3DACDECA8B0F70" modified="2014-06-11" version="1">MRSELDDDQKALADAVTRLVRRRSEVVDLRAAVASPLGYDTTLWTTLCEQIGAAALAIPEDDGGAGFTLVETFVVLERLGAELTPSPLLGSGVLAAQAILAAAGPEDRARLLPGLAEGRTTGALAWADTRGRWRTDGSDVRAERTDDGWRLSGTSPLVLDGTDADVLLVVATTPDGVGLFEAGSGVRRDPTPALDPTLRFATVHVDGAPATPLATDAGPALSRLRDVAAVAITALQVGAAQTALDRTVEHLTTRVQFGRPLGSFQALKHRVADLYVQVETARSMFLAAARAAAHDPDDLPYRAACAKAWCSDAFSAVTAEMVQLHGGIAITWEHDAHLYFKRAHATAQLFGSAREHRRRLLEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKQ9</accession>
    <name>A0A011AKQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="25238" checksum="5849C19E8DBC76B2" modified="2014-06-11" version="1">MEENFNLEFLFHLASVRGVSDPKPPLRRDAERNRQLLLRAAYELMATEGVGVPYEDIARAAGTGMGTMYRRFPQRQDLLDALFSDHIDTVTDLAEQAARSDDAWAGLTWFLERQLELEAQSRGLGELLRSRNQATESVRRAHDRMTPLVAGLIDRAVRAGQLPAGATPADFAAAHVMVGSVLDASRASAPELWRRALVVVLAGLRHADLSGDPPDETVIDLLYHDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFJ0</accession>
    <name>A0A010YFJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847331.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.7"/>
    <dbReference type="HOGENOM" id="CLU_036034_0_0_11"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG78995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="33842" checksum="83B48CEC9825CD05" modified="2014-06-11" version="1">MASDVQIIGAGIAGLACARAIAGAGHRVVVREAADTVGGRMATRVLDGRPVDLGASYLTCRDDAFRTVVDDWVRRGLAHPWARAFTVHNTLGSERTEDGPVRYGSSGGLRSLVEDLATGLLVSLDDRVTSVGPGPRVNGWPVDAVVLALPDQQARRLLDPECVEELAATDSPWSPGLAVAAGWAERRWDVDGVFVHDDPTVEWIADDGRRRADSAPVLVAHTTADFASEHLDDPDQAIGPVVDTVRSILDITDEPRWTFVQPWSDARPLRPRATPYHFGEARIGLCGDAWGSPRVETAWMSGHRLGLEIARTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFN2</accession>
    <name>A0A010YFN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847424.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.53"/>
    <dbReference type="HOGENOM" id="CLU_089574_13_0_11"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="115" mass="12390" checksum="32437ED847FEA5A4" modified="2014-06-11" version="1">MVQPSIPADVPDVTPDSLGDDIYLLDVREQDEWDAGHAPHAHHIPMYEIPQRLAEVPTVGEVVVVCRVGGRSAQVAAYLAAQGWENVANLDGGMLSWERSGRAVVADTGLPPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFS3</accession>
    <name>A0A010YFS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569533.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.93"/>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="344"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="613" mass="66558" checksum="17E4AB7E78EBF403" modified="2014-06-11" version="1">MIVLVLLAHVVVLPFYGLYRGIDFARCLVMVAPLALLVAVAGADQLGQRVRASAATLGIVASSAVTVSFSGGEIEAHFHFFVMLFFITLYQDWLTFLLAIGFVAFEHAIVGVLAPGDVYGHSPAVHEPVKYALIHAGYVTAAAVGAILNWRLTDRADAATREVTEQLEYDNCHDPLTGALNRREFETRISEVLNRIEEPDATVVCILDLDRFKIVNDTCGHPAGDRLLTEVCWVLSEVLAPEDTLARLGGDEFGILIRRRSVEEAVGMAKAACAALGRHRFKADDRTFAASASIGVLPLFGQVRYVEEAMQMADAALYTAKEAGRGRVHVHHQGDAELNRRQSDSIWAGALLDALHEDRLELVYQPIVPTVPNDEETGRIGEILVRLCEAHGSLISPGLFFPAAERYDLLPALDRSVVAKAIKTLVAHYPPGSPTNGDLYTINLAGPSIGDETFRTFVQAQLAEHKLSPSLICFEITETVAITNLEAARRFITEMRASGIRFALDDFGSGLSSFAYLKNLPVDFLKIDGNFVKTITHDMIDRTMVAAVNQIGHEMGLRTVAEFVEDDATLAVLREIGVDYGQGYGLGRPGPLASWLADRRPAGSATGTPAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG05</accession>
    <name>A0A010YG05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083623_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="25748" checksum="4DE128D3C135B42D" modified="2014-06-11" version="1">MVRLRVEHDRIRVRTVTDTLREAIGSSGPILLDFDGPICGVFENYSAWRVAAQLRDMAEASGATIPEAIQSERDPLAVLSWSATVADPSIASVVESTLIIEETKAVRTAQATPGVVEILRKADRLARPLAVVSNNSSDAINVFLKQASLDGYVWAVIGRRKGHPELMKPHPYAVLDAADEFSANPADCVFVGDSLSDIEAGRAAGVRTVGFANRAGKFEALIESGADAVTWSMQEIADCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG43</accession>
    <name>A0A010YG43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847710.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_11"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19684" checksum="5FA878706AFA7994" modified="2014-06-11" version="1">MPKTALIVIDMITPYDYPDADRLLASAEQVVPAISTLIERADVPVIYVNDNFGSWTSNRDLIYQSALDGKAPHLVEPLRPGDETMFVVKARHSIFFQTPLEYLLGSLDVTRLVMTGQVTEQCVLYSALDAHIRHHEVVIPKDAVACIHPHLAEAALEMMELNMGAQVCSAEDVRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH80</accession>
    <name>A0A010YH80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848397.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.662"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="224"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="42645" checksum="D33DEA07B37E49C0" modified="2014-06-11" version="1">MVDFALSDEQRAVRDWVRTFVQRELVPLEPEVLRRERSGEPGISREEARALQFKARESGFWGILTPEEYGGMGLGAITASLVEGELGRTFVPFRFGGSADNILFHGNSRQKEQYLLPTIEGERISCFAITEPGAGSDARAIRTSARRDGDDWVINGEKTFITQGNEADFVMVFAVADEGVTCFLVDRDMGWKSEPIQTMGQWGPAALVFDDVRVPAENVLGEVGGGFALALQWIGQGRYLLPSRAIGSCERLIEMAVAQANSRTTFGEPLAERQAIQWMIADSAVELQALRLLVLHAAWQVEAGQDSRQAQSMAKLYGGVKANEIVDRVLQIHGGMGYTRELPIERWYRELRLLRIYEGTDEIQRRTIARNILKGHVPVAADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHG7</accession>
    <name>A0A010YHG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684605_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="402" mass="41160" checksum="551CF718114969FD" modified="2014-06-11" version="1">MLAVLSELAGTASPHGGERALAESFVRFASDRWPLIDWQVRRLDGDAASVLATVLGEADRRVDDHVGGAVSPRPADVVLYSHLDTSLTGDPAVDAAITGRADTPAPFAVSGDTVCGFGLGVAKAPAAAAVVGFVRAAERAHASGSALNAHLLLAARGTHRTSWDGHASTGVSEYLGTFPPPRAAVVAKGGPPGVLRQEPAALYLRVRLSGAWGPLMLYPNGGLLARAGDLLTAVSAWGASYTAHRDDPTRQDGASFGLGALRAGSPEKSDLAPAGLELYCYLVLPGPVVPGEAAASLRAALGDEVSVDEMILGNGPGTPGDAPIIRVATDAYTSEFPAAPPLTGWTGSTDGVVFRAAGIPTARLGPRPLGGGADPRVDTFSGAELARWARVYERLISDSCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJD1</accession>
    <name>A0A010YJD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849159.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1370"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="97"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="34368" checksum="2F9B1674297CAA63" modified="2014-06-11" version="1">MSTVAATAAQTPPVAVTEPMANRVKKRLTSRTASIISLLIAVVWTIPTFGLLLSSFRPEREIKTTGWWTAFTNPSFTLENYETVLFGTSSTQLASYFVNSIVIAVPATIFTLTLAAMAAYALAWIDFKGRSWVFIGIFALQIVPLQMALIPLLQLFSNGAHIGSITIVPDFNLTGTFVTVWIAHAAFGLPLGTFLLHNFISEIPREMVEAARVDGAGHGAIFRKLMLPLITPALASFGIFEFLWVWNDLLVALTFTGGTKDVAPLTVRLAEMAGSRGDRWERLTAGAFVSLIVPLIVFLSLQKYFVRGLLAGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJX6</accession>
    <name>A0A010YJX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1605"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="18276" checksum="8FDE0931906D2967" modified="2014-06-11" version="1">MSATSLPRRLDARRNRDLILRVAAEAFTRDGELVSLDDVARRAGLGRATVYRHFPDRTALGFAVATERLVDLARRLETASFRELLHAVLVEQQRFRDLPRRRYTDALLTVLRPAFRRAHEEGRLRKDLELADLPIVFEMVDGVAERLVQALLDGLFEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK46</accession>
    <name>A0A010YK46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1665"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="33005" checksum="8B1950D228D55B1E" modified="2014-06-11" version="1">MTESAGLTLSARPAPSPGNGLLRRVRDHGVYLAIGVLLVFNLVFTPNFATVGNLRLQLVQVVPIAIVALGMALVVATEGIDLSVGSVMAITAAIIPLYLGYGPWLAVAAGLAAGAVVGALNGTLVAFCGVQPIIATLGVLVAGRAAALVLADGRLVEIFDPTLQTLGNGSLLGVPVTLVILAVLSTLVVVTVRWSVVGRRLVAIGGNRAAARLAGLPVRRTLLTVYVVSGALAALAGVLNTARLGASDPSFVGLLIELSAITAVVVGGTPLSGGRIRVVGTLLGALLMQLIAATVIQHDLPDSLARMIQAGIIVVAVYVQRDRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKW4</accession>
    <name>A0A010YKW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein containing a PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1934"/>
    <dbReference type="HOGENOM" id="CLU_044346_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="462" mass="48706" checksum="C4347B4C85895FD3" modified="2014-06-11" version="1">MTGDHHREDGVTDAAIGAAQTGVEPTQPDVEPTLPDAVRARVTALAVDLFPSLGPDVLPAALRRFAQFTPARRARLAGPTVVAQLAADAEFRQRLAERAVEAAGPLGAAVAAGTPPGAADPVEVAALAYLARPPHWTTLVESASATVVAAAESEQVLAASRQVERLTEQLERARANAKADAEKLRSDLATVRGEADELRVRVRELTKALRDSEQDVRRLTDAVSTEKGRVAAASSASDAEIRRLRGRLADAERELEAAKSSSRAGRVTDDMRLWLLLETLGNAAQGLRRELALGPPGVLPGDVVAADVEATAGTKTKAGSQLWAADDPARLDQLLALPRVHLVIDGYNVTKTGFPEAALEQQRTRLVASLAGLAAQTNAEITVVFDGAGRLAIAPGSPRGVRVIFSPAGETADEVIRRLVRTEPQGRPVVVVSSDKEVADGIRRAGAYAVPSVVLVKRLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKZ6</accession>
    <name>A0A010YKZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016652_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="456"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="681"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="731"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="767" mass="79640" checksum="0DB2507B3250CE2D" modified="2014-06-11" version="1">MDSFRLGIDFGTSSTVAALAGPDGRVRPLLFDSSPLLSSAVFLGPDGAPLTGADAERAGLAYASGLEPNPKRRIDDGTLWLGEREVRVVDLIGVVLRRVAEEAYRVTGRSPSGVVITHPAAWRQSRLGSLASAASAAGLGDVRFVPEPVAAAAYFVRVLGHALPVDRCLVVYDFGAGTFDVSVVRPVGPGFEVVASAGLPDVGGLDLDAAVVAHARALTGGATDAWARLDWPQSPADQQARHALWRSAKAAKEQLSRHPAADLHVPLAGADVRVTREEFEKLATPLLDRTSSLTLSVLREGGVAPEQVGGVFLVGGSSRIPLAATLLHRTLRIAPTALDYPELVVAEGSLHAIGAVPTAPGQPGSAPAFGGPPTPGAQPGSPHAVPPAPSPPGPRSASGPWGTAPAPPERRPTRKIALVAGSVAAVVLLALVAALVVLKPWVDDGPVTGATKGPTLTGHTDDVTAVAVGGPDGTLAAGASDDDTIRFWNVESGKKDGPDLTGFTIAPDEIEFNPDGSRLLTLSGSTVQLWDTGNRRNAFDTIEELDTEKGLQSPGSIADVAFVNDGKQVQAAFSYGSVLTWNTSDGKRVGTYPTIAGADKLFSDVALSPDGTRLATVASKEGLRVYDVKKKSLVGGELKTADDISSFDNLTFSPDGTRLAVTNSYDVVVFDVGSGKVVDTFEGHTGSIDTLAFSPDGKVLASAGNDNRILLWDLANHRELTTALTGHQKKTGDTTNSITGLAFSQDGNYLGSSSTDKTVILWKMTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL22</accession>
    <name>A0A010YL22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase LigD, polymerase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850066.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1995"/>
    <dbReference type="HOGENOM" id="CLU_008325_1_0_11"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="38854" checksum="C565D1AC2EE38C65" modified="2014-06-11" version="1">MASKAASPAVELIVGDRAVRISNPDRVYFDDPHATKLDIAKYYLSVGDGIVRALRERPCMLHRYPDGVFSAGVEGEKIYQKRLPKGAPDWVESVQVKFPSGRSADELCVTELASVIWAVQMSTVEFHPWHSRRANTEQPDELRIDLDPQPGTGLAEARRVGGVVREMLAELGWSGWPKTSGNRGIHIYVRIRPDWSFTDVRRAALAFAREVERRVPELATTAWWKEERGEKVFVDFNQNARDRTIASAYSIRGRAGALVSAPITWDELPDVESEDFTIRTVPARFAALGDLHAGIDDVAVGIEPLLEWSERDARDHDLGDAPYPPNYPKMEGEPMRVQPSRARTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMG5</accession>
    <name>A0A010YMG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850728.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2495"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="32129" checksum="8BDEAE56266D2F25" modified="2014-06-11" version="1">MVTETLAPPARADRTVTVATVDRRVAIFNRICVGVLIAFALLWLVPILWALDTALKPNAETVNTTWWIDNPTLAAFGRVFTDTDMLQWWASTFIASALSAVLTVATASLAAFALSRMRFKYRTLVFWFILAGIMVPSQVLMVPQFREFQSLGLLNTFWAVALPQAPTAIAVFIFKQFFDGLPADLEEAARVDGAGFFRVYWQIVLPLARPAVAAVSIFTFVWAWNSLLWPLLVLTNPDLMTIPVGLATVQGAFGIRYADTMATAVLGAVPLVAVFLLFQRNIVEGIAGTGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YML5</accession>
    <name>A0A010YML5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ORF">CryarDRAFT_2579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850803.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2543"/>
    <dbReference type="HOGENOM" id="CLU_045663_0_0_11"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="492" mass="53655" checksum="72BB0792FF193292" modified="2014-06-11" version="1">MGEIWFLTGSQGLYGPETLDQVAEQSRRIADQLGDGDLPVSVVWKPVLTDSAAILRICQEADANPDVVGLVAWMHTFSPAKMWIAGLDALRKPLLHLHTQANVALPWAEIDMDFMNLNQAAHGDREFGFIQARLGVSRKTVAGHVSDPRVGRRVAAWARAALGYAEMRTLRLARFGDNMRDVAVTEGDKVEAQLRFGVSVNTYGVNDLVEAVDASSDAEVDKLVAEYEERYQVVPELRAGGERHESLRYGARIELGLRSFLEAGGFRAFTTNFEDLGGLRQLPGLAVQRLMGDGYGFGGEGDWKTSVLLRTLKAMAPGGTSFMEDYTYDLTPGSERILGAHMLEVCPSIASETPKLEIHPLGIGGREDPVRLVFDATPGPAVVIGMADLGERFRLVANEIEVVSPSEPLPKLPVARAVWKPAPDLATSAESWLTAGGPHHTVLSAAVGVEELTDLAEMVSTELVVIDADTTPRRLANELRWNQAYYRLARGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNQ7</accession>
    <name>A0A010YNQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily protein, subfamily IA, variant 3 with third motif having DD or ED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570196.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2877"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="23861" checksum="EA4DB1BB6D709427" modified="2014-06-11" version="1">MSEFDAVLFDAGDTLIRLAGSGETLLHRAAADLGMAPLDPGEVADVWKRVLDRSSTAEEMAKGRDLSEDKHHDVWTALYRSAGAEQLAEGLSEKLYARTVAAESWEAFPDTVPTLRALRDRGTKIGIVSDTGFDIRPAMERLGIMAYVDTVVMSFQHGMCKPATPVFLAACDALEVDPARTLFVGDNPLTDSGAIAVGMHAFLLPRPAATGPRGLRHVVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNU2</accession>
    <name>A0A010YNU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="31551" checksum="90F085DAECFD801E" modified="2014-06-11" version="1">MIVQDPLEGVLTLLDARGHVSAGLTAGGRWAVAFAAPDGVKFNVVREGQCWLRVGDETVRLTAGDCYLLTRPVPYVLASDLAAPAVPAGPVFAAAADGMAHTGEGADVVLVGGRFSFGDRAGAVLLDALPPVIHVPGDQADALRWALDEIGSELRSPALGAALVAEHLAVVLFVRILRWHLGRADAAVTGWLAGLTDPVVAAALRAVHAAPAAPWTVASLADAASVSRSTLAERFTAVVGRAPLEYLTGWRMELASNRLRRGDEPVAVIARSVGYGSETAFSTAFKRVVGVSPREYRRGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNX5</accession>
    <name>A0A010YNX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2956"/>
    <dbReference type="HOGENOM" id="CLU_378044_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="2">
        <location>
            <begin position="212"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="740" mass="82488" checksum="CA7E4174ABC0150E" modified="2014-06-11" version="1">MKPLIMTVAAAGEIASGLSPDAIPSSARLFVSNQPSVDILLAAGDGEDAQRIIVMRSENDAELIVPEHLSTRRSDVVSRMTNFAERARTPGPLSLPTHWHQYKHNRYIAFFAVPPPEVNRSRWIAEVLSNKRSDVVFWAATTSKREVQLEEFEAANAVELPDFDEEWSIAFAAAAAHFEQERRTEPVDVEVRLRIRENSVAKGWSYEQWMEAVDDDQRAFITADPGKSIRLRGPAGSGKTITLTLKAIREMLRAKERNEDIRVLVATHSWSIATEIDQIVDAMGFGSTPELDVFPLLEVAQNMAPIYSENGAGSSLVGDDSYSGKREQLDQIREVLADFTSGDWITYRDATSEALRSRLDSSEPTHRTALAWDLLVEFGSVLGAARIWPGAGSDLRYYKVPRAAWMLPLAGRADMRVVYEIYCRHMASLDERQLVTSDQVLSDFLGFLQSRNWNRLRRSHGYDLVFVDEFHYFNPLERQVLHYLTRDVAVYPKIFMAMDPRQSPSLDFLGSAADQTTSLGESDSPDDDQVANFELTSVHRFTPQILTLVKHIHHNFPTFDLGQDWDIDFAGIESARSAGSLPVLISCGTRAAEEIDIYRAVRDLYSHGRIAVAVVDTRQWDRFSALAARLRQGKFHVSIITSQADTDSLRNRHHGVVVGPAEYLAGLQFPSAIVAGIPEISADPQAVMERTRFLSLLYLAISRAEEKVHILVNDDDGGAPGVLRDAADKGLVVAARGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ65</accession>
    <name>A0A010YQ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3454"/>
    <dbReference type="HOGENOM" id="CLU_083287_4_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="148" mass="16027" checksum="9ADE6511E5396C99" modified="2014-06-11" version="1">MGAMATPSSTSADPHEVLGYLLKHATQKLMALTDAALEPLGIDSKDYGALRVLAHREPTSQLQVAQTLGIDRTTMVALLDVLERKGIVTRRPDPADRRKNVVELTEQGLQTYDAAQVAYEKAESGFLAGLSPSASSQLRRTLRTLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQC5</accession>
    <name>A0A010YQC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570487.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3535"/>
    <dbReference type="HOGENOM" id="CLU_023738_2_2_11"/>
    <dbReference type="OrthoDB" id="1425894at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="6">
        <location>
            <begin position="50"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="7">
        <location>
            <begin position="320"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="467" mass="47428" checksum="ED36E207F64B0CA9" modified="2014-06-11" version="1">MRPGSLVRWARGAVAREAQVLLRGGEPTVELLRHLGPDVPTDAQVLEVLDLCIQVGEVLLSTGEPVGETSATMTGLAAACGLPTVDVDITFNAITMCFHRGNVAAPVTTMRLATYGTTDLTRIALITGIVDQVTRSRMTVPAAVAAVSEAVNARHPYPRWVATAGLAGLAAAVAVLLGGSAVIAATAFAVTALIDRLGVVLQRRDVAPFFLQVTGALMSTVATLGLLAAGALPGDTQPSLVIAAGLTALLSGLTLVGTVQDAISGFYVTAAGRAAEITLLSAGLLVGVILGLKLGLVFDLDLDPAEPLRADMAGFVLTTVAAALSAALFALAGYAPLRSLPAAFVVGGTAWAAYAAVIMLTDVGPVAASGVAATVVGLATGLSRRGSGRRTQVIVLSGIIPLLPGLTAYRGFYQLAGDDVVSGLVTLVLALSIGLAVAAGVALGDLIARPAPTRRRARPRTKDHLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWB8</accession>
    <name>A0A010YWB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848092.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793268_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="16211" checksum="CFA239C5C57DEF24" modified="2014-06-11" version="1">MDAVDALAVPYLGEAGWNQLRDAWRTENCVLVAKVARQALQSPVRLHDAAGKLAAQVWSWLGRPWVEQMMVREVVKRLPILGESQVRPVARAVQLAGMRLCHAHDKDLTRCPCFADLVEHEGERRPKQLLDAAQKGWTGLSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWN2</accession>
    <name>A0A010YWN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569658.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.590"/>
    <dbReference type="HOGENOM" id="CLU_102484_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="20313" checksum="4C5A42D77F586D8E" modified="2014-06-11" version="1">MPAEPTPPPRTRSSTVERERIVSILRAAAEAGLLTLDEADERMATCYQSQYRDELAPLVADLPDQGRGLVPPDPEEQARERRAGREAIGGHVGFVIFLGAILTTIWALTGAGFFWPLFPLGFLALSTVFHVKHRTRRERWRAHLAAAGYGPGDFAEYRAHHCGPRHHRGRWDHDYSHRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWT5</accession>
    <name>A0A010YWT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="28087" checksum="57C0416A8857CE86" modified="2014-06-11" version="1">MSSDAPLPAMYFLGHSTVLVETEGVRVLTDPVLLPRVANVLRRVAAPLDPALHSDVDVVCISHLHADHLDLASLRRLGQDTLLVVPEGAGELLHRKGFQEVVELSPGKFHDVGAVRITATPAVHDGLRTPFGPRALAVGYLIESPTTRVYFAGDTDQFDEMDDLGALGLDVALIPVWGWGPNLGPGHLDPRGAAEATGRLRPRFAVPIHWGTLHPYGIGRWMRAHLIDPPRRYAQAVTELGLSTRVLHTEPGRRVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX30</accession>
    <name>A0A010YX30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.739"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="25"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="491" mass="51465" checksum="E84309ADB16A873B" modified="2014-06-11" version="1">MVAVKTSGMSELAVPENRLLIAGSWQSPASGEALPVLDPATQQAFHQAGRATAPDVDAAVAAARAAYSGWSRMNPSDRGAILARWSQLIFQHVEELARYEAQDVGKPLSDARTNIFIAGSILGYFAGAADKLHGATLPSRSADNAGFTLREPLGVCAMVIAWNVPAILFMADAAPALAAGNTIVLKPSEYAPMSPLAIAALAEEAGLPPGVLNVVTGLGPEAGQPLTSHRGINHISFVGSSATGRAIMRSAAENLVPVKLELGGKSPNVVFADADLDAAVPAILESIVENSGQNCYAGSRLLIEEPIYDEVVARLAAAMEAVKAGPWHEDLDMGPLVNGIQHERVSGFLSGGVADGARVVTGGPGGADGWYVKPTLFDKVTPDMPIVREEIFGPVLAAESFRGARDAIDRVNATPYGLLVSVWTNDLSRALRVTQEVRSGQVSVNEFANSAIIGFPFNLAKESGFSQGGGYEAMKEYTSEKGVTIKMRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXM2</accession>
    <name>A0A010YXM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848715.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.984"/>
    <dbReference type="HOGENOM" id="CLU_376391_0_0_11"/>
    <dbReference type="OrthoDB" id="1439754at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="688" mass="72268" checksum="5335E4D3352263E8" modified="2014-06-11" version="1">MAETSGSSPDGGARAPLGALLRPGERLGWVFRDRHLFRRPFGQPPPTMGEVPADVLASARAANPHLVRNIAIALPAALIVSFVLVCGLSLLVFRGEGGGWGFLVMIVLVLAVFGVAGGLVWWGAHNAGTAARRPTALAAEQRARYDHELADWHTRKAQFEVAEQQRAEQLPEWSPAIPPPHTRRIDVVGGTLWGWEGLLTVFGSSTLASGGRLTVLDLTGEGVCRELAEVAAEAELSTDVQLFPDDLATADILSGLDQRQFVDVLVEAVHGGDGEGGGTDRYGRAADDRVLGAICAALAPGGLSVARVLAALRVLLGEPAGADGLTDAERQTIADELFSPDYRREIGPRLRQLESLLHPLAPLGSDAQPRPDAQLSCIATLSTGSTARDEVLGDLVVQRLTRGVATGGPSAGPRTIVVVGADDIARRHLERLSDVCERRGVRLVYLFRHLRGTSLQVLGAGAVGVMRLGNHQEAAEAAEFIGRQNRFVLTQLTHQLGGAETHSTAESESKSTSSVRNLSLRRPWQSISGMVGSSSRSWRSTAGHAEGTNWNNSETYQRAAEYTVEPRTLQGLPDYAMLLVTADQHGPTVTAVECNPDIVSLPRVSVDPLPPATQPTALPRPEGVQPGSARPGMPASAGPVHGQGGPPHGPGPGHGSGPGHGSGPGHGSGPGHGQGDVPPGWPQQPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY24</accession>
    <name>A0A010YY24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD family protein</fullName>
            <ecNumber evidence="1">2.8.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848890.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1153"/>
    <dbReference type="HOGENOM" id="CLU_114601_1_0_11"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="9676" checksum="B534F1AD7825558A" modified="2014-06-11" version="1">MAIEVRIPTILRTYTGGEKTVQGEGATLEALIGDLDGKYPGLRGRLVTDEGSLHRFVNVYVNDEDVRFTGALETGLKDGDEVTVLPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ82</accession>
    <name>A0A010YZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849471.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971926_0_0_11"/>
    <dbReference type="OrthoDB" id="2103160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="31157" checksum="B0F35A1556CE7519" modified="2014-06-11" version="1">MSGDLERRYARVLRLYPKAYRRERGPELLATLLEASARPKRRELPALLLGALRAHAGSDRRTAGGTWVAASRVAALMVLVYAITTAPVRAGITLAYGLPHGWWLIEQSLPELVAAPVGLLALAAAVLGRHRIALGVTSVAFLVGLGTWLTDTALEAGFFRYLFAALLLLPAVRTAPPPVSGLLRYALSAPALLVAADRIGEDVVPAVAGIVGFGAFVAVWFVALFWAVVDERVTLAVGLFFLAEALLWPIVLAVFTAGGASGNLTGLAVTMALTALVPTVLLSVSAIAVRRQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2D9</accession>
    <name>A0A010Z2D9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850962.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2671"/>
    <dbReference type="HOGENOM" id="CLU_020019_9_1_11"/>
    <dbReference type="OrthoDB" id="1744995at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="29964" checksum="681927AB4FEE641F" modified="2014-06-11" version="1">MAERLKIPKVPGTVGEMAAEFAGTLILILFGCGVVAQVVAGELGDHDSIAWAWGFGVTLGVFVAGRISGAHLNPAVTIALAVFKGFSWRKVPAYIAAQTLGAFVAALLVRWNYSEVLAKVDPGNTIKTQGVFSTLPGNGALPVSEWGAFRDQVIGTAILLFVILALTDLRNNPPLANLTPLIIGFLVVAIGMAWGTDAGYAINPARDFGPRLASYLTGYETAWSDQYGNVYFWVPIIAPIIGGLVGAALYGLLIGRFLPSDEPQEPGDLPSADARDARPSEKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z322</accession>
    <name>A0A010Z322_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851248.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056733_2_1_11"/>
    <dbReference type="OrthoDB" id="1742143at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="61"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="25078" checksum="FB9CC20ED1871D3E" modified="2014-06-11" version="1">MAILSTTAASTVSTAISAPPRVWLRVVATEIAIILVGVGAYLAVAVGAADRADAATAHAGTLVAVESALGLDVEADLATWWSGGPTRVLIADAYYVTAHFAVPIVLFGLLVLFRPAAYPRYRTAFVTASLLGVTVSWLWPTAPPRLVEGFADAPIISGLENPYAAFPSMHVGWAVWAALAVGALTANVWLRALAWLHAVITGVDVLVTGHHWVLDVVGGALTALAALALARALHPAREPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3Y1</accession>
    <name>A0A010Z3Y1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851672.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_0_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23015" checksum="FA9F98B5CA43E9E3" modified="2014-06-11" version="1">MARPTGERRSTYHHGNLRLALIDAGMGLASTGGPEAVVLREVARSVGVTANAAYRHFDTLSEFKRAVALKALTEMGAAIAAHLDRVVVAEPNDPRAAAIAHLREVGRGYVLFALEEPGLFRMAMSEPSALALPAPDADHGPDWDGRPKPDHYLMAALDRLVEVEALSPESVPGAALACWATAHGLSTLLPNLSTAMSSDERQAGIDAVLDILLKGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4N9</accession>
    <name>A0A010Z4N9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037146_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="29995" checksum="0F0CEF994F2302BC" modified="2014-06-11" version="1">MAASVFLSYSRSDRGYAEQLVPFLRAADLTVWWDFELYAGEVWTREIAQRINMCDVFLVILTPEAVKSPWVLRELHYASESGKRIVPLLLDACELPLLLAGVHREDVRGGDLPGTQFLVDLGGVASPRRKRFSRRERSTNSALPQFAAQQALLVEEVRWLMAHDRKSSVSITVPGSFLTVQLYRLDLGIRVDIGFGFGRTRIADAQHDSLTRNGWAGVDVSFGPIQKTFAISSVEDHYAAARQIVDALINAHGLESSEPLKVKKRFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4X4</accession>
    <name>A0A010Z4X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852170.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="34421" checksum="5E25F002EBC7F523" modified="2014-06-11" version="1">MARPIVADLPLTTLRLSQDGPVLTVRIDAPPHDYMTAAMQQDFLDLVRAVDADGTVRAVVVTGAGPGRYLAHYDIGDLLVAAEAAPLLPRPAARLLLGAVRAVTAAGGERLIDRSRLSGILAITRFHELVTRLLRSRVIWIAAIDGPCGGGGLEMSVCFDIRVAADTASFLLPELSIGLTTTVGAQRLVHLMGPARALRMMLEARAWSAAEAQDAGLVERVLPAGDVVVEAQAMAARYARRSPTAVAAQKRIINTAYDVGLRAGLTEEGVAQMTNVPTARTRASLRTWLSMQSADGASVFRTDPEPWADGTAVAETSLTTARDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z531</accession>
    <name>A0A010Z531_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="140"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23594" checksum="2D69A3469D70490E" modified="2014-06-11" version="1">MTTDVVTVDRDTPAKVIAQVLDARHVNAVPVLDEQRHVVGVVSEQDLLHKITYADLADADTDGWWRLLSRHHDAKAKSRASVARDLMTSPAVTVLPDATIVEAAQRMERHGVKSLPVVDGVGELVGIVTRRDLVGVLLRPDQQIHDEIVHEIFGAALLADVPDLAVEVTDGVVTLRGTLDRLTQANVAAGLVKRVDGVVHVDNELSYRTDDTVYVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z583</accession>
    <name>A0A010Z583_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852359.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="252"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="496" mass="52823" checksum="E5C9DA01C294430E" modified="2014-06-11" version="1">MLVSLSGVQHRYGATVALADCRLDIEPGEVHALVGENGSGKSTVVKLLSGIMRPTAGSVQVDGAPVTLRSPAHAQHHGIVTVFQETLVADELTSLDNVFAGTDGLFRRRRSVAAQRTAAADALTRLGADPALLDLTPDHLSLAERQILTLARALVRPWRLLILDEATSALDLATRDRLFALVNEQTTDGRSVLFVSHRMDELQLIIDRATVQRSGVTVGTVTREEATPAKLLAMMSGRAEQSAPARSGPPRTGGDDFVLLRDLTLEPGAEPFDLTLHRGRILGVAGLDGQGGSALVETVAGLRKPHGGTVGTADGVAITSHRSAFAAGVAYVPGKRQEEGLFPTLDVADNLAMAILPRLARRGFFRRSQVLATVREHLDGLGVHPSDPRYPITGLSGGNAQKVLVGRWLAAEPDLLVLNDPLRGVDLGTKVEFYALLRRLTDEGMTVLMLSTELEELLAVCDRIAVCADHRVATVLDGDAMTHDAALAAMFGQEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5D5</accession>
    <name>A0A010Z5D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase and lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852424.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3716"/>
    <dbReference type="HOGENOM" id="CLU_127145_0_0_11"/>
    <dbReference type="OrthoDB" id="1597462at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16147" checksum="E32C74A9EC218911" modified="2014-06-11" version="1">MSTIRMSKTTTATPEQLVAGITDFGPGRSTLFSASADDRLQVHDQGPTRADVTEGSGGVWERLRYDWSDPHRIVMTTIDSNLWGGASGHTYTLTRRADGMTVLDAVVVREGKNLKGKIVGFLLGTVAKGQLDKALGNTVKAIEARYAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6D1</accession>
    <name>A0A010Z6D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A/acetone carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852856.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4027"/>
    <dbReference type="HOGENOM" id="CLU_007154_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="194"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="524" mass="52963" checksum="8062C1C202E93845" modified="2014-06-11" version="1">MNRDLSLGVDVGGTNTDAVVIDGAGAVLAHTKQATTDDVTGGIRAAIAAVLAALGDDRSRVSRVMLGTTHATNAIVARRHLDRVAAIRLGAPAATEYPPLLGWPADLAGLVLAGSAMVGGGHMVDGTPIAPLDRDTILRFLDRNQFDAVAVTGIFSPSTPDQELEVADLVRAHLGPDARIFLSHDIGPTGLLERENATVLNAALYSVARAVTEALLTVVAEEGLDAVTFFAQNDGTLMSLDYAAQYPVLTIGSGPANSIRGAAYLSGAADAIVIDVGGTTSDLGVVVNGFPRESTLPREIGGVRTNFRMPDVVSLGVGGGTTVDVATGAVGPGSVGYRIASEALLFGGGTPTLTDAAALAGASIAGRSLPTQPAAVRSALRAALDTARTRLADAVERLSLGRADLPLVVVGGGGFLVPDDLPGAGPIVRTEHGDVANAVGAAISLAGGRADRIGVLDDREATIAQASEAAIAKAIQAGADPLEVAVVDVLEVPVTYTDRPTVKVSVKAAGPLARLGERAGARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6D5</accession>
    <name>A0A010Z6D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852862.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1882275_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458087" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="13787" checksum="B74E39C9F5C71E40" modified="2014-06-11" version="1">MRTSHLVIATAAASTVAALAFAPAAQAARVVATGTHSILGGQGYTKVSQSDDSPYVLTGFVTAKKTSGSKCISARVVYRTPSNSVVKTSSTATSCTTGRTVQASIPTVDPGSIDKAVLEVWYAGGTKSTKTFRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK95</accession>
    <name>A0A010ZK95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847516.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.92"/>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="41765" checksum="FED6DF9F6651D3EA" modified="2014-06-11" version="1">MTFDPADPIGIDDLLTDDEKAIRDAVRTRCDAVIAPNIAEWFESGRLPVREIAKEFGELGVLGMHLTGYGCAGLSAVDYGLACLELEAADSGLRSLVSVQGSLAMYAIWKFGREEHKERWLPAMASGDAIGCFGLTEPDHGSDPAGMRTRARRDGSDWVLDGRKMWITNGSVADVAVVWAGTEEGIRGFVVPTDTPGFEAPEITRKLSLRASVTSELVLNGVRLPSAAMLDVQGLKGPLSCLNEARYGIVWGSMGAGRSAFEAALEYAKTREQFGKPIGAFQLTQQKLADMAVELAKGQLLALHLGRRKDAGSLRPEQVSVGKLNNVREALEICRTARTILGANGISLEYPVIRHAVNLESVLTYEGTVEMHTLVLGQALTGHAAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKX0</accession>
    <name>A0A010ZKX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569582.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942390_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="31804" checksum="ACB441393DB93AF9" modified="2014-06-11" version="1">METEVVGLAREGGAIVSREEAAELASRWLGVPGDDVELREFDEGWVAFRAVADTAAGVLPDRVGDARVVVDRATGKVTSWPPLPVEEIIARSRSAPSGRFPGDVEALLRKAGWYPGRSLPDADLDRYAERLSALTADEEIKLTITGSARRFLSEFGGLTVGAAHVKPASFQPRPSEPDIDSFLFVGEDLAQAITPIGVIDDDDYPEEIVLSSDGRVFLTNFSGAYLLAESVDWAMVRLIRGRSSLLPLVGEDGQIHYVDRLGNPIDPTTTRAPSNGEGLDVAEEAEDSADQRNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLE8</accession>
    <name>A0A010ZLE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Subtilisin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.521"/>
    <dbReference type="HOGENOM" id="CLU_353324_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="541"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="840" mass="85339" checksum="403A9F0FD5D86970" modified="2014-06-11" version="1">MQPNVPAPRPAGGVPRWVAPTLVTLAGLTAVGVTAVVQPFVWVAHEILVISGYPVPGVFWPGLTVLTALGAGAPAALAWLLVKRPVIRAIARLWTLAAVCAALLGLVRAVPWSAGDAVADALEGVVALVLAFALRRWVSDAEAPGTRSPRVGTAVAVACGLLVLLPWWWVGALGGPLDVVAAALAASGLGVLMSRLRRTGPLRVPVGGPVAGLVLDALVLAVPLALLAGAFGSPGTQLLLLGVLPAGCVALACVDPVRRWSGALLVALAAFGPLAFVDAEEVTLLLVPGDVPQWAAIGTGISAWLALVAGAVVALGLVIAARRTKRAAPVTPPIAPPEAAGREAQAELTAGVSEAGMSEAGMSEAGAEADRPVGRAVGGRGRVLSGALIGVLVVSSGLLWLGPGQDGFHGDRLFVVLKNQAETTAVGDSTTDLTARRTAVYRLLVEHARRTQASLLSALRKVGADPTSYYLVNAVEVDDTPLVRAVLAARDDVAAVQPNPELRPIPEAATAGSADTRTLTGTPANLETIKAPQAWREGTDGRGIVVGFSDSGVDARHEALRDTYRGGADSWHDPWNRTTVPTDPNGHGTHTAGSAVGKKVGVAPGATWIGCANLARPLGNPGLYLDCLQFMLAPFRAGGDPFADGDPARAADVLSNSWGCPDVEGCGAGTLEPAVEALRDAGVFVVAAAGNEGPRCRSITDPIGRYDSVFTVGAVDDKKVVAGFSSRGPVPGDAESKPDLTAPGVDVLSAWPGGGYSRLSGTSMATPQVAGVVALIWQAAPSLRGDIVRTAALLRASTQNATLGSAPSCGGNARNVLGAGTVDAAAAVTLARQGEATRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLU5</accession>
    <name>A0A010ZLU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848391.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_1_11"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="196" mass="21470" checksum="15BB77D97F95D105" modified="2014-06-11" version="1">MPYVSSTVRRRQIVLAARVVVDREGLAHASLRAVADEAGIALGTLQHVFKTREALFGAVVEDLLFGQSVAPVPLGGLNQRFGDWLGETLQAVWQHVVRQSAESHLGRLEVTLYAVRTGLTHELARWQDERIRLWAGKTAALAGWSFLIPVDQVARLVMAMIDGLLIQFLADPNPERVSTDLRSAARAIAYVAEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMF9</accession>
    <name>A0A010ZMF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569729.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057473_0_0_11"/>
    <dbReference type="OrthoDB" id="1884218at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="13751" checksum="613206208E3F8484" modified="2014-06-11" version="1">MFALLTIALGRVRRRYRRNRPIVHGVPYVVVENGEPVLETMRMERLSIDDLIAAARQEGFERFVDIKMAVRARRKRIRRCRRGATCGRLSVLCVMLRGKRARPHSGHLHTSRSMVGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN38</accession>
    <name>A0A010ZN38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848889.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1148"/>
    <dbReference type="HOGENOM" id="CLU_025154_3_0_11"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="422" mass="44461" checksum="A5591B5CECD40121" modified="2014-06-11" version="1">MGTALLTDHYELTMLASALRDGSAHRECVFEVFARRLPKERRFGVVGGTGRVLDALVDFRFDADDLDFLRSAGAVDDETAAWLADYRFSGDIDGYPEGELYFPGSPVLTVRGTFAEAVLLETLALSILNHDSAIATAAARMVIAASDRPLIEMGSRRTHEEAAVASARAAYLAGFTATSNLEAGRRYGIPTTGTSAHAFTLLHDTEKAAFDGQLAALGVGTTMLVDTYDITAGIRTAIEVAGPELGAVRIDSGDLGVLAVQARQQLDSLGATGTRIVVSGDLDEYSIAALAVAPVDAYGAGTSVVTGSGAPTAGMVYKLVEVDGRPVAKRSENKASRGGRKTSVRRYRSTGTAVEEVISLSSPELGEHDRPLQVPLVRSGVRTAEAPNLLASRDHLEKALVTLPWEGLSLSAGDPALPVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNA8</accession>
    <name>A0A010ZNA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569812.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599969_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="16959" checksum="2D348CDC76FCEF90" modified="2014-06-11" version="1">MTPTELEHRLTTALRARAEQVTAADLRPPAPPAAGRRAPNRWILATVTMAAALLAIAVFVVIAQVREEPIRPSHQPPPTSAPSTGSTPGTTPAKPETGPSDGPLETTPSEPATEVPGATKFPNAEPTPSDRPLPPETSRGPASSPQDPTAAVPAETGPAPDASSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP51</accession>
    <name>A0A010ZP51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1512"/>
    <dbReference type="HOGENOM" id="CLU_316361_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="922" mass="98458" checksum="AD5BB7399B0181DB" modified="2014-06-11" version="1">MQPLRDKDPQRLGRYRLVGRLGAGGMGIVYAGVAEEPDGRTRQVAVKVIHPHLADAPEFRTRFRSEATLAARVARFSTAAVLDVDVEGEQPFLVTEFVDGPTLQDVVEEQGPLHGGALDAVAIGIATALVAIHEAGIVHRDLKPSNVILSRFGPRVIDFGIARAADLVSGLTSGAIGSPPYMAPEQFRGSAVTPATDVHAWGAAVCFAGSGTPPFGVGPPEVMLYRTLEREPGLGELDAPLRDLVAAALRKEPGERPGTQELLAALTLQRPGVLPSVPPPARVTPSDADEVSRTTVHLNSPHPLTAEFTTPPPTVGEPDEASGAVGGPVSVAEADRGAGRRGRKRRVALGTTAAAVVLAVAAGAGVIWAQWPEQNHRAVAPSKPDLTVKQYAADDAATGPAPAVPGARRGGTVTVYAQAQYWELDPVQNRYPDGMMGSSRLLARTLTGYREDGLTGATLVGDLATDTGRSSDGGRTWEFTIRPGVKFADGQAVTARDVANGIARSFGERATGFTYLQRWLAGQADFRAVYTGPTPKAPYPPGVEAPDDRTLRLTFPAPHPDLPTVAALPTTAAVPSGWRYSDADPVPVTGPYRVVTHELRKSLTLERNPAWNPATDPIRVAYPERYDVRFLPDRAAVTSLMMSDEQPGSVQLSTLDPTQIENVYDQRQTGRLVDGVGTGHRDLCFNASRVKDPARRRALALAFDPEAALNSTGTDLVGDYASSLLSPRVPGYPANPDRTKRSGDPAKARALLGDARVNLVYAFRDTPDGNQLAAAVKEAFARANVTVELRPVRQDQFAAAIARRTNPYDLYLCEYAPDYLDGNAMLGPLYSSSGIRAVGSTNISYLNEPSVDAELARIATLPDRGDAAEAYGALARRILTEFAPAIPYFDQRRLALRGSQVQGMFVSTFWAVPDVGRVWVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP61</accession>
    <name>A0A010ZP61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsI/penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847362.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.30"/>
    <dbReference type="HOGENOM" id="CLU_009289_1_0_11"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="484" mass="52352" checksum="A916A72B429EEE18" modified="2014-06-11" version="1">MNAPLRRVAVAVFVLFALLFVNLNYVQVVKGDDYRTSDLNERVRISSYERPRGLIMVEDQAIAESVETDGRYKYQRKYPQGELYAHVTGYQSMIYGNSELEAKENEDLSGESDKLFVRRITDMITGKKSKGANVILTLDKEVQAATADALEGEKGAAIALDPKTGEILSLVSNPAYDPNPFASHTDQPQKDAWKKLNGDSVNKPLLDRALRQTYPPGSTFKVIMSAALVDRGYKADSQVDAPNQYTAPQTEKFIENFHGETCGNGVQVSLEFALQESCNTVFSKLGVEVVKAEGIKEKAKEFGFGDTNLEVPLDVAASQTGEIADPPAVAQSSIGQRDVRMTPLQGAMIAAAVANNGKLMTPFLVKKVEAADYTTLSTTREREYSSPLSDSNAAEVQKMMRAVVQNGTGKRAQVDGADVGGKTGTAEDGDERQDHAWFIGYAIVDGQPVAAVAVVLENAGTSSSSSAAIAGTIMKSIIEQRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP66</accession>
    <name>A0A010ZP66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase, G6PDH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847373.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.35"/>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="35257" checksum="668D2F318D1372AA" modified="2014-06-11" version="1">MVNFGYTLMCEQAGPTALVSHARRAEETGFDFEVISDHYNPWLDAQGHAPNAWSVLGAVSQVTERVPLMTYVTCPTLRYHPAVIAQNAATTGLLSDGRFWLGLGAGENLNEHVVGRGWPPANIRHEMLSEAVDIIAALFTGEYVNYVGEHFRVDSAKLWDVPDSPPPIGIAVSGKQSAGLAAENADFLIAVEPVGDLIDQFERESGKQGAPKVGQLPICFDADRSAAVTRAHEQFRWFGNGWKVNAELPGPAGFEGATQFVREEDVAESIPCGSDPAAVVEAARPYVEAGFTHLAFVQIGGEHQEGFLDWSEKELLPALRESFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP78</accession>
    <name>A0A010ZP78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569893.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142819_0_0_11"/>
    <dbReference type="OrthoDB" id="2042592at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="114" mass="11540" checksum="F49B27DCBA07E3D4" modified="2014-06-11" version="1">MRNKLLFITGVGIGYVLGTKAGRERYEQIRRTAAKVKENPTVQEATGVLQAQAGSLVSTAKDVANDKLAGTAIGAKVNNLLGSSGSPEPTVTAGPATGAPSVHTPRPAGSNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPJ5</accession>
    <name>A0A010ZPJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847608.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.163"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_4_11"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="13695" checksum="7D69D40C165636D7" modified="2014-06-11" version="1">MISHINCVVLYVRDQQRSLEFYVDTLGWELRTDAWMADGTRWIDVAPPHARTRVALIAPPGGYVFPDTAAAPCTLTTEDAQATFHDLKGRGVEVTEPVVEAWATYLTVTDPDGYVYVVGENHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ40</accession>
    <name>A0A010ZQ40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-fucose isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847870.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.330"/>
    <dbReference type="HOGENOM" id="CLU_039041_0_0_11"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="7">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="8">
        <location>
            <begin position="248"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="6">
        <location>
            <begin position="326"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="467" mass="51589" checksum="C49937392AA92AB1" modified="2014-06-11" version="1">MARIGLLTMSDGRDYVANDIREFVQNAEKALVAALEADGHEVVVGVEEIWTNQLATSEARRVAAARPDLTIFHYPVWAFPHFTMLAAASTNGPLLLLASLDPVQPGMVGMLAGGGALDQIGRVHSRAWGGLTEEVAAQIRAATAVSRLCGSTFGKIGGRPMGMNTATANTDQWMATFGIDVEEIDQWEIVRRSEHVEQSRVTAGREWLERHAAGVHYDGKQLTPELLERQIRSYYAMRELIDEWNLDFSGIKGQPELTSHFTTMDITEAFLNDPYDWEGPKETHVTATEADMDGALTMQILKLLSGDPVLFADVRHYHSDLDIWDLANSGQHATWYAARSADPLENLAKTHFYPEVFFFPAGGASVHHIAAPGDATFARLTRLNGRYRLHVARGAFESYSDAENERLARLSTFEWPHAFTRLQVDASEFLSTFGANHIHAVPGDRVAELRAVARLLDIDWAGLGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ59</accession>
    <name>A0A010ZQ59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847899.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2092731_0_0_11"/>
    <dbReference type="OrthoDB" id="1571962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="SSF50242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015483782" evidence="1">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="116" mass="12115" checksum="C73223D5FE930A3D" modified="2014-06-11" version="1">MTALALLAASALPAHACDCVPLTPREAAAEASVVFVGTPTQRLGQPDEGSPDPVTYRFSVERVLKGEAGPTLSVSTNNSGDACGVDFRIGDRYEVYALDADGTPFATRCGGTHRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQX7</accession>
    <name>A0A010ZQX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type proline/glycine betaine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850236.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2140"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_5_11"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="353" mass="37696" checksum="08F2BE0FC29E5275" modified="2014-06-11" version="1">MITFESVTKQFPDGTVAVDDLSLEIPAGKITVLVGPSGCGKTTTLRMINRMIDATSGTITVDGQDVRSVDPPTLRRRIGYVIQAGGLLPHRTIVDNIATVPFLLGQDKKQARAHAMELLERVGLPASFAKRYPHQLSGGQQQRVGVARALAADPPVMLMDEPFSAVDPVVRKQLQEEFLRLQTELHKTIVLVTHDIDEAVKLGDLVCVLEVGGRIGQFDTPERLLASPSDRFVEEFLGDDRGVRRLSFVGSDGLSLDTERVVTSGGVADSWRLLVDADGKPSGWLAPGSEGDPLPVGRAFVLGNESLRSALDSAVLNPSGDAIAVDADGKVVGLAGQEQIMGALRGRLPSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR73</accession>
    <name>A0A010ZR73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dioxygenase of extradiol dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850366.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142293_0_0_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14281" checksum="CAC9F8A9CE3EC356" modified="2014-06-11" version="1">MSTSIQFNHTIVGARDREESARFLAGVLGVELGTAWGPFLPLALGNGVTLDFATMPPHLEVAPQHYAFLVPEESFDGIFGRITAAGIDYWADPARTKPGEINHDHGGRGVYFLDPSGHYLEVITQPYDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRP2</accession>
    <name>A0A010ZRP2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848664.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.922"/>
    <dbReference type="HOGENOM" id="CLU_066245_1_0_11"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="22617" checksum="2EE4ABF2FF72D81A" modified="2014-06-11" version="1">MSAPAHAAKAELRARCRAARARRLADLPPARIAAESRRLVAHLLAGLNERGGWSVAAYAPIGSEPGVVPGPPLLSGAPRVGLPDALREAGIGVLLPLVRADRDLDWAAYENHESLVRGPLGLWEPDPATALGVDAVLSVDLVVVPALAVGRDGSRLGRGAGYYDRALARVAPETPLVALVHDDELFDSVPTEEHDRRVTDVITPSGGWVRLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRR2</accession>
    <name>A0A010ZRR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860655.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.948"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="37731" checksum="49EC5D56FA5B78DB" modified="2014-06-11" version="1">MEYRRLGASGLEVPALSFGAGTFGGRGPLFGAWGRTGVPEARRLVDLCLEAGVTMFDTADVYSDGASEEVLGAAIKGRRDAVLLSTKTGLPTGEGPNRAGTSRRRLIESCEGALRRLGTDVIDVFQLHAFDAGTPIEEVLATLDELVRAGKVRYVGVSNFAGWQLMKSLAVADRYGWPRYVVHQVYYSLVGRDYEWELMPLAADQGVGATVWSPLGWGRLTGRIRRGAPVPPGSRLHDTASFGPPVADEDVYRIVDVLDEIAAETGRTVPQIALNWLLARPTVASVTVGARNEEQLRENLGAVGWSLTAEQVRRLDAASARTAPYPYFPYERQAGFARVNPSLLAGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRS0</accession>
    <name>A0A010ZRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114150_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="18806" checksum="725C5920A2FF258C" modified="2014-06-11" version="1">MIAAAYERPPDNWTGRILFTAVVLALFALIVWAARRAWKRRVAAHADLLPLPAGTVTDAVAASDGLYAGTTQSGEWQARVYAGGLANRAAATLHTGPEGVRIERDGSDPLFIPAAAITAARLDAGHANKVVGGAGMLVITWEQQGYLLDTGFRADHRVDNATHLREIEKVILEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSJ9</accession>
    <name>A0A010ZSJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848999.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1244"/>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_11"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="448" mass="46432" checksum="FC486FD25B014DA2" modified="2014-06-11" version="1">MTTVIEGCAVATVDAAGTEHRSGHVVVSDGVVVAVGAGPAPAHADAERVDATGCLATPGLVNTHHHLYQWATRAVSVDDGLFRWLQTLYPIWAGITEDTVGAAARAGLARLALTGCTTSTDHHYVFPASGGDVLGATISAAADVGLRFHPTRGSMDLSVKDGGLPPDSVVQPLDAILAAVDAAVSKWHDPSPGAMVRVAAAPCSPFSVTRDLMRESAAQARALGIRLHTHLAETHDEDEYCREKFGMTPVEYLADVDWLGPDVWLAHGVHLSNADVVTVAGAGTGVAHCPSSNARLGSGIAPVASLLAAGGPLGLGVDGAASQENGGMSDELRQALFAARLRYGPSGLTARDALRIATIGGARCLGRQDEIGSLEVGKRADVALWRVDGPFHSDVVDPIDALVYASPPPLARLYVEGREIVRDERLLTVDVGAAGADLRRAARALAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTB3</accession>
    <name>A0A010ZTB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative TIM-barrel protein, nifR3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1510"/>
    <dbReference type="HOGENOM" id="CLU_013299_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="7">
        <location>
            <begin position="45"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="42995" checksum="AD93F0C021AA9654" modified="2014-06-11" version="1">MRVHRRAAPVSPGGGRETLEGVSSAPTVVRPLTVGPHTVDPPVVLAPMAGITNVAFRRLCRQYGAGLYVSEMITTRALVERNPKTMGLITFAPDEQPRSIQLYGVDPDVVGRAVDMVVQENLADHVDLNFGCPVPKVTRKGGGSALPFRRKLFAQIVQRAVRATAGTDVPVTVKMRIGIDDDHVTFRDAGRAAEDAGVAAVALHGRTAVQFYGGRANWEPIAELAAALEVPVLGNGDIWEADDAVRMVTETGCAGVVVGRGCLGRPWLFADLAAAFAGRPDRVRPDLGQVATTMRRHAELLAEWKGEAWGLPDFRKHVAWYLKGYPVGSTIRRELGMVSTLTELDDLLGKLDPAAPFPTTEIGEPRGRTTGARRVVLPEGWLDDPDALTAPTDAELDVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTI5</accession>
    <name>A0A010ZTI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569909.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130432_0_0_11"/>
    <dbReference type="OrthoDB" id="1941009at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="14641" checksum="4AF035F8CC9854BE" modified="2014-06-11" version="1">MGRIHRDALAVALVCGVLAGCSGEDPKPASSPSPSVSPPVTGTVEQIASHLDCTPEIRIQAKELRQGMCGTEGALFAVTTFPADKFRDVWLYEAAGFGGWYVVGPGWTVSASTKPEAASRQKKLGGSLVDGSVVPKARPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTY3</accession>
    <name>A0A010ZTY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569940.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1721"/>
    <dbReference type="HOGENOM" id="CLU_004744_5_1_11"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040671">
        <property type="entry name" value="Pullulanase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17967">
        <property type="entry name" value="Pullulanase_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="304"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="771" mass="82426" checksum="4998C44432004A73" modified="2014-06-11" version="1">MDVDLARAAARWISTDRIVWRPADRVRLHTAPRGGLAVTGGRVTGGTGVDLLPGLRVPDLPVRELLTGQLVVAAYDADDELVDATGVQIAGVLDDLYAGAATRTLGPVWRDGVPSLSLWAPTAKSVAVRIGDGVHPMRRDGDGVWTVTGEPTWKDRDYRFDVEVFVPETGRVEHNRVTDPYSIGLAVNSTHSRLVDLGEWTGTPSPPGPDRAIYELHVRDFSIGDTSVPPEHRGTYLAFTHPDSVGMTHLARLARAGLTTVHLLPVADFSSVDDVRSAGPGDLHGFAPDGAEQQERVTAVADEDGFNWGYDPLHWTVPEGSYAVDPDARTAEVRAMVDALHRVGLRVVLDVVYNHTATAGQGGTNNLDRIVPGYYHRLDDTGVVYTSTCCPNTATEHTMAGKLLIDSVLTWARAYGVDGFRFDLMGHHPRALLVELRERYDGLLYGEGWDFGEVAGNALFVNASQANMVGTGVSTFDDSLRDAVRGGSPFDDDPRVQGFASGLFTDPNGVSPSSRDQLSALQDRIRSGLTNADAVTYVDAHDNLTLYDALTYKLPPTTSMADRIRMNTLALALTAVGPGLTFWHAGVESLRSKSFDADSYNSGDWFNVYDPTGVTHGFGRGLPPAAKNAAWWKYARPLLADAALRPTAEDVEAATASAETLLRLRASTPLFRLRDPGSVSFPASAPGVIVMMIDDRPGSTGTALVVVFNATPFATTQFVPAAAGADFALHPVQASGPDPVVRTASFVVGSGAFTVPARTAAVFVADAGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUE9</accession>
    <name>A0A010ZUE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851983.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3421"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="34988" checksum="FA8BD87378CF5624" modified="2014-06-11" version="1">MRAVVLAEPGRVEVRDDLPEPTPGPDDVVVLVRAVGLCGSDLSVVAGHRAVPEFPWVLGHEALGEVVAIGADVVDRAIGQRVVIEPNYPCGRCEPCRNGTTAGCVRRRIVGITEPGVLAERITVPAAFAWPVPDRTGPAGGIRDDDALCAEPLAVALTAVDRLGIAPGTRCLVIGAGAQGQLVSLALRARGAVPVVTDVNTERANLAVELGAEPFLRNDERFAAVVEASGAPSALPEAISRTAHDGSIALIGQSEQTSPIRTFDLVQKRLTIHGCLIYDHPGGFAATLDLLRTHDVRPGRILRHRFSFDDAATAFRTAGAAAGKSWISLGGNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUI5</accession>
    <name>A0A010ZUI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849970.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1916"/>
    <dbReference type="HOGENOM" id="CLU_069054_5_0_11"/>
    <dbReference type="OrthoDB" id="1891602at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="12830" checksum="FEDD37A5690936E3" modified="2014-06-11" version="1">MTVSDTHEHASTTDGVVLTDGAASKVKALLDQEGRDDLRLRIAVQPGGCSGLRYQLFFDERSLDGDTILDFSGVEVAVDRMSKPYLGGATIDFVDTIEKQGFTIDNPNATGSCACGDSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUK5</accession>
    <name>A0A010ZUK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852094.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086407_4_1_11"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="20207" checksum="15FFCA37C93CBCC2" modified="2014-06-11" version="1">MSGAVPAWAHEKAKLHSYNTEWVGLARAESGRLSDLLAPWLVDGVEHVGSTAVPGLAAKPIVDLMASVRDMDGVVGHCSRDLLAAGWSYVPPELDRRPWRRFFVKPDAAGKRRVAHLHVITAGHARWAEQLAFRDALRRNERLAQEYEILKRRLSEVYGSDREAYTRAKSDFIRTVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUQ0</accession>
    <name>A0A010ZUQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1997"/>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458277" evidence="2">
        <location>
            <begin position="31"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="526" mass="55297" checksum="50721338B16EA90B" modified="2014-06-11" version="1">MTLRRSPRLSLVIVSLAAAVGLSACGTTVADGEWRSVPRAGSPSAAPSAAPSSAPDTSMAKWTDCKAEIERSIGTSLSGVQVDCGAVRVPQDWANPTGATFDIAMVRVRRTDQKNRIGSLLVNPGGPGASGIELAAQTPLFLPGEIMERFDVVGFDPRGVGKSAPVDCLTAASKDATTAANPDPAPQKEFDEQVKLWRTSINPCVSKYGQSLGYYSTEQTVRDMDAIREAVGDPKMTYLGYSYGTLLGAVYAHLYPGRIRAFVLDGAVDPNLDGITASEGQAAGFEKAFDNFAAACRARGSGCPIGPDARRTLHDVLITVQKKPVAGRGGEKRTATTGHVLSAVTAALYVKAQWPTLEKAIADVSKGDPTTVFALNDSFTGRNADGSYNNMTDAFTAIGCTDDRNPPTVAKVRTLQAEWRRKYPLFGAPLAMTMLSCAVWPGTHDPYPVGAAFGAPPIVVVGTTGDPATPYANTAKLASGLGTGHIVTWQGEGHTAYPQTTCIRENISNYLLTTNPPPDGLTCPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV11</accession>
    <name>A0A010ZV11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3691"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="25684" checksum="662B6548C59D56B3" modified="2014-06-11" version="1">MARVAIVTGSSSGIGEGIARALAADGFHVVVTSATSVDAGERLAAELPGASYVRADIADPIDAVRLVETAVERYGRLDLLVNNAGVARPVPHPDLDAITADDWHRILGVNVVGTWQVSVAAVKVMEPGSQIVNITSVGGSRPLGSSIPYSVSKAALDHLTRLLAKAVGPDVRVNAIAPGPVETRLTSGSLGPRAARTAAMTPLGRLGQPADVAAMVLALTKVPFVTGEVIHVDGGINLITHVDQPRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVB3</accession>
    <name>A0A010ZVB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850356.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2222"/>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_11"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="27763" checksum="C940422806AC113F" modified="2014-06-11" version="1">MTVHSLTVPGVGTVELTVTERGEGHPFLLLHGGGGPMTVTPWADRLSDAEHARVLTPIHPGFNATPRPAALASIPALATTYVALLDELALEDVTVVGNSIGGWITAEMMLLHSPRISSYVLVDAVGIEVPGHPVADFFSLTMSELAERSYHDPAKYGIDPATLPPRAREAMAGNRVAIELYAGREMTDPTLAGRLGGAAAPALVVWGDADRIGDPDFGRAYAASIPGAGFTVLPETGHLPQIETPEALIEVVWAFADAHATMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVU0</accession>
    <name>A0A010ZVU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prepilin signal peptidase PulO-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2396"/>
    <dbReference type="HOGENOM" id="CLU_057101_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="5">
        <location>
            <begin position="115"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="25352" checksum="46FC5BE9EFDCC980" modified="2014-06-11" version="1">MEPLVSAGVVALAGWGAGPWLADALERVAVVATGPVAGEPVLAHAAAATVLSADPPARSDRAPSTSRGSGRGGAARAVGFFAPAARGRAAGVAAAAVGGVVAWAVEAPELAGMVFLAGLGLVLAAVDVRAHRLPDALVLPAYPILAALLTTGALLGGTGPAPLVRAAEASAVAFGVLYLLAVVVPAGFGYGDVKLTGLLGAALGWYGWPELATGLTYGFVYGGLGAAALLATRRLSRTDRLAFGPFLLAGALTALCTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW96</accession>
    <name>A0A010ZW96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853022.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4117"/>
    <dbReference type="HOGENOM" id="CLU_069356_1_2_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="21192" checksum="75EC55DA47BA3956" modified="2014-06-11" version="1">MSDSTRERIVAAARAEFAQYGIAGARVARIAANAKTSKERVYAYFSSKEDLYRLITAEELGAIARATRIDVTDLPGYAGRVHDYFTTHPERARLLAWGRLELGTTEGDPLRRAVAGKLGQLRKAQEAGRLDPAWDPVDVLMLINQMAMTWADQPDFVAAVPEPERAAYLAARRAAIVTAVERLFPATAPAPGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWC3</accession>
    <name>A0A010ZWC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570710.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4150"/>
    <dbReference type="HOGENOM" id="CLU_138490_0_0_11"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="14345" checksum="844FAD8113BAF9A9" modified="2014-06-11" version="1">MTSIPILKLDDVLLLSIQVDLSDQTALAMQDALAERITATGARGVVIDITALEIVDSFIGRILATTASVSRLLDADTVVVGMRPAVAITLVELGLSLGEVRTALNLEKGLALLRRAWADGAGDSPSIAPSLRAPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWS7</accession>
    <name>A0A010ZWS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048545_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="27463" checksum="D0BCF613BE29B96B" modified="2014-06-11" version="1">MPWVAAGYVAVVFVCAASEAAGTFLVDRIYLAVLLFPVSLVLSNVLGVLTFVFSVAGRPGVGVGIVVGYTGAAVLNVWLWRAVRRAYVRSKEVPAGVPPSYPPPSYPPPSYPPPLYPPPSYPSPSYPSAVPPPVSPSVAPSVASVDSPSGAPAEPPVASLDGPSQYGPPQYVPPSARRLWVLGALGLAPHIVSIVLYGIQLHQMPDHGIKAEVQATLLLSWTFFLYSMVGCGLVALSRRTRLQAGAVAGGSVLGFLAALVAGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXP8</accession>
    <name>A0A010ZXP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301119_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="11451" checksum="9FEEAB275FAD6C56" modified="2014-06-11" version="1">MTLPPLKDLVYQDCGYNVPPGFTEDFVRLHEGGWDIAERDWERIVVLVLDTDAVHPKSNGIQAIREAVEAAAAFLHDDYEWPWCPICQRGTDVERREEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXV1</accession>
    <name>A0A010ZXV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851578.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3134"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_11"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="31411" checksum="B5B0F737F383F9E9" modified="2014-06-11" version="1">MVKNRQAIRELGFAAPAGIPRGVEVLSLAQFRSRVVSGPPQRPTFHHLLTIERGSLRHTVDFTGYTVASGGWLWVRPGQVQQWGELGDVGGTLILFEPDFLDSGTVTAARLRDAHAPVVYQPAEDDRQRLTDAIVHLTRAFEAPGSLPLDIRQIVLRHLLAVLLLRLAFVPGDSAPEPSDTFLRFRDAVEHAFVRTRRLEDYARLLGYSSRTLSRATRAAVGINAKDFIDQRAVLEAKRLLAHSDQTAAQVAARLGFSSATNFTKYFHQRTGTTPIAFRAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY09</accession>
    <name>A0A010ZY09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851680.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3198"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="154"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="28929" checksum="FE694A40AF5782BA" modified="2014-06-11" version="1">MATKYAHVLVGTDGSEKADRAVRWAAREAVLRGEPLRIVHAFLWPYLRVSTAPVPGLPGTGLRQAAEDLLAAAVTTARGAAPGVDVTTSLPVGAPVGVLRAAAENAELVVVGSDGLGRVAGLIVGSVSTDLVARSRCPLVVVTGHAGERIGEPRVVAGIDGSDHHEVKAVLDFTFREAAWRTASVTVVHATRGRRADSEGDTAVPTAMAAWSDRYPDVAVRYVDDSRSPATALAAQADDADLLVLGTRGRGGLAGLVRGSVGQVLLQHARCPVAVVHGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYR4</accession>
    <name>A0A010ZYR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138346_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046268">
        <property type="entry name" value="DUF6301"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19818">
        <property type="entry name" value="DUF6301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="17744" checksum="472AAC452E748F74" modified="2014-06-11" version="1">MSTAGTVDEAMVRHLFRALADTSWSWTETALADVVSRLGWTLSRRTERIVSADTGLALEDPFARFQVDGVGGIDVARLMLTPLRVDDPIVRAAVDDVFAAVTATATVVLGTPTRRLPGAFPEVRWRGTGASIVLRASPSAVEVEWAGTSYLEQMDKLRELEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYZ6</accession>
    <name>A0A010ZYZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852245.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127139_0_0_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="15281" checksum="319567304E175952" modified="2014-06-11" version="1">MPLTIGINHVTAVTADVDRLVRFYSEMFDATKVFEGQAAHGHPRMAIVELGGTRYVKIVENRSGAPATDALGSTTERFGLAVESHDELRALRDRMVRAGARIGEIERLPTQWIMRVVDPDGAVLQVCAHARPDTTRATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ00</accession>
    <name>A0A010ZZ00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852247.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="234" mass="26081" checksum="6DA7B26CF7B38177" modified="2014-06-11" version="1">MSDEQPYRVLVVEDEPTIRSLLEFAFHRSGYQVSSAETARAALAEIDRGEPHLLVLDVMLPDTDGIELTRQLRASGNGVPVLLLTARTALRDRVAGLAAGADDYVAKPFDIEEVLLRVEAILRRTAPSSGRSAPDQVLRYADLELNVTLHEVHRAGEHIALSPTEFKLLRYLLAHAGKVVTKAQILDHVWSYGFGGDQSIIETYVKYLRRKVDRFDPPLIQTVRGVGYSLRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ72</accession>
    <name>A0A010ZZ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852374.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3673"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="33166" checksum="F84995257ADE3075" modified="2014-06-11" version="1">MTAHRRFVVLGFMSPWIVGFSVFFVYPLLSTLYYSLTSFDLINDPVFIGARNFVFLFTKDPLVRTSAANTAYLVVAVTVGRVGYGLLTALVLSRLRSRASGVFRTLFYLPALAPPVAAALAFVFVFNPGTGPVNALLNVVGIKGPLWFNDPSWSKPSLTVLALWASGEVMVILLAALLDVPADYYEAASLDGAGPLKKFWHITLPSISPVLLFAIINSIIVGLQYFTESTVAGAVASGSSDAVGNISSLGYPDNSTLTFPMWLYERGFHSYNMGYASAMATVLFGVSAIFTVLLVQRLRATAGGQEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ82</accession>
    <name>A0A010ZZ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864591.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3683"/>
    <dbReference type="HOGENOM" id="CLU_110158_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="20773" checksum="7CD8E11E44FFDCDD" modified="2014-06-11" version="1">MEEPVDTATAILASAVVLLRGRTFDDISYRALADEVGISERTIYRQYPTRAHLLAALSDWIEQTCFPLPPFVTVADFCAAAHERFRAFDASPAYAYVSARASAISPTLDAAGPAYLTRAIEAMLEVAAPTLNRRDRRRVAASLRYFSSAMFWARLRTGFDLDAAEIGDAFDHAVGTVLARLPDATWVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A033</accession>
    <name>A0A011A033_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4006"/>
    <dbReference type="HOGENOM" id="CLU_036185_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="42643" checksum="2B220CCCED12244D" modified="2014-06-11" version="1">MLLAAVVSCSSSESELSFSGEPTALPHAAVRPSASQDDRDRALIDFYRAWKDEYVHEDCGDGAYQIYSPDAAYPFVSEAQGYGLTIAAMMSGADPDARDLFDGLLTYVLDHPSTRTPDLMAAEQDADCVDKAGGDSATDGDMDVAYGLLLADRLWGSDGDVDYRDLAVKRIRAVKDKTVNPSSELMLLGDWDTTVDPQLYATTRTSDWMPYYFRVFQEATGDTAWSAIADAHRSAVADLRDPDTGLLPDFARTGGDGIEPVTGKVLETANDGDYSFNACRVPWRLGTDALLTGDASSTSAARTIDAWFRSTTGGDPGRVGSGYRLDGTREDADESNAFWAPLAVSAMTDPGGQRWLDALWTKLAENDVERGNYYGDTIQLQVMLLLSGRYLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0H8</accession>
    <name>A0A011A0H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein containing von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570719.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042261_0_0_11"/>
    <dbReference type="OrthoDB" id="1121563at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="184"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="38260" checksum="F76DAC5593D5AEDC" modified="2014-06-11" version="1">MIGPMTDHLHGFVRDLVDHGVGVTPERTIRFLRAADPADLYWTARITLTASPAEHEIFEPIFWRWFADLPVAPAPAPAGTTDTPAPGGSGGGTDPVEQHPGSDRGLAASPTAAAGTLRFGRTTRPDLLARIRRDLPGALPPVRSRRRRPAHRGDTLDVRRVAREAARTHGEVLRLRRRRRPARPRRMVLLVDVSGSMKQHAADLLRVGHAAVRSGARAEVFTFGTELTHVTSSLRAVADPDAALAALGARVLDADGGTRIGSALGAFLEEHRSAVAGAVVVVFSDGLERGDPTAMVTAVRRLRRLGHRLVWWSPLACDPAYRPVTRAMAAIADDLCVLDGVGDLASAHRALKGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABT7</accession>
    <name>A0A011ABT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848195.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.518"/>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_11"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="84"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="423" mass="44383" checksum="589BE07BC63A1487" modified="2014-06-11" version="1">MTSLLAAQDTASPARVLRCRNCGAEFPLIAIHACAECFGPLEVGYDADALASVTREQIEAGPQNIWRYAPLLPVGQDPDDRVSLNPGLTPLVRADRLAAAIGLNAPLWVKDDSANPTHSFKDRVVSLALTAAKGLGYRSVACASTGNLANSVAAHAARVGWQATVFIPADLEPSKILASAVYNPRLVAVDGSYDDVNRLTSELQEDDAFESTAFVNQNVRPYYAEGSKTLGYEVAEQLGWRLPAQVVVPIASGSLLTKIDKAFGELVKAGIVSDADWKVFGAQSAGCSPVYTAFAEGHDVVRPVKPTGIAKSLNIGNPADGPYVLDAVRRTGGSIAAVDDDDIRDGIRLLAETTGIFGETAGGVTVAVLKKLVESGELDPNAETVIFNTGEGLKTADAIEGRVGPTHRIAPSLRGAREAGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACX5</accession>
    <name>A0A011ACX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569744.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.942"/>
    <dbReference type="HOGENOM" id="CLU_020629_0_0_11"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSE_N" evidence="2">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="628" mass="68581" checksum="14846DE18C4D40EE" modified="2014-06-11" version="1">MQETPIGELLVGAGHLTPEQLDWALTTQRRTGSRLGAILVATGLVRRQVLYRLLADRWDAPFVDVAGSSLDPTLLGRVTPEALAEEGWIPTRRGPDGAPVVATVERPTPAIKSRIEKALGEPVHLGVTTEGDLIQGLHRGYEEIIADQASLGLWRRDAAQSARTVLFPSQKVLGGALLALIAGAAVAAPTATVAALMAGLSLALLAGVAFKFAVCMVGARHERFETVSDDDVRALSDENLPMYTVLVPVYREANVVKDLLANLGDLDWPKERLEVLLLLEADDTETIEAARAADPPATFTFVVVPDDLPKTKPKACNVGLYLARGDFLVIYDAEDRPDPDQLKKALIAFRRGGDDLVCVQAALNYWNAEENWLTRMFTLEYSFWFDYMLPGLERLRLPIPLGGTSNHFRVDALRELGGWDPFNVTEDADLGIRAAALGKTVGVVNSTTYEEANRAEGNWIRQRSRWIKGYLQTLLVHARRPRALVRHAGLRQVSAFLLLIGGTPATFLATPPLYLLFLASMVLSPTTLAGLFPGWVLWISLVNLLLGNGLMIYVSMMGAFKRGRYALVLWALVNPVYWLLHSIASYKAVWQLITKPHYWEKTLHGLSTVAPGGAGAGVTGLEKQPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD55</accession>
    <name>A0A011AD55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1022"/>
    <dbReference type="HOGENOM" id="CLU_1459820_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045382">
        <property type="entry name" value="DUF6529"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20139">
        <property type="entry name" value="DUF6529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="21631" checksum="77AD07C2B3E49D3E" modified="2014-06-11" version="1">MTGNPEPDESPTRPFAVPPTVLAPPPPPRPASASTVTKLIVPLAVGAGVAVVLGVYGKVHTPTGIAVSVAGFSGPLTVKVWLATAAIVFAVVQLVTALAMWGKLPLRGAWVSPVHRWSGRIAFVLTIPVVVHCLYALGFATYDTRTLAHSLLGCVFFGAFTTKMLVLTKHGLAGWVLPLFGGTVFAALVGVWATSALWFFSTSGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADD3</accession>
    <name>A0A011ADD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate-1-semialdehyde aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_375834_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aldolase_II" evidence="3">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="804" mass="85887" checksum="1020EE8CEEAEBDBB" modified="2014-06-11" version="1">MKHLRSRQHVVDMCRTLLERGYLKATEGNVSVRVPSHDCYAVTPSNYDYDKMRPEDICLVGFDGKPLPDDDASGLAPSIECGMHANIYRERPDVNAIVHTHQPYASALAFLRKEIPALTDEQVRFLGRKVAIIPYAPSGTSFLAKKVQKRVTSGDNAFIIANHGIIAVGTDPDRAVFNMALLEKVSLAYLLALTTESGKIYTIPDAIREVAFTKLRKDEKKIAAQITAAVRPIRVPEGEDLPSAGTPDLAGSAALQHPGAAEPATDPAALQHPGAAEPSTTPAGTGPLSAIADLASAGGDDPVGAPSEPTPAPAPEPTEPTPDHGYAISTYPDVPDTMRRLKALVAQPVRGLRHDAMLDVLNYFETKCTASKEITDRAKTRIPGGVQHNLAFNYPFPLAIEKAEGAYLTDRDGNTYIDFLQAGGPTLLGSNYAPVNEKVADVIKASGPVTGLFHEYELKLAEIIHTYMPHIEMYRSLGSGTEAVMAAVRGARAFTGKNVVIKVGGAYHGWSDTMVYGLRVPGTYRMNAKGIPFGATGATREAFPHDLGLLKRKLIENRVRGGTAAVIVEPVGPESGTRPVPEDYNAKVRELCDEFGALLIFDEVVTGFRLGMGGASGYFGVTPDLTVLGKAVSGGYPMAGGVGGRADVMAVFGSGLDGKNGSHVQVGGTLSANPLSCAAGYFAIEEMARTNAPVKAGRAGDRLTRGLQRLIGDFGLPYVAYNQGSIVHLEVSGVMLLDMRHPMKLLKENKPRKRLMEQMSAAYAAHGIITLAGSRMYTSMADTDEVIDDALGRFEQVFSLVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADZ7</accession>
    <name>A0A011ADZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849058.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088222_0_0_11"/>
    <dbReference type="OrthoDB" id="1544298at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="243" mass="26300" checksum="022F041C1F0DEB9D" modified="2014-06-11" version="1">MLLSVVAVPPSSGRIEQITEQIAERQSPTPGWLVVFTGLLALMFVGTGVIRRLATSSHEGAHAMAASLTGRVGGVTLPRKGDAATEVVVAGLADFVTTFVGYLGPPLFGLLGAWLLSRHHPVAVLWLAIVLLVVLFWLVKNPFGLFFIGAVDGVLLLVAWNTTTGAQTVVAYFLVWSLLLRGMRHISPFLKAEHRKIDRKAKGKSDYLVLRDLTYVPQIVFVVVHLGLCWAALAFGAWLLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE36</accession>
    <name>A0A011AE36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1330"/>
    <dbReference type="HOGENOM" id="CLU_014793_3_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="320" mass="35970" checksum="95C7BA518C110BB8" modified="2014-06-11" version="1">MTTDVVEPSTRVVEADDSAVPDRDLVGTYLHEISRTPLLNAEQEVELAKQVEAGLLAEHWLDEGTFPEYITRSELTRLVAEGRRAKDAFILANLRLVVSIARRYTRSAMPLLDLVQEGNSGLVRAVEKFDYQRGYKFSTYATWWIRQAISRAIAQQARTVRLPVHLVEEINRMRNVRRDLTRELGRDPEIPELAKSLDIEPTRVEELIRWARETVSLDTPVGEDGETSLSDLVADGDEPSPEDVVIAAIQRDGLGQMIERLDPRSARIVRARYGLEDGRQQSLTEIAGTLGLSRERVRQLENAALHQLRELAASEGVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEI1</accession>
    <name>A0A011AEI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1494"/>
    <dbReference type="HOGENOM" id="CLU_096072_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="12897" checksum="0F0A5A5DBCF83C02" modified="2014-06-11" version="1">MALLGEVEEFRSAQELHELLRQRGESVGLTTVYRTLQALADAEEIDVMRPPGGEHLYRRCSSGHHHHLVCRVCGRTVEVAGPTVESWANRVASEHGFADVSHTLEIFGTCAECAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEQ2</accession>
    <name>A0A011AEQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849448.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1568"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="32092" checksum="A96AA84E4DFE3804" modified="2014-06-11" version="1">MAPIDRAEIREFLSSRRARITPEQAGLPVYGGHRRVKGLRREEVALLAGVSIDYYVRMERGNLAGASESVLDSLALALRLDEAEREHLFALARAAGPETRPRRAQPTSVRPVVQQVLDAMTDAPAWVRNARFDIVAMNRLARALYAPVLADPRRPANTSRFVYLDPAAREFFVDWDRIADDAAAMLRLEAGRDPHDRALIELVGELSTRSEVFRQRWASHDVKYHRSGQKRLHHPVVGRLDLDYQAMEFPSEPGLRLNVYTAAAGTPAADGLKMLASWAATHDLTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGH2</accession>
    <name>A0A011AGH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted/surface protein with fasciclin-like repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2181"/>
    <dbReference type="HOGENOM" id="CLU_031281_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="19353" checksum="3D96FB11FA3BFFB7" modified="2014-06-11" version="1">MAACGGSDSSNSSNSSDTAAAPAPSASEMTSSGTSGMDQPFGAACSAVPASGAGSFSGMAQDPVATAASNNPVLSTLVTAVKTAGLVDTLNGAKDVTVFAPTNDAFAKIPEAQLKAVLADKDMLTKILTYHVIGQKVTPEQLGTAGPFKSLQGGEVTVSGSGEDFTVNGDSKVVCGNVQTANATVYLVDTVLMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH64</accession>
    <name>A0A011AH64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="12" type="ORF">CryarDRAFT_2457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850637.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2420"/>
    <dbReference type="HOGENOM" id="CLU_033347_1_0_11"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="11">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="32259" checksum="5D86623F9B12EC00" modified="2014-06-11" version="1">MRLVFAGTPSVAVPPLERLVRSGHEVVAVVTRPDAPAGRGRKLQRSPVGEVADAHGIEVLTPAKAGDPEFLARLASLAPDLAPVVAYGGLIPPSALVVPRLGWVNLHFSLLPAWRGAAPVQHAILHGDELTGAAVFQLEKGLDTGPVFGQLTEVIRPDDTAGALLERLSEAGAELLAQVVDGIAAGALQAVPQPADGVSLAPKLTAEDAHLDWSVPAFAVDRRIRACTPAPGAWTTFRGDRVKVGAVRTAPDAERLEPGALRVERKRILVGTATDPVVLGEVVPPGKKAMPATDWARGARPEPGERFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHB1</accession>
    <name>A0A011AHB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2481"/>
    <dbReference type="HOGENOM" id="CLU_102567_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="13942" checksum="0F59D331FD83A72E" modified="2014-06-11" version="1">MTTTPSGASTVEVIGGTPAAASRPSPRPVREPSTRSGPPATVRSGPPADVTPIRASPRPPSGRQRHDEKITVYLSSGELLELERTRLDLRARHGIGIDRGRIVREAIAIALAEYDANGEHSVLVRRLASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHC1</accession>
    <name>A0A011AHC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2491"/>
    <dbReference type="HOGENOM" id="CLU_026490_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="41074" checksum="418FB452FA417FE0" modified="2014-06-11" version="1">MFATYVTDNFRPLRTVEPDPPFDDLEPMLTGARVVAIGESAHWVREYTLFRYRLLRALAARGGPVVFALESGFSEGQLVSDWLSGGSGDVRSVADEGITYRMGQCAEMRDQLTWMRSAGVGYAGLDLPGSAATPLPALHRLPAGLPFVEDLITRTEKFASEHALHTYAAYAALAETDRDALTARWASLSAWADVRVPGLDPVVRHEIRLGALFDQMLRGHATRSALAAAARDRAMAETVLWLLERHPDAVIVLGAANGHLQRTPLSVPGLEVSPAGHHLASHLGPEYLAVAVTAVGGRTPARRPAPSAPGGVEVTVVDLEPPRADAIEAALPGRLGVLDLREARGLPDAPTAIRVQHTYVEGPVAEAYDFVVGVPSTTVAGFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHJ8</accession>
    <name>A0A011AHJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosine/uracil/thiamine/allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570095.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2574"/>
    <dbReference type="HOGENOM" id="CLU_021555_0_2_11"/>
    <dbReference type="OrthoDB" id="326558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="54297" checksum="E79A44298BFD87F5" modified="2014-06-11" version="1">MSETTLPAETTHSHAAGDGIIKPGYDPRLANEDLAPLKNQNWTSYNFFAFWMSDVHSVGGYLTAGSLFALGLVAWQVLIALLIGITIVYFLCNLVARPSQRTGTPYPVASRIPFGVLGANIPAIIRGLIAVAWYGIQTYLASAALIVVALRLDPGLAPWADVDQHGFLGLSALGWLGFGVMWVLQAVVFWRGMEAIKKFIDFCGPAVYLVMFLLAAYLVWKAGWSNLDFNLAEGGKTLTGWPAWQETIIAIALVVSYFSGPMLNYGDFARYGTTFGAVKKGNFLGLPVNFLVFAILVVVTAAATRPVFGEILTDPVETVARLDNTFAIVLGALTFMIATIGINIVANFVSPAFDFSNVAPQKISWRAGGMIAAIGSVLITPWNLYNSPDTIHYTLDVLGAFIGPLYGVLIADYYLVKRQTVVVDDLYTMRRDGTYHYVKGYNPVAIVATAVAAVIGVLVVFLASADVAAFSWFIGAGIAFALYLGLKSQIPVHAPATVPAASPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI44</accession>
    <name>A0A011AI44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851085.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2752"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="15796" checksum="312EFE5D39550D12" modified="2014-06-11" version="1">MDELDRAIVAALLRDGRATYQQVGTQVGLSAPAVKRRVDQLRHRGAIAGFTAIVDPASLGWDTEAYVELSYQGNVSPARLRADLEAIPEVVGVRTITGDADALVHVMAANIAGVESTVERMRALPQVDRTRTTIVMSRLFERPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIP8</accession>
    <name>A0A011AIP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851353.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2971"/>
    <dbReference type="HOGENOM" id="CLU_035311_1_1_11"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="43114" checksum="A1928560858647B7" modified="2014-06-11" version="1">MTAGPTTEDLLRALAPQVLAAVVRRYGHFDAAEDATQEALLAAALQWPPEGRPDDPKAWLIRVAARRLTDILRSEQARKAREARALPDDPGEARDSDDTLILLFLACHPSLPVASQIALTLRAVGGLTTAEIARAFLVPESTMTRRITRAKQRIKDSGLPFALPADQQSRLPAVLHVLYLVFTEGYATTAGPALHRVELTAEAIRLTRLLHRALPGDAEVGGLLALMLLTDARRPARTAPDGSLVPMSEQDRRRWDAGRVAEGVAVLESALPRGPVGPYQVQAAIAALHDEAPSAEATDWPQILALYEVLLGMADNPVVALNHAVAVAMVHGPEAGLRLVGRLVDDGRLAADHRVAAVRGHLLERAGDPVAARAAYEEAAARTASLPQQRYLRAQAARLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIU2</accession>
    <name>A0A011AIU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851442.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3020"/>
    <dbReference type="HOGENOM" id="CLU_2552077_0_0_11"/>
    <dbReference type="OrthoDB" id="1989751at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="82" mass="9010" checksum="31F7DC2BC3E83494" modified="2014-06-11" version="1">MATFIDVHSGFVGVTAEQLKEAHEADLAIEADEGVHFERAWLDPESGKVFCLAHGPSKEAIMRVHERAGHPTAEVYEVPIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ44</accession>
    <name>A0A011AJ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851574.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3133"/>
    <dbReference type="HOGENOM" id="CLU_073327_1_0_11"/>
    <dbReference type="OrthoDB" id="1598464at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="140"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="27091" checksum="405F8D7379EE0641" modified="2014-06-11" version="1">MTTTKNVVLTAAGELFGDKDATAVDRWVSPGYVQHSSLAADGPAGIRGLVENLPDGFRYDLHRVVADGDLVALHGTYHGFGPDPLVAFDIFRVVDGKLAEHWDALTPVVAETVSGRSQTDGPTEVTDLDQTDANRELVAGFVENVLKGGKVDLLTEYLSTESYAQHNVGIGDDLDGLGSALQALADQGIAMVYDTVHRVIAEGNFVLTVSEGTFGPTRTAFYDLFRVDAGRIVEHWDVTPEIPATLPHGNGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ57</accession>
    <name>A0A011AJ57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349421_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="742"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="806" mass="87955" checksum="6B4565585FFEE6B0" modified="2014-06-11" version="1">MSVPDDALNALLRDLTDGRGRVLVVPPDDDLRPMAQAGRDAGLLVVDLLPDPQLRAFALGPLIRGLRRVGHPPGVPLMGAAGLPVRTSRRLVRAIRRQVHELDGVLLVAHDEESLDAVTRQWLDTAAHAEDDSPAWIVRTSAGRSELPSGHIEQLDSRELLIARLLAASDFALTADELAELSDETPRTCLSAADALSECRIAAVHDGRYVLRNAYHREVLNAELPPSIRSALERGALRLARRRTGTTTLSAERAMSSARPRDSVAISILTEAMDELVDVEPEAAADYGNAAVALFTDPDEQLTDLAWRLLPLLWQTSRVDEARLLAKRVFAESGRAEVEAQVLLWLARLEGTPQRALELATTALAIPGVPLTIRARLHGVRMRCLSTLGRVHDVDAQLPAALAEARASGDDEALSRLQTCDAIRHFYRGEYTRSASLTALADATWRRSGAPTAEWMPEMIWSPHLTTVLGDPDEGLRRVHGLLDDLATADQPLATQFLHGERALAHLALGHLDDAQDAAVLAATQSQREWGVHDRLQAIAFSVRLKVALHQGALAEFDELRAVLDRSHVEAGSEAEGRRAWWYFLLDDAQGSIAPDRRSIDPDTLSPLPWLDPADEVLIGRALRINGYERAGQDLVDRAAARLDGSGNHVLAVTVADHLHGVVRVDASSLERARHGWHLLGRPLLEAAALSDHGAVLLGAGDTAGAALMEEAHGRLTALGAQRDAWRIRWHLGLHGHVIVPERTGAPTLTPTERRIVDSAARGGSVRRIASELGLSPHTVTTHLRHVYTKLDIRSRKELNEWVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALL0</accession>
    <name>A0A011ALL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_4002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3976"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="350"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="621" mass="66172" checksum="C7A444FFCF85630E" modified="2014-06-11" version="1">MPADGAGARRTLGNAGRAIRLGMRASRPWLIGDVAAMLVAAVVPVATVWLLKTVLDAVAGGRGLAAATPAVAGLVLTGLAAAALPALSDYSHQEIGRRVGRRAQSEIYTAMARLQGLGRLEDPVFHDRLRMAQAAGRSSPGQVINGVLGTGQLAITCGGLVVVLATISPPLAAVNLLGLVPALLAEIRLSRVRADMVWRISPHERREYFYAELQSSLPAAKEMRLLGLSELFRQRMLDQLAVSDEHRRRVDGRQVRAQLGLSVLSAGVLAGGLVWAVGAATGGRLSVGDVAALVAGIAALQGTLASLVGRVSSMHHALLMFDHFRAVLEAEPDLPAAADPRPVPALRRGIELRDVWFRYAPDQDWVLRGVNLHIPHGTSVGLVGVNGAGKSTVVKLLCRFYDPDRGAVLWDGIDLRELDVAALRARIGALFQDYMSYDLSAAENVGLGDVAALDDEERIRAAARRAGIDAALDGLPHGYRTMLSRTFSADPDDREDTDDREEAGATTGALLSGGQWQRLALARTFLRDRRDLLVLDEPSSGLDAGAEYAVHHGLREHRAGATSLLISHRLGAIRDADCIVVLSGGVVAERGTHRQLLATGGTYADLFRMQADGYRDEELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALT3</accession>
    <name>A0A011ALT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852960.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4077"/>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_11"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="80"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="32230" checksum="02DC56CD59BB9C99" modified="2014-06-11" version="1">MGFSNRVTRALGVDVPILSAPMGWVARPELVAAVSNAGGMGLVPGSLPLEEVRGDIRRVRDLTDKPFGINVPILVARDPRVVDMIVEERVGFVTTSAGPPARYTPLLKDAGLTVYHVVPSLRAALKAVDAGVDGLIVEGNEGAGFKNPREVSTMVLVPLVAQRCGLPVIAAGGVADGRSLAAAFCLGAEGAQMGTRMLASAESAVHDNLKQAVLAATETDTVLLDGALGRPMRVLRTDLVDSLLDLPDPDAFARLAHVTTLYHEGDLAASLAQLGQVAGRVDEILPVAEIFRRTLKEFDEVVGGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFZ8</accession>
    <name>A0A010YFZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847631.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.171"/>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="171" mass="19395" checksum="C31174182723366F" modified="2014-06-11" version="1">MDAHAQVAFRDYVSGRRAALLRTAYLLTGDRGQAEDLLQTALVKTYVSWDRIRDKNAVDAYVRQVMATTAVSWWRRRWRGERPSDEVPDARHDADPAADHAERDAMWRLLGRLTAKQRAVLVLRFYEDLSEAQIARTLGMSAGSVKSHASRALAAMRMHLDLPEPTRGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH61</accession>
    <name>A0A010YH61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725652.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.642"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="27466" checksum="1B7CB0F603AD160D" modified="2014-06-11" version="1">MTATVLTGTDLERAYGKTPALRGVSCAVRAGEIVAITGPSGSGKSTLLLCLAGVLVPDAGTVTYDGRRIDTLPEGERSRLRRTELGVLFQFGQLVPELPVAENVALPLLLSGARRKAALATATEWLDRFGVADLAARYPGELSGGQRQRAAVARALVTDPRVLFADEPTGALDSLAGEQLLTQLTRVARENGTAVLIVTHEAQVAAYAQREIALWDGSVVDDGLTDAPTAGARPGSRLVAGDEPQPVATFDESDAPLTDQGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHC2</accession>
    <name>A0A010YHC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1812546_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458843" evidence="2">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="16949" checksum="09856DF59718798C" modified="2014-06-11" version="1">MRDRTKRFAVAVAGLAIAAGTVLASAPAADAATATGRTTVTAAHDRDDHRWGRDRDDRRWGRDHDDRRWGRGHGEHRRHWKKHWKKRSHWEGRRHHRHQWRDHGRYDSYHEAHLIGQRYRGSSWESFRCERSGSRWVLRVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIR6</accession>
    <name>A0A010YIR6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDGLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848926.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1185"/>
    <dbReference type="HOGENOM" id="CLU_137910_0_1_11"/>
    <dbReference type="OrthoDB" id="2022748at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457877" description="PDGLE domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="7">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="12070" checksum="573FF8F356FEED5C" modified="2014-06-11" version="1">MSGRRVKLAVFLGLGLLVALLLAGVVSSAASSKPDGLDATAREGCTFNADDEITGGDCLAKSAKDHDLADSPLADYGIRGIDNPFVSTGLSGVAGVLLVGAIGGGLFWVLRRRDPAGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ05</accession>
    <name>A0A010YJ05_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1256"/>
    <dbReference type="HOGENOM" id="CLU_056696_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="30483" checksum="88395AEC7E1366C7" modified="2014-06-11" version="1">MTRMLERAPNLAILYPRALVKRGGGHELPDTRLGLRDVAVERERLTEYHRVCGFGPSDTLPGTYPQVLAFPLAIALMSERAFPFPLPGIVHIGNTITQRRPIAATERLTFEVRTGNLRPHRRGRQFDVVTEARVGDEPVWDSTATYLRRGAGTGAAAPEPGEVLPTTAVWRVPGNVGRRYARASGDRNPIHLHPLTAKLFGFPRAIAHGMWMKARCLAAIEGRLPEAWTAEVRFAKPLLLPSTVDFGVRGRDFSVASGGRPHLTGRAVPAPGNATPHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJA0</accession>
    <name>A0A010YJA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1324"/>
    <dbReference type="HOGENOM" id="CLU_039404_3_0_11"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015608243" evidence="4">
        <location>
            <begin position="38"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="74"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="43123" checksum="AB5A0607C3928378" modified="2014-06-11" version="1">MRAVRTSRQHLVERVGVAALALGLLAACSSGQEVATGKFSPAANAVKSPAAAPTTLALSKPANKATKVLTSSVLTFATNGTVDAVTLTGPDGKPVAGNVASDKKSWVPARQLAYSTTYKVTATASQKGQTATTTSTFSTMAKPGSITGADLYVNDGDTVGIGLPIVVEFTNSIPKAQRAAVERRLFVTSTPAVEGSWHWFGGSEIHYRPREYWPTGTKVSVRLGIGGLPMGNGNYGKRDRFATFTVGRAITSKVVNKDKTMYVYKDGKLIRKFPISLGKRSTPTSSGKMVAMEKAYEKTFDSGTFGLPADSPGGYRQKVYYDVRFTWGGEFVHAAPWSTGSQGNTNVSHGCVNASTANASWFYELTLKGDPIEVVGTETHVDKGNGWTDWEMTWEQYKAGSAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJI6</accession>
    <name>A0A010YJI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849254.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1447"/>
    <dbReference type="HOGENOM" id="CLU_047251_4_0_11"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29310" checksum="43EB2A0BEF61B3D7" modified="2014-06-11" version="1">MGRTVGFVLGGGGVLGAVEVGMVRALYEAGIHPDLVVGTSIGALNGVVIAAVPPQEAEERLTELWSSTAAKDVFRANVARQVGQLVRSGTHAHTAQPLRALLAPLKDLTFEDLPTTFQCCAASIERAAERWFSEGPLIDAVLASCAVPGLLPPVKIDGEHYLDGGLVNSIPVSRAIELGADQVFVLQVGRIERPLQVPTRPWEVAMVSFEIARRHRFARDMASLPTNIEVHVLPTGLSSDTSGPLAYRSFNRIEPRIESAYRASAAYLVESGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK62</accession>
    <name>A0A010YK62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849589.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1680"/>
    <dbReference type="HOGENOM" id="CLU_526432_0_0_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="358"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="519" mass="56028" checksum="133C0711218A3698" modified="2014-06-11" version="1">MGFSWRASSDRSAQPQAELAEAQADVQALTAIMRAVEQARTPNEAIGAALTLIRELFGWAYGSYWQLDPSGHELRFAQESGSVNDEFRKVTLEAAFAEGVGLSGRAWKARDLVFVPNIADLSDCVRAPAAARAGVRSGVCFPLMEGDHVVGTMDFFATEELQPSAGRLTVLRAVGNLVSRALAHLQEAIRQEKAAQDVEAVSHVIRELTQATSRDQALRTALETIRQYFDWQYGSFWQLDQDQQVLRFAIESGDAGPEFREVTRQASFAKGVGLSGRTWARGDLYFVEDLGEMTDCVRRPAAQAAGVKSGVCLPVRVGGEIVGTMDFFATRTLIMYPGREAALRNTAFLVGSALERFASAEQLQNAGRELLESIAEVERNVTAAATVAERSEHLADEANQQVAVLGQASAEINEVVRAIQSIAAQTKLLALNATIEAARAGESGKGFAVVAGEVKELSSETERATTDVSSKVDTIQARVDEVTASLAEIHTAVEEINQTQGLIRGVLTEQVAVTRAILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKR3</accession>
    <name>A0A010YKR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase, glutamine-hydrolyzing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849881.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1858"/>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_11"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017535">
        <property type="entry name" value="Asparagine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03104">
        <property type="entry name" value="trio_amidotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="591" mass="64977" checksum="3DA2BE0432111B51" modified="2014-06-11" version="1">MCGFGGEFRLDGRAADVDAVARMVPSLIDRGPDSGGYWSKGPLALAHRRLQIIDLSEAGAQPMVDEELGLVLVFNGIIYNYRELRDELKAAGYRFFSTSDTEVVLKAYHRWGERCVEKFLGMFAFVISDWESGRLVMARDRLGIKPLYLSETNGRLRFASTLPALVAAGDLDTSVDPVALHHYLTFHSVVPAPRTILNGVRKLPPATIRVIEPDGTTDEILYWKPEHTRGTELTDDEWRERTLAALRLAVERRMVADVPVGVLLSGGLDSSFVVALLAESGQTGLQTFSIGFEDAGGESGNEFVYSDLIAERFGTDHHQIRIETRNMVPAVDAAIGAMSEPMVSHDCVAFYLLSEQVAKHVKVVQSGQGADEVFAGYDWYPPLSDVPRRDALDAYRNVFFDRGHDALNDLLQPDWRLATDVSKAFVQAHFAVPGAEETIDAALRLDSQIMLVDDPVKRVDNMTMAWGLEARVPFLDHELVELAAACPPRLKLASGGKGILKAAARGVVPDEVIDRTKGYFPVPAIRHLSGPLLEQVADALTSDAARQRGIFDRGQVSALLDKPNETRTTLGSNALWQLGLLEMWLQTKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL38</accession>
    <name>A0A010YL38_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2010"/>
    <dbReference type="HOGENOM" id="CLU_136151_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16033" checksum="05971D46D2A0CFFD" modified="2014-06-11" version="1">MAPTGDDLQQIAEQVWASYLDTDGEKPLIPLPPDKLSKDVVAGVAVSGAWHGLVLVACSDVASKEAAAALLGMESDDVTEGDVDDALGELANVIGGNVKSLLPEPCTLGLPEVHNNADGDPWLVGDEICRFEATWLGEPMEVSVLEKPQGGGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLS5</accession>
    <name>A0A010YLS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotide-binding protein containing TIR-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570027.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2248"/>
    <dbReference type="HOGENOM" id="CLU_575848_0_0_11"/>
    <dbReference type="OrthoDB" id="1508541at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019302">
        <property type="entry name" value="TIR-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10137">
        <property type="entry name" value="TIR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR-like" evidence="1">
        <location>
            <begin position="301"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="474" mass="51573" checksum="56845658E02A5CD8" modified="2014-06-11" version="1">MTNPAEPELVVHVFAPVDGPRAAEGYAAVRELWRRCRTELGMTSALSGSGPSTDLPATLDELPDLTAQKAPDRLYQAILRRFPTSLSLSVLLSPGDAGGWSDLEREWAGVAGSPSDALIGVAYLYLGKVSGLDGVATTELDGPEDRSERRFQVLAGPADDERLSAWTWSDGTTAMPPFARYLRHAASVRYQLRAWQAADEMRRVQERLDRGAPLAEARADLAFWMAAVPDLDRNLEHAAADMRQVPGVDPAVAEDDFGLIEWFRQGLADDLAHLRGVDDRARALSALPSKEPATVTNARDVFVIHGRDEEARRALWSFLQAIDLHPLDWEDVVRRTGSAAPYMGEVLEQAFRDNQAAIVLLTPDDGAYLHPDLQGAHEPHHERVATGQARPNVLLEAGMALALQRERTIVVEIGALRPVSDMGGLNVIKFDGTVRSLQKIAGRLAGAGCAVNTGGTDWLDVSRLANLAAYSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMD8</accession>
    <name>A0A010YMD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2465"/>
    <dbReference type="HOGENOM" id="CLU_018297_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="597" mass="62568" checksum="A2358E44840650BF" modified="2014-06-11" version="1">MGLGSLCHVLEEIRITGLGVIEDATLELVDGFTVVTGETGAGKTMVVAGLGLLFGGRADAGRVRRGSGRALVEGRLRFEPDDPAQKLVLDRVAEAGAAPDEDGTLLLARSVAAEGRSRAHVGGRTVPVGLLGELAEQMLAVHGQSDQLRLLSAAEQRAALDRYAGEEVTALREQTSRQYQAWRKTVGELTDRTNRAHERAQEADALRFGLTEIEAVNPLPGEDEELKAESQRLEHAEELRIAAYTAHQALAGDPTAEQESADVAALLGVVRRSLSAVAGHDAVLADAGRRADELAALCGELGTELASYTENLDADPARLAAVHERRAQLAGLTRKYSDSIDGVLAWAEQAAGKLADLDTSEEALDALRARRDELAAALAKSAVALSKARQAAATRFGEQVTAELTGLAMPHARVVAAVSQKDASEAAPSVEIDGRRLAVGPEGIDDVELRLASHPGAPELALHRGASGGELSRVMLAIEVVFAGAGGPPTMVFDEVDAGVGGRAAVEIGKRLARLARTHQVLVVTHLPQVAAFADHHVVVVKDSDGSVTTSGLRSLSATERPRELARMLAGLDDSDLGLAHAEELLAVAQAEKDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YME8</accession>
    <name>A0A010YME8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2475"/>
    <dbReference type="HOGENOM" id="CLU_062658_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21969" checksum="A93BA48E4E858D81" modified="2014-06-11" version="1">MTYELVSRTPQFTSGRVIDVVTDEVTMPGGNTRLRDWIIHPGAVGVVALDADHRVLLVRQYRHPVGRELWELPAGLLDVDGEPAVVSAARELAEEADLRAGRYDTLVDLLTTPGASNEAIRIYLAREISPVPEAERYTRFDEEAGMTTAWFGLDEAVDMVLAGQIENAAAGAGVLAAFAAHARNWKGLRGPDAPWAARPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMM8</accession>
    <name>A0A010YMM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycofactocin system FadH/OYE family oxidoreductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850816.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2558"/>
    <dbReference type="HOGENOM" id="CLU_012153_1_2_11"/>
    <dbReference type="OrthoDB" id="1308229at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023987">
        <property type="entry name" value="CHP03977_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03997">
        <property type="entry name" value="mycofact_OYE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="367"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="632" mass="66515" checksum="BB62674CA57E8FDF" modified="2014-06-11" version="1">MPTLATGLRLGRLTLRNRVVFSAHLTNFAVDGAVTDQHVAYYAARAAGGAGLIVTEEHTVHPSDRPYQKMIRGYRRQPGYRALTTAVHTAGAAVFAQLNHNGGQSSGLYTRQPVLAPSPVPDALFREVPAALTTTQIAEIVAGYAATAARCVEGGFDGVELQASHSSLIRQFLSGATNHRTDVYRERFRFLGEVIAAVRAAIGPSPVLGVRLGGDEMIEAGITVDEAVATARAVEATGQVDYLNTSIGVATETLFLIQASMRVPPRYALHIPAALRAAVSLPVVGVGRFKSLAQAEKALQEGAADLIGAVRAQIADPDWARGGARTCLSCNQECVGRVGFNRWIGCVVNPAAGHEAVPVAAPRRRQRVVVVGGGPAGMRAAVTAAERGHAVTLYERSEQLGGVVPLAASVPSRAEFAELTRSLAAAVSRAGVAVRLGVAATAETLLTVAPDAVVLATGARPVRPPWGASPRVVDVRLVLSGRVAPSGNVLVYDELGFHEGTSVAELLADRGCRVEIATPGMIVGQDLGPTLDLELWTIAAHARGVVCTPDVTVSAAEDEGERLRVVLAHHPTGTRRTRTVDWVVTSVHPRADDTLWHELRGAPFPVHRIGDCLAPRRAHAAVLEGERVAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN76</accession>
    <name>A0A010YN76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2725"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="23800" checksum="15DA18A4BC88CE51" modified="2014-06-11" version="1">MTRADAFHIERNPALIRSQVLENLRQAILDRRLAPGQRLIERELVELTGVSRTSVREALRELAAEGLVTAIPNRGMVVTSVSAEEARQLYQVRSALEALAGRLFVENAGPAHRRALVRAVEKIDRLAAKGAPLLAAKDAFYDVLFEGGGNDALRAVVNGLHARVSVLRSLSMSVPGRLEHSVRELHAIVDAALAGDADATAAACAAHVEAAGRAGLTALAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP15</accession>
    <name>A0A010YP15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851403.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3004"/>
    <dbReference type="HOGENOM" id="CLU_153068_0_0_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="14994" checksum="AA76F4C8D2E6AE49" modified="2014-06-11" version="1">MLTAEDLEFLARPLLGFLTVAAGPTPPQPRPVWFEAADDGTVQLFTGPASVKVKRLSRDPRASIVVAAPVEERERWVSVAGRVTVEADGAHELAARLAAKYWDLDDPARAEDLKNLLAEEQVRLVIHPDAVHRFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRG3</accession>
    <name>A0A010YRG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852706.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169119_0_0_11"/>
    <dbReference type="OrthoDB" id="1228102at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="25548" checksum="71D04D730A3D224F" modified="2014-06-11" version="1">MRRTGIALLVALSFVLAGCDGQLPVVTRVVAGAEPSASSTGSAPPVAPTVEPGRHLTAEEARAALPDESSLPGRNWESPPSREDPVAPTKPEECGQVGHRGPLVQAGVPDVLETVTYRTKDPQALDAKFFIASWPNVADRLDLDQTAALVDRCRSFVAYDGVGKGYPVTLDRLTPPPVGEKQFAVRYTVTGDGYLTITWVVIGHTMVQLSVLHDRADDQATPFRPVFESIVNDRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRH3</accession>
    <name>A0A010YRH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21492" checksum="5B278CA34C57FA27" modified="2014-06-11" version="1">MIRVAIIDNDKLVPAGLRALLAEAGDIRVEHAATTVNAHLAAAPPADVVLLDLRLEDGTDAAANVARLRRAGVRVLVISVHGERRDVRATVRAGAGGYLVKDDDAGKLADAIRSVHHGQPALTAELMSLINDDPPELSPQEERALYLYGTGSTLAATARRMGVTIPTVRSYLTRIRAKWAAVDQPVDDVRTLISEYRPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRN3</accession>
    <name>A0A010YRN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4046"/>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="111" mass="12127" checksum="A1F6683EACF73663" modified="2014-06-11" version="1">MAGNTCVVDGFTVIAEPTRRAIVDRLRVAESDVGALVGALELSQSLVSKHLRVLRDAGVVEAQVVGKRRVYRLAADPLPDVVAWVQPYLRTWASSFDRLANALDEEDAHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW03</accession>
    <name>A0A010YW03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.326"/>
    <dbReference type="HOGENOM" id="CLU_955510_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="291" mass="30552" checksum="AF5F32803C258437" modified="2014-06-11" version="1">MQADAAYARLREAIVDGQYPAGARLTEVEIAETLGMSRTPVREALRRLAGDGLVRASDRGVIVDLMDEEEAWHARTVRAALDVLVAELAARRQKAGEVSPAALRAAEEAAASARTYLERGDTDEAYRHDQRLHRQIAEIAGNPVALQMLDRLADRLEVARLAAASRAERAKNIEKKVDGIHLVTKVPAAVGAGFDGDVRSGLDLNGHAVNGANGSHGAGADKPGAEGATGSASMKKNGTRSGGTVGDDGMGRLAVPVLSPDLAEEHRRLLDAIAAGQPAAAWLAAREHAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW21</accession>
    <name>A0A010YW21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1737 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.351"/>
    <dbReference type="HOGENOM" id="CLU_186571_0_0_11"/>
    <dbReference type="OrthoDB" id="2052246at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013619">
        <property type="entry name" value="DUF1737"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08410">
        <property type="entry name" value="DUF1737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1737" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="67" mass="7423" checksum="C40FB709223120C3" modified="2014-06-11" version="1">MDHTTERLRYILLTAPNGDELAARVSEALDEGYELYGSPAITFDGEHMLVAQAVVLPAYAAGRYRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW51</accession>
    <name>A0A010YW51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ORF">CryarDRAFT_0403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569610.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.387"/>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_11"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="203" mass="22193" checksum="75DCD73E281D0825" modified="2014-06-11" version="1">MTPAGEGGTSAAEAVDLPRIQRAVREILTAVGEDPDREGLRETPARVARAYAEIFSGLHVDPSTVLTTVFEEDHEELVLVKDIELYSTCEHHLVPFHGVAHVGYIPGEDGRITGLSKLARLVEAYARRPQVQERLTSQIADTLMAKLEPRGVIVVVECEHLCMSMRGVRKPGARTVTSAVRGWFQRSQAARAEAMSLILGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWW1</accession>
    <name>A0A010YWW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848412.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2648398_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="76" mass="8229" checksum="4F4D15F3717F4757" modified="2014-06-11" version="1">MIDHGLLIAATVYTAVLVAAGVAIVLSLAVWAARPPLTEWARHRAATRDLRRTADALQRSSTDDTPRARTPHHAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXA1</accession>
    <name>A0A010YXA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848567.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.823"/>
    <dbReference type="HOGENOM" id="CLU_037628_4_0_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458920" evidence="2">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="54"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="37467" checksum="FBABDD31FF56ED24" modified="2014-06-11" version="1">MLFATSALATLLAVASCSQSDSTESDASSSPSTGPTASAPLPSPFNADPVTVALVRQSGAGDYFEAWGQGAQKQAAAANIKLTVTDARNDNAKQASDLQQAIDSKPAAIIVDHGQTDTIAPLVKKAVAAGIPTIVYDVALPADVTGYINTSQSDESLAQAVLDQMVKDIGQNQKVGLVSATGFAPLDRRGQVWKKVVADNKLQQVFFTGKVTESTATDNIPLVDAALKQHPDVKAIFAPYDEITKGVVQAVKQNNLQDKVKVYGIDISNADLEVMTAAGSPWVATAATDPGQIGAAVVRTISLKLAGQFNESSVQFPGVLITQQVLKEKSITTVGDVVKAEPKLKLDTVSVADWLPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXH4</accession>
    <name>A0A010YXH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200554_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="55" mass="6412" checksum="94D0FF14A9612A28" modified="2014-06-11" version="1">MAWDDEREVPMIDDTDIVVLPDQTTDDTDSTDWRAATSGKLRDLELIENRPPHWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXM6</accession>
    <name>A0A010YXM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569762.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.989"/>
    <dbReference type="HOGENOM" id="CLU_038356_3_0_11"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458206" evidence="2">
        <location>
            <begin position="16"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="3">
        <location>
            <begin position="143"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="345" mass="36283" checksum="3CF25490F4592DFD" modified="2014-06-11" version="1">MVVRLIVLVTSPRLPAGLLTADGWDAVRSHPVLAAGPSPLSDAVRAAGVPVAEVGSDPGSALTALRRAAETAPSEAGAAVWLAGANDPLPAVLAERLAADPALDYQVEVLYGSWDPPGARLLDVASVMDRLRSPGGCPWDAEQTHESLRPYLLEEAYEAYDALLDGDLDALREELGDVLLQVAFHARVASEDPDEGFDIDDVAGDLVAKLVRRHPHVFADRAVSGADEVHTNWEAIKKAEKKRDSALDGVAQSQPALSLAAKYLSRARRAGVAVPPPALPPSVTAPATADALGDLLFAFVAAGDEAGLDAEAALRAAARRYAEDVRDAERRDVEARDGRGRSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY54</accession>
    <name>A0A010YY54_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848925.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1183"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_11"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17041" checksum="6EEDDD8476A8C47E" modified="2014-06-11" version="1">MTAAPRLSPGDPAPDFELSDDHGNPVHLADLRGQRVILYAYPSAMTPGCTKQACDFRDSLDSLKAAGLAVIGISPDKPEKLAKFREKESLTFPLVSDPDKSVLTSYGAFGEKTMYGKTVTGVIRSTFVIDADGKIEKAQYNVKATGHVAKLRRDLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYQ0</accession>
    <name>A0A010YYQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849192.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988910_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13095" checksum="5A1BCAFCFC220E75" modified="2014-06-11" version="1">MRDHVIVKNERRALLAYSSSTQPADGPEFSHFLRGAAAALDWATNTVANAPVGPGSGPADAALIAAEIELCDVLLAGSVSALTPVRKDPHYVNGVEHALRWLLELEAEPPVPLIEDDAPVAVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYS5</accession>
    <name>A0A010YYS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569868.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1420"/>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_11"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="30817" checksum="E8155ABC65F26F71" modified="2014-06-11" version="1">MRVAVCQLNSRDDRAANLAEARRLLEQAAAAGADFAVLPEFVDYLGRRRGEPEPETVDGEFAQFFSRAARELELTVLAGSFRERAEDGERAYNTSLVFDRSGRRVAAYRKIHLYDVEIPGRVSYHESKTIAPGEELVVADVEGTPVGLSICYDLRFPELYRALAVAGARVLVVPAAFMAHTGRDHWEVLLRARAIENQCYVVAAGQIGDHEPGRTCFGRSMVIDPWGTVVAQAPDVVGVVTADLDLGRLEDVRAELPSLANRRLPDQDGVKVQVSPSATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYW1</accession>
    <name>A0A010YYW1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">CryarDRAFT_1481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849268.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1454"/>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_11"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="85" mass="8895" checksum="0483E1BC30D739FA" modified="2014-06-11" version="1">MAHKKGASSSRNGRDSAAQRLGVKRFGGQVVKAGEIIVRQRGTHFHPGDLVGRGGDDTLFALAPGAVTFGNKRGRKTISIVPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZC8</accession>
    <name>A0A010YZC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861325.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1624"/>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_11"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="109" mass="11784" checksum="134DF266522D06C4" modified="2014-06-11" version="1">MDTTQLLKGVLDLAVLAVIRDADGYGYDVLRRLRGAGLADVGDASVYGTLRRLYQAGCLTSYVVPSEEGPHRKYYGITDAGRLQLAESTKIWAGFARTMDDLLTGEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z022</accession>
    <name>A0A010Z022_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B12-binding domain/radical SAM domain protein, MJ_1487 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849861.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1841"/>
    <dbReference type="HOGENOM" id="CLU_042889_0_0_11"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023980">
        <property type="entry name" value="CHP04013_B12-bd/rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04013">
        <property type="entry name" value="B12_SAM_MJ_1487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="168"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="433" mass="46666" checksum="8D2D756BF3B25510" modified="2014-06-11" version="1">MSVAVVLRYRKAVTYGHHALLGALEAEPPETPFTVAFATSPEQTAAAVGSALDEADRVLVLWSFYSPDADALAVELAAVRALVDDERVLHVAGGVHATAEPQQVLDAGWDVAAIGEGETTIVRLVDAVGTGAPLTGVRGLAVRDSDGVALRTGPAITRELDAFGSFSLKYHKYGPIELTRGCIYACKFCQTPFMFSARFRHRSVENVRWHVRAMVADGLKDVRFTTPTSLSYGTQTEEPDLDAVEELLGTVRAELPPHGRLFFGSFPSEVRPEHVTPGAMRMLRRYVSNDNIIIGAQSGSDRMLAASRRGHGAGPVLDAVRIAAAEGFRPNVDFLFGMPGEDAEDAEASLRLAEAVAALGGRVHAHTFMPLPGTPWRDAEPAFVSADTISTFDQLAASGALYGHWRRQAEHASRLAETAKAYPRRAPRRRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z038</accession>
    <name>A0A010Z038_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849888.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1866"/>
    <dbReference type="HOGENOM" id="CLU_018808_15_0_11"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="547" mass="58423" checksum="B74E3C6A2B32EAAD" modified="2014-06-11" version="1">MDVKVTELVIFCILFALVSVLGFVASRWRRPESMEHLDEWGLGGRNFGGWITWFLLGGDLYTAYTFVAVPALMYGAGALGFYALPYTVVLYPIVLLPLVRLWSVSHVHGFVTPADFVRARFGSSTLALLVAITGFVATMPYIALQLVGIEAVLKAMGVEGKWPITIAFLILAIYTYNSGLRAPALIAFVKDTLIYLTVIVAVIVIPAKLGGWDAIFEAAGAKFSAPAAQAAGSGLLLNANNQLNYITLAFGSALALFLYPHSLTGVLAARSRDTVKRNMAALPAYSFVLGLLALLGLMAIAAKIVPVGADPEAGVAGDRNTVVPLLFDWAFPSWFTGIAHAAVGIGALVPAAVMSIAAANLFTRNIYTEYIRPSASPAEEARVSKLASLAVKFVAVILVLGLDTQYSIDLQLIGGVIILQTLPAVALGVFTRWFHKWGLVAGWAAGMAAGFWMLWTIPNPATKREHFGGSAFKLSELGLDTKWTIYTGFLAVAVNLIVAMLVTWGLRAGKVPDGEDLTKPSDYTAEQGDPKVHDIPELVADGKTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z046</accession>
    <name>A0A010Z046_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849904.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1876"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_11"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="23564" checksum="E149C61BE71ED3F0" modified="2014-06-11" version="1">MSNSTVLILGASRGLGLGMAAEFRARGWNVIGTVRNGSPDALADLDVTVETLDITSPDQLDALRRRLDGQTIDLLFVNAGVASTDAPAASVSTEEFVDVMVTNVLSPMRAIEALGDLVPPTGTIAVMSSRQGSITLNDNAGYDVYRASKSALNQLMRCYAVRHEGDGRTLLLVNPGHVRTELGGPGAVRTVAEAVPPVVDTVEKRAGSGGFHFVDYTDQVVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0J8</accession>
    <name>A0A010Z0J8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_2073</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850120.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2038"/>
    <dbReference type="HOGENOM" id="CLU_028108_2_0_11"/>
    <dbReference type="OrthoDB" id="167675at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="46"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="253"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="537" mass="56572" checksum="CC9CD7F05C531033" modified="2014-06-11" version="1">MVDRLKRALGRGVEGFKAFSAGQKAVLVVAVLALVVGGYFFASWASKPTMASLFSNLSATDASAIVEKLGAANVEYELADGGATIMVPRDQVYDLRLQMAGQGLPAGEDTGYSLLDKQGVTTSEFMQHVSYQRALEGELASTISSIDGVEAATVHLALPQKDVFADDQQRPTASVLVKTAAGKDLTDSQVQAIINLVSSSVEGMDSSDVTLAGADGSVLAKGGQTTTAAGGDSSSKQTEAFEDDMQDSIRTMLEQVVGKGKAAVTVTADLDYDNTQTKTQTYNSDANTQPLAESQKTETFSGNGNAVGGVLGPDNIQVPSGSNGSNNYENSTTTKNNAVNSVTETRNSAPGAIRRMGIAVLLDSNVPASANTAKIQTLVQSAAALDTTRGDSLAVTALPFDESAAKAAAKELAESQAAAKQAQMMGTIKSGAAIGLIALLMLIAAFVSRKNRKKQQRTTLTPSERLQLEEMQAALERERMRELEAANSPAAIEAGPTRLGPDKETRQREIAEMVEKQPEEVAQLLRSWLGDRREVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0U0</accession>
    <name>A0A010Z0U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850214.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2124"/>
    <dbReference type="HOGENOM" id="CLU_033716_1_0_11"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="43711" checksum="FA67F0DF4828AAA6" modified="2014-06-11" version="1">MECLRLGPEFFTDPHADYSWIREQRPTSRVITPQGNEVWLVTRYADARAALADPALHKDNAEFHALAEARYGPIPRHEIKNEINSHMLAADPPDHTRLRKLVGKAFTARAIAALRPRIEEIAASLLDEMEAGPDRVDLLDAYAFPLPITVICELLGVSMGDRDDFRAWSNTLLQSADREAHTAAASSIAAYLTALVDERRAHPTDDMLGAIVAASAESDRLSRNEAISMAFLLLIAGHETTVNLIGTGTYALLRDPAQFAALRSDPALVPNAIEEFLRWDGPVHLATLRFTASPTVIGGVRIPAGEVVLVSLTSANRDPERWPDAETLDVRRPATSHLAFGHGIHHCLGAPLARLEGEVAFTALLSRFPALALDADPSTLTWRPSTLIRGLDRLPVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1V1</accession>
    <name>A0A010Z1V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xerD</name>
        <name evidence="16" type="ORF">CryarDRAFT_2517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850707.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2478"/>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_11"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="15">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="14">
        <location>
            <begin position="114"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EXG81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="32783" checksum="E282DA5EF3FEC5CA" modified="2014-06-11" version="1">MEALERAVRGYLDHLAVERGLARNTLLAYRRDLTRYLGFLEARGIDGLAGVGERDVGEFLATLRAGDDEHPPLAASSAARAVVAVRGLHRFAVRDGRAGSDPAREVRPPTPPRRLPKALPLADIERLLDATGGGDDEPRAARDRALLELLYGTGARISEAVGLDVDDVPAGERDTVALTGKGDRTRLVPVGSFARSAIDAYLVRGRPALATAGRGTPALFLNARGGRLSRQGAWGILNAAAERAGLAGRVSPHTLRHSFATHLLDGGADVRVVQELLGHSSVATTQIYTLVTAEKLREAYAMAHPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z271</accession>
    <name>A0A010Z271_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2603"/>
    <dbReference type="HOGENOM" id="CLU_000960_2_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="546" mass="56190" checksum="A1AA039FDF606543" modified="2014-06-11" version="1">MTAQTAPRSASGEAMTHRQTLEALSGLLLVLFVAMTSATVVSTALPTIIGALDGSQSQYTWVVTASLLAATATTPIWGKLADLFSKKLLVQIAIGIFLVGSVICGFAQNAGELIAARAFQGLGMGGLQALVQVVMAAMIPPRERGRYNGYLGGVMALATVGGPLLGGLIVDTSWLGWRWCFFIGVPIAIVALVVLQRTLYLAVVKRAGVSIDYPGAILIAGGVSILLIWVTFVGDTFAWVSWPTAAMVGGGVLVLAFATWVESRVKEPVVPLRVIAQRTPALAIVASLSVGMAMFGGAVFLGQYFQIGRGYSPTEAGLLTIPMMAGVLLSSTISGRLITATGTIKPYIVGGTIVLVAGFGVLGTIDHLTSLWLVGVGMFLVGTGVGMSMQNLVLVVQNTVALSDLGAASGAITFFRSLGGTIGVSVLGAVLANKVTTDITAHLRAAGVPASAGGDTSTLDLKSLPPAFQEIVRAAYGDATGHIFLIAAGIAVVGVLAAVALPKVELRTTVDLARADRDPDEVTPLTEVAGGVGVEDGNRTEGVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3L3</accession>
    <name>A0A010Z3L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118707_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="93"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="26174" checksum="A0C2FE0A17346A3E" modified="2014-06-11" version="1">MPTDQKLPRQHAIATIAAAMLITISCGLLATGHVKAATTVNLAGLILAVLRLVQFNHQLVDVTQQLDEAYTDPVTGLAVRRVAEHYLADHTGETLTVALVDVDNMHALNATFTHTGGDEYLAGIAQRLTSTAPEHLVARLGGDEFLIAGPAAPQTLAEALTASFQQPVTVGSTSVPVQASVGIATGFDDPRRALAAADLAMFAAKRNGTGIEFYDPLRDGLPAPTGDRPADRRRDRRPTGSDTPSPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3N6</accession>
    <name>A0A010Z3N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851516.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3100"/>
    <dbReference type="HOGENOM" id="CLU_009097_4_1_11"/>
    <dbReference type="OrthoDB" id="182908at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="440"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="566" mass="60422" checksum="C2570EB0C113960C" modified="2014-06-11" version="1">MKNPAPTIENTPRYVQVGDGYAATLVVTGYPAEVGPAWLDPLLAWPGRLDVVVHLDPLPAPVAATQLRRQRARLESTRRDDAATGRLGDPLTDAAAEDAAELADRVARGESKLFRVGLYLSVHAQSVDELDDAVADVRATAASMLLDTQPATWRQLQGWTTCLPLATDGLNMRRVMDTEALAAMFPLASPDLPAPLPGEPAAAGGVLYGLNPASHGVVWWDRWTQHNANSVVLARSGAGKSYLVKLEILRSLADGVHVSIIDPDNEYLRLVDAVGGVTLALGAEGVRLNPLDIPPGDRRPQARTYRALFLHTLIAVLLGHQPPPTERAALDGAINTAYNNAGITNDPATWRRPAPLLRDVADALTAQDTAAGTTLAARLAPWTTGSFRHLFDGPTTTVPSGQLVCWSTRQLPDELRAPGMLLALDAIWRDVDTPVTAAPRRLVVVDEAWTLLRDGEGARFLARLAKSARKRRAGLAVITQDVGDLLGSELGQIVIANAATQILLRQAPQAIELVADAFGLTGGEARQLLSAGRGQGLLLSGTHRVAFDVVASPREHQLCTGDLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4E0</accession>
    <name>A0A010Z4E0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026152_4_2_11"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="184"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="39504" checksum="3CD524AE47AF77E3" modified="2014-06-11" version="1">MITRNGAQVCAAAAVLATISLVTRYPGVVLLAAGASVSVLVAFLWTARSRRRASVSLVPAVGRVMRGEVVRVAIHVTRRSARGGAFTLVVPCGGAEIVVPVRRGSGRAAAPLEIDVPTDRRGELVIGPPAIAHRDLLGLFDRREQVGEPVAVEVGPRILPVEIGRARGRQNPDAPRQLGGQEGGVNFASLREYQFGDDVRRVHWLASRRRADGTLLIRQNVDPVDPSIEVLLDTDPAAYRGPDASAAFETAVDVSASILDSTRRVGAAATLTVVSGETARTPHAIDELLRTVGLSPGRAVPALRPAGLFTVVTGSGGASDLLTAVPPGRRSVVVRVDVRPADLPVASARWAIVDAADLRSALAGWARLAAAATRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4P3</accession>
    <name>A0A010Z4P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3446"/>
    <dbReference type="HOGENOM" id="CLU_087351_4_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="19705" checksum="ECC5E550EC3B42E5" modified="2014-06-11" version="1">MRFGKLKAEKGSLAPDTVTVEIRRFRPADSAAVADVIERCLREVNSRDYPSDTIELMCAHFTPRQIERLAAERQMFVAVDQDDVVGTVSRDGNKVYTMFVHPRTIGQGIGRHLMVHVEALAAADGYAFMETGASITGHGFYQRLGYLDVRTSETEFGFNYILRKPLPRPDPDAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4T9</accession>
    <name>A0A010Z4T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3497"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="23867" checksum="DADCF8FBC9720357" modified="2014-06-11" version="1">MTGVRVLLADDQDIVRAGLRLMVDNAPDLTVVGEAATGTHAVRMARQTRADVILMDIRMPELDGLAATRRICADPDLAGAKVLILTTFEVDEYIFEALRAGASGFLGKGARPEALIDAIRTVARGESLLSPAATRGLIARYLALEDQPPAPASGVLDGLTEREHEIVALVATGMSNNEIADRLTLSPLTVKTHVNHAMTKLDARDRAQLVVIAYQAGLRGPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5E4</accession>
    <name>A0A010Z5E4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841231_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458948" evidence="1">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="45"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="34524" checksum="44E7FD473833C9E9" modified="2014-06-11" version="1">MVRTGNMTRRVAGLTGLALVALGLVACGDSGDQASGDCRKTYTIGFSHPISEAAFVKALKKEIQGQADTIGCVEMLFDDTQANDLESQRNTVETWVTQRVDAVVVLPVDAKALSPLQKQAQSSKIKWLQYATPGDGVDGYTGFDNVRSGQIVGQAAVDWIKQQQVSGKVTAAISSISALPDVKGRWVEPQKLIPAAGVKVVSLQDCADQTCGLEQAEALLNAHPDLRVYIGANDDAALGALKAFQSRGIDPKSVFIAGQDGNIEALKAVKAGGAYRVSAAIDLVDLAHAIVQNSINAVEGSGETETEAAVIPASLTDPAKLDELIAQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6G1</accession>
    <name>A0A010Z6G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline/Carnitine o-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852932.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4064"/>
    <dbReference type="HOGENOM" id="CLU_013513_4_2_11"/>
    <dbReference type="OrthoDB" id="886915at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="PTHR22589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carn_acyltransf" evidence="6">
        <location>
            <begin position="15"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="576" mass="62901" checksum="49A49223005B1ADF" modified="2014-06-11" version="1">MTRTFANEDHLPRSPLPTLEDSCARFLDWCAPLLTAEQRAATEASVTEFLGGSGRTLHAALEKYDASEGVHSWLDTFWPYRYLGRRDRIALNANFFFLFRDAPLGQVERATALIAGALAFKQAVDAEELPPAVVRGVPQTMEQNKYLFSTTRIPGAVQDTVRGPYGKGWDGPSTARHILVLHRGTIYRLDVVGHTLDEIAAGLRAVLAGGRRTEYPVGHLTTKARAEWAADRRALDPALLDEVESALFCVCLEDLTPASDLEAADQLLHGDSGNRWFDKAVSFVVFADGRAGINVEHCELDGTTILGFTDFVLSYAPDDYAETPQGVPVARPLEFALDDAQRAAVRDAAASFADYAAATATTVLTFTDFGSDRAKSLRMSPDAFLQMTYQLAHRRAKGVTGATYESIGTRQYQWGRTEAMRVVTPEAVAFVDTMEDPAAGDARKRDAFRAAAEAHVRRATECRLGRAPEQHLWELQLIQRRRGAELGVDTEPALFSTPGWLIMRDDYLSTSSAPSTSIDYFGFGSTSSTCIGVGYVLLPDRVAIHLSTPRAVEDGMAAFAAQLGVAVRELTALLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6L4</accession>
    <name>A0A010Z6L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4127"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="23927" checksum="2FF749E8B5B155AF" modified="2014-06-11" version="1">MIRVLLVDDQALIRAGFRMIIDAEPGLEVVGEAADGRAAVDLAYSAMADVVLMDLRMPTMDGIEATRRIGADDRLAGVRVLVLTTFEEDDNVVLALEAGASGFLGKNVDPDDLVAAIRVVADGEALLSPRATRGLVARFIAQRRPEATDHPGLRYLTDREREVLVLVAHGLSNEEVAARLTVSPLTAKTHVNRAMTKLGARDRAQLVVVAYQSGLVRPGDALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK25</accession>
    <name>A0A010ZK25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569520.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.32"/>
    <dbReference type="HOGENOM" id="CLU_025431_0_0_11"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="479" mass="50514" checksum="4977BB776AD69C9B" modified="2014-06-11" version="1">MSLTLRYAAKSDRGLIREGNEDSVYAGPRLLAVADGMGGMAAGEVASNIVVRALEPLDEDVSAHDLVDALRGAIGHANQQLRDAVDANPALEGMGTTLTALLFSGTRLALAHVGDSRAYVLRNSELHQITRDDTYVQMLVDEGRITADEANTHPQRSLLTRALDGREVEPEFSVREARPGDRYLLCSDGLSSVVSMETIEDAMRIDDPAQVANRLIQLALRGGGPDNITVIVADILDDRLADNAPVVGGAAARDRTTSATADTAAGRAALATPPRPTLDDNNYGVEEEDEPVESGGRHRRRTTALLTVLALAALAAGGYAAWHYTQQQYYVGTTEAGHVAIYRGVSGSLAGLEFSTLQSDTDLRVDDLQQVARESVEQTIPAENREDAYTIVDNLRQGQVLPWCHGDATPTPTPSVTPSTTSSASPTPSESTSPNSSATPSSTASASPSAPAATASRPAGEILPAGESDKPGENCRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLM7</accession>
    <name>A0A010ZLM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848306.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008530_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="506" mass="51617" checksum="B950D9263DDC86EC" modified="2014-06-11" version="1">MTPPDGRWQPGPVLAGILVVLASGAVLVLEILSLRLIAPYVGVTLETNTAVIGVALAAIAVGAWAGGAVADRLPPAVLLGPLLLGAGALVFAVTPVVRFVGELVQGADASGVLLVAAAAVFAPAALLSAVPPIVVKARLANLSETGTVVGRLSGLGTVGSIVATFGTGFIAVAMVPTTTILTGLAVLLVVTGLAVAWISRGASRLSPGSKRGLAGPLALALIGAGATAAAPNPCELETVYHCASVSADPDRPDGDGRVLRLDTLRHSYVDLKDPTYLQFEYLKVIGAATDVFRPPGAPVKALHLGGGGLTLPRYLKAVRPGSDSLVYEIDAGVLRIDREQLGLREGDGIRTRVEDARVGLDEQRTDSYDLVVGDAFGGVAVPWHLTTRQVVAQVDRALTPTGMYAVNLIDHGSLAFVKAEVATISAVFPHVALIAETAAFSGAGGNLVVLASASPLPLAALKSALATKAPAMNVVTGGDLSGFIREAKVLTDDFAPVDQLVTPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMH7</accession>
    <name>A0A010ZMH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857169_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="35074" checksum="B993FAA5F5F6851A" modified="2014-06-11" version="1">MTDLGAFARGLSLLSPRDDETYRAMARLFGYDVAPTVPNPESISVERPYIVQDRRIDASEGATAPDTRIPPLDVSASAAGKSPQEAGIPASLTRYEPRLMVEKELRDKLEDGVRLPPVPPLVSSARNIDTLFRPSWQREIIKELATIETFTDEPSVESLVEALATGKAIAALPATTRIDVNPRVRVLIDTAQSMLPFTEDQALFAAALQRVLGKPMVAVERLRNAPQQVSAEGGARWSPAIASLGESLIVVSDLGMTRHLVKQGFTTVYWIDFARSSFAASGLRPVAVVPCSLGLVPDLVRKAFAVIPWDRPTSPGLVGRVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNY9</accession>
    <name>A0A010ZNY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM family uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849260.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1450"/>
    <dbReference type="HOGENOM" id="CLU_011543_3_2_11"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="260"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="642" mass="72229" checksum="8EC5CF4CABA65165" modified="2014-06-11" version="1">MSVQSVFPRLENLLPKVQKPIQYVGGELNSTIKDWDAHPVRWALMYPDAYEVGLPNQGIQILYEILNERPDALAERTYAVWPDLEKLMRENDVPQFTVDAHRPVRAFDVLGVSFATELGYTNLLTALDLAGIPMNSADRTEDHPIVLAGGHAAFNPEPIADFIDAAVLGDGEEAVNEMTDVIRDWKAEGRPGGRDEVLLRLARTEAVYVPRFYDVDYLPDGRIQRVVPNRADVPFRIRKRTTMDLDAWPYPKQPLVPLAETVHERASVEIFRGCTRGCRFCQAGMITRPVRERSITGIGEMVDASLKATGFQEVGLLSLSSADHSEIAEVTKDLADRYEGTSTSLSLPSTRVDAFNIDLANELSRNGRRSGLTFAPEGGSERLRRVINKMVSKDDLIRTVTAAYSAGWTQVKLYFMCGLPTETDEDVLEIAEMAHDVIRAGRQAAGRKDIRCTVSIGGFVPKPHTPFQWAAQEDPDVVDDRLRKLRQAINADRGLGKAIGYRYHDGKPSLIEGLLSRGDRRVGRVIRKVWEEGGRFDGWHEHFSYERWIDAAKTELEPLGVSLAWFTTREREELEVLPWDHLDSGLDKEWLWDDWQDALDSVEQDDCRWTPCFDCGVCPTMDTEIQIGPTGKRLLPLTVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP15</accession>
    <name>A0A010ZP15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849302.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1476"/>
    <dbReference type="HOGENOM" id="CLU_068874_0_0_11"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458033" evidence="1">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="30651" checksum="BDDB5CCA1DE893D7" modified="2014-06-11" version="1">MRKAAVLAVVLVALVTVTIVSVSRLTKLHVPFLSDTCRSYASNDVVRLAPDQLTHAATIVAAAARRDLPERAAAIALATALQESKLRNLDAGDRDSIGLFQQRPSQGWGTPEELSDPRYAAGEFYDHLVRVRGWQKMRLTDAAQAVQRSAHPELYQKWESDATTLAAALLGDEAGAVTCQLRRPPDMSGQPASTALVAELAADLGKLTVNPSVDGDTPILTVAVGGGAKSRLGWQSAHWFVAKAHEFGVRRVAFDGDVWTADSGKWVPDTTAPDEAFVEVRMAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPB4</accession>
    <name>A0A010ZPB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.85"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="689" mass="70316" checksum="7DE26321EF9F3994" modified="2014-06-11" version="1">MSEQRTVDGRYRLDKAVGSGGMGVVWRAFDLRLGRVVAVKEVRFPSAMSDDERDSLTKRAMLEAQSAGRLDHPNIVPVHDVILEGEQPFIIMRFVEGRSLDQTVSADGPLPDRVVARIGVQLLDALGAAHAADVIHRDVKPHNVLIQTDGTAQLTDFSIASVFGTETLTKTGALLGSPGYIAPERLMTGSTTPGGDLFALGATLFFAVEGIGPFVAKETIVGLFASATQPHPRPKFAGPRLTRVIDGLLEKKPEERLDRPEARALLLSIAETPEESETRSGEFVPPPPGRVDTDDRVGRGAAAVPGLPQGDLPSDNSTAVFAVRERSRPLASSAPSSGAPVSGGVVYGRPISGAPISGASSSAGVVYGRPVSGAPVSGAPVSGGPVSGGPVSGAPWAGVPTSGVPVTGARELGWGPGSNSGGSGHGNSGHGNSGHGNSGHGNSGHGNSGHGGPPPTFRPPAVPTSPPAGQRWKRLLAVVTIVVLGLGAGIIANLIATQDRGSKANRAGINIVDAPTTGNDTTPTTPPSPGAETSDEPGAQPVPTGTRPQPTPITSSPDPTDTSEPPTDPKVLSASLSVQQPTNPVDCAKQLTIVITVNVKTVGAAAVEWAVSRGGTTVASQTRTVTEKDTGFSVSPEDVMGKPAAGAHSYSLTIKAPTAVNAGPEIIEIKCAQADPGGTNTATPNPFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ11</accession>
    <name>A0A010ZQ11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014587_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="32443" checksum="2CE9FFD6298F1421" modified="2014-06-11" version="1">MVSTVRKIRTVRTVSDVHTVRNIRTSRSVCTMSTVRISRNVRTSRNVCTMSTVRTSRNVRTMSTVRTSHNVRTMSTVRTTRNVRTMRALRFVRPVRLIPALRHVSTLRHVGTLHFVRINGKRLSERDAQRILRRLHRRRSLRRRAVLRGTVQQRTLRRPTLQRRTLRRRSAHELRRGKQLRRSRSRLKIGWIGHTVRLRRVVNKPPAPISDHPRSRILQCRRVLQRGRPGLHVRIRRQAEIRPGPPRPLPPPIAVPVNEQQRPGHSRRRRRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ32</accession>
    <name>A0A010ZQ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725687.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1811"/>
    <dbReference type="HOGENOM" id="CLU_028880_0_1_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="428" mass="42198" checksum="37A40B63AB420A2A" modified="2014-06-11" version="1">MSAPIVAGGPGGTGGAGPGLPAVAEKQRSAAALLGRLARARELGLVVALFLLFGVTAIVNPRFIGVQSFKDILLNTAIVGLLAVGQTLVVVTRNIDLSVGSVLGLSAFVTGLLFADHQVPIVVAFLVGTLIGAVCGVINGVLVAVCRIPALVVTLGTMYVFRGADYWLAEGRQVNAADMPSAFLKIGSGSVLGIPILPLIALVLLALAAWGMRNLRSGRELYAIGSNPDAARLAGIPVGRRLFVAFVLTGTLSGIAGVLWAARYGTVDATAATGFELNVVAAVVVGGVAIFGGSGTVVGAALGALLLSTIGSALVVLKVEALWERAIDGALLLLAITLDRVLALRAERALRASASRGATTLPADGATGTPTRDGAAAAPSSDGAAAAPSPDGAGGAPPGAGAKGPGATPADGAPAGEAAADVAQGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ45</accession>
    <name>A0A010ZQ45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kef-type K+ ransport system, predicted NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_1859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569953.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1826"/>
    <dbReference type="HOGENOM" id="CLU_011722_6_3_11"/>
    <dbReference type="OrthoDB" id="1991946at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="10">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="32228" checksum="E46B9B90CEECA147" modified="2014-06-11" version="1">MRWWGARDGWLTRARRDGAYQRFVDRTDDVMLGLSVVFVVVLVWPVLDQGLSASAREWFHWADVTIWVIFVVEYTTRFVLAPERARFVRDHLPDLVVVLIPPLRGLRIVAVLPRLLGLVSMVGRLSRQSLAVRTGTYTAILAIGVLFAGAVTVYGAERDHPDANIRTFPDAVWWAMTTMTTVGYGDRFPVTAQGRAMAAVLMLAGIAILGIVTASIAAWFIGQFTAVASAVEEEVDRDVEILSAVRELSQRLERLESRLDDVVGRVDDTRHAEKGRTGTEPALTRDDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ49</accession>
    <name>A0A010ZQ49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ORF">CryarDRAFT_1864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849847.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1831"/>
    <dbReference type="HOGENOM" id="CLU_039592_4_0_11"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="32854" checksum="6F90AC063B15AD36" modified="2014-06-11" version="1">MSRYTEGSGARIVGLGHYQPARIVTNDDLTTQFGVETNDAWIQDRVGIKARRFAADGETALDMSVAAAGKALANAGIEAGDVDLVIVATLSPPTMLPNVASQVAARLGINAPGAFDVNTACSGFSYGLATAQHAIVSGAAKTALVIGAEKLTDVIDFADRTTCILFADGAGAAVVTAAEQNGIGPVYWGSDGPRGDVLHIDDGGYIRQEGQAVFRWATTALAPFARLACERAGIDPTELVAFVPHQANVRIIDHIAKRLGATNAVIARDIVESGNTSSASIPLALSKLVERGELPSGGPALLFGFGGGLTYAGQVITIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ56</accession>
    <name>A0A010ZQ56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849864.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1842"/>
    <dbReference type="HOGENOM" id="CLU_2259066_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="103" mass="10692" checksum="5D1E1E43687A397F" modified="2014-06-11" version="1">MPSEIRLPDGTAVVIHSPTGGPDRTYSGTWLAERICDGTPGRPDRVDVHYDTPTVGARAPVSVTVSWNVAPERPPSAADAPPGPPPGVVVPTQRPGAAPPTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQY6</accession>
    <name>A0A010ZQY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2150"/>
    <dbReference type="HOGENOM" id="CLU_026624_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458056" evidence="1">
        <location>
            <begin position="35"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="36519" checksum="E4B8E0D800B60769" modified="2014-06-11" version="1">MLTEEDDVSRLRVLLLVAVLVAAGLTVSAAPASADVGGLSNGVADDGARVISETFVEWQKLDIVIDSPAMKGQTPVRLLLPKDYFTQPDRKWPTLYLLHGCCEPADYRSWTQFTDVYDFMYDRNVLVVMPSDGLAGYYSDPRGSGPKYETYHITELQQIIERGYRGSSTRAIAGLSVGGFGAFSYAARHPGRFAAAASYSGLLDTLTPGAPTAIEWMRRQANESLFSLWGDPILNRSTWAAHNPASNLSGLRGTRLYLSCGDGRAADLDQNDDFVWQETAALLTTQSFVAKARAAGLSPTVRFYGRGTHTWPYWQREFKNSWPMLASALGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR25</accession>
    <name>A0A010ZR25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569691.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.691"/>
    <dbReference type="HOGENOM" id="CLU_1608117_0_0_11"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="165" mass="16830" checksum="E96339CACD3DC0EC" modified="2014-06-11" version="1">MVAGLVELPARSDQHVVLIVQRLLDGGASVVTTARTATDETPKGATFIQGDISTLAGVQAFAAAALRELGGVDIVVNNAAAARTHLGGIATIPDEEWLDALDLNFLSSVRVTNALLPALREAGAGGAIPGDPRDIAEAVAFLVSDRGQWITGASLNVDGGELPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR43</accession>
    <name>A0A010ZR43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+-transporting ATPase, KdpF subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850332.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202373_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="29" mass="3087" checksum="23F6E1EBB8657996" modified="2014-06-11" version="1">MSVENIVGLVASVLLVGYLLVALVLPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRB1</accession>
    <name>A0A010ZRB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848509.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.770"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22919" checksum="0F1FFF3D8A33AC77" modified="2014-06-11" version="1">MIRVYLLDDHEVVRRGLAALLESSGDIEVIGESGSAPEATRRIPALRPDVAVLDARLPDGNGIDVCRDVRSADPSIKALILTSYQDDEALFSAIMAGAAGYVLKQIRGTDLVDAIRRVAAGQSLLDPAVTQQVLTRIRDGHDDQPPELARLTGQERRILELIAQGLTNRQIGDEMFLAEKTVKNYVSSLLSKLGLERRTQAAILATKLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRH6</accession>
    <name>A0A010ZRH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848566.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.822"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="278"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="312"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="524" mass="55070" checksum="86BF3323BF8F40A8" modified="2014-06-11" version="1">MSSPVSTPHTGTTTVSVRGVGKSFGPNVVLRGVDLEIVGGEVVALLGANGAGKSTLIKILAGAHPDHTGEILVDGEPVRLASPTEARARGIATVHQRVREGVVPGLTVAENLAFDELAGGGASWALRRREVLEVARRAVEVLDLGWSDAVLRRDVATLGISDAQLLVVARTLLQRPKLLILDEPTSALSSAESDRLFGVVRQLRADGLAVLLVSHRLGEVDAIADRAVVLRDGRVTADVAKPLSWPVILPAMLGDSAEGLRATVLDHDRPTTDDAASSSTTSVVRLSGVRLFAESPELDLSLNGGEVTGIVGLIGAGKSELAHGLFGSARWPAGTADFADLARAPRSPAEAIRSGVYLVPEDRADQALLPGWSIQRTLSLPFITKVASRVGVLNQGTERDRATTVIEKLGIVARGPRTELNELSGGNQQKVVVGRWLVENARLLLLDEPFRGVDLGARRDIGEQVRAVANAGGAVVVLSADVDEVLEVADRVLVLVEGALTLDSPLSQVSRDDVVRAFSGEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRK6</accession>
    <name>A0A010ZRK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2317"/>
    <dbReference type="HOGENOM" id="CLU_022936_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="52899" checksum="1F341BFBCAA0DFDC" modified="2014-06-11" version="1">MIDDLSSLLDGFAGVVTPLNLLFALLGVTVGTAVGVLPGIGPAMTVALLLPLTYGLEPTQAFIMFAGILYGGMYGGSTTSILLNTPGESSSVVTAIEGNKMAKAGRAAQALATAAIGSFVAGTIGTLLLVLVTPLMVTFAVSLGAPDYLAIMLLGFIAVSAVLGASRIRGFAALLLGLTIGLIGIDRVTGQQRLTLDLAQLADGIDVIVVAVGIFAVGETLWVAAHLRHTIGQVIPVGRPWLGREDWRRSWRPWLRGTGLGFPFGVMPAGGAEIPTYLSYTLEKRLSRHPEEFGRGAIEGVAGPEAANNASAAGTLVPLLALGLPTNATAAVMIAALTSYGIQPGPLLLERESSLVWTLIASLFIGNLMLLVLNLPLAPLWAKLLRVPRPYLYAGILFFASMGAYAVNAQPFDLLLLLVLGLIGFGMRRFGLPVLPLIVGVILGPIAERQGRMALQLSGGDPSGLLGGALSYVIYVTIAVILLWPVLRRLTATAVRTRHREHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS60</accession>
    <name>A0A010ZS60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850850.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2587"/>
    <dbReference type="HOGENOM" id="CLU_009942_3_0_11"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="38"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="454" mass="47913" checksum="0D8FCD6621335300" modified="2014-06-11" version="1">MLIRRAEVDGIDGIDVRIGGGRVVEVGAGLARRNGEPTVNARGGALLPGLHDHHVHLRAWAAARSSVRLADVRTPAEFDRQVRDAAARADGWVRGVGWHESTAGDLDRHRLDALTGDRPTRIQHRTGALWVLNSAALARTGAAGSTVDGIERDPAGEPTGRLWRADDWLRERTAPARDPFPATLAALAAEATRFGVTRWTDATPGRSDAETDALAAGWSARYPELVVMSPPGTRTDVPGLRRGPHKIVLDDRTLPSPGELAAIIGESHAAGSPVAVHCVTAEQLVTFVAALEEAGPVRGDRVEHAGIVPPGHAARLAALRVAVVTNPGFLADRGDAYLRDVPAPERDWLYPVRSLLDAGVTVAAATDVPFGPADPWVAVAAATTRRTGSGVVLGPDERVSPATALALFLTDPDHGGHRRRVAVGQPGDLCLLHTPLAVALAEPSAEQVRAVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTD2</accession>
    <name>A0A010ZTD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ORF">CryarDRAFT_1556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849389.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1529"/>
    <dbReference type="HOGENOM" id="CLU_009281_12_0_11"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="238"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="468" mass="48296" checksum="78531CCD6E57F68E" modified="2014-06-11" version="1">MALVAGVDCSTQSTKVLICDSETGEVVRQGRAPHPDATEVDPAIWWSALQTASDGLLDGVEAMAVGGQQHGMVTLDADGNVVRPALLWNDTRSAGAATDLIDELGGAQAWTDAVGLVPVASFTVTKLRWLAAHEPEQAKRVEQILLPHDWLTWKLSGRSIAPTTDRGDASGTGYWSAATGEYRLDLLERAFGREIGVPRVAAPAEIVGRTPEGIALAAGTGDNMAAALGLGAGPGDVVVSLGTSGTVFAVAEASTNDPSGFVADFADATGRFLPLVCTLNAARVLTAAADLLGVDLDRLSELALASTPGAAGLTLLPYLDGERTPDLPDETGRITGLTRANARPENLARAAVEGMLLGLADGLDAVRQHGVPVRRALLIGGAAMSPAVRAVASGILGVPVDVPAPGEYVALGAARQAAWALSGAAEPPRWTVAAEHTPDATDDYSGARDRYAQFRTGVQELSSRSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTH8</accession>
    <name>A0A010ZTH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060481_0_0_11"/>
    <dbReference type="OrthoDB" id="1355200at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="31707" checksum="D2A2BD519223EF14" modified="2014-06-11" version="1">MNHEPETSPRARIPADVEIPDRIAFGLTARQLAVLAVAGTAGLGLFRVTDGLLPPAFIVAVLVPLAGAAIVLALGKRDGLPMDTWLLAALRHLPAPKRFAPPTQTPAWAPHAERPPRTVPHLRLPADAIAESGVINKSMALVACTTVNIDLRTAHEQAALLGAYGQWLNSLTAPVQIVVTTQRVDLSGHAHRIARSAGMLPNRALAGVANDYAAFLDELAARRDPLQRTVLIAVTSSGSDVLRRADHTASTLATLGARTAVLDGTRATAVLTAATDPYTPSDTTWPRARPGTVLTGRSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTJ9</accession>
    <name>A0A010ZTJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3288269_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="40" mass="4452" checksum="ABB8298EAB4E1920" modified="2014-06-11" version="1">MTAKAVLLVSRIQDPMWFDICASVDVTLLAGDDEKAWQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTN7</accession>
    <name>A0A010ZTN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CryarDRAFT_1662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849531.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1632"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_11"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="169"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="492" mass="52199" checksum="0B1B10A6598D5E19" modified="2014-06-11" version="1">MSELSALRYLAGLEGAAPDPGALAFFASLDQITTVDPTVAGGIVQELTDQRSNVKLIASENFSSLAVQLAQGNLFTDKYAEGAPGHRFYAGCDNVDTIEAHAAGLARQLFGAEHAYVQPHSGIDANLVAFLSILATRVESGIIEKFGRKNASALTDAEWAELRREVLDQKLLGMDYYSGGHLTHGYRFNVSARLFDARSYTVDPETKLLDLDAVRAQVREVRPLILLAGYSAYTRLIDFAALREIADEVGAVLMVDMAHFAGLVAGKVFTGDHDPVAHAHVVTSTTHKTLRGPRGGMVLCTSEFADAVDKGCPTVLGGPLPHAIAAKAVAFTEALEPSFASYAANVVENARTLAAELQQRKVEVLTGGTDNHIVLVDVAASYGLTGRQAESALRSVGLTLNRNSLPFDANGPWYTSGLRLGTPAVTTLGMGADQIAEIADVIATVLAAVTTDGSSKAKFALDSAVAAEARTRTSDLLRDFPLYPEIDLGLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTQ9</accession>
    <name>A0A010ZTQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851658.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="30165" checksum="15812B4DD04E0E93" modified="2014-06-11" version="1">MADLTGQVALVTGAARGQGRAHALALAEAGADIIAVDACADVETAPYPLATAEDLAATVKEIEKLDRRVVAAECDVRDSAGLDDVVARGLAEFGRIDVLVANAGIWALGRLWEITEAQWQEMLDINLTGVWRTVKAVVPHMIEQKRGAIVLTSSVNGFEAGGGMTHYVAAKHGVLGLMRNAAIELGPYNIRCNAVCPGIVDTKMNDWPGAYDMMAGHEGGTPEDRRHNAYGWSALAGRGLLDPRTVSRSVVFLVSDDARDITGVALPVDGGHAVLPGSNPDPIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTS1</accession>
    <name>A0A010ZTS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849574.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1667"/>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="168"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="36466" checksum="3890073D6274A92C" modified="2014-06-11" version="1">MSQQVRVAVVGTGPWWGRQHAIAFSTRTDVRLCAVVGRTRPRTEERAAEFGVPGYVDVDDMLDREKPDLVAVCLPNEGHFEPTLRIIRAGFPLLVEKPLVFDLDQADQLLAEAAGRGLFFAINFNHRYAKPVQLAREAVDAGALGRLTFATWRFGGEAGTSAHRHANLIETQCHGLDMLEHLCGPISSVMAQMTDVTDRGCSTLSVALRFENGAVGSLLGTYDSSYSYPDTHRLELNGLDGRVVVEDTVRRYTFTPAGHEISSVWQAGYFNDRERHFHATFDRHLDAMLPAFAAGEPPPVPATAGRRALRLAHRIIDSFETGTRVDTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUA5</accession>
    <name>A0A010ZUA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2914761_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="61" mass="6773" checksum="844CCED4FCD55E17" modified="2014-06-11" version="1">MVARSPQDALRRFGQDLHRGGRLQYSTADGDLVVEWGNVATLEVGPIVRVVRIVGRPDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUA8</accession>
    <name>A0A010ZUA8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1829"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="430" mass="43589" checksum="579AD6850C320D40" modified="2014-06-11" version="1">MTERPSAEVSAAQAVSAASAPTGAGANVEVLVTGLGATTPLGGDVSTTWQAMLDGKSGVAALTDDWATDLPVRIAAKLAVEPTEIIERVKARRMDRVQQVAVVAAREAWSDAGSPDVDPERLAVVVGSGIGGALTLLGQWDVLREKGPRRVSPLTIPMLMPNGPAAVVGLEVGAKAAVRAPVSACATGAEAIAIGLELIRTGKADVVLAGGAEACIHPLPMAGFGAMRAMSTRNDEPERASRPFDKARDGFVLGEGGGMVVLERAEHARARGRSGYAVLAGAGITADGYDIVQPDPSGSGQARAVAEALADGGLTGADIQHVNGHSTSTPAGDMGELIALQKAIGDHPVVTATKSMTGHLLGAAGAVEAIATVLAIRDGVVPPTINLENPDDGVCLDIAANTARKMKITAAINDSFGFGGHNVALAFREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUK0</accession>
    <name>A0A010ZUK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3493"/>
    <dbReference type="HOGENOM" id="CLU_1737498_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16481" checksum="063978542C7F658C" modified="2014-06-11" version="1">MGNTEIAREFIAAYNAHDAERKAALMTEDGRVEFPALNISHGAGWETTSGSNAANLVDDRTIDVQRITASGDAVVIEMLWHGVSKGGPGLAPAGERVEMENCIVLTFRDGLISRYVEYFGRYEGIDLLVLRGRMLERRQPVRSGSPSDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVD8</accession>
    <name>A0A010ZVD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3826"/>
    <dbReference type="HOGENOM" id="CLU_000537_7_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="39814" checksum="6D70A6C69243694B" modified="2014-06-11" version="1">MSMKILFSTSPAFGHFIPLLPLARALRAQGDTVAVLSAEILRPAVEPEGFTFLAAGVPMDVALAESIRRTGHSAADDPEPEGVAGLFAGALLDFAADEALRVAAEFAPDLIVNEFTDFVGPLVAESLGVPSVTMTFGPLLPSIYTDAMTRTVASRYTDRGLTPPATTPSGRLLLDVCPPQFQFEGATPPIESVLLRPEAHRVPGLSVSPTGPSHRSRVLVTFGTVFTEVDVLQPILTALADVDVDLLVTLGLFAKPEQFDVNPERVEFTPFVPLAQLLDGVAAVVSHGGAGTTLGTLSRGVPMVIVPQGADQFLQADRIVASGAGLALPVGAAEPAAVADALRRVLAEESFAAKAREVQAGIAAMPSPEEIAAHLRTIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVI7</accession>
    <name>A0A010ZVI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850449.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2290"/>
    <dbReference type="HOGENOM" id="CLU_039483_1_1_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="24708" checksum="D80B8F7D183AFAE0" modified="2014-06-11" version="1">MFAIARSELIQIFRNRLVLVSGFIMPVAVGAFFVYRHEVFGELASLGYIAAVVACTVGAFGLYTSLVTTLASRRQNLFLKRLRSTAAGDAGILVGLALPATVLALVQAVGMLIVLGAVAGGPSNPVVVAVAVVATFAMMLGLGLATAGLTNSPEHAQVTTLPVSLGVIAVASWVGIAGTESLTLLKRLLPGGAATELIVGAWNGGVAVGESLLLLAPTLAWVFVALTLAARMFRWEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVK7</accession>
    <name>A0A010ZVK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570644.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3893"/>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="32418" checksum="1F38E5BF236A868C" modified="2014-06-11" version="1">MNSDDLRTMLLIRHFELALLDLFARGEVHGTTHTCLGQEAVPVALSPLLDPDDFVFSNHRGHGHYLARFDDPAGLLAEILGRDGGVSGGVGGSQHLRRGRHLSTGVQGESLPVAAGTALHLARSEPGRLACVYVGDGSWGEGAMYEALNMAALWRLPLLVAVEHNGIAQSTPTAAAMAGTIAGRAAAFGVEHLHVDATEPGVARLRTALAAPVERVRRGAGPLVVEFATRRTGPHSKGDDSRPAGELDRLRTQDWYARLDGPEFDRLDAEQRARVAAVVRDVTARPPATGRVAAEVEQWQPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVT7</accession>
    <name>A0A010ZVT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850601.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167343_2_0_11"/>
    <dbReference type="OrthoDB" id="2087009at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="83" mass="8846" checksum="789EB7B4B6EF0622" modified="2014-06-11" version="1">MRRLFWIGVGAAVGILVVRKISRTAEAYSPKGLADSARGSAIGLLDSVRDFLEDARVAMAEHEVELTRALQEGTAEGGAHRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW50</accession>
    <name>A0A010ZW50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850774.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_10_0_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="23131" checksum="13B6C4B96B040219" modified="2014-06-11" version="1">MDEPGGGGGRRRGRRPGSPNTREAVLAAARSAFATHGYGKATIRSIARDAGVDPSLVIQFFTSKEDLFRASLELIVGPPEDVAASVAAAEGTLGTRMATFYFGLWERSETRPALTAMALSAASEPEARNAIRQLMGRQFIGPIAEHIGAERAARRVPLAATQLLGMAFLRYVVPTDPMASMPVADVIQVVAPVIDRYLTGDLDAVLTAELRPFGAAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW55</accession>
    <name>A0A010ZW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850786.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2522"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="30688" checksum="7D19CEA0078974DF" modified="2014-06-11" version="1">MRETTAERWSRRIVLTLLTLFVLVPLYVMLSTAVKPLSDVRDAFTWLPKRLSFEAFVDMWDTVPLGQYLVNSLIVSTAAAVLSVAIAILAAYATSRWRFRGRGLFLASALSTQMFPGILFLLPLFLIYVNVGRATGIELYASRTGLVITYLTFSLPFSIWMLVGYFDAIPKELDEAAAVDGAGPMRILFRVLIPTAVPGILAVTVYAFMTAWGEVLFASVMTDETTRTVAVGLSGYSTQYDVYWNQIMAASLVVSVPVVAAFLFLQKYFVAGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWB4</accession>
    <name>A0A010ZWB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2585"/>
    <dbReference type="HOGENOM" id="CLU_083287_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="17907" checksum="A8895E03F7DFB455" modified="2014-06-11" version="1">MDGVTDGAGLDPAELGAYFALEEVSSLLAHAIEQHLRGEGLTSVQFKVLMQLFDAPGGQLRMTDLADGLVVSRSGLTYQAGLLERAGLIARAPSPDDERSTTVSLTAAGRDRIFTVLPGHVEVVRRLLLDPLPREDLSALSGLLTRVRDHMRADPPRSATPRSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWD6</accession>
    <name>A0A010ZWD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570101.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2612"/>
    <dbReference type="HOGENOM" id="CLU_054040_1_0_11"/>
    <dbReference type="OrthoDB" id="505342at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="44507" checksum="187D52068B52DB02" modified="2014-06-11" version="1">MTDNENQFLRATAFTQPFADAIVEAEKIIADAPHVKTEQDLLEGYDYLAGSIKASLHMAWAYEREFPFFTQSTGPYTKMALDNPDTLYFNAHLRPEAEYVVTGRRGTTRDLSFQVLSGDYSPAEVPDSPSAFDDRSIDVAADGTFEVRFGPGAARKNYVTLAPGATMLAVREVYSDWATETRGEIRIHRVDTAGGAPTPPTAAQLEKRYAVAGKMLLSRLRTWLQFPEWFYLKLPVNTLTEPRLTPGGLSTQYSSAGHYELPDDVAMVVTVPKSDAPYQGLQLGSRWYISLDYQNHQTSLTTDQAKADPDGLIRFVISEQDPGLTNWIERTGHDRGFVQLRWQRVARAMTAADGPTVELVPVSELADRVPYHQEQRITPEAWAARIAGRQAAVNRRMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWN3</accession>
    <name>A0A010ZWN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein, gamma-carboxymuconolactone decarboxylase subunit like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851033.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2712"/>
    <dbReference type="HOGENOM" id="CLU_096750_0_0_11"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="28129" checksum="4F019E955737ED6F" modified="2014-06-11" version="1">MTLTARQEEIKQEFVRVRGTWSDTWESVLRLDPEFLAAYLNLSAVPWRTGTLEPKVKEFLYIAIDANATHLYLPGVRQHIRAALSLGATPAEIMEVLELTATLGIHAMNVGVPVLVQVLEEKGLRNGPAPLDEYQERLKADFTATRGYWHSFWDEMLELDPEMFAAYTEFSSLPWRSGTLEPKVKEFVYIAFDTAATHLYVSGLKLHIENAIGYGATPREILEVMEIASVLGIHSVTSAAPILLEEAQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXU0</accession>
    <name>A0A010ZXU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851557.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265195_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23061" checksum="DD0F159509025E76" modified="2014-06-11" version="1">MAHRHDQSGSRPEPASGSPFEIPDPYGQTEGSASASGVAAPLLAGGALALAGVVVQQEDALRYPGVVLLVLVGAILMLVASVQCGMWARQYAVAPTDIQQWWPDPNLTRKAAILRDQKFHAHRHRVWAVRVTLTFNLGVLLLWIALAVAVAPKSDVHEPAWRWGAATLAALGVLAEAAWIALVARGPVVPGQCLGWASRWLYGKPVTPPPAGPGSDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYA3</accession>
    <name>A0A010ZYA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851814.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3294"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="28656" checksum="2335304B37665F6E" modified="2014-06-11" version="1">MTVLVLGARGTTGSRLARQLTDRHVDVRRAGRSAGTDVYFDWSEPDTFAPSLHGVGAVYLLAPVGVVDPEPVILPFLGAAEKAGVERVALLGSSAIPMGSPGLGTVGTRLRDFVPGWAVLRPTWFASNFTGDHLHARTIRSHGEIVSATGDGRVPFIDPDDIAAVARRVLVGPAAPQRDLILTGPEPLSFDDVAAQLTRPDRAVRHRRVTEAEMSRRLREDGIPPAFADLLAGMDTAIARGAEDRTTGTVEEITGRPPRSFARFSIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZA2</accession>
    <name>A0A010ZZA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570575.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3704"/>
    <dbReference type="HOGENOM" id="CLU_028723_10_0_11"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="157" mass="16837" checksum="2E6AEE3272D693E7" modified="2014-06-11" version="1">MTVARVAGALLATSIAAGWWLHRRFVVVTVLGESMVPTFAHGDRVLVRRVRLARARAGDVVVAAWGVPEPGGPFPRTIEKPTPGRPSTLAPWMVKRLVAGPGDAVPEVVRPTVPDREVPPGRFLLLGDNVAASADSRVRGYAHAEYLLGVVVSRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A005</accession>
    <name>A0A011A005_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852747.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3971"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="22497" checksum="12442A7648BA2317" modified="2014-06-11" version="1">MDLELNGRIALVVGGTGFIGRAIVERLRNEGATAIAAARTVDDGIPLDARDPGSVAAGLATVLDTHGRLDALVVAAAPSARTLDPARHADPEQVLDAIDAKALSFLRLVNAVLPVMTGAGYGRIVGVSGQNAFLTGSVTGSVRNAALIVAAKNLADGVAGTGVTINTVSPGIVAAAPATAVEAGRPGESSPTEIADLVAFLVSPRAGAISGESIAVGHRVRGVTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABC1</accession>
    <name>A0A011ABC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064089_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="123"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="25783" checksum="C85FF8C45653FA5D" modified="2014-06-11" version="1">MSVAAGSMLLIVAFLVARPTARRRLKRSTRVGAADGSAGEGVVGSGVHPGASGGPAGSGGSVALRWVVPCSVGLAVAGLVGTWWGLIVGAAVGVGVHRLVRRMPSPAINREREAAAAELPYAVDLLAAVLKSGAPLDRAVAVVGAAIGGPLGERLALVGRALRLGVVGEPGWRALDDVPGAEGFVPAAVRAADSGAALAAACTRCAADLREGREARAEAAAHRAAVWVVLPLGFCFLPAFVLVGVVPIVLGVLDELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE84</accession>
    <name>A0A011AE84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569855.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104647_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="210" mass="22469" checksum="CEF469D98DEEF56E" modified="2014-06-11" version="1">MSKSVAPRTAPVLYSARTGQAMRQLVGDLIAVGLVWWAVRLQGWVDDQISKLAAPGETLQSAGNGFSGGLSNAGKQVGRIPGVGDDLREPFDRAAGAGQQVAEAGKTLHDTIEQAALVTGLIAAAIPLIVVLWWVLRRWRWSREATAARRLVRGGADASFFALRALAHQPLSEVIRVARRLEVDPGEAWRSGHPEAVAALAKLEMSRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG96</accession>
    <name>A0A011AG96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2107"/>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="28376" checksum="67DC541410D89EC5" modified="2014-06-11" version="1">MTSMLHAPRSRTPVEVDSFRPSAARMYDYYLGGRNHLAADREAADALLDAVPEVVTAAQQNRAFLRRVVEYAVGQGVTQFLDLGSGYASPGGVPEVACAGDATSRVVAVDIDPGVTAQVGSTARATGVSGRVGAIHADLRDAIGVLEHPVTRRLIDFDRPVAILCLAVLHFVPGELDRVLGPLRRAAPRGSLLAFSHAAASEAPTTTERITRLVYDCTLTPLVLRSEETLTAAVSGLELVDPGIVPVNRWRAPDADAPASTLLGGVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGV5</accession>
    <name>A0A011AGV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850461.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2294"/>
    <dbReference type="HOGENOM" id="CLU_097062_2_1_11"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="17275" checksum="E4D54F16DBE7D1D1" modified="2014-06-11" version="1">MRSNRPMYETFLDEHRAEIVASLDGLTEEQARRPLVRSRTTLLGLVKHLIFVEKVWFDEAITGRSRAEIGIGASPDESFVLEDGDTIASVVAEYEQTCAESRRAAAALSPDDVVTGNRRGPLPMQWVYLHMLRETAQHCGHADILREQILAAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH14</accession>
    <name>A0A011AH14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861853.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2359"/>
    <dbReference type="HOGENOM" id="CLU_102515_0_0_11"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="18638" checksum="8067D73FD18A20D2" modified="2014-06-11" version="1">MTFYVVLVLLVGVERLAELVVAVRNKRWALERGGREYGAGHYPFMVVLHTALLAGCLAEAFHRPFLPWLGWPMLVLAVAAQALRWWCIRTLGHQWNTKIIVVPGMPLVTGGPYRFFAHPNYVAVVVEGFALPLVHSAWLTALVFTVLNAGLLTVRIRAENAALRAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHZ3</accession>
    <name>A0A011AHZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851031.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2711"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="243" mass="25399" checksum="D6F8A649ED9C106D" modified="2014-06-11" version="1">MDSTAVVTGAARGIGREVVRRLRAEGYRVVAVDRDPGVAALAEDGRVVTVTADVTADDTPAAAIGRAVSEFGRLDLLVNNAARFLRRSIADTTDDDFDTLFATNVRPAFRLARAALPHLERTRGSIVNTASISGLVGVANQSVYAMTKGAIVQLTRQLAIEYAARGVRINAVAPGAVDTGFMDEARRADPDPAASLAVTLGNHPIGRMSTPDEVARAIVFLAAPESSGITGTILSVDGGYVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIH5</accession>
    <name>A0A011AIH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2878"/>
    <dbReference type="HOGENOM" id="CLU_009583_16_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="204"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="40832" checksum="524281784E542E70" modified="2014-06-11" version="1">MTGGYLYHRRVADRAAAHDALLEFVSVPERSFAASVAAGRGLLADLAARAPDAILLDSIAAAYLGPWLRRAASSPTAGASATAGPATAGPGAAQGAAQGATPGAARGAGGRGRWRWRARGLPPIVGMLHQPPGGIDHTGVRRTVQALLDQRAYRFASKLLIASEDLADTLRASGLPADLLTVVAPGRNPADDAVAPAADLRQGRRTAVLSVGNWVERKGLLDLLEAVATLPADAVTLHLVGDPDIDPGYAARVRRRLDRDDLAGRVTIHGLVTPAEVVGLYRAADVFALASVREPYGTVYGEAMTEGLPVVGWDAGNLPHLARHGREGFAVPPGDVAALAAALRTLAEDDERRHTMAAAAKARSESFPNWDDTARVLFTEIRAVVEETRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIY4</accession>
    <name>A0A011AIY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570253.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3068"/>
    <dbReference type="HOGENOM" id="CLU_012069_0_1_11"/>
    <dbReference type="OrthoDB" id="1509644at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArdcN" evidence="2">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="208"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="36322" checksum="2542913F5962D53C" modified="2014-06-11" version="1">MSHDKDHTALLEKLQADFDERLAQIASEPAQWVEFLERVAVFGAQYTLTNQLLLLAQADERGITPRYFLPFGNRAGTTGWKAQHRHVRPGENAFKVWAPIRRRPTDEQAAEREAAGYTVVREPSGRPAVQVVGFRLANTFELSQTDGEPFEPPTVLRRRRAAPQLLTGDDPTGAYPDLVTLINAAGYHYELIAPATGYLGAANGVTVHRPDVRVVQVRNDVSPAQRTKTTAHELAHIRCGHLDQQLTRTDLHRGRRETEAESVAHIVLAALDLDTSAYSDAYVLDWAAGDLALIRSCAETVLSVAKHILLDLRPGPEPSTPAPSAEKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ03</accession>
    <name>A0A011AJ03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422568_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="648" mass="69211" checksum="E8CCA2ADDEC474F3" modified="2014-06-11" version="1">MLAANAKAAAHHATKALVAAGESVAEIADRMPDAQTKADAWFAGLAVLADPRERRAMAGRALAALRASARSERWPADEYVRAAPVLGTAGDQAILRAAYHDVRHAPDDGYGSSGKLIAAFAEAFASAGDLTGIEMTLSDASAIADNTFALTALTGVARAHADARLPLDMVRTAGRRLHAHFAAPWALDTEIAFSLAEAARATEALDILAEVLTEAQRPRNVEAAVAWRKAFAQQLASRHPLDAAELCQAALAQGETLATSNDVEVALRLRPYLAEIDPQRRLEMQAQGMEWERVVETNAPVLPLLAETGDRAAVDAAVDRIEDLVNVSFSFIQAFTACLGPAAEALLISGDTDRFERLIANHQQLELGGIVAAADVLTTLNFQIRIAGLDQIMRDWAAAMTKYVTLSRHQLALRTTAILNEAIGARAIADNLRSRITDPVEQAEAALRIAAQALIKDDRGRARRLIDEFELLIPALPAGMRPGFFSLAVPILRELGDSRDSDWTHEALSQLDAGDYYATRPPAAAIILQKLAEETVEADPLLARAARLGSPYHARQTAAEIAMQAAELPPPGGYPPLVASEVRAATAIRDGDVDAWRSALRDETLVSLVGVARRIAGGAGLLYDIDGGETLLALSRAMSQADLVWSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ07</accession>
    <name>A0A011AJ07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570276.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058041_0_0_11"/>
    <dbReference type="OrthoDB" id="1643101at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="34875" checksum="42173DD989E8E446" modified="2014-06-11" version="1">MVTRRPPRHSPGGELPAGSQTTLLEIDRRLTPRDHTIALLLEDHTTLTTDQLTSVLFDAASTARHRLHLLRRIGFIDRFTRNYPGSNQPICWLPGLLSSRYVALTRDENPPTLKTLRERQDRVYSSRILDHTLATNAFFTALLADGRRRSEGGLLRWWSERQTAARFGRRINPDGHGVWSDGTQQTGFFLELDRGTEPLGRLVDKLASHRRLRAEAGPRYPLLFVLPSRAREQNLHRRLADRPEPTLVIASTCAESGYHVVGPFGPIWRLAGNGRHRVPLAELPSNHGQPGPLTPGPPLPDEHPLHLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ48</accession>
    <name>A0A011AJ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851582.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3139"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_0_11"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="79"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="33512" checksum="9112124B749E2DAB" modified="2014-06-11" version="1">MSEVVLEAAAQEFADATSKPPFIYQLSPVEARKVLDDVQAGPVDAPPVDDEWVLVPASVGDVRVRIVKPQGASGALPVVLYIHGGGWVLGNAGTHDRLVREFAVGSDAAVVFVEYTPSPDAHYPVAIEQAYATARWVVAEGAAHGLDATRMAVAGDSVGGNMTAAVAILAKQRGDVTFVHQSMYYPVTDARQNTESYRTFADGPFLTAAGMAWFWDNYAPDHSVRSEITASPNLASPEDLAGLPPAFLLVDEADVLRDEGEAYAGKLRAAGVPVTTVRYDGISHDFMMLNPLKDTHAAKGATAQAIAVLRQALGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL32</accession>
    <name>A0A011AL32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_39_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="32869" checksum="728D0CF72AA6DB3D" modified="2014-06-11" version="1">MPVSSPNLDANLAVALDALLAECSVTLAAARLRTSPAAMSRTLARLRRVLRDPLLVRAGQTMVLTPRAEALRDEAAAVVGRLEALLAPGGDVDPAALVRTFTVQASDLVGAALAPGLLGPARSRAPGVSLRVLTEDGEAGPALRDGRVDLEIGAVDHSDPETRIEELVTLRFAAGVRAGHPLGQGPVTPARLAEADHVVVSRRGHFSGPLDAALAGHGLTRRVTAVLPGHLAAMALAAASDVVCLVPVARPGEPPTPITDAARALGLDLVEIPVTLPPLTISMAWHPRHSADGAHQWLRDAVRRALRPASPRGAGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL38</accession>
    <name>A0A011AL38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852601.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3833"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="33075" checksum="19EC9FA7159DE61B" modified="2014-06-11" version="1">MNTPPTMRALRQMSLDGPQALRLVPDAPVPGPGPGEVLIRVSAAGVNFRDVMRSREAFPGDPRPPFVAGFEAVGEVVAAGTGVSDPPLGARVTGIGEGAFAEYLALPAAAAVPVPPGWRDRDALGLVVNWPTALAALKPFGRLAAGQTVLIHAAAGGTGQAAVRLAKHYGATVIAAASPGKHDVVSALGADHVLDSSDGDLTGPVRELTGGKGVDLVLESAGGTAFAASLAVATPVTGRVVVYGLAGGDAVLSNRGLVYDHQVHVIGLNLGVLIGRAPRIFGEVMAELSALAAAGVLVPGAPAVHDLAEGPRVLAALEARTTVGKLALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALD2</accession>
    <name>A0A011ALD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3907"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="246"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="495" mass="52120" checksum="CD86EBCEA4B086A0" modified="2014-06-11" version="1">MSLIRVDGLSKSYAGTVAVRGVDLEIRAGEIHALCGHNGAGKSTVVRLLSGQESPDGGAIAIDGVPVELKTRRDAQTAGVALVDQELSVVPSLTVAENLVLGDRDAGWLNRRRAQHRRARRMLDDLGLTHVRPEQRLATLGLGERQLVEIARALGQRARLVILDEPTATLTDVESEHVYAAVRSVAAAGCAVLFVSHRLGEVLTLCDRVTVMRDGAVVTTSDAAALTVPTLIRHMLGESPQAAPRVRAESGETVLELTGVSVPGRFGELSLQVRAGTVYAVAGQLGSGASDVLRGLAGLHPAMAGEVTVGGARLRTADPVAAARAGIAFASNDRKSEGLFLDRSTGVNLLVTRIPALSRFGLVGTRRWKETESRLAERCGFPAHQLARPVGQLSGGNQQKAFVGRSLDRPGTRVLLLDDPTRGVDVGGRAAVHALVRDAAAQGVAVVFSSTELDELVDLADVVLTMYQGRLVSRHDEAVPGAVLLHEMTHGAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG22</accession>
    <name>A0A010YG22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.190"/>
    <dbReference type="HOGENOM" id="CLU_019399_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="56"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="354" mass="36837" checksum="115876C731D4A535" modified="2014-06-11" version="1">MARGQRRRNEKGRWVLIGVAVVAVIAAAATAVVFLRDGDDGKDGTVTAKTELGTVYAPYVYVTLADRPSLTEIAQKTGANGLHLGFAITKGDECDLTWDGTTALDTYKDEISAAAAKGIEVIVSTGGASGGDVTQACGDAETTQEQLQKLVDLGVRYLDFDVEGEERVADTEANEARAKAILALQQKNPDLKVSFTLAAASPTDATTAAGAANTAPWVAAVDAGVAIDRINLMTMNFGGTVAPQDMAAATTAAATGLHSQIETIQGIDSANAWGMVGITPMIGVNDLNTETFSLDNAKTVTDFAVKNSVGMLSFWSAGRDTQCGADVTKQPVANCSGVEQDEYAFASIFKGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG51</accession>
    <name>A0A010YG51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative branched-chain amino acid permease (Azaleucine resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847723.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.225"/>
    <dbReference type="HOGENOM" id="CLU_065777_0_1_11"/>
    <dbReference type="OrthoDB" id="1866750at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="23796" checksum="585B794F79318C3A" modified="2014-06-11" version="1">MRSIYRTLGPEVIRSIALVCLADALVGVSFGAIAVSAGFPLWIPILLSVVVFAGAAQFLFIGLIAAGGSPLAAVAAALLVNARHLPFGFAVGDAIARVGFLRRLIGSHLMTDETVAFTLAEDDPRRRRAVYWATGSALFVCWNLSVVLGGLAGTVISDTDALGLDAAFPAVLLALVLPSLSDPRTRWAALIGVVIALATTPVLPAGAPVLLALIGVAVVGLIRRRDRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGV2</accession>
    <name>A0A010YGV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848208.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036795_0_0_11"/>
    <dbReference type="OrthoDB" id="864839at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="38042" checksum="83B4C820C1888757" modified="2014-06-11" version="1">MDYYFFTSHSSSEDERGAVKRFHDDLERQLWVQAGLGVGGILDRYGLAPGWERSTTDRADWVPSMVALCSGDYFADPDCREEWVRFAGRVRKHTAERAPAEKCLITVRWRGSLPQRPEGVEPRYLNRAWWPPVHGPDDGSGLADFMRHRGQSKEYYAIVTDVVRQILEAKHIDLAADPSSTGPEPRSEPRESEVPVVRDNAVRSIAISYVGADQPWADWLRGVFREKGHQVDLFRWNAHHETSLKDSLDVAASRTDRVVVLLSRHYLINRSRQPQDWESALVDSAHPEKIVRVRLDSTPLPAELRTTSMITLEQPTAEVVDELVRAVESAPVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHU9</accession>
    <name>A0A010YHU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848629.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.889"/>
    <dbReference type="HOGENOM" id="CLU_013049_0_1_11"/>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004546">
        <property type="entry name" value="Restrct_endonuc_T1M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00497">
        <property type="entry name" value="hsdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="525" mass="58253" checksum="DA6813B1F9B38176" modified="2014-06-11" version="1">MAPTSKEAQRAELHKIIWRIANDLRGSVDGWDFKSYVLGILFYRFISENLTAYLNRLEREAGDADFDYAKLSDKDAEFGRKDTVDEKGFYILPSDLFANVCKRAANDENLNETLSRVFADIEGSAVGTASEDDLKGLFHDLDVNSPKLGPTVAKRNEKLVKLLDAIGDLDFGNGGFSENTIDAFGDAYEYLMTMYASGAGKSGGEFFTPQEVSELLARIAVAGKKAVNKVYDPACGSGSLLLKFAKVLGKDNVRQGFFGQEINLTTYNLARINMFLHDINYEKFDIAHGDTLTDPAHWDDEPFEAIVSNPPYSINWEGASNPLLINDPRFSPAGVLAPKGYADLAFTMHMLHWLAVNGTAAIVEFPGVMYRGGTEQKIRKYLIDNNYIDTVIQLPPDLFFGTGIQTCILVLKKSRNENSVLFINASAEFKRVGNKNKLLPANQQRILDTHTGREIVEHFSALVPTRQIADSDYNLSVTAWVEVKDSREVIEIAELNKRIADIVARQAELRTQVDTIIAGMEGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI81</accession>
    <name>A0A010YI81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848744.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1016"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457602" evidence="2">
        <location>
            <begin position="25"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_MalT" evidence="4">
        <location>
            <begin position="502"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="606"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="827" mass="87690" checksum="D577C9B9893E63F6" modified="2014-06-11" version="1">MRRALVLVALTLASAVTSVLLAVAVNVATGGELPPGLAPAEPLAWPAVAVAGLVTAVLAYWQQRPLGGAEPEPVAVDPARPTPPAELPALPALFTGRQSEADRILAAIDGGAPLVAVSGPGGVGKSALILHVAHLVHSRYPDGTLFVRLRGASSEPADPAEVLPRLLRSLRPADGDDGELRGDVETLAARLRTRLAGRRYLLVFDDAGGADQVRPLLPGASGSLVLVTSRPVLAELTSATLVGLEEFSDAEARELLARLAGDQRVSADPAATEAVVRACGNLPLAVAIAGSRLRARPSWSMATLAGRLADEERRLDELSSGRDAVRASVAATYTELDAYHQRVFRRLGAHPGTDFDASAAAALADLVGSGAVPALDRLVERQLVQVTTSDRYRLHDLLRLYAIEELGAEYVDALRRLADHYAARARAAIEPWVPWEAAFGPRSESGDPEHRAYVDDERENLIATVTAAAQHRDGHPELREAAWSLAAAAEPAFTRYPYHADARRLWEAGLAIAHSTGVPERIAQAEYAAARASQYSGDVRGGLAHARASLSWWERAGHRLNTAAAHRRLASALYAAGLFTEAEEHYGEALRLCAEHPGGEGVSLRASALRGLGSLHLAFGRIDDAVRTLQKAVDVRREAGDDAGLARARTSLARAHRKAGRIEVARELVTPQIAVFRRLGDVMWEITALRELGRLELAEGRLALATDHLEAARVLALRNHNRTGAVITLVALAEVDAAAGRSDAAAARFREAAEGFHAAEDRVREGTTQLKLALLLARTGAGREADAAAERARAVLTGLDVPDAADLWRRLAEMRGAAGATPSDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIQ3</accession>
    <name>A0A010YIQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="38"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="211"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="41652" checksum="C4DCADB8A01E02D7" modified="2014-06-11" version="1">MAGSSPPGHPEVTRGKAALLTLTGMRVAIITESYPPDVNGVAHSVLRTVEHLLARGHEPMVVAPTSLGEPRSALPDIPVVRVPSVGLPGYPSFRVGLPTRRVAGALHRFRPDVVHLASPFALAAQGAFAAARQGLPAVAIYQTDVPGFAGFYKLGAGRAAAWRWLRRVHGVTARTLAPSSATATELAAHGIGPVQLWPRGVDAVRFDPGKRSSDRFGTDEIVVGYVGRLAPEKRVDLLEPVTQLPGVRVVVIGDGPARSALERQMPRAHFLGEVVGEDLATAFASLDVFVHTGAHETFCQTVQEAMASGVPVVAPAAGGPVDLVRSGVTGYLVTPDDPGAYLAAVRELVADASLRREFGAAGRAAVAGRSWAAVGDALIGHYRDVVRGSSIAAPVERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMD5</accession>
    <name>A0A010YMD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipid carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850692.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169722_0_0_11"/>
    <dbReference type="OrthoDB" id="1792009at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="112" mass="12048" checksum="1504E7097190E07C" modified="2014-06-11" version="1">MATLEECRKALQDVADRIASGDTGDRQPPKLDRSLACRITDLGTGFHGRLAGGTIQNLTDGDDPKAQIALTLSSDDLVALSRGELDFAKAWVSGRIKVQAGIKDMLQVRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMV3</accession>
    <name>A0A010YMV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-dependent formate dehydrogenase delta subunit FdsD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850912.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2625"/>
    <dbReference type="HOGENOM" id="CLU_166802_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021074">
        <property type="entry name" value="Formate_DH_dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11390">
        <property type="entry name" value="FdsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="67" mass="7442" checksum="3CCDD8A25E125707" modified="2014-06-11" version="1">MSAVVPERRLIDDIARQFGHLPPDAAADAIADHVRRFWDPRMRARLLTLADDEGLDPLPAAAAARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN21</accession>
    <name>A0A010YN21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2679"/>
    <dbReference type="HOGENOM" id="CLU_044498_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="94"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="31174" checksum="15B44848569F0083" modified="2014-06-11" version="1">MTIVEQVAALVDEHYVFPAVGPRISAVLRRRLDEGAYAGLEPEALATRVTTDLQSVNGDRHTRLVFHADELPADHGDDAADAVRRGALAARWAGGVTRAELLEGNVAVVALAPILFPPAAAGESVGAAMTWARRSSALILDLRRCLGGDPRTVTLVCGYLVGDERVHVNSLRDRHGDLTQFWTSPALPGRRFGPERPVAVLTGADTFSSAEELAYDLQQLGRAEVIGERTPGGAHNRRAFRVHPHLEATISVSAAVNPVTGTNWEGVGVVPDVEVPAADALDVAHRRLRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN27</accession>
    <name>A0A010YN27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850990.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2684"/>
    <dbReference type="HOGENOM" id="CLU_046006_11_1_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14154" checksum="353E086DD71C75C9" modified="2014-06-11" version="1">MTQTVWPTLRARDARALIDFLVTAFGFEEVVAHSGDDGVIQHAELAWPGGGGIMLGQERDDPDNPWKLPPGTFGAYIVTSTPDALHERAAAAGAEILRKPFDTDYGSRDFAVRDPEGNLWSFGTYPGHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNZ3</accession>
    <name>A0A010YNZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851357.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2823884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="66" mass="6800" checksum="F88036EB668C0536" modified="2014-06-11" version="1">MSVPSSRCGRRPNTAPADAALSVASFVVFALTADVDDTQHRIAVADAVLPVLLGTATALPDRRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPJ7</accession>
    <name>A0A010YPJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851700.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3214"/>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_11"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="439" mass="47540" checksum="297C60A9C6E8C918" modified="2014-06-11" version="1">MTEQARHRVVIVGAGFGGLYAARALKRAPADVTLINGTNHHIFEPLIYQVAAGILSPGEVAVSVREVVRRQRNTEFVLGTVTDVDPSSRNVTVTASDGTTRRIEYDTLVVAAGATQSYFGHDEYATYAPGLKTIDDALEIRGRVFSAFEMAELATDRAEQQHWLTFAIVGAGPTGVEMAGQIAEIAHRTLPGQYRRIDPRQAHIVLLDAVDRVLPTFDPRLSAKAERRLRKIGVDVRLGARVVGLDELGVKVETVTGVESVEAMTKIWSAGVSGTGLAARLAEATGAPTDRAGRILVEPDLTVPGHPEIFVLGEAMSLDRLPGVAQVAIQGGRYAGRAIARRLKGGRASKPFSYFDKGNLAAVSRFFAIADLGRIRLSGTVGWLIWLGVHVWYLYGLRNKATVLLRWTISFLGRTRSEAVVTTQQVTARNALRQRASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPK6</accession>
    <name>A0A010YPK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851711.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3224"/>
    <dbReference type="HOGENOM" id="CLU_018204_3_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="234"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="39484" checksum="529AE42596A0243A" modified="2014-06-11" version="1">MNNGWTDDVDKAVAYAADRAAEAAAEVDRDARFPSEAVAALREGNLLNAAAPVEMGGLGLNPAELVTISTRLARACGATAMVWAMHQIHLACMVRHHPESAMVKRSIDEQWLVSSVASEPGIGGDLRSSRAGVGGGEGGSHTLVKQASAVSYGAHSQGYLVTARADEGAVAGNQVSVLVSREQTTLEQTGTWNTLGMRGTCSPAFHLDMVFDQDQILPVPFRDIAARTMVPMSHLLWAAIWVGLATEAVDRAIRASRAKSRGPAVADNPNLGLAHVRLAGLKAQLTAATLAADPVLVGDEEPTLALTVELNDLKIGVSEGAVDVVRLALGVCGLAGFGEAGPYSVARIMRDVLSGPVMIGNSRLVAANSQMLLMSGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPX3</accession>
    <name>A0A010YPX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3349"/>
    <dbReference type="HOGENOM" id="CLU_028518_5_2_11"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="30027" checksum="E40CCDB1941BB515" modified="2014-06-11" version="1">MSLTLDRAQEQSDVGTPPTRRRKLPPPGLLLSIGLVAFIVLAAFRPSLFASRDPLTGVPADRFSAPGASHWFGTDELGRDLYTRVVHGAALSLKATLIAVVVAFVIGGAIGLLAGFVGGWLEDVLMRVVDVQLAIPPLFLSLALVTALGYGTTKVAVAVGVASIASFARVMRAEVLRVRQSTYVEAAYSLGTRWYTILWRHVLPNAIGPIAVLVTLDFGIAILAVSSLSFLGYGAAPPAPEWGTLVSSGRNYLANAWWLSTLPGLTVAATVLATNRIARALDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ81</accession>
    <name>A0A010YQ81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348253_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21459" checksum="EBAF2B7D68B7EA8F" modified="2014-06-11" version="1">MPLIDSTQVRPRRRWYALAGVLPVLGIIVGVIAFVFGLWASVGVRPDVAVESRGGAESSASIVSSSTYWMVYVPRGTAPVPPCTASPATSVEVTPLRGDLFSYRSGGTRWEAQYRLVVTSPGYYTINCGGTPFVVADATRTANAAAFGTLGALGGLLGLPCVGLVAGFVAWLVVFLRRRGSRKRLELAVAHQPYGWPSTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQA0</accession>
    <name>A0A010YQA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852109.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3506"/>
    <dbReference type="HOGENOM" id="CLU_061391_0_0_11"/>
    <dbReference type="OrthoDB" id="1789233at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="27525" checksum="B84C84A60537AEA9" modified="2014-06-11" version="1">MTSHVPGKSLAAYARGELDDASSWTVEAHVDSCPVCVMRLGDMAGPDVEAMVDAGRAGIAAHWPVTAPVRRRAWQPAWRRWTSWSLVAPAVVTVLALLAAFVLDREYPDRPSLVLLLAPVAPLAGLALAWSHHGDPGWEAVAGTARAGLDLLLRRSLVVLAAVVPPLAVVGWALGRAPALWLLPCLTFTSATLLLGSLVGVSRAAAVLGGGWVLAIATPAVVAGVSPVLIQPASVPVWAVAGVLMPVLTLLRSGAMRRLNSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQE5</accession>
    <name>A0A010YQE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852200.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3559"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="31937" checksum="D8CDD971E731FE69" modified="2014-06-11" version="1">MTGILEGRVAIVTGAGRGLGRAHALELARQGAAVVVNDLGTSGSGEGASRTPAEQVAAAIRAAGGEAVTNGADVADFAAAEALVAQAVETFGGLDVLVNNAGFVRDRMLVNTSEEEWDAVVRVHLKGHFAMLRHAAAYWRREAKAGRPRAARVINTSSGAGLQGSVGQGTYSAAKAGIAGLTLVAAEELAPYGVTVNAIAPSARTRMTDGPFATKMAKPADGFDAMDPANVSPVVAWLASAEAGDVTGRVIEIEGGQICVEDAWRHGPAHDLGARWDAADVGPALRELLGRAAAPEPVYGARPAPAAQPDGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRI2</accession>
    <name>A0A010YRI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725733.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3975"/>
    <dbReference type="HOGENOM" id="CLU_124855_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="50"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="18883" checksum="61A7EA94B3C83A80" modified="2014-06-11" version="1">MAVLVAAVVVVGAVALANLVFTFGVVRRLREHTELLNRLGEGGLSGRNLLGPGRQAGPYTATAVDGTRVSGDGPDSPTLVGFFSLGCEPCTVKRPLFADAAREHPGGRDRVLAVVVGDDGDGDVSAYLDELTPVSRVVRELPTGELPTAFRVDAYPAFALVDADGTVLASGSAVPDATAIGTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRK1</accession>
    <name>A0A010YRK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457657" evidence="2">
        <location>
            <begin position="26"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="208"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="331"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="595" mass="62495" checksum="3903FB30B2226E32" modified="2014-06-11" version="1">MRSLGDLVTRRSLRPSVVATRRAMAVTAAVACTVGGLIGLLGMLVRPSNETDDVIRLASVASMLAGLALAKWGQRLPPLAFYLLAESAALLIAVSVWLQRDRPDAAAVAALLLLVTVFFFAFFDPVASLPGLVTVLGALAVIQVGWGALPWSTVLVLAGLNLLIAAVVGWLVRAAADSGLDVLTGLPNWRGLERAGHAALQRARHRGQPLTVALLNIDGFARINSTSGIAEGTRILRACGQAWATAVAPPAVLGRTAGDDFVLLVPGLGLGSVGPLLDALRAVAPPFVRFSVGVAGYAPGDAVRTLLNRADGALRLAKAGGGDRTVYARDDSADAQALVSGLDADEFRVLYQPIADARTGRVTGAEALVRWVRAGHGPVPPDEFIPLAERCGFITTLGEWVLRTACRDAAAWPRTLPSKVTVNVSGQQMQRPDYADHVLSVLAETGLPADRLVLEVTESTLQADSPCAIDALRALREAGVRIAIDDFGTGYSSLSRLQHLPADILKIDQSFVAALKPEDHAAPLVAAVTALAHALGLRTVAEGVEEHYQTVLLAHHGCDEVQGWLHGRPGEPARIGEALAEQERSARAAPTAVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRS0</accession>
    <name>A0A010YRS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sarcosine oxidase, delta subunit family, heterotetrameric form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852981.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4092"/>
    <dbReference type="HOGENOM" id="CLU_156359_1_1_11"/>
    <dbReference type="OrthoDB" id="1986447at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006279">
        <property type="entry name" value="SoxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038561">
        <property type="entry name" value="SoxD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04267">
        <property type="entry name" value="SoxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01374">
        <property type="entry name" value="soxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="81" mass="9457" checksum="E9FFF74BB8961C2B" modified="2014-06-11" version="1">MQLIDCPFCGPREEAEFSYGGQAGVAYPADPAALTDEQWAHYVFFRDNPKGRFVERWYHAIGCRRWFTAVRDTVTYRFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRW0</accession>
    <name>A0A010YRW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853038.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4129"/>
    <dbReference type="HOGENOM" id="CLU_046006_18_5_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="114" mass="12253" checksum="79AD6E5AB0D7CD46" modified="2014-06-11" version="1">MNFVSIRVITADVARLVGFYEKTTGLTATWATPEFATFTTGAATLAIGGERTVPVASPAANRSVIVEFLVDDVDALHGTLDDVEVVMPPTTMPWGNRSLLVRDPDGNLVNFFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVQ1</accession>
    <name>A0A010YVQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847729.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159575_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458912" evidence="2">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="26058" checksum="CD0C250D8139F1E2" modified="2014-06-11" version="1">MKTGFAHTLVAAALVLVTACNFSPTDPDPVPSTKPAPSPTQDEVDLVAALRRTQRVPHHFAVDADLPKDEHLTGSGEFDVTEQLYASSTGTLDRVVIGSDYYQRDPGARWVHVDLERLKEDSKLHFGMADATGLLQFADAITEAHKTGPNTYSGRFQPDTEDFKEPFLPIGAPSLWSIGMRVSPFTVTVDAKGWVIEVSMELTPTDSPTLRMEATLSAQGQPVSVEKPTAQEADEAFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW15</accession>
    <name>A0A010YW15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enterochelin esterase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569597.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.341"/>
    <dbReference type="HOGENOM" id="CLU_059519_1_0_11"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="31002" checksum="A49378E57DB33F57" modified="2014-06-11" version="1">MVSRRAVLGTGVAGLGLLAAGGVGLVGTGVVPGESQLRRALGACDVYAPDPEAQPGDVIGGEFRSAHRRAAVRYRIAYPPGFAVGSSLPVCLVLHGHGGDERVLGPEIALPGYLADVVADGVPAFALAAVDGGPRYWHPRADGDDPLGMLTDEFLPLLAGRGLQTGAGRRIGLLGYSMGGYGALLFAELNAARVAACAVGGPAIWRSYADARRESASAFDSAADWSRYDVLAHGAALAGVPVRVDYGTHDPNAAVMPAVKAAMPEARVRESPGCHDATFWRAKAPGALTFIGRAFAQVPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW94</accession>
    <name>A0A010YW94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079635_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20540" checksum="0657B8BB06B78FEC" modified="2014-06-11" version="1">MNPQVGYPSHAPSGPAALPAPSRPVDRWLARVIDGTILFVPIVLLFVVLFGIPLFLSLASSEGNGASEEGVLLWMLVAVLGYAVATAATGLLTYWYAVKYQFRNAGQTLGKRWRRIRVVSVDGAAVTASQARKRWLASDGVSALGSIPFLGALLGVYVLLDNLWLLWDKPHRQCVHDKFAKTIVVKAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY02</accession>
    <name>A0A010YY02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848866.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1124"/>
    <dbReference type="HOGENOM" id="CLU_139202_1_0_11"/>
    <dbReference type="OrthoDB" id="1963330at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="13619" checksum="EBA474BDB6BAF068" modified="2014-06-11" version="1">MNLEASLKEAMNIEGAIGVALIDYNSGMPLGTLTSVSDLDLDIIAAGTTDFVRAKMRTLELMRLEEPIEDILVTLVTQYHVIRPVTSRSGKGLFMYLMLDKTRANLALARHKLTRIERELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY37</accession>
    <name>A0A010YY37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">egtA</name>
        <name evidence="5" type="ORF">CryarDRAFT_1188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2 3">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569802.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1168"/>
    <dbReference type="HOGENOM" id="CLU_037109_0_0_11"/>
    <dbReference type="OrthoDB" id="991285at2"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017901">
        <property type="entry name" value="GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03444">
        <property type="entry name" value="EgtA_Cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="47656" checksum="C8758F15CB4F1F97" modified="2014-06-11" version="1">MSETTIRSSRASTSRIEEPLDEPIRTRADAEAFIAKICFKIGPPRLAGIELERLVHDANDPTAILPVERLASALGSWSPPVLTTPTADPTALGRPLPAGSTVTVEPGGQVELSTQAWGTFADCLSAAGTDADALRGALARYGLAVGHSGIDAHRPATRIVQKARYAAMERYFDRGGAAGRLMMGSTASVQLSVDAGTEDGEHAMVDRWRLLHAVGPTLVALFANSPLYAGAPTGWHSTRQRVWITLDPGRTTAVNAAADPRAAYASAALDAGLLCLPNHTDRWDAPPGVTFADWLDGALDRPATYADLEYHLSTLFPPVRAKGFLEVRYLDAQAGDDWRVPPAVLWTLLSSARVRDAALAAVERTGEPTWPGAWARAARDGLTDPNLARAASDLMTLALENAEPAGVPSAGVRTMLRFAERRTFRGRTPADDQLDDFAHSFDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY91</accession>
    <name>A0A010YY91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Propanediol dehydratase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848980.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1225"/>
    <dbReference type="HOGENOM" id="CLU_022314_1_0_11"/>
    <dbReference type="OrthoDB" id="118959at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010254">
        <property type="entry name" value="B12-dep_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003208">
        <property type="entry name" value="Dehydtase/Dehydtase_re"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036999">
        <property type="entry name" value="Diol/glycerol_deHase_lsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003206">
        <property type="entry name" value="Diol/glycerol_deHydtase_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02286">
        <property type="entry name" value="Dehydratase_LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02288">
        <property type="entry name" value="Dehydratase_MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52968">
        <property type="entry name" value="SSF52968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydratase_LU" evidence="1">
        <location>
            <begin position="4"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="741" mass="78117" checksum="76282489F08C3512" modified="2014-06-11" version="1">MAVGRIRRLDAQPVNLDGFAVENADLGLIALRSPHDPAPSLRLEDGRVVELDGVAEDDFDTVDAFIAAHGLDLSVAPEAMALPDVELARLFVDFAVPRAEVVRLVSGCTPAKLARVLALLRPAELMMAMTKLRARRTPSNQGHVTNRADDPLLLAADAATAAAYGFRELETTVPVLADAPSNAVAVSIGAAVGAAGVLVQCSVEEALELELGLRGFVSYAETVSLYGTEGVFTDGDDTPWSKAFLTSGYASRGIKMRVSSGAGAEVLMGGAERRSMLYLESRCVALARAIGAQGVQNGGIDGASVAAAVPAGVRELMAENVMVMARNLEACTGNDALMSESDVRRTSRTLPILLAGSDFVCSGFGTIERYDNMFGPSNWNAEDLDDWLAMQRDWGVDGGLRTASPDSLEPLRRRAAEAVQAVYRWFGLADLSDESIDAAVDAVGSKDLVGDDALAVLNAARTIRESGLSMVDVVTALAESGFEEEASRILSMLKARVVGDYLQTAAIFTPSMDVLSLVTDPNDYAGPDTGYVPTPSRQAEIDDIRQARSVSDLRAEQASWASSSISSTGPAVVGSDPREVVVGVSPATGREIWRTLSGLLVVDVLQEILAGLEEEGALGRVVRINDTLDLGMIGLSAARLAGSGVSVGLQAKGTALIHRRDLPPLANLELYSVAPVLSRADYRLLGVNAARHARGAVPEPAKNPYTDEAIEARYHTAVVSLIAVERGCCAPVGPDELKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYY0</accession>
    <name>A0A010YYY0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849300.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1475"/>
    <dbReference type="HOGENOM" id="CLU_082566_0_1_11"/>
    <dbReference type="OrthoDB" id="1643056at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="23327" checksum="4642199D95E65B43" modified="2014-06-11" version="1">MSEVVSVNIGVHRVVPWTQSMGSTGIDKRPQPGRVRAVGVGLEADVIVDTKNHGGYDQAVYAYASEDADWWEQELDKQLWPGAFGENLTTRGVDCTGAVIGERWRVGSTVLEVSCPRIPCRTFAGFWDVPHLVKRFTEQGRPGAYLRIVDEGDLGAGDAVEITHRPGHGVTIGEVFRALTGERSLAARILEAPELPESIQHRAQRMLSLTQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z035</accession>
    <name>A0A010Z035_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinuclear metal center protein, YbgI/SA1388 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569961.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1861"/>
    <dbReference type="HOGENOM" id="CLU_037423_1_2_11"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="28671" checksum="73F26ACB68A09CD7" modified="2014-06-11" version="1">MVTISDVTTVFDRLYPPELAESWDAVGLVCGDPSAGVRKVYFCVDVVAATVDEALEWGADLLVAHHPLLLRGVTAIPASTPKGRTLHRLIRAGAGLFVAHTNADSADPGVSDALAARFDLRDLRPLHPRPDAANLGIGRIGTLPEPLTAADLTALAARVLPATPGGVRLAGDPGRVVRTVAVSGGAGDSYLGDATGAGVDAFLTADLRHHPASEHAESGGPALLDAAHWATEQPWLAQAAAALVSSVGPATVETFVSDLVTDPWTRAVVPDHPREGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z156</accession>
    <name>A0A010Z156_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein with HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2236"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="34311" checksum="9F51AAE9CBA00CF4" modified="2014-06-11" version="1">MLARGARHSRDHPGFASRAARDDVWAPALTPQEAEIAALASEGLSHPEIGARLFITRRTVRYALRKVVAKLGITRRFTNRSPLRDPLRYPSAPPTGVLMIRNVVLVHGAWADGSGWRAVHDLLTADGYSVSVVQHPTVSLADDAAITRRVLDQQDGPTVLVGHSYGGAVITEAGTHEKVAALVYVAAFAPDQGESVNTLIADPPPGAPTPPILPPVDGFLLLDREKFPAAFAADLPADDARFLADSQLPWGLEAVGGPITEPAWRSTPSWYLVAGDDHMIPPVAQRAMSERIGATVTEVASSHAVYVSHPESVVALVRAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1P9</accession>
    <name>A0A010Z1P9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">CryarDRAFT_2454</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850633.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2417"/>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_11"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="126"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="246"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EXG81343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="42579" checksum="593B866F7D78F854" modified="2014-06-11" version="1">MARRLFTSESVTEGHPDKIADAISDGILDALLAQDPRSRVAVETLITTGQVHVAGEVTTDAYADIPSIVRETILGIGYDSSKKGFDGASCGVSVSIGSQSPDIAQGVDTAYEARVEESEEDALDRQGAGDQGLMFGYANNDTPELLPLPIALAHRLARRLAQVRKDGLIPYLRPDGKTQVTIEYDGPKAVRLDTVVVSSQHASDISLETLLAPDIAEYVVAPELAELGLETEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIVDTYGGFARHGGGAFSGKDPSKVDRSAAYAMRWVAKNIVAAGLADRAEVQVAYAIGKAHPVGLFLETFGTETVDPDRITKAVNEVFDLRPAAIIRDLDLLRPIYRQTSAYGHFGRELPDFTWEKTDRAAALKDAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z213</accession>
    <name>A0A010Z213_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="342"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="475" mass="50513" checksum="D3A627880F5927E2" modified="2014-06-11" version="1">MAGYLVVPDHPALNGWLVTGYKTVFGCVAGGALVAGALARRPRALAGWLIFGVGIIANSLGALISDVYTKALGQVGYPNIADLFWLTLYPSLFLGLAVLIRARGTARDWASMVDALILACGLGLLSWVFLMVPVRSDHTLHTIGQVIVLAYPVGDIMVLVMLLHLVLSGGVRNASFWLVCSSMGLFLAGDLSWATLSQLSLVPSDFTSRLLDLIFLLAYTTFAFAAWHPSMGALSRLGTVKPPRLTLLQLALLTAATMIAPTVLAFQVAHGEVTNGVAIVIGSVASFSLVVARMTQLVRQVERQADELTALARRDPLTGLPNRRAWFDDLPDALARSARGAEPVTVAMLDLDHFKAYNDGHGHQAGDQLLKGAASAWSGELRAVDHLARYGGEEFIVFLPGTGADRAAEAIERLRAVTPSGQTFSAGLAVWDGLETSDELIGRADRALYAAKANGRNRTELSGETSASVDIGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2F9</accession>
    <name>A0A010Z2F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851007.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2693"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="33068" checksum="B233B87E16B87C66" modified="2014-06-11" version="1">METVLAVDLGGTTLKCAVFDATGAPLWAARHPTGRERGADAVVSTVLEVLTSMRERAVASGWPPRAIGLAVPGLVDAAAGVAVWSVNVGWRDVPLRDLVEARVGLPTVLSNDVRAGGLAEAAASGSDDVLFVPIGTGIASAHVVAGAVVTGASGAAGELGHVVVRPGGRKCGCGRRGCLEAEASASAIEARYREAGDSVQSGGSVQSGGSVQSGDSVQSGGSVPAAISAAGASAAEVARLAAAGDPVAAGVWGEAVEALADGLVSAAALLDPRVIVVGGGLARAGETLFGPLRAAVSARGSFLPAPEIVPATLGDEAGCHGAALLARPLLAGVSGLPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z309</accession>
    <name>A0A010Z309_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570190.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2870"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="351"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="53354" checksum="419D9F5EFCA6299E" modified="2014-06-11" version="1">MRIRRENVWLAFLAGGAAGVAGYRLYPLSGGPTLPHDELNIALTLAGAVAAVFGIRLNRPGARVAWALIAASQFMIFLGCLPTYLPPLFGDAKPAFLGALALIFAVQYPLLALGLVLLIRRRTPSMDRAAALDAGIVTVSAALLSWVYLIYPLTGDSTLSVVDRAALVAFPFGDLLLLSIGARLVLGKGVHPPSLWLLAGSLIAFTAADTLQSVESLAGEELLGGYWPETAWLVASILLGASVLHPSVRLVEEPSPAVVAEAGRYRLALLAVASLLAPATLLVQYLRGAPQHIPLVCTACALLFLLVLARMGGLVAAQREVAITDGLTGLHTRRYFQHSLVMEGERALRGAGLGVLLIDVDHFKSVNDTHGHHGGDRVLREVARRLYVATRGGDLLARYGGEEFVVLLSNTTPPIAREVAERVRRTIADVPIPVGPATSATVTVSIGVATMPEDTTTVDDLLALADELLYASKTSGRNRVTTTAGSPPPVDATGPPRRAEKVAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z313</accession>
    <name>A0A010Z313_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851238.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2875"/>
    <dbReference type="HOGENOM" id="CLU_047561_0_0_11"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="56"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="291" mass="31173" checksum="A1FD8F83AF7D0B4E" modified="2014-06-11" version="1">MSGERVTLTDAPRYAPTWLELREPADAEARSRDLLVPLRRHLAETLATRGSLLIRDLGCGTGSMQRWLAPQLDGPQRWILQDHDADLLAFASANAAEAAADASRVTVMTRHADLTELSPGDLRSTSLITASALLDLLSVDEIDRLAATCVEAGCPALITLSVTGAVDFSPADPLDEELAAGFADHLRHHVEGRELLGPDAGGAAADAFTRRGWVVEQRSSVWRLGAAHADLTAEWLRGWVPAAAALRGHDAEDYLTRRLDALATGDLRVTIHHTDLLALPHGATTMLGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3J8</accession>
    <name>A0A010Z3J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606523_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="316"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="451" mass="47552" checksum="58FED8F65940A638" modified="2014-06-11" version="1">MTTAWRGRLAAGLVVLLAVAVVASAGLYLAQVQRDARHSIVEDFDTRARLAAGVSGDTVTASEEKTREWAETMFAGPVSGLAPILEVQRSGITWLAVLDADGAVLSASPPGISTLAASLLTTRGYRLALTRDKLTYGDITTQTGVDMVYAFQPFAAGDGQRVLVVPATVNELATILRSALDVTGSRTYVVDSSGATIVATSGRLDPELAAAARTDGRGVTASGDYYLALPVDGTAWRMIITKPRAELLAPVKETTRVAWLIFAGFAAAVTVIIVVGALTLLGSARLAHARLHDTLTGLPNRALFLERAAAAIAQRHAVTALFLDLDGFKPVNDTYGHAVGDKLLAEVGKRLVGATRAHDLVSRFGGDEFLVLCRGDATAVAARIHDQLSQPYEIDGHTLRVGVSIGLATLEGDADSAETLIHHADLALYEAKRGGRGRIERFEPRLASAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3Z8</accession>
    <name>A0A010Z3Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851699.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3211"/>
    <dbReference type="HOGENOM" id="CLU_007383_5_2_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="25722" checksum="B808831FAFFECCA0" modified="2014-06-11" version="1">MKIVVVGGAGRVGRSVVANLRDQGHEVVAADITTGFDTITGTGLDAALEGAAATLDVTNSPDMSEGPATDFFRTSTRNLLTAESKAGVGHHVTLSIVGVDRPHELGYYRAKLAQEQAVHEGDVPYTIVRSTQFFDFLAMLVDNSVEGGTVRLPGTLVQPIAVPDLVNALATTVTGPAAQGIVEVAGPEAMAFDEFARRLSAVRGDERTVVTDPSATPFFGVPLGERLLLPGAGAKLGNTGLAEWSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z418</accession>
    <name>A0A010Z418_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851729.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3232"/>
    <dbReference type="HOGENOM" id="CLU_108696_16_4_11"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="96" mass="10348" checksum="58857DD4340BDAFB" modified="2014-06-11" version="1">MSTVPEQTERVSADVVEQELGAYLRERLNTPVPNDTDLFAAGLVNSMFAMELVVHLEGTYGVAIVGPDLRLDNFRTITQMAALVQRLSAAPDGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5X9</accession>
    <name>A0A010Z5X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852656.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3892"/>
    <dbReference type="HOGENOM" id="CLU_054222_0_0_11"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="41729" checksum="BC7A3021FF98FA89" modified="2014-06-11" version="1">MRVLLAQNMRYRPGHGGATKSNRIWLEQLAAAGHRCVAVTPGDADAVRVDNGVEVHTVSTGARLAPAVVAVAAAERPDWTLVPSDDPGLVMLGTALRATPGRVVYLLHTLQQAPFGPRSFYPGGSGAALVRRCAAVVAVSRTAQEYAARWAGLDATLIHPDVYGSGPHPRLGRPDAGAVTLVNPCGIKGLDVLLGLADAEPDVPFLAVPTWGTDAAERAELARRPNIALARPVDDIADLLARTRVLLMPSLWDETFGYTAVEAMLHGVPVLAADVGGLREAKLGVPHLLPVRTIEAYRPQRADEPYPRPVVPPQDVTPWRTALRRLLDDPAGYTALADQGRRAAAEFVAGLDARALERCLAGLTPAPARPATAPDPVRQRALAALLARRKVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6E1</accession>
    <name>A0A010Z6E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine/D-amino acid oxidase, deaminating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4039"/>
    <dbReference type="HOGENOM" id="CLU_007884_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="18"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="384" mass="40867" checksum="DF0AF52D752FAD0F" modified="2014-06-11" version="1">MAAPSARSSVTAMTQSFDVAVVGLGALGSAAAYQLARRGVNVVAFERFELGHVRGASHDTSRILRTSYGETRYVRLAQSAYRDWADLETVSGEKLVTTTGGLIFAPAGGPYSASAFVSSLTETGVPYEELTPDEVHARWPQFRIPAGVETIWTGDSAIVHAARTVAVLQLQARVSGAELRANTPVTAVRPGPDGVLLETASGPVRARKVVLATDAWTNELLAPLGAEIPLVTMQEQVTYFKPADPAAYDPARFPLWVWLDAHCYYGFPTYGEPTIKAARDVSNNYMTPDERSFEPSAALLSELTEFMHATIPGSGSALRTVTCQYALTADREFVLGPLAGYPDVIVALGAGHAFKFTPAIGRILADLALDGATTDDISAFSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKY4</accession>
    <name>A0A010ZKY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic component of the Tol biopolymer transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.301"/>
    <dbReference type="HOGENOM" id="CLU_579669_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459082" evidence="3">
        <location>
            <begin position="38"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="48727" checksum="D40C66F539FB626E" modified="2014-06-11" version="1">MRKRPVFVVLAAVLVAVLLSVGAGLVAALLVGTGDDAEEFATPSYPRNAESLPTLISDVSESAPGRSIVLAETTGAFTDGHVLFAADSDRVRDVSAIEDRVNSDYGAATTRLSPDGRRLAVGDLSGKFDDILVLDLVTGASQRFSVGGGSTEVLAWSPDGRRLAISSEALDVLDLDTGSVKRVATPSTNATPKTDLLPGEAPMPTGGGVAPKTVDGMTKIQAAFSPDGRSIAYDDGVDIEIYPLDGAGPVVRLTDKAVWLAGASAWSPDGRRVLVTREETNDVNGATSLLAIDVATQNATRLVTFDYIDFSVPIPVGWRSASEVLLSGTDADGAFVVQAYDVDAKRRGDRLMTFGYSTYSAEFASGLIGSAVGRDGDFSGGPTPTWWRAVVGVVVGAVVAVVGAIVATAVGVPMVLRRRSAARRVAPPLPVPAGGGFVPPAYVHLVPGPVPVVPRVSGPGPASASDWVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL03</accession>
    <name>A0A010ZL03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725642.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.327"/>
    <dbReference type="HOGENOM" id="CLU_027938_4_4_11"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="30350" checksum="5D8568DB3A30A856" modified="2014-06-11" version="1">MAEIVYPPVITLAKAAFAGIRVKVDEVGGEHIPRTGGAVLASNHVSYLDFLFCGLAAQPSKRLVRFMAKESVFRHKISGPLMRGMKHISVDRAAGAGAFAAAVKALRDGEVVGVFPEATVSRSFLLKDFKFGAARMAAEAEVPLVPMIVWGTQRYWSKENPRDLTRRNNPVLLRVGEPLNPTKSDDPAEVTAEMKSRMAVLLEEAIESDPYRPKGQDDKWWLPASKGGTAPTPEDAAILEKAEVEERIKQARAQARVVAEARVKARAKAKAKAAAKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM77</accession>
    <name>A0A010ZM77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848514.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.777"/>
    <dbReference type="HOGENOM" id="CLU_040923_3_0_11"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="31442" checksum="295428C07593450A" modified="2014-06-11" version="1">MTQPRRKRSIRSATVLRTEQLTPHMVRVVLGGEGLAEFPAGEFSDHYVKLMFPQDGVDYPEPFDMDVVRETLPRETWPRVRTYTVRSWDAETGELAIDFVVHGDEGVAGPWAAAAKPGDRLLFMGPGGAYVPTEDADWHLLVGDEAALPAIAASLERVPAGKPAYAFIEVAGPEEEQKLGTDADAHVVWLHRGDRPVGDALVEAVRALEFPAGAPLAFVHGEANFVKELRRYLRVERGVEREQLSISGYWRRGRDEDGWQSSKAEFNARIEEEEAQALATSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMZ7</accession>
    <name>A0A010ZMZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848847.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2116938_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="114" mass="12791" checksum="CCE49A9D5C3763DE" modified="2014-06-11" version="1">MTEPSGEWTALERRVSVLEERMDVESGFRIGIERDLDKITQRQVAQGQLLQALALTQSEHTERLSRIETKLGSYETRMGALEMKVGALEMKVGSLEGGVNRIIGMLDTLISREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNG1</accession>
    <name>A0A010ZNG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849030.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1270"/>
    <dbReference type="HOGENOM" id="CLU_031285_7_0_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459190" evidence="1">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="462" mass="48208" checksum="58A8516AD45B8839" modified="2014-06-11" version="1">MTRPGLIAALLAAVLTTTVLAGCSGDNSSDDDGTLTVWSLENQADRVAATQKVIADFTRSTGIEVKYVGVDENQFSKLVTAAAAGGDLPDVMGALPLAALWSLDANELLDTGSAGEIVESLGADTFNRRALALAKDGGKVLGVPSDAWAQLLFYRTDLFTKAGLTAPTTYDAIAAAAKKLTSGSQVGITAATVANDGFTAQTFEHIALGNGCELVDDGGKITVGSDECVGAFEFYDDLIKNASVKGAQSVDSTRATYFSGRAAMVIWSSFLLDELAGLRSDALPNCPQCKSDPAYLAKNTGVVTAIKGPDGRQPAQFGEVVSWAVSATAQTANAKKFVEFMMGDGYTRWLGQAPEGKVPVRTGDPTNKTAYVDAWRKLPAGVDKKAPLDTVYPAALVDQLASSVDTFGRWGIEQGEGRLVGATLGELPVAKAVNSMTSGQLDPAAAAEQCQEQVDDIKKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ46</accession>
    <name>A0A010ZQ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bile acid beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725643.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.335"/>
    <dbReference type="HOGENOM" id="CLU_010759_0_0_11"/>
    <dbReference type="OrthoDB" id="139229at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydr_116N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DUF608" evidence="1">
        <location>
            <begin position="486"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="813" mass="88411" checksum="0AF959FBCD3BFA8B" modified="2014-06-11" version="1">MRTYTGDERRAVAFPLGGLGAGHVALGADGALRQWQLRSTPNHRGFLPDSFFALRVSSIEPPDDVCRLLRSAPIAPHPDPAPNVDDDHVPDAGNLPPWPPVTGTTFTAAYPFANVTYHDETLPVDVRLSAHTPFVPLDADASGLPLVSYAFTIHNRSRELRHGWLIASLQNGVGWDGVAPIDGVRSSGYGGNVNRRYRRQGVVMDNPTLPDDDPRAGEMLLWADRPAAVLPRSGGAAETLRFAEAVKLVTPVQLWDFSRARIDEALKSIPPTLTGGEGPSPAGQTWDAVLAIPFALAPGEDTTIEVVHAWYFPNRYVDWDQFGPERPYGKSKLWLGTHYATRFGGVLDVLDHYRANPVASRAWSDAVETLPEPLADVISAQGTLVRSPTIFRTEDGVVHGFEGGLGASTRNFNGDVGGSCPVDCNHVYNYEQALSRLFPQLGATMRDTEWSIAAAEGYLPHRAVLPTWLPQLHGVEIGGPAKPALDGMLGAVLKTYRSVRDGAGLDWLRGHWPALRTLLAYVRDTWDADGDGVLQGEQPVTYDIALHGPNMFVGCLWLAALRAAEDMGRLLGENAVADADRALFELASTGYDELLWNGEYYAQPPSGEAYDFGAGCLSDQLFGQWWANQLDLGHLLPAERVRTALAAIVRHNLRTGFEDHGYRVFADGDETGLVVCSWPRGGRPEVPLRYCDEVWTGVEYTVAALCLAEGLHTEGGNVLAALRRRHDGSRRNPFNEVECGDHYARAMAGWSVLDAVTGFRYNAATRALRVGAHDGTYPFVAGTGWGTFTVDGEHVTLDVRGGTLPTSSVEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQC0</accession>
    <name>A0A010ZQC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CryarDRAFT_1964</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849983.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1928"/>
    <dbReference type="HOGENOM" id="CLU_050668_0_0_11"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="271"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EXG80869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="354" mass="39125" checksum="DFA12258E20392FB" modified="2014-06-11" version="1">MSESHGSGTEVEFDPTDPKHSQFDLVREGARRDGVEIVHYQPRFAVAGTKREKRVERTIAFLLALTGLSALAFVVIYVAWPYEYEQGYHADKLYTPLLGFTMGVALFSLGAAIIVWVKKLMPEEVSVQDRHDNNPNLDERALTAATIMNMVDETGIKRRPLLKGALALGAAPLGIMAIMPLGALIKDPHPDGETSPLWTTGFKEGVRLVRDDGTPIRPGEVSAGGLETVFPGIPHGTGLQYADSPTLLIHLREEDAAEFKPRKGYENAHYGNYFAYSKICTHAGCPASLFEQQTNRLLCPCHQSQFDVKDSCRPIFGPATRRLPQLPITVDEEGYFVAQSDFKEAIGPAFWERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQC1</accession>
    <name>A0A010ZQC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.421"/>
    <dbReference type="HOGENOM" id="CLU_1080235_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="25210" checksum="D796E5FA74CF3549" modified="2014-06-11" version="1">MSRRPGSDDPADGEIRGLPPEWGTIVVPDDLRDLSNEVATIQAELATHRPRRRRSRWLGRPGLSGPLCALILFLVAAIGSLMVIVLPKPSRPPRREPLASPSVAVGVAGGLVPALSLSGDGGRNASLREFRPAVLLISPAGCTTCAAVRNQLVTATDETQLTVVWVTESKQAITLIPGLPTGRLISLADPAGTARASIAGVSATGPSAVLIRTDGRIRRIEANLGDPFQLRPELAALANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQD6</accession>
    <name>A0A010ZQD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar diacid utilization regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569621.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.441"/>
    <dbReference type="HOGENOM" id="CLU_017436_3_0_11"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="302"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="557" mass="60131" checksum="BC0BDD51A6C335F3" modified="2014-06-11" version="1">MGRIAKDGRGPSANLTASPVGLPLRDVLEASTLTGARVLAGEGGLDRVVQRLNVMEVPDILPWVKPHELLLTTGYPLQHSTIALLDLVRELDERGLAALAVKLHRYLDELPAEVLAEADRRNFPIIEVAESVGFDDILNEVLSALLHRQASVLARSDEVHRALVSVVLEGGGLDDLAAELTRILGGPVIVTTPDGRVNARAGDVEDLQKTGCFDPTGRFRVDDEPTGVRPHDGGFHTTVPIVAGRIDHGRIVAFSDTPLDAADVYSLERAATVAALAVTKQLAIDAVEGKYRADFLRDLLTGRVEDVPAAVAHARTLGWDVERPLVAVVAELDPVTTPVGAAPELRPVQERFATAWQSVVRWRDPRAPVVNFNQEVVVLLGLPSGGGGADAVERAVGELVRQVVGDGGGGRRSFSLGISRPASAPHELPRAYEQARKAVRIGRRLHGDGARASFDRLGVHRLLSLIPDTSELRGFVEEVLGELAADTPENADLRRTLAVLLETNCTVAEAARRLHFHYNTLRYRITKLEKLVGPFTDDAALRLDLALALRVLEIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR08</accession>
    <name>A0A010ZR08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.674"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_11"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="PTHR43149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="30486" checksum="C25935A430B722D6" modified="2014-06-11" version="1">MSSPTDVATPYEFDEKLTALSATRHGEHGAVVRVTLLGPGKGNAMGPAFWSETPTLFRALGADESVRAIVVTGSGHHFSYGLDLTSFATGAGSTLQEDGGLARARTRFLHEIREMQTALDAVADCRKPVAAAVSGWCIGGGIDLLAACDVRYAGTDAKFSIREVRMAIVADMGSLARLPGILSEGHLRELAFTGRDIDAAKAERIGLVNEVAADPVGAAHAFADEVAANPPLVVQGVKEVLDVNRAERVAAAQRYVTTWNAAFLPSHDLTEAMTAFLQRREPKFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRM4</accession>
    <name>A0A010ZRM4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.905"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="62"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="604" mass="69162" checksum="89426A94DC9EB3A0" modified="2014-06-11" version="1">MTISLPHPPRLRAHTPDRSVETAAAHLHTSDGHLVEPQSESFKHARQLPLDPEWYKRAVFYEVLVRAFYDSSGDGTGDLDGLTAKLDYLSWLGVDCIWLPPFYDSPLRDGGNDISDFKAVLPEFGAVENFVTLLDETHKRGIRVITGLVMNHTSDQHLWFQESRRDPEGPYGDFYVWSDDDSKYADARIIFIDTESSNWTYDPVRGQFYWHRFFSHQPDLNFENEAVQEAMLDVLRFWLDLGIDGFRLDAVPYLFEEEGTNCENLPRTHEFLKRCRKTVEDEYPGRVLLAEANQWPADVVEYFGDPSVGGDECHMAFHFPLMPRIFMAVRRQSRFPISEILAQTPEIPEGAQWGIFLRNHDELTLEMVTDEERDYMYTEYAKDPRMRANVGIRRRLAPLLDNDRNQIELFTAMLLSLPGSPVLYYGDEIGMGDNSALDDRDGLRTPMQWAPDRNAGFSVCDPGRIYLPVIMDPIYGYQVTNVEAQLGASASLLHWTRRMIEIRKQHLALAVGTFTDLGGSNPTVLTYVREYVGADGDHDIVLCVQNVSRAYAPVELDLGRFRGCTPVELTGRVHFPPIGELPYLLMLPAHGFYWFQLTPYEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRN7</accession>
    <name>A0A010ZRN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Penicilin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848659.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.917"/>
    <dbReference type="HOGENOM" id="CLU_011790_0_1_11"/>
    <dbReference type="OrthoDB" id="186419at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459219" evidence="7">
        <location>
            <begin position="23"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="877" mass="95088" checksum="D9C9F966C269A25E" modified="2014-06-11" version="1">MNVARVLRRIGLSLLVVLVVVASVAGGTVYFTIRASLPDYTGTVRVPGLDADVQVYRDAQGIPQVYAQNADDLFRAEGYLHAVDRFWEMDFRRHVTSGRLAELFGPSQVSTDKYIRTMGWRRVAEQELPLLSAESRRWLQAYAEGVNAWIGEHSGRSAGLEYAVVGLQNSGYEIERWTPVDSLSWLKAMAWDLRSNMGDELERARLLASGLDWEQINELYPAYPYRSNPPIVTSGAVVDGTFQPTAVVPQEREGAPPTRRTAGGGGGSPETGDEAAVRAALRGLGGRLDTLGAGLGSLPQLLGTGEGIGSNSWVVGGSKTATGKPLLANDPHLGPAMPSVWYQVGLHCTTVGAACPFDVSGFSFSGVPGVVIGHNARVAWGFTNLGPDVTDLFLERVRGNTYERDGEQVPLVTRTERIKVAGGDDVTLTVRSTVHGPLLSDQDEDLRAIGAKPGVDAQGVPTQEPQTADPAYAVALSWTALQPSRTADALFTLNRVANFTEFRAAAKLFAVPAQNMVYADVDGNIGYQAPGTIPIRGSGDGLFPAPGWNPSYDWVGTVPFEQLPYTYNPPAGYIVTANQAPVREGAGPVLGYDWDTGYRSARIDALLQAKSAAGPVDADDMSAIQMDSWSAAAAELVPVLTKIGDVPASARAARDLLGRWDLHQTQSSAGAAYFNAVWRHLLRRTFDELPDDLTPDGGGRWFLVVSNLLRDPDSPWWDEKGTSAVEQRDDVLRDALTDAADELTGRLGDDVSEWRWGDLHTLTIRNQSLGTSGIGVIEALFNRGPYPVGGGSSIVDATGWTPAEGYEVSWVPSMRMVVDLADLDRSRWVNLTGQSGHAFSDHYTDQVELWRNGRTTPMRWDREEIRRGARYVQKLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRP1</accession>
    <name>A0A010ZRP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-aminopeptidase/D-esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570050.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2357"/>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_11"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="38237" checksum="2FE145DCF0F25A3F" modified="2014-06-11" version="1">MADHLLSTPSGRPRARALGIPLAGTPGRWNAITDVAGVEVGYTTLVEGESVRTGVTAVFPRGRDGVGVPCAAGTHSFNGNGEMTGTAWIAESGALNSPIVITNTAAVGPAHAGVVEWLKRNRPELTTQWALPVVAETYDGRLNDLYGGHVRPGHAVAALDAARIGPVEEGSVGGGTGMICHGFKGGSGTASRVLGYGPDHYTVAAFVQANHGARHELTIGGTPIRFAEPSGAPEPPPAAPRGAGSVIVVLATDAPLLPGQCGALARRATLGIGRTGTTGSHFSGDLFLAFSTANAGALTSTFPAGPVGDDEYEHLRFVPWGRIDAFYEAAVQAVEEAVLNALVANDDMTGFRGSHVPALPHDVVRGAFSAPGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRT4</accession>
    <name>A0A010ZRT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725703.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2423"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_7_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="173"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="353" mass="38389" checksum="AD66EE808A549F31" modified="2014-06-11" version="1">MTGHAADVSGGSVARGSDGVILVVDDDTDVAALVAMNLRFERFDVVTAHDARGALAAIERHRPDLVLLDVMMPRVDGFELCRQLRASPLTAALPIIMLTAKDLSADRIQGLTAGADDYIVKPFDVTELVARVKSTLRRNREMRDVSPLTGLPGNTRILEAISERIVARQDHGWEYAVCYVDLDNFKTVNDVYGFYRGDQMLTAAAGALHSSTIGVAGSPPFLGHIGGDDFLVVCTPEQVRPITDRAITLFDQASRVLYDPADLARGYFEVADRQGRLRRHGLLTLSIGVTVSTQRQFDDHRAVVAAASEMKSVAKRTEGSMVAIDRRRDPEPGRGPAARHQAALQPLPDPDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRV7</accession>
    <name>A0A010ZRV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ORF">CryarDRAFT_2490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850686.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2453"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_2_11"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="475" mass="51198" checksum="4BDB613B9E64ACDE" modified="2014-06-11" version="1">MTDTETTRLWGGRFSGGPAEALARLSVSVHFDWRLAPYDLAGSRAHARVLNRAGLLTADELHLMLKALDELEKDCADGAFTPTIDDEDVHTALERGLLERLGALGGKLRAGRSRNDQVATDLRLYLRDHARGVAQGLTDLATALHEQAETHKAVPAPGMTHLQHAQPILFSHQLLAHVQSLLRDLDRLVDWDKRAAVSPLGAGALAGSSLPLDPEAVAKELGFTRNAENSIDAVSDRDFAAEFLFIAALIGVHLSRLGEEVVLWTSQEFGWVTLDDAYATGSSIMPQKKNSDIAELSRGKSGRLIGNLTGLLATLKALPLAYDRDLQEDKEPVFDAVETLGLLLPALTGMIATMQVHTDVLEKSTPTGFALATDVAEWLVRKGVAFRDAHEIVGAMVAKAAQRNDELDDLTDDDLAQVSPHLDPSVREVLSVEGALRARTTPGSTGPEAVAVQLTNAKTAIAGFTDWAQEQVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRX5</accession>
    <name>A0A010ZRX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076844_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="23844" checksum="49994F32604D9C8B" modified="2014-06-11" version="1">MNARTGGRIGAVVGLVAVAALLTGCDQPLRNKSEANYDVTDTVRTLSVTGDAVTLDVVAGDGPVSVEEVVRYNGDKPRTSHRVTDGVLKLDSPGCRGTKACEVRYRVTVPAATALVTDVDAGKVDATGLSGRFDVRIDVGQVTADRLLSRTSDVRVNVGDVDLRYATTPDRVGVTTNTGAVSLRLPGAGPYAVRTHADVGDTDVTVPRSATSKHAVDVTVDVGQITAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRY8</accession>
    <name>A0A010ZRY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569768.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1018"/>
    <dbReference type="HOGENOM" id="CLU_1515437_0_0_11"/>
    <dbReference type="OrthoDB" id="1448007at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459167" evidence="1">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="17309" checksum="45F5991B5EA6A229" modified="2014-06-11" version="1">MSALVKRLAAAGSLIAAGAALVLVPSPAYADTVTVNYSCEIPLSGTQTGDVEVTITAPATATVGETVDVTVTTGPIPILPPIDLDAGSVTPSGEVTVSGAQTGAVAVTGTPNPEPYPANQPVQLTALTGQLTLTTAGEVQLSPGAVNATATTIFGTFTIPCVPTATPTPVAAVISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS58</accession>
    <name>A0A010ZS58_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848828.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1093"/>
    <dbReference type="HOGENOM" id="CLU_073546_1_0_11"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="196"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31454" checksum="1E33FCF9F462AAFA" modified="2014-06-11" version="1">MRAKFVLTEAATGLWRNVTMTVALILTTAISLALLGAGGLLYTQVNKTKDLLYAQVEVTIFLETAVTPEQKDALQQKLESDSAIKSVTYESKQEAYERFKELFAESPDLVENTKPESLPESFRIKLENPSQANAIDAKYKNEAGVDVVSTQQELVGRLFDAIDAVKNLSLVVSLVSGAAAILLIGNTIQVAAYSRRREVSIMKLVGASNWYVRLPFILEAAVAGLIGALLASAGLAIAKVIVIDDALKALGQNSVVPSIGWSEIAVTAPILALVAVLTAGVTGWTTLRFYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS70</accession>
    <name>A0A010ZS70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570098.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_12_0_11"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="506" mass="53033" checksum="FDD302DA88C57572" modified="2014-06-11" version="1">MSGSREDSALRPAGSGPLLGVDLGLTNTVALLRRPDGRSSPLLFDGEPVLPSGVLLDADGTVRVGRDAERAAASDPDHFEPAPRRHITEQKFRLGERDTTPTDLLAGVLTAVAKSAEATLGTVPPAALTYPVRWAAAEQQTLREAAGHAGFADVTLIPEPVAAVAAVGASMAVERRLVVVDVGARGFDVSVLAPSSGRLAVVAVGGDPTVGGRRIDAAIAAHLAAAAGRQRREIWRAIDRPRTLDQRRAQREFWADVRAAKEALDEAEFVPVSVPGTADIVPLTRADLERFARPVADRVARVTARVLREAQVTPEELDAIVLVGGSAPLPTLWVTLRDTLGIEPVQPDPPAFAMAGGALGRLAADLALPVGTRPAAGGAAMGVPRPPRVVAPPRLPVAGGAFTRVARAAARLVRRPVAEISAPPRRAALPAPRQPEDGLPGLAALPALRPIPEVPDQRRAPLHSAAHRDPSQPYERAALAWTRFGWFLVLLAIVAVLAVAGFVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSE8</accession>
    <name>A0A010ZSE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein, copper resistance protein CopC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_1213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1192"/>
    <dbReference type="HOGENOM" id="CLU_023176_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458072" evidence="10">
        <location>
            <begin position="39"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="11">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="12">
        <location>
            <begin position="351"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="644" mass="67123" checksum="3968143440DC06F0" modified="2014-06-11" version="1">MTTRTTGLGNRVRKVQRALVVALFALLAIGFGASPAQAHATLEGTDPPTGSIVDPAPTVVTMNFSERVTPVKGRIKVIAPDGANVVQGEPTTVNGGARVRIPLKSGLADGTYLVSYRVISADGHPVSGGYTFSSRVPSALGAKASEVNSGTASASVDNGVRGVQSVSRYVAYAGLVLLTGPLVIVLGLWPRRLATAGPRRVAWIGWGLLAAGTLGVLVMQAPYADGGTLADVSVSGIGEAIDETVGRALLIRLALLVAAIPVLIRVLRPAAKGGDAPGWAGPVDRVLVGVLGVALLITFPFAGHAGQSPAPIVSVPAITLHVGSMAVWLGGLVVLAFYLLPRAKYRELEVILPVWSRWAFWAVGALVFSGAIETFLEIGGFRGIDRLVNTTYGQLVLTKVIWLGAIMVVAANARAWINRRFGVPVAYAFAAEDAETPPKEATKSEKSEKSAATTKTAAKTAAKTAAKKTTTKAAAKKAKEPEPESADFSASGRASDEVRRLRSRVAIEVALGAVVLALATALVQVAPARSADDAAAAAAALPYSAQVDLGPNVLQIDLPARIGRNELHLTLFDKNGLPVKVEEWSGSAELAKANVSTDVVALPLTENHAVGQVELPIAGDWKFVFTARTSDIDQYSVEKTITIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTV2</accession>
    <name>A0A010ZTV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569932.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1696"/>
    <dbReference type="HOGENOM" id="CLU_456141_0_0_11"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="598" mass="62660" checksum="53D3B796E5B048BA" modified="2014-06-11" version="1">MSGTTLAVDYGTSNTVALLRWPDQRIRPLLFDGSPLLPSAVHLEPDGTVRAGPEAVRAARVRPECYEPTPKRRIDEGTLLLGEREISIAAAIAATLRVVWDEATRTAGAPPGSVVLTFPVSWGAVRRAVLVDAAVRAGLPAPALVPEPVAAAAYHVRAQGGRIPDGQSIVVYDLGAGTFDVSVVSSAFETLAYDGLDDLGGVDLDALVVAATGVSFDPGSRAFRQLWDDARAAKESLSRRSSAEVLIPSLDRDVRVTREGFEAAARPLLERSVDVTAAAIDASPGRVAGLFLVGGSTRVPLVATLLHRRLGIVPTVLDHPEIVVAEGALHTVPAEPAAVAEVKPPGVTIASRPWLIALRGLAVMLAGGSTVLFALFGLAATLFVLGERHQLLPDTGSLVLFGVVLVAGAGVFGFGSQVTARAFDRAQLGFEPDRLVVRSTARIGHALVRIGGRLLIGAAFAAAGLEVVLYDARNATAWAVLVGCVAGFVGSLVSAVAQFRHRPVRIDATGSSTADAELAWADLAVAEIRPVGWRRSRTLFVSLAPGVARPSALRPVRGSEALRVLDLGAYAMPVGRVEKAVGHYWRSVRDETAPTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUK2</accession>
    <name>A0A010ZUK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_1972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849995.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1936"/>
    <dbReference type="HOGENOM" id="CLU_025947_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458413" evidence="10">
        <location>
            <begin position="22"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="12">
        <location>
            <begin position="116"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="11">
        <location>
            <begin position="261"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="470" mass="49354" checksum="1AFD90DC253BF5E7" modified="2014-06-11" version="1">MSSRTVALIAFLVLGAAVVLAAGLLTPWRTTPAERTPAEKSPAEKAPGKTTPAGETSGKADPARKTTPAGKATEATDPAPPRPDAATDFTEAEISRGSAFRAALRPWSLARLALGLVIALVLGLTPLGARLIGAVARPLGGSWWSEALLGGVVLGLVATVITLPLAARSEVLLRRYGLSTQNWGGWLADQAKGWAISAVLTAVLTLMLFALVRATPNWWWTWAAAGAAAFVFAASFAFPVLIEPLFNKFTPMPDSPLRTSLVQLAERDHEPVKDVLVADASRRTTALNAYVSGYGASRRIVVYDTLLEQAPPEQVESVVAHELGHAVDGDVVTGTVLGALGAAAAVCGLAVLGGSTALLRRAGVESLTDPRSIALLLAIAALAGVFATPVQGLVSRKIEARADEHALALTRDPEAFVAMQRGLALQNRADLRPNRFFQVWFGTHPTTVERIAAARAFAARENLPIPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUT6</accession>
    <name>A0A010ZUT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar hook-length control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the length of the flagellar hook.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2032"/>
    <dbReference type="HOGENOM" id="CLU_428797_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001635">
        <property type="entry name" value="Flag_hook_Flik"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01007">
        <property type="entry name" value="FLGHOOKFLIK"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458279" evidence="5">
        <location>
            <begin position="18"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_hook" evidence="6">
        <location>
            <begin position="506"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="638" mass="61056" checksum="A4B7948EBEF6820C" modified="2014-06-11" version="1">MSISPLPASQSTMSLMAATNTTPARPAGEMGSDNGPRQGQDDDERFVSALQAASGSKGADDTTISEQDSSEGPKTKQKPSKAPEEDSGRRAVLNQAWHTTMTGMPPSDTAGALALPAALLAHGQLALGSGATGDIGADAPPVAVIGIGVVTEGEGGIATGPVLNPATLGLNAKGSPTFTGLAGLRGLAGPDVPGVAPPDGGSPSTRAFGLPELTVVGAAEARPAVEAAITANADSAAAAASLAEVDLAAFTGALGEAGALGDGLGAAPAPGAGIPGAGAPGAGGPGAGGPSAGGPSAGGPGAGGPSAGGPGAAPPGAGATGEAAGLGQGIDLSGLAGLEAGGGPPVVTKSGRQLSPAELAATQATAAQNAAAQVAAVQATAAQLDQFLAADPVLTAAPVPAPGGPIPAPIDLPGYVPGALGVGPGTTGDAGTGSGTEGGREEGFTDALAAADAPAAPDATAFTPLHTPDVSQPQQLDLTGANAPDQAPPPPPAAQVAEQIIPLRTQGDGVHRIAMELRPDDLGTISVVAEIRNGQVHLHFGGANEMTRETLRAALPELRQQLEDAGFSGAAFDFGDSPAGQQNRQFAATGQGPGGQPGRNGQPGDPGAETGRPAAPRPGGYPEPTPTGAGRHALDLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUX9</accession>
    <name>A0A010ZUX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850171.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_1_11"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="28660" checksum="09571E141955A538" modified="2014-06-11" version="1">MSEFLGYLVAGTALGCTIALLASGFVVVHRVTGVVNFAQGMFPVVAGLAAGSLLSAHWPHGIAELGGVALAGAVGLVVGIVAIGKPGTPPLASLVITFGLGFLGYAIEIIVWGDQPRGFDGLSGVVTIGEVRIQHQWLLVMLVAAGTFAALGAFFGRTYLGKGLTACAANPYAARLAGIDVRRMGLYAFGLAGVLGGIAGVLLTPLQSIAFDRDVALAVNGFAAAVLGGLDRPGTALAGGLLLGIGQTLFAGYVDGSFQTEVALGFMVLVMVVRAVRQPQAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVF3</accession>
    <name>A0A010ZVF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852611.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3842"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_11"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="25228" checksum="57925AAFFD6F4B89" modified="2014-06-11" version="1">MDTALARCGLFQNVEPRAAEALASNLKYLDLFKRDVIFAEGDPGDSLYVVLEGKVKLNRSAPDGRESLLAVLGPSDLLGELAVFDPGPRTASAVVVADARVAQMRRDQLRPWIAEHPEIGPQLLRVLARRLRRTGDQQADLIFTDVPGRLAKALLDLAQRFGLPERSGPDDAVRLNHELTQDELAQLVGSSRETVNKALSHFATRGWIRLDGRSIVLLNRDRLVQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVJ6</accession>
    <name>A0A010ZVJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase B/acetone carboxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850471.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2300"/>
    <dbReference type="HOGENOM" id="CLU_020413_1_0_11"/>
    <dbReference type="OrthoDB" id="1018930at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="2">
        <location>
            <begin position="43"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="785" mass="83530" checksum="9F576FC6A7988F65" modified="2014-06-11" version="1">MTMPIPGSERFASRPVDPDALAAELPDSLPVHSVTQDQIDGLDPLTYEVIRHRLWSVTEEMGEALQRMSGSPIVTDANDFDFAICDEVGQEVQVGLYNTMLVGAVDLAIYWTLRNRATNPGIREGDMFLCNDPWVGGGLHQNDVIVYQPVFHDGKLFAWTSAICHEPDLGGVGLGSFSPAAQDVFSEALPTPPVKVVRDFALQDDVADLWIRRSRVPMLVSLDLRAKIGANTVGRKRLHEVIDQYGADTVKAVMKRMMSDAESRLRDKLRSLPDGTWKATGYQDQSHEGDRGVHKITVAMVKQDDRLTFDFTGTDPQAGVINCTYAGMRGGVMLALLPMLAQDIPWSAGGLMRCFDLISEEGTINNATFPAAVGRGPIGPAWLTGTLVAECLSQLLDCSPDLGKSVQAACCGTWDTAVVAGLDQRGEAPVPFLNIMMEPMAGGYGARPELDGMDTGGLFCIPMGRIPDVEMTEFLYPLLTLWRREEADSGGPGRQRGGVSASLAVALHGSQVPAGVVFASAGKAVAQNNGLAGGYPGNTGLEVLVRGADVHRALAEGRIPQSVEDFGGEAEIAPCYAQSYLAPGEVLYMNWQGGGGYGDPLRRDPEAVAADVREFKVTPGAAADVYGVVLAADGSADVEATAERRRELAEARGSRSGAAPAPDPAATSAPDPASDQASDPAGTVDLATARRIDDNLVMSGSLVGCAHCGQKLADTTTDTQLALLRYDGPVTEAGPQIVSDPRDYIDDEVVFRQLSCPGCYTAVYSGVVPKVHVDHSTDIARFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVZ7</accession>
    <name>A0A010ZVZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852840.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4018"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_11"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="28"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="481" mass="49376" checksum="1C02859A955FA9BD" modified="2014-06-11" version="1">MSDLIDVLDPSRGLLIGAERRRGGAGLFDVRDPASGRVVASVADADSADATAAVDAAAAASEGWAALAPRARSEILARAHALMLRDADDLATLIALENGKSRSDARGEVVYAAEFFRWFAEEAVRTGGDYGSSPAGGTRTIVTHRPVGVAALVTPWNFPAAMATRKIAPALAAGCTVVLKPAAETPLTAIAVVRLLVEAGVPDGVVNLVPTTDAGGVVGTWLADPRIRKISFTGSTRVGRLLLQQAADRVVNASMELGGNAPFVVTADADLDAAVDGAMIAKFRGGGQACTAANRFFVHAGVAEEFAARFGARVEALTVGPSDTGAEIGPLISAAAVARVTALVDDAVAAGARVAFSAPAPEQGWFVAPTVLTGVPADAAILDEEIFGPVAPIVTWTDEADLVRRVNATEAGLAAYVYAGDLGRALRLAERIDAGMVGVNRGLVSDPAAPFGGTKQSGLGREGARAGIEEFRETQYFSVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWF5</accession>
    <name>A0A010ZWF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">CryarDRAFT_2668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850915.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2630"/>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_11"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="29591" checksum="51DF6EA0D69E57FC" modified="2014-06-11" version="1">MAIFLTEKSRVLVQGMTGAEGMKHTRRMLTAGTTVVGGVNPRKAGTTADFDGMRLPVFAGVAEAMGETGADTTVIFVPPAFTLAAGLEAISAGIGLAVVITEGVPVHDTAALWAHAVAAGNTTRIIGPNCPGLISPGKSNAGIIPADITGPGRVGLVSKSGTLTYQLMYELHDLGFSTCVGIGGDPIVGTTHVDCLQAFQDDPETDAIVMIGEIGGDAEERAADYVAAHVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAEAKQKALEAAGVRVGRTPTETAKLLRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWJ0</accession>
    <name>A0A010ZWJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative permease, DMT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2666"/>
    <dbReference type="HOGENOM" id="CLU_033863_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="138"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="38954" checksum="87D0E9DB84F9E721" modified="2014-06-11" version="1">MLIATAAAPATWGTTYLVTTEFLPAGRPLLAGVLRALPAGLLLLAIVRVLPRGSWWWRSAVLGTLNIGAFFALLFLAAYRLPGGVAAIAGAIQPLLVAALAVPALGERLRPRMVAAGAAGVAGVALVVLTAQARLDALGITAALGGAASMALGIVLTKRWSSPTRTARGAGTPPPPLVSTAWQLVAGGLVLAPVAFAVEGAPPALDAAAVGGYAYLAVVGTALAYALWFRGLAALPAGATSFLSLLSPVVAVLAGWLVLGQALTLTQALGVATVLAAVLTAARAAILPTPQPTPAPRPTTPTSGPSPTTTRGGTNTLGATTTPSPTTTVGPTTPLSPTAPLGATTTPSPTTTVGPTTPLSPTTPLGATTVGQSASAPRPASTPRPAAVPPQPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWK3</accession>
    <name>A0A010ZWK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850982.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2681"/>
    <dbReference type="HOGENOM" id="CLU_138549_1_1_11"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="13056" checksum="ADE2C3F381D38CA3" modified="2014-06-11" version="1">MATWDDVRRIALALPESSEGTSYGAPAWKVRGKTFVWDRPVRKGDPEPILGVRVADEGVKAALIADDPDVCFTIPHFDGYAAVLVRLDRIPLDELTELITEAWLLRAPKRLAAEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX89</accession>
    <name>A0A010ZX89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2923"/>
    <dbReference type="HOGENOM" id="CLU_027853_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="35534" checksum="2AABA09380FF627C" modified="2014-06-11" version="1">MPINKLGFLTIGLFDGADPRPGHESTLEIIQLGEQLGFDSAWVRHRHLQYGISSPVAVLAAASQRTSRIHLGTAVIPLGWENPLRLAEDLATVDLLSGGRLEPGVSVGPPMHYDRVKPALYPDTEEDFSYERVARLLRFVRGETVTDAGVEGFEVFSNRIEPHSPGLGGRMWYGGASLRSARWAGENGMNFLTSSVVKAEESEDFAQIQLSHIRTFRAANPGGRVSQGLVVIPTDSASAEQRAKYEAYVEARTPRTTTPQGPARMLFARDLVGPSSQIAEQLAAHAAFPEVSEVAFALPFSFDHEDYVQILTDIAGTLGPALGWTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXS4</accession>
    <name>A0A010ZXS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase family protein with metal-binding cysteine cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851534.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3113"/>
    <dbReference type="HOGENOM" id="CLU_001338_1_0_11"/>
    <dbReference type="OrthoDB" id="9107at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="2256" mass="246638" checksum="6C01D97DA66805B6" modified="2014-06-11" version="1">MRPTLEANGLTANLLQYLSTTYALSDEGARRALEAFLGDTDAGMFRGPFLRIRTPFQPAPDNWRDGLDWPDRGFLPPGFTPYAHQAAAFHRLSSRHHPPLPTLVTTGTGSGKTEAFLLPILDHCRRERALGRAGVKAVLLYPMNALASDQADRLNHYLQQDAFSQVTAGLFIGDTPDTPYPRVMTRRSEIRNNPPDLLVTNFKMLDLLLHRADDAPLWADADLRYVVVDEFHAYDGAQGTDVAMLLRRLAARVGAATAEMPLGGICPVATSATLASPTEADTPGDAPDLLAVAGQIFGTRFTADAVISENRRSVEEFIPQHSLAAELPLPDPETLAALPDPGRNDEAMARLSEVVTGQPELTPEQLGAVLRTHVLTRALLTALADGVRDPAQILDVLWRHNAYSWGRAVTERPQQAALALARFVALLSVARDPDADPAHPRPLVHVEVHQWARSVTRLLRGILPWPEAEFRWDAADPAGATAVDGDRAAPVTTATGGQRANVFLPAVYCRECGRSGWAAFSPESDDAALRLDPVLIRRASTSRDKMRVRALIAATDAEAREGAGSGPMAVSNRAWGGTGRPAAAGLGGVLMVLDGAGGRLRPPQPSTDYHPETGEPTLTARDSAFVLVILGQTANTAATGDWCPACGERNAIRYLGTRTAALAAAALTQLFTGGELDDKQNERKTLMFSDSVQDAAHRAGFVANRSYVFSLRALLVAHLSESRDTALNDLIADVVAATTDLQTLAAVVPPDLHDRPGVDALLAGENGGTAGVWQTIGERLAFAALMEFGFRSRQGRTLELTRTAAAQVSIPNKDAAIALVRQAYLAGTELPADAPEDARYLGFLRIFLERMRWRGAVRHRWLTRYALDAGVSRYFVWGRRPAGMPAFPAFVAAPVFLLDRPRPRSEFDFATGRLSWHERWAQRSFGLTRDAAAKFWERLLPALASDGLLATRVTRDGQTRLYGLQPGAILVRGLTDDEVNVAAVRCPVCAWEQTVHPALLDQWRGQPCPSYRCARGRLEAANRPAANGSDPHRRDRDYRDDYYRRLYRGAGTYQIVTAEHTGMLTRPQRERVEKAFKAGGRFTDPNVLSCTPTLELGIDIGDLSAIVLASLPPSPAHYAQRVGRAGRRTGNAYVLTVLGHRQRDLYFLDRPVDMIAGRIIPPGCYLSAVEILRRQYLAHLLDLAAAGRLPAADGGTEPLRPLPRTAPALFGDSGYLVDLVATALAHAEELLGGFLALFPGDTIEPRAVDELRAFATAGLRSAVDRAVREWRERLAILAERLSAITATSAALNPDDPEQAQQRAELDGERRGIGALLARAGEKDAPGALVELGLLPNYALVDTRTVLEATLYAERRAESDETERSSAEVRYRTELREYDRPRRLALTELAPGNTFYVNGYRHEVTGLEIGTRDRPGWQVWRCCPECGYVRTTEAESDRTPCPRCRSGRIADDGSCLHRVVEPSRVTARDRREDARIRDDRDDRDPRFYETVTAVDIPQDTVELSWRHERRVFGIDFTRDATIRTLNLGPARFDVPARDLFAGQLTRVNPFTVCTGCGAAGADGAPVFDQDSDALLTSGPDDPRLRHHRPWCPLRQGRRDDTVQLPVLLAHQLKTEALRILLPAATVLVEERVHSFRAALRLGVDRHFGGDPDHLDTAIATMPDQNSGERRSYLVLYDTLPGGTGYLHRLTDPVAFKATLAAARAVLAACPCAAEGRRACHRCLHRYTPDNLQQHASRRTALELIDGLLTGPDGSDGWDISDVGGTDDIGLDQQVESDLEARFLALLRTWSTVTTDTVLEENSATSGHLRFTGGADVVHWRLTAQQPLDNTRPDFSFHRVDGPPCAIQVYLDGRRFHASTDNNRLARDAVRRTRLRSTGNLVFQLTWDDLDLFEERADRAQPVWPPYLTGAQDAAKAAYAAYEGDRSDFADTVLTNPVETLLAFLRDPDLTRWTRRARALVAGAAAMPGTVHVGTAGGSQEVSGLLRQALWECIPPSDRPDDRPTTDVAQVGGSVHLFRATDTAELPLVLVVDERSPEAWTALAVVNDLNADLDSITAKHTWRAWLYWSNLIQFLSLQGRADGVQLTASQTLEYPVEQLAIAGGVGELSSMKGSALVPYVPAPAEPVNDVPAGPTSGSARDPGWDVEILPYLDEQDSALARLARTLAERGKRVPVFGYELGQSGWPADFAWSDSGVRIAVVTAPHDADDDEARRRDAAYAEAGWTVRTAADWNLHLESLLAVLPDAAEPTEAVEETHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY42</accession>
    <name>A0A010ZY42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851727.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3231"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="220"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="371" mass="38112" checksum="4550913D6E47FE9B" modified="2014-06-11" version="1">MPDWLADARAVLDAGVGDSAAEWDLAGLLPEDLLRALGKRGVLCAEVPAAYGGLAATSVDNGALTAHAGALCSSLRSVMTSQGMAAWTISRLGDAGQRRRYLSRLVDGDLAAVAFSEADAGSDLSAIATTITSDGDGVVVDGQKVWTTAARYADLIVVVGRHGDGGAAVVVPTDAPGVTVTPVAHPSGCRAAGHADVRLDGVRLPADAVLGGGQQLAMLVTTALAYGRMSVAWGCVGILRACLTEASAHAARRHQFGKPLAEHQLVAGHLADLLAAERAATAVCEHASRCWDDRSPELVMATVVAKYVSSTSAARCAADAVQVLGSVAARDGHVVARAYRDAKLMELIEGTNEICRLLLAQHAVSGTTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYF5</accession>
    <name>A0A010ZYF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851896.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3346"/>
    <dbReference type="HOGENOM" id="CLU_027853_8_5_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="39986" checksum="B3DA4325B5274D77" modified="2014-06-11" version="1">MRFLAITLIVHAPHPVSGVQKSTNDRFREVVQNALLAEELGFDGFGVGERHERPFISSSPPVVLSHLASLTREIRLFTAVTTLSLLDPVRAAEDYATLDHLSGGRLELIIGKGNGAAQRELFHVTPEDQWERNAESYELFRDIWRDGRVTATPKFRPALQDAEVWPRPLQQPIRVWHGSATSKESVDVAARYGDPLFSANVTNPIEPYAELVRYYRERWEHHGHDPASAVVGAGTAGYYAAPNSQDAIEAYRPVFEGQRAFQKRLGLEPVFATLEDFVERSSALIGSPQQIVDKVHRYHDAFGHTVMHLHADAGGLTDVQHRDSLELFQSDIAPVLRKEIPDPPWGWGSPTPDEKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYP4</accession>
    <name>A0A010ZYP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3444"/>
    <dbReference type="HOGENOM" id="CLU_086503_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16553" checksum="60C609F3054E4A63" modified="2014-06-11" version="1">MIIAFDEYQIDDDASRIDRDAAWAFLSTEAYWNADRVRAEFDTQVAVAWRVVGAYESRTGRMVGFARAISDGCRFAYLADVFVLPEARGRGLGVAVVTAMIDGGPGAAFRWSLHTADAHGLYERLGFSKPDHMYLERPRGYGVDGAANAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZD4</accession>
    <name>A0A010ZZD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3741"/>
    <dbReference type="HOGENOM" id="CLU_100911_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="24611" checksum="2053468F997E9B20" modified="2014-06-11" version="1">MSHVFELRQYTLHPGRRDDLIELFDREFVETQEDVGIAVVGQFRDLDRPDHFVWVRGFAGMPEREAALSAFYGGPVWAAHKDAANATMIDSDDVLLLRPASPGTGFPPADAAAGPALTTATVYPFTEPVADATLEFFDREVEPLLARCGSHRSALLRTEPSANTYPALPVREGEQVIVRFARCADRHAHAAAAPVRDQIAALLAARSAGPPLELRLEPTTRSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A013</accession>
    <name>A0A011A013_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852760.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3982"/>
    <dbReference type="HOGENOM" id="CLU_380774_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="372"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="604"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="694" mass="72597" checksum="0CFE9442C7C49277" modified="2014-06-11" version="1">MSSKNNVLTTVADVEGAVGKPAAVIMLKQLGALDDGCRTILGASPVAAFGYRDAEGASRTTFVGGRPGFARVHTPTRISFGFSEPGAPHGPASLFFLLPGVGELLRVNGSVVARTGGRVVVEVTEAYVHCAQAVLRSRLWQPPAPPVDADAVPGDGAPGDGPLARPGVAGFLAAAPFLALSTWDADGGSDTSPRGDRGAVARIRDARTLVIPDRKGNRRADTLHNLLRDDRLSLAALVPGRDAVLHVRGRALITDDPALLATMALRGMPPHLALVVDVEDARLVGSGVLTRARLWSPGTHLDRRTAPDLAAIGSRHLAAGTGGAPSALLRAVAAMPGLGRVLRGVMNRAYRSGLRKEGYDDVSFAVGGEAANPLRSVRVTGIRRETPSAVTLVLEDGAPFDFRPGQFFTLVADVDGRPLRRAYSASSAPGTSRLEVTVKRVEGGRFSAFVHRDLRVGDRLELRGPSGSFHAEPGELVLVAAGSGVTPMMSMIRATLGTGRISLLYSSRTADEVIFAAELDRLAARHPDHLSVTHVLTARDGRLDAAGVRRWISAVAPSEDAGYYVCGPEPLMDAVVAGLGVPAGRVRRERFRSGADPTVATGPQELVVENDGRPVGSVVVAPGRTLLEAGLDAGFAMPHSCTVGNCGDCLVRLVDGDVAQSEPNCLTPQQRADGYVLACVSCPLSTVRLDIAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A057</accession>
    <name>A0A011A057_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852869.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="183" mass="20322" checksum="C42B046B86CB5338" modified="2014-06-11" version="1">MNTYLHTERLILRRFTADDADALIELDSDPEVMRYLTGGAPTAPDEIRERDLPGILAGYERWGGDFGVFAAETKDRGVFVGWFLLRPEPGGPADEAELGYRLRRAEWGKGYATEGSRALLDKAFTELGLRTVWAETMTVNRSSRNVLEKLGMTVTGTLDTPPDMRSIEGAEHGGVRYGITPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAG7</accession>
    <name>A0A011AAG7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="5" type="ORF">CryarDRAFT_0025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859748.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149126_1_0_11"/>
    <dbReference type="OrthoDB" id="2085550at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="89" mass="9752" checksum="2640CEED70E1004C" modified="2014-06-11" version="1">MPKSRVRKKKVYTAPSDVRPSAATTAKRAKPSPRWVPGVAIALIVAGIAWLVTYYMTQGEYPVAELSAWNLAIGFGMLVASLGVFTQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABJ0</accession>
    <name>A0A011ABJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725059_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="38649" checksum="0D578CDA6A20047D" modified="2014-06-11" version="1">MARSATTSRHGRRAAEPEHQHSVFEERSVLDALWSAVVAAPTSVMPPASPDAVDTTETIEGPEAPETAEVPEGPEAPEARETAETPEAAAPHAAPGAPETTPHEAGAHEAPEPEMVDEPVVEESAPPAPGKPAPEPFVPILGRPIIPPAPKPTEPGSADEPTTEHTPRHPSEPPPRTTGPFDLSYAAAPTTNRTIWAGPRHAAPLDWGSAGAMLTIETPAAVSDAGLLLMRLVVGLTMAAHGAQKAFGMFGGAGFDATADGFSALGYTPGAMFALAAIIGELFGGLFLAAGLLTPLAAGGIIGVTVNAMVAVNLGNGFFASHDGIELPLVLSGAALGLLLAGPGRYSVDSRIPFFNGAAVQCVAAGVALLAMLTSLGAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACP3</accession>
    <name>A0A011ACP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848587.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.836"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_11"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="35587" checksum="C5A518C926FE8E79" modified="2014-06-11" version="1">MATMRQVAERAGVSAKTVSRVVNNDRYVSEDVRRRVEQAIEDLRYTPNLLARTFRFGRDPAIGVAVPDISDPFFAAVTHTVEQVARGRGVATFVTSLGTDGSLERAAVEALLGRQIAGLISTPVSADQSYLEPWKSRTSLVFIDRPPRKLTADTVVEDDVGGARTATAHLIGHGHRRIAYIGDEVQIATTRRRLEGYRAALADAGLDTDESLIRFAGAGGNAAGDEAAGLLDADDPPTAIFSSNPNCSIAIVPALQRLDRTDVALVSFGDFPLASSLRPALTVVDQDPEALGRFAATRLFDRIDQPDRRLRRLTVLPVRLVERESCGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADD9</accession>
    <name>A0A011ADD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1112"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="23251" checksum="5A62164E9E456EE5" modified="2014-06-11" version="1">MSADLRRVPYGPGMSLRDRKRARTRQALVEAAADLFERHGYERTTIADIAAAAEIGTRTFFSYFPTKEDLLFPETEARLRAAKEAIDGRKPADGPVEVLLTALRIVGEDSDDLSSRYAALRLFLVRTVPAVRGRGLQIQSEVTREIARSLATAFPGELDEVTAAAMVGAFTGAVTAALQVLLEDLDDLPEPAVVQAAVERATAVALGTWTSPDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADH6</accession>
    <name>A0A011ADH6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569799.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087287_3_0_11"/>
    <dbReference type="OrthoDB" id="1738659at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="23241" checksum="B1C92EB720357AC5" modified="2014-06-11" version="1">MTYGFTRSDSALTLRLSAEEAQAVGLVVAQVAGLIQAGDRRGVMSLDLGPGSLGRASEAPREPFDVFDDFDKVEPDPEDLEIELVEDGVAGPSLDPVLARLFPDGYRDDPESAAELRSLTESSLREEKIGNAGVILDDLPFEGGEVRLDAERAEAWLLALNDARLMLGTALEIEGDTDPLAELDAAAGSDPTGARVLGLSLYQFLTGLQASLVDALDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADI8</accession>
    <name>A0A011ADI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ORF">CryarDRAFT_1181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1161"/>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_11"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="26759" checksum="4F5E5ADAA5A4E7E2" modified="2014-06-11" version="1">MVKAAATDALVIAGRPLASRLVMGTGGGSVNLAVLGEALRASGTVLTTVAMRRVDAISGMGVLPLLKEYGIEPLPNTAGCRTASEAVLTAELAREALETDWIKLEVVADDRTLLPDPVELLVAAEQLVAAGFTVLPYTNDDPVLARRLAEVGCAAVMPLGSPIGSALGIRNPHNIALIVEEATVPVILDAGIGTASDAVQAMELGCDGVLLATAVTGARDPVAMATAMRLAVESGRLAYRAGRVPRRWYAQASTPPVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADL3</accession>
    <name>A0A011ADL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter, permease protein CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848928.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1186"/>
    <dbReference type="HOGENOM" id="CLU_056469_1_2_11"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="26870" checksum="9A3BA4F1C38FEA87" modified="2014-06-11" version="1">MGAGHAHPLHLAGASLVHRMPSEVKIVAALAFVVSVVATPREAVWAFGLYAVLLAAVAATARIPAGWLAARGLIETPFVVLALVLPFLEGGPHVHLAGLSLSEPGLWAGWNIVAKGTLGVFASLLLAATTNGRDLLIGLQQLRTPAPIVQIATFMLRYADVIVGNAKAMRIARLSRCHDPRFLWQVRAFATSIGSLFLRSYERGERVYVAMLSRGYTGALPTATSARPPARQWATALTIPAAAAAVSVTAWLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADS9</accession>
    <name>A0A011ADS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1253"/>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_11"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="518" mass="57300" checksum="DB579B559AEEEFB7" modified="2014-06-11" version="1">MSGVETTPTTVDGAEKILSPEALDFLADLHRTFGARRKELLARRKERRTEIARTGKLDFLAETATVRDDSNWKVASAPKDLLDRRVEITGPTDPKMTINALNSGAKVWLADLEDANTPHWDNVVGGQVSLYRATRRELSFESNGKQYALGEDLAVVVTRPRGWHLDEEHITVDGEPVAGAIVDFGLYFFHNAKELLARGSGPYFYLPKTESHLEARLWNEIFTRSEASLGLGNCIRATVLIETITAAFEMEEILFELREHASGLNAGRWDYLFSVIKNFRDAGPEFVLPDRAKVTMTAPFMRAYTELLVATCHKRGAFAMGGMAAFIPSRRDPDVNEKALAQVKADKDREAGDGFDGSWVAHPDLVPVCLDAFDAVLKDKPNQVDRLRPDVHVAASDLLDVANTPGEVTEDGVRSNVSVALQYLKAWLGGLGAVAINNLMEDAATAEISRSQVWQWVHQGTILDTGDTVTESLVRRILDEEVAKLGEGYDQARTLFEQVALADDFVDFLTLPAYALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADT6</accession>
    <name>A0A011ADT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849015.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1257"/>
    <dbReference type="HOGENOM" id="CLU_047208_0_0_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="464" mass="48047" checksum="AD309E129BD74F1B" modified="2014-06-11" version="1">MRDRYQQLVTTVPGRFLARRVGLPEPPHLRRHTPGDPLIPGTVVLGSAPADAAPGGTAAKDPGGTAGRLAKVVAPMLAAAGVAVRELGPRTEERPGERTPHALIFDATGITRSEQLLALHAFFAPQVRALAPSGRIIVLGTPPEHCVDAREATAQRALEGFTRSTGKEVKRGVTSQLVYVTPGAEDGVESTLRFLLSGRSAYVSGQVIRVGSAEVPPPDDWERPLAGKVAVVTGAARGIGEAIVGVLARDGAHVVCVDVPSAASALAEVAAANGGEAYPLDITERDAPAALAGHLRDGVDVFVHNAGVTRDRTLANMDAARWEIVLNVNLTSEERINDVLLGENVLRPGGRIVATSSMAGIAGNPGQTNYATSKAGVIGMVRSLAPTLASRGSTINAVAPGFVETRMTAAIPLVIREAGRRMNSMTQGGRPIDVAETVAWFASPGSAGINGEVIRVCGQSLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEM8</accession>
    <name>A0A011AEM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849403.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1479723_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="20528" checksum="C9878DC75253EF90" modified="2014-06-11" version="1">MTNKTEPGWSDQVVAHVRRFWDGRLRAIDPARIHPDLSAVTRRYLSDVGLPDFAPRWGFECIADRTDQILTRDGRDYVVVGGIRGTSLLYGIDVRTDQVFCVNSQDPMDEPELMNTTVALWVLSAGAVDREIISQIGVVEPDSAEAGAVVERVRQFLTAMDPVAMRYERGRTWHGYLNSFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEW1</accession>
    <name>A0A011AEW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849516.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1626"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_3_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="40677" checksum="7D60388FCE74A1CA" modified="2014-06-11" version="1">MSWYTPERQLLRASTRRFTEREIVPQLPAWEEAGELPRSLHRAAAKAGLLGVGFPESVGGSGGDPIDVQIIVEEMILSGGSSGLIAGLFTHGIGLPHLVAAGDPDQIDRFVRPVLAGENIAALAVTEPEGGSDVAALRTRAVRDGDHYVVTGSKLFITSGVRADAVTTAVRTGGPGAGGISLLVIERGTPGFTVSSPLKKMGWWCSDTAELRFDGARVPAANLVGAENSGFGQLMTQFAAERLGLAVQAYATAARCLALTLDWVKIRETFDRPLASRQVVRHKLAEMARQVDVSRTYTRAVIDDWLADPTRGDLVSRVAMAKNTAVEACDEAVDTAVQLHGGLGYLRESEVERHYRDSRILGIGGGTTEIMTELIARLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFN5</accession>
    <name>A0A011AFN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1884"/>
    <dbReference type="HOGENOM" id="CLU_017262_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="585" mass="62865" checksum="44888B8B7DB6B54B" modified="2014-06-11" version="1">MPDTVSSPSNTASSPSKGSTTGGVSVRLPVGSEPPRSGRRWDGLLTRLLPESHRMPVTVTFLTSLLLAVGFLSLPLAGTDLSAQVARGHFFDEHGWVPIDFRWYGGVYPFGYSAFTGPANAVFGSRGVGAISVVVSAVAFAWLLAQVGARRPLTAGVLGAITGVFNLVSGRTTFAMGIALGMLALCVVAASAHRYRPPLDDSAHWMRALLQPRASWWEMVLAATLAALSTAASPVAGLFVGLCGTALLLSGVVAEGLVLGLGAGVAMVVPTFIFHDGGVQPFSEESMKVCVAACLAVVLLVPRRGYQAVRIAAVLSAVGAALTYYTHNPVGSNVVRLSMLFAAPVVVAISTFDRRLLVGVVALLCWWQPPLIGGDLAYAGAREATKLYYQPLMDQLERRGPVGRVEVVPLRDHWESTYVADVVPIARGWERQVDVDRNPLFYDDTLAPDTYLSWLYENAVSYVAVPRGDTRLDPAGREEAALIEANLSYLRKEWENTDWSLYRVVGGPSVVAYPAQLESSGATGVRFSSPVATDLTVRVRWSPWLVLRGPEGCIEPDGTWVKVRLTRAGSYFLTGSFDQPWRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG64</accession>
    <name>A0A011AG64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850169.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2075"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="24282" checksum="3E679ADA5323C684" modified="2014-06-11" version="1">MLEVRELVVRYGTATALDGIDLDVAPGEMVALVGANGAGKSTLVNTLSGIVRPAAGRVRLDGRMAQVPEGRQLFATLSVEDNLRLGAWRNQRSRRDPARIYDLFPDLVRLRQQLAGSLSGGQQQMVAVGRALMADPDLLAVDELSLGLAPLVVRDLAAHLAELNRDRGLAVLLIEQETTLAFELCGRGYVLEAGRVVASGPSAELRASPAVAAAYLGGLAPAPTGPADGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGG1</accession>
    <name>A0A011AGG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850286.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091709_0_1_11"/>
    <dbReference type="OrthoDB" id="2060720at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="18802" checksum="0D998279D3106181" modified="2014-06-11" version="1">MSVPAPRRWAVLAAYAVPLCVLPSAIWRLSLTVTDGQFHWYPTFLSALSLTLALLTLGLVHDRGLRFPDWVPGKAGRAIPSRPVVATALIGGSILVALCVYLALNHALHVVDRGWVGIGRDEPVHAPPGWSVLRYYAPLVAWGPLVIAVALDYHRRTGRTKTAVDDAGGTASAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGU9</accession>
    <name>A0A011AGU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850448.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2289"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="31819" checksum="8137F6AB45A44481" modified="2014-06-11" version="1">MSVIEVEALNLSYGDFHAVRDVSFEVRSGELYALLGTNGAGKTSTLETIEGHRAPTSGTVRVFGHSPRDRRAVRPRMGVMLQESGFSPDLTVRESVGLIGALTHRTDDVGRVLDLVGLTGKAGTTVSQLSGGEKRRLDFATAVFGTPELIFLDEPTTGLDIQSRDGLWETVDRLREKGATIVLTTHYLEEAQQRADRIGLMHRGALRREGTVSELTRTLPSVIRFRLPPGVGVPPLRASRQSDGRYLIETHELSKELYLLLGWAHDAGVELHDLEAGPTRLDDVFRALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHB6</accession>
    <name>A0A011AHB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850714.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2486"/>
    <dbReference type="HOGENOM" id="CLU_133236_1_0_11"/>
    <dbReference type="OrthoDB" id="2021052at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="13092" checksum="FA22818319E994DB" modified="2014-06-11" version="1">MAVRALRGAIQVDENSRDAILEGTTELIKAVMHRNTITPDDLISVIFTATPDLDAEFPAYAARLLGFTDVPLLCTTEIGVPGAMPRVLRLLAHIETETPRSGLHHVYLHGAAALRRDLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHN5</accession>
    <name>A0A011AHN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850887.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2611"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27675" checksum="58D96C84E13BF3DA" modified="2014-06-11" version="1">MSGLLQDKVVVVSGVGPGLGRSIAVRSAAAGADVVLAARTEARLAEVAKEVTALGRRAVTFRTDIRKDDDVEALAEGALTAFGRVDALINNAFAIPPLEKLSDVDPDGIRRGFETNVLAALALTRRFLPALQDSAGAVVFINSAVLRHSRLTFGPYKMAKAALLALAQNLATEVGPQGVRVNSVAPGYIWADNLKWYFDYLAGERGVTSKEVYDETAADLDLRRLPEPDEIADAVVFLASSMASGITGQCLDVNCGEWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIG0</accession>
    <name>A0A011AIG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851206.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2853"/>
    <dbReference type="HOGENOM" id="CLU_056329_0_0_11"/>
    <dbReference type="OrthoDB" id="1564925at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="31620" checksum="7B0237218F3058A0" modified="2014-06-11" version="1">MTRSAFADSLTEVTEIRAREPGRVAALLAARRTRPTLPADGRLMLLACDHPARGALAVRGRPDAMADRGDMLARVRTALRRPGVDGLLATADVLDDLLLLGALEDKVVIASMNRGGLLGSAFEADDRMTAYDVRTVVEAGFNGAKMLLRVDLDDPASVATLETCARAITELSRAGLLAMVEPFLSRRVDGKLVNDLSPDAVTRAVHIAQGLGASSAYTWMKLPVVPDMDRVMAATTLPTLLLGGDPTARPDETYAEWAKALALPSVRGLVVGRALLYPPDDDVVTAVDTAVSLVRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AII8</accession>
    <name>A0A011AII8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851260.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2898"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27294" checksum="C85B5FC34D21732E" modified="2014-06-11" version="1">MDLRHQTALITGASAGIGAEFARRLAAGGANLVLVARRRDRLEELAATLRAEHGVQVEVVPFDLARPDAGRALRRLVTQPVHVVVNNAGFGNYGPFVAEDPERLAAMIQVNIAALTDVSHAFLPAMIEAGEGTLLNIASVAAYAPTPSMPVYGATKAYVLNFTEALAYQLRTTKIRVLVYSPGATESEFFDVVGTRDAGGGVWQTPAQVVTGALRALDGRAPSAVAGLPNRAMVSVARLLPRRWSLAIGGRLAYRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIQ2</accession>
    <name>A0A011AIQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851359.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1616268_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="16913" checksum="DD551B07B5026CBF" modified="2014-06-11" version="1">MKPLARAAYVVGVGAALLVAALFLPRSRTVDAITGTDASRPNTAEALLLLAAVLVAGVLAVVGLTRSRPWFVAAAGIPGFLTSLAWLWYVVDLRSGNRDLSSCAHEYFCTALLRVRPDVGAYLIVVAGLVITLGGAIAVVIARRPAPKPTGTKPTGAKPTGAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKE4</accession>
    <name>A0A011AKE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570520.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3587"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="359"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="496"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="767" mass="83349" checksum="2A171A50F0F39657" modified="2014-06-11" version="1">MLNWFRTGRVSAAGVLACGLLLVVQQVWFFAGWGGSEVSRLVTDAAYVPLAIVFTVLAARVARSKRQERRTRRAWRVITVAFICQLAAHCSWFAQEHLLHTTGYPSAADYFFLLFSPFMFAGLLMLPGRHRSRRQRQKLALDALIVGAGGFVVLWYLLLGPVFKTPGVTGWERAYTAALPIGDLLLVLAVSTALLRRHQADTPAPMRLLAAAITVTVVADVSYSWIQVHGGFTGGSWPDLLWLAGCFLLVLAADQQYRRPPRPGAWRGDRNAVSVLPYVAGAGAYLLLAERSSHLPLDPYGGMILGSAVLTLLVMARQLYALRENREMAVTDGLTGLANRTLITERLDQLARQPIRPGGHTAVMVVDLDGFKPINDTFGHEAGDAVLVATADALRAAVRGGDLAGRLGGDEFVVLMHGLPSRETAGAIADRLLEALRTPVIFGEHVLMVEASIGVLVRDEPDASGDTLLQQADAALYAAKRAGRGRFEYYSDLLDTRAREAELRRAVADDELVVYFQPAVELATGELRAVEALVRWNHPSRGLLGPDAFIELAEETGVVVPLGTWVLRTACREAAGWREAAGRPAATPDAADVRLSVNLSPKQVAQADLVRTVESILAETGFPPDRLTLEITESVILHPDPLTIGRLEALRDLGIELAVDDFGTGYSALSYLRNLPVTVLKIDRSFVTGIADDTEARAVCEAVVHLGEAFKMTVVAEGIETADQAAALIEMGCTIGQGFYFHRPLPPSEAGVLVRREYETRGQRHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALX8</accession>
    <name>A0A011ALX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853065.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061573_1_0_11"/>
    <dbReference type="OrthoDB" id="1865059at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="PTHR41700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="27645" checksum="387D747BBD3204CC" modified="2014-06-11" version="1">MPEPPCEAARAAADRAARRAGVRVRPLESMADAVGCEQLFREVWQTGAGQVPVPADVVRALIDAGSYVVGAFAADVLLGACAAVWGPPGSGRLHSHIAGVRASARGRDVGLALKLDQRAYALAAGVTEVTWTFDPLISRNAHFNLRKLGGVADTYLVDHYGPLVDGLNGDDPSDRLLVRWRLDDERTRRACDDGVVTAVEGARVPVPPDVEELRRRDPVEAGQWRRSIREALAGPLAAGGRLVDFDRVESAYRLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGC5</accession>
    <name>A0A010YGC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226838_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028908">
        <property type="entry name" value="Tox-PL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15644">
        <property type="entry name" value="Gln_amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Gln_amidase" evidence="3">
        <location>
            <begin position="908"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Gln_amidase" evidence="3">
        <location>
            <begin position="2204"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2020"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2394"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2020"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2494"/>
            <end position="2508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="2805" mass="294603" checksum="C5DC9736AAD6E7DB" modified="2014-06-11" version="1">MAVWKPDFGEYDYVWDFICGVTAGNPWPEGNEDDLWVLAEEWGAVAQALSDAMQDAGPVVNELMAAWGGDSGYAFLGLWEVLGQSYESGLGAVAEMASSLADMSDHAALELQYNKLTTLITVIITIISVFTALIGAFFTGGGSAVAIQPIMTGGRIAVQQSFRQLVRNIARKVVAKELRKELLKMVVTREGLRKLGKEAVEELVEEVLEEVVLVDGLSQAIQMANGRRTSWDGSKTAAAAIGATAGVPIGMGVAPAVRWAKNRAGRLVTDRLSDATIDRINRGIDRANSPSTHLGGLGKQFAGTPGQAVSVGLVNAVTSPTSSWIANGVVYGNWDYPTDSIMSSALAGASRANTISPAQLAAAYLTGGPTAFRETLLGSHPAALDPSVPTAHQPFPNALDTSTSTVLEVGQAEEPVQSPSAVLAEQTPATTASVNPNAASTPITAALSPDAEPAFAAKAVWTPEPDSIAGDSLAVPAAHSSPSVVLLADGGTDPAISIRGGSSPAPMVPAGSITSAATPMAIPGRESGGLTVNQPTVAPLQTRYDYTTSPNPSHISDLAEPTGSLTSPTPPNGNRLDGEEKSSRQPAHQPRTSPLAESAPENAVGIPAAQAAGGHLVHPTSSPGAKGPLPGSGNNPARMLRQSTGPTASGSQSYELAKQQGDPNGDLAQQAINAARRLADAVELTLASRIRNKTKRRRAMPKTAGALITRDGVIRTHTSIRSGLANSHPQLTPLLDGIKADLAARNLLPEWHGSCAEVALLSDFLYEFGQSYAGPPNEFLGAARLALAGAQIASVGIEMRHSHGAHKNPCASCAKLLIQLDVSAANAGPAPRRGLPPSIQPTLVDSAKGRLIGRDGGLARPDTADQAALEDAIPRDGDGNPVRFPDPYNRWLGLVNDGGPAATPFRANNCLDTALSLLGTWQGKPQVSAPRNAEYHADKTPSTAGETDGRQRAEETLGAEFEYQGASADTAFPALSAQLLSAGHGASAVLITSVAPSHGGGSHAWNAVNHNGTIHWIDAQIGAVSTRPLFEYAVDGVWSIVLDPSGQAVRAGDIPTVARGMASIEENGRSEGGSPAAPSVPLTTFAPDGRAAHLPDLEPGELLAAASQVRPADFKGRLVDAIDVGEVVTVRLRDGRSIRFEGAVAVGMQEVAATAVGRNRNVVTVNARVAPEHLARVWVHEIAAALQEKAPRGFFRRALDRIVGRRAGADSLLEARLSERRYLIRALSRGGSVELSRELDELDRYLADAGVRRLPPRPASALVPRAGNDRDLIAAAVSSRLAQVTYAGFELRVGAVDADSARVVVRLDVVNGDGRRVGVVHFSVNRDASGELYARLEQLRMNESGAGFVTTFNAALEEWLVESGVSRVEVRAVDAGAYAWARSGFYWSSPMTAESVFSRLGVERGRAAVQASVVRRWLAGELVPQDGLEAVAGEYPGVAPEAVLADLERQVSAADLILRRKGRAEFGSPGYPSPDEVALAGWSGVGRGWVGRRALVGAEWEGVRWLGASYRPDAPAGTEPSDVVAVSPRQMMKPTASASVGVRPGALADLGFADLDAETDELRRAIRQAEPLIRMVDPSEIKFTQRSIGRRARGNLTIDELAAAISQKWQGPPLHGVQWGDGSLVSIDNRRLAAARRADGLGLARVALVPIVPHSPDEALSDWPNDWSPERREGAALAADIRELADGSWVVGGHEGVLVHRAGKIPETFGQLALFRAALGRDLLPGALFGTHTPPVSVGRPPKPAKSAVSADARADLEQEVEAAAAAAPDIERDLIRAVANATGAPGTQKALWSPPVWKVRSATSLVFDYEDEKHFFNGPADFTAGRSDLVEFRVGLPDGAEYMDALSDFVDDLIQIGYVPTRAIDSWPSGNVHRRLVVTMRSPGGRLFDLHLPTHQFARVASAVAALDRVMEAPNEPPVRKVHALLRLLAAHKDLGNPEMVGRPPVLASIWSLDDETVESWIAEHPVLFDGYLDWLREQNLALRDVMVEFDLDDHDLWLRSSAADEELTSRDTRLLRALQEQRRRPGGFGRRSAGDGDARRAVVGPHPEGMGLQPGSGSSDPVQAQELRTDSLGEPGGSGGGYAGDHGWGAVAGRGDDSVALPVEGGAAGSGSVVEPPAEPAGGAPYFGPAGPFAREDPAFPLELTRGFGKQRLRRLENRAYQSAVDKVLSSVDGALVGADPRFHPYGTLINDGGPTQPGRDINCLDCSLAAISSFYGRPEVSLARWPDGTTMGELRGIERAMRWLDADTWLHHDHLPTMTEQFWALHDHVAELGPGSAALVVNVWQNADENGLLFDVDNRPLHGESHATVVVFPLGADGPVWWDPQEGTTSDTPPDDLVLDAVKLSYITVELDGRVNGDGTVGYEGSGAGLPGSRLPSRLAVEHAPVPARLGASVDSRDVGGSRAGATAGQSDIGARGEHRPNHIARVLSTASDHQPISGGGGGGPGPRRSADLSGAAPAGPTGERGALGSHPVERDGSALLPGSLPGLRSSGLGSDGSGQRSERPSIGDTIAPAMGVGSRFGRVPGSGPLPVNSPAGVPGGSGGVPPGSHGSGVAGRGDFSGPVRPERLSSDSGREGAVRGAAEAHGLGEPGELAAIASAHDVATRWTAPYLVAAVDRVLRRLNPLATDDVRFLFVTADDVVPWIVGRLAPDFARRRALWVQWPPTPGGWRHLRAQQPATLVTDNPAALPEAHQLLSPSAPGSRLVSRLHGPAADVSAMARAQRMAARAAVAAVVRMAMRAGPETGRTAVYAAANELDRRVAEFDARRAVPAGVGGHGSRDRDPWGDGARAEEQLLAEWLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGP9</accession>
    <name>A0A010YGP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-diaminobutyrate 4-transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848095.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.465"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="OrthoDB" id="386839at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="442" mass="46694" checksum="8CE9C070A61077BE" modified="2014-06-11" version="1">MTVLSRVDDTGIRNRQTARESSARTYARHFPIVPVRAEGMTVYGADGRTYLDCLSGAGTLALGHNHPVVVDALRRTIDAGRPLHTLDLATPEKDAFTTELFATLPARFAERAKVQFCGPAGTDAVEAALKLTQIATDRGGVAAFTGAYHGMTLAALTASGGTTGRRAPALDVTRLPYPYAYRCPLGLGGDLGAHAAASYVERLLDDPNSGVLTPAAMLLEVVQGEGGVIPAPDDWLRRMRAVTQAHRVPLIVDEVQTGVGRTGTMWAHERSGIVPDVVVASKAIGGGQPLAVVVYRDDLDVWAPGAHAGTFRGNTLAMAAGTATLRFVRENDLPRHAEKIGAQLRTGLEALAHPAIGDVRGRGLMLGVELVEPDAEPDHLGTRPAASALAGRVRTECLRRGLLVELGGRHDAVLRLLPPLVITEEQADSVLERLADALSACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGS1</accession>
    <name>A0A010YGS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848148.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051806_4_1_11"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="28464" checksum="8BDC42EEC89C4095" modified="2014-06-11" version="1">MRFVLQFVVVVAVAAVGGQVATGVQGNPWVSLVVGLIAAAVAALAYGWIVRRTEKREVTELARSKAAGGLARGTAIGLAMFAAVIVNIWFLGDFHVDGYGSVSGALGILGFMAAAATTEELIYRGLLFRWVEKVTGTWLALLLSGVIFGASHLFNPDATLWGATAIALEAGFMLGACYAATRSLWVTIGLHFGWNFGLGGIASATVSGNGDSKGLLDTTLSGSDLVTGGAFGPEGSLYTLTAGVVLTVVFLWLAARRGTIVPMRRKSSPRVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGU6</accession>
    <name>A0A010YGU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860214.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.522"/>
    <dbReference type="HOGENOM" id="CLU_015740_5_1_11"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="27"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="406"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="574" mass="62562" checksum="F51D7F4D771A8AC6" modified="2014-06-11" version="1">MSRFAASQLGPQQRADALARLRTETFDVVVIGGGVTGAGAALDAASRGLSVALVEARDFASGTSSRSSKLIHGGLRYLEQLNFSLVREALEERGRLLTTLAPHLVRPTPFLLPLNHHGWQRLYYGAGVALYDTLGSILGTARGVPRHRHLSRAGARRLFPSLRRDALVGAIRYYDGHVDDARFVLALARTAASYGAVTATSTRVVDLLRNAREVVGVRVRDLESDDEFEIRARTVVAATGVWSDDLSEMLHERPGLRVRASKGVHLVVPRSVISGDVGLILRTEKSVLFVIPWGGHWIIGTTDTDWDLDRAHPAASSVDIDYILEHVNAVLERPITHDDIEGVYAGLRPLLAGEDESSSKLSREHAVVEPMLGLMLVAGGKYTTYRVMAADVIDKAAHRLRDVPRSRTQDIPLIGADGFTAMWANRADLARRHGVTVGAVEHLLERYGSLTTELLASIDADPRLGQPVAGAPEYLAAEIAYAASHEGALHLEDVLTRRTRISIETAHRGLDSVEDVADVLAPALGWDAATRRREVEHYRARVLAERESQRMPDDLTADAARLGAPDVRKPSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGV7</accession>
    <name>A0A010YGV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848217.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.532"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_11"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="499" mass="53187" checksum="C759F4A3BB8885AE" modified="2014-06-11" version="1">MTAEVDRSSPGDDRLLHVLSDWSVGSGPLYQQLAAAIRRGIEEGALPAGSVLPAERRLAAVLAVSRATVVAAYDQLRGEGAVESRRGSGTRIARTARSGRIGDGRVPGGHSAQLFQRLIDGPGSVLSLASAAGMADVVVPTALEEVLHLDLAEAMLDPGYQPHGLARLREAITGYLTDLGLPSKPNEILVTTGAHQAIDLVAQLYLRPGSRVAVEAPGWPACYDVFRAAGATLVPVPIDQDGVRPEALAKVLAESPIDLVYLMPTFHNPTGALLSAARRRRIVELAAQHDVVVVADDTLSGVSLGHDVPPPLPSFAAAAGDRPVTLIQMGSLSKSVWGGLRVGWARASADVISRLARRKALADLGSPIIDQLVAARIVPGLSSLVERRVPERQEQLATIEALLAEHLPQWRWRTPLGGPSLWVELPGVDAAVFSQVALRHGVEAIPGRSMDISGGHDSFLRLPYCFPSEFLTEVVRRFAAAWAELERHGPWEPNLRPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH24</accession>
    <name>A0A010YH24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848316.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.603"/>
    <dbReference type="HOGENOM" id="CLU_1188353_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457869" evidence="2">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="24238" checksum="1DB0055078E4FA87" modified="2014-06-11" version="1">MVLFVTMVVLAVAVATTVTVGQKRTLTALAVTGGALWTAAAAGLALMSGVPPLLLALVGASLAYAVHHLTRRALATRDDGLPNALLLFSRRRATRIPAPIETTPTDITLTLNTIRVLDAERSRREPLHWSVVAATGIAATALEGYWAYQHLIAGGGVFSDLAALAGFAVLATLTVAGTGVAGLAVHMRTTPRPDSAPQSMPAPSDMETIAFTPITVGTTGRFGRRRPRATAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHH3</accession>
    <name>A0A010YHH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848492.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_4_1_11"/>
    <dbReference type="OrthoDB" id="1797448at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="25672" checksum="6C4B73C4EAA2F684" modified="2014-06-11" version="1">MSARARLRAALSAGRAVRGTFVKLAGEETVDVARAAGVDFVVVDLEHSQLSEEQARRAVSRAAAIGLPALVRIPTVDSGLINRLLEAGAVGLQLSTLRSAAETRALIGATRYAPAGTRSISLAHPGANYSGVPLADYLATEHETPPLLVGQIETATTDDPLPDVVEGLDVAFLGVTDLAVSVGLDDEDAIAARVAEIRATAAAAGVIAGSWAVSPDAAGDAAAAGDRYLVVGSDLQFLAASMRKHFAKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIK2</accession>
    <name>A0A010YIK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848869.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1126"/>
    <dbReference type="HOGENOM" id="CLU_064194_2_0_11"/>
    <dbReference type="OrthoDB" id="729805at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="155"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="25606" checksum="BDA4B0F327F1C235" modified="2014-06-11" version="1">MHQQVDVRPSASRNRAGSAWLESKRSFSFGAHYDPGNTHHGVLVVHNEDVVQPGTGFDTHPHRDMEIVTWVLEGSLVHEDSAGHAGVIYPGLAQRMSAGSGIRHSEKNDSARPVRFVQAWVLPDTPGIEPGYEQRDIGDELQHGRLVPVASGRPGHSAAIRIAQRDAALHVARLTPGESVLLPDAPFVHLFVARGGVELESTGSLTSGDAARVTGVGGQRVTASGATEILVWEMHATPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJF7</accession>
    <name>A0A010YJF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">CryarDRAFT_1438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569866.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1412"/>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20686" checksum="D042C33C2CDCE8C6" modified="2014-06-11" version="1">MGFDDSVFNRLLKERIIFLGQQFDDEMANRICAQLLLLSAEDPVRDIALYVNSPGGSVSSGMAIYDTMQFIPNDVATYGLGLAASMGQFILCAGARGKRYALPHTRVMMHQPSGGIGGSASDIAIQAEQMLYTKKLMQERIAFHTGQSVEQIEADSDRDRWFTADEAKEYGLIDAVLPTTSDVAATTGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJP8</accession>
    <name>A0A010YJP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849360.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1513"/>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_11"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="295"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="421"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="533"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="784"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="898" mass="98539" checksum="4180EB53EC7C8D9F" modified="2014-06-11" version="1">MTDQQKYVYDFSEGNKDLKDLLGGKGANLAEMTNLGLPVPPGFTITTEACTVYLETGETPETLDDEVTTHLEALERARGKKLGDPDDPLLVSVRSGAKFSMPGMMETVLNVGLNDRSVEGLARQADNERFAWDSYRRLIQMFGKTVQNIEGEAFEDAIDEIKREKGTENDLDLDAGDLRKLVDVYKGIVREHTGADFPQDPREQMTAAVNAVFDSWNSDRAVLYRRQERIPADLGTAVNVVAMVFGNMGMDSGTGVAFTRDPGTGEQGVYGDYLQNAQGEDVVAGIRNTVPLQDLEKLDKTSYDRLMDIMATLEGHYRDLCDIEFTIEAGHLWMLQTRVGKRTAAAAFRIASQLVDEGVIDLDEAVQRVTGEQLVHLMFPQFDTSAKVHQLGRGMSASPGAAVGKAVFDSYTAVKWSRSGENVILVRRETNPDDLNGMIAAQGILTSRGGKTSHAAVVARGMGKTCVCGAEELQVNTKRRFMTAPDGTEVHEGDVISIDGSTGRVYLGEVPVVDSPVVEYFEGTVDEADDLVQAVDRIMKHADTKRRLGVRANADTEEDAERARRFGAEGIGLCRTEHMFLGERRQHVERLILAEDDEQRDQALEALLPLQRWDFLQLLTAMDGLPTTIRLLDPPLHEFLPNITELSVRVALAESRGEKNENDLRLMQAVHRLHEANPMLGLRGVRLGLVVPGLFNLQVRAIAEAAAQLVKLGKDPKPEIMIPLVGSVQELEIIRVDAEQVLREVVEDTGEELNILIGTMIELPRAALTADQIAESAEFFSFGTNDLTQTTWGFSRDDVEAAFFSTYLEVGIFGVSPFETIDVDGVGELVRIGTEKGRATRPGLKVGVCGEHGGDPDSVHFFNRVGLDYVSCSPFRVPVARLEAARATVAQEGGSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK52</accession>
    <name>A0A010YK52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma-K factor rskA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569926.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082046_0_0_11"/>
    <dbReference type="OrthoDB" id="1972141at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="24580" checksum="B0034919B89982FD" modified="2014-06-11" version="1">MQHVDPDRLPLLALDEDFAGADDERAHLAECPTCLADYRAFQDVIELGKEVGPDDLQPPPPPLRVWQAIEAETRVERRTAAPRRLRYLLPAAAACVLGVVLGAGATLGWQAIRPAATPVDTVAASSALAPVGGGGGTGDARLIRDGERYTLEIDVRDLPLTNGFYEAWMFVPGTTRMQAMGAVRPGEVARFPLPPGLDPAGWRGIDISAEAFDGDPGHSATSVLRGELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKL3</accession>
    <name>A0A010YKL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849796.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1802"/>
    <dbReference type="HOGENOM" id="CLU_027938_4_0_11"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24692" checksum="DE6C6881D42283AD" modified="2014-06-11" version="1">MAYDLSKKVGGPILHLAFRPWVEGRQYVPESGAAILASNHLSIMDSVFLPLVLDRDVIFVAKQEYFTGTRPIDRLTARFMRNSGQLPVNRGNNRAAQEALDASLGVLKAGGLFGIYPEGTRSPDARLYRGRTGVAWLALTADVPVVPVAMLNTERALPPGSRVPRPVKVGIRFGPPMTFEDFKGQAGKARARRAVTDQIVAAIGELSGQEYVPHYAPKRNADPDADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLV1</accession>
    <name>A0A010YLV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2268"/>
    <dbReference type="HOGENOM" id="CLU_069356_24_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="20529" checksum="A65B8B1C3803CC47" modified="2014-06-11" version="1">MPPPRRSQQDRSQTTRTQLVTAGRTLFAERGYAHVSADEIVAAAGLTRGALYHHYGGKEELFAAVFENLEAEVTAEVVAALRSAPDPSAALGLGLARFLDLCARPDVVRIALTDAPAVLGWERWRAIEAAHGLGVLVDALRAAGVRHDVSTAAQLVLSAVIEAALLIAHHPDPARARAGSEQVLTALLSGLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM28</accession>
    <name>A0A010YM28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tripartite tricarboxylate transporter TctB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850500.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2318"/>
    <dbReference type="HOGENOM" id="CLU_110735_0_0_11"/>
    <dbReference type="OrthoDB" id="1583204at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009936">
        <property type="entry name" value="DUF1468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07331">
        <property type="entry name" value="TctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="18167" checksum="7EEBE01D8906E299" modified="2014-06-11" version="1">MSTEPAAPAEPAAPAEERPDRAQYGVCAFLAVVGVLVLIDAARTDPATNSNDPIGPRPVPILIGVLLLIVAVLYAIDVARGGRGEPEGGEDVDPGSPIDWRTVVLVLAAFALNAVLIEPLGWVISGSLLFWGTAFALGARRHLVSLAVAVTLALATFYGFAIGLGVALPAGILQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM50</accession>
    <name>A0A010YM50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850538.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2338"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="210" mass="22189" checksum="FC7E4147292ADFFA" modified="2014-06-11" version="1">MIRLLLADDHPVVRDGLRGMFDSVEDIEVVGEASDGEQAVLQAVALRPDVVVMDLRMPGGGGVEAIRELRHRGVAARVLVLTTFDEDADVLDAVAAGATGYLLKDAPGDELLRAVRSAHRGEAVLSPAVASRLMTRAASPPPVAASPGLSKRELEVLRLVAAGATNREAAKTLFISETTVKTHLLHLFEKLGVRDRASAVDAAHRAGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM57</accession>
    <name>A0A010YM57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850546.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_9_0_11"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="16013" checksum="D8574B18E5B36A0D" modified="2014-06-11" version="1">MLMRTDPFRQLDQLFAGIPATWSKPAVIPMDAYRLGDEFVVEFDLPGVSPDAVELDVERNVLTVRAERRPHAEQPAEMEVRERPLGVFTRQLFLGDTLDPERIRAAYADGVLTLRIPVREQAKPRKIAIAHAEPDRKQIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM62</accession>
    <name>A0A010YM62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative virion core protein (Lumpy skin disease virus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850551.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2353"/>
    <dbReference type="HOGENOM" id="CLU_037108_0_0_11"/>
    <dbReference type="OrthoDB" id="886332at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GYF_2" evidence="2">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="365" mass="39534" checksum="283836CDD14B63F7" modified="2014-06-11" version="1">MGLMDKIRGEFIDIIEWLDDSRDTIVWRFPRYQNEIKMGAKLVVRESQVAVFVNEGQIADAFGPGTYTLETRNLPILSTIKGWKYGFDSPWKAEVYFVNTRVFTDMKWGTQNPVTVRDPEFGVVRLRAFGSYAVRVADPKRLLTELVGTDPQFRTDEVAEYLRQLTVSHLGSALATAQVPMIDLAAHQQQIGQRLASVLSEELAPIGIVIPKFIIENISVPPEVEQALDKRTQMGVLGDLDQYTKFQTANAIEDAANNPGGGAGEGFGLGLGMAAGQRMAQSLNPAPAPAAGPPPLPAQAQWYLGVGGQQAGPYDQAALAAQVASGALTRTTLVWKTGMAQWVPAEQVPELAGVLGSVPPPLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMM5</accession>
    <name>A0A010YMM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mycofactocin system FadH/OYE family oxidoreductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850811.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2553"/>
    <dbReference type="HOGENOM" id="CLU_012153_1_2_11"/>
    <dbReference type="OrthoDB" id="1308229at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023967">
        <property type="entry name" value="CHP03996_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03996">
        <property type="entry name" value="mycofact_OYE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="382"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="652" mass="67198" checksum="798EE5B8D1376EA1" modified="2014-06-11" version="1">MRTPATGSLLTEAVPVAGALAPSRVVFGPHETNLARDRAPGEEASAYYAARAAGGAGVVITEIASVTPDDWPYERAPLAGSCGPGWAAIADACRPYGTVVLAGLGHAGLQGSSAYSQSVLWGPSPVADVVTRELPAVLEPPQIDAVIDGFAAAAALAVSSGLAGVELNAGTYSLVRQFLSGLTNTRSDAYGVDRCRFLRDLVASVRAAVGPDRVLALRLSADEDAPWAGITPSLAASVVDEVAGSIDLLTVVRGGHYSSTRYRPVARVEPGFNRELCRALRTVAAGRVPVVLQGSVVSPVMAQEALDSGVADLVEMTRAQIAEPRLVALVRAGSADRIRPCLLCNQACQVRDVRNPVVSCVVEPGAGHETREPAAADPGSGEVLVVGGGPAGLEAARVLALRGHRVRLAERSGVLGGALRAAATGPGRERLAAFTHWQEAECRALGVRIALHTEVTPADVAAAETPVVLATGSRSATPARAETWRTGGAVVVDVLDLLAGNAEVPPGAVLVDDPTGGPIGVGVAELLAGRGHAVHVVTPDPVLGARTPELADANFRLEALGVHRELRTRIRAVGDGEAELEHVWTGARRVLACAAVVDCGHRLPDDTFAALDDVPRAGDCVAPRTLLEAVLEGRRAATRTRGASAPRLSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNJ2</accession>
    <name>A0A010YNJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851155.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="23876" checksum="95743EEC5931661C" modified="2014-06-11" version="1">MIRVLLADDDALVRTGLRVLLEAEPDLEVAGEAATGSDAVAAARRHRPDVVLMDVRMPGRDGVWATRRIVAGPSPRPRVLVLTTFDLDQIVEDALAAGADGFLLKRSSPEQLIAGIRVVHAGDALVAPEVTRRLLTTLAGRRAPERHRLALPDPLTEREVDVLRALAEGWSNAEIAAALSVSIETVRTHVKRVLTKLGVRDRTQAVVWAFRTGFLDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPS2</accession>
    <name>A0A010YPS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851804.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108937_0_0_11"/>
    <dbReference type="OrthoDB" id="1697979at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="21799" checksum="05C74E6B45A9B2C8" modified="2014-06-11" version="1">MNLEPEKTTTVTLGGATLGAGDHLCVFHRGQEERDQLLVPFFAEGLGAGDAVLFLGRDGGKETIPALLGEHDNLQVTEPENGHLRNGRYSPDDLFVRLDDWVGRTLVSGAAPFGRTAGDMSWASQLMSPTLLPELIGEEIAVTSWLREYPLVVLCLYDLELFGGDLIIPMVKAHPKVWMAGTLVENPYYLRSAENGVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ68</accession>
    <name>A0A010YQ68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852040.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3462"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="31835" checksum="F8A3A547732F16A3" modified="2014-06-11" version="1">MATLRALECLVAVTDTGSITEAARLLHSSQPAVSQQIAALERETRTPLLRREPRGVSLTPAGRAAVADARRAIDAAASAVRSARATGEAKGGSLRLVCAQSLTVPLIAPVIRAWHRHYPHVAIGLREVVVPDGLPKLLEDGEADLLVLSGPLDGPYTSTALGDEEIVLTAPKGHRLAERRSVGLSELAGEGLVHFAPDNGLSSWLDWSLSAAGLRLEPVLRTSVTAAAPQLAAAGLGIAITPVSAVSSGFPGVVRSFSPRWTRPLFAVTLPEPDPLSARFIADLRTRGVRVPRDVKNQLEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRX5</accession>
    <name>A0A010YRX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE-like protein with response regulator receiver domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853072.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4146"/>
    <dbReference type="HOGENOM" id="CLU_000445_43_7_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="55257" checksum="C03DBFB6D2C142B5" modified="2014-06-11" version="1">MTGPESAATVLVVDDAAANRYILGTWLRRAGHRVVEAATGTEALARVDDSDVDLVFLDVNLPDLDGFTVCDRIKNNPAAAGVPVVFVSATSVGVSDRARGLSEGADAYLTEPIDPDELVATAHAMLRYSRARQRAERLARRLALLAGATLNINAARSVEDVLTAAATGAAAVFDAPAVASAVDHDGEGITVAASADRSRAYRHPAAGGYAEEGVRLVTDPPPRWRHALESSDADAPWLASVVPARPRRAPTAVALLRRGTAHEDEDRDLLSQLGQATALAVDALRSYAEERTVALTIQHSLLPRDLPPVRGAEVAFRYVPAIATAEIGGDFYEIAEVDDRLLVAIGDVVGHSLHAATVMAELRHALRAYAVDGHGPAGILVRLDAMLRRYHPGTLATVLLLMVDPATGTAVAATGGHLPPLLATAAGTDYVGVRGTILGVGQFQRPEVTFTIPDGGSIVLVTDGLVEMRGTAIDEGMEQLRQLSVPVDDDLERYCDRVLQALAASRGEDDIALLVLRRTSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV91</accession>
    <name>A0A010YV91_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="35030" checksum="7C55AB1FE3E66567" modified="2014-06-11" version="1">MRAKRTAILIGAAAAAVAAFYVRRQSSALADPRLDAMAPVPPRVDRTVRSADGTAIHVTEYGPADAPTVVLAHGWTCAIGFYTNQIRALSRDLHVVAYNLRGHGGSAVPGKGQFTTDALADDLAAVLHATVPDGQRAVVVGHSMGAMSLVALAGKHRALLHRKVAAAMLANTGVTDLVTSSLLLPGPDGLRRLTAPISRTLLAASLPLGTRPTAATMPLIRYIALAPQAPKDQVAFCAHIILETPRTVRGGFGATLGNLDLRTAVPHLDVPATVVTGEFDLLTPPKLGRRLAEDLPQARLVEIDGVGHMTPVEAPEIIEREIRALVDAHLTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX97</accession>
    <name>A0A010YX97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848558.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.818"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="20697" checksum="43AFE122E7A69A03" modified="2014-06-11" version="1">MARWEPGARERMLMAALDAFTDEGFEQATVAGIAARAGVTERTFFRHFADKREVLFEGSDLLEEVVTGAVAAAPAGLPPVELVTSAFEALGPFFAERQEFARRRLAVISANASLLERELLKLHSLKSATADALRARGLPDPDAVLTAEFGGTIFQVGFQRWMNDPAAVDIAAHIRRTSTELTALVARDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXA9</accession>
    <name>A0A010YXA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848581.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.833"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458191" evidence="2">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="55"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="34536" checksum="00F616EDF50ED05D" modified="2014-06-11" version="1">MKRMPLAVLCAATLALAACSSSKPDEEKGSAADNGPAASSQASVDKASKNYNIQFVQGVQGDEFYITMQCGIEAEAKKLGVTVKTQGPTKFDPTLQKPIVDSVVTSKPDALLVAPTDVTAMQGPLNQAKAAGVKVVLVDTTVDDPSVAVSAIASDNIGGGKAAFEAIQKLAPQGGKVLAMGVTPGISTTDQRAKGFEDAVKADSKFTYVGIQYSNNDPATASNLISAALQKDPDIVGVFALNLFSAEGTATGIKQSGKAGKIQVIGFDAGPNQVAALRAGTVQALIAQQPAEIGKFGVDAAVASLDGGSVTPKVQTGFTILTKDNIDGEGANAVYKSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXF2</accession>
    <name>A0A010YXF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_0901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848628.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.887"/>
    <dbReference type="HOGENOM" id="CLU_004848_1_0_11"/>
    <dbReference type="OrthoDB" id="25184at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022625">
        <property type="entry name" value="TypeI_RM_Rsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12008">
        <property type="entry name" value="EcoR124_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="317"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118834" checksum="AFC7951B7E1470B1" modified="2014-06-11" version="1">MSEAPGVRYEPIAISSESTVVADFLPGPAGDTSYQSEAALEREFVKLLQGQAYEYLPITTEAQLVANLRTQLEVLNGIAFSDTEWEQFFSEKIAGANEGIAEKTVRIQEDHVQVLRRDDGSTKNISLLDKKHIHNNRLQVINQYEIGKGDGGARRSNRYDVTVLVNGLPLVHIELKRRGVDIREAFNQIDRYQRDSFWASSGLFEYVQLFVISNGTLTKYYSNTTRRQHLSEQASAKKTKKTSNSFEFTSWWADAQNRPIQDLTGFTKTFFAKHSLLNVLTRYCVLTADRLLLVMRPYQIVATERVIQRIEIATNYKQLGSLAAGGYVWHTTGSGKTLTSFKTAQLASRLQSVDKVLFVVDRKDLDYQTMREYDRFEKGAANSNTSTAVLKRQLEDPSAKIIITTIQKLSTFINANKGHAIYDGHVVLIFDECHRSQFGDMHAAITKSFKRYNIFGFTGTPIFAVNSGTGGNPNLRTTPQAFGCYQHGDPVHCQREDHQMAIHTYTIVDAINDKNVLPFRIDYVNTIKLPEGVSDKQVSAIDTERALLAPERLSQVVGYTLEHFDQKTKRTQGYDYSVVANVAEVVASRNKFVELKQASRVKGFNAIFATASIDAAKRYYLEFKKQQAELTPDRRLKVATIFSYAANEDIGDDYLDEEVFETRSLDQSSRDFLDDAIKDYNALFGTSYDTSADKFQNYYKDLSLRLKNRELDLVIVVNMFLTGFDATTMNTLFVDKRLVNHGLIQAYSRTNRILNSVKTYGNIVSFRDLEEETNEAIALFGNKDARGIVLLKPYTEYYAEYADKANELLSKFPLGQPIIGEAAQKEFIALLGAILRLQNILTSFDDFAGNEILTERQMQDYRSIYLNLYAEFRKEGQGEKESINDDVVFEIELIKQVEINVDYILMLVGKWREIRGNGNDKEMSALADIQRSVDSSPTLRNKKDLIMDFVDRVSASGEIDEEWRAYVAAQRTAELDAIIADENLKPDETRTFIEHAFRDGSIPTTGTAITKILPPGSRFSAGGGHGEKKQRVLARLGEFFERFFTLSAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXL4</accession>
    <name>A0A010YXL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569754.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.974"/>
    <dbReference type="HOGENOM" id="CLU_024920_3_2_11"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="310"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="53040" checksum="640D5C3B56EFB94F" modified="2014-06-11" version="1">MTAEQVTDTLVLPKFGETVEVTPVEAPVDRQDLRRRAAVAACDAAAAVATAAALGWVLDSLPLQQALAVPAGWTITAWAVGAYHRRRLKIRLGDARGLLLTTVTLLAATSVVATLLSLSGARPLILAAVPATAVAAALSRVALRRFTRAGDALAAAPLVLYGPQDAVRRFCSAAGRDRSAPTIAAACITDLGRAGGDHASWAGGWDGPGGRGLTVVDATACPGDDPGAALDAVVDTVRRSGADTVVVTGHCDPDALRALSWRLEAHAVGVAVTPLWPVSAERVSVRTYGDATLVEVTPPRYDGARLTVRHLVDRAIAGLALVLLSPVLLGVAAAVKLTSPGPVFFSQLRTGQGGRRFRLLKFRTMVADAETLKAALATANQYTAGTLFKVRHDPRVTPVGGILRALSLDELPQLVNVLRGDMALVGPRPTATPPEQMRSDYRRRTLVKPGMTGLWQVSGRSNLPWEEAVRLDLRYVENRSLSMDFDIVCRTLPAVLSRDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYI9</accession>
    <name>A0A010YYI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849076.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1304"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="229" mass="23880" checksum="FA2219A241AE3458" modified="2014-06-11" version="1">MPVGIITGASRGLGRVTALALAARGWDLVVDGRDAAALDRAVAEFRSRGGPGTQVLAVPGDVGEPSHRATLARVARTLGPVDLLVNNASTLGPMPPLADYPLHRLASVLAVNVLAPLGLIQLLDSVDTVINVSSDAAVEAYPNWGGYGASKAALDHLSAVLAVERADLRVYAFDPGDMRTAMHQEAFPGEDISDRPEPETVVPALLRLVSERPPSGRYRASDLLAGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYN3</accession>
    <name>A0A010YYN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849156.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1368"/>
    <dbReference type="HOGENOM" id="CLU_027068_0_0_11"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458212" evidence="1">
        <location>
            <begin position="35"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="449" mass="48227" checksum="DD0852A3FE27C006" modified="2014-06-11" version="1">MVFGVPRRRAFTGAVAAVGTVILLASCSTSGSGADKDSAECEPYKKWAVEEDATVTAYSSIRDVEADRLEESWKQFEDCTGITIEHEGSGEFEAQLNVRVDGGNAPDLAFFPQPGLLASLAKEGKVKPAPAAVKTSADANFSPDWIKYGTVDGKFYAAPLGANVKSFVWYSPKTFKDKGYQVPTTWAELIALSDKIAGTGEKPWCAGVESGDATGWPATDWLEDVLLRTGTPEEYDAWVNHTTPFNSAPIVAGLDQVGKILKNPKYVNGGYGDVKSIVTTSFQEGGLPILENKCTLHRQASFYGNQWPEGTTVAADGDVFAFYLPPIDPAKGKPVLGAGEFVGAFADRKEVQAVQEYLSTPEWANSRAKIGEGGWISANKGLDANNLKSPIDKLSVEILQDPKSVFRFDGSDQMPGSVGAGSFWKAMVAWLNGEATKPALDSVEKSWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZJ7</accession>
    <name>A0A010YZJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849601.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1688"/>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_11"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="28"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="37481" checksum="A0B537380A1408C7" modified="2014-06-11" version="1">MIQLLTPDGVLDRSHELDVDLARTLYRDMARARRLDQEALALQRQGELALWLQSWGQEAAQVGSMRALADEDWVFPSYREHAAALVRGITPTELLTQWRGSTHAGWDPAAYRFHFYSLVLGTQTLHATGYAMGTKLDGRSQVVVTYFGDGAASQGDVNEAFNWAATRSLPVLFICQNNQWAISTPTALQYGAPLHQRAAGFGLRSYHVDGNDVLAVHDVTRRAAASVRAGEGPALIEAATFRMGGHSTSDDPKRYRDQAEVDAWAAKDPLIRLRTLLERSGVRPAFFADLDAELGAFALEVRAACHAIEGGDLEELFGYTYAEPHPTAEHERAAYLERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1J2</accession>
    <name>A0A010Z1J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase superfamily enzyme related to L-alanine-DL-glutamate epimerase</fullName>
            <ecNumber evidence="6">4.2.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.40" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2345"/>
    <dbReference type="HOGENOM" id="CLU_030273_9_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008872">
        <property type="term" value="F:glucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03323">
        <property type="entry name" value="D-glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034598">
        <property type="entry name" value="GlucD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00005">
        <property type="entry name" value="glucarate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="178"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634598-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="46934" checksum="7FB52412357BCB4F" modified="2014-06-11" version="1">MSGPPVVVGMEVVPVAGADSMLLNLSGAHAPYFTRTVVVLTDSAGNTGLGEVPGGEAIRSTLVEAEPLVVGTPLGRHHAVLDAVRTAFAGRDAGGRGRQTFDLRTTVHVLTAIESALLDLLGQYLSVPVADLLGEGRRRDHVPVLGYLFYVGDGAGLGYRSSAEPGWFGARDRPVRTPDDVVRLAEAARERYGFTDFKLKGGVFDGTEEAAAVTALAERFPDARITLDPNGAWSLPEAVRLGRSLRHVLAYAEDPCGAEDGYSGREVLAEFRRATGLPVATNMIATDWRQLAHAVQLGAVDIPLADPHFWTMAGSVRVAQLCDAWGLTWGSHSNNHFDVSLAMFTHVAAAAPGQITAIDTHWIWQDGQRLTREPFAIVDGEIAVPSRPGLGVELDRSRLAAAHELYLTHGLGSRDDSVAMQHLIPGWTFDPKRPALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1K5</accession>
    <name>A0A010Z1K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor 2 (EF-2/EF-G)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861862.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2366"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_11"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="740" mass="78155" checksum="102925F340B4329B" modified="2014-06-11" version="1">MAQKVAGSPDRAGSAGPVVDDPRSLRNVVLVGHSGAGKTTLVEALLVATGTIGRAGSVVEGTTVCDVDPAAVRQQRSVTLNLAPVVHRGVKINLLDTPGYADFVGELRAGLRAADAALFVISAVDGIDASTIALWEECARVGMPRAVVVTRLDHPRADFDESVAICQRVFGDGVLPLYLPVHEAVEGAAPTPGKQSLADFLGGIDGASEQTRTAGLFGLITQQIYDYSEGTPPVLRPADPEHLELIEESRNNLIEGIIAESEDETLMDRYLAGEEIDPDVLIADLETAVSRGSFYPVLPADPSTGVGLMELLDGIVRACPPPDERPAPAVTTVDGEPYDMLTADPAGPLVAEVVKTTVDPYVGRVSLVRVFSGTLRAEQTVHVSGHGVRDGNDEHDADERAAHLYSPLGTSLREVPYAVAGDLCALTKVGTAETGDTISSRETPLLVAPWDLPEPLLPVAVVAKTRSDEDALAKNLSRLIAGDATLRMDRNPETGQLVLWTMGEAHADVVLDRLRSGGVDLDTEPVRVPLRETFGGPAKGHGRHVKQSGGHGQYAICDLEIEPLPTGGGFEFVDRVVGGAVPHQYIPSVQKGVRQQMERGLVAGFPVVDIRVTLVDGKAHSVDSSDAAFQLAGALALREAATSGAISLLEPVDEVDVTVPDNYVGPVMSDLSGRRGRVLGTEPDEHERTVVHAEVPAAELTRYSPELRSLTSGTATFTRAFARYEPMPPNLVAQALGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1K8</accession>
    <name>A0A010Z1K8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ORF">CryarDRAFT_2408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2371"/>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_11"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="15"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="31974" checksum="53F89FC5332C3853" modified="2014-06-11" version="1">MSAQPQNPAGTTGTARVKRGMAEMLKGGVIMDVVTPEQAKIAEDAGAVAVMALERVPADIRAQGGLARMSDPDMIEGIVSAVSIPVMAKARIGHFVEAQVLQALGVDYVDESEVLTPADEEHHIDKWAFTVPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGNVVEATRHMRSIRTEIRRLTTLDETELFVAAKNLQAPYELVKEVAQLGKLPVVLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGDPAKRAEAIVKATTFHDDPDVIAKVSRGLGEAMVGLNVDTLPVDQKYANRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2B1</accession>
    <name>A0A010Z2B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2641"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="25266" checksum="FC0A9849722DC7BA" modified="2014-06-11" version="1">MVSRVLVVDDDPTVSEVVGRYLRRAGFLVDLVGDGPAALRAAAAAAPDLVVLDLMLPGMSGLEVCRRLRAHGDVPIVMLTALGDEADRVVGLETGADDYVTKPFSPRELALRVQSVLRRAGGSRPGASVPELEDGDLRVNPDAHLAFRNNTQLPLTVREFDLLVHFLRHPGRVFTRADLLEQVWGWTVGDQATVTVHVRRLREKIEVDPARPARIVTAWGVGYRYERTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2M9</accession>
    <name>A0A010Z2M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851100.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2759"/>
    <dbReference type="HOGENOM" id="CLU_192240_1_0_11"/>
    <dbReference type="OrthoDB" id="2056222at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="69" mass="7159" checksum="2517D5A89FAA4F94" modified="2014-06-11" version="1">MSTQPTPASLPPIGRPATRALLDAGVRTLDQVATRSRRELLALHGVGPKAVTILADALAERGLAFADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3C2</accession>
    <name>A0A010Z3C2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CryarDRAFT_3030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851383.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2988"/>
    <dbReference type="HOGENOM" id="CLU_038423_2_0_11"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="14">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EXG81908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="30231" checksum="497F06E1CA61E129" modified="2014-06-11" version="1">MPEGDTVFALARRLNDRLRGQVVRRSDFRVPRHATADLSGATLLATHTHGKHLLTRFDDPHSGPLTLHTHLRMDGSWTVLGPGKRLPRRVEPDVRIRLEFADGRSAAGLKLPVVELVRTADEGQLTAHLGPDPLREDWDRDQAIARLAADADRPVSATLLDQTRMAGLGNLWVNELCYLRGLSPWTPMRDVDVPTLVDLAARLLRFSVSTPGAMQVTTGDTRPGNSHWVSGRAGRPCRRCGTPIEVVAEVSGDPERRRTWWCPRCQPGPGPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3F0</accession>
    <name>A0A010Z3F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851428.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="182"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="32128" checksum="B7FFB91B1578A738" modified="2014-06-11" version="1">MSGDGFARLVEPLRGELHAHCYQLLASAHDAEDAVQETLVRAWTARDTFTDRGAGVRPWLYRIATNRCLTLLAKRARRELPADVGPASDPHWVEPYAQPEGTVLARERLELAFVAALQHLPPLQRAVLLLREAQGFSAAEVADLLGTTVPAVNSALQRARASLPVTEPSAGPDDPGVRELARHYAAAWEAGDLDTILALLADDARYSMPPEPAWYAGTDAIRGFLLAGPLNVAWKFRATVANGQPAFGTYLLDGDVYRPGGLDVLTVRNGRISEVVSFLTADLTSFGLPDEFGPSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3W5</accession>
    <name>A0A010Z3W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851649.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3178"/>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_11"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="53"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="477" mass="50539" checksum="EB7166FE07323C6D" modified="2014-06-11" version="1">MRTLVTGGHVVTMDPALGDLPVGDVLIHDGEIVAVAPKLDVTDAEIIDATGQIVLPGLVDTHRHTWQSLIRGICGDWTLGDYYFGIRLAISPAYTPDDVRLGQLLGAVDALNAGVTTLLDFSHCNNTPDHSDAAVQGLQEAGIRAAHCHGFFESSPMAPKFGTHADRLRDYHRIADTYFPTNDGLLTLGVSLSEPFGVPWQQTLDELAIARERGALIVNHTGCVWGSALTFGVTELDALGMLGPDIVHVHCNALSDPEWKALARTGGKVSISVETELNMGMGRPVFAACRQYGLAPTLSADVISLNSGDLWHQMRFGLGFARWDATHQQNLAGEMPDAVISTAKDALTWGTVNGADALGLGDRIGSLTPGKRADVVIVGGGSFEQHPRTDVYGTLVFQTTVADVRTVLVDGRVVKQDGELVDHDLAGLATKADAAAAGILARVTDAGATLPGTPPGAWAAIEPMAQEFLADARRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z403</accession>
    <name>A0A010Z403_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851703.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3217"/>
    <dbReference type="HOGENOM" id="CLU_060077_8_2_11"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15795" checksum="CF8B750AC5FEDDBE" modified="2014-06-11" version="1">MVPIQEVARRSGLPEATLRYYERIGLIAPVPRDESSGHRRYDPDIVQTIEALACLRTAGMGIDDMRAYLRGMSDAPDAAGRQRELFEKHAARIAEQIDTLRSRQRYLEAKVLLWGSRERGDGAAEERAIDEVTRAASELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4C6</accession>
    <name>A0A010Z4C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3347"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="73"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="522" mass="54764" checksum="5B0FB1DDDD7AF1B3" modified="2014-06-11" version="1">MAVTAALALAACGGSPGGSGSSGTPQSGGTLTFAVGSDQGCVDPQQVGSNDSIYSLRQTVDSLTDQDPRTGRIVPWLAEKWEVSPDAKTFTFHLKPGATFSDGTPVNAAAVKADFDAVPTLGVKAQLAIGYLSGLDETKVVDEHTVEVSFKQPNAQFLQATSTFSLGIVSPASAAKTPDQRCTDGIIGSGPFVLDKYVANQSITLSKRKGYDWGSSLWTKKGEAYLDKLVFKVVPEAGVRTGSLQSGQVDAIGSVGLADESALKAGGVELKARANPGLVFGLTFNNSRPIAQDKAVRQAIVAAIDRQQIVETVFPTGSKPATSVLAGTTPFYTNLGSKLAFDASKAKSLLDGAGWKPGADGIRAKNGTRLSLTVTWAANAGTNQPTLELLQQQLKAVGVELELKEIQIATFPQVLSSGSFDVFWGNATRADPDILRSSFSTKLANFYKVPPSELDDALAGAAATVDAAKRQTLVTQAQNLLVDNAYTVPVVELTTELGVGKNVHDLNFEASSRIQLHDTWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z517</accession>
    <name>A0A010Z517_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852248.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3590"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458250" description="Histidine kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="233"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="476" mass="50624" checksum="66F0CF19813BB3AC" modified="2014-06-11" version="1">MTRRLVLGVTLTATLAVLVSQAVGLLVVRSWLLERVDHQLSALRPPPGIVPVPEQPAGALPSEFRIYFYDGAGRLVGKSDATGPALADDRQHLDVAFGRPVTVPAADGDGRWRILVRTLSDGTTGVVALPLDTVNGAASKLLWIDGLLLLFTVGGLLALSRWVVRLGLLPLSRVERTAEEITAGRLDLRLPDTDPSTEVGRLGRVLNSMLDRLRNALAEREASETRLRQFVADAGHELRTPLTTIRGYAQLGLRDDEEGYRVIAESSARMALLVDDLQLLATLDREPAYERGQVDLLSLAADAVSSIGVQSPAHPIDLGPLRGVPAFGKKPELEVVQTVGDPRRLRQIVDNLLSNAVRYTPTGTPVHVRLGTARAGALTGGTDRPGRVGASAPLPVGTPICVLEVADEGPGLAPDDAAHIFERFYRADRSRSRGLGGSGLGLAIAAVIAEGHGGRLELDPVPGSGCVFRLVLPDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5N7</accession>
    <name>A0A010Z5N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852592.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107911_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21734" checksum="6BC96D62A7AC03AD" modified="2014-06-11" version="1">MAPATRRQDSAAYTRTVILEAALDLFCAHGYASTTVNDVAARAGVAVATVYTSVGNKTTLLRTLVQRSANATEIDESVATAAAAADPRGIIGLVAAATGDGHEKYARVIRLMFETATTVPEIADETERVVSGYRANLRISATRLQELGALRAGTTVESAVDVLWFYFGLYSFPTLVRDNGWSYDRAKEWLADRAAEVLLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5W5</accession>
    <name>A0A010Z5W5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852644.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3882"/>
    <dbReference type="HOGENOM" id="CLU_087194_0_0_11"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="93"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="31507" checksum="3BCC69BE15A1201F" modified="2014-06-11" version="1">MINTSVYTDEQRRHFLRYTRTRQWPMLGRFPVAAPRHTELLAGMLSCPVAVVEDLIASLADEARATAAELLRDETYRAALGSLPYRPGDRVVAVGDSITADRLGWFELLRTSLELGGADGPTLVNLSVSGDTTADVIERFDLLQAAEPSRVLLMLGTNDARAHGRAGGYRMATTAETGRNLRALRHLITRDLGADVTMITPTAVDQARVDATFADAPVHWSASAVAEIAAAVRDTDPGAVDLHEATRTAAPGHLQDDGVHPTVAGQRFILTHLLEHLAAPTRHGSGWGAAAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5X3</accession>
    <name>A0A010Z5X3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_8_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="2">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="39920" checksum="DACE67787489AE4C" modified="2014-06-11" version="1">MAVVLLVTHGSGGDVLPFVRIGAALLARGHDVSLLTHAPYAERVRAAGIEFVPIDTEASARERRLSLDVRGPAELRRHYESTGLFTQLDLEVAALIERYRPHDTVLVGRHTSALSTLIAAEALGAPAVTVAVAPIQLLVAPAAALNLARGLADGVGAVRARHGLPARPGWLRWLDSGTRTLGLWPSWFDAAGPPAPPGVDLVGFVTGDEDDPAGTTETLDHTEVLVTGGTGAMLHPRFYTLALDAIARAGHPAVVVAPDRAMLPARLPPHTRWYPRLPFPAVVPQAGALLHHGGIGTAVRALRSGTPQVILAHGADRPDNAARLARFGLARWTEVEEASPESVADLLDTALASRPRRAGGDPARSSETAADVIEKTVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6E5</accession>
    <name>A0A010Z6E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065853_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="22969" checksum="36B13C3D94B6FE26" modified="2014-06-11" version="1">MGARIPAPNVVGMHTRADYAWPADDAELARLVEAHPWVTMISDGLVVSHLPIVVDHTADRLTLLGHLSASDAAQHRLGRVDTVLVVAGPHGYVSAGWYVHGPSVSTWNYVVAHLHGRPSALGPEQTLDVLTRTQDHFESGRPDPYLTARVAGYAAKLTPYVTGFRLVPSRVEAKRKLSQDKPAEDVAGVLHGLEDPMDLHANPALAAAMRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6H5</accession>
    <name>A0A010Z6H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional activator of acetoin/glycerol metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570701.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4080"/>
    <dbReference type="HOGENOM" id="CLU_583776_0_0_11"/>
    <dbReference type="OrthoDB" id="685227at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="341"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="449" mass="48757" checksum="F2626D503909D68C" modified="2014-06-11" version="1">MHYGSVYAAWEQFIRGDDHVLGVRPEVAISWHRCREQYRVDPHLTEAPIAVAEIDHTPEHDVVFAELGFRAASLAHDVSVAGGVVTICDATGRILAEWGDPATVERAEQANLAPWFCWSEAAAGTNGMGMALEAHGPVLVRGAEHWCRAFHDWVCAGVAVRDVVSREPIAVLNISCFRNQLPAMAGSWLANAATKTQCLLRGRARDSAAELVAAYTQARAGSTEALAAVDTAGKVVIADETASALMGVPARVPALDPTVRWTPGLPELIGAARYAARQASRNPDYIGSTQVFTYLTDEPTPITLRPVFLSSQLIGMLVCFGGSEEPQPPAEPSTRNLPRRVVATRENRTVLLRLPEVSFAESEGNEVWLSTDQGRLRSASSSLDSLGDELAPAGFLRVHRRYVVNLGRIREVERRRGGELFLVMDDDAVDGMVPVSRRNASAVRRALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6S7</accession>
    <name>A0A010Z6S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853266.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4198"/>
    <dbReference type="HOGENOM" id="CLU_056175_2_2_11"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="30768" checksum="7941C9F40FD0EDEE" modified="2014-06-11" version="1">MSGALSGFAAIGVLIAIGYLLGRRGTLGPDARAVLARLSLTVATPCLLFTTVTSADPSLLTAPTSVVPLLTCLLAMVLAVVAGAVRRWRGEVRVMTTIAVGFPNLGNLGIPVASYVLGDAALVAPLILFQLAVQSPIAMTTLELRGAGETRGAVRRALANPVLIATVLALAVVFTGLRVPWVVAEPVRILAQMAVPAVLLSFGLSLVGSPLPGRGGDRAALGFVVVSSALVRPVAAWVLAGPVLGAPAATVYAAVVLSALPVAQNVAVWAGHYGAAPRLARESVLLTTIVAPVVIVLATALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKZ7</accession>
    <name>A0A010ZKZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847862.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.317"/>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="112" mass="11799" checksum="05F64D1328C7D863" modified="2014-06-11" version="1">MELSLTTRAVGRHTVLAVGGEIDVYTAPQLRSELIRLADAGFAHIVVDMERVDFLDSTGLGVLVGALKRARAAGGSVELVSSQPKILKIFNVTGLEKVFNIHASVDEAVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLN3</accession>
    <name>A0A010ZLN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_101_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="234" mass="24574" checksum="A08783BB81BE7F3F" modified="2014-06-11" version="1">MTVQPVARPRIAPQRARSRPPASTPAASGATISVEVAVAGPEALETATKLAGQIRDLVDAANAGAGSVAISASVGLEVGAGNRAGRPALTQVGRTGWAPAVPLPAFVAPAPVPVEPAVKVAPVVEKSPVVAAAPLQIFPARRVALLDGVQLQLTRREFDLLVFLSEHAGRVFDRPQLLRLVWGHQVICGERTVDVHIRRLRAKLERTGPAISTVRGVGYRLDAAERVAVVHERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM96</accession>
    <name>A0A010ZM96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569713.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.792"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="34318" checksum="6AD53129CC9201C3" modified="2014-06-11" version="1">MAVPTLIAPAPRLAPSRGARPRRRRRVTENLTAYAFLAGGLLCFGLFSWYPAVRALMLAFQQSNSVDSATWVGLDNFRLLFADPEFGAAWRNTFTFTGLALVIGFAVPFALAVLLNELRHAKTFFRIAVYLPVMIPPVVTALLWKWFYDPGPGLFNEALRFLHLPTSNWTNSTSTALVSLVLVATWANLGGTVLIYLAALQGIPGELYEAAELDGASLWQRIRHVTIPQTRFVMLMLLLLQIVATMQVFTEPYIMTGGGPEDATITVLYLIYKYAFVYLDYGSACALSAMLLVFLGAFSAVYLRLTREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZME4</accession>
    <name>A0A010ZME4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848610.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.859"/>
    <dbReference type="HOGENOM" id="CLU_010194_4_1_11"/>
    <dbReference type="OrthoDB" id="1135906at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29235" checksum="9858459E0BDD796D" modified="2014-06-11" version="1">MNQPAQQQDVPGTQSEMTPRPDCGESSYQGTGRLAGKAAIITGGDSGIGRAVAIAYAREGADVLISYLSEHEDAKDTAKYVEDAGRKAVLVAGDVSQAQHCRDLVARAVEEFGRLDVLVNNAAFQMTHESLDEIPDDEWDYTLATNLSAFFHLAKASVPHMGPGSSIIGSSSVNSDMPNPTLAPYAATKAAIANFCASLAQMLGEKGIRVNSVAPGPIWTPLIPATMPPEKVAKFGENTPLGRAGQPVELAPVYVLLASDEGSYISGARVAVTGGRPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMU2</accession>
    <name>A0A010ZMU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848764.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118533_0_0_11"/>
    <dbReference type="OrthoDB" id="1946927at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="21204" checksum="7F7D25203A4E82EB" modified="2014-06-11" version="1">MAHSGGVDDRWESLFADAEAQFESLRRGEVEAEAADRSRREFALVRFVDRLRGAVGVAVEVWLDAEPGWAGEPARGVLVRVGPDWLLLGGEGRREVLVPLAAVSAIAGLPGRTALPGAGGKVEAKLDLRYALRRLARDRIPVRVALRGGRATWGTFDRVGRDFVELAEHLPGEARRAAAVRSIRSIPLGALRAVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP04</accession>
    <name>A0A010ZP04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1465"/>
    <dbReference type="HOGENOM" id="CLU_052338_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="34331" checksum="0D6C80E5508CD6BF" modified="2014-06-11" version="1">MFVMPGSAAPSTLAPLHLVLGDESFLAGRVVADVVAAARAADPECDVRELDYTQLTPGALPELFSPSLFAEARVLIARDAHTVGKDLAAALLQHATALAKDPSSGIILVVTHLGQARGKALSDGLKKAGAETTTVAKITKHREKVGFIRDEIRRAGGKASEEVASLILDAVGPDLRELASVCSQLVADTGGRVDLDAVRQYHRGRADVTGYTVADAAMIGDTAGALEALRWALAIGVDPVPIADALADGVRSVARVAGARGSGYQLASTLGMPPWKVERAQRQGRGWSPAGLATAARVAATANADVKGGADDRNYALERAVLAIVSAREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP25</accession>
    <name>A0A010ZP25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_1513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849318.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1486"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_2_11"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458240" evidence="10">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="205"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="437" mass="47468" checksum="AF5F041280076F37" modified="2014-06-11" version="1">MSTPGLLAVAVGLVVVAGAVAAADTAFNQISRARAEEMLRAGTRGAGNLLALVGNLPVHVSLLLLIRLACELTATTLVAIVAIDRWGPGWVAGIVTAASMTVVSFVLVGVGPRTIGRLHPYPVALASAGITRWLGRVLNPLARLLILVGNMVTPGRGFREGPFATETELRELVDLAEERGVVESEEREMIHSVFELGDTIVREVMVPRPEIVWIERTKTVRQATSLALRSGFSRIPVLGESIDDIIGVVYLKDMVRRVQGQPEADRQLRVEQIMRDAEFVPESKPVADLLREMQQRRIHMAIVIDEYGGTAGLVTIEDILEEIVGEIADEYDNERPPVENLDDGAVRVTARLPVEDLGELLDVRLPDYSDDIETVGGLLAHELGKVPIPGASVRIQNLELTAESAGGRRNRIDTVLVRRHEPEPAESPAEETHTADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPT7</accession>
    <name>A0A010ZPT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1744"/>
    <dbReference type="HOGENOM" id="CLU_077168_4_1_11"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18024" checksum="87413EB276A3DF12" modified="2014-06-11" version="1">MRNLVVVMGVTGCGKSTVGKLLAERLGVDFAEGDDLHPQANIDKMTAGHPLTDEDRWPWLAKIADWLADHAAEGGVIPCSSLKRSYRDRLRQGAPDVWFLHVDVDRDTIVKRVSERKGHFMPATLVDSQFATLEPLVADEAGAPIDGTQTPEEIVEDALRRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPW8</accession>
    <name>A0A010ZPW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly protein, ATPase CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1776"/>
    <dbReference type="HOGENOM" id="CLU_005379_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="117"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="54337" checksum="C3591E392EB57C0A" modified="2014-06-11" version="1">MVFLPPSVIEPSPRRLPPPPAHLQGGPRHAAPISAVDYAAVRLLGRQISERLSTWLRNHPDAAEDDRRRERDRVAGQQVVEWVDAQRRAGVPLGAADERALLDAVIADLVGLGRLQALLADPTIEEVHILGCDRVRITRRSGAVESGHPIAESDDEMVEILQTAARRAGSTERSLSTSRPVLDLQLPDGSRLAAVYQVSHRPYAVIRRHSTLDVTLPDLAGGRGDLSEMIDPLMGEFLSAAMRAGLNIMVAGLAGAGKTTLLRALAAEIPRQEAFVVLEESRELGLHASPRHPWAMSFEAREGHGERDFSGRPAGEVTIADLIPLSLRLGVLRVIVGEVRSREIVPMLQAMTTSRGSMCTIHARTPQAVTERIIELSLSHGKDMTVELARRMAGNALDLVVYVTVQDETPIGGRKHRFVSHIEEIDGVSGDRVATTTVFGPGADGRGVPKHLPGRTRDQLLRVGYDARALAGWIEAGHGAWRQPLDSLLNRVPTTTAGVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ36</accession>
    <name>A0A010ZQ36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2011432_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="13152" checksum="97C0B52E81BBEBFF" modified="2014-06-11" version="1">MTGRSPIAQDESTGWDSAGQLRCEPSRFGYRIVLVGEVDLTMSQEWEPIFGVLSDGEPSDVTVDLSAATFIDSSVLGAFVRLHRTVSARGAELTMTGAEGSVLRTISLAGIDRLIPIVPVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQH0</accession>
    <name>A0A010ZQH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MobA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.477"/>
    <dbReference type="HOGENOM" id="CLU_061980_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="19486" checksum="E92918232C03CA1D" modified="2014-06-11" version="1">MRPGLRYVLVVDVVGIVLAAGAGRRFGRPKALVEYQGTRLVDRAVSLLSTGGCSPVLVVAGAAPLTVEGATVVDNPDWESGMGSSVRAALSVADAAAAVLVPVDTPFLGADAVRRLIAAYRAGASVAAATYRGERGHPVLIAAEHWPAVIASARGDVGARAFLRANPSLITPVPCDGTGRPDDVDTPEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQI5</accession>
    <name>A0A010ZQI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine reductase, riboflavin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850068.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1999"/>
    <dbReference type="HOGENOM" id="CLU_036590_7_2_11"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="25192" checksum="F86CFF8B8FE6992C" modified="2014-06-11" version="1">MRLLHPAAAELDDVALEKLYATDRSVPRLRMNFVASVDGGVSVDGLSAGLQSPADKRVFKLLRGWCDGLVVAAGTALAEDYGPVTLDAERRARREAAGLAPTPTLVVVSGSLSIPPDHASLVRAPVRPIVVTGPDAPADRRRAIEEVADVVDDVDFVAALHARGLSQLLCEGGPRLFASLTAADDVDEICLTISPQLAGGGPGRISAGPHSPDPRSLALAHVVEDEGVLLLRYCRPSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR01</accession>
    <name>A0A010ZR01_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4111 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850283.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2167"/>
    <dbReference type="HOGENOM" id="CLU_082941_2_0_11"/>
    <dbReference type="OrthoDB" id="1607767at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="DUF4111"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="DUF4111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4111" evidence="1">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="27841" checksum="C7999934A72818BF" modified="2014-06-11" version="1">MDTELTTFLTELVADVRGILGGTFVGAYVQGSFALGAGDLHSDCDVVVATTTLPTGPIETGLRRLHAVVPDRPGFWSTHLEASYADVETLRSVRGLGTRWLYNDHGHRTLAWDTHCNSAHTRWILHNHGITLAGPPAASLVDAPPPGALRDEARAALPHLVAETRTWAPFDVAWTQRYLVTTYCRLLYTLSTARVASKRGALDWALATLDPAWRPLLTQVREDRALGWDPEAGPRPGSLDTTYAFGRYAESFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR53</accession>
    <name>A0A010ZR53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850350.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071354_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="34465" checksum="126888F393FEA46F" modified="2014-06-11" version="1">MTSLADVDLAATLDAYAEGLAYVARSPVLRTPADEGLEYQDLTYPSADGVPLEAWFIPCAGSDKLIVAMHAFGFSRYGFPSHVEPWKSAFGPGNDTEINFIRDYQLLHEAGYNVLAFDFRNSGRSGEANGRLSLSTLFEARDVVGTMRYVRSHPELSGMTLGIFARCMGANATFRALHTDPAEFDDVRCLVAPLLLSPRVYLETRLESVGLAEYADEVDHRYHLITGGRLTDGYTRAWAPSVLVPTLTYGVHDDVITKPSDLEETYEAIGAAVKDMFWIHDTPSRWDGYKWFQRHPDRILDWFATHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS31</accession>
    <name>A0A010ZS31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM peptide maturase, mycofactocin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850809.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2552"/>
    <dbReference type="HOGENOM" id="CLU_009273_4_3_11"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023913">
        <property type="entry name" value="MftC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00316">
        <property type="entry name" value="C-terminal_tyrosine_decarboxyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03962">
        <property type="entry name" value="mycofact_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="423" mass="45342" checksum="44AF8CC7BA3B334C" modified="2014-06-11" version="1">MTAPTATRLIDHFKLGLDAPICLTWELTYACNLSCVHCLSSSGRRDPRELTTAEAKAVIDELERMQVFYVNIGGGEPTVRSDFWELVDYATEHKVGVKFSTNGVKISPEVAERLAASDYVDVQISLDGATAEVNDHVRGPGSYATAVRAMENLKNAGFSGFKLSVVCTRQNVGQLDEFKAIADRYGAQLRLTRLRPSGRGADVWDELHLLPHQQKELYDWLVAHGEQVLTGDSFFHLAAFGDALPGLNLCGAGRVVCLIDPVGDVYACPFAIHENFLAGSVREPGGFQGVWRDSELFRELRQPQTGGACQSCQHYDACQGGCMAAKFFTGLPLDGPDPECVQGYGESALAGVVAGSAPKPSLDHSHRTTRKSRPVALTLSRRPPALLPQSAPPGRACDESPLSGFELIGPSSGSGCASGACGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSA2</accession>
    <name>A0A010ZSA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L11 methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2637"/>
    <dbReference type="HOGENOM" id="CLU_071058_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="22646" checksum="15C505CD8A52D6BB" modified="2014-06-11" version="1">MTSAARLYGEGITALEAGRPHRLLIRHERGGLAPLALDDWHRPARPGDRSLLARCAGSTLDAGCGPGRLAAALALAGRPVLAVDIVPAAVAAARRRGAAALRRSVFGRVPGAGRWTSVLLADGNIGIGGDPVRLLRRVAALMGAAGRVVVELAPPGAGRRYRFRLEHDRRYSEWVPWADLGADEVHRVGAAAGLVVDEEWVTAGRWFATLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSN7</accession>
    <name>A0A010ZSN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CryarDRAFT_2828</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862241.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2790"/>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_11"/>
    <dbReference type="OrthoDB" id="1584770at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="40"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EXG81709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="698" mass="75188" checksum="D4AB04363F5CED92" modified="2014-06-11" version="1">MPAERHPDQGAPKTVSPTGRTEREGLLGGDPRAQAGDHLTTAQGLRLSDTDHSLKAGRRGPSLLEDHHLREKITHFDHERIPERVVHARGAAAHGTFVSYGNAASATKAGFLADKGKETDVFVRFSTVLGSRGSADTVRDTRGFAVKFYTDEGNFDLVGNNIPVFFIQDAIKFPDVIHAGKPHPDREIPQAQSAHDTFWDFVSLHTEATHHVFWNMSDRGIPRSYRTMEGFGVHTFRLENAEGETVLAKFHWKPVAGVHSLVWEEAQIAAGVDPDFHRRDMADSIENGAFLEYELGLQLFPDTEDETFEGIDLLDPTKIVPEELAPVQLVGKLTLDRNPTNYFAETEQVAFHLGNLVPGIHVTNDPLLQGRLFSYVDTQLTRLGGPNFSQLPINRPHVPVNDNLRDGMHQTAVHRGLAPYLPNSIDGGGPFTSEEGYVEIPRTISGQAVRENPASFDDHFSQPAMFYHSLTPVEQVHIIEAFTFELGKCYEQAIKERELEVLAKIDTGLCEAVAAGLGLPAPAGEPVAHGPLSPTLSQIPAEPGPITGRIVGVVAGPGADLDGIGTLRKAIEGAGAVVRVIAPHGGNLGKEIVERTFLTARSIEFDAVVVASGVAETPDAGDIKARILLLEAFRHAKAIGAWGDGAKVLAGAGIAPGPGVLLGDAPDKEFVAGLVTALGLHRAWDRADAVMASEVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSP7</accession>
    <name>A0A010ZSP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1286"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="509" mass="54504" checksum="50D840F0CFAA65F4" modified="2014-06-11" version="1">MTVTAATGSTLPQLAERSWERLGQESVQIFEGRTWTAAELGARSRRFAAGLLAAGLRPGDRVVVCMANCPEVGVAYHGIWWAGGVTTPVLFLLSDAEIAHILRDSEAAFVITTPEFLPKIQNAAAGIPTVRGIIVAGEGSGALDFAELEAGDEAPQVSRVPSDLAGLLYTGGTTGRSKGVMLTHDAMSAAAWAMVHNSDEDDDLQVALLPLPLSHVYGLTVSVTAVHATTPRTGVLMRWFDPVGWLQLAERHRAQLGAVVPSMLQLVMAQPMEDYDLSSLRRIASGGAPLPAQVAADFVKRLPQVEVYEGYGCSELAGGITAGKPGRPVPVGSVGVPMPNIEMKIVRPDGTPVDPGEDGEICARGPMMMSAYWNATDETAHAIQDGWFHTGDIGHQDAEGNLFVVDRIKDLIIRDGFNVYPRDVEEAMLTHPDVALCAVVGRPDPRRGEEVVAFVQLGPGATVTTEELIEHGKARLAAVKYPRDVRIVEQIPLTSVGKLDRKTLRRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZST9</accession>
    <name>A0A010ZST9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1308"/>
    <dbReference type="HOGENOM" id="CLU_060254_0_0_11"/>
    <dbReference type="OrthoDB" id="1270181at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458267" evidence="3">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="28077" checksum="42AF6FCDD2B5D99D" modified="2014-06-11" version="1">MRGKGRSGWTLGVAIGGTALALTGAALVGTSSASEEASSASSASVGTISCPDVEGKLPAVPASAQAEVDRNLQLLQTQISEAQNRLETTVGQGGKNFVQNAILGPLADKRKSTIDRIEISIGRTAARPDLGADALSVCSVQNGDAPSADPANEAPPAEAPEAPETSAPPADGGDNGGNSAGQQISCPDVESQLPAIPAQAQAEVERNLALLDTQINEAENRLVTSEGEGGANFVQNAILGPLADKRVATINRMQTAIGRNAPRPNLDVESLSVCSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSW1</accession>
    <name>A0A010ZSW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725671.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1336"/>
    <dbReference type="HOGENOM" id="CLU_061970_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="31572" checksum="C47BEF9CE5D319B7" modified="2014-06-11" version="1">MSLDDIADELYGLDPASFTAARLAREKEARAAGDRDLAAQIKGLRKPSMSAWLTNQLMRERREQIEPLLALGEQLRELQASVSAEQLRALTQQRHRLVYAVAQEARSLGHERGQQITDAVARELEQTLHAALGDPAAAEAVRSGRLVSGLQYAGFGPVGSAQAAPAPRPAAPARQDDLAAKRKERSEQLQKARAEAQEVLDRARASLVDAEASRDEAASAAAEAEERFTEARDRVDQLKLDLDDAEEAANAADHELKAARRTAEHARKAAQLAAQRVTGAEYRLNELPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTA4</accession>
    <name>A0A010ZTA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3018"/>
    <dbReference type="HOGENOM" id="CLU_1052585_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="29203" checksum="DEE5A18A8945ED5B" modified="2014-06-11" version="1">MDEITELIERWVLAVGAGDLDAVVADHAEDIVMFDVPPPENGVRGLDAYRESWPPFFAWLRSGAVFELVSLEVTAGEDVAFAAALLRCGEPGDVAERRLRLTLGLRRENGRWVVAHEHHSFTVSDSADGVEALHRRWFDATEAKDLDAMMAGIADDVVSYEHEAPLRYVGVDAVREVCATGLDSSTGTVTWDVPDLTVVVRDDLAVAWGLNRMTAEQPDGTVAENWSRGTRVFRRVAGEWRMVHQHVSWPTDPDTGEARLDLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTT1</accession>
    <name>A0A010ZTT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1677"/>
    <dbReference type="HOGENOM" id="CLU_119287_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16991" checksum="5067A97FACF13383" modified="2014-06-11" version="1">MLVAMTSAHRLAHFNVARLRAPLTDPVMSEFVAGLDAMNALADASPGFVWRLAEGPEGDATTVRPLDPDVIVTMSVWDSVEALRTFSYRSAHLDYLRRRRDWFRPHDLPASLVLWWVPAGHLPTVEEACERLALVAGGASPKAFTFREPFPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUJ9</accession>
    <name>A0A010ZUJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849989.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887494_0_0_11"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="28796" checksum="3C5767B686DFA110" modified="2014-06-11" version="1">MTARGLCAVVLAAGAGTRLRPLTDLLPKALCPVGNVTLLDRALNQLETLGLSGPDLVAVNAHHHADQVVAAVAGRATGSVEQPEALGTAGAIAALRDWVSGRDVLVINADAYLAGPLPGEFLGGWSGERPRLLVVEAGERRRDFDEWRFAGISLLPATEAARLRPEPTGLYEVVWRAARAEGHLELTPFVGTFVDCGTPTDYLTANLHARTADASDPAGIDPSAVVTGEVTDSVVGAGAVVEGRITRCVVWPGARVEKHETLTDVVRAGDGLTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV22</accession>
    <name>A0A010ZV22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852414.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3701"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="11"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="50441" checksum="DFBB7C92BBF6663F" modified="2014-06-11" version="1">MSTEFYIGGSWVDPAAPRTLGVLDPATEETFATISLGTAADVDRAVVAARAAFATYSQVSVEQRREYLERIVAGFRARLPEIARTMTREMGAPITFSTQRQATVALFHFEEAARVLADYRFEEEMGAGIVRREPIGVCGLITPWNWPLNQVASKVAPALATGCTVVLKPSEIAPLSAMVLAEVIHDAGLPPGVFNLVNGDGPGVGEAIAAHPGIDMVSLTGSTGAGVRVSQLAAVTVKRVALELGGKSANIVLPDADLESAVVAGVHSCFTNAGQNCQSPTRMLVHRAQRDEAYAAARRAVAEVRLGDPLDESTTMGPVVSRVQREKITALVRSGIDEGATLVVGGPERPDGLDQGFYVRPTVFGDVTPEMRIAREEIFGPVLSILLYETEDEAVEIANDTPFGLAGFVQSADPDRARRVAHRIRAGRVYLNGAPFDRSLPFGGYKQSGNGREFGRFGFDEYLEVKAMIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV36</accession>
    <name>A0A010ZV36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3717"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="835"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="898" mass="93067" checksum="D3B8612F89189927" modified="2014-06-11" version="1">MLLGRGRECEALDGLLRDVRAGRSRVLVLRGDAGIGKSALLDHVAGRAAAGRVVRVAGVEVESDIAYSGLQQLCGPLLPHLGALPGVQAAALSTALGLSAGSAPELLPLGLAVLSLLAEAASERPVVVVVDDAHWLDRMSGLILGFVARRLDAEAVALIFATRQPSDEPTLGGLPELRIGGLPDGPARTLLNSVLPEPVDAAVRERILAEARGNPLALLELPRGSTSAELAFGFGGHRPTPIAGRVDEGFRQRIAALPAETRVLLLTAAVEPTGDVPLLLRALQLLGVKISAAEPAATAGLLELGAGVRFRHPLVRSASWRSADATLLRAVHAALADATDPADDPDRRAWHRGHATLEPDEEVAGELVAAADRALARGGRAAAASFLERAVVLTPDPQRRAARVLAAARAHLGAGAAEAVADLLAAAELGPLDARQRAEAGRLRASAAFLVDPSGRSGPPLLDAAAGLATLDEAAARETAVMAFVAVLQGGRSGDPDAVRRTAEAAGTLPRGDDPAGRLVDGLVAWSLDGPGPAAPRLSAALETITAADDPEVLWLSASVALDLLDQAALDRLTRRGLDSARRTGARSGLPGALSGRSEALLAAGRLVEARSLLDEARTIAEATGRPSHLGTEALVAAHQGREKDAEEAIAAAERAAASTGVGRLIGVAALSGAVLRNGLGHFPAALAAARVGTAFPELSLYPRVLSELAEAASRAGVPAAVTEARDRLAERAAAGTPWALGAHAVAEALTGPAPAAEEWFRAAIAHFDVDLLAFPQARARLLYGEWLRREGRRVDARAALRAAHEAFAAMGAEAFADRAARELTATGEIVRKRSADARDELTSQEAQIARLALAHRTNAEIAAMMYLSPRTVEWHLRKVFTKLGITSRRELAAVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVX7</accession>
    <name>A0A010ZVX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570064.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2436"/>
    <dbReference type="HOGENOM" id="CLU_010663_0_0_11"/>
    <dbReference type="OrthoDB" id="91876at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="943" mass="104789" checksum="AB1DF35E9A484B90" modified="2014-06-11" version="1">MNAAPRNAAPPSTLPTHPASVAVAPPARMPSRPVTGIPTSAPPQSSPPAPLYVPAPERYPAIDPPESDDAKTARDERRQKKRKPRRVRSRPPKEQKDRQAVHELELREIAGHLTFTRNDVTAWYHLPDIQWAFRADKERTSILLGIAAQYAALGGYRLHMRRTNRPYPAVGWARRMAALTPHPVPDVRGAPSWSDHLEAGQRRLHATSLAEGEVYLGVVFQRRTMREQMVETLNALRKRGSGNAERARLEQLVGRFDEVLGAFGMQARPATSKQVEWLIHRSVALCMPPPPALSPAEAGGWETGDLLAFTEHTMRYRSPYGSTVKLLSRIGDEHVERHVAVLTFGRMEELSIPERHEPWLHFHEQLPWPMELSSRVDVLGQGDALRSLEHKLLTIRSQQRDYHEHEMDAPPELERLAQRALDISDEMSTGLDLDAARVHGWHRIAVSGRTEEECLKRVRALTDHYRSMRITLNHPRDQLRLLDEFIPGQPVANTGYLRRMPAKYFAASIPQAAAAIGDRRGPIIGETCGTSHRPVMWDPHYATEVRERSGLTVFVAEPGGGKSTLMGGIAYLAARRGVQCTILDPSGPLARLATMPELAPYSKVYNLTRGEPGTLAPYGLIPTPRREHFASDESGTAEWNSAVAAARAERKALATDICMMLLPPQIQRERSSPILLQRAARQVEPEESATLDDLVATVATFGEEGAELAETLGDVRDMPLSRLFFGRSTAQYGQDEAVLTIITMAGLALPDLSIDREFWQLEERMALPMLHLATAFTTRRAYGRAMSDRKLVALDETHFLAGWGSGRALFTRLARDSRKWNIAALAASQNPVDILGLDVQNLVSTVFVGRIAEDPEIAAQALRMLGVQRGIGYENTLAQLSVADTQNDQRLGYREFVMRDVDGRVQKFRADLAYVAGLLEHLDTTADPLGDVGRNSGQEGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVZ4</accession>
    <name>A0A010ZVZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783648_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="13938" checksum="6DC38E65DA8369F6" modified="2014-06-11" version="1">MTSGPDHRGFGAFAPKPGPPTPKPTPPPAPSGPTPANANRANVGPANANPANAGPGSAGPGNASPGNAGPGNAGPGNAGPGNTGPGNTAPADTPTHIDAGVAETQVASVLAELDDLEERPVSEHVAVYEAVHRTLQDTLAAVDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW90</accession>
    <name>A0A010ZW90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853010.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4112"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="35432" checksum="70C89875D9E1842E" modified="2014-06-11" version="1">MTSDTSAAAASAGAPARPPKSGGPGASTRRLQIARLRDLALVPAIIAIAIVGYFVNPVFLSSTNLVNILQTMAEIGLLVLAQTLVLIAGKMDLSLESTFGLAPGLAAWLVVEPGVTHGLGAVPDWAGVPITLAAGAVIGLINGLLIVRFRLHGFVVTLGMLIVLRGLLTGISGGQTFFGLPPSMMYLGSTVWLGVPVSVYVCFALFAVGIAALGYTRVGRSLYAIGGNPDAARAAGIRTDRVLWIVLVLASVLAALGGLMLSGRLASVAAAQGNGAIFTVFAAAVIGGVSLNGGKGTVFGAFTGILLLYVIQNVLTLAGVPAQWIAALNGAIILCALIISRITSGRAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWD0</accession>
    <name>A0A010ZWD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570711.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4155"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="33236" checksum="DE2F3DFC84999D03" modified="2014-06-11" version="1">MTMTQAPEAAKAAPGGRPRPKRRFDVLPYLLVSPVTLFIIALALVPAAFTIIQAFFRVDALDPPTRFDGFGNFTRLFKNDAIVGSIGNTGLYVVIGVTLSTLLGIGMAVLLQRAFRGRSIVIAVLILPWALPGVVEGILWTGIFDPNSGLIASVMRTFGADEGAVLLGQNKFLTIVLIELVQVWQITPLSALLILASLQLIPDELYEAAVIDGASTWRSFWHLTLPMARPGIAVSMVQAVIATLNVFDQPFVLNGAATTGASVTMQTYYVSFQNLDFGQGYALSLLITITTLVISLGVVRAVYRRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWE3</accession>
    <name>A0A010ZWE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853126.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4170"/>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_11"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="22103" checksum="1E4D591B8EF0E158" modified="2014-06-11" version="1">MSWTREQMAARAAAELTDGSYVNLGIGLPTLVPNYVPDDVELVLQSENGILGVGAYPADPDVDPDLINAGKETVTVRRGASFFDSATSFGMIRGGKIDAAILGAMQVSAAGDLANWMIPGKMVKGMGGAMDLVHGAARVIVLMEHVARDGSFKIVDECSLPYTGRRVVHRIITDLAVLDVTPAGLRLMELAPGVTEEEVRSATEPPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXB8</accession>
    <name>A0A010ZXB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851333.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2953"/>
    <dbReference type="HOGENOM" id="CLU_055593_1_1_11"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="35071" checksum="74F4C2BA0B924ED3" modified="2014-06-11" version="1">MKILMFGRGVIAVAYGWALERAGHDVEFYVRPGRAATYGPTVDLELIDTRRRLRGRRVAETWPVRYRESLEPDHDFDLIVVSVQHYSFAEAMSFLAPRVGKATVLVFNNLWVEPSAAVGALPADQVTWGFPGAGGGFGDDGVLRAALLPVVFFGTLGGPPSERAQAVRTAFRRAGFRIQENDDFRGWLTIHFIQNAGLHTQSLKLGSLAELAGKPRHVREAILATRELLPLAEARGVDLRRHRSEVLLFTVPVRLAAPVLSWVFGHVPPMRTVMEAHANPEELRAVCRDTLAEARRLGVPVPRLEAAEPYFAAEQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXQ8</accession>
    <name>A0A010ZXQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570278.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3099"/>
    <dbReference type="HOGENOM" id="CLU_013918_1_0_11"/>
    <dbReference type="OrthoDB" id="859985at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10412">
        <property type="entry name" value="TrwB_AAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrwB_AAD_bind" evidence="1">
        <location>
            <begin position="388"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="774" mass="84985" checksum="7C645CC9A07A921F" modified="2014-06-11" version="1">MIAEPLPAPSQWALDVAEHLWPWIVALVVVGWAARTLRIRQLHRRMTRHAHLVHINPPPEVDPAGASAFWAAMTGILYARLRRRLRDGRAHIGLEYRWSGRKLSLCLWLPATVPTGPVQAAVRGAWPGATCTVTDADPPLPLDAIDAGGALTPALPPWYALKTDHDNDPLRVLLATASGLHAAESICVQVLARPATARQTRRLRAGVEGLQTGRTPRWAFDPAAWLLIVLDVVGELVGPTRRQAAPAPRRPQLDRRTALDKLTEPQWEVALRYGVTHTNPRRVDPDNLRPRLATLAHGVASAFSFWTSRNHPRRMRLRRPATVLAGRSLRSGFLLSTTELATLATLPQDLAVPGLDRARATPRPVPTAVPTGGRDTKVLGRAELGGHAVALPVADARQHVHVLGSTGSGKSTLLLNMILDDIHARRGVVVIDPKGDLVVDLINRIPPQHAKRLVLIDPDQPTGVTLNPLSGGDPDLAVDNVVSIFGRIFAKHWGPRMDDVLRVACLTLLRKNDARLTLIPQLLQDRPFRRTYTADLDDPEGLQGFWDWYETAPLPLRSQVIAPLLSRLRNVLLRPFPRATFGSPRSSFDMRRVLDGGILLARLPKGQVGEDTARLMGSFVVASAWQAATGRARLPETDRRDAFAYIDEAHNFLNLPGSVDDMLAEARGYHLGLVLSHQNLAQLPRETQLAISANARQKVFFNCAPEDARQLARHTQPELEEHDLSHLDAFQAACRLVIGNRETAAFTLRTNPPKAVVGDADEVRRVSAGSVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYQ7</accession>
    <name>A0A010ZYQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3468"/>
    <dbReference type="HOGENOM" id="CLU_069356_28_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="22587" checksum="579728606229F19C" modified="2014-06-11" version="1">MGKLDRMDTQRAPIGRPRGFDATEALEQAMRVFWEHGYEGASLPDLTGAMGISRTSMYAAFGNKEELFRKVLARYTAGPASYGAESLAEPTARRVARVFLDGAVRSSTLPDYPTGCLSLRASLVGSEDGRVIRELLAAWRDETRSHLTERFQRALDEGDLPAGTDPAFLAVYLMTLDNGISVQAAGGADRETLQRIADAALQHWPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ68</accession>
    <name>A0A010ZZ68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852364.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3668"/>
    <dbReference type="HOGENOM" id="CLU_125947_0_0_11"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14934" checksum="5CD03660D6C127D5" modified="2014-06-11" version="1">MTESTNLTTSSTARHSLDLWLTMWNTDGEIARQICADDFRIHFAVTERDGSTPADDIRTAEDFVIYLDWWHEQNPGVVFTRIDDAIDGDHGRLLWDVEADGTLAGGVDVFDFAEDGRVRRVWSVGGQRSMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAV9</accession>
    <name>A0A011AAV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847636.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078241_0_0_11"/>
    <dbReference type="OrthoDB" id="1775418at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="31834" checksum="916FD6F772FE343B" modified="2014-06-11" version="1">MPSDYDFLGHLDPDDPKQASQQIANKLRAAILTGKLQPGERLPSQPDLASRYEVARETVKRALDLLRADHLIVTRQGSGAFVRAQTQRAVELRPHIEAAFEQPHVSIDFAGFSGETLRDAMAEALDKVRAGRHAPESIAVRVLLSDMAAPGPLPASAEGADDPRVRERAARITRRAADGILDQVSELQELGLVKSASADVRLHRAAPLFKLYVLNQHEVFYGFYPVIRRAVSLKGESTEIFDLMGKDVPLFHYVITEDDTSDGAQFVAASRQWFDSVWSTIAYEYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABG1</accession>
    <name>A0A011ABG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847918.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.366"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="28"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="37536" checksum="8957AB5A844704A2" modified="2014-06-11" version="1">MVYEADAARYEQQPYRRVGRSGLKLPEVSLGLWQNFGDVNPLSTQRAILRRAFDLGVTHFDLANNYGPPYGSAEINFGRIFAEDFRPYRDELVISTKAGYDMWPGPYGEWGSRKYVLASLDQSLARMGLDYVDIFYSHRFDPETPLEETMGALHTAVVSGRALYAGISSYSPERTAEAAQILRDLGTPLLIHQPSYSMFNRWIEAGLLDTLGQLGVGCIPFSPLAQGLLTARYLDGIPEDSRVAREGSATSSMLTDDVLSRIRSLNEIAAGRGQTLAQLALAWGLRDQRISSVLIGASSVAQLEDSLAATKNTTFSDAELAEIDKHAVESGIDLWKRSSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACC8</accession>
    <name>A0A011ACC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848462.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.721"/>
    <dbReference type="HOGENOM" id="CLU_721265_0_0_11"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459430" evidence="4">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="5">
        <location>
            <begin position="55"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="37298" checksum="2B5E0B143E58C8BC" modified="2014-06-11" version="1">MRLNTRAVRVAAAAACIAVSLAACTSPGDDTAETSSSSSAESSAAGPDVNGDGKVIVGVLSPGDLNDNGYYESFVAKAEEFTKSKGWQLIKVGSVNPADALNQARNLCRQKVDLVALGAAELKDAIPASEESVCAKSSWYVPSSADIKQTPKITISRDFINEVVYATGYANGLLMKEKNIKKAGYVTGPEADFSVQAAKAFKAGIKEVVPDATLVTTYTGDFNDSGKAKEAAQAQVSQGVGALYPYLGGATDEVAKFGNTKNLILSTPGTDRCASTSPKFQVSSIFDPGEYFAAALQKFSDGQLKMGVAREWHIGKDPVPTVKICGGTAAQNTALETFIKNIGDGKVDVDAQVAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACS8</accession>
    <name>A0A011ACS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2355034_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458367" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="96" mass="9902" checksum="35777E895C78E87C" modified="2014-06-11" version="1">MRATFRLLLAVGLTGAALTIPAQAATADPCGASSYKSGSTQYVAYRNCGESVSRRMRGVIDGSRGACLQVPGATSGVLHKKNIGSASLRPWSLEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD68</accession>
    <name>A0A011AD68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">secA</name>
        <name evidence="20" type="ORF">CryarDRAFT_1056</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569773.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1037"/>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_11"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="12"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="98"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="425"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="893"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EXG80001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="950" mass="105157" checksum="F18EA9A7BADE6C25" modified="2014-06-11" version="1">MAVGHLRELTEPVIFEKILRAGEGRIIRRLKAIADTVNSIEDEYTDLTDAELREQTDQFKERYADGQSLDDLLPEAFAVAREGARRVLGQRHYDVQLMGGAALHLGNIAEMKTGEGKTLTCVLPAYLNALAGNGVHVVTVNDYLAQRDAEWMGRVHRFLGLEVGTILPNAMPGAHKAAYECDITYGTNNEFGFDYLRDNMAGSHAELVQRGHFFAVVDEVDSILIDEARTPLIISGPAEQSARWYTEFARIVPRLRRDRDYEVDEGKRTVGITEDGVEKVEDQLGIDNLYEAVNTPLIGYLNNALKAKELFKKDKDYIVVDGEVLIVDEFTGRVLHGRRYSEGMHQAIEAKEGVNIKDENQTLATITLQNYFRLYDKLGGMTGTAMTEAAEFQKTYNVGVVPIPTHRDMVRKDRPDVVYKTELAKFEAVVEDIAERHVIGQPILVGTTSVEKSELLSTMLGRRGIRHEVLNAKNHAREAEIIAQAGRESAVTVATNMAGRGTDIMLGGNAEYLAASELRNAGHTPEDEDWESLLAETAERVKDQVEEEAEKVTDAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRRFNSGAVEAIMDRLNIPDDVPIESKMVSRQIQSAQTQIEQQNAEARKNVLKYDEVLNKQRQVIYAERKQVLDGADLQEQMQHMLDDIVEAYVGVATGDGYAEDWDLEELFKSLNLLYPVSFTLEELEEEVGGREAIDAELLIARLTEDAQTAYEKREKELGSELMRDAERQIVLAVLDRKWREHLYEMDYLQEGIGLRAYAQRDPLVEYTREGFDLFSGMMDGIKEESIRLLFHAEIQTEEAPAPASAPAADDSPTIEAPTLQHAEVQGLIRPRASNQPLQYSAPAIDGEAGTGGGVAVATDSPLGAGAGGRKAATPGQKVGAGPSRNAPCPCGSGKKYKRCHGAPGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADA3</accession>
    <name>A0A011ADA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848801.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2272689_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="10502" checksum="1DC038BF67E73FDA" modified="2014-06-11" version="1">MKTALLLLLAILGAGGVAAVSLFLITRATVRLAVAGGAFLLGAACFVRLALEGEPAPTYVGMLAQLGLAAALVVALVRYGHALDGRDQAPMPGLRDREEAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFU8</accession>
    <name>A0A011AFU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850022.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2272690_0_0_11"/>
    <dbReference type="OrthoDB" id="1961917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="10968" checksum="4B320144F290C8FD" modified="2014-06-11" version="1">MRILQLAFGNWFSRAYLIGVAVVAAVVTFSLATWDQPDANLAGVWLVFVTMPFSLPLLAITPDSALGPVVFYAVCAVAAVANAAFIGGMVALYRRSRRRPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGC4</accession>
    <name>A0A011AGC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic glycine betaine/choline-binding (Lipo)protein of an ABC-type transport system (Osmoprotectant binding protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850232.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2137"/>
    <dbReference type="HOGENOM" id="CLU_038355_1_2_11"/>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459481" evidence="2">
        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="43"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="32310" checksum="18EDB0420E9316F1" modified="2014-06-11" version="1">MRKQVRMLFAVGSAAALLALTACGGGDSDSGDDPLNQPASSSEVVVGSANFPENVLLGEIYAQALEAKDVKVKRQLNIGAREVIYSQIEKGTLTVLPEYNGALLAYLDKAATATTSEEVDAALKTKLPEGLELLNPAEAEDKDSVAVTKETADKYKLKSLEDLAPVSKQLVIGGPPEFKTRAQGIVGLKDKYGVEFKEFKSLDVAGPITVSALKKGDVQAANLFTTDPAVPSNGFVVLDDPKGLFSAQNVTPLVYKKGVDDTAKSALNAVSAKLDTTTLAQLVKEVVADKKDADVVAKEWLTSAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGZ8</accession>
    <name>A0A011AGZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570044.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313701_0_0_11"/>
    <dbReference type="OrthoDB" id="1719710at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="22975" checksum="06FBF3DBF477AB23" modified="2014-06-11" version="1">MSDAYTVFWPSGRCQAAEPRAEAGTSLEILFGGRHQSLPSFARAGVAAGDVLYPVTVSAKRLFVLGKMTVERLVTADVFALSDAFPQWRFLIDSCMSEAVLGCEGTPLRLDAPMAVEALRRLTYRSTRGSRTLRHLGPDGELLRTNEVQGIYRVDPTNVADLDAVLVQPPSDTRCVRSGTNKRQAKADADRLFWHEFSRPSAATRPDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH99</accession>
    <name>A0A011AH99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850694.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_4_0_11"/>
    <dbReference type="OrthoDB" id="1497065at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="42654" checksum="BCCD63D5B2819D98" modified="2014-06-11" version="1">MIEIVRLTPEDTALTKAGSQLLRTAFGPWPPRAAADEDSDRYRRSTENNVVFAAVEGRDLLGVTSIRPDGQWFAGRELPMGGISAVAVAAHARRRGVARKLLTRAIEQMHGDGRPVSTLYPSIPPAYRSFGWEVAGQLAVIDLPTAVLSAAGLAGPAGVKPSTDVTLRALDRSDPADADLQAVHALYTAAARPAVGPLTRTGPHFRLAKLAELDGVVIASVDGTDAGYASWSRAAASDGSTRLEVHDLIADRQDVRDALLTVAGSWQTSIRNTRVRLADPVLGGVGLPRGGHTLHEPWMLRLIDVADAVAGRGFGPLGGEVDLEITDPQAPWNDGRWTLSVAEGRGTLTPGGTGAVKLGPRGLAAVFTGYAGAAALRSANLADGDETAVARLAALFAGPAPWMLDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHM9</accession>
    <name>A0A011AHM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493851_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19113" checksum="F58E0D64D84EF67C" modified="2014-06-11" version="1">MAGGAGRARDLAPAVVPATVRDVDFRNGDWRVPLRVGEDGSFSVTPLVAEQLVAHFAEGTAVAGANRLSIDTHRFPVRYLQPTPKQVGAADGPVPEAAIVVVELRDAEGVAYVVLGFTGRPGPDFPGPAFLVLLSLDPAGPPEVTTDRDVVSITTPTGREVQRFTRSVVDGTDQGFTRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHR9</accession>
    <name>A0A011AHR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570114.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2644"/>
    <dbReference type="HOGENOM" id="CLU_352590_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="457"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="797" mass="82698" checksum="C21AE5F874129EFA" modified="2014-06-11" version="1">MRQARPRLAVDFGTSTTIAMLRWPDGRVRPLLFDGSPILPSAVLADPDDVLVGADAQYAARSRPERFEPNPKLHVDEGRVLLGPREVPVVELIAAVLRRVLTEAVRTAGEPPAEVLLTHPAAWGPARRAVLRAAATRAGIGSPVLVAEPVAAARAFAVHAAALPPGGIAVVYDLGAGTFDVSVVRREWDGYGVLATDGLPDTGGLDVDAAIVAHLRAAHPDPGSWARLTTPSTADDRRAHRQLWDDVKRAKEMLSRVASTQIVLPLIGVEVPLGREELDALAAPLIARTVATVGATLRAAGAGAPDAVYLVGGGSRFPLVATALHRALGLAPTTVEQPELVVAEGALLLTPAADAPPPGTHEPGAPDHGAGVGGAPEHGARDRGAPDHGAPDHGARGGRPDGGSGSPRRSRRALVGTVTGAIVLVAALVVAVANGTGRFDDDPSTRTTPAAACNRVIAVLGAETGQSAGVTAQIRDAARLAADQRTRARPACPVRLEVLDTQGDPLTAAALARTLTDRAEVVGVVGPLFDGEVAEAGRVLDEAGLPFLTPMATSDALSRQGWRTFHRMVPGERAEARAIAAHLRDTGARSVLLVSDGRPASTSEITTIRTELRGSLTVIDAPILEQDPAAVVTAARNATPDTVVFAGGYPVGGPLLRALREAGVTARFVGNAGSDNSGFITGAGAPYAQGAVVTCPCFPQESAPPDFRRSYRSAFAVEPGVLSPAGYDATRILIAGLDAGAGDRTAMRTFVDDYRGEGTFGRLRFQDDGELHPDAARIWFYQVDGGVFRSLGSRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHY2</accession>
    <name>A0A011AHY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851021.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189201_0_0_11"/>
    <dbReference type="OrthoDB" id="1525475at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="21892" checksum="52E394709846D0A4" modified="2014-06-11" version="1">MRIYAVTPLHVGAQELARRQERYDWIAPDGVVVDLHDLPFGAPMSLETPADMRSSERYVVEALAGAPAGYDAVMPDCVLDPGVAAMQADPAFGIVIGVLRVTVAHAAAVGETVAAVVRNTAIADEMRAVVDGYGWGAVVTPVRTLDLDFAAVADGDRWRERLAGAAAELAGSGAAALINGCSAVGLGAAEGAAPIPVVDPVIRTLRLVAAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJF2</accession>
    <name>A0A011AJF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">CryarDRAFT_3288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851743.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3246"/>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_11"/>
    <dbReference type="OrthoDB" id="955232at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="5"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="37777" checksum="29CC78C56F3E8B2B" modified="2014-06-11" version="1">MTVALITGITGQDGSYLAELLLRKGYEVHGLKRRSSSFNTDRIDRFDSDLWDPDAGFFQHYADLADGASLAHLLCRIQPDEIYHLGAQSHVRVSFDLPGYTTDITGMGTVRLLEAIRVAGLDCRFYQASSSEMFGATPPPQSETAPFHPRSPYGCAKVLGYWATVNHREAWGLKATNGILFNHESPRRGETFVTRKITRAVARIEAGLQDVLYLGNLDAIRDWGYAPEYVEAMWMMVQHPEPDDFVIATGEAHSVREFVVAAFAQAGLDWERYVRIDPSYYRPSEVDVLIGDASKAERVLGWTPKTRFSDLVRIMVDADRQLLDDERSGRLVRVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJM4</accession>
    <name>A0A011AJM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851851.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3316"/>
    <dbReference type="HOGENOM" id="CLU_017028_9_0_11"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458558" evidence="2">
        <location>
            <begin position="21"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="88"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="564" mass="59821" checksum="389B6A04F614103B" modified="2014-06-11" version="1">MRKSLAVALALTLGSATLAACDNDSGGSSTAFDPENCRGGTLVVLNQGGISQLDPARLYTSGGGNVPSLLFRTLTTRNRQPGQAGTKPAPDLATDLGTSTDGAKSWTYHLRDDIYFEDGTPITAADVKYGIERSFAPELPGGAPYLRDWLIGAADYQGPYKQPAGLKSIETPDDKTIVFRLRKPEGDFPYLATATQFAPVPKAKDNGVDYGNKPVSSGPYKIASYDKGKHLALVRNTAWDQKSDELRYACPDQIDVTAGLNSAVINQRIATGSGKDRYAVTTDGIIGPDQLAQLGTGSELDKRVARGEFPSTTYLAFDTTKTPFDDVRVREAVSHAVNRTSVVNALGGTASAGPSTTFLPPQEALGYQAYDYFPAGKSGDPAAAKKRLAEAGYPNGLTVDFAYENDDSNGLGPKVAAAVQEALKQAGITVRPKAIDSASYREVVGKPATQPALSLNSWGADWPSGGPFLIPIFDGRQIIKGGGNFNLAQYDDDAVNAEIDAINALTDPAAAAKRWGALDAKLGKLALYVPLTHEKDTYLFGKGVKNAVPDGWRGQYDLARVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJY7</accession>
    <name>A0A011AJY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570411.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3400"/>
    <dbReference type="HOGENOM" id="CLU_000445_100_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="31452" checksum="A7DBE56C1A7243AD" modified="2014-06-11" version="1">MSLEALTAGIERHAQTRGVSTAVPGLVLAREDREVQDIDLAYRPMLCFVAQGAKRTVAGRRATRVARGEVFLSLLDVPVVATYEVPFRSATLDIDDEKLAQVISQRHTVSPVPVQRPTEGFAVAAMDQGLVGAVDRWVGLLDEPHHRDVLAPLLEYEILHRALSSPLGPALRAAVSTGPVRAIREAAAELRDHYARTIPIHELARAAGMSPATFYRHFRAVTGLSPNQLQRITRLQNSRRLLAAGKPVTTTAQAVGYASASQFSRDYRLQYGRSPAADARIMRADPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK43</accession>
    <name>A0A011AK43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863879.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3472"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="25269" checksum="C13F78FD964F5EA6" modified="2014-06-11" version="1">MNDLAGMTALVTGSTTGIGRATAVALAARGASVVVTGRNAQRGAEVVEKIRADGGAARFVAADLTRQEDIARLAQDAGAVDVLVNNAAVASFGPSASITIEQYDAMLEGNLRAVYLLTAALAPRMAERGSGSVINVSSGSAQVGDDNNAVYAATKGAVNALTRAWAAEYGPAGVRVNAVAPGPVYTGVPVEYLDRYIPLIPLRRVAQPEDVAEVIAFLAGPGGSYVNGATIPVDGGLTAVEPPKQPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALL7</accession>
    <name>A0A011ALL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3986"/>
    <dbReference type="HOGENOM" id="CLU_107911_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="22436" checksum="1CC09B9E05576A2A" modified="2014-06-11" version="1">MQTSRRAEYAQRTREAILDAARTLFVEKGYFGTKVDDIARAARVAPATVYAVGGGKHGLLRTLIESGTNSEDVPRILARITEAGDPGDLIRFVVRATREQFAQWSDLMRQVAAAAPQEPTVREIQEIAHAGMRHGLSVTAGRLATLGALRADVDVAKATDLLWLHLCNSAYFIRTDDLGWSLDESEAWLTEALSRALLPPADIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALS2</accession>
    <name>A0A011ALS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852919.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4062"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="482" mass="49730" checksum="53E15AEFA5FE8E5B" modified="2014-06-11" version="1">MTLAADAPRTAPSTEQRLSPADRNLIGLLVISTFVVIFNETVMSLALPRLMSDLNVSAATGQWLTTGFLLTMAVVIPATGFVMERFSVRQVFVAAMGLFSTGTLIAAAAPGFGVLLLGRVVQAGGTGVMIPLLMTTAMSLVSPGSRGRIMGVISIVISVAPAIGPTVSGLVLSRLSWRWLFLVVLPIALLSLALGAWKVRNVTTPRRAHLDVLSLVLSAAGFGGLIYGLAGLGESGGHAPVAPWIPVVVGLVALVLFVRRQRALQRGRGPLMDLRVFAQRSFTVSVLVMIAGFMSLFGALILLPIYLQSVHGLSTLAAGLLVLPGGLAMGTLSPLVGRLYDRFGPQPLVLPGTVVLSAALWLLATVGPETSTALVVLFHVMVMSALALMLTPLMTSALGSLPADLYGHGSAVISTLQQVAGAAGTALFVTVLSRTTAAGLAGGADTVTATADGVQAAFVWGGVISLVAVVAALWVRRTPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFQ8</accession>
    <name>A0A010YFQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03943 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847485.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079638_0_0_11"/>
    <dbReference type="OrthoDB" id="1936285at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="28667" checksum="60039CA3159C17DD" modified="2014-06-11" version="1">MRREVQAVVFILLGAVLLKLVISGEYLNYVQSLLKFPLVATGVVLIAFGVLGFARDWRGRGALERSRERAADARVRTHGPGAQPDDEHEPDVDEHAHDHVGDGHGVGWLWILPVFVLVLVPPPALGSFAAERGAATVPKPPKSVEFAALKGSNPVPLEVHDYAQRAVWDNGRTLTGRTIELSGFMTPHSGGSWYLTRMKVNCCAADARPYQVEIVDSPVPAVRDEWVKVTGTWVPSTAKDPFDAVALLKATTVNGIPTPAQPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG84</accession>
    <name>A0A010YG84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxyanion-translocating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.258"/>
    <dbReference type="HOGENOM" id="CLU_044079_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="370" mass="39540" checksum="693D8FB9BCFD9AD3" modified="2014-06-11" version="1">MTVFDVETLLTDPATRIIVCCGSGGVGKTTTAAALGLSAAEAGRRTVVLTIDPARRLAQSMGLSELDNVPRRVKNAGDNGGELHAMMLDMKRTFDEVVLAHTDPDRAEEIFANPFYQAMSSSFSGTQEYMAMEKLSQLRAADEWDLIIVDTPPSRSALDFLDAPQNLARFLDGRLLKLLLAPAKTGGRGVLKVMSGTFSLFSRVITKVLGTQLLDDVSTFVSALDSMFGGFRERAQRTYDLLKTPGTAFVVVAAPEPDAVREASYFADRLTGEGMPLAGLVLNRVHATEVPNLSAAASLAAAEKLGDSVTAEVLRMHAGLSRLVERERRIAAGFTTAHPDVPVVEVPAEAEDVHDLDGLRRVGAALTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGN5</accession>
    <name>A0A010YGN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.444"/>
    <dbReference type="HOGENOM" id="CLU_105860_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="17134" checksum="EEEE4A398329417F" modified="2014-06-11" version="1">MVAVHDYELALTWTGNQGTGTSTYRAYNRSHEIVADGRPPLYGSSDPAFRGETDRWNPELLLVAALSACHLMSYLHVCVESGVVVVDYTDAPTGSMTQTPGGGGRFTEVTLRPQVTLASASASKLELATRLHRDASARCFIASSVNFPVHHEPTVVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHF1</accession>
    <name>A0A010YHF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD, TfdA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848468.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.731"/>
    <dbReference type="HOGENOM" id="CLU_041041_2_0_11"/>
    <dbReference type="OrthoDB" id="1742732at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="65"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="361" mass="40734" checksum="52C718F5826ADA9E" modified="2014-06-11" version="1">MTVTTDLSPVTGPAAWRGDQLQDNKTWIYHLSDAEIAELEAVGRKFVEDDPDLRVVTKADYPLPVCEEAIKTWASDMDRGRGFVLIRGLKTELYSDALSGAIFYLTGLHLGVPMKQNEMADLIDHVIATSTKTMDDPSALSSRVADKLVFHSDSSDAVALFCLRPAKEGGASSLVSGAQIYNEILSRRPDLAPLLHEPFYFDWYKQDHDAPEKTYTSPIVSIKDGVFSMYAGSTYIFTAQDYPEVPRLTEQQIEVIRLFDEITYEPGMALDMDFQPGDIQWVSNYAALHSRTAFTDWPQYGRKRHLLRLWLKRDSDRPLVDKFGKHVVKAREEDREDTSGVEDVGQFSVKTAVVPRMDWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHI5</accession>
    <name>A0A010YHI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase and permease component of ABC-type transporter involved in cytochrome bd biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298078_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="22717" checksum="D10C0B6ABCC90D28" modified="2014-06-11" version="1">MEFEPSEPGPRSLSVDLSERTLRLENVRDGVSFEVRPRRVTALFGSDDASNLLTVALGLVRPEQGRVTVDGVDLDDLDPSAWWSEVAWVPRRPALVAGSIAENIRMGWSATDAEVADAARAAGLDGTLDAVVGEDTRADDRRQRIGLARVFLRNSAVVLLDEPTAMLDADGEEALAVLRRLVAGRTVLLAVHRPALLAIADVVIAVPALVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJB5</accession>
    <name>A0A010YJB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569850.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1345"/>
    <dbReference type="HOGENOM" id="CLU_911260_0_0_11"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="29913" checksum="87C7A288AB7031AD" modified="2014-06-11" version="1">MNETITTIVGNVVDAPTKRTLESGVSVTSFRVASTARRFDRVTNRWTDGDSLFLKVTCWRALSENTSACVVKGDPVIVTGRLFSRTYEVVDGKRASYEIEATAIGFDLNRGRGDFKRVSATRAVTVDDVGPDRMPTGSSIDAHISSGAVTADGAASEGSPDDAFDEPDVDAGEAFENASPVRPESSVSGGDESGGAETGSSGGAAETGSSGGAAETGSSGGAAETGSSGGAAETGSSGGAAETGSSGGAAETGSSGGAGSSGGAAGAPAEESGGARKEKSAASGAAPVPTPRPPARRRGAAPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJU6</accession>
    <name>A0A010YJU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monoamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849457.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1572"/>
    <dbReference type="HOGENOM" id="CLU_004498_0_4_11"/>
    <dbReference type="OrthoDB" id="1442136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="454" mass="47829" checksum="8D5D92741EFAD841" modified="2014-06-11" version="1">MTDVDVVVVGAGLSGLTAARNLQQRGLSVRVFEALDRVGGRVRSATVAGAVVDLGGTFVGPGQDRILALADEVGVGRHPTHDSGDNLLLWRKDRRRYRGLVPPLGAAGLVDLVRVRSALERLSRTIPVGRPGDAPGAATLDAQTLGSWLAAKHACRGTHDLMAVVSRTSWGCEPSELSLLHALHYVAQAGGLDALLGTRGGAVERHFVEGAHAVAARVADGLGPGTVRLGTPVLRIDRAGDGVTVHTDDGPTTARRVIVAVPPALRRRIRFAPELPSAHRRLAQRWSPGILSKIYAVYDTPFWRGGGLSGMSISDEGPVFITFDTSPRDASRGVLLGFVGGDYARDWDAVGAAERRIRALSALADLFGDRALRPLGYTDHRWGEEDWLGGGPTAAPGPGASAGLHTRLTEPVGPIHWAGTETATRWAGHLDGAVSAGERAAREVTVALTLEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM79</accession>
    <name>A0A010YM79_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">CryarDRAFT_2415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725701.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2378"/>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_11"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="661" mass="67791" checksum="81F524B44B77CB8E" modified="2014-06-11" version="1">MAPPRGQLRAGRYLAVLAVIVIALYALVFLQGKGSVSDKLTPRLGLDLQGGTTVTLHAAQENGKAPDAEQLEQARQIIENRVNGTGVAEAEVVTEGDSNIVINAPGENNDAIKQVGEPAQLRFRAVLESAQDIDAIKATASLAATPAPSTSGTATPNPSGSANPSGSASPSGSASPPAQTNASPSTSGGGGGGGSVPQAAPAAVPAAEDTPSPTPSTAGSASPAPSTSASPSGSASPTPAATPTSASQAALQKSALAKFPKDAATYVQQGTAQDFAGAATNPQLAAVFEPGAAKLTEAEVAALPVDWQYKVPWITCKMLDERPAGSIDPINQQVVACQDTTKYKLEKAGVVGTDINTASFTFNQQQGGWVVNLKFTSNGQDKWTALTKATLQKQVAVVLDNEVISAPTTNEVITGDTQISGQFTKADAQDLAAKLKFGALPLSFTVETAETISPTLGIEQLEAGLLAGGIGLALVVVYSLLYYRALGLVTIASLAMSGAIIYAAIILLGRQIGLTLTLAGVAGFIVAVGITADSFVVFFERLKDEVRDGRSVRSAVPRAWVRARRTILSADAVSFLAAAVLYILAVGAVKGFAFTLGLSTLVDVIIVFLFTHPLVALLSRSRRFTSPRFSGLGTLRKASDAPPVGAAGRRATARRVSPKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM88</accession>
    <name>A0A010YM88_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">CryarDRAFT_2431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2394"/>
    <dbReference type="HOGENOM" id="CLU_025574_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="392" mass="42445" checksum="122AEA71B6CBD661" modified="2014-06-11" version="1">MNDLDLVPFTDESGGYGPGNPGRHRRKKERSGGRTLVALAVVVAVLGGLAFGGWYGVTKVRDFFTADDYPGPGNGSVMIVINQGDNVTDIGNTLFENDVVASAKAFVNAAADNPDSTSRLQPGNFKLKKQMKAEDALLVLMDRNNRESGPRVTIPEGLAVVEILPLLAKATDIPLTDFQEAVKDPAALGVPEWGGPSPDKLVLEGFLFPSTYELTGKETAQSLLQEMVKLAVQAATKDELATKAKELGVTEWEMLTIASLIEQEGIDDDFGKVSRVIYNRLSQETGALTYLQFDSTTQYWLIITGKGRKKIVTDAELKDPDNNYSTHVDRVQGLPPTPIGNPGDAALKAAANPEPGDWTYFVVTSKDGHSSFTSNYNQHLANIEKCRQVGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMF7</accession>
    <name>A0A010YMF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2485"/>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="58"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="25566" checksum="8FF5ED6580A57DDC" modified="2014-06-11" version="1">MLASAGIGSRRACEELIEQGRVSVDGKVVQVQGKRVDPLTAVIHVDGQRVIVDDRMVYMAFNKPTGVITAMSDDKGRLNIGDYVQDRETRVFHVGRLDTESEGLLLLTNDGALAHRLTHPSYGVLKTYLAEVPGPMNSDVKKRLLEGVELEDGFVKVDNFRVVDNLPGKLLVEVVIHEGRKHVVRRLLEEVGHPVSRLVRTAIGPVQLAAIKPGKARHLSQAEIGQLHSQVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPA4</accession>
    <name>A0A010YPA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA/RNA helicase, superfamily II, SNF2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851531.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3111"/>
    <dbReference type="HOGENOM" id="CLU_307750_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="126"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="437"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="967" mass="106328" checksum="0B05C9AB7C39E523" modified="2014-06-11" version="1">MTAPTDAEPSSFPPGAQVEIRDEIWLVRKVTVTEHDGAMLEVTGVSPFVRDVDAVFYASLDTITPLDPRKTILVPDDSPYHRRARLYLEAVIRKSFLPQTETGLALAGAFLADYQVHQVRPAQLALSMRNPQPRLLIADVVGLGKTLEIGILLAELIRRGRGERILVVTPAPVLEQFQRELWTRFGIPLVRLDSTGIQRVQQEIPLGRNPFAYFKRVIVSVDTLKNSKLYGHHLEHTDWDAVVIDESHNLINRGSHRNELAQTLAPRTDALILASATPHNGDGRSFAELIRLLDPAAIADPAKYDVSDLEHLYLRRSKNTPEVRDALRGAWADRGPSLPVRAAATPAEEAVFDALAAEWLPADGKPSVSAARLFPYTLFKAFLSSHKALLETVGQREQTLKDRTDAEAERTALAELRQVATKIGDGDSAKLAALVAELRDLGVRPGSDTRVVVFSERTATLNWLADVVPLALGFPADSAEDEKRPWLKYRGVVEVMHGDVTNDQEQMKVVERFGLRDAPVRLLFTGDVASEGVNLHQQCHLLVHYDLPWSLIRIEQRNGRIDRYGQKYPPQFRAMILTSTVQWRPRAAPMLDQPEPGYRPFDDRLVGEILLAREAEAHRIEGSADAVSGLYRPQDEEDRLTRDLIAGQTVPESLAASAQTAGGFLAGLLGRQAGATPPNSEVPRAVVPALFNHTEDYVHTALRQVFHDAPEGALSLRYDEDGAISLTPPPDLVYRLRALPASYLSEQRILGTADEPGRMSVTFSRKLAGHRLDAARESSDTMWPSVVYLTDIHPVLDWLTDKVLIEFGRHQAPVLGAAVSTPTFLVQGIYSNALGRPTVVEWMAVDGLPGTPRVTSMTEALAAAGVGADMPGRRTPHDLPGLQSLVPSAIDAATAHLTARRAAYDAEIDTALAPYRRRLDAWRQTAPPGTTKSRHAEAVNRRGDLVRGLETVGAPMLRLLAVLEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ34</accession>
    <name>A0A010YQ34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851967.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3399"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_11"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="28836" checksum="468B5E54EC60852A" modified="2014-06-11" version="1">MTVWLITGASRGFGRLLTGAALTGGDKVVAGARDARTVTKAFPEAGNDLLAVDLDVTDAGQVAAAVDAAKDRFGRIDVLVNNAGYGLFGSVEETPDVEVRQLFDTNVFGLLNVTRAVLPVLRRQRSGHVITMSSSAGFASSAGRGMYSASKAAVEAVSEALQEELRPLGIHVTIVEPGSFRTDFLSANSARQVAVGIDDYTDTVGSLLAAIEANDGKQPGDPAAAATAIRRLVAGANPPLRLQLGSDSLRLVEGKLDLVRQESDRWRALALSTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQP4</accession>
    <name>A0A010YQP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852395.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3681"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="23791" checksum="CA7A74E0913BECC6" modified="2014-06-11" version="1">MLELTDVEAGYGRTRVLHGVTVPVGRVVAVLGHNGAGKTTLLRLAIGLIKPSSGRVVFDGEDVTSLAPNQRIARGMAYVPQGQQAFSQLTTLENLQLVADGRRGGKALVDAQLARFPALEQFAARKAGLLSGGQRQQLAIARALITSPKLLILDEPTEGIQPTIVAEIEQTIVQLAAEGINVLLVEQHIGFALEAAERYVVLASGRVTQTGDGGAAATSTVRAAMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRM1</accession>
    <name>A0A010YRM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852860.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4029"/>
    <dbReference type="HOGENOM" id="CLU_105030_2_0_11"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="19750" checksum="BC8CA5B3FD5AF5A5" modified="2014-06-11" version="1">MSDATLFLMVGLPAAGKTTRARELAAAHRALRLTPDHWMIPLFGDSMADGKRWVLEGRLVSVALQALRLGTSVVLDYGLWGRDERSALRWLARWCSATCQVVYLPVEKEMQLARIAARRETAAHETFPMTEADLDGWRPQFEVPDAAELGGGELPEPPPGWGNWGEWAADHWPSCLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVD5</accession>
    <name>A0A010YVD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.128"/>
    <dbReference type="HOGENOM" id="CLU_060077_4_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14285" checksum="B78F5D909EB50CDE" modified="2014-06-11" version="1">MRIGELAERVGTSTRALRHYESLGLLSARRTSNGYREYDDSDVRVVREIRTLVGIGFALEETRPFVECLRAGYESGDSCPASVAVYRRKIAEIDDCVASLAAVRARLSSAMSGGGSLADAPEPLCAFSPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVZ0</accession>
    <name>A0A010YVZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase/secretion neighborhood TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104210_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="11405" checksum="0D4228632634C766" modified="2014-06-11" version="1">MTDSRGSASVLALGVGLALLLVGLGFQSVGAAAVARHRAGLAADLAALSGALHVAEGASAACVRAAALAAENGATLTECTTTGTHVIVTTAVPPTGPAALIGRATATAHAGPVIPPVRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW75</accession>
    <name>A0A010YW75_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="12" type="ORF">CryarDRAFT_0433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.417"/>
    <dbReference type="HOGENOM" id="CLU_787128_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="39023" checksum="8BA02B21BBE803DB" modified="2014-06-11" version="1">MVGTEREEQLRQTLARIAPGTSLRDGLDRILRGSTGALIVFGHDKTVDAISTGGFPLDVEFTPTGLRELAKMDGALVLSNDGSRIVRAAVHLMPDASIPAIESGTRHRTAERVSRQTGFPVISVSQSMRIIGLYVGGLRYVLDETSSILSKANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAMSVTQRLEMVRRISDEIAGYVIELGTDGRLLKLQLDELMAGVDADRELVIRDYLPSGRRNRSVEEVLDDLDRLSATELLDLTLVARGVGYPATADALEGAVSPRGYRLLAKVPRLPGAVIDRLVEHFGGLQKLLGATVDDLRAVEGVGDARARSVREGLSRLAESSILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWR3</accession>
    <name>A0A010YWR3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848346.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.625"/>
    <dbReference type="HOGENOM" id="CLU_021523_0_0_11"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="751" mass="82357" checksum="4BD502D8BCCDEA67" modified="2014-06-11" version="1">MARLSTILDQIDAGSMLLPEFQRGYVWNRDQVRGFMRSLYLGYPVGSLLVWETDTTDKAVRGGPGGGVRQLLLDGQQRVTSLYGVTRGRPPAFFEGDPAAFTGLRFHVAEESFEFYAPVKMKDDPLWIDVTELFVHGAERQIERLASDAKNWQYVGKLMKLQNLLEKDFHAEQITGPDKTTDVVVEIFNRVNSGGTKLSKGDLALAKICAEWSGARPTMRSYLRRWADEGYDFSLDWLLRNVNAVATGRAPFSALDAVSADEFEQALTDAADHINLTLDEIASRLGLDHARVLPGRPAIAVLSRLLSENGGEFTDPFERDKALYWYVHAALSGRFAGSTETYLNQDLATVSGPRGVDDLIGRLRRWRRSLVVKADDLQGAGKGARYYPLVYLVSRVLGARDFATGETVGDFQVQPLFGKGLLSRAGYRPAEINAIANYVLVTPESAAEVARRRPEDYLGGAEEMFPGLLASQCLPDDPALWSVDRYRDFLAARRKLLAAAANEFLDGLHAGARVDAPRLPRVAVRSGGDDEIDIRAEEVSALVEELIRLGLAAPERDAEIPDPETGRALSVAEAVWPDGLQPGQGAPVVLELDPDEADLPRMAELGYEVFTSVEALRGYALRRRREAGGEPPPEAPVSPAVGRVPVAAAATATDPEQELHQAMAAIYQKARDETGYNATYLLSMLAEDGAVETARRLLASATVSTGFTALWNKGRLDLTVEALVLDPRFAGLFTTDELDIARTRLAQFDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWS8</accession>
    <name>A0A010YWS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848369.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.640"/>
    <dbReference type="HOGENOM" id="CLU_013420_0_0_11"/>
    <dbReference type="OrthoDB" id="1388804at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="477"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="777" mass="80946" checksum="16486E2ADD1ABA1B" modified="2014-06-11" version="1">MDHLVAHVRGLDRAALAELIAARPDAVSWPEPRSLTDFAERLGAVHSVQRALARVDRAGLQVAEAMAALGGAAPEPRLAELLDVDDAELFRRTLASLAALALVVRADDGSLVLVAPLRLLAEPLGLGVRLSGVLPLLTVDRLRAIAELWVPSPARRRTELVDQVLDAVADPARVRDVVDGLPPDARELLRDLAWNGPRAAASSDRSYHWCVERGLLTQISWDYVELPGEIGLALRGPDYRAPFSVPPPSPVSGSIGEDDLVAAGTAATTQVLADTERLLELCERTPLATTKSGRVTVREAKRAEKAIGAGVGTLLSVASAAGLLGSADGAVTVTERADAWRDAEPAVRLATLLSGWWSEPDGAVLRQRFVGYLAELPDGARTDDVDAVAAALSWRHPIAVAPTPVDQETVAARTAAVRAEAERFGVVALGAATPVARALVARPASVAAAPGAPMVAPDALVTAAERVVPAPVTTVTFQSDLSAVVAGVPTAELAGLLDGAADREAAGAASIWRFSAASVRAAFDGGATADALLAELSAVATGELPQALGYLVGDVARRHGHVRVAPAGSVVCADDEALLAELVATKSLRALRLRAVAPTVLLSVADPDETLAALRAAGYAPAGLTEDGVARVERRVHRRANAPRPWSPQPEASDVDPGAIADRLLSAPEAPVRPRSDPWVGLPRTVAEARADLAARHPGVVVDRQADALSAPERALLLDAIETGAPVRIDYVGATGSATSRVIENAELAGDAVIAWCHLRAAERMFILSRIQTVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWZ7</accession>
    <name>A0A010YWZ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848452.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_0_0_11"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="15400" checksum="03787F625779C8C7" modified="2014-06-11" version="1">MNSSYRPNGGDLATAGLSAEAQTFNWLLDSFCTGTAGVVEAVAVSADGLLMAKSATSDHANADRLAAVISGMTSLAAGVADTYSLGGLNKVIVDLTGGYLLATAISRGSVLGVIADRTANLGTVAYEMTLFASRAGAVLTPALIVELKNSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXU1</accession>
    <name>A0A010YXU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848779.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1064"/>
    <dbReference type="HOGENOM" id="CLU_2272688_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="11564" checksum="5BE3662BE0C91890" modified="2014-06-11" version="1">MEIEQASAGEATEYAVVRKYSEAVRSLGEHLGIAPEAAQRALQEGRAADLLRRRRPGLRSVSEGVPETVQSRRRKLDEMQRTWRLEDLQRSARRPRPSPGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXX5</accession>
    <name>A0A010YXX5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848842.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135567_1_2_11"/>
    <dbReference type="OrthoDB" id="2089955at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="6962" checksum="C9F4F5F77DCB007B" modified="2014-06-11" version="1">MSFDDKAENKTQELKGEAKERWGGATGNESLQAEGAADKSESRIKQAGEHIKDAAHSVKDAFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY77</accession>
    <name>A0A010YY77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2583833_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="80" mass="8719" checksum="EA51980B4C673A36" modified="2014-06-11" version="1">MSAARRVNTAERTPAEVEAAEKFIADLIARGEAVEIDHTPADGADTQNDAVEKPLPSGATHEVVRRDGETVVKRRRYSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYL9</accession>
    <name>A0A010YYL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849121.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1342"/>
    <dbReference type="HOGENOM" id="CLU_016513_0_0_11"/>
    <dbReference type="OrthoDB" id="433393at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="9">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="187"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="291"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="553" mass="59549" checksum="B1A733D7928F932B" modified="2014-06-11" version="1">MSEAVTDSSVSTATHGVTNQPPPLVGHDVADDAALLAGVVREGASWFLPELHELGVWASSAEAQTWADEANRYEPVLRTHDRYGHRVDEVEFHPSWHRLMEVSVGAGLGATPWADDRVGAHVARAAGVFVAGQVEAGHLCPLVMTYAAVPALRAAPDLADVYEPLLASRVYDFGLRVPTTKRGLLAGMGMTEKQGGSDVRSNTTVARDAGDGTWRLRGHKWFTSAPMNDVFLVLAQAPGGLSCFLVPRVLPDGTRNTFRIQRLKDKLGNRSNASSEPEFDDTVAWLVGPEGRGVRTIIEMVSLTRLDNVIGSAAGMRAALVQAVHHTRHRAAFGRLLIDQPLMGNVLADLALESEAATTLALRLAGAVDRAQFGNDQEKAFGRLATAIGKYWVCKRQPAFVAEALECLGGNGYVEESGMPRLYREAPLNGIWEGSGNVNALDVLRALGRSPEAFAAYSEEVEGSLGADSRLDAAWTSLQRELADTHEWEYRARRLVERFALVLQGALLVRHAPEDVASAFCGSRLGGESGYAFGTLPRGTAIDTLLDRAAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYW9</accession>
    <name>A0A010YYW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569881.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1464"/>
    <dbReference type="HOGENOM" id="CLU_010363_4_0_11"/>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="546"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="790" mass="79758" checksum="B120F1DCB9E53177" modified="2014-06-11" version="1">MTGHDRRPAAGAVARAPLDLRLAGVALGAWAATWWCLGHGPGAAAVVAGGAALVAIAAGLRARASARRWGGVALGVVGVALGVGMGAVAAAPRLVERDSGALARAVERSGPVGMRLVVRDDPRPAASRRGGAPLWVVAASAEEITADGVRHMTSGRVLVLGEHPDWAGLLPGQRVTVDRGRLLAPHRRDLTAAVLRTAARPWRLGSPPWLQRVAGSLRTGLQEACAPLPGKPGGLLPGLVVGDTSKLDPSVDDAFQQTGMTHLTAVSGANLAILAGLVLAALRGVRAGPGWSAALAALAIAGFVILARPSPSVVRAAAMCGLGLLALALGRPRAAVPALCVSVVFLVLLDPALAAAPGFALSVAATAGLLLVAPAWSGALKRRGVPAVAADALAVPAAAQAACSPLIAAFTGTVSLTAIPANLLAAPAVAPATVLGLLAAVTAPVAMPLATALAWLGQWPAWWLVEVAERGGRVPDGLLPWPGGAAGGWLLAALLVAAAFAARWRLPRRLIAVVGATVVVVALPIRVAAPGWPPPGWVVVGCDVGQGDAVVLRAGAASAVVVDAGPDPAPVDACLRRLGVEHVPILFLSHLHLDHIGGLDGVLRGRSVGAIAIGPYREPPEGAAAVSREARRHGVRIVSLTAGGRLTAGAVGIRVLGPLRVLRGTRSDPNNNSLILRADVRSVSVLLPGDAEHDAERAVLSAGEPLDVDVLKVPHHGSAWSDPAFLDAAHARVALVEVGADNDYGHPAPAVLAHLARQGARVLRTDRSGDLAVVALADGTLSTAVRGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZM7</accession>
    <name>A0A010YZM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="8" type="ORF">CryarDRAFT_1742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1712"/>
    <dbReference type="HOGENOM" id="CLU_083252_2_2_11"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="185" mass="19954" checksum="5896BDC9390C4784" modified="2014-06-11" version="1">MEGGDRIVGTVRSRYRWFLVWAAVVLVVDQATKYWAERTLSDGREIEVIPPLIDFRLVYNPGAAFSIGESMTWVFAIAAAAAVVGILYYARRVTSLGWALALGAVLGGAASHLGDRLFREPGFARGHVVDFIDYNGFFVGNVADIALVLGAIVLALLTFREVPLRADDAPAPADKSGDRSPEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0B2</accession>
    <name>A0A010Z0B2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850014.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1952"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="22687" checksum="575A321631332D49" modified="2014-06-11" version="1">MSPVRVMVVDDHPMWRDAVARDLGDAGFDVVATAGDGAAAVRIAAASRPQVVVMDLQLPELSGVEATARILAADPSCRVLVLSASAERPDVLDAIRAGATGYLVKSAGATELIEAVTRTSRGEAAFTAGLAGLVLGEYRRLAAGPEPADGPALTTRETEVLRLVARGLTAKQVATRLSLSIRTVQNHLQNVMDKLQVHNRAGLVRYAIEAGLDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1I9</accession>
    <name>A0A010Z1I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="69" mass="7933" checksum="4FD623440B4D45C8" modified="2014-06-11" version="1">MVEKLFFRKSTKSNVANCVEVAFSHRGTLLRNSRYPDGLVLELTRREWEDFRAAAASGRFDRPGCDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1P4</accession>
    <name>A0A010Z1P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">CryarDRAFT_2449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570061.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2412"/>
    <dbReference type="HOGENOM" id="CLU_060704_0_0_11"/>
    <dbReference type="OrthoDB" id="1181405at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="29758" checksum="394EF54D82AD68DA" modified="2014-06-11" version="1">MTVNTAAAPQVAPTTDHFGARLARAVADRGPLCVGVDPHPGLLDAWGLTRDVAGVERFARTVVEALADRVAVLKPQSAFFEQYGSRGVAVLEHVIADARAAGALVLNDVKRGDIGSTVEAYAAAYLDPASPLCGDAMTASPYLGFGSLAPLIDTAVANGNGVFVLGLTSNPEGPQVQHAVAADGRTVAQTVLDSVAAANAGCVPEADGAPYGPVGVVVGATVGETGHDLSRVGGPFLAPGLGAQGAGAEDLRAVFGDARRAVLPSVSREVLRAGPKHSALRSAASRAADDFAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1Q8</accession>
    <name>A0A010Z1Q8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisE</name>
        <name evidence="11" type="ORF">CryarDRAFT_2464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850653.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2427"/>
    <dbReference type="HOGENOM" id="CLU_123337_2_1_11"/>
    <dbReference type="OrthoDB" id="2022633at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="87" mass="9386" checksum="4ED15FB53396E4B0" modified="2014-06-11" version="1">MKTFDALFAELSAKVAAGTEGSGTVEAVRAGVHTVGKKVVEEAAEVWMAAEHESSERTAEEISQLLYHLQVLMLARGLSLEDVYAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3U4</accession>
    <name>A0A010Z3U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3155"/>
    <dbReference type="HOGENOM" id="CLU_007383_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="23370" checksum="AA95E254D8678A95" modified="2014-06-11" version="1">MVTAALETGVDTTTGEGVADAVAGADVVIDVTNRAVFDPEVVMDFFTTSTHTLLDAERQAGVRHHVVLSIVGVDRLSYPGYLDAKKAQERLVADSGVPFTTVRSTQFFENLTAMGTGAAQGGVIVLPTADLQPIAAADVATTVADVATSAPLNSVVEIAGPERGAFTRLIAPVLAAHGDHRPVRSDAAAGYFGVPIVPDSLVPLGPARLGRTTFEDWSTTTLETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z453</accession>
    <name>A0A010Z453_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ORF">CryarDRAFT_3308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851774.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3265"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_11"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="411"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG82163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="874" mass="97341" checksum="24B9F6571BF8839E" modified="2014-06-11" version="1">MDLNRLTQKSQEAVHDAQTKALRFGHTEVDVEHLLLALIEQPEGLVPRLLSATGVDPGELQEKVEAELGRRPRVSGPGAAPGQVFVTQRLSRLFDAAEREAKRLKDEYVSVEHLVVAMLHEGPSSTAGRLLSEAGLTRNGFLQELTKIRGNQRVTSAMPEVAYEALAKYGRDLVADAAGGILDPVIGRDGEIRRVVQILSRKSKNNPVLIGEPGVGKTAIVGGLAQRITTGDVPDGLRDKVVFALDMSSLVAGAKYRGEFEERLKAVLSEVKAAEGRILLFIDELHTIVGAGGGSEGAMDAGNMLKPMLARGELHMIGATTLDEYRKHIEKDAALERRFQPVLVEEPTEEDAISILRGLRERLEVFHGVKIQDAASVAAVVLSRRYISDRFLPDKAIDLVDEACAMLRTEIDSMPAELDELSRRLIRLEIEEAALSKEEDSASLARLDQLRKELADLRAQVDALRAQWDAERQALRRVQELRREIEQLRHAAEQAERDYDLSRAAELRHGKLPELERRLQAEEQRLAAKQSGHRLLREVVTEAEIAGIVSRWTGIPVSRLTEGERRKLLRLDEILHERVIGQDEAVQLVTDAIIRARSGIKNPRRPIGSFVFLGPTGVGKTELARTLAAALFDTEDNMVRIDMSEYQERHTTSRLVGAPPGYVGYEEGGQLTEAVRRKPYSVVLFDEIEKAHADVFNTLLQVLDDGRLTDAQGRTVDFRNTVIIMTSNIGSQYLLEGISDAGEIKPEGRELVMGELRRHFRPEFLNRVDDIVLFKPLTQPEIERIVNLMFDELRERLNARWMTLEVTEEAQRFIARQGFDPVYGARPLRRFIAREVETRIGRALLAGDAGDGAVIRVDVIDGELTVAHGNPTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z552</accession>
    <name>A0A010Z552_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852295.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249612_0_0_11"/>
    <dbReference type="OrthoDB" id="1598814at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="21501" checksum="F3AC6203421AF041" modified="2014-06-11" version="1">MTTSPGGICGVVSGALFLVKAGLDLVVGEPPSDRARLPSWVDSHHLPLALTNETMALGAVLLIPLALALHQRLHGSAKPWAGIGCAALATAVPVILVLAVVQGRLVYPVYGIDLDAPATLALTISLYYGGAHLVSLLVGAALVVLGLSTRHPATWAVAGVAAGALQLVGAYPWLIGPVFTAITEAAFAAWLIVAGVTLTRPAPVLRPPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5I7</accession>
    <name>A0A010Z5I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852531.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="586" mass="62671" checksum="920FA95EF7498E00" modified="2014-06-11" version="1">MRAEHSLAGAWRTLWPWLRPYRRGLAIMVVADVLSLVAQTVTPFVFARMIDGPIRDGDHRGLWRYAAVLLGLAVLQTVCYGLRRWPTRDSARMEAALRRDLFRRLQRLSALHHDRHGSGQAVSRVIGDVTRVGFLHQETLVFLVSNTVALVVTATMLVIIHPVLGLLVVAAMIPLAVASGRFRTRFGRAARLAQDRTGDLATVTEEAVLGVRVLTSVGGWRFAAARFDRAAAGVRDAELAKVRLNASFRAGLTVYPLAVLSLVVVGGGVAVADGAVSVGSFVAFATLYLRMLFPVNVAGALLASLQEEISAARRIAEITAAEPDVTDPPHPVPLPPAPALSLRLDAVGFSYPGAGSPTLDGVDLDVAAGETVALVGATGSGKTTLVDLVGRLVDPGAGRVLIGGIDVRDLALDELRAAVGIAFEDATLFSATVRDNLVLSREHTSDAELDRVLSVARAEFVHALPDGLDTLVGERGLSLSGGQRQRLTLARALLGRPRLLVLDDPMSALDVRTEETIERRLRAEFGAVTTLLIARRPATARLADRVAVLADRRIVDVGTHAELMHRSAAYRHVLIAAETTTSGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6B0</accession>
    <name>A0A010Z6B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852811.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4007"/>
    <dbReference type="HOGENOM" id="CLU_020027_13_0_11"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="464" mass="50284" checksum="8D86CC8E9D40DC9E" modified="2014-06-11" version="1">MGDLDDIQSWLNDELPSMLAKYEVPAANWAVVRGDEVVDGAAGVLSKATGVDATADSVFQIGSITKLWTSTLVLQLVDEGKVGLDRPIREYLPDFRIADEQAAQTITVRHLLNHTAGFEGDIFVDTGFGDDCVEKYVAALHDVPQLFPPGEQFSYNNAGYCVLGRLIEVLRGTSFDASLREYLITPLGLTHAATDAYEAIKYRAAMGHVEPERGEGYQPAPVWAMYRSNAPAGAMLSMRARDLVAFARMHLDDGRVGEQQVLAPGTAALMQERQVDLPDLGLMGTSWGLGFERFDLPSGAIVGHDGNTIGQAAFLRMVPGTGVAVALLTNGGDALSLYKDVVGGALNRLTGVELPASPVPPAEPPTIDAERFLGTYSASVYDLTVSQDDDRRIWIEQTPKGFLEEIGGRVERTELVSYRDDMLIPVEADRGMYMPHAFLGDDGTGHALYLHLGRAIRRAGTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6N1</accession>
    <name>A0A010Z6N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035865462.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4149"/>
    <dbReference type="HOGENOM" id="CLU_129722_1_0_11"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="14521" checksum="C1208C3694A4C440" modified="2014-06-11" version="1">MTLPATGQPQRQPIASDEDVVRVRQLVRSVAVAVKLSLIDQTKLVTAASELARNTLLYGGGGVAEVTAVQNGLRRGVRIVFADDGPGIADIDLAMTDGYTSGGGLGLGLSGSRRLVDEFDLDTEVGRGTRITVAKWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6P1</accession>
    <name>A0A010Z6P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853099.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4159"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_11"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="31496" checksum="24066AC0D069C222" modified="2014-06-11" version="1">MAREYIVELPTHSVGVLEWGPADGEPLIALHGFPDTAWTWRKVAPLLAEQGYRVAAPFLRGYAPSGMPGDYSVRALAADAVALHERLGGTALIGHDWGAIIATTLAGDPANPYPRVAALAVPPLGLMNPTRATLRPWLGAMLRQPRKSWYIAYHQLPGRSERHFERLVRRLWNDWSPGYDATEDIDHLTRAIPDRAHASAAIGYYRERDFRPAFAAPRTPLLYLHGARDGALDRRYFAVAAPHLTPPSRAALIPDAGHFLHLERPEAVAGLLVDWLRTSPHESGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6Q8</accession>
    <name>A0A010Z6Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, dynein-related subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853156.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051820_1_0_11"/>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="29932" checksum="2B709C3236578B6C" modified="2014-06-11" version="1">MNRAELQDALRAQSYLADDGLVTAIHLAGKLELPLLLEGEPGVGKTEVATALARVSGRTLIRLQCYEGLDAANALYEWDYPKQLLHLRSGADLYAPEFLLERPLLAALRTPAVLLVDEIDRADAEFEAFLLEFLADFRITIPELGPIHAETPPIVVLTSNRTRDLHDALKRRCLYHWIPYPDAAREREIVRVKAPGLDERSAARLVDAVNAVRDLGPVKRPGVAESIAWARGARVLTDEGVPWPDALRRALGLLVKYEEDVRRAQEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK21</accession>
    <name>A0A010ZK21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569517.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.26"/>
    <dbReference type="HOGENOM" id="CLU_186178_0_0_11"/>
    <dbReference type="OrthoDB" id="2090823at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="76" mass="8010" checksum="65D52C944B263784" modified="2014-06-11" version="1">MYGWIWDHLPGNAALKSLCALILVGVVGWALWFKVFPWAEPLLPFGDVTVDGTGQTVDENNPTAPAETGAPTTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLY2</accession>
    <name>A0A010ZLY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848447.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.698"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26486" checksum="976819E0190F4731" modified="2014-06-11" version="1">METGRVHGRILDGVATVVLDNPAKRNAMTNEMWNTLPSLLDQLAADQDVAVLVITGAGDTFCAGADISTLTGFAPGEPMPATVAEDALVAFPKPVVAAIRGWCVGGGCQIAVACDLRIAEQGSRFGITPAKIGVVYPAATTARLVELVGPAAAKFLLFTGDFIDDERALRTGLVDELVPPGGLEARVGELARTLASRSRLTQHAAKDLIRATLDGRPTAEGYRRWAAEGAAELAEGVAAFAERRVPSFPWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMJ0</accession>
    <name>A0A010ZMJ0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848665.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.924"/>
    <dbReference type="HOGENOM" id="CLU_029499_1_0_11"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="33182" checksum="909F3798B406881D" modified="2014-06-11" version="1">MVETSAAKPRTTRKAVIPAAGLGTRFLPATKAVPKELLPVVDKPALEYIVEESAAAGLDDVLLVTGRGKSAMVDHFDRRPDLEKSLEEKGKTAELNAVRRSSEIASINTCRQGEPKGLGHAVLCAASHVGDEPFAVMLGDDLIDARDPILPTMLEVQEEHGGIVLALLEVPREHIKRYGIVAVENTGRTGEGHLGDIVRVTDMVEKPDPDDAPSNLAIIGRYVLPAEIFEAIRNTKPGAGGEIQLTDAMADLLKAGTPVHGVVFKGRRYDTGAKIDYLKATVLLGVDHEELGSEFREWLTDYVKTSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMQ6</accession>
    <name>A0A010ZMQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848730.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_2_11"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="22880" checksum="7CFB7D62188C7A6E" modified="2014-06-11" version="1">MGENVSFRTDGGTADGYLARPDSESGPGILVLPAWWGLGGQIRSVADRLAGEGFVALAPDVYGGTVVSDADEAQRLAEDLSADRVAADLVGAAGFLAGAVGGTIGAVGFGLGGSLALFAAGLSDDVIAAGAFYPLVPWQPTTPNWAAFGGTTAIVHAADEDASTTGPELELAKKAVEAAGGDLTVHEYPGTKRGFYNDDRPDSYDPHAAATAWARTLEVFRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMZ2</accession>
    <name>A0A010ZMZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein CryarDRAFT_1121</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848845.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1100"/>
    <dbReference type="HOGENOM" id="CLU_057596_2_0_11"/>
    <dbReference type="OrthoDB" id="1736059at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="20169" checksum="144CC4825550238A" modified="2014-06-11" version="1">MITGMPAEDLTGRLLVASPSLKDPNFERSVVLLIAHEPSGALGVVLNRATEVQVEDVLDGWQDFAAQPQVVFEGGPVQPEAAICLARVRPGTSPDGFSRVEGVVGTVDLSASPDAFNGSLDRLRVFAGYAGWDADQLESEIEQGAWLVLDALPGDAFMPQPEDLWSMVLRRQGGMLAALALYPADPQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP81</accession>
    <name>A0A010ZP81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847420.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.50"/>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_11"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="12"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="34727" checksum="1A49AD90535FF75F" modified="2014-06-11" version="1">MAQRYGTGDRILLTGGAGFVGSHLSDALLARGAEVVVVDNFLTGSRENIAHLVDEPRFTLVEADVIEGLPVTGRFDAVLHFASPASPTDFEKLAFEVMKVNSAGTFHCLELAREQGARLVLASTSEAYGDPEVHPQPETYRGNVNPIGPRSVYDEAKRFAEAAAAGYRRIHDVDTGIVRIFNTYGPRMRPDDGRAIPTFVSQALAGAPITVHGTGGQTRSICYVSDLVDGILAMLDSAEPGPVNLGSEHELTMRELAETIVELTGSRSTISYLPRPTDDPELRRPDLTRARQLLDFAPAVSPADGLARTIEWFATVGSPTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPE9</accession>
    <name>A0A010ZPE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidylarginine deiminase-like enzyme</fullName>
            <ecNumber evidence="2">3.5.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.12" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849492.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1609"/>
    <dbReference type="HOGENOM" id="CLU_037682_1_0_11"/>
    <dbReference type="OrthoDB" id="771174at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="36615" checksum="243B09DA79150F6C" modified="2014-06-11" version="1">MPPEWAPHEATWMAFPTPNATFDEHDSPSLAAARKAWADVANVIVGYEPVEMLVDEGDHSAARSLLDPRIHLVEVALDDAWLRDSGPTFVLDQEGGTRATAWRFNGWGAQSWAAWGRDRHLGTLVGRAAGVEVDRSPLTQEGGGLHVDGAGTVLLTETVQLDPDRNPGWTRAEVEHELHQRLGTTTAIWLPRGLTADYDEFGTRGHVDVVATFTRPGSVLVHTQPDPGHPDHAPMKEIAEILRTSTDAAGRRLEVVELPSPTVAEFEGRPVDHSYVNHYLGNGFVVGCAFDDPQDEKAAAILAEAYPGRDVVQVDARDIFRFGGGVHCITQQQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPH7</accession>
    <name>A0A010ZPH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type enterobactin transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849541.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_11"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="345" mass="35388" checksum="1DB02B299C71545C" modified="2014-06-11" version="1">MTAVPVLAAGPVVLRVHRRSVVVCLVLGVLLLAAIVLSLAAGTNSFPLDQVFTAVFGEGKPATELIVAELRLPRAVTGALVGIALGISGGIFQSLTRNPLGSPDVVGFGQGATTGALVTMLLLHGGFVAASFGAVVGGVVTAALVFGLAYHRGSIAPLRIVLVGLGLALMLISVNQLLIVRSQLYDAQSASAWIVGSLAGREWNQVKLMGAVLVVGLVACVFLMRPLSLSEFSDERSMSLGLRIGRARFAAVGTGVLLASAAVAAAGPIQFVALPAPQIARRLTRAAGPNLTASGLTGGLLLVLADFLAREAFQPRLVPVGVVTGVVGGLYLAWLLSREWKKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPU0</accession>
    <name>A0A010ZPU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol maleylpyruvate isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849715.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1749"/>
    <dbReference type="HOGENOM" id="CLU_107588_0_0_11"/>
    <dbReference type="OrthoDB" id="1654278at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="23041" checksum="21386FF98EE377C7" modified="2014-06-11" version="1">MEPVTGNDVSLSVNLLRRAFADVPDSAWRVPAGGLRWSCWETLEHLIDDLFTYAIQVAASNPPRDDLVPFDYHSARDGGPANSLFLQANAGTAGLLQALEVCGVFLGSAVRDAPPDRRAHHSFGLSDPEGFAAMGVVETLVHGEDLARGLQRPWEPPADLCARALHRLFPDAPPEAEPWPALLWATGRGSLPGHPDRKDGWRWDSRPADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ67</accession>
    <name>A0A010ZQ67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1857"/>
    <dbReference type="HOGENOM" id="CLU_017048_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="867" mass="93915" checksum="966C9A61D1D233AA" modified="2014-06-11" version="1">MSGERDAVVTRDLADAAAVPAPELLNLGVEEEFHVVDLDSRELVPRAPEILDHLPAASFSPELHRSVLETNTKVHIGLERLRDELIALRRQACQVADALGLGIVAAGTVPLVDVEELAVTPNARFERMLDDYQLLAREQLICGAQVHVGIPDRDVAVAVAQRVSQYLPALLAISASSPFWMGEDTGYSSIRSLLWQRWPTAGASGLVETAEDHDSLVAELIASGTITDPGMIYFDVRPSAHVPTIELRVTDACPSVDTVVLLAGLFRALVRRERDAVANRYPLTRIRGPLQRAAMWRAARSGLEGDLVDLSGFARPVPAGEAIRSLVGSLRPQLEAAGDWEYVSALAGQALARGSAADRQRRVFARRGRLADVVDMLLAETRAGGAVTVGGFGGQEALLAGYQQEQARGDEVIASDGSVVPVYEPMLQLLERLGAGGIRDREKERDAEQRSHRMTFRVAGETTARLFPLDVIPRIVSGEDWEALGRGLVQRARALDAFLKDVYADREVVEDGVIPAWVVDGAPGLLPLAALIRQPVRAHIAGMDLVHDAAGNWSVLEDNLRVPSGLGYSVANRRLTDHIWPDLPRPAGLHSVETLPALLRSTLEAAAPPRTSTSPQIVVLSQGPVDSAWFEHQLLAEEMGVPVVRTTDLVVDDRTVYLHRHGTRRRVDVIYLRLDEDTLVHAPAGDGRPLGPPLLSAVGAGTVTLANAPGNGVGDDKAIYAYVPDFIEYYLGEKPILAHVPTYLCGDAEQRDEVLRRLGELVVKPVDGYGGEGVLIGPRATEEELDAVRRQIKAAPHRWIAQETMHLSTHPVFDGNRLTPRHVDLRAFVFMGENPTVAPAALTRVAPEGSLVVNSSRGGGAKDTWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ78</accession>
    <name>A0A010ZQ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849899.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459204" evidence="2">
        <location>
            <begin position="31"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="34350" checksum="F917DAE61091FA34" modified="2014-06-11" version="1">MTRSRAIGSAVVALAALALALVVSPEFRPARDTPTVVGVVVLAVLVGAWPNTRWWIGPAAASVVVATAAGVASWLPNPTIGGGIWSLELTAVLMVLLALLCRWSPPAWVVAVAPAGVFVESTLILQTTGAPVMTGWEAVGACVFWSLAGLVGTGSGLYLRQLDGRRAAAVTNARRVQRVRLAADLHDGVAHDVSAMVLQAQAAKVLLGERAGDVASVLDRIEADGTRALASMQRSIHVLREGEADRPIPQPELPVVQRVIAEALRNAEKHGDGGGVTLVITNPLPSTRRPRGPGLRYGLAGLADEVEAAGGTFSAGPDGDRWTVRLELPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQX1</accession>
    <name>A0A010ZQX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569674.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128197_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="20475" checksum="EADDF31B3327E85C" modified="2014-06-11" version="1">MKVTFVRLPDHEWGDVLIERDDHVVYRMHGGPVTAALPHDLVHFTVEDALRIEDGIWGAIAAGVVFQSMKHVSGRRPPHAADRSAQLIRANRDRLQRAELIGGFIEAAAKADGDLPALRRQWFATQPDAPDLPAIELAVAALHRAEERWRALPAGAELTVTWPAHRRLPALPTGKRSKTPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRF8</accession>
    <name>A0A010ZRF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850470.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="30417" checksum="0CCC2BF72EAB80EC" modified="2014-06-11" version="1">MDLRHLRSFATVARTGSFTAAAAELGFTQSAISQHVAALEADLGRRLLHRRPVRLTEAGTRLLTHAQHLLLRADVARQEILRRNAHRPATIAVTPLAAGDRLLGALGLVDLVEVVLGSADEAVSRLAAGTVDAAAVDGVTAPNGPLGVTEPGVLTRALIAETRLEVLLTADHPLATAGGVDLDSVRDARWIDAPDLRCDVPGAAAPTTTGRLRYRGTDLSLLARLVARGHGLALLPSGLAPETAGVARVPLVRPDVVHRTELLVPRGRADQLSALLAGVVAGEFTENLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRP7</accession>
    <name>A0A010ZRP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_2404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570052.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2367"/>
    <dbReference type="HOGENOM" id="CLU_080384_0_1_11"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="23887" checksum="AA8B6BDBE782674B" modified="2014-06-11" version="1">MLSQARDRIQRVTGPIGTALVRTGLTPDAMTLIGTTGVVLSSIFLVVPGHVLAGGLAITFFALTDMLDGAMARARGWSSRWGAFLDSTCDRLADASIFAAAAYWLFREDRDSAGIAALLCLITGVLVSYAKARAEGLGLTANVGIAERTERLVLVGLGGVLEVLGVPGGIEWILWLLTALAAFTVGQRVHAVWTQTKDDRVRPDRRLDTGPVPPPNGYTESPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRT1</accession>
    <name>A0A010ZRT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022017_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="366"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="536" mass="55270" checksum="61BE73081E6A9F40" modified="2014-06-11" version="1">MTAVEDRRSAELRGIARAGTISLIGSAASAVLGFALVVQVSRGLGAAGAGAFSVVVAVAMTLAVAGRFGTDTALVRMAPRLRALGRARDIDAAAVAALAPVFAGTTLLAALAWWAAPHLVDVVFEHPAPAGAVWLIRVGVATVPLAATGYVALAVTRGLGSVVPLTVVESIAKPALRCAFVGIALAVAHRRWPGAELTAGPVLWTTIAWAVPTVLGGLWAAVLAHRALRSVRDEPSTEHVGAKATWRELWRFATPRAAASACEIAGMHSGIILVSALAGVAEAGIYNAALRLALAGTLALQALRLAIAPTLARLLTVGDLDGVEHLHRTASVWITVVSFPLYLVFAAWPTEVLRMFGPGFQAGGAALAILAAATLVNLATGPVSTLLLMSGRSTLTLVVTAASLTFSVVLAVVLIPRYGVLGAAIAKGAAVVGENIAVTLIVRRSVGVRTLSRPLVRAAVVGALCFVVPAGLYQLVAGHDFPAAVVVVLLGTAGYLALLWRHREEFSLADLAAALPLDRLRPRRPKVGPRSSKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS18</accession>
    <name>A0A010ZS18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850799.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2536"/>
    <dbReference type="HOGENOM" id="CLU_054590_7_3_11"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="26575" checksum="EDBE565111164A60" modified="2014-06-11" version="1">MGARSVQIPTPDGVADAFVAQPDGDGPWPAVLFYMDAFGVREVLTDMARTIADDGFVVLLPNLFYRSGTAPLFDTSGLATPEGRREVFGSARPMIAALTAEAVKGDAAAYLDFLAAEPSVKPGPVGVTGYCMGGRLAVRTAIAFPDRVGAVASFHAGGLVTDEPDSPHRQVTGAGVEYYFAHAENDHSMTPANVTALNDALDAAGVRFKSEIYEGTEHGFTMSDSDVYDPMSLERHWRNLLELFERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSK5</accession>
    <name>A0A010ZSK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849006.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097062_2_1_11"/>
    <dbReference type="OrthoDB" id="2047691at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18999" checksum="56C154196C9DD691" modified="2014-06-11" version="1">MTPMTDRRAPFIVGDERTTLLSFLAYLRQSIVRKVEDLSEDEARRAITPSGWTLAGLVKHLTVSERYWFRHVWAGEPGAEWDRHSWDVPADVSVDQLVDDYREAWKESDRLIEAAPNFDVPCAEEHRNHRMSLRWVIVHMIEETARHAGHADISREHIDGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSQ6</accession>
    <name>A0A010ZSQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851150.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2810"/>
    <dbReference type="HOGENOM" id="CLU_170430_0_1_11"/>
    <dbReference type="OrthoDB" id="1811614at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="93" mass="9876" checksum="1A64071CF966FEB2" modified="2014-06-11" version="1">MCRNITELRGLQPPATEDEITAAAAQFIRKVTGIGKPNPGVAPAMDEAVQQIAEITRGLLAQLPARRGEPATVPPLRRPAVRARLGLGPFDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZST3</accession>
    <name>A0A010ZST3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849074.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1303"/>
    <dbReference type="HOGENOM" id="CLU_060077_5_1_11"/>
    <dbReference type="OrthoDB" id="1677723at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="17094" checksum="D38024158B0066B5" modified="2014-06-11" version="1">MNDLLTMGDVSHRSGHAPSALRYYERVGLIEATRTTGNQRRYHRSVLRRLAFIRAARHVGLSLEDVRDALATLPAGRTPTRQDWTRLSRSWRSRLDEQISALMALRDGLDSCIGCGCLSLQRCRLSNPGDRAAGAGPGAVYLPRLLRDPVGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSU9</accession>
    <name>A0A010ZSU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849101.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1322"/>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="30742" checksum="8E2FBA08A15465D2" modified="2014-06-11" version="1">MSGAATPTVVRRQLGRRLRLLREAAGVSVESVVADRRLGISRAKLYKLEAGKHPAKPQDVAALCRHYRASNEEIEALTTLALATQGSSWWHIFGEDTVPAWFSLYVDLEPAAASIRSYEAELVPGLLQTPEYALAVYQARNPTDDVNDLRRRVAVRMERQAILDRPTPPAFHAILNEAVLLREVGGPAVMAAQIDKLRGAADRPSTMIDVLPFKAGAHAAMESSFGILDFPDAEEDPSVVYLDSPSSAAYLQQRAELERYTTIFETVRTGTIPLQEYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSZ9</accession>
    <name>A0A010ZSZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1377"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="532" mass="59500" checksum="50CE17672A66930E" modified="2014-06-11" version="1">MGSETIPEPRGYILAGTWWRDAVFYQVYVRSFADSNGDGVGDLAGLKSRLPYLADLGVDALWLNPFYRSPMADHGYDVADPRDVDPVFGTLADFDDMVAEAHRLGIKVTVDLVPNHSSDQHVWFQEALTAAPGSPERERYIFRDGRGPDGSEAPNNWTSVFGGPAWHRVTEPDGTPGQWYLHLFAPEQPDLNWDNPEVMADLEKTLRFWLDRGADGFRIDVAHGLAKPPGLPDMEAVKETLAGDGHPRFDYDGVHEIHRRIRKVLDEYPDSMAVGEIWVQDVERLKLYLRADELHLAFNFVIVQARWRADELRKAIDDSRDTVSGTPAPPCWVWSNHDIVRHVSRFGEGLVGDRRARAASMLTFALPGVVYVYYGDEVGLPNVELPDEVLQDPTWERSGHSVRGRDACRIPMPWTPGEPPYGFSPEPVDTWLPQPAGWSPLAVESQVGVEGSTHTLYKEAIALRKAREEFSGEMTWLDAPEGCLAFRRDGGLTCLVNFTNHPVELPEHRELLLTSVPLVDGKLPGDAAAWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT58</accession>
    <name>A0A010ZT58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2960"/>
    <dbReference type="HOGENOM" id="CLU_581032_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="470" mass="50721" checksum="369A03DC95FED5CC" modified="2014-06-11" version="1">MSTNHTDADVVVVGAGPTGLMLAAELGLAGVRPVVIERHPEPRTVARAGGLGGRILELLRHRGLLDPLRALADDPDPAPRFPFGGVHVDLTGLADAPMHAIAIPQARLERLLDDRARELGADVRRGHEVWRVTQDTDAMTVGTRDGERLTARWVVGCDGPRSAVRTLAGIAFPGTTYPEVNRLARVTVPGLPDGDLDVHGVGRLSVGFTRTAGGVFGYGGITDGVLFANTVEDELVEYDDDQPMALAEFGDSVRRVLGVELPMGTPLRLSRWQFQARQAERYRDRRVFLAGDAAHLLPATGAALNLGLLDAVNLAWKLAAEVHGWAPGPPGRRPPVEGPGRRQHDRDRRPPGRRPPDPPRRPRHLGRHRPGGAGTSPHDLVRLTPRARPRPARPTSPGSCSTAYGRGDDRSSHRWAFGHARFTGSDGNTHPPSTYSPRSAASKPSFDGNPNRIGRPSSPHTGQVEFTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT63</accession>
    <name>A0A010ZT63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1448"/>
    <dbReference type="HOGENOM" id="CLU_1376175_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="18418" checksum="ACC3E4A64C149A03" modified="2014-06-11" version="1">MYGAGPASGAASVGANPAGSFGGPAPANAPGTAPPIYNGAPAVGGAAVGGVAAVGGAAPAVPMGGVAPVSGAASGPTAPVGWNVTGDIPSAWSEDRPRGASLEPPDLGPSATQPIFTKMMLLGLTGAGLVIAIVSCLLGSVVGIPLRGESAPEVNVKVSVSPSPVYVTVTPSAPDGAAPSDGTPSDGTPDPGDGAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUA0</accession>
    <name>A0A010ZUA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849819.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1814"/>
    <dbReference type="HOGENOM" id="CLU_100689_3_0_11"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="106" mass="12041" checksum="BC6ABBF3B3CEAE1C" modified="2014-06-11" version="1">MQRVCLLGRVDPSRLDEYRERHAAVWPEMLAALTRHGWTNYSLFLKDDGLLIGYLETEDYAAGLAGMAGEEVNARWQAEMGPFFVGLGDRRPDEGFLIVPEVFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUE0</accession>
    <name>A0A010ZUE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570416.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192632_0_0_11"/>
    <dbReference type="OrthoDB" id="1647498at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="11535" checksum="5B869A6180455800" modified="2014-06-11" version="1">MGLSAVLAGWADRHGRELALELRGPLLPSGMDPTWLLSFTGGSSDGQIALFRGPVVDVAAYRWARPHEGMCVGGAFGVADDHFDRMLDDLLAMDCGGPVPNWLKLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUL6</accession>
    <name>A0A010ZUL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569977.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042141_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="4">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="294"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="39866" checksum="8180C03C7833008C" modified="2014-06-11" version="1">MPPSPTTGDRRPAGFTVEVTGWRALAAFRFLTLVYAVALNLDDLGRVDSPAWCVATLAVMGAWSVASSYCYARPRLRTPVLFVVDLAVTLATVLATRLVETPERIAGGEFTVPTVWASTAVMAWALRWEIVGGLLATLGLGAANVVVVSGQPTRGTVHNMILVLLAAIVIGYVAEVLRQVDRLMVDAWQEQGAVAERDRLARQIHDGVLQVLALVKRRGSTLDGEGRELAELAGEQESALRALMTSGSAAPSDGVVDLSALLAPLAASPGIELVAPAEPVLLPAGAGAEVAAAVAAALHNVSEHAPGAHAWVVVEEERDAVLVTVRDDGPGIPPERLAEAAAEGRLGVVQSIRGRIRELGGTVVITSAPDEGTEVELNVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUS6</accession>
    <name>A0A010ZUS6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliP</name>
        <name evidence="14" type="ORF">CryarDRAFT_2057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850095.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2022"/>
    <dbReference type="HOGENOM" id="CLU_042028_3_1_11"/>
    <dbReference type="OrthoDB" id="1049349at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458416" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="28833" checksum="963A14B0377415B9" modified="2014-06-11" version="1">MRRRAAGLLLLGFVIALVIWGDPAPAPAAPLSTPVVEPAAPTPPVPPGGQVTVNVNNGPNGKPSTAVTLLIALTVLSIAPSVMLLCTCFTKVFVVLSIIRNALGLQTIPPNQVLAGLALFISIFIMTPVLSQVNSQGVQPYLKGTKSQTEAFQDGVQPLREFMLKHTRKDEIALMNRVADKPRPKNKDDVSLPVLIPAFVLSELRAAFIIGFVIFLPFIVVDMVVSASLMSLGMMMLPPVMVSLPFKLLLFVMSNGWTLVVTALVASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVE8</accession>
    <name>A0A010ZVE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852605.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3836"/>
    <dbReference type="HOGENOM" id="CLU_137245_0_0_11"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="148" mass="16425" checksum="62AAC0FAF4875227" modified="2014-06-11" version="1">MVDILHRVGVHGVPPDEVFEALTTAEQLAGWWTEDTTGDGRAGGRLQFRFPPVGGFDMDVVATRPAARVTWRVADGPAEWIGTTIDWTLRRDGDYTIVLFAHRGWSEPVEFMHHCSTKWATFLLSLKARLETGRGAPAPGDVAISDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVT3</accession>
    <name>A0A010ZVT3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">CryarDRAFT_2423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850597.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2386"/>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_11"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="419" mass="45768" checksum="0B8C0DE8C2101F49" modified="2014-06-11" version="1">MTSFTAPKGTFDTLPPDSATFLAVRDALTAPLRRAGYGYIETPVFEDTALFARGVGESTDVVSKEMYTFTDRGGRSLTLRPELTAGLMRAFIEHKLYAGQLPVKLYAVGSNFRYERPQAGRYRHFTQVDMEALGVDDPALDAEVVALGVAGFAELGLTNYELQLTSLGDAGCRPQYREKLQEFLAGLDLDEETRRRAGLNPLRVLDDKRPEVAAQLTEAPLMVDHLCDDCQKHYDEVREHLRDLGITWTEAPRLVRGLDYYTKTTYEFVHNGLGAQSAIGGGGRYDGLSKELGGPDVSGIGYAVGVDRTLLAMRAEGLVGEPQAKVRAFVVPLGDEARRRGLQLLTELRNENVAADFAFGGKSLKGAMKAADRSGARYAVVLGERDLADGTAQLKDLTTAEQRAVPLTDLARTVKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVW0</accession>
    <name>A0A010ZVW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">CryarDRAFT_2453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2416"/>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_11"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="179"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="41619" checksum="8DBAE6864076DCBC" modified="2014-06-11" version="1">MLGVAGGIAAYKACELLRRLTESGLSVTVVPTESALEFVGAPTWAALSGRPVATDVWTSVHEVPHVALGRRASLVVVAPATADLLARAANGLANDLLTNTLLTARCPILFAPAMHTEMWEHPATQANVATLRSRGVVVLEPAVGRLTGPDTGKGRLPEPAEIADVAFSLLRRGAAEPDLSGRRVVVSAGGTREYLDPVRFIGNRSSGRQGYALARTAAARGAKVTLIAANTALPDPAGVDVVRVVSTRDLQEAVFAAGADADVVVMAAAPADFRPADYVETKIKKSGDTDAPVVTLMQNPDILAGLVRRRRESGGGPVIVGFAAETGDTTGSVLELGRAKLARKGCDLLVVNDVSDGKAFESTENAAVVLADDGTSTEVPHGPKEVLADTIWDLVAPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVY9</accession>
    <name>A0A010ZVY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852814.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4008"/>
    <dbReference type="HOGENOM" id="CLU_038556_0_0_11"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459249" evidence="1">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="530" mass="53879" checksum="B780E729C2A3B521" modified="2014-06-11" version="1">MKRTRMASYGLCLTLALAGCSGAANNGAGDGAPVVDGGTFTLGLSSDPGALDPQMGAGTSLFTVTQFAYDPLVSVDGESGEIRSALATSWKAEGTTVELTLNEGITCDDGSALTATAVADNLNFVADPKNSSPFLGVFLPAGVKAAGDDASRVVTLTLAQPAPFVLNGLASLPIVCPSGLKNRAALTKTTSGTGPYKLVEAAPGDHYTYQVRDGYTWGPDGATTATKGMPKTVVVKIVENESTAANLLVSGGLSAAQVAGPDSARLEKAGLFTAETPALSGEQWYNHAKGRVTDDPQVRLALTRALDLAQLQKVLTSGKGSAATVLATNAPAACPGDSVSKSLPSHDPAAAGALLDQAGWTKGADGTRAKAGKPLKLTFLYQNTSGSGGNAAAELAVKQWKAVGVDATAKSQNETTLTGTIFGAGDWDVAWVSLNVNSPDQLVPFLSGPAAPKGTNFAAIADADYTEAVTAAAALPGAEGCDKWLAAESDLIKKASIVPFANTTVRTFGKASKFETPGQLVPTSIRMLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWD5</accession>
    <name>A0A010ZWD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_4185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853102.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4160"/>
    <dbReference type="HOGENOM" id="CLU_002346_0_0_11"/>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="8">
        <location>
            <begin position="645"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="919" mass="101279" checksum="1A637385EBDC6D92" modified="2014-06-11" version="1">MELARKGPGEGSLPPRARLNSSAPRQSLNGTWEFRLDEGEWTTIPVPSHWVLEGHGKPAYTNVRYPFAIDPPHPPDENPIGDYRLTFDAAEDFRDGAVLRFDGIESAAEIRFNGQLLGTTRGSRLTHEFAVEPRATGNVLEVRVAQFSDASYLEDQDMWWLPGIFRDVDLVATPAGGLRDVFAVADFDPGSGTGTLTVRTSAQARLRIPELAVDQTVHDSVVAVGTVQPWSPETPRLYAATVSTDAEEISLRLGFRRIEVCGAVLEFNGNPIQFRGVNRHEHHPERGRVVSPEDTRAELELMKRHNVNAVRTSHYPPAPGFLDLTDELGFYVVLECDLETHGFVEVGWRDNPSDDPEWESAYLDRMRRTVHRDKNHASVVVWSLGNEAGTGTNLEAMAAWTRAFDPSRLIHYEHDWASTYVDLYSRMYASHDEVERIGEEVLSPAPFGATPAELHRRELPFIQCEYAHAMGNGPGGLEEYQDLFDRYPRLAGGFIWEWVEHALAVTGSDGKRRMYYGGDFGEDIHDGNFVTDGLVSADREVRPGLTALAHWFSPVRIEVTASTVRIRNRYDHVDLGHLTFRWRTGDAGGVLSVPRATPGRTVEVPLPPEASGPWVTVEAVADAEHVIGSGQFTRFAPTGRPAPTTLPTREAFDPVSMRLRTLGGLTLDGPLVSLWRAPTDNDRYPGWDEPGLPPYAERWTEAGIDRLRTRLVSAGEVDGALRTVHRSTPPGRDFGVDSEFRWHQVSPDALLLDVVVTPRGVWPVEWARLGLDLVLPGAPAGLDWLGLGPGPAYPDLAAGVRYGTFHAEADELYTPYVRPQESGARRGVRTATVATSAGELRVTVLGDDEIAVTVSPWSRALIASTLHHHDLVADGRTYVSLDLAQSGVGTAACGPGVLPRYRLPARPARISLLLEANPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWH0</accession>
    <name>A0A010ZWH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaK suppressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850927.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2645"/>
    <dbReference type="HOGENOM" id="CLU_043144_3_0_11"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="115" mass="12013" checksum="A92C0E74EA6F7780" modified="2014-06-11" version="1">MDDVHRALTDERADTAAQVSALSADLDGIIEAAAMSNTDDEHDPEGTTIAYERAHTAALLSSARGRLDELDHALARHASGDYGRCESCGGSIAPERLAARPSTAFCIACASAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWP2</accession>
    <name>A0A010ZWP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862204.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2722"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="27065" checksum="CBAC91E8D83BC271" modified="2014-06-11" version="1">MRGLAGKVAVVTGAAGGIGAATAGRLAAEGAHVVAVDTADTVDTAGPPSADGVWVRADVSTEEGVAAYVDAAVERFGRIDLHHLNAGIAGSLTPLPDVPAAEFDRVMAVNVRGVFLGVRAAFRQFAAQGSAGNIVITGSIGSLRGSADLLAYQTSKHAVVGLLHGAAVYGGPLGVRVNAVAPGIVPTDLFGARGRDDMTRRASSTPLRRAGTGDEIAGVVAFLLSDDAAYVTGELVSADGGANVVSTVRPSGGAGAWDFAAHDRALYGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX77</accession>
    <name>A0A010ZX77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570206.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2904"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="24750" checksum="B151A76943D6D147" modified="2014-06-11" version="1">MASPPLLEASGLGKRYGRRTALADCTLSVPPGRIAGLVGPNGAGKSTLLQLLCGLLRPTSGTLRVLGERPGARLGRVGFVAQDAPVYADLTVADHLRLGAHLNPGWDAAFAARRVDALGLDRGRKAGRLSGGQRAQLALTIAAGKRPDLLILDEPAAALDPLARTEFLRHLRESVTELGAGAVLSSHLLSDVERVCDYLIVLAGGRLRLAGDVRSLLAEHSAPTLEELVLTHLSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXE2</accession>
    <name>A0A010ZXE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851361.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2977"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_11"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="27170" checksum="A5A78ABFA5D3FA0A" modified="2014-06-11" version="1">MSRVFITGSADGLGLLAARQLAGEGHRLTLHARREERADQIRKALPEADVVVGDVSTLDAMRSVAEQVDALGPHDAVIHNVAVGYQEPRRIETADGLAHVFAVNVLAPYVLTALITPPARLVYLSSGMHQSGRPDLDDPQWVDRRWNGSRAYSESKFYDLMLSRAVARRWPDVRANAVDPGWVPTRMGGRGAPDDLRLGADTQAWLAVTDAPATGAYFYHREPHSALPSTAESEDALVDYCATLSGIPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXN8</accession>
    <name>A0A010ZXN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1583752_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="18409" checksum="6D43B55156473425" modified="2014-06-11" version="1">MGANMIARVFYLPADTELDSAAATAVIEELCANASVDDLRILIENGWIEPALPHGEDAWTEAARVEELRAAAQHHMLILFERFRRSLTGRDVQRHRFAPPDQPGLDAYTTGGLSWGEGPTDAFDAWDLVFDVDRFPESWADRIGAAAGLLHPWGGGPPAVAAEFRAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYA7</accession>
    <name>A0A010ZYA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851821.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3301"/>
    <dbReference type="HOGENOM" id="CLU_1137031_0_0_11"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="28381" checksum="0AA54A199EBC2F0A" modified="2014-06-11" version="1">MAGHSTAGTWEPIVTPWHLDEALRNFPVPVTATQVIVPPLPDGSVAARMNRLHQAAADVVAQASRPLVLSGDCPTSRAAVSVVQRRHQDLAVVWLDAHGDFNTPVITTSGYLGGMALAMLTGRTPDLFDDTLGLTPLPDTSVVLADGRDLDPAERDSLNASQVRRVSADPTAVASALGDLGPTPVYLHLDIDVIDSAELRGARFPSGPGPSLSQIEECLTAACAIADVRGAYLACAWLPDHVGQPTSRDTITRLTRALGADLAWPESGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0D1</accession>
    <name>A0A011A0D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4126"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="40907" checksum="646329627C64876E" modified="2014-06-11" version="1">MMSRVRAHQALLTDLLLAGVTGFLSLQAEQTVELPWRVPLAVIGVGSILLRRRYPLPVLVFVTLVVAGGVVSGFLFPALALGMGVLMYSVALDLEGRRPWGYAALVSAAVCVPGLILHFDMWWGVNSFAVPVWIFGGAAIGDSVRSRRAYIAEVTERARQAELTREEEARRRVIDERLRIARELHDVVAHHIAVISVQVGAATHVLRRDPEQVWPVLTHIRSAADTVLTEIQSVVGVLRDPNEVTSTEPTPGMDRLPALLEDLRAMGFAVSFAEHGEHRALPAMTDITAYRILQEALTNARRYGDGSASLSVDFGTEEVRVTVENRIRPSAAAGSGFGLLGMRERATAAHGTLETGPTADGSFRVHAVLPLRAEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACB5</accession>
    <name>A0A011ACB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848456.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2768873_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="69" mass="7526" checksum="61568E5C2C720930" modified="2014-06-11" version="1">MSPAPRAARTESARGCAHREAAWKVELSARLCTDRAHAARLRGLAAWHQRQADHFDQLFGDDGTSPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACM0</accession>
    <name>A0A011ACM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848537.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774289_0_0_11"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459435" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15036" checksum="CCC53D341D00F727" modified="2014-06-11" version="1">MTPRVVVGAAAAGLLVLTGCASWGPEGGPGGLGRSDAPVTASTSAAPAVAAIRGPDGVQRITVTMTDDLRFEPDRVRARPGVIEFRLQNVGVTPHDMTVVENTAGNVNGGQTATLRVTVEKPGEYPFPCLYHAESGMRGVLEVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACQ2</accession>
    <name>A0A011ACQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848602.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.851"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28208" checksum="16B363997FF5BE21" modified="2014-06-11" version="1">MTNKPFAVVTGASSGIGYELARQFAAHGFDLLITAEDEDVNAAAIDLRRDAGHRVDVVQIDLASTSGVEHLHQAIVAAGRPVDAIALNAGRGAGGDFVRDTDLRDEMEIIDVNVRSTVHLAKRVLPAMVERGEGKVLFTSSIASTMPGTYQAVYNASKSFVQSFAEALQAELRGTGVTVTSLMPGPTETGFFERADMLDTKVGASDSKDDPADVAKQGFEALMKGESRVVAASLTTKAQEAAAKFLPDRAKAEMHRRMAEPGSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACR0</accession>
    <name>A0A011ACR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848612.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.861"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="31211" checksum="FDFADF48B4392A95" modified="2014-06-11" version="1">MADRAQLADFLRSRREALQPEDVGLPRGPRRRTGGLRREEVAALCGMSADYYSRIEQQRGPNPSEQMLAAIARGLHLTLNERDHLFRIAGHTAPQRAIRTDHVNPGIMRILDRLDDTPALVMTRLGETLRQTRMAKALLGDQLKFTGMARATVYRWYTDPRSRVIYPEDDHPIHGRAFTAKLRDAYLAEGSGSRSAALVDALLAESPEFAAVWAEHDISAGHPEFKRINHPELGILEVQCQTLLDPDQSQSLLVFTATPGTESYEKLQLLSVIGDRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACT8</accession>
    <name>A0A011ACT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101455_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27891" checksum="CC5DB52CC02C8912" modified="2014-06-11" version="1">MNSREILIAFTGGGSVPLGNVWRITAKKTDFYIDPLGDAGLAHLSVHGPNEDNPGAHRFHIKVDRRAAAEAQSRGDFVAHSVFRKGHPYDGQRVAPGAYRVARIRWTWDLQRPRYRNAAPVTHPLPEITPNRFGARLSKELEPNQAADVDLVVSYGEPHWPEGPGSLRDNARLGPLENEAGMFLTATSFRRSQMVRPAPTGLVPRLPRPGEEPARLLCAGPGDDGAMDMYWFVEAITSRELLEASREEIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACU9</accession>
    <name>A0A011ACU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569737.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.911"/>
    <dbReference type="HOGENOM" id="CLU_033536_7_1_11"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="37283" checksum="68DB22E32B09A66F" modified="2014-06-11" version="1">MNADPTTTLPEAAPHARHASISGGDPADPQASLNELDHGPNTLDATIVLPCYNEGPHVLLELERITKAMDASGFRYELLVIDDKSTDNTLQVLQEALPRFPRMRLMPFQRNGGSGTARRIGSAEAYGRIVVWTDSDMTYPNERIPEFIQYLIDHPETDQVVGARTTEQGTHKVLRVPAKWVIRKVAETLAGTKIPDLNSGLRAFRRDVSLPYLRLLPPGFSCVTTITLSFLSNQHTVDYLPIDYAKRAGTSKFHFVRDAYRYILQVLRMVMYFNPIKVLMPLALVLLGVGVTKAIVDVIIYFFRITTNSLLLIVTGLLIASVALLADLIVRSRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADI4</accession>
    <name>A0A011ADI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1156"/>
    <dbReference type="HOGENOM" id="CLU_001265_58_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="375" mass="36341" checksum="24CD576D41AC5AF8" modified="2014-06-11" version="1">MVLAAGVAGMTAGCAFLYGLPYLLPRLRADGLSLTHAAVLVACPTFGLLATLVGWGALADRYGERGVIALGLGGAGLVLLGAPAVSGPVALGACLVVAGAAAGSVNAASGRLILGWFSPAERGLAMGIRQMAQPLGVAVAAVAIPVLSRAGAFTFLAAGCLGAAALVAVVVRDPARSAGVAAGPSGSPYRTPVLLRLHGAGALLVFPQFAVATFGLVFLVDSARWDAATAGRLLAVAAFGGAAARLGAGWWSDRAGSRTGPMRILAGVTAGVLALLALAGAVGAPGVAVVALVVAAVVSVSTNGLSFTAVAEYAGPGWAGRALGIHNTGQNGVAALTAPVLGAVVTHAGYPVAFASAAIAAALAVATVPTLQLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEC6</accession>
    <name>A0A011AEC6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="14" type="ORF">CryarDRAFT_1464</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849243.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1439"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_11"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="25"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="695"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="610"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116227" checksum="AB43833AC6B03FC6" modified="2014-06-11" version="1">MAYPQNDPKKPVPAAASFPEIEQRVLDHWSSDATFQASIDARPAGENGSNEYVFYDGPPFANGLPHYGHLLTGYVKDLVPRYRTMKGEHVERRFGWDTHGLPAEVEAERQLGISTKAEVLDLGIAKFNDACKASVLRYTQDWERYVTRQARWVDFENDYKTLDTDYTESVLWAFKTLFDKGLIYEGFKVLPYCWRCETPLSNTETRMDDVYRSRQDPAVTVAFTLETGEKLWVWTTTPWTLPSNLAVAVGPTFEYAKFSNGTETVILGAARTGAYEKELEGFEQVGTVTGADLVGLRYTPLFDFLTGRDDVDNAWRVLSGDFVTTEDGTGVVHMAPAFGEDDQNLCNANGIPTIVTVDEHTRFTALVPPYQGLQVFEANKPISRDLREQDKVVRQDSYEHPYPHCWRCDTPLVYKAVSSWFVEVTKFRDRMVELNKQITWVPGHVKEGSFGKWIANARDWSISRNRFWGAPIPVWKSDDPTYPRVDVYGSLDEIERDFGVRPDDLHRPYVDDLTRPNPDDPTGRSTMRRVPEVLDCWFESGSMPFAQVHYPFENTEWFENHYPGDFIVEYMGQTRGWFYTLHVLATALFDRPAFTTCVSHGIVLGNDGTKMSKSRRNYPDVYEMFDVYGADAMRWFLMSSPILRGGDLVVTESGIRDSVRQVLNPLWNAYYFFTLYANAADYSAVRRTDSTNVLDRYVLAKLRDLVSDTTESLDVYDISGACAGVRSFFETLTNWYIRRSRDRFWAGDADAFDTLYTVLETVTRLTAPLLPMLTEEVWQGLTGGRSVHLCDFPDASELPADAELVAAMDRVRDVASSALSLRKAKKLRVRLPLASLTVAVPDAAALEPFRDLLADEVNVKEVLLQPDVDLACSNVLTVVPRALGPRLGKDVQRVIKAVKAGDWSSADGTVVAGGVPLQDGEYELKLVPTEPDRSAALPGNVGVVVLDPELTPALLAEGVARDVVRAVQQARKDAGLDVSDRITLRLEAPDDVVSAVRAHQDFVAAEVLASAVEFGPVADAAHAAEVGEGAPIRVGVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF53</accession>
    <name>A0A011AF53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849651.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1715"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_11"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="24507" checksum="CB1CF2100E1F9469" modified="2014-06-11" version="1">MKIAGAVALVTGANRGLGRHFATQLLERGATKVYATARTPESIDIPGVETLRIDVTDPASIEAAAAVAGDVTLLVNNAGISTGTELLQGDLADIRRELETNFYGPLHTVRAFAPVLERNGGGAIVNMLSALSWFAYPGSGAYSAGKAAAWNLTNSIRLELAPRGILVSGVHLGLADTDMAAGLDMPKTPPADVVRTVLDGVEAGALEVVVDEWSAGVKASLSRDPGEFYGDAARPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF57</accession>
    <name>A0A011AF57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849660.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="31264" checksum="E008D7BF867E9EEC" modified="2014-06-11" version="1">MELRHLEFFVAVAEEQSFTKASTRLRIVQSGVSSAIKALEKDLGAALFDRSGRQIELTDAGAAFLPKARAALDAARDAREAVQEVRGGIRGTLRIGTLTAIDLIDLPALMADYHRRHPAVHLRLSAAPSGSAGLVDSLTEGKLDVTFVSMPGGAPPGIALRDLADAPLDLVVPAAHPLAARESVRLTDFADEPFVDFPDGYGNRAVTDRAFAAAGLQRSVSIEIVNIATGADFVRHGMGVALLPRFLIPGRSDLRSLPVTDADMRWPLSAATSTLRRPSAAARAFLALLPQHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFD9</accession>
    <name>A0A011AFD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycopeptide antibiotics resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1788"/>
    <dbReference type="HOGENOM" id="CLU_090667_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="19142" checksum="230B30E7A2F6FBC9" modified="2014-06-11" version="1">MRRVIGSAWGGVVAVALLALIPAAGAVVALARWRGGPHRWQHSFAEVGMVVGTAPWLWMILTPRGSGRSVEAVPLVGLIDQLGGAPAVAVEQIGGNLLVFAAFGACAPLRWPLRVRTVAALAGAASVVVELTQYALSIGRVTSVDDVLLNTAGATSAALGVRVALVLVKRRQARVVARTWSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFS1</accession>
    <name>A0A011AFS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173190_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="9466" checksum="71C93F6A4433B72F" modified="2014-06-11" version="1">MLIDCDACGVRGSGCADCVITALVGAPPPGVELTEMPNGVELDDVEENALRALVSAGLDPEFVSITATEPAHDLRHHTDWLGGSHTDRQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFW8</accession>
    <name>A0A011AFW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1981"/>
    <dbReference type="HOGENOM" id="CLU_009834_16_2_11"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="329"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="512"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="697" mass="73858" checksum="00D78AC9351C03F7" modified="2014-06-11" version="1">MTTPEFADEVVTNAFVRYLALPGLDGEIALITLDNGKDHTRPSTFGPGGLASLNSALDEIEAHSPGVKAIAVTGKPFIFAVGADLDGVPRLTDREQALAIGRLGHATFARLRDASVPTFAFVNGAAMGGGIEIGLHCDYRTISSGAAALALPEVFLGLVPGWGGTWLLPNLIGAGNAVTVIVENALNQNKMLKPTQYLELGIGDVLFEPADFLERSLEWAAGVLRGDVEVARPEIDRGQAWDDAVAWGRAVADGKVHGASPAPYRALDLIAAARTSTFEDGTAAEDEALADLIMGDELRAGLYSFDLVQKRAKRPVGVPDRKLARPVTKVGVVGAGLMAGQLALLFARKLEVPVVLTDLDQARLDKGVGYVHGEIDKLLSRKRVSPDRANRLKALVTGSLTKDAFADADFVIEAVFEEIGVKQQVFADVEAVVSPSCVLATNTSSLSVTEMASRLQHPERVVGFHFFNPVAVLPLLEIVRAEQTDDASLATAFSVGKSLGKSCVLVKDAPAFVVNRLLTRFLGEVTRAIDEGTDLLEADRALEPLGLPMSPLLLLQLVGPAIALHVSETLHEAYPSRFYVSENMRTVVGAGKTAFLDWSSGSPVVDPAVAEIYGPRTGGPSADEIRERALAALAEEIRLMLDEGVVAAAQDIDLCMILGAGWPFHLGGITPYLDRVGVAEKVTGQRFLAPGVASLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGZ7</accession>
    <name>A0A011AGZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850519.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2329"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="OrthoDB" id="1322538at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="423" mass="44527" checksum="1BF9A31787BD1217" modified="2014-06-11" version="1">MSGTDSYDTNLVRYSPGFSPRVISRAAGSYVYDVSGAPILDFTSGQMSAVLGHSHPDVVAAVTAAVSNLDHVFSGMLTTPLLEFASRLAGTLPAALSKVLLLTTGAESNEAALKMAKVFTGKYEVVSFDRSWHGMTAGAASLTFSAGRRSLGPAMPGSLVLPTPDPVRSPFRAADGSHDWRTELEYGFQLIDRQSSGSLAACLIEPILSSGGLIELPVGYLARLAELCRERGMLMILDEAQTGLGRTGTMYAFERDGVVPDLLTLSKTLGAGLPVAAVVTSDEIEQVCHARGFLFFTTHVSDPLAASVGLAVLDVIERDGLVARSAALGEHLRERLLGLRERHDVVVDVRGRGLLQGIELGGDSPEKLAAAVTDECLRRGLHVNIVQLPGMGGVMRIAPPLTISDAELDHGTDVLDAAIAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHT7</accession>
    <name>A0A011AHT7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2660"/>
    <dbReference type="HOGENOM" id="CLU_026640_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1338" evidence="1">
        <location>
            <begin position="7"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="447" mass="48872" checksum="898376B24FFBADBD" modified="2014-06-11" version="1">MQQWELRAAFARSLSEMYGTEVPAYTTLLRVSAEVNADVLAERGAEAQRLGSIERVTAERHGAIRVGTPSELRQVGRIFAGFGMHPVGFYDLRDASASSVPVVSTAFRPLEADELARNPFRVFTSVLVADDRRFFDADLQARLETFLGRRELFPARVLELAARAESDGELPDADAAELLAGATACFALSREPIDRAWYDELARISAVAADIGGVTSTHINHLTPRVLDIDELYRRMSGLGITMIDEIQGPPAWDGPDVLLRQTSFRALAEPRRFTDGPGELRVRFGEVEARGVALTAAGRALYDRLLADVDTRRASSGRPRAEVAAEVWREHLPATEEALDRAGLGAFTYRAVPGVPRPGSSDVHEWVRAGAAVREPIVYEDFLPRSAAGIFQSNLTDAGRRDDAHTGAARDAGWMSDALGREVADPIVRNEELTRASLQALNLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI18</accession>
    <name>A0A011AI18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851059.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2731"/>
    <dbReference type="HOGENOM" id="CLU_060721_1_0_11"/>
    <dbReference type="OrthoDB" id="1584529at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046249">
        <property type="entry name" value="DUF6282"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19799">
        <property type="entry name" value="DUF6282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="296" mass="31909" checksum="0651687ED7E62220" modified="2014-06-11" version="1">MIDALPRDFDRLLRGAIDLHVHGYPDLSAGMLDRGDDRQVARLASEYGMAGWVLKSHLWPTTDRARALSVPGFEVHGSITLNPPVGGVEPGVVELAAAHGARVVFLPTWGAAADVERGGYIATRLGRIAPSFGDYAARTAIALCGPDGALTGRTRAVVDTCRALDLALATGHASPRESLAVAEYCAAIGQRLLITHPLHYTRDLREYVALGAFVEFCNAPLVHPDAHLTLRDVHAALETVGPDHAVLTTDVFSRWVPPEPECLRMFVEQLAYLGWTAEQLHTMVSTNPRAFLGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJA8</accession>
    <name>A0A011AJA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851687.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3202"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_0_11"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="79"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="33671" checksum="A8B4428CF8BE0DA9" modified="2014-06-11" version="1">MSEVVLEPAAQDFADATSKPPFIYQLSPVEARKVLDDVQAAPVDAPAVDEHWVLVAAAVGDVRARIVKPQGATGTLPVVLYVHGGGWVLGNAGTHDRLVREFAVGISAAVVFVEYTPSPDAHYPVAIEQAYATARWVVAEGAAHGLDASRMAVAGDSVGGNMTAALAILAKQRGDVTFVQQSMYYPVTDARQNTESYRTFADGPFLTAAGMAWFWDQYAPDHSVRSEITASPNLATPEDLAGLPPAFLLVDEADVLRDEGEAYAAKLRAAGVPVTTVRYDGICHDFMMLNPLKDTHAAQGATAQAIAVLREALGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJY1</accession>
    <name>A0A011AJY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851962.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2552546_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="82" mass="8691" checksum="78EC38413ABEE98B" modified="2014-06-11" version="1">MLESALHAHGAPTTSEQILMRDYPSSGASSGMSGALIRGGLAVNLEQTAASLGAGPIDRAQLAQHHRWRTLRPTCANTDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK22</accession>
    <name>A0A011AK22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1737497_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16537" checksum="765FE811129C3E23" modified="2014-06-11" version="1">MVHRPWRAAWIATLCACVVLTVAVQSELASGPSLDPLYGVAIAALLLWLAWRPRIVLGNDEIALYDYLPPRRRIAWQDIDNVTRNSRWGHRGQLTLNLRDGTELLCPGPSYGLLRVGGGYSDRARAAVETHLATQLDGTARPGRILGQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKB3</accession>
    <name>A0A011AKB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852192.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3555"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27073" checksum="7E13279DB4A28275" modified="2014-06-11" version="1">MIPQYVPGHSLLADRTVVVTAAAGAGIGAAVARKCLEEDARAVVLGDVHKRRLDEAVETLRAEFGASRVDAVLCDVTNEEDVTTLLDAAEPFGGVDVLVNNAGLGGTASILEMTDEQWSRVLDITLTGTMRCTRAVGRRLVAAGRAGVIVNNASVVGWRAQAGQAHYAAAKAGVMALTRCSAIDLAPHGIRVNAVSPSLAMHPFLAKVTTDEALAELTAREAFGRAAEPWEVANVIVFLASAYSSYLTGEVVSVSSQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKF4</accession>
    <name>A0A011AKF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1822167_0_0_11"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="15960" checksum="4A30218DF08684E2" modified="2014-06-11" version="1">MNSVRPSWPLLLRRHRVDHRKADAFLARNLMSAPPVTVGPEASVVEAARLMERHDVKWLPVVDADGSLAGIVSRADLLGLLRRSDADLRAEVREQVLRRPLLLPPNTARDEFDLRGGRRPRRSPALRIRPRTRSLLLSGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALR7</accession>
    <name>A0A011ALR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852908.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4057"/>
    <dbReference type="HOGENOM" id="CLU_059391_0_0_11"/>
    <dbReference type="OrthoDB" id="1419056at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008526">
        <property type="entry name" value="YedI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30503">
        <property type="entry name" value="PTHR30503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05661">
        <property type="entry name" value="DUF808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016660">
        <property type="entry name" value="YedI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32159" checksum="F499AC062EF20B7B" modified="2014-06-11" version="1">MAGGLVALLDDVAVLARTAAASIDDIGAAAAKAGTKAAGVVIDDAAVTPQYVRGLAAKRELPIIKRIAIGSLRNKFLIILPVVLLLSQFLPVLLTPILMVGGAYLCYEGAEKVWHKVAHRGSAHAEEDEGAKDEKTLISGAVRTDLILSAEIMVITLNEVIDQPFWSRLAILAVVALVMTVVVYGAVGLIVKMDDAGLRLAQGPGAVAALGRGMVKAMPIVLTALTIIGTAAMLWVGGHILLVGTDELGLHALYGAVHHVEEAAHDATGALGGVVGWIVNTVFSAILGLIVGALVVVVMTLVAKRRKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALW5</accession>
    <name>A0A011ALW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853024.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4119"/>
    <dbReference type="HOGENOM" id="CLU_013835_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="895" mass="92618" checksum="95AD16659D4A5AD9" modified="2014-06-11" version="1">MRRPSLTMPAVHWPSVRGRARADRGPLSLVAAVVLVVTLLAAALPPLMRATADDAARDAIRRAGPEAAVQVEALWADDYGPNGGRLRDDDLADDVRNVQRVAVDKLDPELRRTLRAPVTVVTSVSLLVTDGSVQRRFQLNYVEDDHGGPAVTWVAGRAPGKTEDGDVETPYAGPPWEAQVGLSEAAAAALKLRPGDHIALKDEQRNPYNVLVSGVFKPVDPGDPAWELVPWVLRPTAGLDGAGSTRLGGLLSPDSLPDGRLALLPDQLRRTVYFRPDPDELTWASAQRLAGAVTALKAGSGSSAQTDTTLKFDTQLDGVLRDVRDQVTAAQAQASVLLIAVLAGAVLVLLLAAELLARRRSAALTAARERGASLPGVALELGLEAAAVTLPAAALGLLLSLVLAGGVAVPGALVVVLAALLAGPASGTLVAARATRDRRVPANRAARRWQERTRQLRRAAVDVAFVAAAAGAVVALRQRGVEGGTLAAAAPALGVLAATMLLLRLMPVGTGLVLRQSLRSRRPLAVFGAARAAATATRALPLLVLVTTTALVTFALTLDATTSRGTGDGAWRTVGADARLDVAPEATGSTARIAARIAAAPGVTGVATAQIDDGVRVIAGGDQTTPSLAVLDAPAFARLLAGNPLPDAPDLTRLRGTGRIPALVRSADGSLRPGMAVQLIRPGTTPLELEAVGEAPAINGEETVIVLDARTAPEPFTPNTVWANGPGAARAMDGAEGRVLTRTAVLQDRRTAPLTAGMVLLDRAAAATLLVLGLLGFALGAAASAPERWVTLARLRTLGLRPRDTHRVAAAELLPPVLVAAVCGPVLGLLLVELTFRALALRSLTGQPADPLTTVPWWLLGALALVLLGALASVVAAESAARRTHRLSTVLRIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG60</accession>
    <name>A0A010YG60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_4_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14045" checksum="7DE5AA128E4E2292" modified="2014-06-11" version="1">MSADPGGAFRLEEVYEPVAAASARIRHRLGALLTESNVAAHVSQDALLVVEELVANVIDHARTPFRLVVQRAGTTLRIQVRDRDRTPARISALDPLAVRGRGLRLVAGIADDWGCDHGEDGKTVWAVMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGH3</accession>
    <name>A0A010YGH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847911.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.360"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_11"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="338" mass="36512" checksum="091758597AA73F16" modified="2014-06-11" version="1">MAAVPGVEVSSLEAYLRKRLPGLLAGPLSVELVAGGRSNLTYLLSDGVGRWVLRRPPLGHVLETAHDMGREYRLLSALHPTDVPVPEPLLLGDAEVIGAPFYVMTFAEGAVLRTRDQLEAFDPVRAAAVADGLIDVLARLHRLDPAAVGLGELGRPVGYLERQLRRWSRQLEASRTRELPELDRLHERLAAELPEHQGAAIVHGDYRLDNVVVDAGTGAVNAVLDWEMATLGDPLTDLASTVMWWDGMQGLDIPVAALPGDVPAFPSGAHLVESYQKLTGADLGDLPWYLGFAHYKMAAIFEGIHYRSLQGMTVGEGFDLLGPLVAPLAERGHDALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGK7</accession>
    <name>A0A010YGK7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569613.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="251"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="467" mass="49692" checksum="C68907065DC1FF98" modified="2014-06-11" version="1">MSLLRLPVRWWRRARLGTRLVALATAAVVVALALSTVVLVVVLKSTLERALDAAARQTGEDVAALVEADNLPNPIPAGGTTVVQVIDPTGRVLAASAGADRLVPMLPKDELALVKRDEERYEPGYRFGVKDVVRVVAVAAGDKTVLVAIPAGEVHESVRVVRVGLLSGYAVLLVLLVVLAWRMVGAALRPVEALRRGAEAIASGGESPRRDTGRLPLPRAQDEIFRLAVTLNTMLGRLDAARARQRAFVADAAHELRSPLASLRTQIEVAEVTSVPAEPADLLADVERLTRLVDDLLLLARMDDAPAGGHPAARRPAEPVEMSVVADVAVARSAGARVPVERVDRPGAASAVVEGDEDALTRVVTNLVENAARYAETRVEVRVGAADDRAWLEVVDDGPGIPAVDRERVFARFTRRDDARDRGSGGAGLGLAIAREIVRHHGGTIELSDASPHGLLATVRIPLSHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGR2</accession>
    <name>A0A010YGR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848123.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.482"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="38198" checksum="A5B850BAFE45FBC9" modified="2014-06-11" version="1">MMAQRQPRRTATLASLAAELGVSRTTVSNAYNRPDQLSPQLRQRVLEAAKRLGYPGPDPLARSLRTRRAGAIGLLLTEALSYAFRDPAAVEFLEGLARECEDAKTGLLLVPAVPGAGTDPALAAAAAVDGFIVYSLPNDDPHLDAALARPVPTVIVDEPLNASGADYVGIDDRAAAAKAGAHLAELGHHKIGIICSRISSQRGPGGQATPERQRSSPYDVVRLRLDGLFDGLQLDREDVPVWECWENTIDSAAAAAKEMLDAYPELTAVACTTDVLALGTMQAVRESGRSVPDDVSVTGFDDIPEAGASGLTTVHQSHAEKGRAAWRLLSRDDRDETPTMRATIPTELRVRQTTSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGW9</accession>
    <name>A0A010YGW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569644.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132132_0_0_11"/>
    <dbReference type="OrthoDB" id="1932679at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457868" evidence="1">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="15769" checksum="CAECC5024AEAAB89" modified="2014-06-11" version="1">MKRAFALALAAASIGLVAACDKPAPYATVASGGDSAGGEATAWCFENGTFNGSAPGDDCKAGPSNAGRIDVRPGATVQVDVPPTVGEDGWTAALASSDGNLAPVSFVRKGTSWIRFTVPTDASGGSTYVLELLALHPGENAEKARGLWRFVLDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH04</accession>
    <name>A0A010YH04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">CryarDRAFT_0596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848297.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.583"/>
    <dbReference type="HOGENOM" id="CLU_092403_0_3_11"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="23420" checksum="5C616578405C63C0" modified="2014-06-11" version="1">MNKSRPKVRLSRALGIPLTPKSVEYFERRPYPPGVHGRRRRQQSDYSLRLREKQRLRFQYDIGEKQLRRVFDEAAKNRAGKTGDVLVSLLERRLDATVLRAGFARTIYQARQFVTHRHITVNGQRVDKPSYRVEEGDVVQVHERSRPMTPFVTAAAGAHVGSGPTAPYLDVSISNLTVRVLRDPVRAEVPVICNEQLVVEFYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHA7</accession>
    <name>A0A010YHA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.689"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="384" mass="41115" checksum="0A33F33F0A961BC0" modified="2014-06-11" version="1">MTSTEPISRANAAFTGRPRMARFGWLFGGIWLFYLVDPAQVAWEQDNVVLRVLGLAALLAFALWYLGIFTFVRSTRFRLWEDEVRRSWTAIGVLVLLAALTVPASGSNALATFVYISAASMMVLPLRYGIGVAVGLLVLALALDAFVPGYSTGAGLIFGIVVSALAIWGVRQMIERNVQLIAAQETVTQLAIAEERARTARDLHDILGHSLTVITVKAELAGRLIRADPDRAEREVADLERLSREALADVRRTVSGYRAVTLAGEIVSARVALDAAGIDAQLPIALDEVPGERRELFGWVVREGVTNVIRHAAARRCVVTVARGCVEVADDGRGAVAASAVSGSELGNGLTGLRERVETAGGTLVVGRSDLGGFLLRVTLGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIT7</accession>
    <name>A0A010YIT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-dependent enzyme of the double-stranded beta helix superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1201"/>
    <dbReference type="HOGENOM" id="CLU_102185_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17957" checksum="A7BE8DB9D8439F74" modified="2014-06-11" version="1">MRPLSGLRLGAVLQRLVATVDWQARVRYDVDDRWYGRLDAGEFAGGVQVEAWLLSWWPGQRTGLHDHGGSSGAFAVVRGCLREDTVHTPAGELPRLRSRSLRASERRVFGPRHLHEVVNDGVEPAVSIHVYAPRLTTMTRYRWTDFGPEVATVEKAGADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJA7</accession>
    <name>A0A010YJA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849113.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1334"/>
    <dbReference type="HOGENOM" id="CLU_1123813_0_0_11"/>
    <dbReference type="OrthoDB" id="1445370at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26327" checksum="8CDAEF15F0B1B88D" modified="2014-06-11" version="1">MRTLGVDLAAEAATTALATIDWAPSGARVHHVQVSITDDVLVDAVRGATRTGIDCPLGWPTEFVRFLVAWSAGTFEPPVRTDKAWRRRLAYRRTDEVVRERLGLVPLSVAADRIAHPALRCAGILARLAADGVRVDRVVVEAYPAGSLKCWGLPHRRYKGTANAPARHALVDELLARAPWLDLGPHEPLCRASDHALDAVLAGLTARAAALGLTHPPLPEDAAAAAKEGWIALPTGPLDELDPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJL0</accession>
    <name>A0A010YJL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">CryarDRAFT_1499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849295.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1471"/>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_11"/>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="54"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25026" checksum="76633FA3AA575335" modified="2014-06-11" version="1">MALDLIALLPEPWQAVLTPFLDRDRVAELGRFVEREYAEQTVYPPVDDLFAAYRLCAPDDVRVLLLGQDPYHGPNQAHGLCFSVREGNRVPPSLRNVFKEMAADVGTEMPKSGELTAWGQQGILLLNSVLTVRGGKPGSHANKGWEEFTDATIRAVNTLDHRVVYLLWGSYARKKAALVTNPEHVVLEAGHPSPMNPRGFLGSRPFSATNKALTDAGLPEITWELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMB5</accession>
    <name>A0A010YMB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711184_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="41558" checksum="E5FE263C2F5B61C8" modified="2014-06-11" version="1">MSTGLLGDTRRDVARRHSVRRQHTMRPGMLPDTRRNVAGPHAARAHAARAYVAGAHVAGARVTRTHVTGTPATGRHISRAHIAGRHVARRHIAGRHTAGAHVARGDSAVRRGATGWNGAGGWAVGRHDPVCTRGLTDTRRYLVRWEHGVGAGRLVDDPVRTGRPADRTGVHRRLAVVRPGAGRHDPRGEGSWTARGCRLRPDRPAALCRSGLTGSGWRPGRALRPVLRRLGIGRVGETTLLRSTVLERARLHPTRCGPALTRRALLGYALLGYALLGNALLGNALLGNALLGNALLGPTRRGNTLLRPTRLSRPRLRSARAEDAWMGRARFEYARLGHCGVGRAGLGGSRMRARRPTTEPRRCRAGGGRTPGGCLGILTGHLGRGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMH1</accession>
    <name>A0A010YMH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850742.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2500"/>
    <dbReference type="HOGENOM" id="CLU_080997_0_0_11"/>
    <dbReference type="OrthoDB" id="1518967at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="29122" checksum="FA9015433A79A4AA" modified="2014-06-11" version="1">MTGPAEALERRIDDLRAAVRRAVTAGERARARTLRTELHRTEREWESALEALAPDSEPAGPAPAPAALLPLREQVHQALTMLGAPAAPKLIVQVHEAFSTGGLTSARLTSLRRDEERSFRSAPQMRPYYLCAALTADLLAPARGLLAVSTWPMSARVIGPLSPRVDFLTAAARLAEHVQRLADPGPAARRLLWRFAANIPGAGNVPGVAAGPDQTSAPAVAAAALAELELHRDTDERQRAEAARRARDRLDEAQQLFGTKFGVVGRNARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNN6</accession>
    <name>A0A010YNN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2847"/>
    <dbReference type="HOGENOM" id="CLU_027634_7_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="30619" checksum="6A8F72AF508449AF" modified="2014-06-11" version="1">MYSLESALVDVAIDVPALPERGGDVVATGTRIHAGGGFNLASAVARQGVRCVYAAPVGAGRYGEVIRAALSAEGVTATALPRTHGDSGFAVALVEPDGERTFVTSAGVESALTVEDLAKIEPAPGDAVVASGYDLAYPDTGPVLAGWLPTLPAGVLVALDPGPLVLEVPAERWARVVGRVDLLTVNQREARLLSGSSASGVSLLEAVRGLRDAPGALVVVREGADGCVATGGALGSRVVSVPAPKVPAVDTTGAGDIHTGVLLARLVSGSPVDEALADAVRAAAIAVRKPGSATGPTRAEMDHPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP28</accession>
    <name>A0A010YP28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851437.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3019"/>
    <dbReference type="HOGENOM" id="CLU_006850_0_2_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="886"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="963" mass="102768" checksum="6D75EE987D746FA5" modified="2014-06-11" version="1">MGMRSEACLCPVLIGRGGLVEHAGRRTGEMLDGAGGMLFLAGEAGIGKTRLLAEIVERAAARGARIARAGAFPRDAEVAGGLLLGLTTSLGPLGHPAGALAERFRGAVTGGSADGTRWRRLLVHDAADALVAADEPLVIALEDLHWADELSLDVLDRAAPRLRTAPVLVVATYRSDELFPHSALRTWRTRLLTGRAAEELRLPRLDRDATARMVAAILGSVPGDRSAAALFERSDGIPLHVEELLAAAGADGAGPCQSTAPTVRLPDTLADAVLGRSRELSEDSLAVAAAAATIGRRFDVDLLTAVTGTSPEHVDAALQVLRDRFFVSPGADGTGYDFRHALIRDALYDALPPHRRRFLHARVADAARDAGFGDAFLSDHYERAHQHRAAFTSALAAARHATAMSAHVEATALYRRARRTMPADTPDDVRGDLLTALSIELIAIDDVPGAEATLTDAYAHRLAQDETIQAAKLVPALVTARHRLGADLGYRVGLLREGLRLIDERTDTTAEHVRARLLAAMSAVYMFDRRLDESLTHGEAARALATALGDDRTRWSVDATIAPVLLFAGRMDEGWELADSTIAETLAADAEPEASRAYQMVGSSAAVLVEYDAADRYLDAGIAYAERTEQFGDRNYMLAMRARVQWATGAWADARPNAERALADFGDTVLTRILALQVLGFLAIGRGDGAAAREHLDAAYGVGTELREVQRLSPTIWGLAELALRGGDTVAARARCEEGLAASEQVGDAAYLFPFVVTGVRAYLADNDPTRAHVFLGRCATLLEKRSIPGTLPALDHAEGLLHLHEGQTGKARVALEAAGAEWDRRRQFWEGTQALLDQARCAHRSRRPADATALARTARDRATSAGAVVLTGAADDLLAAIGTREPSGPPGLTPREIEVARHIAAGATNREIATALTISPKTVAAHVEHILTKLRATRRTQIASWVHVTAARSDADPPDRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP84</accession>
    <name>A0A010YP84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851510.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2733248_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7493" checksum="DCD558804A0FC8C6" modified="2014-06-11" version="1">MPPSEYSAALLQSKPAAIRDGCRSHFSASVFNASPQDGHLLGDPQPLALQQRHSPAVLAAPSASTREKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPF5</accession>
    <name>A0A010YPF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308400_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="210" mass="21204" checksum="534E7FA16D7C888A" modified="2014-06-11" version="1">MTRPRTTALVAVAICAIGVLYTAAMALTGAVLSFGWVIQSAIHLGEMLAVVALGRAGAAGGSRTARAGLGAAALGQAVLAAAEVIWVDSPGLGEVLFGVGPILTAVGLIGAGVVIARRWQRPAWQRFAPLALGIYIVAVMTPVLIGSGGPPAPAALWALVAWDALWETIAVSALVRPARHARSPKGPGVGTVDEHVARATHGTFHPPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPJ1</accession>
    <name>A0A010YPJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3208"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="863"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="930" mass="98883" checksum="617678C8EBDF24E0" modified="2014-06-11" version="1">MVERIRRATVGAHNESDLPGRAAELGVFRTLFDDARAGTSSALVVQGDPGIGKTALAQAALARFTDEIRVERTVGVESEMELPYAGLHQLLAGMLDRAESLPAPQRDALETALGFRTGAAPSSFLIGLAVLGLLTEVAADGPVCCLIDDTQWLDEASRQALAFSARRLGSEGIALVFVMRTVDASFRGLPGLAVTGLNDDDARRLLKQLLPGQIDTRVRDRLVAEARGNPLALRELPSALGPTEMAGGYTVAATAPLASRIEKSLLDQLSDLPPAARRVLLVAAADPTGDPHLLRLAVRALSLSSDAIDVAEHSGALTVGARVEFRHPLVRSAIYRDAPPPDRRQAHAALAEATPVENDPDRRAWHRGHAAVEPDEDIADALDRSAVRARGRGGVAAAAAFLERAAALSPLPGDRARRLLAAAQAKLDAGAPDAAETLLSVLPTDALDPLGAARVDLLRAQVDWARRGSPDIARDILAVARRLSPLDPALARSAYYDALFAAIFAGGLTDLDADGDVYPWSDVCRVVYDATDPDSTNPVDLLLRGQALIGLGARVEAIPVLRSAIAGLLDAPEALIPPQTAGLDGVAAIDVWDADALLALNERHIELARADGLLTVLPMVLSLAGSALLVQGRLDDAQLIVDEIDVIKEAIGHPFPRHQRLLIAAWRGDQAAVEALAAELRRTAIAHGDGSALSIANFAEAILANGTGDAAGALRAGREEMGHIRQVTYTSRILAEVIEAAVRVGDRATADRALADLTDLTAPIGGDWALGMLAAARAQLAGDEAEKYYSEAIDRYRRGGLAVYEGRARLAYGEWLRRQRRRVDARSELRVAHDLLSSRGAAAFAARAQRELEATGETARSRLVDPGDALTVQEANVAHLVVDGLTNREIAARLFLSVRTVEYHLRKVFLKRGVQSRRDLAEALRSEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQF8</accession>
    <name>A0A010YQF8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119287_0_0_11"/>
    <dbReference type="OrthoDB" id="1241950at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="2">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="19671" checksum="7C37B2CAC67BE46E" modified="2014-06-11" version="1">MLGGVGSREPRDAPPGERWDLAQANIARLRQPLGDPRVAEFVAALDAVYRLAEHSPGFVWRCATDEGHPGVDPTDPLTVVNVSTWRSYQALHEFTYRSRHGHFVRRRREWFDSLPGPTTVLWWAPANAQPTIPEALARLSVLRRYGPQPPAFGIRQRFHPDGRPERPWSGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQS8</accession>
    <name>A0A010YQS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class putative F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852427.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3718"/>
    <dbReference type="HOGENOM" id="CLU_123922_3_1_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="14124" checksum="5204E482F66FB58F" modified="2014-06-11" version="1">MPLPDDLLEVLRGKAICFVTTLMPDGSPQISQTWADTDGKHVLINTVDTHQKARNIGRDPRVAIGIADPAAPLRSWALRGTVVAAETSGARQNLEELSQKYIGRPYPNYGGGEQQRVLLTIEVDRVHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRJ4</accession>
    <name>A0A010YRJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852777.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3989"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19322" checksum="6E84E3067323D878" modified="2014-06-11" version="1">MVRSDARENRVRILAAAREAFAGDGDPSMNQIAQRAGVGAGTLYRNFPTREALVLAVYQHELERILETVPALLAAHPPIEALQRWTLDLVDAMRQKHGLGDALSPGAHQAIAEQSYGPVIAAITQLLDAGKRTGVVRVDADPADFLQFTAALWRAATEPEDRAPRMLALLLDGLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV80</accession>
    <name>A0A010YV80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA/RNA helicase, superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725636.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.77"/>
    <dbReference type="HOGENOM" id="CLU_003041_27_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="258"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="56546" checksum="EA87202FF4FAC3A8" modified="2014-06-11" version="1">MPDFASEDAILEKLEADVAEAPADQTPAAVRFAELGLPSAVVTALERQGMTDAFPIQSATIPEVLAGRDVLGRGSTGSGKTLAFGLPLIAKLAGARVRPGRPLGLVLVPTRELALQVTDALAPLGRTVGVRVRPIVGGAAMSRQLEDLRRGVHVVVATPGRLEDHIRRGSAVLDDVEITAIDEADQMADMGFLPVVRGLLDQVRPDGQRLLFSATLDNDVDTIVREYLKDPVTHSLAPSTASVDTMEHHMLHVIHADKVRVAAELVKSTGRTIMFVKTQAGADRLAEQLTERGIFAEPLHGGRTQGQRNRVLTNFKNGRSPVLVATDVAARGVHVDGVGLVVHYDPPTDPKSYLHRAGRTARAGASGVVATLVAPYSRRSAHRLAKLAGINPTRSTIAPEAPLPSVLTDALPPAPPPPTAEELAAAETRRRRDREFDADRGRGGFRRGPRSGSGERGYRGGPRRSDGPRWSDRSERTDRGERTDRGDRPQRSERGGSDNYRAGRPRWTPEQRSARHREDRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVW2</accession>
    <name>A0A010YVW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.271"/>
    <dbReference type="HOGENOM" id="CLU_040940_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="25661" checksum="DBD54AAC19C7EFC4" modified="2014-06-11" version="1">MSFPDVGPDTPGHPEPGAETLPSWLRRLVDALPRVRSEEISRFVPPPDGSGRPSAVLILFGEGPDGPDVLLLQRAATLRKHAGQPAFPGGATDPGDDGPVGTALREANEEVGLDPASVHVIGELPPVLIPVSGFVVTGVLGWWERPHAVGPADPAEVATVARVPIADLVDPANRFRVRHPSGIAGPGFDVCDMFVWGFTAGLISFVLELGGWAEPWNRNSMRDLPAEDLALAMRTRPPDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWR7</accession>
    <name>A0A010YWR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_0644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725651.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.630"/>
    <dbReference type="HOGENOM" id="CLU_015488_2_1_11"/>
    <dbReference type="OrthoDB" id="1331351at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="33876" checksum="119F09D9C6C9743D" modified="2014-06-11" version="1">MRRHRIVLLATAVVVMLGAGVTTLLLRGGSEPERRSISVPKLQGSLYDDGGQAAAWVSANQSDPDATVISEKIASVPQAVWITGGDDAAKAGTQVTRTVAAAKAAGEVPALVAYAIPDRDCGGAAAGGAPDGTAYRAWIDAVATGLGPDPSIVVLEPDALAQVDCLDAAKRSERNELITYAARTITEKAPRAQVYYDAGNSKWKPAAEMAERLRAAGADDYGSGISLNVSNFRPTKDEVGYGKRILDGLGVDGKKIVVDTSRNGAGAATDNEWCDPAGRKLGQTPTLDTGDEDVAAFLWVKRPGEADGCAANAGTFVPDLATALAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX89</accession>
    <name>A0A010YX89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfite reductase, beta subunit (Hemoprotein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848542.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.806"/>
    <dbReference type="HOGENOM" id="CLU_015667_0_1_11"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="39121" checksum="5F384FD72E1E1A90" modified="2014-06-11" version="1">MPTAVPFRQAADSCPGALQVHEAADGGLARVRIPGGVVSLTQWRALRDFAPLELTSRANLQIRGVTDPDALASRLADAGLLPSATHERVRNVVASPLGGLGAVVSALDRALCASPELADLPGRFLFAIDTDRDVVSLRADVTVLLGSEPVPVLLAGVDSGLRVRADQAVPALIAAARCFLLERVAQASKAWRLSELDDAVARVAGRMRSALACDLVEPSALPSHRGADPIGVLAGALGVVVPLGRLTATQMDAIAGVARGEIIVTPWRGVVLPGVGAEALTPLAEAGLVTDPASAWASASACTGLPGCAKSRADVRADAGTALLHPGELLPVHFAGCERRCGHPAGVHVDVLATADGYQVDGEPVGVDELPAAVAAARRNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXA4</accession>
    <name>A0A010YXA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dinucleotide-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848575.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.828"/>
    <dbReference type="HOGENOM" id="CLU_076368_0_2_11"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="22570" checksum="25AF34348BD19221" modified="2014-06-11" version="1">MTTVGFIGSGHIGGTVARLAVAAGYDVVVSNSRGPDTLADLVAELGPKARAATASEAAAAGDLVVVSVPFGRYQQVPAEPLAGKPVLDTNNYYPARDGEFPTLDDDSTTASELLQEHLAGAHVVKVFNNIYWESLRSLARPNGAPDRSALAIAGDDADAKAAVTAFLDTIGYDAVDAGPLAEGRRYQPGTPAYGGIYAGSSLQEAVTGPADKVRKALADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXZ7</accession>
    <name>A0A010YXZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1119"/>
    <dbReference type="HOGENOM" id="CLU_044590_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="32135" checksum="B0C540F786930ADD" modified="2014-06-11" version="1">MALIDTELPALCRELGIPGFADVHVHFMPERVLAKVWAYFDALDVLEWPIEYRLDETERLERLGELGVIRHTALLYPHKPAMAAWLNEWGLSFAKDAPNCVPTGTFFPEPGAAEYVRVALESGVRAFKAHVQVGAYDPRDPLLDEVWGRLADAGVPVVCHCGSGPMPGRFTGPGPIGEVLARHPSLTLVVAHLGQPEYAEFLALAEAYPNVHLDTTMTFTDFVERIAPFPAALRPRLRDLAHRVVLGSDFPNIPYPYAHQVESLIRLDLGDDWLRAVLHDNGLRLLSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY87</accession>
    <name>A0A010YY87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine/acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1220"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="47313" checksum="1C3F83D7456B8075" modified="2014-06-11" version="1">MTVQPDQTTDRVSELAAAVTSGGFPWASKNAMLEASETYWNPGKTRFWTDEGVPLVIDRREGYHLHDVDGHTLIDVHLNGGTYNLGHRNPEVVAAVTKATERFDVGNHHFPSIARTALAEALVRTAPPGLTKVIYGSGGGEAIDIAIKSARHATKRRKIVSIVKAYHGHTGLAVGTGDDRFSRMFLADQPADFPHVEFNDLAAMADALRGDDVAAVIMETIPATYGFPMPAPGYLAAVKRLCEDHGTLYIADEVQTGLGRTGELWAITKHSVEPDILVTGKGLSGGLYPITAVLASDRAAAWLTEDGFGHISTFGGAELGCVAALTTLDLTLRASTRDNVAALSELFASGLGRIRDEFPDWLVGVRKDGLVMGLEFAHPEGAKYVMRRLYQGGVWAIFSTLDPRVLQYKPGLLVTAELAADILERTRTAVRLSRDDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYE3</accession>
    <name>A0A010YYE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849041.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084200_0_0_11"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="22686" checksum="EF0833BB29835900" modified="2014-06-11" version="1">MAVVLLVRHGQASFGAAEYDELSELGREQSRIVGVNLAAQDVRVDRAVSGGLRRQRDTAELCLTAAGRATDVRVDPRFDEYDHLGLAAQLHDGPVPTSSRDFQAVLDVALEQWVSGAIVPEGMPAWGEFSDRAWAGLDEFVTALGRGGSGVVFTSGGVIAAICARLLGLTPAGFVALHRVVINGGITKVVAGRGGTALISFNEHSHLPAAQVTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYJ2</accession>
    <name>A0A010YYJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1309"/>
    <dbReference type="HOGENOM" id="CLU_660077_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458942" evidence="2">
        <location>
            <begin position="35"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="40652" checksum="21E888658B58D5B9" modified="2014-06-11" version="1">MRKRAGRSRWAIGAAVGGTAVALTAAAMVGVSSASMDSNADPAAASADKIVCPDVASQLAVVPSAAQAEVAQNVVLLEMQISEAQTRLETSNGEGGANFVQNAILGPLADKRQATIQRIETAIGRKADKPDLNAEELATCEVAAADAADAPSADPANDPAADDAAADDAAADDAAADGNAAADGKHEKKGKHGKGKDDAAAADDAAAADDAAAADDAAAEDAAAADDAAAADDAADAADAGDGGAIQCGAAADYVDAAEIDAADVPDEAADVVDEGLEEIAAKEAAAEKEMAKAKHAGRKYVQENILNPLEVQRVGLLARMGLAVDKYNDAAVKEGAKADAADDAAAADDAAAADDAAAAADDAAAADDAAAKDDAAAEDDAAADDADAAADDDAANQALEDALELIIAAAGCSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYL1</accession>
    <name>A0A010YYL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849107.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1332"/>
    <dbReference type="HOGENOM" id="CLU_030226_0_0_11"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457750" evidence="1">
        <location>
            <begin position="28"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="40"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="354" mass="38104" checksum="6A3FDE39F5F5074D" modified="2014-06-11" version="1">MRISRPGACSALALTVAATVVAGFPAAAIAQPRHGTSSTPAVIAHRGASGYRPEHTLAAYELAIEQGADYVEPDLVITKDGVLVARHENEIGGTTDVSGHPEYAGRKTTKTIDGKAVTGWFTEDFTLRELKTLRAIERLPAVRPANTAYDGTFAVPTLQEIIDLVKRQHRTVGIYPETKHPTYFRSIGKPLEEPLVKILKRTHPRKVVIQSFETGNLRRLNRMIDVPLAQLVDATGGPFGEPRTYDDLVTPAGLRTVSTYADGIGLNTARVITASGTPTTIVADAHRRGLVVHVWTVRAENQFLPASFRDGTDPNAHGDVEGWIALLLAQRVDGFFTDLPDVGRAAVDVGAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYM5</accession>
    <name>A0A010YYM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725672.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1351"/>
    <dbReference type="HOGENOM" id="CLU_051796_0_0_11"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="49"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="36714" checksum="BA1F8452DBDFB703" modified="2014-06-11" version="1">MAISTEAQAWTTDVLGEPYEQRTIPLGRDDQGEVVATLIRRRAEQPTGRAVLHVHGFVDYFFQTHLADRLVEEGFDFYAIDLRKYGRSLRPHQTPYFCRSLTEYFADLDAAVDIIRGEDAHETVLVHAHSTGGLIAPLWAHRHRTESLVDGIALNSPFFDMNQPRMLRNAIDYFAAPLGTFRPYQVMPAPSSNYYGRSLHRDHNGEWDYDLAWKPMSGVQIHAGWLRAIRNGHRRIEAGLAIEVPVFVACSTATFRSSRWDESVLRTDAVLDVEHIASRAHRLGRQVTLVRIENGVHDLALSAAPVRDRYLEELLRWVEAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0H0</accession>
    <name>A0A010Z0H0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850077.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2008"/>
    <dbReference type="HOGENOM" id="CLU_025854_0_2_11"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="31380" checksum="49209181FC14552A" modified="2014-06-11" version="1">MSLSAHEFQFVSSLVRREASIVLEPGKEYLVEARLLPLARKAGLASVTEFLLRAQSPSGRQDRDSIVDALTTNETSWFRDREPFTAMTELVIPNVVKSRGPSRHLRVWSAASSSGQEPYTLAILLKENLPPGWTYEILGTDISTEMLARAERGRYSQLEVNRGLPAPLLVKHFTRAGAEWEVAAPIKKAVSFKRLNLAAPFPPMPAFDVVFLRNVLIYFDVETKRGVLKRIRNLLKPDGWLFLGAAETTMGIDDGFERVVTGRTSAYRPRTGISAPVGVTGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2L7</accession>
    <name>A0A010Z2L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_2787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851082.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2749"/>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_11"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="428" mass="46999" checksum="5DE76EF65F53FBEB" modified="2014-06-11" version="1">MVHTTAEYDVIGVGFGPSNLALAVALTESAEAPSALFLERQASFGWHRGMLLDDATMQVSFLKDLVTLRNPSSRFSFLNYLHERGRLVDFINHKTLFPLRVEFHDYLEWAARQVDDLVRYGHEVIGVRRVADDLVEVLVDTGTGTIVHRARNLVLATGLQPSLPPGVVADERIWHSRDLLHRVAALGAEPPKRIVVVGAGQSAAEVTAFLHDRYADAEVWAVYSRFGYSPADDSSFANRIFDPSAVDDFYDAPGWVKDQLLTYHANTNYSVVDSELIAELYRRSYREQVLGRPRLRMMNVSRLVGAVSTPDGVRVTVEALATGEQTVLDADILVCATGYDPVEPATLLGELNAFCRRDAAGRLEVDRDYRVATDDGLGVGIYLQGGTEHSHGISSSLLSNGAVRAAEILDAIRTRADAPANARPVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2X2</accession>
    <name>A0A010Z2X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase, carboxyltransferase component (Subunits alpha and beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851181.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2830"/>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_11"/>
    <dbReference type="OrthoDB" id="123223at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="53097" checksum="7F32E8FC806684B9" modified="2014-06-11" version="1">MTAAHQELVAELHEKLATTARGGSEGARTRHVERGKLLPRDRVDTLLDPGSPFLELSPLAANGLYGDESPGAGLITGVGRVSGRECVVVANDATVKGGTYYPMTVKKHLRAQEIALDNHLPCVYLVDSGGAFLPRQDEVFPDREHFGRIFYNQATLSARGIPQIAAVLGSCTAGGAYVPAMADETVIVREQGTIFLGGPPLVKAATGEVVSAEDLGGGELHAKTSGVVDHLADDDTDALRIVRNIVGTLAPPAAAPWERRPAGKAADQRALYDIVPTDPRIPYDVHAVIGTLVDGGEFSEFKARYGPTLVTGFAHLHGHPVGIVANNGVLFAESALKGAHFIELCDQRGIPLLFLQNITGFMVGREYEAGGIAKHGAKMVTAVACARVPKLTVVIGGSFGAGNYAMCGRAYSPRFLFLWPNARISVMGGEQAAQVLGTVGTVDPDEIRAQYETQGNPYYATARLWDDGVIDPARTRDVLGLALGVCSRAPLAPVSYGIFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4S9</accession>
    <name>A0A010Z4S9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852073.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3486"/>
    <dbReference type="HOGENOM" id="CLU_082760_3_1_11"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="21331" checksum="E7189D2DFC62CA6E" modified="2014-06-11" version="1">MAAGDHGLGGRLPLVDPAALTPAQQPFYDAAMEEQYPWSQRAGFQFVTEDRRLIGPYNAFLRRPEVSEKFQEFAKAASRHSSLSPQLCEVVILAVGSAWGSDYEVYAHRILAQVAGVTADDAAAMAAGRSPGKLGREAELVFALVRQLTVEHHVDRTLYDEARSVFGEQGLVDIAALTGVYLTVSSVLNLFAVPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5H4</accession>
    <name>A0A010Z5H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852516.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_11"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="45986" checksum="3E0EB3E2E9018837" modified="2014-06-11" version="1">MGESTFAVPVAPGRQPLVGHMPALARDVVGFFESLRDVGDVVEVRFGRTPVYVITDAELVHRAMAADSGDFVQGKLYDKLARVAGGGVACTDGPGHLDQRRALLPAFRPARNAEFADLFREQALELSRSWRPGQPVNLLRDMYRLTTRTTARALLGGDLDDADTNWLADNIPFVFSIFALQTLSPSDLLEHLPTATNRRYAAVRERLRAIVDDVVGRSSGDGDDIVSTLRRAHHGGDAADEVATILITAIEPTATVIAWLFYYLARNPAVEARVHDEPAYLRPVITEVLRLRHPIYFVMRRTVREVRLGSWPLPAGADVLWSNAALHRDPAAFPDPHVFDPDRWASGEPPHRHYLPFGGGAHKCLGHRFATSEIDVVVSTITERWRLVLDPDVEIPLGVLHPDEMPVSVVARDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5I4</accession>
    <name>A0A010Z5I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MccF-like protein (Microcin C7 resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852523.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3770"/>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_11"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="32390" checksum="D5B85D9E54B573D1" modified="2014-06-11" version="1">MRDIRPPRLRPGDRVAVVAPSGPVPADRLDRGCDRLRKAGFEVTLGAHVLARHGYLAGTDAQRAADLTSAWCDDDVRAVLCARGGYGALRLLDHLDPARFAAARPKPLLGSSDVTVLHRWLARHAPVTTLYGPMVAGRALGSDALGPRWAEQLISVLTAPDRSRLLHSPHARELVAGLATGPVVGGNLNLLAALLGTTEVGSADGCVVLLEDVNKESHRLDRLFTQLLRARWFDGAVGVVVGSWQNCGEDADAILLERLGPLGIPVLTGFDVGHGPRQLTVPLGVPAVLDTASRSLHYPRPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5J7</accession>
    <name>A0A010Z5J7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852541.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3787"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="23441" checksum="6CDB5EE00F4DFE45" modified="2014-06-11" version="1">MIRVLIADDEAMIRAGVRAVLTTDPTIEVVAEAADGRDAVELVRRHRPAVAVLDIRMPKVNGIDAAAEIRRAVPATGVLMLTTFGEDDYILRALGGGAAGFLVKSGEPEELIRAVHAVAEGAAYLSPKVAARVVAHLAATGVGAPAGRRSAARERVAALTTREREVLVFLGGGLSNGQIARRLHVVEGTIKAHVSSILARLGVDNRAAAAVVAHEAGIVPAAQSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5P3</accession>
    <name>A0A010Z5P3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852597.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3830"/>
    <dbReference type="HOGENOM" id="CLU_083287_7_1_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="156" mass="17145" checksum="865EC2A090F1A19B" modified="2014-06-11" version="1">MSSRSGADLALLLLGSYRNLVDEVTRELAARGYPDSRPSHEYAMRAIRAGADNASELGRRLAITKQAAAKTIAVLLDRGYVTAEAHPDDARRKHVQITEHGLALMRAGEAIFDEVRARWADRLGVEELERLEAQLAQFVGDSPIRLDAPGWAAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5U0</accession>
    <name>A0A010Z5U0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852635.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3867"/>
    <dbReference type="HOGENOM" id="CLU_000604_70_1_11"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="84"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="310"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="633" mass="66002" checksum="9A0F208891287E4A" modified="2014-06-11" version="1">MSTGVESRPVRGGLVRAVLRTPRGAVAVVFLAVLTAACVCAPLLTRFGPLDQHIDAVRGLPSGTYWLGTDVLGRDLLSRILFGGRSSLLGVVEAVVAHLLVAVPAGLVAGYFGGLVDRALMRLAELLMSIPAIMILLAVLAIFGNSLPVAMIALGVLSSGGLMRLVRGAALVAREELYVTAAELMGLSRVQVMLRHVLGRCRGVIIVQTSLFAAIALGVQTGLTFLGLGPQPPEPTWGGMVAEAASVFSQAPWMLVPPGTVIALTVLAFGVLGDVVRDATSERQSAAGAGRATRRAGRTGNAAAPSDALLSVQGLSVAVGGDTPLRLLDDVTFEIAAGEVVGLVGESGSGKSMTARALIGLLPTNCLVESGHVVFDGTDLAELDEAAYRAVRGRQIAMISQEPMGALDPSFRIGSLVGEVVRTVEGRRGRAVRDRVVELLTMVEIPDAADVARRYPHQISGGMAQRVAIAMALAGGPRLLIADEPTTALDVTVQAEILDLLRRLQQENGMAVLLVSHNLGVIADMCSKVLVLYAGQVVEQAAVDALFAAPAHPYAAALLASSPEKAGIGQPIRAIPGTVPAPEDWPTGCRFANRCELVEPACRAEAIPLVDVGADHHSRCIRIPVLLEQEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z652</accession>
    <name>A0A010Z652_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3940"/>
    <dbReference type="HOGENOM" id="CLU_010756_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="945" mass="99899" checksum="A32E807A8BBF5245" modified="2014-06-11" version="1">MLHVTAQMTDVAGALTRAGLEFRDDAATKAMYSTDASLYRIPPLAVVRPRHVDEVAATLEVARALGVPLTSRGGGTSIAGNAIGRGIVVDFSRHLGRVLDIDAGSRRAVVEPGTVHAVLQKAALPLGVRFGPDPSSHPRCTIGGMIGNNACGNRALGYGRTSDNVLAMTHLLANGQTLRTGYDAAGAPTVDGPAQLLTDLRAATGRHLASARTEFDRFGRQLSGYAVQHLLPERFDVGQALIGSEGTLGVLTEATVRLVTDPAHRILVAIGFRDIVAAGEAAPTVVTFSPTACEGMDERLVDVLRNRRGDAAVPPLPRGGAWLFVEIAGDDRADVLDRSRRLAAADLGVESLLVEEPAAQARLWRIREDGAGLAGRAPSGRPAWPGLEDAAVPPERLGAYLARFDGLVAEYGMTAAPYGHFGDGCMHVRLDFPLDRADGTHVLRAFLTAAAGLVAEFGGSISGEHGDGRARGELLSLMYSPDAIALFGAVKHAFDPGDLLNPGVLVDPDPFDADVRPAGVSYRRELAFLYQHDRGDLAEAVHRCTGVGKCRADNSASGGVMCPSYLATREEKDSTRGRARVLQDVVRGELDWRAPGVHDALDLCLSCKGCASDCPTGIDMATYKSEALHQSYRGRVRPRSHYTLGWLPRWARLAGRSALTARVANAATRLPGLKRLSLALAGVDARRSVPEFASTSFRRWWSRQRPVAGTRTPVLLFVDSFSDAFSPEAARAVVDVLRDAGYEPTLPDPGTCCGLTWITTGQLDAAKRILGRTVSRFAAAARDGIPIVGVEPSCTAVLRSDALELLGSADAEAVAGATVTLAELLDRTPGWTPPDLTGTTVVAQPHCHHHAVLGWQADARLLARTGATVRTLSGCCGLAGNFGVELGHYDVSVAVAGQQLLPALDADPDAVVLADGFSCRTQVADLRDRPSVHLAQLLAPPRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6P6</accession>
    <name>A0A010Z6P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K+ transport system, NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853112.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4164"/>
    <dbReference type="HOGENOM" id="CLU_046525_3_1_11"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="23944" checksum="9EB0E34348203724" modified="2014-06-11" version="1">MAERKKSKTEAGSDNVVVIGLGRFGGQVAESLLFLGHEVMGVDENTRIVQQWSDRLTHVVQADSTDEDALTQVGIREFSRAVVGIGTDIEASVLTVLTLSELGMPEIWAKAISVKHGKILTSVGADHVIYPEATMGERVARLIASRLLDLVDLGDGDAIATVRPPEDAIGRTITDLGVRTTYGVTIVGIKTPGAGIEWATPQTVVPDGCALIVSGSIDQVQRFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKD5</accession>
    <name>A0A010ZKD5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.129"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="104" mass="11400" checksum="33E7525CD31AB8A3" modified="2014-06-11" version="1">MDAVTDETWTSEVLTSDVPVLVDFWADWCGPCHRLRPTLEALAEEWAGRVRVVSLDIDANPNVARDYGILSAPTLTLFRGGEPVRTVVGAQPKSRLVAQLEPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKY7</accession>
    <name>A0A010ZKY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase/secretion neighborhood ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847844.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.306"/>
    <dbReference type="HOGENOM" id="CLU_005379_8_0_11"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="64"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="394" mass="40960" checksum="D8C45DA19F214428" modified="2014-06-11" version="1">MTASATDPEALAERVRSRLITLGHPPTPAAVATAVRAEYGSPIGDRTLFTLTARLHAELVGAGPLTALLAEPTVTDVLVNGPQEVWVDRGAGLQRVHCDLGDDTAVRRLAQRLAAACGRRLDDASPFVDAKLPDGTRLHAALPPVAATAVHLSLRTFRPQGFTVDDLVAAGTFTPESAAIARAVLAARLAFLVSGGTGSGKTTLLSALLGEVPADERLVIVEDATELRPVHPHVVSLEARPANAEGAGEIVVRTLVREALRMRPDRIVVGECRGPEIAELLAALNTGHDGGAGTLHANTPDAVPARIEALGLLAGLSRDAVHAQLAGALHVVFHVVRRMPGGGRPGLRMVTAIGVFGVGPDGRVVVRPAWRRDGGPTPGLASLHALLDARGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLF2</accession>
    <name>A0A010ZLF2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561084_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="293"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="486" mass="53838" checksum="3BEC771D3318C4AF" modified="2014-06-11" version="1">MAKPGKTEAAIEYCYRYSQNYDVIWWFDSTDVRNTFKECELKCEEAATRIGGPRSLFVFDCPEGDTRVDGLLALLNGDAPLALRVATELPAAWSGPAVRLGRLARSESAVLLGQSDPLLDPEDADALGSLLGDEPFRIAQLNAMILAGAVDAEVALRLLRLTALSALSEQPVTTPAVVAPARKPSQRLLENVVYLLSGAAAINTPERRQAFSSLMRTNHGLYFDIDPALSVARYWQELVERISDSHGSDGLRGLAAATHEFAPDDPATMSIEAALRQLADEAARTPPGQSYRFFLSYSRRDVDQHRVLEFWRALKQQTQTHARRAPKEYDGYIDQNMQLGSHWPSKLYHAATTSRVLIALCSRDYFERSWCGLEWAVFNERARRAGEDTVGILPLRWGDMGKADWPDGVRDVMHTTEALDSVYGGLSLADFGGDHSYRDFVRILSQIIHSLPNSPDLPKLTVEEVNGLTPTFGNDPRPKLHLPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLX7</accession>
    <name>A0A010ZLX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860389.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.693"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458356" evidence="2">
        <location>
            <begin position="28"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="347" mass="36084" checksum="E50D7D3A81F911BC" modified="2014-06-11" version="1">MSRAFDALLAVVLTALSLAVAGQLGHVQPEAQPVDAIGYALTAIACLALVARRWFPAVTLAVTTATVSTYLIAGYPYGPVLIAVAIATYTVVLRYPVRRAVLISGAAMLVLLGHLVFSESLLPGLLPGSAWIVVPFAVGSAVKLNRQAAAAEAQRAADDERLRVAQEVHDVVGHGLAAITMQADIALHLLPTKPSQAEAALTAISATSREALDELRATLEILRDRAPLAGLARLDALTDRITASGTLVRTIVTGEVRPLPRAVDLVAYRIVQESLTNVLRHAGPATATVRVGYGPDSVRIEVADTGPGGPFTEGHGIAGMRERVTSVGGTLAVSGSDGFRVVAELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMT5</accession>
    <name>A0A010ZMT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1030"/>
    <dbReference type="HOGENOM" id="CLU_036814_1_0_11"/>
    <dbReference type="OrthoDB" id="2047341at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="315" mass="32383" checksum="7CE4BB8AC5444D02" modified="2014-06-11" version="1">MSTVTAPAPPVGLPSLSAGPGSGPVPLRPLAVGEILDGGMDLLRRHPGPTLGTAGLTVVVQLLITVPLWWAITGLLSRQSSSLDADILLFLLTLTAASVVAALGSTVAAVITSAAAAVAVIQEAAGAPTSLPVCWARLRPLFGKLLLLGLTLTGLNVVIAAIPIVGYFVPLFGGLMRLSVLALVFEGGTIGSALKRSMQVGSGTAAGLFRQLGIRLLAGAVGGFLWFIMMLPLTIIATTLVQLAVGGDPLVNGDHGALLLLTVAVAFAYYLPLIVVWAFRSGIDTLLYLDGRMRGEALDVEWGLAGRRSRAEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN71</accession>
    <name>A0A010ZN71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1179"/>
    <dbReference type="HOGENOM" id="CLU_082080_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="21455" checksum="E9AA8B872E23123C" modified="2014-06-11" version="1">MSLTRVVLASRNAKKIAELRRILAVAVPQVEVVGLDEVPPYPETVEDGATFAENALLKAREAAEVSGLPAIADDSGIAVDALNGMPGVLSARWAGKPKSDERNLRLVLEQVEDLPDTRLGAAFVCAAALVLPGGEEHVVEGRMEGSLIREPRGTNGFGYDPIFVPSGSVLTSAEMTPADKDAISHRGKAFRSLAEVLATSLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNA3</accession>
    <name>A0A010ZNA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CryarDRAFT_1230</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848955.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1211"/>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_11"/>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="17">
        <location>
            <begin position="318"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="15">
        <location>
            <begin position="405"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="14">
        <location>
            <begin position="538"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="13">
        <location>
            <begin position="610"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EXG80164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="823" mass="87481" checksum="561D19E3DDEFEEED" modified="2014-06-11" version="1">MTRHLVVVGHGMVGQRMVEALTDRDTKAEWRVTVLGEETHPAYDRVALSRYLTDPAAVLGLVSEDWYDGARRTCHLGDPAVSIDRSAHTVRTAAGRELTYDALVLATGSKAFVPPVPGAELAGCHVYRTLDDLDRIRAEATAARAAVVVGGGLLGLEAAGGLRDLGVPVHVVEFAPHLMPQQVDAGGGEALRRLVEQLGVQVHAGVGTASLRSDENGRVTAATLTDGTVLDAQLVVFAAGIRARDELARSVGLDVGTRGGVLVDRSCRTEDPAIWAVGECAAVEGSVYGLVAPGYAMAEVVADRLLGGSGELAEPDMSTKLKLLGVEVASFGATQGPLDVVFSDPVAGIYKKLVISDDARTLLGGVLVGDASVYAGLRPLIGRTLPATPETLLFGEVSVSDDAQVCSCNAVTKKDVVTAITEQGATDVPAIKACTRAGTSCGSCIPMLKSLLDECGVHVSKALCEHFAYSRAELFELVRTSGLRTFSGLIAAHGTGRGCDLCKPAVASILASLGNGYILEGEQAALQDTNDHALANMQRNGTYSVVPRIPGGEITPEKLIVIGEVARDFNLYTKITGGQRIDLFGARLDQLPQIWKRLIDAGFESGQAYGKALRTVKSCVGETWCRYGVQDSVGLAIDLELRYRGLRAPHKIKMAVSGCARECAEARSKDIGVIATENGWNLYVAGNGGFRPRHADLFASDLDTETLLTYVDRILMFYIRTGERLQRTAAWLESLDGGLDYLRSVVCDDVLGIGADLDASMAAHVANYSDEWADTLADPERLARFVPFINAPGVTDSSIEIVYERGQPRPARPGELPLEVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNN9</accession>
    <name>A0A010ZNN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1333"/>
    <dbReference type="HOGENOM" id="CLU_000445_43_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="677" mass="72672" checksum="4A6821731018BED4" modified="2014-06-11" version="1">MESPESAGLPTERSPDLLLGRLELALDASGIGSFDWHLATDELIWDDRLCRLFGVDPDTFGRRIASFYDGLHPADRIRVRALIERAIDEVGEYRAEYRVLRPDGETRWVEARGRVFADADGRPERLIGVATDFTDRHQAWQRQQDAARAEWERAALMTAVTRALAEALTLKDVTQVLTGTLRGAIGASALGVVLMEADRLRVVDAVGYDPLVVADFDGVALTDPRPLAEAVRTRAPLFAGDAEQFAARWPGAAEVGGSAWAYLPMIASGRPVGGFAVRWDKPQPFTSDDRTLLVALGGLAAQSFERARLYDAEHELAAGLQRVMLPRRTDGIRGVSTACRYLPSTDGLQVGGDWYDVIALPSGHIGLVVGDVEGHTAHAAAVMGQLRIGVRAYAAEGHRPEEVMARTNRLLVDLETRLLATCCYVTLDPATGDGVVVRAGHPPPLVVRANGGVELVESAGGLILGVQDAEYRTMAIHIGPGDALVLVTDGLIETPGLTIDAGLRSLAELAAAGAGESAEHLADRIVAPVGPAGHRFDDVAVVVARRDLGDESRIDEARHAIVRGAQGAIGRSRAFVGRTLTRWGFGEIVVEQAVLCASELVTNAIRHGEGLVELALIRYPDRVRLVVEDDSPRPPRVVKAPATSTGGRGLDVVERLSVAWGSEARGTGKIVWAEFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNW8</accession>
    <name>A0A010ZNW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1426"/>
    <dbReference type="HOGENOM" id="CLU_1029404_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="26912" checksum="403EA743DAC988E0" modified="2014-06-11" version="1">MESGLNSDTEQVEVLPEDIVAAPVFVDTTGKRHRRFRTVGFLAGGVAIAYAAMLGLSFAGGPIAPNALLPIPGVPTAAPLAVPDKEPKGDDMSAVSRDEEISRGGDDSNRGRRDGQIDSTSTTTPKLTPSGPAKAPVKATPTKPSATPIKPSPTPTKPSPTPTKPSPTPTKAPPTTKPADPPPTTKPADPPPTTKPADPPPVTTKPADPPPVTTKPADPAPGTGAGGGGGSTAPKPPADPPADPPASNNPPAPVTKAPTASASPSSTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNZ4</accession>
    <name>A0A010ZNZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">obg</name>
        <name evidence="11" type="ORF">CryarDRAFT_1482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849270.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1455"/>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_11"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="348"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="483" mass="51034" checksum="5FEA0A88E173993A" modified="2014-06-11" version="1">MATFVDRVVLHVTAGDGGHGCASVHREKFKPLGGPDGGNGGKGGDVVLVVDPQVHTLLDFHYRPHAKATNGRPGMGANRYGANGTDLELRVPDGTVVQAEDGEILADLTGVGTRYVVAQGGHGGLGNAALATAKRKAPGFALLGEPGESHDVVLELKSVADAGLVGFPSAGKSSLIAVVSAARPKIADYPFTTLVPNLGVVTAGETVFTIADVPGLIPGAATGRGLGLDFLRHIERTAVLVHVVDTATEEPGRDPVADIDALEAELAAYGGLEDRPRLVVLNKVDVPHGREMAEIIRPDLEARGYRVFDVSTVTREGLKPLLFALAAIVEEERERRGAPDPTRIVLRPAAVDETPFTVEPDDEGGFLVRGTKPERWVRQTDFQNDEAVGYLADRLAKLGVEEELAKSGAHAGDAVTIGGVTFDWEPTLGGAAEVLLTRRGEDPRLALTDRAGASDRLLARRRRRGQNPEKGGERGIHDYGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPG0</accession>
    <name>A0A010ZPG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569541.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.132"/>
    <dbReference type="HOGENOM" id="CLU_1265192_0_0_11"/>
    <dbReference type="OrthoDB" id="1953114at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23611" checksum="1C60F17CE1494277" modified="2014-06-11" version="1">MNTGPKGWHQGGADEDSFVPADLSELEWPTRTAVARPLPTTVLWRWRYETAVLGGAPLLWWGSVRSIGGLAGLSVVTGVVAVLASIPALRRWLSGLLWTVVTPHRLRVGCAEAGVVSPQGKLPAVLFTLRKPYGERVYLWCPAGLGPADVAAARPAIAAACWADDVVFYQTSGQYPPLVAVDVVRLPGTVLDTEPKTIPAVWKRFVRHDGRFEGFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQC4</accession>
    <name>A0A010ZQC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease, DNA polymerase III, epsilon subunit family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725692.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1933"/>
    <dbReference type="HOGENOM" id="CLU_022933_0_0_11"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="230"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="660" mass="71381" checksum="4033BAB30B0F3C6C" modified="2014-06-11" version="1">MQQHGSSTTTPKGWVQSTFDELGQPLRDTTFVVVDLETTGGAPGGSAITEIGAVKVRGGEVLGEFQTLVDPGIGIPPFITVLTGITDAMVAAAPPIPEVLPAFLEFARGTVLVAHNAPFDLSHLKAACEAHGMVWPGFRKVDTAVLARRALSRDEVRNCKLSTLAAFFRSPTTPVHRALADAQATVHVLHSLMERLGNLGIQTLEELETFTTQVSEAQRRKRHLAVGVPNAPGVYLFRDARDRPLYVGTSKDLRSRVRQYFVSSEQRSRMAEMINAAERIEAIVCAHSLEAEVRELRLIAAHKPPYNRRSKHPERRLWLRLTTDAYPRLSVVRQARDDGTAYLGPFSSRRSAEAAATAVYDVLPLRQCGGVLSTRKTSPACALAEIRKCEAPCEHRVSVEAYGRHAAAFREAVQGDPSRLVERLLSRIESLADRQRYEEAAVARNRLSALLRAVIRSQRTRAISVVPELVAARADGAGGWEISVVRHGRLAAAGVAARGVPPMPVVDQLVAAAETVERDPASEGLHLEEIERVLAWVERPETRLVKVDTVWSSPARGAGRWAQLVGRMEAGRHGADPFGDRRRLRPESRPAVPVTLAAPGSSNLSTHGAREPESIPHGPGGGTPHGDRGVPAPPAASAPQRGPAGDTELHPRLGGAPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQW0</accession>
    <name>A0A010ZQW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848344.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023846_0_0_11"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="217"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="238"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="658" mass="71293" checksum="2752A8E9D3951859" modified="2014-06-11" version="1">MAQLALHVEFLGEFGRLEPDERAQVRAALSQLTPRTVPGARDPRIEVARLTDRLSAVVTAPDDVQLLLGVRADAEDWAKSHVLSVNTASGVLEITDADAVERLLPDLRKAAEEAPALLFARLSDAQLGRAGISPDTLAVARTIRTLDQLRDLAGVLPEAQYATLHLLGDGLPPAAAAQEFDPDDLAAAIHRSQGRIALVDDVDTLLSIAPSRQRAFLHPEQEAVAYRSGFAGPATMFGGPGTGKTVTALHRVRHLVLRDPASPVLFVTFSDELSVAAERDLAQILDERHRVAVRVASVNQFASELVSERYGALRLLTDEEYARLWADVSRRTGGTYGPAFVRREWESVVFAHDVADLDGYLAADRRGRGRRLSTGQKQQLWPALAEASRVLLATGVWTPLTIADRAAALLQERAEKPFAHVVADEVQDMHPAQWRLLRAAVAPGPDDLFLTGDPHQRIHGYRVRLDRLGVDVGGRSTRLMVNYRTTAEILDWAMRVLSEPDSDDLDGGIDSMRGYRSVRHGQEPELVAYPTATAELDGLVTTVREWHADGVEWSEIGVAARTPAIARSAASALAAADVPGVTVGTMHGMKGLEFRRVALIGVNGGTLPDPAALTPEDDDPVAYALDLQQERSVLFVAATRASDVLRVSWWGAASSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR42</accession>
    <name>A0A010ZR42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAMP domain-containing protein,'ATPase, histidine kinase/DNA gyrase B/HSP90-like',nitrate and nitrite sensing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569697.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.706"/>
    <dbReference type="HOGENOM" id="CLU_008825_0_0_11"/>
    <dbReference type="OrthoDB" id="811938at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458403" evidence="6">
        <location>
            <begin position="39"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="322"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="945"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1118" mass="117910" checksum="E5DCA115B301C4B1" modified="2014-06-11" version="1">MFLDRLKISGKLVLLAIIPLLAVSVLALSVIVGRISDADNANDNSRDIQAAGEVATLVRELQAERLLTIGFLAGGFATKSEVLQQEAIVDDQIATVKESISDESPPTLVKAVGDLKQLVDLRKESLATNVPQTVVSQQLTGLINSLIDGLQLYRISDASTSIGRQILAMDSALHLGEQNSLNLATLTLLLATPNATLLSQYVSGLGTSSEYTNAYFQYANPTQATLYRLVQTANNARTSTELADLGTKADLGRVRELPLATYFPRFQSFLGQTRYIETKLVSDIVAATENQRRDAIAAAAGIGAALVLILGLVGVLTLLVGRRVSQPLVALASSANRIATAVETELTRVADDESEVFEPVRLDTVNTTGRDEIGELARAFEQVQDTAARLVERQITSRRNVATMFGHIGRRTQNLIGRQLSMIDRLERQETNTERLSSLYQLDHLSSRLNRNAGSLVVLSGSMATEQGGGTPLALGDIARLALGEIEDYTRVDIDVPEDIVVQPSVISDLTLIFAELMENATAYSPPHTRVTLSAEATRAGAQILIVDHGIGMASERLAEENARLARRERLDLAPTEVLGLFVTGRLARRHGISVALVPTSGGGVTAVLALIEQHLVPSIYQGIATVEEPPRALPAGPPMGQPEVLRVPNTAMPADPAATPSYAQPTGGFQQPAAVGYDQPQYGQPQYDQPQYGQPQYEQPRYDQPRYDQPNPAYEPAPVYEQPNPGYEPAANLPVVASNAMFDNVALERASRAISAGPWNAFSGNEAPVPGQREPVDVEPVGASAALYRSDAPPAQAPATDVSWWDNAPGARPTEPVQPAQPAAFRSLPAAPAQPAARPAPIAPAPPMPIPQPMAAPIPQPLSTSTTQPLPVRSAPVPAQPAAAGPPAGSTLPRLQRRVPGAQLPVGVNTAGKQAEPQILGDAGDPAAARALIEEFEAGVRNAQRAGDTGPVPQMAPPPSNGSNGSNGSHGYAPGPRPGSMSAQQATFGTPPPGPVHTPPPVAQPTWNSQQAAGHAAPSRHVPAAAPVSPPVLPQRPAPAGPPPQQQAQRTSGGLQRRVPGATLKSFTSGRGGASVTATPVADPDAARALIEQIEAGVSRALNRVVVDDHQHEGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRB7</accession>
    <name>A0A010ZRB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain HDIG-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.775"/>
    <dbReference type="HOGENOM" id="CLU_105441_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="20871" checksum="24CEE1159BF7165C" modified="2014-06-11" version="1">MVVMACEFGIELSRDLARVLLPPPAERWFHTAGVAARARQLASAVDQEDRDLLVAAAWLHDIGYADQVRDTGFHPLDGARYLDRLGLPKRLTSLVAHHSGARFVAEARGLGAAMADFPVEVSLVSDALTYADQTVGPHGRPYSVDKRMAEMLGRHGPDSPQARAHRARAPYLRGVASRMENVLRLVTVGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRI3</accession>
    <name>A0A010ZRI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma subunit, SigV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570041.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="20209" checksum="00C8C998ABCACF96" modified="2014-06-11" version="1">MGRAADDEAFEAFVNQRSRALLRYGFLLAGDPHTAADLVQEALLRLRDAWEHGRGQEHPDAYVRTTMYRLHISWWRRLRREHVSERVPDTAVIDPGLRRVEDDTGLWPALRTLGRRQRAVLVLRYYEGLDDDRIAELLGISRVTVRTQAMRGLRTLREQLTEETVPTGPRRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRN5</accession>
    <name>A0A010ZRN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850545.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2346"/>
    <dbReference type="HOGENOM" id="CLU_027555_0_0_11"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="519" mass="52605" checksum="44598AC3927F0581" modified="2014-06-11" version="1">MELTGEMLIGARAVRGTAGTVHGRDPRTGDALAPSYGLGDAADVAAAASLAAAAFGVYRSTTGEQRGALLDTIAAGLEEIAEPLVARVAAETGIAEPRVRGELARTTGQLRMFGALAREGSWISARIDPALPERTPLPRPDLRQRRVPTGPVAVFGASNFPLAFSVAGGDTASALAVGCPVVVKAHSAHPGTSELVGRVIQGAVAALGLPEGVFSLLFGDGESLGVALVRDPRIRAVGFTGSRSGGTALTAAAAARPVPIPVFAEMSSVNPVFLLPGALATRGAELGAAFVTSLTTGAGQLCTNPGLLFAIEGPGLDEFLGAAAAAIAEVDAAAMLTAGIRAAYDDGVSRLREHPLVTEVAAGPGSPGLSTPHLFTTTADAFLADRGLQDEVFGAAALVVRVTGFAEVIDALEGQLTATVHAAAEDLDLAASLLPSLELLAGRIVFDGWPTGVEVGSATVHGGPYPSTSDGRSTSVGTAAIERFLRPVAYQNLPPALRPPGLDDENTLGLRRTVDGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRX0</accession>
    <name>A0A010ZRX0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="20">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="20">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">lysS</name>
        <name evidence="23" type="ORF">CryarDRAFT_1022</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="20">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the LPG synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="20"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1003"/>
    <dbReference type="HOGENOM" id="CLU_008255_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20 23" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="17" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 20 23" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="22">
        <location>
            <begin position="820"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1042"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EXG79967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1128" mass="122402" checksum="CFEF227C91962454" modified="2014-06-11" version="1">MPNPRFGPDRALAGAIENTHVADDVSADESGRSDPRAGARRGMWEFPQMNERVTSWSGRVVTVAGVWLVVSFPLRHRTWVQWIDAAFELLNVPTARNLFVIVALLLLGSALRRRLRSALIVVIAYQLAAGLLQLPVVAIAAANWSDLDATDLDLDRTEVVLTAVSAAVGVVLGVALLRVRRAFPARLAPGSRRAALAVLAGGLIASWATTVWLTQLFPHTLSGAREHLTWATRSAFGVTAAGDQAGLNGHLGHHWVAVLGGTLSASALLGAVAVFLRAARAAQYLGADDELAVRRLLLESGERDSLGYFATRRDKAVVFSADGRAAVTYRVVASVSLASADPIGHPSSWPAAIEAWLADARGHGWFPAVLSASEAGASAYVDAGLKALSLGDEAIVDVEDFTLDGRTMRPVRQAVTRIRRAGYTLVARRHDAVGPDEWAVLERKAEEWRGDAPERGFSMALGRFGDPSDDRCVLVTAHDANGDVRGLLSFVPWGTRGLSLDLMRRDRDAENGLNEFMVAGLIEACPGLAVSRISLNFAMFRSVFSSADRVGAGPVTRLTDAVLSVASRFWQLESLYRSNAKYLPAWLPRFVCYDSSLTLTRAAVAAGMSEGFLPALTPSGRMLEDGFAEKVTRQEADLLRPARPQYRLNQQQRARRAKAEQLEDPYPVRVPRTTSLSEVRTAHGGLAPGERTGAPVSVTGRVRALRDLGGVSFGVLQEDGVTLQVMLTADGTPESVRRRWKQTVDLGDHVAVTGEVVTSDRGELSVLAEDWTMAAKCLRPLPDAHAGFSDPEARVRQRYLDLLVNDDAMRVLTHRSTAVRALRDGFAARGFTEVETPMLQAVHGGATARPFRTHINAYDTDLYLRIAPELYLKRLCVAGMSKVFELNRNFRNEGADATHNPEFTALEAYQAHADYTDMRELTRELILDVATSVHGSPVAVRPEGPVDLTAPWPVVTVHDAISRATGARLTSDTPLADFRRVCAEHGVNAPADATPGELAAALYDALVEKNTTYPTFYTDFPLDTSPLTRTHRDDPRLAERWDLVAYGAELGTAYSELVDPIDQRERLTTQSIKAAAGDPEAMQIDEAFLTALEYAMPPTGGLGLGVDRLVMFLTGTSIRATLAFPFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS49</accession>
    <name>A0A010ZS49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850828.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_0_11"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="25599" checksum="30A440AEC4105CAA" modified="2014-06-11" version="1">MAPKRRHSYFAGKVTAIPGASQAEVLNELRRVILAGEVPPGVQIPVGDVAERFGISPIPVRESLMTLIGEGLVDHRPRSGYTVAQLTLAELREVYVVRRVLEAAALAAAVVAADHADDVRAAEALAALERAVTDDDSAGYHRESRRFHMALLAPAGMQRLRYVLESAWNVTEPCRPMAYIGVEERTALHADHHAMLDAFTARDAKLLLDISATHHHRLENSIADLPPETGLFATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSB0</accession>
    <name>A0A010ZSB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal-dependent protease of the PAD1/JAB1 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M67.009"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1152"/>
    <dbReference type="HOGENOM" id="CLU_116765_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="15307" checksum="105BA041EC6458A1" modified="2014-06-11" version="1">MGVLKLDRAIQDAIVAHARRDHPDEACGVVAGPAGSDRPVRFIPMLNAARSPTFYEFDSTDLLKLYRDMDDRDEEPVVIYHSHTATEAYPSRTDISYANEPGAHYVLVSTREEDRVEFRSFRIVDGVVTEEPVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSC1</accession>
    <name>A0A010ZSC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850948.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2658"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16061" checksum="5C47A6550ED5012E" modified="2014-06-11" version="1">MTSPLDDDVDRTLVTVLAADGRATLSTLAAAAGLSVSATQSRVRRLEQRGVIRGYAADVDPDALGLPLAAFVSITPLDPAQPDEAPAQLAALDAVEACYSVAGEASYLLLVRVPTPRALEELLREIRIVANVRTHTTVVLQTFYERRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSY3</accession>
    <name>A0A010ZSY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849146.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1362"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_11"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="35487" checksum="446C8EE03654E037" modified="2014-06-11" version="1">MVDLRHHGDAEVREAGLVDLAVNVRQGAMPGWLAGPVRESLEDLAAYPDQTGARAAVAARHGRPPEEVLLTAGAAEAFVLLARVLRPRRAVVVHPQFTEPEAALLAAGHAVTRTVLRAADGFVLDPALVPDDADLVVIGNPTNPTSVLHPAVSLAALARPGRTLVVDEAFADTIAGEPESVAGRRELPGLVVVRSLTKTWQLAGLRVGYVLAPAGLVGALGEAQPLWGVSTPALAAAVACSSARAVAAADEFAAALADEREYLLAGLRAVTGVRVHGVPASSFVLIETPGAAALRERLRRSGWAVRRGDTFPGLGPDWLRVAVRDRVTTDRFLSALAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT32</accession>
    <name>A0A010ZT32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851301.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="27950" checksum="EF9B67B56519D069" modified="2014-06-11" version="1">MSRLAGKVAFVTGAARGQGRAEALALAAEGADVVVTDVCAAPTRTDYPAATPEDLAETVRQVEALDRRVVSGIADVRDAGALEDLVARGVAELGRLDVVVANAGIVTWGRLWEMDLDRWRDMIDINLTGVFHTLRASIPPMIAAGNGGSIIITSSVAGIKSLPGQAHYSAAKHGVVGLAKSAAAELAPYRIRVNTIHPWGVATAMGEMGADGAKVFADNPSYAASMGQLLFDPPISQPSDIAAGVVYLASDDARVVTGTQLTLDHGATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTL5</accession>
    <name>A0A010ZTL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851572.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3131"/>
    <dbReference type="HOGENOM" id="CLU_000445_100_0_11"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="188"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="32343" checksum="4F0FC46BC81EFA69" modified="2014-06-11" version="1">MALDELSVLLARHARPDFTTGIDDLLIVRADRPYAPKAVTYGRILAVTVQGTKRLAIGDRVYDYRAGQYVVASAELPVGSNFTEAGPESPGLGLGLKLDPADVADLLLQISPHDQPDPGVAAGLAVSDASPELLDALLRLVRLLDHPEDVPVLAPLIKREILWRLLTGEQGAMVRQLGLPDSNLSHIARAVRWLRANYTERVLVEDLARIANMSVSAFHRNFHAVTAMSPIQYQKQIRLQEARLQLSARAGDVGAVSRRVGYDSPSQFSREYRRQFGTPPSRDTTHLLTAEPSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTY9</accession>
    <name>A0A010ZTY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075817_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="23109" checksum="24F1A17F64E214C5" modified="2014-06-11" version="1">MRASNTDRERVAAALHEAATEGRIDLHELDARLAQVYSARTYGELIPLTRDIPMPRAEFTPEPTTNTAAHPVLPPSTWAAAVMSGFKRSGPWTVPEKFECIAFWGGGEVDLREAVFTSSTVTIRAVAIMGGIEITVPENATVHVNGIGIMGGFDDNATGPGVPGAPVIIVTGLSFWGGVDVKRKPPKAEIERRRLERKRLKADKRNRRDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU47</accession>
    <name>A0A010ZU47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2865165_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="58" mass="6138" checksum="086D149E2B83245B" modified="2014-06-11" version="1">MIKLYVTLCLRVQELTRDRDRGDGPVPTSIIIAGLAVLAAAVVAWATTKANNAMNSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUD9</accession>
    <name>A0A010ZUD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849886.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183045_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="75" mass="8907" checksum="FF383F9855DF11A7" modified="2014-06-11" version="1">MSTTEERPPEPPARSDRNHWYWLLLIPIIVPLIPMLYNGTDPTLWGIPRFYWLQLLFVVLSVIVTLVVYRQTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVB5</accession>
    <name>A0A010ZVB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852563.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3803"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="9"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="338" mass="35202" checksum="EBFC833E74111DF2" modified="2014-06-11" version="1">MQGVAYEGGGTLRVSTTEVEPPGPGELQIAVAYCGLCGTDLHIAHGNMDARVRTPLIFGHEAAGTVAAVGPGVTGWEVGDPLTVMPLLWDGTCSACLAGHQHICQNLTFVGIDSPGALQQRWNVPASIAVPLPADLDLRAAALVEPVAVAVHDVRRSELQVGDRVVVLGGGPIGVLIGCVARHAGAQVLIAEVDESRRARIAALGFETVDPATDDVVAEVGRWTGGDGADVVFEVSGAAAAARSTTALAKVRGTIVVVAIHAAAREIDLQRVFWRELRLLGARVYQRSDFERAIALLGQGVIPAEELITRVVPLDRTPAAMDDLAAGRAMKILVEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVW9</accession>
    <name>A0A010ZVW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0225 protein CryarDRAFT_4010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0225 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852765.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3984"/>
    <dbReference type="HOGENOM" id="CLU_099590_2_0_11"/>
    <dbReference type="OrthoDB" id="1472440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00612">
        <property type="entry name" value="UPF0225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023006">
        <property type="entry name" value="UPF0225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="13933" checksum="7EAB16567BAAA501" modified="2014-06-11" version="1">MSVCPCGSRRTYDECCGPFHGGGAAPTAEALMRSRYSAFARGLAPYLLSTWHPRTRPGELELDPGITWRALQIVDTVDGGPGDDSGIVEFRAVARTAGGERHVQHERSTFSRVGGRWVYVDGGSGPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWD2</accession>
    <name>A0A010ZWD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850882.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044758_0_0_11"/>
    <dbReference type="OrthoDB" id="1742133at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="27951" checksum="490C725683B4F45C" modified="2014-06-11" version="1">MTTDLDLPDADGRRAALLREFRREPVARPRLLAPAFAAGALAVTVLGAALAGTIVREPPSPATTVAELRARLDHLDATVPPTARSYSPDQFVYVRTPSAETWLSEGGTQRGAVLDADGLRTTEPLVPAPDARKPATVERVIAHPSLTGLLALQDGPVRTAPAELVRHRTPGDAFAAVRALLRVGGLVPERTRTWLYRAAASVPGVTVRTGVADTAGRSGWALTLGRQVILFDPDDGSLLAEASSGPPGPPVLSGTLVRWAGVRPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWE6</accession>
    <name>A0A010ZWE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase 24 kD subunit</fullName>
            <ecNumber evidence="5">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2622"/>
    <dbReference type="HOGENOM" id="CLU_054362_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="165" mass="18047" checksum="A610EF3DE2DDF00F" modified="2014-06-11" version="1">MTRTDESRAALEPPALRRRRRTEPANPLAGLDPQLVLTVRRVVEAHRDWRGPLLPVLHALQDELGYLPADATPILAHELNLSRAEVHGVITFYTDFRSEPGPTRTVRICRAEACQAVGAESLVEAAGGRAEQVFCLGNCALGPSVEVDGRVLGRVTPEKLREVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX51</accession>
    <name>A0A010ZX51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851236.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_4_0_11"/>
    <dbReference type="OrthoDB" id="1808868at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="37138" checksum="77438B95B06501A8" modified="2014-06-11" version="1">MKQRIWAWVRTLGGVAIIGILLWRLGSNAFLDGLRVINVWSLLAAFGIGLLATVASAWRWVLAARGLGIRMPLHSAVADYYQSLFLNATLPGGLLGDVHRAVRNGRDTGDVGRGVRAVVLERFAGQVAMFVIGGAVLLAHPWLLHYVWVRVPRSLLVGVLVAVVVLTAVVASRPGLRRRAAAVGRDVRCGLLAKRNWIWVGISSAVVVVSHLATFVLAARAAGATAPIGQLLPLMVLALLVMAVPLSVGGWGPREGFCAWAFGLAGLGAQAGLTIAVVYGLFALVAALPGIAVLGYRLVVRRRAAVAPVSPAVAPAAPRAMLAIEAAPTGPAPLPLEPAARTAASDSRRELATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXM3</accession>
    <name>A0A010ZXM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3058"/>
    <dbReference type="HOGENOM" id="CLU_022601_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PTHR18896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="536" mass="59124" checksum="AF60196D90320617" modified="2014-06-11" version="1">MVAAESNGSNRGSRVPPSNVCGVSSDVDDSPVSAQALAARFFPPSTEACPTLVEDSHWQPIVDGVAYFQELTRLLEQVGPGDAVYIASYQADPDLDLGRPLKDLLAEKVADGADVRVVLSAAEYSGGIPWLPFGPFRANVVAARALRGWLPTTREVATPPLHDRVLLDWSGPVLGSNHQKLIVFSINRTLTAFVGGLDLVPSRWDTTPHDRLRLGVHRWGWHDGAARLCGPAAQRVWEVFRSRWENAVKLPPRFLPRRWFVYPRGGATALNPADAPRTVPPPPAQPARDAPGVALRVLRSYAPWKVYRRGMRTPAVVRKGTYEVYGTLITAIRAARRYIYLEDQYFHESPGGNRHYELYGELRAAAERGVKVILVGSGRRDPADGGDSTVRPVITGDLRRMIKRLPPPARTNVVMYRVRDLTVHTKLMLIDDVFASIGSANFFSRSMVGTDSELTCAVVTTGRAVTELRVSLWAEHLRAPAVDDLEDLDTALGIWRTEWLPAGHPPDTWRRAGAPAGFAPAEQVLIPARYSRWSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0J1</accession>
    <name>A0A011A0J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_4219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Set transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570723.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055598_3_0_11"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004750">
        <property type="entry name" value="Sugar_efflux"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23535:SF2">
        <property type="entry name" value="PTHR23535:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="15"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG83012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="402" mass="41349" checksum="53221479608D2401" modified="2014-06-11" version="1">MTAVAEAPAREGARLWVPLSLVFLSVGLSMAMMFPFRALFLTDAVHAGPLLVTVFLIVAPVSGVVAASWIGRWSDTGPYRSRLIVAAALAGVVGSGLSAFVRNYWVLLFVTATAIAVSTAALPQLFAYARVVVGGGDRGTFSVSVLRTLMSASWVAGPLVAAILIEVGGYTLIFSVAAAIFAAVALLTHFGLPEPRGGAPAASEHPETPAEAPPIPAAGPVDVSEGSLRLNVVALVLIQTAATLSVQLLPLFVNADLNGDVRDTGFILGLCAFLEIPLILAFGALAARAGVRRLFLIGPLVSALYLGTVALSAGTGQVALAQLLNASGIALIQGIGITYFQDLLPSRPGRASTLFSNAFPIGSTLAAPLLGIAQQVGYRFGFVAAAVLSLAGLALLVTRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAI5</accession>
    <name>A0A011AAI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136228_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021919">
        <property type="entry name" value="CCB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12046">
        <property type="entry name" value="CCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13721" checksum="EC0813345D782751" modified="2014-06-11" version="1">MAEEPKIPQRVRVVLGDMPQARRTPPVRAELDQQTDVGEVLVRGLVRAQLGLAVRMAALVALTVGSLPLVFALFPGLAETTLFGVRLPWLLLGVAAYPLFVGAGWIYTRGAERNERDFVELVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABX7</accession>
    <name>A0A011ABX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725855.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.564"/>
    <dbReference type="HOGENOM" id="CLU_068888_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29253" checksum="BFD235B25F471F8C" modified="2014-06-11" version="1">MLEIHTEIRETGPDRYATLIDGGWAIGSSLNGGYLQLPVVRAVLAAEGHPHPVAVTTDYLQAPHAGEAEIVVERLRTGKTIGTSRATLIQDGQPCLVSSVVTSTLDSNAPDVDLAPPIELPSPDQCTRIRSDVMPGTNLALMDHVDVRLAPEFANVVRGRPDGSMALRGWVRMVDGRDPDPLVCLLAADAFPPVTFTIGRYGWAPTVQLTTYLRVLPAPGWLRCELRGRVLANGWFDEDCTIRDSAGRLVAQSRQIARIPRVPTPSPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACP6</accession>
    <name>A0A011ACP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.841"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="391" mass="41592" checksum="84F3374E472D3D73" modified="2014-06-11" version="1">MTTTECADPRSPWGRGHSPGLRVELPIAVGLTVIIGATLLGLPEAAHRLLVLDLVVAAVSVAMVPVMLRWPVPAAIALAVLTLVSPAATPSASAASMLVAQSRPFRLAALVGVGSVAAQAVQAAWRPTASLGYGWWLVLITVAWAALIGWGTVMRVRRELLISLQERARRAEADRDRRVAEARLAERTRIAREMHDVLAHRLTLLATYAGALEYRPDSAPEKLSAAAGVIRSGVREALEELRGVITVLREDESDDELRPQPSLADLDRLVGESRDAGTTVAFENDLAEVDADVPAATGRTVYRIVQEGLTNARKHAPGAPVTIVLTGAPGDGLRIELRNPVPVATTAEPLPGAGLGLLGLTERVQLARGELDHGIGPDGEFHLRVRIPWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE47</accession>
    <name>A0A011AE47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">CryarDRAFT_1370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1346"/>
    <dbReference type="HOGENOM" id="CLU_054212_1_2_11"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="34304" checksum="AD4878AF78D58D1A" modified="2014-06-11" version="1">MSAPSRSDLLATATGLALGALLDHVVPDPRRGHPVAVFGRFAGALERRLYAPTRARGALFAALAVGAPVVAGVAVDRLTRRRPVLRAAATAVTTWAVVGGTSLRREAAAMDRLLAADDLPGARARLSHLCGRDPSGLEPPAVARAVVESVAENTADAVVAPYFWGAVAGLPGLVGYRAANTLDAMVGHRSPRYAEFGWASARFDDLLNLAPSRLTALLTIGAAPAVRRDSAADAWRTWRRDGNAHPSPNAGQCEAATAGALGIRLGGRNTYGGTVDERPVLGDGRAAEPADITPAARLSFLVGATAAALGAIALSLRAAMTSRSGPRRARATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE67</accession>
    <name>A0A011AE67_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849152.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1366"/>
    <dbReference type="HOGENOM" id="CLU_037265_2_1_11"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="25614" checksum="11A18950E6A79789" modified="2014-06-11" version="1">MTLRDAIARLSAVETLLVATDYDGVLAPIVSDPAKAFPLPAGIDALQELVTLPRTSVALLSGRALVDLARLSGLGGEALLVGTHGVEFDDGFAIPSEAADLRARLLAELGSLVGTVPGAALEEKIASVAVHVRNADADAGEKLLAGVAAGPGSWPGVHSTAGKKVLELAVVETSKGTALDVLRERTGADAVLFAGDDVTDEKAFAVLRPGDVGVKVGPGETAAEYRVDDPEAIVAMFALLSEERRLHVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEE2</accession>
    <name>A0A011AEE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease, Rne/Rng family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569879.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1452"/>
    <dbReference type="HOGENOM" id="CLU_003468_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="573"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="948"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="951"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1133" mass="118851" checksum="ADB209720084CB91" modified="2014-06-11" version="1">MLDNELTGAGSAGEIPTGQTTGSTTSDSSAASTGAGAPTTPEPAARPARRRAARRPAGPPADPPSNGPDLPADAVPAAVIAPSPAPADDTNAADLADPAWPVVPAPVADEPAAAEPAPRRRATRSRRRAAEPEAVPDAPSTSETPGVPAASAEAPAGPALAEPATAEPATTEAPADPTPPDVAVEVTPPRARRRRRAAGAEPEATEPPVAASTVTSGVADQPPAATEAAVVEETPAPTSRRRRRSAGAPAATTGADAPEPIAAGDGASVTSAPKTDVPDAGAAEAATGEPGLRTADTPFAGTEAAEQPSTHRTRVRRAPMVTFMAPDPAAVPFRAPEPEPEPVEDEIEPADELEDTEDTTNDETTADADADADADSDEDGSDESRRRRRRGRRGRGRGRGENGGEAGDADSDEQSADDESDPTASDETDEADDESADGAADGDEDGGTSRRRRRRRRRGAGDAEVSSDDPPNTVVKVRQPAPAAPPRSIEDEVQGVKGSTRLEAKRQRRREGRESNRRRPPVLSEAEFLARREAVERVMVVRQVGDRTQIAVLEDDVLVEHYVTKASSAAYAGNVYLGRVQNVLPSMEAAFVDIGKGRNAVLYAGEVNWDAAGLEGRPRKIEAALRSGDSVLVQVTKDPIGHKGARLTSQVSLPGRFLVYVPEGQMTGISRKLPDTERKRLKDILKKIVPENAGVIIRTAAEGASEAELTHDVERLEAQWQAIKEKSTKGSAPSLLNAEPDLVIRVIRDVFNEDFSKLVVSGTEAWPEVEEYVRDMSPDLAERLVHHTAETDVFAAYRIDEQLMKALDRKVWLPSGGSLVIDRTEAMTVVDVNTGKFTGQGGNLEETVTRNNLEAAEEIVRQLRLRDIGGIIVIDFIDMVLEGNRELVLRRLTECLGRDRTKHQVAEVTSLGLVQMTRKRVGQGLLEAFSETCETCRGRGVIIHSEPLIGRQTGGNGSNGGNGGNGHQHAEPAVAEVKEGRRSRRKRGGGGGGEPVGPTAAPAVAAAAAAIHAASARAVAVPADDDDDDALVVDEIVEAEGDLAYDVPDAEIEPVVTSGAATAHIAAAATVEDTDPLKPADQMVVNGVATVPAIAEPAPDEVLVGEPAPVKRPRRARRAASRPAGPPEGAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEE7</accession>
    <name>A0A011AEE7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">CryarDRAFT_1484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849275.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1457"/>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_11"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="420" mass="43482" checksum="16DCFB0794A5A027" modified="2014-06-11" version="1">MTTEQEVRAVAARSKEAAAELAPLSRAEKDAALLAMADALVAASASVLAANERDLSAGREAGLAEGLLDRLALSEERIAGMAQGLRDVAGLPDPIGEVVRGYTLPNGLEVRQIRVPLGVVGIIYEARPNVTVDAAGLCLKSGNAALLRGSASAHHSNTALVGVLSEAAAKAGLPADAVQLVPGVDRESVTHLMRARGLVDVIIPRGGAGLIKNVVENSIVPVIETGVGNCHVYVDAAADLEMAASITMNSKVQRPSVCNAAETLLVHSSVAATFLPVVGAQLHEAGVTLHVDSRAAASVPSGPLTVPATDADWETEYNSLDLAVRVVDSVDEAVAHIRRWGSGHTEAIVSSDTRAIRRFSSRLDSAAVMVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPEMTSTSYLVTGDGHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEM4</accession>
    <name>A0A011AEM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849397.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1533"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="63"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="36772" checksum="D327F26F6C7A8CBE" modified="2014-06-11" version="1">MSDVISGPRSGLGRRGFLFGGAAVGATLLAAGCTSNDSGDDRPETNTKAVGGDNAAKGTQVTIGFSAPQADHGWIGAIAKNAEAQAKTFEDVTFEPVEPTNDVAAQIAAIETLITKKVGVLVVLPNDGKQLTAVAAKAMAAGIPVVNLDRVFDSPLAYRTWIGGDNYGMGVSAGNYIAAQLKGKSNPVIAEIAGIDSLPLTQDRSRGFKDALARAGFKVTNRVAAEFTVASGQQVTSNLLQAAPKIDAVWNHDDDQGLGVLAAIRQANRSEFLMVGGAGSLDAMELIKADNSVLKATVTYSPSMASSAISIARLIGQKKGFSDLVENDVPASITLSSATVTKENVDQYLKTGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFF4</accession>
    <name>A0A011AFF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase I family protein with 3'-5'-exonuclease and polymerase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725685.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1798"/>
    <dbReference type="HOGENOM" id="CLU_035229_0_0_11"/>
    <dbReference type="OrthoDB" id="461084at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="316"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="602" mass="63160" checksum="7CD929D362AAA492" modified="2014-06-11" version="1">MGLVPAWGGGGWLAEIDAAGQVTGPVRWCADGAALARAVAEREAAEKPRWLWPTATAVYPALLAAGVRVERCHDVELVESLLVGYEGHWGEPRSLAAALARARGLPVPPDRPPRPRDTQPVLFAADVEATVETTESLDVLAEVYRAQLRRIAAVEHPDRFRLLVAAESAGALAAAEMGHDGLPWSAERHDALLESMLGARPLPGDLPARLHELAADVRAAFGGMKVNPDAPADVVRAFGRVGIQIPSTRSWVLKRVEHPAVAPILAYKELSRIFAAHGWSWQDTWVSGGRMRPEYVAGGVVSGRWATRGGAALQLPKAVRQAVVADPGHVFVAADASALEPRVLAAMSGDRRLAEFAAAGDLYTALAADAFDNDRARAKLGMLGALYGQTSGEGGRLAHVLRRRFPDALAAVDSAARAGEEGRLVRSRLGRTCPPPGRSWLSDPGGEGSPTGEAPALDAIGGRSGGGGTDGAGGGAGGHGDGASGDGGFGDAGEGEPGAADQARRAARGRFTRNFLVQATAAEWALIWLVGLRRRLGPTEAAGARLVFFVHDEVVVHCPEPMADEVRTAVLAAADEARRLLFGETPVRFPLDVAVVRSYADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFJ1</accession>
    <name>A0A011AFJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase-like glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1828"/>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="82"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="580" mass="59197" checksum="C4418EE650F89D85" modified="2014-06-11" version="1">MARHARIAPSRFDRPGGGSRRPLFLAIAGVVVIGLVVGGVWVTRERPSSPSPDGTSAPAPSGDTAAQARAIASKLEDVDLVGQMLMPFVYGDDPDEVSASTRELNQARTGAGTPAEIITKYRLGGVILVRRASDDPTAPTNPASNIGSPAQVRKLTDGLQKTAAELPAGVPLMIGVDQEHGTVTRIRDGVTRLPTAMAFGAADDPALTEQAAAVSGSELAALGIDVDFAPDADVIGGPGNTVIGSRSFGADPGLVSRHVVASVRGYQKAGVATALKHFPGHGHTDVDSHEAIPVLGQDRSALDQDDLAPFKAGIDAGSRIVMSGHLDVEAIDPGTPASLSHKVLTDLLRGELGFTGMVVTDGLDMKALTDRYPAGEVAVRAVLAGNDLLLLPPDVKGAQQALLGALKSGRLPRERAVEAVTRVLTVKLASRPAAPGLDSLKSAQHVSAVERASAAAITVLRGKCSGPLVRGPVTITGGSSEARAFLTAALDRVGVKIGAGGDSIHLAGYLDTAADLRPASVTVATDTPYVLASAKSPTLLATYGTVESSMKALANVLVGRAKAPGKAPVPVSGLPRSACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFJ5</accession>
    <name>A0A011AFJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1833"/>
    <dbReference type="HOGENOM" id="CLU_037725_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="162"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="41036" checksum="2418348CFB5DC094" modified="2014-06-11" version="1">MTSAPLAATLRRIERASGALATRSVARMDDTLPWFRALPADQRSWVTLVVQAGIGSLVQWMRSPISRPKVTGDVFGAAPREMARSVTLQQALAMVKITVEVAEEQAGELAAPGEESELREAILRYSREVAFATAEVYARAAETRGAWDLRLQALLVDALLRGDPADALASRAAALGWTDLSPVSVVIGTAPGSATVADSDQIVDSLVHIGRRAGLDVLAGVQGQRLVAVLGGADDPVRATQMLLAEFGPGPVVVGHAVPTLSGAPESARAAEAGWRAVAAWPAAPRPVAAADLLPERVLAGDTEARRRLVSDVYKPLDAAGPTLVETLSVYLDSGGTLEGTARMLFVHPNTVRYRLRRISEITGLAPTNPREAFSLRLALAIGRMHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFM3</accession>
    <name>A0A011AFM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000096_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="29646" checksum="923BB7E19A427327" modified="2014-06-11" version="1">MTALSADQPRSGSFTAEWRCTGGKAHAWRRLVVPELEVVHSSAALVRQPGKIFLGTLHSRSLKPPVVIVAPADAVASYVRSSAAAARALYTAVGTQEGGVRLLLVHITEEVRNLGRRPARTRPVGPRPRRGVPLDGRPLRPFLTGQGGGRVGLYTGVCLGRRPDQPFRHLLIRQGAARASAPGSLSRASPRCGQRMTNMNEWVHVFLICDAGKANQAAMAAEPAVTRRSVACAALGGLSQPLAGEAVKLTSVGMSTHHTGRRPLGRRGLHDGRAMRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFQ2</accession>
    <name>A0A011AFQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725690.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084465_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27811" checksum="D17659E07CF1DD38" modified="2014-06-11" version="1">MPAFAALVRAGFRRHSTYRRATLASAFTNSVFGFLKTYVLLAVAANGAVAGYDAAALAMFAWAGQGLIGVVQVFQWNELADRIRTGDIVADLLRPVDPLVSFLAVDLGRALHALAVRLTVPLAVGALFFPLRWPEHRTTWLWVVLSVVLATVTSFATRYLINLLAFWWLDARGPGTLWLVGGTLFTGLAVPIPFFPGWAQTVLWCTPFPWMLQAPLDVLLERGSAVTLVAGGALAAGLTLAAAASAQRVAVRRLVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGI5</accession>
    <name>A0A011AGI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850311.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2194"/>
    <dbReference type="HOGENOM" id="CLU_069356_10_0_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="19294" checksum="948FE32515B5CEE7" modified="2014-06-11" version="1">MAARSSDPEATRAAILGVARLQFGERGFDRTTIRSVATAAGVDPALVMHYFRNKAGLFAEASRVDVRIPDLSGVPPERLASVLVPFFVADWGPDGRLLPLLRAAASNRAAADTLVEMFTEYVAPALGALAVDRPEERAAMIGSQVVGVAVARHIIGLPALVDMDDATLADWLGPTIARYLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH74</accession>
    <name>A0A011AH74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186189_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459487" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="51" mass="5275" checksum="5C3CDCA5F919C185" modified="2014-06-11" version="1">MLKKVLKWGAIALLVFFVVTQPADAAGVVRSLGDGLVNIASGMSAFVTNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIM0</accession>
    <name>A0A011AIM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2942"/>
    <dbReference type="HOGENOM" id="CLU_1683641_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459590" evidence="1">
        <location>
            <begin position="49"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="156" mass="16220" checksum="8465C9CFB05F9EC2" modified="2014-06-11" version="1">MMSMLSSGPSATRRRLAPLWVGLAVLVVLVVAGAAVFFATSGDAGASAADNGKRRSAAELARKGLNCMQTTPVTQGVAPAQERVKCQTGGGGDAVISTFDSASAARKDAEQAFAKLSSTAKKDRGLVFGSYWTVSCSFRQVCEGARDYLDGEMMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJN3</accession>
    <name>A0A011AJN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570369.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2600214_0_0_11"/>
    <dbReference type="OrthoDB" id="1897239at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015068">
        <property type="entry name" value="DUF1877"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035944">
        <property type="entry name" value="YfbM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="82" mass="8753" checksum="297AD195C7CB6DE2" modified="2014-06-11" version="1">MSMQLIGRRLSSAEARVLLDDPTTVETLLYGDPDDDEMVQPELDLGKNWHALHYILNGSAWGIGEGAGAAILGGVEVGEDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJX4</accession>
    <name>A0A011AJX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851952.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376178_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045592">
        <property type="entry name" value="DUF6461"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20062">
        <property type="entry name" value="DUF6461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="20856" checksum="F41312234DACE5A5" modified="2014-06-11" version="1">MLDEYSPDWIGRAGLDLGPGYCITIALAISSTEALRRAGVPGVLPRVYDALRREARLLGGDYVPVAAFDVGGHAVLVEENGGMGLYRWGGPLSMGTVAVTAYLSPSSGAERLVITRDGAAVAEVDADEPEVVRTDDPALREVLLALVADAFQPFEDEDDPDADGMPDLLRVACEYVGIHPSVHDVAVPAPGAPVRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK30</accession>
    <name>A0A011AK30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570442.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3455"/>
    <dbReference type="HOGENOM" id="CLU_004665_6_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="4">
        <location>
            <begin position="96"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="608" mass="66318" checksum="9520C5A428728DC4" modified="2014-06-11" version="1">MVRFTLLGPVRAVTDAGDLTLGSPQQRGLLSLLLLRNTPVPIEDVVDALWGAEPPPSAHSTVRTYAARLRQVLPAAEAELRRSASGYSLVRHRAEVDADEFDLLVRRARVARRSGDMTETAAALRRALDLWAGPALGGVHAEFAAAQRTRLEESYRTAREQWFDAELALGRHEAICADLGAAVAERPMDARLTELWMTALHRSGRTVEALEAFRRLRTRLHQELGIEPGPELQRLHQRLLRGDEVVVPPTGPDEPRSVRPDQTPPDIQDFTGRRAEVDRLRHILTRDGAALAGITGLGGSGKSTLAVHVAHLFAEHFPDGRVHLDLGARTGRPMGVHEALGSLLRTVRPGVSVPDTVAERSALWRTIASGRRMLVVLDDADSSAQVEPLLPACAVIVTATRRLLRLSAVSWLRLGPLSDDESLNLLGEIAGHHRIAVEPDPASELVAACSGHPLSVRVAAARLLDRPMWTVERIVAQLDEDFREPVVMHEDCKIVDEPMRRAEGRLDAVVATVFRLGALLVTPVRGVDDVTAMTGLPRAEAHAALEDLVDADLLQAVGAETYRYSPLVQAFARRRAQQVEGPDRCRAALAGLVGAHRDHRSEASRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK83</accession>
    <name>A0A011AK83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2971817_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458560" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="58" mass="6389" checksum="92ADBD17865C5F16" modified="2014-06-11" version="1">MTRLADRLLSLFVPTTSAAAASSFCEYSCQSSYIGRMCYWVWQSSGGYVKQCRGCGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKD1</accession>
    <name>A0A011AKD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852223.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3570"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21729" checksum="7CE7326FA532B060" modified="2014-06-11" version="1">MLKILLAEDVTMVRGALTALLGLEADMTVVGEVGRGDEIVPTALRTRPDVAIIDIDLPVLDGLSAAREMHARLPSCRTLILTGLDRPGTLRRALSLSVSGFLLKDSPYERLVQAVREVASGRRVVDPQLALTAWDIGENPLSAREIQVLRLAAGGAEPQEIAATIHVSLGTVRNYLTKVVMKLNARNRIDAIRIAKDAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKT2</accession>
    <name>A0A011AKT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852449.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3735"/>
    <dbReference type="HOGENOM" id="CLU_030756_4_0_11"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26298" checksum="D7FD37096A424F4B" modified="2014-06-11" version="1">MPTLSSGGAPRRPLVGLTGRRTTASRIGAPPGFADAQAEAYYSEYARGVARAGGLPFHIAVDGPPEAVADAVDALLLTGGEDVDPVRYGSAAGPRSTVLDPTRDAFEVALFEAVLDAGKPILGICRGNQLINVALGGTLVPDLPVGEGASHASYAYPRAHRRHDVRFEAGSIAHRLYGDQALVNSFHHQAVDRPGTGLTVTGRAGDGVVESVEMANAPVLGVQWHPECFDRDPVFDWLVTAAGAPARQHTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALA0</accession>
    <name>A0A011ALA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protease of the Abi (CAAX) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852649.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029799_0_0_11"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="23431" checksum="FBD8D96132C748BB" modified="2014-06-11" version="1">MQPSVVTRARPGWPEVLVGALAYLVAIVVTVVLLRAIPDDQDVFSGLAALALSGVIGLAAFAAAFVIRIRTLAPFGFRRTTGKWLLAGAGGGLLCFLLGLVVSGLYVAFTGDSENIQADYQSAADGGALALVATLLFGAVLTPLGEESYFRGVLANGLERYGPWVSVLVSAAVFAVAHGINPVMPVAFTVGVVTALLFRRTGSLWPGVFVHAVNNALAATVPLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALJ7</accession>
    <name>A0A011ALJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3953"/>
    <dbReference type="HOGENOM" id="CLU_069356_21_2_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="20844" checksum="02A41BD252F8B555" modified="2014-06-11" version="1">MSEVRRRNRRDPEGHRAAILAAAREAFGERGYAGTTLREIARRAGVTHGLITQQFTSKEQLFLAAVPGNSDLAAVAAGDPATLPERIASAFVRRMEAGASGDPLIILLRSTASDERTATTLLAAMQQHSIDVYRDVLGPDLADDLDTRVTLVGAQLIGVAFIRYIARAEPLASMPPEELTGHVARILRHILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFL1</accession>
    <name>A0A010YFL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847365.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.33"/>
    <dbReference type="HOGENOM" id="CLU_131367_0_0_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="18383" checksum="15716EE3626F639D" modified="2014-06-11" version="1">MPEVVLAVARFGFLALLWVFVFAVVGVIRRDLTGARQPRLVATPRGVPLAPAGRPAAEQSKPGRAKRGLFGGGGGSGGGGGAGVPRTLVVTEGALTGTRITLGDSPITLGRADDSTLVLNDDYASAQHARLVPRAGEWLIEDLGSTNGTYLGPTKISAPTPVPLGAPIRIGRTSIELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFV5</accession>
    <name>A0A010YFV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847556.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.124"/>
    <dbReference type="HOGENOM" id="CLU_111585_2_1_11"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="14461" checksum="64A01BE807A1DE79" modified="2014-06-11" version="1">MGTRDEIRALPPEADLARADSLAREIFSDIANKWALLIIEFLGHRTMRFNELRDAIGGISHKVLTQNLRMLERNGLLERTVHPTVPPRVDYDLTEAGHALRAVVDGMCGWTQQYLSHIERSRKRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG30</accession>
    <name>A0A010YG30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847677.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.200"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="30563" checksum="ACB898F1DC07EFE7" modified="2014-06-11" version="1">MRIEISGLTKTYRGGVAALDGLDLTVPTGMFGLLGANGAGKTTLMRILAGVVRPSSGRVTVGGHDLATGAGRTAVQRGLGYLPQDLGVYPDLTARQFLDYVALLKGMDDRAVRRRRVGELLEVVALTPHADRRLRGFSGGMRQRVGIAQALLADPRLLIVDEPTAGLDPEERIRFRTLLSQFAGRRTVLLSTHIVDDIAQTCREVAVLAKGRLIFRGTTDELVRRADGRVWSVVTDGPPPTAGTVVSALPHENGMRYRVVAAGAPDPGAQPVDPGLEDGYLAVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGG3</accession>
    <name>A0A010YGG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569598.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048543_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="27598" checksum="A30AC51578E15F0E" modified="2014-06-11" version="1">MPTDPIHGHHNPGLVRPHPPLPGTPLLDLLAEPTEERQAPPEPSGRDPIALALAGVAALFATVALGVAVLTWLSMSDLQTIVAMSEADQSDTGQQPAPSGQAVAPLPGQPLPDDQFAGPTLGVTGYSQAYRGQALQLTLPPCGSTMTRYVDLDEPRVDADASRADLFYKPRMGCYGTPQLHFVSGVTAAVVTRPTIRPAQCATSIKNAPADNPIAIDGTKVVCVLTSSDKAIGEDITQKMVVLVITAPSANGQSTVRASAWNATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGJ6</accession>
    <name>A0A010YGJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847966.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.389"/>
    <dbReference type="HOGENOM" id="CLU_112632_1_1_11"/>
    <dbReference type="OrthoDB" id="1858654at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="13172" checksum="A6B3C3438010B785" modified="2014-06-11" version="1">MTNDRIVLTGLTVTGYHGVFDFERREGQPFVVDVALELDTRKAAETDEVTDTVHYGELAQKLAAVVQGEPVNLLEKLVARLADVCLDDSRVSAAEVTVHKPKAPIPLEFGDVAVTIRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIM6</accession>
    <name>A0A010YIM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848893.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1155"/>
    <dbReference type="HOGENOM" id="CLU_081757_1_0_11"/>
    <dbReference type="OrthoDB" id="1231841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="26083" checksum="F9C6C7A6B008FE2F" modified="2014-06-11" version="1">MDVEAVTLTTPRVIRRAIMTQWWRDLAFLHWPVDPEVVAPLLPPGTRPDTLGGVTYVGLIGFTMDRVGLGVGVPYFGHFAETNVRLYSVDAAGRRGVVFRSLDAARLLPVVVGRALFGLNYVWSAMSVRRRPDGAYTYRSVRRWPGAGPDAAFTVLPGDPAPPDPLNDFLTARWGLHTVLRGRTIYLPNEHPAWPLRSATLVDLDETLLRSAGLPTLEGPPPSVLFSPGVPVRFGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKQ3</accession>
    <name>A0A010YKQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1843"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="279"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="369" mass="39024" checksum="A8F8FF676F960ED0" modified="2014-06-11" version="1">MLPGGPGYRERMRRLRVLPVIVVVLLCALFVAAYGNRGGPGVVVPLFVVLAWPVLWSARPVLGLGLVLLLTALLTPLYDPETVGPVGCAAVLVAVGRLATVRPWRVSLPGAGVAFAVLALLGAAFYVESGGAFTTALVLALAVGCVWAVGNTIRQGRENAGARRREETELAVAAERLRIARELHDLVAHSMGVIAFQAGAGRRVIETQPREARNALDAIETTSREALAELRRTLAALRRSEPAGAPTIPTPRLADLDRLAASVRVEVTRTGAVRELPANLELSAYRIVQESVTNVVRHAGTDACWVRLDYRGSELGVEVLDSGSGTGPPGTGYGIVGMRERVTLLNGTFAAGPRPEGGFRVAATIPLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKU1</accession>
    <name>A0A010YKU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849943.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1898"/>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_11"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="609" mass="62512" checksum="D932B37D0B903824" modified="2014-06-11" version="1">MPTSVSMPALGESVTEGTVTRWLKQVGDSVAVDEPLLEVSTDKVDTEIPSPVAGTLLSITADEDATVEVGGELGVIGDAGEDAGSGEPAPAEEPAAEEPAAQEPEEAPVAEAPSTEAAEDAPAPQAEAAPSGGDGTSVKMPALGESVTEGTVTRWLKQVGDSVAVDEPLLEVSTDKVDTEIPSPVAGTLLSITADEDATVEVGGELGVIGSADSAPAKSEPSQPKPKAEEPKPKAEEPKSEPKPEPQAAQPPNPPAEESEEPARAAVESTPPQDAAPASAPAPATEASSSDNGQGAYVTPLVRKLAAEHSIDLSSVKGTGVGGRIRKQDVLDAAEAKKAAAAAPAPAAAPAAAPAAAAAPKAPAQPSPLRGRTEKLTRLRKVIAQRMVESLQVAAQLTQVIEVDVTKIAQLRQRAKTDFQARHGVKLTFLPFFAVAAVEALQQYPQLNSVLNMEEGTVTYPAAEHLGIAVDTERGLLVATVRDAGDLNLAGMARKIADLADRTRNNKVTPDELAGATFTLTNTGSVGALFDTPIIFQPNSGILGTGAVVKRAVVINDPNLGEVIAPRSMIYLALSYDHRIVDGADAARFLGAIKQRLEAGAFEGELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL91</accession>
    <name>A0A010YL91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">CryarDRAFT_2100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850153.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2064"/>
    <dbReference type="HOGENOM" id="CLU_038045_3_0_11"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="41417" checksum="633BE846B0061046" modified="2014-06-11" version="1">MKFLHTSDWHVGKVLKGRNRLDEQRAVLREIVGLARTHEVDAVLVAGDLYDSAAPSAEAQELVVRALMALRDTGAEVIAIAGNHDHPRTFDAYRPLMNIAGITMVGSVRTAESGGVVSFTAPHTGEPVKLAVLPFLSQRHAVKAAELVAKTPAENSAGYDQLIRDLLNTLTAGFGDDAVNLVTAHLTVTGGALGGGERAAQSIFEYHVPAGAFPADAHYVALGHLHRRQTLPAACPVVYSGAPIAVDFGEQDNTPTVCLVEATPSTPARTTDLPLTSAKRLRTLHGTIAELGERAAEHAEDYLRVVVREPARAGLREEVQAILPGALEVRIDPEFAAPLQTTRPDRRDDQSGPAELFAEFLTERKIVDERVQSLFTRLHDEVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMG2</accession>
    <name>A0A010YMG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2490"/>
    <dbReference type="HOGENOM" id="CLU_118065_0_0_11"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16769" checksum="71FAA8A2BF889EF7" modified="2014-06-11" version="1">MVAKRSAGLLLYRTAGGRVEVLLGHMGGPFWARKDEAAWSVPKGEYEPDEAPEAAARREFTEELGLPAPEGPLLPLGEVKQSGGKTVTVWAVEGDLSPADVVPGTFGLEWPPKSGRIQQFPELDRVGWFDLDTAREKLVKGQRTFLDRLGESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN38</accession>
    <name>A0A010YN38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter substrate-binding protein, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851011.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2695"/>
    <dbReference type="HOGENOM" id="CLU_027128_4_3_11"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458123" evidence="3">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="35"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="42375" checksum="2D660273143585E7" modified="2014-06-11" version="1">MGRRTLPLLALVCSVSLALAGCGGGSTGTGDSGGTIKIGTLHPLTGPFAGDGQQMENGVKLAIEDINKAGGIKALDGRKLELAGGDTQGKPDVGQSEAQRLVTEGVTALVGTYQSAVSANVAPLAERNKVPFVIDISGDDGILSHGYEYAFRMQPRNSVFGTAGAKYLQEISKAAGKPLTKVAYLHESTAFGTGVFKAFKAEAEKAGITVDPEISYDAASVSDLTTQITQVKASGAQALVVTGYYKDGVLAAKAVSTVKPTLDAVYGIANGAFDQPQFPTDAGAASAGYFDVNYHLNDKSPEATKFAQAYQAKYGQPPRTGAALAYDSVRVIAAALERSKSVDGSKLRDAITDTDLTPLTLNDGPIKFDDKGENSTALPALTQVVEAKPTVVYPAEFATAKVTYPAAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNP7</accession>
    <name>A0A010YNP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851220.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2862"/>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="18147" checksum="B924A87A19ADF22E" modified="2014-06-11" version="1">MTSDGESFDSYVAAEGAALLRFAHVLTGDHHLAEDLVQEALVKAHRRWSRIDRPGAYVKKAVLRQYLSWRRRRSSGERPTDATLEGTAAQRDVAEQVTDRHALRGLLATLPRQQRAVLVLRFFEDLDDATIAELIGCSATTVRAHASKGLSRLRRSAQTVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP66</accession>
    <name>A0A010YP66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851494.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3067"/>
    <dbReference type="HOGENOM" id="CLU_1531296_0_0_11"/>
    <dbReference type="OrthoDB" id="1728559at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="18919" checksum="277507448218E91A" modified="2014-06-11" version="1">MSTPDIPAHLVGCPRSGGLVVPWVTPSTREGIALFGQLTDLAVAVCLLEECCQICGNRLLDRAVLFARESDLRLQCTPEPPVCPPCAAYSIRACPMLAGSQTHYRATTHPALAGTPPTTGALLRQGASAEPWHAVWVRIYDVINHPILPETLAASWRRIPPLRIRPVTTGRGQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ23</accession>
    <name>A0A010YQ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HhH-GPD superfamily base excision DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570401.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_5_11"/>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="53"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="23759" checksum="3CEE49CCD8C3BAB1" modified="2014-06-11" version="1">MDLRSNRHYRELVAAEPRFARLVDLYGEVDPFRWQDSDEPDRSKFAAMAFHIVGQQISVRAAKTIFGRLAQRAGGEVTAARLAELEIVELRAAGLSGAKARYLNALAHAQVEGRIDLEHLDHLSDGEAITQLVAQPGIGVWSAQLFVLHQLHRPDILPAPDLWIRRGVQQLMELPAEPTVKETIALGLPWSPNRSYAAALLWSITKPPPQGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ27</accession>
    <name>A0A010YQ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863545.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3389"/>
    <dbReference type="HOGENOM" id="CLU_051715_3_1_11"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="29067" checksum="6997D11ADFFECFE0" modified="2014-06-11" version="1">MTAPGIPVVFIHGLWIHSSSWTPWVELFHAAGYQPIAPGWPGDGETVADTRARPGRLAGVGLEDIATHYRGIIEDLDRPPIVIGHSVGGTVVQKLNLTSDLCAAVVLNPAPIKGVRALPLAQLRSSFPVLRSPGNQKRVIALSAEQFRYGFGNTLTADESDELHERFAIPGPGRPLFEVATSNFRSSSPAAVDTRTGQRAPLLFVSAERDHTVPDVVTRAAHRLYRDSPAVADLIQLPGRGHSAPFDHGWADVADQVESWVKRQVVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQC9</accession>
    <name>A0A010YQC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="24025" checksum="8B2D66279C55F35B" modified="2014-06-11" version="1">MKPTIVLVHGAFAESASWNGVISRLQAAGHPTIAAGNPLRSLSGDAASVASLLATIDGPIVLVGHSYGGAVASNAAVGNDNVKALVYVAALAPDKGENVPDLTGKFPGATLGDHLREVPLGDGTADAFVVPEHYHEHFAADLTAEEAALAAATQRPFNSNAVTEASAEPAWKTIPSWFISPELDRAIPLEVFRFMAARANAREAVEVPGASHALPVSQPQRVADFILQAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQG3</accession>
    <name>A0A010YQG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852240.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3579"/>
    <dbReference type="HOGENOM" id="CLU_069356_25_6_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21571" checksum="12B310BB58F7764E" modified="2014-06-11" version="1">MGDGHHGNRHGRSEAAREAVLEAADDLLTERGFAGVTVEGIAARAGVAKQTIYRWWPSKVDILLEALGSDLAQHLTPADRGPIAEDLRAHLRALARFLTRSDPGTVLRALVGQAQHDPELAARLRSEQLAPQRERETERLLRAVEAGELPADLDPGSAVDQLVGPVYYRVLVTGEAVLPAFTDALVDGFLRAHGSVEKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRA7</accession>
    <name>A0A010YRA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852657.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3894"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_11"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="35916" checksum="6C5F8DBB79321361" modified="2014-06-11" version="1">MAARQRVAEHLNGALGAALAADDRLYLLGQDITDPYGGAFKITRGLSTRFPRQVVATPISEAGLVGLANGLALAGNRAIVEMMFADFVTLAFDQIVNFAAKSVSMYGQRVPMPVVVRCPTGGRRGYGPTHSQSLQKHFLGVPDLDVYEISPFHDCVDLFAGVLRRGVPAVVFEDKVLYTGLRRPPGTADDLFRYDLAGPWPGTAVARIAGIDTPDCVLITPGGVAERALVAMRELLISREISCELYVPARLDATALEPILPAAARAGQVVIVEDGTAGGTWAADLAHQLHTALWGQLSRPVRVVCAADRVVPAAAHLEEEVLVQAATISATVQRGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRC1</accession>
    <name>A0A010YRC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3911"/>
    <dbReference type="HOGENOM" id="CLU_017436_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="583" mass="62093" checksum="01BA5ADCB802F562" modified="2014-06-11" version="1">MSESPDLASYRRRRERELSALYATARSLTALGELDAVLESIVREAHELVGTDFTYLSLVGPDGKLTLTASQGTISPTFHEASVPSGTGVGGRVIATGAPAWVSNYLQTRDVPHDRTFDGLVVPEGMVALLGVPLLVGEEVIGVLFAADRTERPFEHDEVALLSAFADHAAIALNNARLYDESRSALKQLQAAYRTIEHQVAVTERAQAVHEALTRVVLTGGGADEIARLLVEHLRGEVTVFDRAGAVTARCALGAAIGPSPADVVEQARRTGRWATATDDAGNWHSAATVQAGDTHLGALLLARAEEPSPLDLRTLERAAQIMGLLILKETAVAEAEERVSGSLLTELLVSAAPVGPAQRARASARGVDVTALNVVVVAASDTRPAADLSRRLHAMSAQWRGLAGEHLGRAALLAVTSDPAGLAETIHGRLRRELGSAVRVVAEASGADDWGRAFEIAGRCCDLMPSLGATDRGSTTEPYALFASLFDASRAPGLDRFLADALQGLLTYDARKSTQLVATLSSYFEHSGNLTRTAAALHIHLNTLLKRLERVTSILGDDWRSPDRALPLQVALRLHALRSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVA7</accession>
    <name>A0A010YVA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569538.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.101"/>
    <dbReference type="HOGENOM" id="CLU_016609_2_1_11"/>
    <dbReference type="OrthoDB" id="397852at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="59"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="547" mass="58202" checksum="476A2150AFFCB40B" modified="2014-06-11" version="1">MTLLARATDESGLSRRLSALDRVVELGADRLDPAVLATAGALSGKAAERLRLGAEHTVVALAGTTGSGKSSLFNALVGVDVAATGLRRPVTSTAQAAVWNPDGAAPLLDWLGVKRRHHLGDEGADALSGLVLLDLPDVDSVQVDHRLEVDRLVKLVDLLVWVVDPQKYADSALHDRYLQPLRTHADITVVAFNQIDRVPPARRDEVLADLRGLLEREGLGGVPVLPVSARTSDGLPALRTRLADAVAAHEASVRRLNADLRALADELGPTCGPSATPAVERADRAAVVGALTEASGADAVALAVARTHRSRTRAATGWPMTRWLARVRPSAATRLGLPGARLSPGEAEDELVRTALPGPSAVQQARVDTALRNLVDRTTAGLPQPWPSVLTRAATGRRDQLPDLLDRAVAGADLGLGRRPRWWGVVRLLQNVLALVAVAGVGWLLGLFLLDWFRLPEPPLPDVDVWEWRIPVPTGMLLGGVLVGLVLGFLSARLGALGARRQAAKARKRIRARVEQVATDAVLEPVSAELSARSELCAAISQLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVN5</accession>
    <name>A0A010YVN5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CryarDRAFT_0226</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847705.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.213"/>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_11"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="267"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="349"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EXG79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="421" mass="44019" checksum="04E5EB0EF7B1A0DC" modified="2014-06-11" version="1">MGLVVQKYGGSSVADAERIKRVAERIVATRKAGSDVVVVVSAMGDTTDELLDLAGQVAPVPPGRELDMLLTAGERISMALLAMAIHSLGYEARSFTGSQAGVLTTARHGAARIIDVTPGRIQGAVDEGAIAIVAGFQGVAQDTKDITTLGRGGSDTTAVALAAALKADVCEIYTDVDGVYTADPRIVKNAKKLETVVYEEMLELAACGAKILHLRSVEYARRYDIPIHVRSSYSNKPGTIVAGSMEDPSVEQAIISGVAHDRSEAKITVVGVPDQPGIAASILRTVADAEINIDMVVQNISAAATARTDISFTLPKADGPAAMAALQKVQPTIGFDRLIFDEHIGKVSVVGAGMRSHPGVIASFCEALAKVGVNIEIISTSEIRISAVCRDTDLDAAVRAVHEAFELGTDEEATVYAGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWI2</accession>
    <name>A0A010YWI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569640.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118706_0_0_11"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="25544" checksum="6AE08B0A7B9F9A1E" modified="2014-06-11" version="1">MPGRHSSSAETTELIYVAEEAPRGKHTRNRGRRRRENAAGRAAKVAFAGVAAAAVAGSISYGAVSMVTRTSDAGSPSALAAPARAGDDRASRSGGNCARTGPGQARVEQYLSGQTARFGPITMDASQDASDCAAIKKFQAAVGLTTVTGFADEATAQIADRLYQSTAAACGADVDATTVCVDLSHQTLWVMKSGSVVFAPVVVRAQDAAAGESTITADFQQQFHVNLLDDDARKVADLAPAGATVHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYA7</accession>
    <name>A0A010YYA7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Uricase</fullName>
            <ecNumber evidence="5 7">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 7">
            <text>H2O + O2 + urate = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849001.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1245"/>
    <dbReference type="HOGENOM" id="CLU_048151_1_0_11"/>
    <dbReference type="OrthoDB" id="1150949at2"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="PTHR42874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="30270" checksum="8B102C9204A940DE" modified="2014-06-11" version="1">MTFTLGPNQYGKAGVRLVTVDRSSDRHVVTDLTVASALSGDLEGTHLTGDNSAVLATDTQKNTVYALAREFGVGEPEAFGLRLGRHFVATQEPIRRARITIEQHQWERFGEHSFARSGAETRRARVIVTEDETRVSSGLGDLTLLNTTDSEFHGFPRDSYTTLPETTERMLATSVEAWWDHGSSDVGWGRAYTDARAALLAAFAETYSYSLQQTLFAMGSRVLTDCPSVDEVRLALPNKHHHLVDLTPFGLDNPDQVYVAPTEPYGLIEGTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ09</accession>
    <name>A0A010YZ09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849346.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1506"/>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="213"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="36435" checksum="08FD4CB49BB1FEDF" modified="2014-06-11" version="1">MAPDLITKARNGDNDAFRELTGPHLVELRVHCYRMLGSFQDAEDALQDTLLAAWRGLGGYREHASLRTWLYRIATNQCLNARRAAGRRPVAEWAPPVADAPQPTGLSDTVWLQPFPDALLADVAGPEARYEQTEAVSLAFVTALQALPPRQLAVLVLRDVLGFRADEVAEMLDSSVESVKSALKRARATLGHRRATEDPPAPGSATEDAITARFVEAWESADVDALVALLTEDVFISMPPTPFEYQGRELVTRFFARIFATGRRFDLVPTRANGQPAFGAYLRTPTGISHGTGLYVLGLAGERIDALTRFENTVLPWFGLPRSVDRDVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ26</accession>
    <name>A0A010YZ26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849382.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_2_1_11"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="272"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="796" mass="81034" checksum="A20AAE15E304D1A8" modified="2014-06-11" version="1">MLTVALSTLRSRWTTFVTTVLTLTLGVALIAAAGVVIAGTVTAPDRPPRRYAAAPVVVTPRDELRVPTANGVQVIPLAESRGLRPEVVARVTGLGPAVIDRIFPAGLAGSEPGAVGRPWAAARLGNYRLVTGRGPRKATEVVVRDGVAGVGVGSAVTVLTAAEIRVYRVVGLTAPVPFEQAIFFTDAEAARLSPRVDAVASGAAPAAVRAALGDDARVSTGARRRALDPDHRADTEALVAANAIVGTAAGVSGFVAVFVIASTFAYAVATRRRELALLRTSGATPGQVRRSVIAEGLLLGVAGSAAGCALGGPLARGVAVWLVDNGLAPPWFTVPDPRWPFVVASGAGVLTALLGVVAAAHRAGRIRPVEALRETAVGTPMTPGRWIFGLVTFSGALFMLVEPVVAAPAAALGRKHYLPATMLLLVAIALLAPLVVPPLARLLGTLTGLLARQAALTAARRTAAMAAPVLLTAGLAGGVLTVTATIDAAKSAEREGLAVSSELGLDPDAVARVRAVPGVASVNVVRPTVVYAADDDAAVVRHTARAVDRVTGVPVLAGDPSALDDQSIVVDAEFGWSVGEHVQVWLADGSPRSFRVVAVVREGVGGNGAFLSGRHAGTAVASRVEVSVAPWASRAEVSRAIEAAVRGRGELATTRTSRRAQTLGLQVILGLATVLAVLSIVGTTLMAARDRRGESELLGLAGATPLQVVRAVCAEALLVSALGLVLAAAATVLSSAALWLCLWQLTGGPLPVVVPWGPVTTVAAVCVGVTVVSALVPALWTLGRASTKRRAPASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ55</accession>
    <name>A0A010YZ55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849428.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1561"/>
    <dbReference type="HOGENOM" id="CLU_097806_7_6_11"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="104" mass="11176" checksum="4236C968B84962F7" modified="2014-06-11" version="1">MTVGPPPPDGVTQRLQPASDLLRALAAPIRLGIVRELAEGPKPVHALVAALEASQPLVSQHLRILRGAGVVEAHRRAREIEYSLVDDHVAHIVLDAIRHADEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZQ6</accession>
    <name>A0A010YZQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation elongation factor EF-G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569941.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1738"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_11"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="2"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="646" mass="67825" checksum="AAF632A18FBAD2DB" modified="2014-06-11" version="1">MRTVRNLGILAHVDAGKTTITERILYATGTTHKRGEVHDGTTVTDFDPQERDRGITIFSAAVSCVWNDHRLTLIDTPGHVDFAVEVERALRVLDGAVAVFDGVAGVEPQSESVWRQADRYGVPRIAFVNKLDRAGADFDATVESIRTKLDAVPLVVQLPIGREDGFAGVVDLVAMRAVRWPEEDGPVVGPVPDGLLADAAARRRQLVETVAERHPAALAEFPDVSDATLVAALRDLTRAGAGVVVLGGSAYRNRGIEPLLDAIVAYLPSPSGEAAAPLAALVFKVAVTATGRLTHVRIYSGTLEKGDTVLDAATGRTERVGRILRVQADRHTEVPRAAAGDIVALVGPKAAATGATLCAPDAPRLLEPAASVDPVVSVAVEARRGADTQRLATALSRLVAEDPALRVRTDRETGQTLLSGMGELHLEVAVEKIRRDSGLSLGVGRPRVAHRETVVTGVSGFTYRHVKQDGGAGQFAVVTFDVEPGADGFSFESAVVGGAVPREYVRAVEAGCRDALAEGPVGGSPVIGVRVRLVDGATHAKDSSELAFRTAAERGLRAALRACVVSVLEPVVEMTVTVPADAVGGVLGDLAARRGRVVDSVARGSTIVVTAVVPLAELFGYATKLRSRSQGRGTFTSRPNGYAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0R5</accession>
    <name>A0A010Z0R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725889.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2104"/>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="29313" checksum="831A07127A3EDF63" modified="2014-06-11" version="1">MNEADATDRPNPAGIYDYILGGTANSAVDRAAADRALKVLPELGESAWANRGFLQRAVARMADEWGVRQFLDLGAGLPTQRSTHEVLAEHCPDGRVVYVDRDPLAVERGDVLLRGIAGATMVRADIRDVEQVLSAPRTRELVDLELPVGILLVAVTQFLPDEDDPWALVRRYVEAVPPGSYVAISAPTSDKQSERVVGNVRSEMARAGARAVSRSRAEFTRFFEGLEIVPPYPGAEPVVVHVGQWGAEDPEVADDDGSRWFYAAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z127</accession>
    <name>A0A010Z127_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ORF">CryarDRAFT_2243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850330.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2208"/>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_11"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="59"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="319"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="311"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="461" mass="49458" checksum="DD03E1A638A5633C" modified="2014-06-11" version="1">MTLPELLPSLRTSLSTRFAPEIWPLTTRPGRHGDLLVGGVSLRAVAEQFGTPTYVLDEADVRTRCRRYTRAFGTGDTEVAYASKALLCGTVARWIAEEGLALDVCSAGELAVARAVGFPPERVVLHGNAKTAEDLRSALDYRVGRVVIDSVSEVARLAALATTPQRVLLRVIPGVDAGTHSALTTGVEEQKFGLSLTTGAAADAARRVLGQHALALTGVHCHIGSQVSRFGGYERALSQLVTFLAWIRDERAARGLPEQGPAELDLGGGHAVPYRHGDDDFAIEGFAHRIHQVLTLECERHRLPLPRLTVEPGRAIVARAGVTLYRVITIKRTAAGQRLVAVDGGMGDNLRTSLYGARYTVSRVGQISSAPTTAATVVGRYCEPGDVIARDVPLPDDVRPGELLAVPGTGAYHHSLANNYNMVGRPPLVVVRDGEAHVAIRRETIDDLLLRDAGCRPETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z132</accession>
    <name>A0A010Z132_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850340.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2212"/>
    <dbReference type="HOGENOM" id="CLU_000445_113_1_11"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="616"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="840" mass="89587" checksum="0E0580F328DBD08D" modified="2014-06-11" version="1">MGRGVLRIYLGAAPGVGKTFKMLEEGRRRAERGADVVVGFVETHGRAETAAQIRDLEVVARRSITYRGAQFEEMDLDAVLARRPEIVLVDELAHTKARGGKRWQDVEALLDAGIDVLSTVNVQHLESVNDVVQTITGVPQRETVPDAVVRAADQVELVDMAPDALRRRMAHGNIYQADKIDAALGNYFRVGNLTALRELALLWTADKVDEALRRYRDEHDIHGVWEARERIVVAVTGGPEGDTLIRRAARIAARSQTGDLLAVHVSRSDGLADVDPARIERQRDLVEDLGGTFHAVVGDDVPSALLDFARGANATQLVLGTSRRPRWQRALSEGIGTQVVAASGPIDVHMVTHSQAAGARRPHLPRLTGGLTARRRWYGFAIAALGLPLLTFVLTLAEGHLDLSSELLLYLGAVVAVALVGGGYPAVFAAAVGTLLVNFYFTPPVRTFTIAEFDNLIALAVFILVALAVAAVVDLSARRARQASRAQAEAEMLSALSRGVLNGERALDALLTQVRDAFGQDSVTLLERVDSRWNVVGCAGAVPCADIDEGDTDMPVTDTLHLVLRGRRLAASDRRVLAAFAAQAVVAMRQARLSAQAAEAAELAEGNTMRTALLAAVSHDLRTPLASIKAAATALRLPTVTLDAEDVDELHATIDESADQLGGLIDNLLDMSRLQTGGINPLRRTVSLEEVVPGAIAGADRRNGWPAPEIRVEISEALPPVRTDPGLLERALANLVSNAVRHGAGAPVAIRASAHADRVEIRVVDTGPGIPEPDRDRIFAPFQRLGDRPTGNGVGLGLAVARGFVETVGGTLEPEDTPGGGLTMVVSLPTARPAVPVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2D0</accession>
    <name>A0A010Z2D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deacetylase, histone deacetylase/acetoin utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850954.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2662"/>
    <dbReference type="HOGENOM" id="CLU_007727_8_2_11"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="44"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="365" mass="38828" checksum="D96344319FD9464D" modified="2014-06-11" version="1">MATGWVWSERYMWHDAGTAGGPLPVSRWVEPMTHIEGPDAKRRFANLVAASGLLERLTVLAPRPATVAELTRVHRRSYVDEIARQAAAGGGNLGGGTPFGEFSYEIALLAAGGTITAVEAVVGGTVENAYALVRPPGHHATPEHGRGFCLFNNIAVAARHAQATLGVGRIAIVDWDVHHGNGTQDTFWDDPSVLAVSIHQDGVYPPRSGPVTDTGAHGTIVNVPLPAGSGDGAYRAAFADVVEPALDRFAPDLILVACGFDANGFDPLARQMLSSESFRWMTGRVKAAAERHCEGRLVLTHEGGYSPFAVPFCGLAVVEELSGVRTEVEDPFLPIVENYGGRLLPHQAEAIARAQRNDTSWASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z399</accession>
    <name>A0A010Z399_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2968"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="36438" checksum="AA5B2B5ED8BA8B10" modified="2014-06-11" version="1">MALTPLLSGPAVGDAGVMTRIAINGFGRIGRNVLRAMLERDTKLDVVAVNDLTEPAALARLLAFDSTAGRLGRPVTAEGDELVVDGRRITVLAERDPANLPWASLGVDLVLEATGRFTSAKAARAHLDAGARKVLVGAPSDGADVTLAYGVNTGAYDPAAHTIVSNASCTTNALAPLAKVLDDLAGIEHGFMTTVHAYTQEQNLQDGPHRDPRRARAAGINIVPTTTGAAKAIGLVLPNLDGKLSGDSIRVPVPVGSIVELNTVVARDVTREDVLAAYRAAADGPLAGVLEYSEDALVSSDITGNPASSIFDSALTRVDGRHVKVVAWYDNEWGFSNRVIDTLELLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3D3</accession>
    <name>A0A010Z3D3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain-containing surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3002"/>
    <dbReference type="HOGENOM" id="CLU_810662_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006637">
        <property type="entry name" value="ChW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07538">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00728">
        <property type="entry name" value="ChW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="34954" checksum="EB36035EBD989B7E" modified="2014-06-11" version="1">MTLDGAARLRVIRPLSNKESAPVRKGTRLSAKPDESAPDQVTEGPTPEPEAATEVVTTPDAVTEDLSDYPRPSSQWLMVGSPQPPAEPPVFEEPAPTSPDAASGGRKRRAGLALGLAAVLLVAITVATTLWLVPDHGTASARASAPAPRPLTSRTHASPSPSATASSAATPAAVKSAAPRPSSRSSAGAAPQPAPVASPPSAAPAPAKICARGHVENTGWQPWVCAPHGGRLTVGRVGQSLRLEAVEVYTVGAGGVCLTAHEQDSGWQGQLCQADGTPVVAGSTGQSRRMEALRIRTGSGVCARGHVQDIGWQARACAPPDTVVQVGTTGQSKRLEAVELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z482</accession>
    <name>A0A010Z482_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2842419_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="65" mass="6764" checksum="D1760A95504F67C5" modified="2014-06-11" version="1">MGVAEGQLVVRATAAQGLKDRVTGNGNVNFAVAGGVQDAVPFRQTDGDVSKVGVVWRMTERSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4V4</accession>
    <name>A0A010Z4V4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570481.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3514"/>
    <dbReference type="HOGENOM" id="CLU_028723_10_0_11"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="16651" checksum="CE5093891EB96725" modified="2014-06-11" version="1">MNIVAALAPIGGVLAAAVWVRRNLVVVRVTGFSMEPTYRSGDRVLVRRCHVSAVRAGQVIVILAGKRLGGPPPIDDPFWVIKRVAAAPGDPVPRTRVPALGAVAEDVVPDDCLVVLGDNPAGTDSRQFGYFAGGNLLGAVVRPRAQRRQSARICCGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4X8</accession>
    <name>A0A010Z4X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852179.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3547"/>
    <dbReference type="HOGENOM" id="CLU_069088_0_0_11"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="27303" checksum="3617332F6E02043F" modified="2014-06-11" version="1">MSDDVTRAEICVIACADAWRGAGEVLAHAVGTVPTISARLARLTHSPDLVLTDGEAFLMSEPPPLGGTAATGGQIEGWAPFRAIFDILNSGRRQSMMGASQIDRYGNQNISLIGDWDRPKRQLIGARGAPGNTVNHRTDYWVSRHSAKVFVEHVDVVCGVGNDRARAHPSGSLKYHDLGVVVTNLAVLGYDADGRLEVRSLHPDVTAEEVKANTGFPIDCSDAPPTRQPTPDELRLIRAVIDPEGLRDREVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z512</accession>
    <name>A0A010Z512_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3583"/>
    <dbReference type="HOGENOM" id="CLU_069356_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="20552" checksum="4C188B918DAB491A" modified="2014-06-11" version="1">MDALETRAAILRAAADIASVDGLEGLSIGRLATELSMSKSGVLGQFGSKEELQLETVRLVLANFVARVWEPARHLERGLPRLTGVCEAWARYAMAPGYPGGCCVATFSHEFDGRPGRVRDELAGGVRQWRATLVREITTAIGNGDLPPDLDPHQAAFTLDAIASGVGPARLLHGETDAGTWAAHAMRAALRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5A5</accession>
    <name>A0A010Z5A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3684"/>
    <dbReference type="HOGENOM" id="CLU_110158_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="20079" checksum="D0B03BE49F6FD5F8" modified="2014-06-11" version="1">MTLSGTQTAILAAYAELIEELGSDDVSFRVIARRAGIAQRTVFRNYPTRVDLLLATAAWIEATLFARDELDSIFDVPLAIRDAMQRYDARPELAHVVAETAMRGVSGAAPAPGRAQLERLLDAEVPSLDAAQRRSVVAALSHLDSVGTWVTFRREFGMDQRDIADAAAWAAEAVLDTIRDRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5B1</accession>
    <name>A0A010Z5B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852401.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3690"/>
    <dbReference type="HOGENOM" id="CLU_017261_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="830" mass="90186" checksum="D9AAB76A4F5DC0FE" modified="2014-06-11" version="1">MSTIDYGIDLGTTNSAIAALSGVDTRIVKNNDDQDTTPSAVWVDRRDRVFVGRAARDRAEADPGNTCTEFKLRMGTAGAEKHFAAGGRTMSPEQLSAEVLRSLRADVHQRDGVELDAAVITVPAAFELGACEATRRAAALAGLRTTPLLQEPTAAAYAYGFQSGEDARWLVYDLGGGTFDAAVVQLRDGEFTVLTHRGDPFLGGKLVDWRIVETLLVPAVAAEFGLDDLSRGNPRWTAVLSRLKLAAEAAKIRLSRAPSVDVLLELDLGEPGRHEFEFEVHRADVERLTEPYLIRSVNLCRQALADSRLAPDDLARVLLVGGPTLSPYLREWLADADHGLGVRLDHSQDPITAVARGAAIFAGTQRRPGPAPVPDVPGARLRMAVEYAPIGPDTEPLIAGRLLPAGEDRTPDLVGHRVELISDDPGAVWRSGQYPVGPDGFFAVPAWAERGRRNTYRITVTDPAGTPIDVPHDPITYTVGIVETSPLLTNSIGVGLEGNTRQWLVRRGTPLPAYGRVTLRTAVDVGRGGHGGVLRIPFLEGEHARADRNRQIGRLEVVAAQVSRDLPEGSEVQVRLEIDASRLITARAYVPILDEEFEHVVRLGTETAPAHAVLSAELEVERRRLAAVRQRQRDVASPVAEIDLFRIDDERIEPEVAALVDAARADPDAASAAGRRLLDLRAAVDAVEDALEWPELVSGVEQAIEEVRRLVATDGDAGDRRRLDELSATARRAVDDRDPRLLRVQFSELAEVAVTILDRSGRLDVMVFEDLARRRGELLDRAQGDALLERGRQAVAGGDHATLRNLNVRLRGLLPVPPPPPDPFSTVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5F2</accession>
    <name>A0A010Z5F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3732"/>
    <dbReference type="HOGENOM" id="CLU_017290_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="117"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="456" mass="50354" checksum="3936CBCFD5A6A713" modified="2014-06-11" version="1">MSDQILAAAGITGDVHTVIVATPDLQGRLVGRRIPIEGFERAVEEGVDVCTCVFAWDLTQSLELVEANVFALCGVHNGIPDFTLVPDLSTLRRAAWLNGIAICFADAVDKHTREPLALSPREILKKQIAELTTSGIRARTGTELEFYLFLNAPRALRQAGFRGLEPTTLTPSDFMIHEGNHYEPFFHRLRTDLRDSRIEMEAAQSEWGSGQWEMTFRYGEPLEMADRHALYKLAVRDSAAAAGMSATFMAKPLNDGQPGSSCHVHVSMVDLDGRPTFWDPSAEHGLSATMRHAIGGVLEHAPDLMAWYAPTVNAYRRVNSGDVAGWGSAWGLDNRTTSVRVVGRREQDLRFEFRLPGADTNPYLTLAGLLASAHQGILDKTNPPPMTTGNGYDTPVDPAFPSNLGEAAARLRRSAFVAGAIGEEQRDHLAVLADHEWRTFMSHTSDWDLDRYFDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5G1</accession>
    <name>A0A010Z5G1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852471.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3742"/>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="20423" checksum="D26D142E8334F763" modified="2014-06-11" version="1">MGKAQSRPGGGRERLITATVGLLSRQGYEATVVKQITTEAAAPMGSFYFHFPGGKEELALAALERGAEGVDTLLAETLARAAAPVDALADCALALADVLARSEWLDGCPVAATALESIGRSPALRAAAAAAFERWVGTLERHLVRAGVAAEPARSLATTTLALLEGAEMLARVRGSAEPLHDAAAALRVLARTALAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5Z4</accession>
    <name>A0A010Z5Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
            <ecNumber evidence="2">3.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29408" checksum="FBD58870A236C7EE" modified="2014-06-11" version="1">MSTIVYDGFRFPEGARWRDGRLWFSDMHTGEVFRADPVAGTPPETVARIDDQPSGLGWSADGSLLISSMTRRLVVRVDPDGVHGVFADLSGFTDAPINDLVVDGDGRVYVGGFGYDLYGDAPQRPGPIFVLEPAGDARVARDDLVFPNGSVVLPGSRTLVVAETWAARLTAFTITGDGDLVDRRVWAPLPAGATPDGLCVDAEHGVWVADISNGRFLRVTEGGEVTDEIDVGDRAPADCVLGGRTLYLLTANSWQPSETGIRAGRVEAVEVSVPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6Q1</accession>
    <name>A0A010Z6Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacid CoA-transferase, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853123.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4169"/>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_11"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26572" checksum="B30480D70B22B30B" modified="2014-06-11" version="1">MHKVVESAAAAVADVPDGATLSVGGFGLCGIPSVLIQALLEAGTRDLEVVSNNAGVDDWGLGVLLGAHRLRRIVASYVGENKEFARQYLAGELEVELTPQGTLAERMRAGGSGIPAFFTVTGAGTQVADGGLPWKYGSDGSVLVASPPKETREFGGREHVLEEAIVADFGLVRAWKGDRHGNLVFRRAARNFNPLAAMCGRVTIAEVEHLVEPGEIDPDDVHTPGVYVHRVVALTSSQAAEKRIEKRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL27</accession>
    <name>A0A010ZL27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080601_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458338" evidence="2">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="27669" checksum="988434F053F0F3A4" modified="2014-06-11" version="1">MRATPARLSARRLRSFSCCERATRAGLPSRTGTCVTPGRYSCLVPVWPAAPLLASRPRGYSRRTRGDTPKAARVAPVWVPASRLCGYRPRACVGTGLAPVWVPASRLCGYRPRACVGTRDHDPQRALVPSSHGYLCRACMATVAPAQPTVSRPSALLAAQLHASRQRGHLRYYAPSSRGFPRCARAVSALRPRGCPSRVGTPIRVGRPPPLLTVSPSLPPTRPPRARRTSLCPCDPGGETITSPPGEARGSRCPMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL83</accession>
    <name>A0A010ZL83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.438"/>
    <dbReference type="HOGENOM" id="CLU_036192_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="488" mass="50248" checksum="903579E706CD748A" modified="2014-06-11" version="1">MSSFRPTPPKSSTVLGANEVEKSSLTLLSGEPTVVTAGVDLFADALTAQAAAVTPVAWQPPVGAEDALARVMADRRRLSANRTALERMLAAGASLVDVRPASEVVGLTAGQFRHAGPPITWERASGPMRGALIGATLFEGLATTAEDATNLLSGGSVEWAPCHSDGGVGPMAGVVSPSMWVFVLRDEAHDRTSWCSLNEGLGKVLRYGAYGPEVIDRLRWMSSVLGPALRAAVREHGPVDVKGIIAQMVQMGDEGHNRNRAGTLMLLRDLMPAMIDAGVASSDVADVARFVGGNDHFFLNLVMPACKLQTAAASGIPGSTVVTTMARNGTDFGIQVSGTGDTWFTGPANTPQGLFLGSYGPDDANPDIGDSAITETAGIGGFAMASAPAIVRFVGGTVPDALRTSREMYGITTGENPAYALPILDFRGAATGIDVTKVVRSGVLPQINTGMAGRVAGVGQVGAGLVTPPMECFTAALDALGEAAPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLA0</accession>
    <name>A0A010ZLA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">CryarDRAFT_0474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848086.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.458"/>
    <dbReference type="HOGENOM" id="CLU_023643_3_2_11"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="251"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="30059" checksum="F97E44DADD8474BD" modified="2014-06-11" version="1">MGTVTLTVPDTDLITLVRDGDVVVLSGAGLSTESGIPDYRGPSGAFKRNHTPMTYQAFTRDVVARRRYWARSFLGWRMISRAEPNDGHRAVAALQRNGLVGSIITQNVDGLHQAGGADRVIELHGSLDHVICLDCGEHTPRLELDDRLRAANDGFGHDFDPDTVNPDGDVDLPEEHLDRFTVVDCTGCGGVLKPDVVFFGESVPKERVARCQQAVAEAGLLLVLGSSLTVYSGRRFVVQAKQAGVPVAIINSGPTRGDEHALVRIDAPLGSTLTALAAATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLW3</accession>
    <name>A0A010ZLW3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569686.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.676"/>
    <dbReference type="HOGENOM" id="CLU_069356_21_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="22637" checksum="B58F907BB99EE8E1" modified="2014-06-11" version="1">MVRASSGNRRADILDAAIDLVAEAGLRGLTHRAVDAAAGLPEGSTSAYFRTRAALLTAVVVRLGERIGADVDELADEAARHPGDTTHAIEETLKQLDCWLSDPAPLLARLELSLESTRRPELGEAMNNWRTAFEALVARMLDDVGLSKASERATLIVACMDGILLRALTSAPADEARRTAVDEARTLLTSLLISAQVLDSGQDPLTDVMPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM42</accession>
    <name>A0A010ZM42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">CryarDRAFT_0773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848498.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.760"/>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_11"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="55" mass="6476" checksum="FD121586C873222C" modified="2014-06-11" version="1">MAKGNELRPVVKLRSTAGTGYTYVTRKNRRNDPNRLTLTKYDPRAGRHVEFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMY7</accession>
    <name>A0A010ZMY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">CryarDRAFT_1115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848832.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1095"/>
    <dbReference type="HOGENOM" id="CLU_108953_2_1_11"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17725" checksum="AE1E783C2ABA5AD4" modified="2014-06-11" version="1">MPRETGRKVIASNRKARHDYAVLDTWEAGIVLTGTEVKSLRAGRASLVDGFALVDDGEVYLHGVHIPEYVAGTWTNHAPRRVRKLLLHRAEIEKLIGKIKEGGLTLVPLSLYFSDGRAKVELALARGKKAWDKRQDMAKRDADREIAKAYGRNLKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPF5</accession>
    <name>A0A010ZPF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849499.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1614"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="24819" checksum="B805C528BB7C5417" modified="2014-06-11" version="1">MRLLVVEDEEDLAEGLRVGLTRTGYAVDVAVDATEAYDRLTVNEYDLMLLDVNLPDGDGFELCRSVRAGEAGNGDLRVLMLTARGGLDDRVRGLDEGADDYLVKPFHLAELQARIRALLRRDTNGTTARLVVGELVLDTARHTVALRGKALNLTNKEFGVLEYLMTRPGHVVSSEELLEHVWDANADPFTQTVRVTVGTLRRKLGEGSIETVVGRGYRLREEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR12</accession>
    <name>A0A010ZR12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR02611 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2178"/>
    <dbReference type="HOGENOM" id="CLU_1719286_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
        <property type="entry name" value="Uncharacterised_PGPGW_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09656">
        <property type="entry name" value="PGPGW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02611">
        <property type="entry name" value="TIGR02611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="152" mass="16953" checksum="3C19AD96A0FD267C" modified="2014-06-11" version="1">MIDTQERPPEAEPTLVDRLRAHPLALRFVAWGVFFRDRMHHPMRSHPVFGFPYRAAITVVGVVVVILGLIMVPAPGPGWLVVIAGLGILSTEYSWARRLLHFTRGAVAAWTRWVLRQPLVVRMAVGFAGFLLLVGCLLVSLRLSGWTGFPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR80</accession>
    <name>A0A010ZR80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycopeptide antibiotics resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2242"/>
    <dbReference type="HOGENOM" id="CLU_090667_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="133"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="22742" checksum="CB271353924F7152" modified="2014-06-11" version="1">MHWDGVVNHSATLSARRRVVLLVATIAGLVVVLRRPLTMSAPRCLTGHWHGCYDTENGVLLMTLLGVPVAALVAWVLARARRAPTVVSVAEVGMVYGTVPFLWLALMPGPGAGTVPGRVSLVPLLDLVAMGPLGIAGNLLIFAALGFFAPMRFAALASVPRVLALGAACSALVETAQYVLRLDRVSSVDDVLVNAVGAALAALVSRPWWRDRQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRF9</accession>
    <name>A0A010ZRF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dyp-type peroxidase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.800"/>
    <dbReference type="HOGENOM" id="CLU_337629_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459215" evidence="6">
        <location>
            <begin position="27"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="843" mass="87465" checksum="646DAF499CBF4BBF" modified="2014-06-11" version="1">MWLRRVAVIGALVTALLAIGAGPAAAHTVGGVGATNFRTTLEHYDGVPGVELSVVENGSKLEARNSTDTDVVVRGYQDEPYAKIGPGGVFVNENSPAYYLNADRFGVTTVPAGADPRKPPRWRKLSDDQSFRWHDHRTHWMQTTLPPLVSQAPDEFHEISRWTVTLDYRGEALAGTGVLAWVPGPAPWGWFAGVLALLAVPALLLRRGLAFVVGAVVVSDVAHSVGVARLEQSNQVVSLLPQFAVWAIGGLAIWLLVRRHDAGPWAAAVVGVCVAVASGFPDLPVFWRSSAPTVLPLVVDRLSVAVGLGAGLGLVGALALHLVRGRHLRPAVPTPAAALAPDATPAATPDAAPDATPDATPDAAPDAAPDAAIAGAREPATARNEPGEEPREQGAVPREPATGPREPVGAPGEPVGAVSAAGAPGMRARGGRISRRQAVGLAVAGGAGAVAGAGLQAAASPEPPAATPEVGTVPLGSVGRQTVPFHGARQAGIATPTQRQAHARIAAFDLVPGADAAALRSLLQRWTTAAEALAAGRPASDRTDTMTADSGPASLTITVGFGPSLFGRPGFPATARPAALTPLPAFRGETLDPSRSDGDLGVLVAADDAVVVYSALRTLEQLAAGVATPRWQFAGFTRGRGVTTNEGATVRNLMGQLDGTRNPKPDEATFGRQVFAADGWMTNGSYLVVRRIRMLLDDWEKLPVAVQEHVIGRKKDSGAPLSGGVETTAANFGKRGADGQPLIPADSHMRLATAAFNSGAAMLRRGYSYADPLPGGGVEAGLIFLAWQADPRTGFVPVQQNLVAGNDRLSRFIRHETSALFAMPGGVANGEYFGQHLFEELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS81</accession>
    <name>A0A010ZS81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848863.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="30845" checksum="D39846EA929BF6EA" modified="2014-06-11" version="1">MTVPTVVTLDIGGTTIKGALVGADGQELKRLDRDTGASSGESEVVARVRAVARELADAGTVGVGLSVPGIVDTAAGVARHAVNLGFRDTPLAALVAEEVGVPVVLEQDCRAAAVAESEIGLGRDARDLMVVVLGTGVAAGLIVDGRPLAGADGSAGELGHLPVYPDGEHCACGQRGCLEVYASASGIARRYAAAGGTRAGATAADVASSLDSDVVAARVWREATEALGLALATATLLLDPALIVLAGGLTGAGDTLLRPVRSELQGALAWRQAPPVANSPLGGDAGRLGAAILAWRAAGYEDVVLRDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS82</accession>
    <name>A0A010ZS82_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850895.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2614"/>
    <dbReference type="HOGENOM" id="CLU_043026_0_0_11"/>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="6">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="34360" checksum="8E256146C6DD3543" modified="2014-06-11" version="1">MTVSYEMTHLQALEAEAVHIVREVAATFERPVLLFSGGKDSVVMLHLAVKAFWPAPLPFGVLHVDTGHNFDEVLAYRDESVRRLGVRLIVGNVQEDIDAGRVVEETGPGASRNRLQTTTLLRTIGEHRFDAVFGGARRDEEKARAKERVFSFRDKHGQWDPRGQRPELWNLYNGRHRPGEHIRVFPLSNWTELDIWRYIRDERIELPSLYYAHRRPVVARDGMLLAHTRHLALLPGEEPVETLVRFRTVGDATCTGCVESSAATPDEVVTEIAATRVTERGATRADDRISAAGMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS94</accession>
    <name>A0A010ZS94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862134.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="66" mass="7475" checksum="CCE9819377233DE8" modified="2014-06-11" version="1">METGVVKWFNNEKGFGFIAPDDGGPDVFAHYSAIQVQGYKELADGQLVQFDITQGQRDPRRRIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSG9</accession>
    <name>A0A010ZSG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848963.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335691_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="17958" checksum="9E9F9864FA536204" modified="2014-06-11" version="1">MVAGFGSAGTAVAAGFFSAGAAGTGFAVVTGFLPVGCSGTGFAAVAGDWSVGWSGTGFAVVTGDSAGAGTAGTQSGAASAGGTVAPVSGSAARDFGGATGAAAFGSVAGVSAGTSRGSSVEPVFGSVAGVSAGAARGGSVGAARGGSVEPVFGSVTGDSAGAAGAAVFGGTHVDSSVGNGLGAASAGAAAGVEDATTVGEGFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSZ2</accession>
    <name>A0A010ZSZ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692074_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4185" evidence="1">
        <location>
            <begin position="232"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="41393" checksum="318A28A1582B2ECB" modified="2014-06-11" version="1">MRAADRRVVAAAVAVALGASLIVVGVVLRRPERSPPSGNLPAVPAVRAVELGPIDQDGRVTARDNGQSTAYGDRSVWVFGDTVLRDPEGFLSNSAASTTDRRAADGVDLSGSVPTPVITHTPSESAFELAHGGDCSPAADLYCGAKFAFWPGPVIADPRRGRVLIFYVKLCRDGGEGTPCSGTYGRPLGTGIAALDMRTRRVTRLDASRSNPVLSVEGPDPTMFFPPSDAYNTAALTIGGDAYVYGACSERCHLARVPLDRIGDRSRWRFYSGREADGQERWSAETGAAVDTVEAGAAGNTVFPVRGLNGWLNVYLPYGDNVMRAQVGASPSGPWSPDFPLFTTRGADVNYAGFGHPEYAERDDLVQYVTYFQADTGDLRLVKLTLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTW1</accession>
    <name>A0A010ZTW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3238"/>
    <dbReference type="HOGENOM" id="CLU_587780_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="470" mass="52301" checksum="CC1E7BA59F223144" modified="2014-06-11" version="1">MGAEIPDPAKGVEMGSARRPILFVSYPEAGLINPLFVLAEELSRRGVDDLWFATDDIRADDVAALKVETPVEFASLGDVVPELSAQTWDDETYRKVTQGSRFGAHRAVVEKTFVPRLRVEKYRRLEEIVRRVRPALIVVESLCQFGREVAITHGIPFVVSTPFLPSTLLAPHIPFVKGHASRGFPVPHSGLPFVMTPKQRAVNLLFKFRNAAMGVSPAIRARVAEDAAVRKELGIADGTSDIIARAEMVLCYSIPELDYPLRIPEKMKMVGTVVPPLPQTSGDDDLSAWLDAHPSIVYLAFGTITRFTPDEVHAMVEVAHRLDGRHHLLWRLPPEQREWLPEELPPNLRVESWLPSQLDVLAHPNVRLFFTHAGSNGFHEGVYFGKPQVARPLWVDCYDEAIRGQDLGISLTLDHPDRVDPDDVVDKLTRVLDDLGFRDRAQRLGARLHAAGGRATAADLLQALPQLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTX1</accession>
    <name>A0A010ZTX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="32320" checksum="0AB1C67BA1CABAD0" modified="2014-06-11" version="1">MSGTTLPMRVWTGEVVRTEDLTPALRRVVIGGRGLAGYATTGVGDEYVRLIFPLGGEREPILPTVTDGHLDYGSIDLDTMRTYTVRAFDPVTTEVSIDFVVHDGGVAAEWARKAAPGDLVGINTPDGMYDPPAGLAWQLLVADFAALPAAARLLENTPSGVRTRAVLEVPGPEHHIPLDVRPGTEITWLHGGNGHGASRLEQCVRSMPRPDGTGYVWVAGETREMRNVRKYLRRELGLPAGAYKAVGYWTDGAETWRDRYDALDDATKASLEAIWAADADLADIEIQYDEKLARLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU11</accession>
    <name>A0A010ZU11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1747"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="23528" checksum="3CA55B99991C37BE" modified="2014-06-11" version="1">MTVSVLIVDDDALVRAGLEMMLGQFDDLTVVGAVGDGADVLPAVNRLHPDVVLMDIRMPLIDGLTATEQLRARRDPPEVIVLTTFDTDRHIRRAMRAGASGFLLKHTPPEQIARSIRQVAAGEPILSPAVVRRVMAFAAEPERDPRRDEARRLLGRLTDGERAVAALVGLGRTNSEIGRELLMSTATVKAYMTRILTKLDLTNRVQVALVVHDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUA2</accession>
    <name>A0A010ZUA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 31 glycosyl hydrolase, alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849829.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1819"/>
    <dbReference type="HOGENOM" id="CLU_000631_7_3_11"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="655" mass="73514" checksum="11D69D7810052821" modified="2014-06-11" version="1">MDALEVRFQHEVLRIEPWGTDSVRVRSAREQIPASDVGALQDRPESGPVTVEDGKLVNGELTVLVELPEDDGYPFPLVRFVRTSTGEELLAEEREHFWWPGARVHYGNRSGAGELHQQFKAYPGERLYGMGQRTHGRLDHKGLALDLVQRNAEVSIPFVLSNRGYGFLWNNPAVGRVEFADNVTRWTATQARAIDYWITVGSPASILSRYADATGHAPKLPSWASGFWQCKLRYRNQEELLEVAREHKRRGLPLEVIVSDFFHWTAMGDYKFDPEEYPDPAAMMSELDELGVRLMVSIWPTISPLSENYPKLRDEGMLIGTDQGAEFHATIRDKGMPVPMPITFHDPTNPATREFLWSVAKKNYFDLGVRVWWLDACEPELNPGHPANLSLHAGPGAEVVNVYPRDTARMFYDGMAATDDPETVLLCRSAWAGSQKYAAAVWSGDIPATWDALRRQVRAGLSIAIAGIPWWTTDIGGFHGGDASDEAYRELMVRWFQYGAFCPLFRLHGNREPRMSTGWDMTGGPNEVWEFGDTAFPIIKDVMFMRERLRPYLHAQLDRASSEGLPAMRPLFVDFPDDARAWEVDDQLMFGPDVLVAPVLEAGARSRPVYLPAGARWTHAFSGEVFEGGTTIEADAPLEQIPVYLRDGADVPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUM1</accession>
    <name>A0A010ZUM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169118_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458415" evidence="1">
        <location>
            <begin position="36"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="26027" checksum="DB5B894637E5068F" modified="2014-06-11" version="1">MTSRTIRSRWAAAAAIAVVAAATGGAAISAPAAAAGTPTTAASAPPPGQRSLTIASSPEKFDWRKATLDVPWTTPRLPDGSRCPGGRLSFQRQTPAESDFGKVQLGRHSIYVRKVDTADVTRDGQPDQLIQFNCLTTKTTVGYTWYYVYSFKKVYGYHGKINYRPYVRDYVTSTEFKANAKWVVQGIDARSGAVDVRQSVKGARSNPIRRVFRWSDRRGLIASRPLPVHPEADRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV07</accession>
    <name>A0A010ZV07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850184.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2103"/>
    <dbReference type="HOGENOM" id="CLU_417807_0_0_11"/>
    <dbReference type="OrthoDB" id="956283at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459244" evidence="2">
        <location>
            <begin position="29"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="659" mass="68964" checksum="594EFFE3353E8DFA" modified="2014-06-11" version="1">MRHRPILTAVGAAGAVAGLLLFGGPTAAAPDPAPHPAAPDATRQLGLPDVAKKKAVAAGAVNPYLGLVPEPNKVDWAYWRKKMAADGQQRTVSRKVGTGDPRGLATRDVEPVFVDEQEPSRTLGGNDKIGTAETLSRFGSADGRTPSARIVGTLAEGPAAVQFDPPKEDNGSIRLASNVVLPGSQTRRTTTGRIGDGPHGSEGDKKGDFDFYRIATAKAGQRLLVDLDTPTSNDATQPKLDSVVVLWNKAGKAIALNDDDGETLDSRLAVNIPSDGEYYVSVGAYDSPVPEDPFDSGSGKGVGAEGAYSVTFGLDADDVDFYQVDLRAGDVLGASVSGSARELSVRDPEDHLRITSRQDQSGIYPPTSPLPGGGNSVLAHVADATGPHTIAVSSGAGRYDLTLQVYRPGPEKRGASTVQTIFLDFDGAQVNTKIWGGTGVRTLSPFRAFLGRWGLKSDQENAAIDATIRSVRENLEHDFGGRAAIRILNSRDNHDPWGEPNVSRVVVGGSSDEAGLSTVGISQSVDPGNFDTEESALVLLDDISNPGGARNTSNPSLLAYLNGSSNRVAFVGQAIGNAVSHEIGHFLGSWHTAAFDDTADLMDQGGNFAMLWGVGADQIGGTADDDDVDFGRDVFNPGEGFAGSQSTNANTEWGLSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV65</accession>
    <name>A0A010ZV65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850280.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2165"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_11"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="113"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="33290" checksum="C0901024B7474471" modified="2014-06-11" version="1">MRIVVLDDHQDVARTFGPFDRLAAEIVVRHEHVSDVEELTAVLRGANVVVAMRERTPFGAAEFARLPDLKLLVTTGMVNASIDLAAAAAHGVTVCGTESAPGPAKATAELTWALILAVLRNVPAEDRALRSGQWQTTVGTGLAGATLGLLGLGRLGSQVAKVGRAFGMNLIAWSENLTAARAAEVGALAVTKDQLLTRSDVMSVHLRLSDRTAGLIGAAELARMKPTAVLVNTSRGPIVDEGALVAALHAGALGGAGLDVYDTEPLPAHHPLLTAPRTVLLPHLGYVTRETYALWYPQIVENIEAWSAGAPIRVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVD2</accession>
    <name>A0A010ZVD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852586.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3821"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_11"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="33298" checksum="BDA4BEE55E150DB4" modified="2014-06-11" version="1">MTITTRFDAASTADDVVSGVDLTGRRAVVTGATSGLGVETARSLARTGAAITLAVRDTAAGAGVARDITATTGNPHVDVRPLDLADRSSVARFVRGWTGPLHLLINNAGIFRSELHRTPEGWEQQFAVNHLGPFALTVGLHRALAAGGQARVVMVSSTAHMNSPVVFDDLHFERRAYDPQLAYAQSKTATSLVAVEATRRWAADGIVANVVNPGGVATGLQRDFTPEQTDYLARAEAAGAFAYKTVPQGAATTLVAAVAPEFAGTGGHYLDDGREAHTVGDDANLFEHSHGVKRWALDPDTAARLWTVSADLIRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVE7</accession>
    <name>A0A010ZVE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850390.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2255"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_11"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="347" mass="37048" checksum="6F6F1B692FA9BD70" modified="2014-06-11" version="1">MRTVNAIAATSATDPLVRTTIERRDLGARDVLIEIRYAGICHSDIHTVRSEWGPVTYPLAVGHEIVGRIAEVGADVSRHAVGDRVGVGCMVNSCRECEPCRDGQEQYCLGGATMTYGGVDRDGSVTQGGYSTHVVVDEDFVLRVPESIPYEAAAPLLCAGITTYSPLRHWKAGPGSKVAVVGLGGLGHMAVKIAAALGAEVTVLSQTLNKKDDGLAFGAKHYYATSDRDTFKTLRNSFDLIINTVSASIPMGSYLRLLRLDGTFVSVGAPPDPLEVPAFALIGARRSFAGSNIGGIAETQEMLDFCAEQGIAPEVEVIGADAVNEAYERVLSSDVRYRFVIDVDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVN9</accession>
    <name>A0A010ZVN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850515.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2750992_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="70" mass="7440" checksum="75890F49238AD634" modified="2014-06-11" version="1">MSPSRCATGSSATNAACSTRFADAGFARYARRAAARQLRARPAPAGTGALEPVETAPLDRWLERIDRPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW18</accession>
    <name>A0A010ZW18_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_4_2_11"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="24242" checksum="F77ABC391B7D248C" modified="2014-06-11" version="1">MSSPAVRAVALGVILLMCVGFLLTSGVPEPAELRAYVAQAGPWMPFGVAGIAVVTSVLMVPRGVPALLAGLLLPAPVAVVAALCGIALGASVSFLLGRWLGRPFLSGRTAAAGPDARLARLQSWLDRDGTRAVVYARILPVFPFGLLNYLFGATTVRMLPFVLGTAAAIVPSTTAYVLVGASAEHPGSPAFFLSVGLVALVGALGLAHAWWSRRRGRRIAPPEEPATPALSASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW71</accession>
    <name>A0A010ZW71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sarcosine oxidase, beta subunit family, heterotetrameric form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852980.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4091"/>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_11"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006278">
        <property type="entry name" value="SoxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01373">
        <property type="entry name" value="soxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="43886" checksum="925A7169BC29F4D8" modified="2014-06-11" version="1">MPPPPNHPRSLWRNPEPKRAYDVVIVGGGGHGLATAHYLAENHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDESSAIYEHALKLWEGLEEDLGYEILFSQRGVLNLAHTLQDVRDSVRRVEANKLNGIDAEWLDPDEVRKVCPIVNTSSDIRYPVLGATYQPRAGIAKHDYVAWGFARRADEAGVDLIQDCEVHGFATTGDRVTTVRTTRGDIAAGKVLLCAAGHTSTLTDRLGFRVPVQSHPLQALVSELLEPVHPTIVMSNAVHVYVSQAHKGELVMGAGVDSYNGYGQRGAFHIVERQMAAAVELFPVFARAHLLRSWAGIVDVSPDASPIAGRTPYENLYLNCGWGTGGFKATPGIGWCLADTVANDEPHPYVAPFTLDRFVSGALVDEHGAAAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY14</accession>
    <name>A0A010ZY14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851689.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3203"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="24003" checksum="E70C9B5A4D75A6C7" modified="2014-06-11" version="1">MTRPTVVLVHGAFADSSGWGGTITHLLDAGYPVVAASNPLRSVAADAAQVRALVDSIDGPVVLVGHSYGGVVVSTASAGATNVRALVYVAAFAPAEGESAASLAALYPGSTLGEALRPVPLPDGGQDLYLDRGLFHQQFCADVPEDLSTLMAATQRPITAAALNEAVAGPQGWQSIPSYFLIAGADRNIPAQAQHFVAERAKGVVREIADGSHATFIAHPDVVAALIDQAASESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ23</accession>
    <name>A0A010ZZ23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852268.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3618"/>
    <dbReference type="HOGENOM" id="CLU_049301_9_5_11"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15229" checksum="F228C7AE905733D6" modified="2014-06-11" version="1">MNENEGRIVVGIDGSDPSKQALAWAVRQARLTGAQIDAVIAWHPVVVFGYMPPPGDFDVEGAARSALADVIDKTAADAGDVPIHPRVIEGAATRVLVDAARGAQLLVVGNRGHAGFTEALLGSIGQYCVHHAACPVVVVRGSDGEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ62</accession>
    <name>A0A010ZZ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852356.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3663"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_2_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="32751" checksum="4DCAF2C2AD481FAA" modified="2014-06-11" version="1">MTTLSTTPRRSVPYFVPAVLAVMLMLVITASASPQFLDGGWKLVFVYASPLILLGMAQAPVVLSGGGGMDLSVGPAAGLISVVLAAVLIPNQLSVWWLIVLAALVLGAAAGAINGALVAFVRIPPIIATLATYLVFAGLATQILAAPTGFLPGWMRWFTGTDGPLPNVAYVVLGVGAVWWGLTRTAYWRNLRAVGSSDRAAYASGVPVTAVRFLAYLVTGVFTGVAGLVLTAVLGGADSTVGPTYTLQAIAAVALGGVSLAGGRGGLLGAAAGAVLLFLIQNYLTLTQASSFVLQMVYGVVLVVAIVANGLWDRRRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABA3</accession>
    <name>A0A011ABA3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859993.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.283"/>
    <dbReference type="HOGENOM" id="CLU_151185_2_0_11"/>
    <dbReference type="OrthoDB" id="1999616at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11540" checksum="BFEA4DFEF28BC57B" modified="2014-06-11" version="1">MRANTATMVKSEKDVDDVADRLTFTLTTLMSELTPLQSAWLGQGGASFQQVRDRFDQDMGRLNKSLRSMAEAVGTSGRNYSVSDQEMKSEMDAAGATAGSITAALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABR6</accession>
    <name>A0A011ABR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2786891_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="76" mass="8654" checksum="7EC50ADB433FF4FB" modified="2014-06-11" version="1">MGMVWHRPLTPEDVATAYRLLDQHEPLERYRDDPMCGNAGHWQAAPNWPCSRVRWAAEVVASSERGEIPDDLRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABX3</accession>
    <name>A0A011ABX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.559"/>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="248"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="441" mass="46144" checksum="C0EAD6E4502FCA55" modified="2014-06-11" version="1">MSGAPDETAQTAENARESAGAAPPATAPPKELPRWRRVLVDTTPLRNVAYRRLFLGQSVAFIGYQLTAVAVPVQMYAITDSSFWVGMLGVAGLVPLILFGLWGGAVADAVDRRTLLLISSVVLWVATGALVVQSLFGVDSPWLLLALTALQSAAFAISGPTRSAIIPRLVPIEQVPSANTLNFTASNFGTVVGPLLAGLILAQWSYAVAYGVDAVLFTFALYAAARLPHLEPIGERVSPGLRAVGQGLAFIALKPVLLMSFAVDIIAMVFAMPRALFPQVANDWYGGGEAVGWLFAAIAIGSVLAGLSSGWIGRVKRQGLALTVAVMGWGLAVAAAGLARSLWLAVALLAVAGAADLVSAVYRQTILQVYAPDEMRGRMQGVFTVVVAGGPRLGDLRAGVTESWFGPTVSWVGGGLVCVVLVALVALAVPKFLRYDGNPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD87</accession>
    <name>A0A011AD87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage phi-C31 gp36 major capsid-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569783.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723027_0_0_11"/>
    <dbReference type="OrthoDB" id="755947at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40765" checksum="7E1766277501BEBD" modified="2014-06-11" version="1">MSQSLADALEHALMRDSHRIRSLEVRARAGVHIEERETRDLIARSARIEETRGLLYRRGLQEQREQLNEFFRGRRGKVLDNVMDPWAPDHEARALSKLTGGAGANTVGQGFVDQVVFHLSEVSGIARGARTLMTAKGDALPMPTTTAHSSGALVAEGATIPTSEPTFGQRSLGAYKFGAKVDLSQELEEDTSIDMVDYLGLELGRALGVTLGGYLATGTGSAQPAGLVPNATVAVTGGTGVSGAPTADNVLALFYSLIAPCRELSTTGWVMRDTTLLQVRQLKGSDGQYVFPVQTRADGVELLLGKPVWTDPFVPAIGLGNRSIIFGDLYRFVVRLVAGLRLERATGPGFNNGTIQYRALLRADSVLADTSGAVRAFVGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADM4</accession>
    <name>A0A011ADM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2989053_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="57" mass="5921" checksum="E59605C92958606F" modified="2014-06-11" version="1">MDAAGVFPVLPALGSSTRSAETIVGRVLVEDEILASWLDVLIADGLVPPRASLGNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEG8</accession>
    <name>A0A011AEG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849305.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1478"/>
    <dbReference type="HOGENOM" id="CLU_110679_0_0_11"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="19941" checksum="2E3ABD891D9C7B3E" modified="2014-06-11" version="1">MTDPNAPGPYGSEQPYPASGPSYPTSSGGSPTSGGAYGTQGPYGAPYGQQPPYGTPYGQPQPGYGYPPKPVDDTKTWLMVAHFGGVAGVVVGGTVAGWVAPLIAYTSKGPTNPTVRAHSVEALNFHITWAIANVVALVVFFCGSAVTLGFGAIVLWVLPLATFVISVAFGIIAGVKASNNEFYPYPLSMKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEX7</accession>
    <name>A0A011AEX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849547.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062437_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458516" evidence="1">
        <location>
            <begin position="28"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="104"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="34886" checksum="F94875DB40FBB549" modified="2014-06-11" version="1">MKIRVAGVALVAAFSLVLSACGGTESADSSSASAPAGPFEYKDARGKDVKISNTPTTVVAQSTVAAALLDAGYQVKGAYGELTPGADGKLSYQAGSLDPTKIEVLGKTYGEFDTEKYALMNPELLIDYTFDQKGLWYVPQAQASRVEKLAPTVAVPGNYKTTDEAIETFVELAGKLGADTSSPALSKAKSDYQAALAEVASVAKSSGLKVAIMSPGKDSLYVVNPAMLPEATTLKGQGLDVIDPTKATKDVFAQQSWEEATGYRDVDVILVDARNYDAAKADLAKIATWANLPAVKAGQVYPWYASAPYSYTSYAKIYQELATDLGAAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFY9</accession>
    <name>A0A011AFY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850070.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2001"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_23_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="401"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="650" mass="68604" checksum="52F4882D1054B21A" modified="2014-06-11" version="1">MTSPASTLRAAVGAVVALLLLLGGARLVVGHYVVSRNDERVHRATAAAAANDDLLLSLTEAQTGLRGYQLTGDPSLLDSYRRGLAGYATARSAVREAADRDPLRALVAAEIDEADAWVATSAPLGDAVGIADVSVVRRGEQQFDRLRSANARAATGFDADLTAARAHARSVDLIGDLGTALLAVLAAGLVLGLGRRVHRATGPFEEIRTVLARIRAGDRSARARPAGPPSAREAVEALNELAEDHQRLHSSESGRAEARQRAHDLGATVRASLDPEAILDEAVAGLGAVLEADHVYLRLADGTDRLWSRPGLDAPPIESLRADEPMIGAALTTVFSIDAESTGALVLARSRPWSDDDRVLLDAVAADTGRGLHVAQVYDHQRELAERFQDLDRQKTDFISTVSHELRTPLTSILGYLEILLSGDQGELTDPQERSLRVVERNAERLRELVGDLLTLSRIGSGNLEMTATRVEVTSLLDGVREVFGPVAAGAGVTLETDRGDGLAVVGDDRQLERVLHNVVGNAVKFTPAGGSVRVRVRGDEARVSFEVADTGMGIPAADQDRLFQPFQRASNAVASAVQGTGLGLAIARSIVERHGGEVTLRSAVGQGTTVTIALPRALGATTGSDTAVDPREAAIRAAKARALSRASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG14</accession>
    <name>A0A011AG14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850101.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2026"/>
    <dbReference type="HOGENOM" id="CLU_099018_5_0_11"/>
    <dbReference type="OrthoDB" id="2013803at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16673" checksum="DDED368472BE61C6" modified="2014-06-11" version="1">MAKDDKDEKDEKKKGGKKKLLIIIIVAAVVVLGGGGVGAYFAFFAHSGEENAHPEPTPSAVVVAEAITVNLADGHYLKIAIALQTTTNAVEAVDTSKALDIVISQFSNLEVAELSTNKQREAEKAELTEKVVKAYTEEKLEYVMAVYFTEFVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG79</accession>
    <name>A0A011AG79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655094_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="419" mass="43870" checksum="49D16EDF94CB643D" modified="2014-06-11" version="1">MWSASAAVGDAELRGVPEGYAPERDGTMELPRAMPGPSSGVYTVGRLGGAHRKSDKPGRQVDPTAGRSSRSGRSGRAERDPQDTGEWTSIWPDEQPTVSRAMPQPRPQQPRPQDPRPQEPRPQPSSGYDRGPAGYDRGPSAYDAGPAGYDRGPAPRPAPTSPAGRPAPPSRPVSSSRPVSSSRPTSGSRTGQRRAGGERRAKAGSRRRPSRPMRYTGARRKFSSWAPLAGGVLMLVLVLGATMLAERDRYTGNSSSALGSSSAPASQPAAGARSDQKKDDATAQAAEAVAAAINKDLDNLGCGRVEVDQTLVAYAGDHVDDMLTRNYFNTTTPDGDSSIQRVKSVGYDGTKVVESVVAGAGNPAEAARAAFPAPDTAANLPATVKVVSGGKLSCGWTKVGAQARMNTKSVAYWSIVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGT2</accession>
    <name>A0A011AGT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850423.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2274"/>
    <dbReference type="HOGENOM" id="CLU_093735_0_0_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="23417" checksum="D3701780E59BA471" modified="2014-06-11" version="1">MAAARTARKVPADKYDERRTQLAESALLTLGELGYARSSLREIANNSEFSHGVVHYYFADKLELIIYCVRYYKARCVTRYDAVVAESSTPEQLIDAFAAKLVETIVDEAPMHRLWYDLRTQSMFEEGLREAVLMIDQTLEEMIWRVVARYSALSGREVLTGPDAVYGLLDGVFQRALLGHLTDRPGALDDLRDQVRSLLPLLLVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHF4</accession>
    <name>A0A011AHF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2526"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="40012" checksum="6F39DF5D96F72D38" modified="2014-06-11" version="1">MDVLSGRTTNRALRRQNRATLLSALFLDGPLSRQDLTARYGLSQAAVSNVIADLMDDGLVVEAGALESDGGRPRILLRVSPDYASVIGVDVGETRVRVELFDLAMTPLAKADYPLEDLDPRSVVRHVRHGIESVAGGNVLGVGVGVSGLVEQGDQAVVHAQTLGWDAVPLERMLREGTDLPLHLDNGAKTWAQAEHWFGAGRGARHAAFALVGSGVGAAIVADGQSYRGASSSAGEWGHTTLVYGGRACRCGARGCLEAYVGAESIIARALEAGVRVEGPDEETQVASVLADPAAAGVLAETAAYLGAGVANLINLFNPERVVIGGWAGIALGPLLPQVREAAAAQAMRRPFAQASIELCALGTDAVALGAATLPVARLLAAGGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIB2</accession>
    <name>A0A011AIB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851148.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2807"/>
    <dbReference type="HOGENOM" id="CLU_039483_4_0_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29368" checksum="C904AF34C7EE503A" modified="2014-06-11" version="1">MTATLAAPLPSTLRLGLSRGRLEIRQFFREKDAVIFTFTLPAFLLLMLGFIFDEPLNGFPGTTVSQIFAASMIAYGILSTAFLSIGTGIASDREDGTLKRLHGTPVTATAYLIGKVMLVMVTTAAEIALVLGVGVVVFDLELPTEAGRWVTFGWLFALSVIACTLFGIAVSALVRSAKSAAAVLNLPVLALQFVSGIFVDIASLPETMVKIASVFPVKWMGQGFRSVFLPDELAAQEVAGQWEHGRIALVLGAWCVAGLVLALATFRWNDRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIT2</accession>
    <name>A0A011AIT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851415.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183439_0_0_11"/>
    <dbReference type="OrthoDB" id="2103479at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="234" mass="24752" checksum="98F861AC09133BFB" modified="2014-06-11" version="1">MSTRWPILRYLLTAHLLFLLLSLGAFVAISGLILGGVALFGTVSVSALDVGVGQFFRWMALGYGGHLFYTFLPHCLVHGRTRGEFVRQVPVYQVVGAAVLALAIAVLYVGETLLYRAAGWTQGLRPGHLYESGTDFGAVFVSYWAALLVWTVVGSMIGAAWYRFPGVGVLLVPVAAAILFVNGLNLNIGEWGPLSGGLAGGPWGLVGIAAVSTAVAVAVTWSIARDVPVHVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ22</accession>
    <name>A0A011AJ22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570288.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3112"/>
    <dbReference type="HOGENOM" id="CLU_003916_0_0_11"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1789" mass="200011" checksum="692FBD401ED1AAF1" modified="2014-06-11" version="1">MSTFDAIGNRGEYFAAHYYAERLPLDLRKGIFGRWTDRETDELEQRPTTREQVRALRGEYFTDPVRGFFVEHARLAAESLPAPDGVEGRPVADQEWAKRLTAWHHTVLRHFGYPVDRPDQVTVHRAGREHTLRVAFAGDGILAVDCGWAVDADAALDAHGPDQLLGPVRISAGESYATGSALATWLFNSQIVWPNQTEPGSPPRFVLLLVGGVLVLADRHCWGEGRFLTANLDGALQRYDRRQNGELATIAALFSYEMLRTGANGEDPAIDALLKTSTENAVGVDGDLRQGLQRSVELIANEILDRLIEAGVEPAQVARPDKPLGRELRDEALRYLYRILFLLFAEARPELGILPSDDGSYEAGYSLARLRELVARDEELIEGNTARGFHLYESLNVLFCKVNKGHRAYGTEAGDYQPGDDEATRKAKKERRSEDRGLRFEPLRSALFEPTATRLIGCEVPDPRSDDIPAPRLDLRLRNGTLHRVLRLLTMKRPRGKERGGFISYRNLGINQLGAVYEGLMSYTGFLATEELYEVAKGGNPKDGSWMVPSSQIGQFTDDSVFVRYDQADERRGLRGWKRHPRGSFVYRLAGRERQVSASYYTPESLTKLTVELALKHRLDQDRDANGATVETRAAELLQYRICEPALGSGAFLNEAINQLASEYLRRRQNETGKTVPTADALTELQRVKAYIALHNSYGVDLNATAVELAEVSLWLNTMHPGMRAPWFGLHLRRGNSLIGARRAVYTGSDAAGRNWLASKNPLPPTELPFRAAVENTDADAIQPLPVGAIHQFLLPATGWGTVAGESEAKALAPEAAARLGRWRKGILKPPKTTGGQRSELARLQGTARRVEFLWDLVVERMRISEREIARRIDVWGANPDDHEYVFIQRPEHPVPKEKVYKDLFEKVGTPYWRLKTLMDAWCALWFWPVDQAALLDGDDPAYEQTPVTPAQLSELLGVGRGEQVALFSRDVEQMQLLEPVVEETKPDGKKKRKEKPKILRDARIAMKELANWIDFAEALVGTEDMPEDSLASGFKTLKDLDYYEKLIPGLTGMDEELQLQARFPWLDKVESIAEERGFFHWELHFALVFAERGGFDLQIGNPPWVRPDWDEPAVLAEFDPWFKLAEKADAKEKEARRADVIARQECREYVLAELTGTSASVAWLRSPHVYPLAAGTRPDLYRAFMCQTWAHTAVAGTVGLLHPDSHLAGVGMEHIRAEAYRRLRVHGDFVNAGNRFFPPPVGRSSHFGLHVYGTPGETSFDHLSWLFSVDALRHSYRQGVPDEGILPGIRFDGDWDTRPHPSRVIHVNAELLAVWQGLTGDESGPAEYVRLLSPVSIAENRGIESLAGFPVRLATLLPQISGGYNEATAKSKGLIRYEVSEPSDWKEVVLKGPQIGVATPLFKQPTQGSGEVLGLDLTTLPADALPATEYRNATDRARFEAAQDRWIDHPLLERLLADPEELSAARVVLSEAAGIALDAVPDGDLQLYLTEKARRRCTEFYRVAWRKMIAPDTERSLYVALLPPGPSHIDGIRSAVARDNRSTTLLGGFWSALPVDYFLRTTGIGDLHVASAIRLPAPIPDHPLARALLIRTSRLNCLTAAYADLWPELHDRAWRDESWANGWDGLPPLGDVKPEWDWNTPLRTDRARRAALVEIDALVAVWLGVDAAALEAMYRARFPIMADFDEVTWFDATGRRLAGNRYAYGHGQTKEHFEQLQAYLADQRRPPESRQNTPAPDGYTPPFYKADRVNEMKAAHAVFQARLDEAIAAGEWDPVTHSRPGVQNRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ77</accession>
    <name>A0A011AJ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851640.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3176"/>
    <dbReference type="HOGENOM" id="CLU_028458_3_3_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="31963" checksum="23A7AA42D2025154" modified="2014-06-11" version="1">MRWVTYGRHRRAGLVVGELVHGFDVPLIDVLGDLTAAAARTPAEIVPLAGTRLHAPITRPPSVRDFLSFEEHARNATAAFGRSVDPVWYRQPVFYFTNPAAIRGPEDDVPISPGSERFDYEIEVAAVVGRPGADLTPAEAEECIAGYTVLVDWSARDVQQEESRVGLGPAKGKDGATSLGPFLVTPDELADRRDGQGYALRMSAAVNGRPHGGGTWADIRWSFGQMLAYASRGTQLCPGDVVGSGTVGTGCLLELSSLHGPDTYPWLRPGDEVTVEIERLGTVRARITPAPAVLPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJD7</accession>
    <name>A0A011AJD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subfamily IIIC HAD-superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851725.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3230"/>
    <dbReference type="HOGENOM" id="CLU_018095_0_0_11"/>
    <dbReference type="OrthoDB" id="1310135at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="39319" checksum="34161257C547BB5F" modified="2014-06-11" version="1">MKTVKCVVWDLDNTLWNGTLLEGDDVQVTAEARHLLELLDSRGILQAVASKNDHDHAWAKLEQLGVADYFVAARIGWSVKSESVRQIAEELRFAESTIAFIDDQPAERAEVEYHRPDVRCYDAARIPELGALPDLTPPVVTADSRNRRGMYRAAARRDSAREEHTGPDADFVRSLDLVMRIEHATEEHLLRVEELTLRTSQMNATGVHYSLEALRALLDDPAHRVLVVSMADRFGPHGAVGVVLMEVGGPAWHLKLLATSCRVVAFGAGAVLLRWLDDQAARAGAHILADFRRTERNRMMEIAYRFSGFTDDDCACRAALGFAGDGLQRLHLVTAEQPPPDTMTLEAPEPAGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJI8</accession>
    <name>A0A011AJI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide cyclase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3283"/>
    <dbReference type="HOGENOM" id="CLU_079860_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="45"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="23494" checksum="6393F4192B469764" modified="2014-06-11" version="1">MRGAPDQRRECEPTFRVTEIGSVPSARSAREGGSMELTATTTIRKPVPEVYAYWRDFENLPAFMAHLELVRTTGDRTSHWSAAAPFGTNVEWDAEITDETVAEIIVWRSTGDADVPNAGTVAFVLAPDGVSTEVHVALSYDIPGGTVGKAVAKYFGEEPHQQLDDDLRRLKQVLETGEVVRSDGSPWGKQARKEFPQRPAQPLSDAELEKGPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJK8</accession>
    <name>A0A011AJK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3409106_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="29" mass="2930" checksum="6388563905158E4C" modified="2014-06-11" version="1">MDADACLVIEVGDPQPGNLNLVGGEFAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJP8</accession>
    <name>A0A011AJP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3060691_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="53" mass="5776" checksum="D5DBEB080D34D275" modified="2014-06-11" version="1">MTTPQISLGMIAVANWVGGITGTEELALLIPTVAWVVVAIALALRLFRREQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK20</accession>
    <name>A0A011AK20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low-complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725061_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="40585" checksum="645085F65C2B96FD" modified="2014-06-11" version="1">MSLSHGRVDITHHRHVKSWEIDNRIYLGAGAAVLTLAGCAELGLYRWSSAWEWLRSARWEALLLFSGGTVLLLVAARHAGRPASEASATPVAATPSGHHDRWNSPSSLTAAVTAAAAIAALVFTGQQSRAARESVEATREQLRLTRLGQVRQRYSQAIDQLGAQGIDARTGGIYALERIMRESSTDQDIIVDILAAFVRNHRPLQSVIDSSIVPGDVQAALTVLGRRPTDYAIDGYPIPRWDPAGRTLNLSYTDLTGANLTRAKLAFADLTGSNLQGADLTLAQLTGAKLFKARLAKADLSGRVSSENDTANLGADLTRADLGDADLTGAAVGGARLSGALLDGVVGLECPAVRENRPCDWTTAELLVPRSAFSVVRGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALJ0</accession>
    <name>A0A011ALJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570655.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3943"/>
    <dbReference type="HOGENOM" id="CLU_033536_4_1_11"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33758" checksum="D06212893D507A4F" modified="2014-06-11" version="1">MPVDRSERRVAPQTAGPRDRRSTPRGAPRRAPLVSVVIPTLNEALNLPHVFAALPAGLHEVVLVDGGSTDDTVEVARGLRPDVVVVRQTRTGKGNALASGFAACTGDAIVMIDADGSTDPAEITRFVETLITGADFAKGSRFGPGGHSKDITPLRRVGNEGLNLVVNTLFKTRFTDLCYGYNAFWRRMVPVMDLPSTDLPARADGRKRWGDGFEIETLINIRVADSGVRVKEVSSIEHLRIHGTSNLNTFRDGARVLRTILSEFHRRTVRRRAAARPVPVLAVPGSGWHGQIDALLAAEKSAGRAAEESVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALK7</accession>
    <name>A0A011ALK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852745.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3970"/>
    <dbReference type="HOGENOM" id="CLU_381150_0_0_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="727" mass="74024" checksum="C8DAFF0D386E8E7F" modified="2014-06-11" version="1">MTGPPIARPPLAGRRRELGAVARLLDGATAGVGGHLVVTGPAGAGKTALADAAAALAAARGLPVTRTPTDRPGSPRLVVLDGADPLPDLVARLSADGAAVLITAAAPLGLPPEVHLGGLSEPDLAPLLPGLSPDAAHAVWLVSGGLPGPALDFAAGLDGTDLDAVVRAALATPSRAGFLELDAGLVRLLRDAAERPLPTALRARAVARLARALLGDASAAAHRRDLADRALVLARASDDPGTIAAVLDDRLHALWDPAAAGERLEVAAEIVAQACRAGDLPTELRGLFWRFTALVELADLDAAEAALVAYGRAAELSGDAEAAVVVLSRQAVLALVRGRFDLAEELTALVAERGRAAGLPDTDRLVATLAGNLALVRGTADPDVTGLRALARRIPGQYFEATAARVLVESGAEAEAALELTRSLPSVLAGGGPRWLGAVADLGVVAARVGERPAVEALYETLGPFSGRLVVWGGANTVTGPVDDVLGRLATRLGRTTEAAGHFDRAIALEERLGALPWLAATLAGRNAPGDAERAAAITGRLGSAPADPGWTLVRDGEDWVLRAGAETARLRNGRGVDFLRALLAAPGQEIAALDLAAGGAGLVVGAAEPILDADARRAYRRRLAELDAALAEADRAGDADAAAGADAERSALVAELRAATGLGGRPRTSAAEAERARVNTTRALRATVARIAAQAPLAGAHLGASLRTGRFLRYQPAPGGPTRWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALN6</accession>
    <name>A0A011ALN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">o-succinylbenzoate synthase</fullName>
            <shortName evidence="3">OSB synthase</shortName>
            <shortName evidence="3">OSBS</shortName>
            <ecNumber evidence="2 3">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menC</name>
        <name evidence="5" type="ORF">CryarDRAFT_4042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2 3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852833.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4015"/>
    <dbReference type="HOGENOM" id="CLU_030273_4_4_11"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01933">
        <property type="entry name" value="MenC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01928">
        <property type="entry name" value="menC_lowGC/arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="39357" checksum="5D14A4CFBBEEEAB2" modified="2014-06-11" version="1">MKLTGVQLRRISMPLVAPFRTSFGTQTTRELLLVGVIGDDVEGWGECVAMADPLYSPEYLDAAADVLRRFLVPAVRAAGSLAAPDVARLLAPFKGHQMAKAALEMAILDAELRAAGRSFARELGAVRDRVPCGVSVGIMDSIPQLLDAVGGYLDEGYVRIKLKIEPGWDVEPVRAVRERFGDDVLLQVDANTAYTVGDARHLARLDPFDLLLIEQPLDEDDILGHAELARQISTPVCLDESITSARAAAAAIRLDACRIVNIKPGRVGGYLEARRIHDVCVAHGVPVWCGGMLETGLGRAANVALAALPGFTLPGDTSGSGRYYAADVTEPFVLRDGHLDVPTGPGLGVVPIPDRLDEVTTSIEWLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALX2</accession>
    <name>A0A011ALX2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_4157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853043.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4130"/>
    <dbReference type="HOGENOM" id="CLU_025068_0_0_11"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="432" mass="47888" checksum="68C883187CD22D26" modified="2014-06-11" version="1">MTDERKDDFVLQYGDESLPLPVREASEGSGGLDIAPLLKQTGKVTLDTGFVNTASCTSAITYIDGDAGILRYRGYPIEQLAEKSSFLEVSHLLIHGELPTEAELSRFTEDVKEHTLIREEMRRFFDGFPRDAHPMAVLSSGVSALSTFYQDSLDPFDKDQVEISTVRLLAKLPTIAAHSYKNSIGHPTLYPDNSLSYVENFQRMTFGLPTTPYEVNPLHSRVLDMLLVLHADHEQNCSTSTVRLVGSSQANMFASVSAGVNALFGPLHGGANEAVLSMLSKIDAEGGDVGSFVSAVKDKSAGTRLMGFGHRVYRNYDPRATIVKKAAREVIDAMPNPDPMLDIALQLEEIALSDDYFVERKLYPNVDFYTGLIYRAMGFPPRMFTVLFALGRLPGWIAQWREMINDPATKIGRPRQVYTGATERDYVALSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALY9</accession>
    <name>A0A011ALY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Family 4 glycosyl hydrolase, alpha-galactosidase/6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570713.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_11"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="192"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="43486" checksum="7C1660F3A014CCD5" modified="2014-06-11" version="1">MSIVLIGAGSTVFTPGLLTDLAADPAFAGWTVHLVDLDAGAAETMARLGARIAAAAGADLRFEAHTDRRAALPGARFVVSTIAVGGAEGWHADLAVPEKHGVAQTVGDSVGPGGVLRALRHVPELVAIARDVADLAPGATIVNYSNPLTANVRGIHRATGVPVIGLCHGTRHVLAALAARLRVPAGEVHAVFAGLNHLCWLLDLRHGSTDLYPRLRELELEPFSADLMRLFGLYPAPGDRHVAEFFPWYLRGNESPPGRAETLRYIGEKTSLWERLHDQAEGRAPLDPTRDQEAERLVAILASIITGRESVELAVNLPNEGKIPNVPSNAVVEVPAVVSAAGVNGVAVGALPPAIAAVLTARAQQQELTVSAALAGDRALAIQALALDPLVPDPATATAILDDAVVAHAPRLDGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFJ6</accession>
    <name>A0A010YFJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.13"/>
    <dbReference type="HOGENOM" id="CLU_697781_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="274"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="37488" checksum="2161F623FBCC1902" modified="2014-06-11" version="1">MTDSENTDGPGAQNSSSSARASAAVGKATVGRATVGGSGTPSRETTTRSAGTGASSAKPAAAAPKQPPKPGATDSSTTKPATAAGAKPAVGAGAAATAKSAAPTKPAAAKATPAAATPAAGSASAAPSAAPTSGGASNGAGRPATKSQGTTYGKPVTPAPSAGAGTPPTSGAGNGAATRITPAAKPPASTPPAAAATAAMPSFDSGPAQASRPGAASVSPPAAHAVPGSVGAAAPVSGGAAVQQPGSAAPPRVQVGDAVRSARQTVSAAASRGPRRARLQLKKVDPWSVMKFSFAVSLVLFIASIVATSILYMVLGALGVWDSLNETISTVTAGQDGSQGVDLAITAKMVIGGSALLGAVNMVLFTALATLGAFIYNVCADLVGGVELTLAERNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGZ4</accession>
    <name>A0A010YGZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.573"/>
    <dbReference type="HOGENOM" id="CLU_004665_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1099" mass="117350" checksum="C053CF8844B22B14" modified="2014-06-11" version="1">MSVSGDGGGVRTVEIGLLGAVEVTVDGASVSVGGHRLRAAFARLALDAGRMVTVSTLVDAVWGDDPPAGSGNALQSLVSRLRRTLPAGVVESAPAGYRLAVAPESVDVHRFERLAAAGRRTLESGDPAGAAETLREALSLWRGPALADIGDAPFRAAVVTRLENARLAAIEDRIDADLALDRHPEVVAELEELTAEHPLRERLHAQLVLALNGASRQADALTAFDRIRRRLADELGVDPGAVLKGAYTTVLGSPGVPAKQSVRMPAAPRPVTTNGARTRGNLRPQLTTFVGRRTELAAVADLLAAERLVTLIGPGGAGKTRLAEESGARLTDRNTGGVWMVPLAPIGEGDEVPQAVLTGLGRRQVGLLDTKLSNEASAPQDVDAILVKALSAGPTLLVLDNCEHLLEPIAALAHSLLLDCPELRILATSREPLGVPGERLHPVPSLALPPPGRLTPAQAARYPAVQLLVDRAASVRPGFALTPENVDAIVEICRSLDGMPLALELAAPRLRSLSPEQLAARLGDRFRLLTAGSRTALPRHQTLHAVVAWSWELLTAQEQVLWRRLSQFPGGATVDAAERVCADDDLLRPGDVLETLASLVDKSLVELVAEAEPPRYRMLETVRAFGAEQLETAGETAATRDALLAYFVELVETAEPKLRSPEQRTWANTLTAEYENITAALRWAVDQGRGDPAVRLVAGLAWYWALRGAHAEADRWATAVLPLADQAPPVSAAIVTAFAGLTAASLRSTYEEAKREAERVTELIKPFATAPDAHPVLVLADSIIHFLGDRNDQVQEKLERVYRHPDPWVSALALFLDANLHENDGDLLVAEQLFESARSAFESIGDRWGRGAVLSSLASIKALRGDHRGAIEALEQARALIYDLNGFDDLPRVLLWLALEWARIGDFERARAYLDESTTHVARLGDDDNAVGFLGAARSTVLRLTGDLTGAAALLTTEIERYRAHPYGPPQIYALLLADYTYALVAVGEAEQAVDYVLEALSQAAEAHDSPVLGGSLDTAAAVALALGDPAGAAQLLGAAALVRGLPDLGNPDVVRTRELAAEALGPSTFEARYRDGETMPKDDVLDLARELLTQVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHF6</accession>
    <name>A0A010YHF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848476.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.736"/>
    <dbReference type="HOGENOM" id="CLU_016265_1_0_11"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36739" checksum="F5ABA521480FE76E" modified="2014-06-11" version="1">MTTTDVPSTGTDYGLLARRITAAGLLDRRPGYYAVRTGLLLALGLAAAAAYLSLGDSWAQLWVAAGVAVLSAQLGLLAHDIAHRQVFRTARASGIAGRIVGNLGIGMGYGWWSEKHTRHHANPNHSELDPDVAPDLLVWSEEQARDARGAARVVGRWQAFLFFPLLTFEGVNLHVASILALRRPTMRHRVLEAALLLAHFVGYVAALLLVLSPGRALAFAAVHHAVLGVYLGCTFAPNHKGMPEPAEEHRRDFLRRQVLTSRNVRGGPILDVALGGLNYQIEHHLFPSMPTANLPKAQPIVRAYCAEIGVPYGETGLIDSYAQALRHMHRVGAPLRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIL7</accession>
    <name>A0A010YIL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848886.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1143"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22171" checksum="EBD50F5EB898852E" modified="2014-06-11" version="1">MSVRVLVADDQAAVRTGLVLILSSAPDIEVVGEAADGQEAVELARSLRPDVVVMDVRMPKLDGIGATAALAADGVADVLVLTTFDLDEYVFGALRAGAAGFLLKDTEAADLIAAVRLVAAGEGMVAPRVTRRLIDAFARGAVARPAPPPELEKLTPREREVLDCLGRGQSNAEIAAALDMAEATTKTHVSRILAKLRLRSRTQAAVLAREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJN0</accession>
    <name>A0A010YJN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03943 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849332.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1492"/>
    <dbReference type="HOGENOM" id="CLU_079638_0_0_11"/>
    <dbReference type="OrthoDB" id="1936285at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="25005" checksum="27580B5C33233B08" modified="2014-06-11" version="1">MNREAQSIVLLLIGGALLRLTVFSDVYLRYVKPGLRWYLVAAGVVLVVAGAITLWRDLFGEESEHTGPKVAWLLLLPVLTIFLIGPPSLGSYSAEKQGAAAVQQPRSDLPPLPAGNPVELSVLDYVTRALWEDGASFRGRQVRLTGFVTVDGRGTAYLTRIVLSCCAADGRPLKVALAGVPPSTLERDVWITVVGGYDPTRHTDPVSDETVPTIAVRTLTRIDEPTEPYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKI0</accession>
    <name>A0A010YKI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849778.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1728331_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458809" evidence="2">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="14899" checksum="73BC8BC4A2B68AC3" modified="2014-06-11" version="1">MTHAPRPLRRARRAGARFALALCAAVLAAVGLGGAAAPAFGAAPGAANSGSSVGYGATPTPATARAVGHGAVSGAANRVRPNNPPENSKPVQAAVHRGQTDVLPVAITDTRLGLIEPTLLAGRTLTSAPSRAPPAPAGLPDTRAPPFSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKT0</accession>
    <name>A0A010YKT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine synthetase adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849916.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1883"/>
    <dbReference type="HOGENOM" id="CLU_006233_1_0_11"/>
    <dbReference type="OrthoDB" id="427701at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="3">
        <location>
            <begin position="165"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="4">
        <location>
            <begin position="380"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="3">
        <location>
            <begin position="628"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="4">
        <location>
            <begin position="888"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1032" mass="111706" checksum="F9E5AB0097FBCAB6" modified="2014-06-11" version="1">MTRPVPVGTSRLARLGFRDPSRAADLLGPDGLGWWSPEASAPAGPDGELLITELAAAADPDLAVLTLHRLNAAQKEPAALAASLREDVGFRHRLFGVLGASAALGDHLCAFPDEWRALVTGVWEPSPPSPELLREILLDAVGAPIDAGETWGSAGVKARGSGPDVVADLRLVYRRCLLRTVARDLSDAGPTGRSDVAMIATELADLAEATVRAALAVSAAALPDGAPAVRLGVIGMGKCGGRELNYLSDVDVVFVAEPGAPGEEFPGTENPGPALRAATSLASGMIRICQEVAWQVDAALRPEGKDGPLVRTLASHAAYYKQWARTWEFQALIKARPIAGDLDLGMAWMGEVTPLVWGTTTGKSRRDGAAGREGAVAEIRAMRQRVEQSLPAKEAAREIKLGPGGLRDIEFAVQLLQLVHGRGDATLRSGNTLDALRALIDGGYVGRLDGEAFDSSYRFLRTVEHRLQLQRLRRTHSLPTDHDELRWLAAMLGHRGGGDPVEAFHAEWARHSREVRRLHEKLFYRPLLEAVATVSNEDLRMLPESAQARLEALGFTDPSGALRHVQALTQGVSRRAHIQRALLPAMLGLFADAPDPDAGLLAYRQVSDRLGTTPWFLRLVRDEGLVAERLPTLLGTSVYVADLLTHDPEGLRLLAEDSELRPRSREVLHGALRAAATRHADAESSVVAARALRRRELLRTAFADLLGFDDVETVGRALTDVCDAVLVAALGVAERVVSEQRQGELPMRMAIIGMGRLGGSEMSYSSDADVMFVHEPLAGASEHDATVAARAVAEELRRLLSMPAPDPPVGIDANLRPEGRQGPLVRSLGSYAEYYRRWSKPWEWQALLRARPVAGDEDLGRRFVELIDPLRYPAEGLDTAAVTEIRRIKARVDVERLPRGADPATHTKLGRGGLADVEWTVQLLQLRSAAQVPGLRTTQTIAALGAARDASLISEVDHDALVAAWELAAQVRNGLMLVRGRPSDQLPRHGRELTGVARAVGWSSDDDTGEFLDDYLRTMRHGRQAVERVFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLY3</accession>
    <name>A0A010YLY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850456.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2293"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_11"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="47396" checksum="0ABD5452048185A6" modified="2014-06-11" version="1">MHTIPSVSRYKALVDSFAADIRNGELAPGTRLPTHRRLAADHGIAVVTATRVYAELEAIGLVSREQGRGTFVRDLALPAGLGVDQEVVAADAVDLNFNYPSLPGQTDLLRRALRDLATSGDLEALLRYQPHRGRPADRAAVAHHLRRRGLEVDPARVLIVSGAQHGLAVVGLGALKPGDLVAVDPLTYPGFKALAQSLSLELVPVAGLDALARLCARRPVRAVYTMPTLHNPLGTVMPLSSRAALADLAHRHDLLLIEDGSYAYLEPDPPAPLAALAPEHTVYVSGLSKSVATGLRVGFVVAPPVLGPALERAIRLTTWNTPALSTVIACRWLEDGTVDDLEVRKRADAAARQDVARSELAGLTLVGHPSSYFTWLPLPDDARADRLAVTLGRARISVTTAEPFSVASPAPRALRLALGSTDLESLRVSLRTVRRVVLEDAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN88</accession>
    <name>A0A010YN88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851067.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2735"/>
    <dbReference type="HOGENOM" id="CLU_020207_0_1_11"/>
    <dbReference type="OrthoDB" id="909676at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="21746" checksum="B9F1AE3C8C9002F7" modified="2014-06-11" version="1">MRFRRCGREAVLVEVADLDAALALYESVRAAGLPGVLDLVPAARTVLVRLDPGVTSPALVRDRIAGLTVDERRPVDRGAVEIPVRYDGDDLAGVAEHLGVTPDEVVARHTGSPWTAAFAGFAPGFAYLAGGDPRLDVPRLATPRTRIPAGAVALAGGFSAVYPADTPGGWQLIGRTSIRLWDVERDPPALLGPGVRVRFRPVNACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP79</accession>
    <name>A0A010YP79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926583_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="300" mass="33114" checksum="0E472F3D5FE92B17" modified="2014-06-11" version="1">MTRHDTRVRVERLSFFVESVEAVPEGWRLEGVPGYHPINWARPGDRFDQACRENGGDARDVALVVVELSESCTVVRGTGGDLLRSDDIISGERLTDDSDAGVGLLPWRDATESLAAILGLTPLDGRSGTGFDWSSVERELGAVLPPDYKRFVDGYGAGLVDGHITVCAPDAPHDWADLVPHNTWAQQCVRLDFAGPEKHAGDWPVGDPTYWTPDREYVPSWFEPGDELISWGHTGNGDLLFWHVEPGTAASDWPVVMKEEGPYWEQYPAGFSSTLASLLTGKIQSKYLSHWLGGPHSYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR71</accession>
    <name>A0A010YR71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570628.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3859"/>
    <dbReference type="HOGENOM" id="CLU_047202_0_0_11"/>
    <dbReference type="OrthoDB" id="1729032at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="198"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="36151" checksum="47F2894BE6819DB1" modified="2014-06-11" version="1">MRVSFRARQGGRRVDLVLGLLLVAGVLTGLGANTIGVDWPLDLIQLHAAGALAILLLAPWKSVVIRRGLRNPRQRRPVKALSLVLLVLVLVTIGSGLLHSTGRVEYVGPLTLMQIHVGAAIGAVAAVVAHFLGHWVRPRRTDADRRALLRLAVLGAGAAVATTAWDTWAATGRRFTGSVPKPALEVTSWINDGIQRVDAGQWRLRVGTTTFDLDEVLALPHERFTAVLDCTSGWYSRQVWDGVRLSALLRAADVEPGRSVEVRSVTGFARWFGAGTLDDVWLVTAVGGRPLSPGHGFPARIAAPGRRGFWWVKWVASVEPSSRPPWAQSVFPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVG0</accession>
    <name>A0A010YVG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301116_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="11145" checksum="D406E4B1B60BD6FE" modified="2014-06-11" version="1">MRPVSRGHHTNVWVTLRDIRERIRTADDVALLAHAPLDLYDLLRAVESVLALHDGGQLPSDPDGRFYCTGCPETPAGRVPWPCTTRTVLERALTGSEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW55</accession>
    <name>A0A010YW55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847974.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.392"/>
    <dbReference type="HOGENOM" id="CLU_183126_0_0_11"/>
    <dbReference type="OrthoDB" id="1831235at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="94" mass="10684" checksum="DC20FCF4DA1EE304" modified="2014-06-11" version="1">MSDLATLDALSTEELRERAFSRARRRGDVGFFWDLIQRLPSARETESNDESLGTIGSTIEEAVGLWRELTGHEYGDSEPLIRAAFIDYLLEHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWA4</accession>
    <name>A0A010YWA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848062.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.447"/>
    <dbReference type="HOGENOM" id="CLU_058050_3_1_11"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="30990" checksum="BD090373B361AE8F" modified="2014-06-11" version="1">MKPSAFEYHRPETLDEALGVLAELGADGKVLAGGQSLVPMLNMRLAAPHHLVDINRLTDLARIDVTTDAVTVGAIARHADVERDPEAERALPLLRQALTHVAHPTIRNRGTTVGSIVHADPAGEMPSVLALLGGSVQLASASGNRVVPVDDFFLAPLESATQPGELATSVTFPIPARHTGSAWLEVSRRHGDYAVCGLGALVTLDEDLRIASARGTYVSMGPTPVTVDFTELVVGRSYDAADWSAAGKYVSSVVEPEEDIHATAEYRRHLAGVLTGRALKAAAAHAVARTEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWM8</accession>
    <name>A0A010YWM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569657.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_0_0_11"/>
    <dbReference type="OrthoDB" id="1381894at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="86"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29142" checksum="191D3B7DF7EFE3BB" modified="2014-06-11" version="1">MIWAPYSPCAVGCLVGDEDRVPISTAVLRIVALLAAVLAVIPLAVVYPLLSAAERTAVAGGWCRSLLRALDVRMVVDAPAEAPAGALVVANHISWLDILAVGSVRPGRMVAKNDVRGWPLIGALATRGGTIFVDRHRLSTLPGTVADVRTALLSGSRVVAFPEGTTWCGAERGRFYPAVFQAAIDAGAPVEPVTVRYTAAGRPTTVPAFLGDDPLTASAWRIARARDVVVEVRCHPVLAPGGDRRTLAAAAAASVSVVRPRVDRLVGVHPGEVVDSHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXE4</accession>
    <name>A0A010YXE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147936_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17156" checksum="CE26A87FD360DB32" modified="2014-06-11" version="1">MAAVTLDNLGAWVLKGNADRVDLAGRFAREPRVSQWCVRPGYRMRLMRAPQPVVFWASGSQAGVWGVGNVADVPFLGEDGAWHVPLGLTIDPVSARVPRSSLRADSRLAGIEVFRQPQGPNPSFLTVEQFDVVRSYRDSQANPSGSLKSPSSAAIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXR2</accession>
    <name>A0A010YXR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097507_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="25421" checksum="C92E9611ED8D537F" modified="2014-06-11" version="1">MTPLEPVPRQPAAEEAAKELSKQIYQDEKPSLLQRVIDWILDTIDHLLDRAQASGPGGKIGLLIFVLLVVVVVAGLIWRFGLPGRNASVRRKTDPVTPTRSATEHETRADAYAAEGRWAEAVRERLRGVVAGLVARDLVDNRPGRTAHELAVEAGRVLPGASADLTEAAELFAEIWYGERTATAEHDQRMRGIATRVAAARPSEGELVGAGSWVAPGTSAPGTSAPGTSAPGTSAGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXS2</accession>
    <name>A0A010YXS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860178_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="6562" checksum="0D610E075E1A0772" modified="2014-06-11" version="1">MSRVTWVIPVIPVIPVIPVIPVIPVIPVIPVIPVILVALALLILGSASNAVGATGGTTVRKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY50</accession>
    <name>A0A010YY50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">CryarDRAFT_1198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569805.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1178"/>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_11"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26655" checksum="478D5A26F76E4E5D" modified="2014-06-11" version="1">MTDSSTVFTIGNRPDGRVADALRPVSFERGWSDHAEGSVLVEFGRTRVLCTASVVEGVPRWRKGSGLGWVTAEYAMLPRATHTRGDRESVKGRIGGRTHEISRLIGRSLRACLDLKALGENTITLDCDVLQADGGTRTAAITGAYVALADAVQWLASRHALAASPKKALKNSVAAVSVGIIDGEARLDLNYDEDVKAGVDMNVVCTGSGDFVEVQGTGEAITFGRDQLDALLDLAVAGCTELAALQQKALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYP3</accession>
    <name>A0A010YYP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1384"/>
    <dbReference type="HOGENOM" id="CLU_129852_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033437">
        <property type="entry name" value="DUF5130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17174">
        <property type="entry name" value="DUF5130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="15656" checksum="A8C8553248AE4DD2" modified="2014-06-11" version="1">MAPGDSPEIPASQLTSSQLTSIANGAAAAGPFSSRQLFRIDEALTAADRETGLTFSVYVGGLEEPLRGSAETMLDALPAPEDSVLLAVSPNQRALEIVTGQRAAKRIPDRACELAGMSMRAAFQGGDLAGGIVTGLRMLADRAGAARSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYQ9</accession>
    <name>A0A010YYQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849207.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1405"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="832"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="899" mass="95319" checksum="3B84A659A8B5F0AA" modified="2014-06-11" version="1">MWAPAQLSDPLVGRRVEKERLEALIAAARDGRGEALVVSGEAGIGKSALLDHAVEVAAGFEVVRASGSELEREMAFAALHQLCVPLLRRLPELSERHRTAVRVAFGLADGVPDLFHLGLAVLELMAAGDRPLLCLVDDAHWLDPASSRVLAFLGRRVAADRIALLFAARPAAGPDAPGSLTGLPALTVSPLNDQESAQLLAQKFPLPLDERVRDNLLSEARGNPLALLELPRAGGFLPPTSSPLPTRIQDTFRARLTNLNPDARSLLVLASADPTGDPTLLWPAARHLGLDVALAGAEATATGLAEFDARIRFCHPLARSAVYRAADPAELRTAHAALAEVTDPRRAPDRRAWHRAQASSGPDDEVAAELERCASRAQARGGVAAAAAFLRRSVTLTLDPARRSERTLTAAAALLDAGDADAAHALLATVDSTSLDGFQQARADVLRGRVAFTRPGERAGPMLVVSAARRLAPLDPESSRDCFVDALEMALAVGRARGVIDEVLAAARSSAPAAASPDLLDVVMSLAAEGPRGAVPVLDTVRAVHGETWWARRPALATMITAEVWDFATHTAIAAWLETTGRDTGSPTMLRLGLGQRASDAVLVGDVGQAIAAIAEEEAIADAIGDQPLVYPRLHLAALRGRRADALRLFRAATDADSGGDGGRVTNLHWATALLHNGLGNYPAALEAARASIEDRNLFHVGGVLVELVEAATRCDEPAVAAGALDTLTDHAMAGGTPTALGVAAYARGLVTGVEDDYREALARLAESPLVPYRGRAHLLYGEWLRRAGRRRDSSEQLRTAHRLLAASGAEGFARRAADELRAAGEKVSRRPGRSIDELTSQEVAVARLVAAGATSQEVAVQLFISKRTVDAHLRGIFRKLGLTSRRQLRDHRFGRPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ46</accession>
    <name>A0A010YZ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849414.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2896537_0_0_11"/>
    <dbReference type="OrthoDB" id="2052841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="6591" checksum="9AF3FDF0D4363BBB" modified="2014-06-11" version="1">MESFSFEPIEEPVVMSALQGPGTNALVTNPFAFEDVQEPVVMSALQGVGTNALVANPFAWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1N5</accession>
    <name>A0A010Z1N5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">CryarDRAFT_2439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850610.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2402"/>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_11"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="19958" checksum="DAFF4EA30DACB44E" modified="2014-06-11" version="1">MATTNDLKNGMTLNLDGQLWNVVEFQHVKPGKGGAFVRTTLKNVLTGKVVDKTFNAGVKVDTANVHKAAMSYLYKDGGDFVFMDSETYDQITVPAGTVGGNADYLLENAEVTVALHDATPLYVELPASVELVVAHTDPGLQGDRSTGGTKPAELETGATIQVPLFVNTGDKLKVDTRDGRYIGRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1Q3</accession>
    <name>A0A010Z1Q3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">CryarDRAFT_2459</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850643.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2422"/>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_11"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG81348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="23679" checksum="3EE8821F04E05B7D" modified="2014-06-11" version="1">MELFVAPSILSADFARLAEAAASVAGRPGTPGADWLHVDVMDNHFVPNLTLGLPVVKSIRAATEIPLDCHLMIEDPARWAPGYAEAGAHNVTFHAEATDDPAAVGRDLRKAGAKAGLALKPGTPLEPYLEILRDFDTLLVMTVEPGFGGQEFMAEVLPKVTEARRRVESGHLELRIEVDGGINADTIHAAAEAGADTFVAGSAVYNADDPAKAVAALRELAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1W3</accession>
    <name>A0A010Z1W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850724.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2493"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458922" evidence="1">
        <location>
            <begin position="28"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="46590" checksum="FD09BBB5D30187BE" modified="2014-06-11" version="1">MTFSRRSLLAGALGAGVLAATSGCSVASGLTTAGEPASTLQFWDLFGGGDGVRMQSMLDTYRNANPDITLKGTTFNWGNPYYTKLSLATVGNKPPDVAVAHLTRAKSMVEGGLLQELEPDVLARAGLTADKFNERAWNAGLVDGKAYAIPLDTHPFVMFYNTEICQKAGLLDADGVIKPLKGEAAFMDAMQKAKAASGGFAGAIALGSEVVTAWRAYQSLYAQLGGQMLADNGTKVVIDDAKALKTLTFLRNLTKSGLFPEKTDYQGSIADFSAGRTAFLFQGEWEITTFQTAKTPFSMAPFPHVFDEGPYAVQADSHTLVVPKSPKLTPDRLDRALQFIRSLLDQSKAWAEGGHVPSWLPFRDGPEFAALQPQAQYASAADSAAYDPEGWYSGSGSNFEIVTGSAVGATLAGLTEPQQALDDMRTNLENLAATASPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3U9</accession>
    <name>A0A010Z3U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3159"/>
    <dbReference type="HOGENOM" id="CLU_001265_59_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="412" mass="42985" checksum="7387615B891D5804" modified="2014-06-11" version="1">MAQRPALSSRREIGTASRRELGWALGVLCLTEIVSWGVLYYAFPVLAADITADTGWSTAAITAAFSAGLVVSALVGIPVGRVIHRHGPRWLMTGGSALAVTAVVLLAVAPSFPLFLAGWLLAGVAMSCVLYAPAFAAVTVWFGPRRVRALTAITLVAGFASTVFAPLTAVLDQHLCWRATYLVLAGVLAVLTVPTHWFGLRPAWPNTEQTENTTSTDDTRANSRPVRPLEFWVLAAAFTVNTVCLYAAVINLVPLLHGRGYSLTAAAWVLGIGGVGQVLGRLAYAPLVRRTGLTACTLAVFTTGAVTTGVFAVLPGPYAALIVVALIAGNARGLATLLSATAVSDRWGTARFARLNGVFNAPMMLATAVSPFIGAWLAGPLGGYPEAFAALAVLGLVAVMLAARRAPTEPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z588</accession>
    <name>A0A010Z588_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852367.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3669"/>
    <dbReference type="HOGENOM" id="CLU_041141_7_0_11"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="25923" checksum="7394BC380B43174A" modified="2014-06-11" version="1">MKRAERQYALVDLLRGARRPWSAARLADEFGVSSRTIERDIGSLQLAGVPIYADHGAAGGYSILREYSLPPLNLSATESLAVLAGLALLDSSPYQGAARRARAKIAAVMDEDHRAPVQELLGRMRVIDAVTPGDDGVPLGMLADVIAARRVVRLAYLGENADGGPDRATTTVRDVETLGLLRAGDAWLLTGWCRLREAIRGFRIERITRLEILAEVPPARDPALLEADLARWPTRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z601</accession>
    <name>A0A010Z601_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852670.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096188_2_0_11"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="19156" checksum="48331CABEB44A758" modified="2014-06-11" version="1">MPIEPRLIVTGHTPGGDAVFVTDQRPEPVRVQALPGADFYLLWGTPDGVATVGGPDPAPVLRPYFPGLGGSRALFLRWAPYADGPDDPDPDAVRREVADKLPGLLDPFEDDGDGMHTTDTVDYAICLEGELRLELDHGAVVTLTPGTCVVQLGTRHAWKNTSDRPALMCYVQIGAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6L8</accession>
    <name>A0A010Z6L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570709.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_2_11"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="20063" checksum="B38C741C12485D8E" modified="2014-06-11" version="1">MPDVAERAIHLMMAGTLDDLREVVHPGATNREAVAEPPACRGTGPEAFWATALWLRTGFSELAFTVDESVVERDLVVTYGRMSGRQTGDFVVWTAAGAVERAFAPTGRRFEVRHAHFQRVRDGLVVEHWAVRDDQSMAMQLGWLPPSPLYLARCARATRRARRAASASPSVPAAAAAPATTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6Q5</accession>
    <name>A0A010Z6Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570718.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4174"/>
    <dbReference type="HOGENOM" id="CLU_1298708_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20207" checksum="23AD3293E9F57A0F" modified="2014-06-11" version="1">MTGRRELHKQETRRALQEAAVRLFEQDGYDRTTVRDIAAAAGVTERTFFRYFATKEELVLGEVLDLLPVIREAVIERPAGETPYQAVRSALLALLDGLDRGIGILFASEEGATPSALAVIHQVEEALEDAFVARGVAAGLPASVLSKAATAAVHSTIETHTKLPEDQRTVDTARRLLGEAFALLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK48</accession>
    <name>A0A010ZK48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2750990_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="70" mass="7389" checksum="3E4630DE4868BDE7" modified="2014-06-11" version="1">MNMRLAPPPMRAPLQEPEDASPRSLPTWTKICVVLGAVLILVGFGGLGAAYAVNQKADPTTAGTSELIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKI2</accession>
    <name>A0A010ZKI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053651_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="2">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="409" mass="46443" checksum="E607FB90DF88F229" modified="2014-06-11" version="1">MENRVYGFRVRQARTLRGRPSGDLAKAVGWSPSKLSRVEGGGITDVNDADFEVLVKELRYPPQFFITDGLNLRGEDLLFRAPKSTPKRERQFLADFAAVTGDMLTWLDQHHRLPNVTIPAADLFSGRSGSMRDYRDIAELARRAREALRIDPGVPAPYLTYELERAGIAVVVRGRRPSDDPDAWDTDAAFSEKHLGYSIWVGDHRDRPAIVARALDSWERTRWTLAHELGHLVLHTDASAEFVEDEASLFASEFLAPLDVIRFELPKVLTLSGLIPIKLKWGISLYALLRHLLRADLVSEDRYKSMTDQLHVRKNPDTGRTWRRDEPGWDARDPERPALIRTWLERCIGTSDPNALQLMSERWPADFFEEVLATQRATARRVSPVPLKQPAPTSAPVVNLMDRRRRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKQ6</accession>
    <name>A0A010ZKQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with putative antiterminator output domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847749.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.247"/>
    <dbReference type="HOGENOM" id="CLU_074354_3_1_11"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="26291" checksum="BD72B6F4EB2C64D8" modified="2014-06-11" version="1">MTTVSAERLASVFVEFADTLTEQFDLLEFLHMLTGRTADLVGAAAVGLVLANKNGNLEFIAGSDEKAKLLELFQLQNREGPCQEAYRTGRPVVNVDLGEAASRWPRFAPQASALGFRSVHAFPLRLRSQTIGALNVFSDTSEGNFDRKDVPIVQALADVAAISLLQERAIHRGEVLTEQLQSALNTRVVIEQAKGAIAQIHQISVDDAFVRIRAYARNNNRRLTDVAHAVISDRSSVPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL41</accession>
    <name>A0A010ZL41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase/uncharacterized protein, coenzyme F420 biosynthesis associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.383"/>
    <dbReference type="HOGENOM" id="CLU_059556_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="38867" checksum="283B4C3072D5578B" modified="2014-06-11" version="1">MVDWDLAVSTAATLTGGGPRVSVTEAADVVLELRRLTDVAEQHVANYTGLSARVDHPPVQVVDRTDWVRTNVEGLQVVMDPVIEKLQAASPPKPTAFGPVGTAVKVVGQKATGVQVGTILGFFSSKVLGQYEVFSGAPGRLLLVAPNVVEIERKLGVDPTDFRLWVCLHEVTHRTQFTAVPWLRDHFLSEVSAFVDATDLDPEALADRVRNGISALADSVRNPDSKASVLDLVQTPAQRAVVDRLTALMTLVEGHAEFVMDGVGPDVVPTVESIRARFNQRRAARNPLDKLVRRLLGIEVKMRQYAEGRKFVAEVVERVGMGGFNLIWTSPETLPRPGEIADPDAWVARVVGPTVSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL53</accession>
    <name>A0A010ZL53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.398"/>
    <dbReference type="HOGENOM" id="CLU_733030_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="40988" checksum="2E9B3DCED2837A75" modified="2014-06-11" version="1">MSEPRRRPDPLTDPLGALESPDPLGGERPSRRERRASFGDPDEITPGRAVARREDPSRGAAREGRRSHSDELERPRRVPQQRRPEPADDEYDGRVLPRRPDRPRGADDSLRRSGEITDRPRSAPDPGERPRRSIDAPDRPRGVADTGDRMRRSGEITDRPRGSADTGDHLRRSGEITDRPRGVSDTGERARTAARASVPVAGRAVVGEPMRPDAAQRTSGRIVSVPERARSARSAPAVSRTPTGEPEAIRRINPFDLPAPRGYSHATIATGQLVFLAAQCGVDLDGRIVDGGLVSQFDRAVQNLLSALAAAGGSAEHLVSITVQVTSIDDYKASSRPIGHVWRARLGGLMPALSVSEVRRFWDAEAEIQIAAQAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMM4</accession>
    <name>A0A010ZMM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.965"/>
    <dbReference type="HOGENOM" id="CLU_071517_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27831" checksum="B89A6658C696E2F5" modified="2014-06-11" version="1">MTSDADTETIAARMTCDSDVELARLLATHAGVILLRLRKGKRVPASRLKADGDRRSHDFLTAALAKLRPGDAVLSEEGADDHARLEAGRVWIVDPLDGTREYSELDRDDWAIHVALWENGELTAGAVALPGLGPTLTSELSPRPRPAAAQPRILVSRSRPPAYAETVAEKLGAELVPMGSAGAKAMAVVRGQAEAYLHDGGQYEWDSAAPVVVARAAGLHTSRVDGSPLRYNNPNPYQPDLLICRPELADPILQAIATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMN3</accession>
    <name>A0A010ZMN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569755.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062020_0_0_11"/>
    <dbReference type="OrthoDB" id="1688876at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458366" evidence="3">
        <location>
            <begin position="25"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="373" mass="38589" checksum="E47B70AF9F276BA9" modified="2014-06-11" version="1">MGGRAALAIALLAIGLTGSSTSAADTGPRTTYGTPSTRCTVTDPRLDSISGMAATRGALYVVNDTAPVTVWQLDDRCRAVRQTILTLPAAHDPRATLRASGEKAVDLEDVGVAADGALWLADTGGNTSSRTVASLYRWVPGRTLDSARAGTPVTRDNPIPLVNAVRRYDLRYPDGPQDVEAVLPTLTGRLVLVSKARDGVAAVYETSVPLEPVSTLRRVGTLDLRPLLPGRALSVTGGAVSPDGVRFALRTPGVALEWDAPDGDAARALSNGVPRRVTLPKAPQGEAITYTDDGSELLTGGEQLPAAIGRVSITRTPGPASASGPVFPPAVLGGAGASALLIVGLGVLAWRRRPTAPGPEPVATEERELVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMP3</accession>
    <name>A0A010ZMP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.985"/>
    <dbReference type="HOGENOM" id="CLU_005126_10_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="15"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="663" mass="70130" checksum="E7C3D30627986723" modified="2014-06-11" version="1">MTAHDVGLLMLDLALILVLARIGGWLAQKVGQPPVVGEIIAGIALGPTIIGPHLSTLLVPIDVRIPLSALANVGLVLFMFIVGYELDMVLMRGKERIAVSVSVGSIILPCALGITLAYWLASRHDVAGDDVLPFVLFIGAAMSITAFPVLARILTDRGMHRTRLGGLALASAAVDDVIAWSLLAVVVTVAGASAEAQWHVLLTLPYVALMFFVVRPLLRRLLPLHTRAGRLTPTLLAVVLVGLLVSAYAAEWLGVHVIFGAFLFGAVMPREGGEALRQDIMEKLEQVSVLLLLPVFFFTSGIKVDLRNLGLDGLVELALILLVAIGGKFIGAYLGAKLQRVPNRQAFALATLMNTRGLTEIVILTVGLQLGILNQDLFSLMVVMAIVTTVMAGPLLTRFYPKRRIERDIAEAERLSLGEAPATRVFVVVDEPSTQGGEVEIAGALVGARRPAEVVLSRMLPYRAPALEVGTGLSGELLEMTRSLEELEELAARVRREDLPAPVLTRFSHDVEHELGLQVEASEPDVVVVRTGAHALADQVRGQLVTVGTLPETPSAVAVRWSADADGSAALRSAALLAAARRLPLVIDDGERAGRRATAAAADLARQGLIASADPAPADALVVVGGAGLVDGAHVAVRAARDTDVVEVSDWVADLPAPSPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZND0</accession>
    <name>A0A010ZND0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="7" type="ORF">CryarDRAFT_1255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1236"/>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="6">
        <location>
            <begin position="42"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="25238" checksum="DDD1C92C2220CA91" modified="2014-06-11" version="1">MLPDAHVTAHANGEPHDHDVFEQHAPLTGDLAPRTDKRAFRVGVGGPVGSGKTALVAALCRTLGPEMQLGVVTNDIYTTEDADFLRRSGVLAPERIAAVETGCCPHTAVRDDIAANLDAVEGLEETFAPLELVLVESGGDNLTMTFSRGLVDVQLFVLDVSGGDKVPRKGGPGVTGSDLLVINKTDLAPLVGADLGVMDRDAAAVRRGKPVVFQSLREDPSASTVAEWIRDARKAWLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNS9</accession>
    <name>A0A010ZNS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1379"/>
    <dbReference type="HOGENOM" id="CLU_037945_8_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="354" mass="38093" checksum="BB418D6E00F0B46E" modified="2014-06-11" version="1">MSLRLPAAVPSWFEEWPSFLNDNVAPSCALGKENEGSVCKWVWDSTESRWLANASEWLLAKPLAVVLIVVVAMLIRWAIYRTIRAITSVGNGDAEATTPDGKPKKKPRILRPFREKAESALLASGLMSERRAQRASTLGSVLRSVTSVIILVVAGSTILGLFDINLAPLVASAGIAGVALGFGAQSLVRDYLSGIFMILEDQYGVGDIVDLGEASGTVEGVGLRITTVRDVRGVVWYIRNGEILRVGNKSQGWAQVVIDVPIPFGTDLEKAHEVLTEAAARLTEEEEFKDDLLAPPEVLGVDQMTATGLMLRVTVRTTTAAQWRVARELRARISTDLAAAEITSGIAPIPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNX9</accession>
    <name>A0A010ZNX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569876.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1442"/>
    <dbReference type="HOGENOM" id="CLU_041268_2_0_11"/>
    <dbReference type="OrthoDB" id="1456447at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458030" evidence="2">
        <location>
            <begin position="38"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="39923" checksum="F743585BFF08E49D" modified="2014-06-11" version="1">MLQPVLAGVVTALVGFASSFAVVIAGLRAVGADPAEASSGLLALCVATGVTAVWLSVRYRTPMTIAWSTPGAALLVSTGAVDGGFPAAVGAFLVAALLVVAAGLFGPLARWIAAIPAPVASAMLAGVLLDLCLSPVRAVVETPLLALPVIVVWALLTRFARAWAVPAALVVAAAGVAITRFDEGLDATLRPTVALTAPTFELGAVVSIALPLFLVTMAAQNVPGMAVMASYGYRPPLRPALVTTGLGSAIAAPFGGHAINLAAISAALAAGPDAHPDPERRWIASVSAGVGMTLLGLGAGLATALVVLAPPVLIEAVAGLALLAALGAALTAALTSADSLSGGREAAVVTFVVTASGVTLAGVGAAFWGLLAGGAILLLFRRRSDRPVDVEVLGADEATDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPA2</accession>
    <name>A0A010ZPA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.70"/>
    <dbReference type="HOGENOM" id="CLU_299302_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="813"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1002" mass="104967" checksum="333295683D5EDF82" modified="2014-06-11" version="1">MTSRDAGPRLGDRYVLREVLGRGATGAVWAAHDIHLDRPVAVKVLIDAGDTLTTPERFQREARTTARLNHANIVAVYDVGRISEHDSIDAAPGTPFLVMELLTGGSWKDALSGPLPRPEKVAGALAGVARALAAAHAVGVTHRDIKPANVLLNADGEAKLADFGIAKSTESTGLTRPGDIVGTLAYTAPECLEGQAAGPAADVWSFGVMLYESLAGHRPFEQETLGALITAIQSGRYRSLAYDLPSLPHALSATVDRCLDPDPPHRPTAAELARVLSDAVATTTTTGSAPPTTITPVSGPPSFDPTTDAPAAWMPISSPPVSGPPSSGPPVSGPPVSGPPVSGPPVSGPPSGWRVAGPPPAPPTSGQRTGPTARVPSAPGSPVPIPGPYSGTRRATGGGVPPVNPPVPVAPHEEPRKRRRWVLPVAAGVVLVLLTGGAFAGRSLFHAVAGCSGELPLVVASSPEKAGVVTALAERYNADPDDVDGTCVRVQIVIAKSGEAVEALAKGWPTADYGVRPDVWTPASSVWVGLLGQKAGAIGAMAKAPSLARSPLVIAAPEATAKAMGWPAKSPSWQEIARYAGNDAEWKRVSKSETPFLFARTNPLVSTSGLHATLAAYLAAPGRTGDVEEDLQRSSVRLFLRTLERSTDRYGDTTLTFLETLRQQAEQSGTSSVSALAVEEQTVWAYNQGEPMSAGSSHLPAPAEKLVAMQPSDGTLVSDHPYVTVDSVIDAPWVTPAKRAAADDFQKFLLEDEQQAAFRAAGFRDSNDKLDPDVVAKSGGFIAERPATTFPSPQPAAVAALLNAWRDLNRPANVLIVLDTSGSMKEKVAGTKSTRLQLATQAAEASLDYFGTNDRVGLWEFSTKLDGPVDHRQLVPISSKNEGALKRALQSLTPKNDTGLYDTARDAVQLVRAQSDADGINAVVLLTDGDNQDPGSISPQALLAGLKAEPTVRVYPVAFGDELTRDGKNVLNQVAKTTGGRYYESNDPRRIESVLGDVMSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPU8</accession>
    <name>A0A010ZPU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074354_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26539" checksum="9FDA4F8BA8CEE063" modified="2014-06-11" version="1">MQDRPADAVENLTVSADIRTPAQAFAELGRIPITEPPLHDLLLKIAVLARRTIAAATEVSVTVVARNQATTVAHAGDRALALDQGQYRAGYGPCLDAARSGQVVVVTDMANEKRWPAYTPSAHEQGARSSLSIPLPVQHHTVGGLNLYATSLDAFDERAVELALAFAGYAAVALANAYRHTATAQLIEDMRAAMHSRAVIEQAKGILIARHGGTLEAALGQLTLTSQYADRTLCDTAEDLVLHAQLPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPY4</accession>
    <name>A0A010ZPY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847772.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.265"/>
    <dbReference type="HOGENOM" id="CLU_004435_3_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1169" mass="123403" checksum="369E5F9AA6B3C9D4" modified="2014-06-11" version="1">MTCPVCGTVAVPGARYCHHCGTRLPDVEPTGFATERRVVTVLFGDLTDFTAWSEDLDPERVGRLTDRVLAACAQAVTAFGGHVDKLTGDGIMAVFGAPVAHEDDPERAVRSALAMQRAVKRVIEDELGGGRRLGLRVGVNTGEVVAGVQAALSYTVIGDTVNTAARLSDAAGMGAVYAGARTQRATRDRAAWRRLPPLRLKGKRAPVEAYELLGLRDAAGIRPGLGDEAPFVGREVESGRLLGRFAEVAEENEPRVVVVTAEAGAGKTRLSAELARMVGDSFGARALSTRCPAFGETGRLAPLADLVRQACGVEPDEPDERIAERIRRVATDLPDPGLGPGGVEVLFDLVDVESDVDALTGVPGISTAAGRRARVPEVMAALLGGLAVTEPVLVVVDDVHNASPETLDALGGLVERLDGAVLVLLLGRPELVRTHGLLTRLPGAEPMPLPPLTGAAVSRLLRSYLGGPLDRADETRLLATAQGNPFYLAELVSLLVEQGRLTGGTSGWRLAPGGFRGRLLSSDLAAVLTARIDALPSYPRAVLRDAAVVGDRVPAGALEELQGSRRAPVTVTADLDRALGDLISRRMLRRTASGGYGFVTALMREAAYSGIGHADLAARHARIARWAESGPIRGLSDVERDEFVARHAERALRLADQMSLPPSHESRRVATIGVAALHGLAERTIAVGEPARALRLLDRAIALLPAGDRGPVSDDDLRLLRSRALLASGRTEEARELASSVALGEGSVAVAALLVKGEALRAAGETRAAVAAWSLALRKSRAAELPNCESEALRRLGMLDYLGGRLPLAERRFTAAYRVASACGDGPGTAWALQHLAWSATTRGDFGRADRVLEEARAVFARLDDPAGRSWVRGTTAFVRLLEGRLHEARRLAEKFVPYAERVADGWAVAALRIVDAFAAAELGDLTHATQQADLAHAAFLTGHDPWGASLALTVRGVIARGMDRLDDAVDLLSEALETGAQVGHPLTAGIALTVRGYCYLAAGELAAAEADAVRTLELIEPLDVDPSTRVGPLVLQAQARRLSGDRDGALQLLGEVVNDPSGPSLLFPRRQALAHYAGVLLEAGKSEESLEWARRASRVPAEDVRSRVVSRRALAVSLAATGALSEALTAADEAVALAYGTEQASERAASDTVRDRVALAHALERPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQG3</accession>
    <name>A0A010ZQG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850050.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="21803" checksum="9DD183556F096157" modified="2014-06-11" version="1">MTAAVGLYEPPDGWSDEELVQVPEGVHYEIEDGRLVVSPRPTFWHQEACRRLANVLEEQCPSQYWPVQEGEVRIYDGRVVAELRAPDILVVPRELTRRGAHRGWAHPHEVSLAAEVVSRHSYTPDRTTKVAVYAAWGIPLYLRLETEPEVICYAYRLGGNKTYEKPTEHRDLFTLEEPFQIQIDPALWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQQ8</accession>
    <name>A0A010ZQQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848282.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.575"/>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="202"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="733" mass="77211" checksum="3BF0026E4A156AF8" modified="2014-06-11" version="1">MAGLARWCYQHRIVVVVLWVVGLLGLGAASQSVGTAYNDSFALPGTESTKALDLLQGAFPDAAGESDTIVWHTDSGTVKDAAVQQRIEGMLGQVADRSDIASVASPYTEQGAGQISQDGKTAYATVTFKGSVEDEVDLDAVDSLISTAEKARTDGLDVELGGNAIQQATQAPPGSSEVYGLIAAAVILLIAFGSLLAMAIPLITAVLALAAGTTSIILLSHVMTIGTIAPTVAALIGLGVGIDYALFVVTRHRNGLMAGMSVEESTVRALNTSGRAVVFAGITVCIALLGMLVLNLNFLTGVGVAASIVVFFSVLTAITLLPSLLGFFGMRVLSRRERRRLAAEGPHEAHARGFWARWAGIVERRPRMLAAIAIALIAVLSIPTLSLRLGASDQGNDPADSTTRKAYDLLADGFGPGFNGPLQLVAELKSPSDTAALNELVGQVRKDPGVAAVVAVPTQPGAEVGIVQVIPTSSPQSEETSDLIKRLRDDVVPGVEDGTTMQVHVGGMTAIFDDFADVLTSKLPLFLGVIIALGFLLLTVAFRSLLVPLTAAVMNVLAAAASFGVIVAVFQWGWGAEALGIGAAGPVEAFLPVMMLAILFGLSMDYQVFLVSRMHEEWVHTGDNRRAVTVGQASTGRVITAAATIMIFVFGAFIFEGQRVIAEFGIGLSSAVFIDAFILRTLLVPALMHWFGRANWWIPKWLDRWLPHLTVEPADEPVAPPRPEEKREPVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQW6</accession>
    <name>A0A010ZQW6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">CryarDRAFT_2164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570011.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2130"/>
    <dbReference type="HOGENOM" id="CLU_041647_1_0_11"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="57"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40214" checksum="806640157CFAF307" modified="2014-06-11" version="1">MTSTVIRDIGMLVTQDPDLGTRTDAAIVFEHGRVAWVGPTNQAPAADTEIDAGSRAVVPGFVDSHNHLVFAGDRSAEFAARMAGTPYAAGGIRTTVTATRAASDDELRRRLATLVTQAHRQGSTTLEIKSGYGLSVHDETRSLRLAREVTEETTYLGAHVVAPDTDPADYLALVTGEMLEQCAPHAKWIDVFCERGAFDGDAARAVLAAGVRKGLVPRVHANQLGPGPGVRLAVEFDAASADHCTHLSDADVDALAGSDTVATLLPGVEFSTRSPYPDARRLLDANVTVAVATDCNPGSCFTSSIPFCVALAVREMRLTPSEALWAVTRGGAAALRRTDVGHLGIGAKADAIMLDAPDPVHLAYRPGVPLIAEVWISGQPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQY9</accession>
    <name>A0A010ZQY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848386.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080168_4_1_11"/>
    <dbReference type="OrthoDB" id="1857091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="23489" checksum="7B692C767A2CC145" modified="2014-06-11" version="1">MTVLPLPDELLLLAFDDAAGKPLVSTTTLDLGLAGAVLVELALAGRIAVEGKKVRVVDPSPVDDPVAEAALDRIRASGKERDPRTWLTPLTKGLRNRILDRLVETGVVEREESRVLGLFRTVRYPALNPAPETAAHGRLDAAIRHNDLSGRHTAALASLVHAIDLGPKLFPDLPAKEVKARLTQISEGDWAAKAIKDAIQAIQVALMAATTAAVTATVTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRV9</accession>
    <name>A0A010ZRV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.993"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25393" checksum="FB71CFCD16870596" modified="2014-06-11" version="1">MSKLLVVEDNPDIALGLKLLFERAGHNVEHAQDGREGLRLVHKVRPDLVVLDIGLPIMDGWQVLERVRDISDVPVLLLTAHGQERDKVRGLHGGADDYLTKPFTNGELLARVTALLRRSSAPDWSEEIYDDGRLQLDPVRRSVTVDGESVHLTPIEFRLLNTLARHKGAVLSPSQLLSQVWDDPTGIGAERVKFAVLRLRRRLGWSDPSDSPIESVRGVGYRYRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS02</accession>
    <name>A0A010ZS02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850771.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2514"/>
    <dbReference type="HOGENOM" id="CLU_027853_6_4_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022480">
        <property type="entry name" value="F420_MSMEG2906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03856">
        <property type="entry name" value="F420_MSMEG_2906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="28549" checksum="D093D38661AC60C5" modified="2014-06-11" version="1">MSTSAIRVGVQIQPQHADYQSIRRAAAEAEEIGADILFNWDHFYPLYGEPDGKHFECWSILAAWAEQTSRAEIGALVTCNSYRNPELLADMARTVDHISDGRLILGLGAGWFERDYDEYGYEFGTAGGRLADLAQALPRIESRLGRLNPAPTRDIPKLIGGGGEKKTLRLVAEHADIWHSFGDAPTIERKIGILRQHCADVGRDPAEIEISTAAEGKPADAGDTLYDLGVRLFTIGVGGPDYDLSALREWVAWRDERNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS36</accession>
    <name>A0A010ZS36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg-chelatase subunit ChlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2557"/>
    <dbReference type="HOGENOM" id="CLU_075304_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="122"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="30715" checksum="92E1404306A08E27" modified="2014-06-11" version="1">MLTGRGKRDRKGPQLPGSVAPGTTDEGSDLVTLDPSGTGPDPAVRARARQIAARLSLRRPRRDPRRHRGVGDLASLPYRDGSADLDLDRTLDALIGDPGGADDASGVDRRIIVRERVRTRRSVVLVVDVSGSMKGERIRTAAATVGAVAGELADDDLAVIAFWSDAAVLHPLGRPARPVDLLDLLLSVPARGLTNVGFPLQLAARELARVPARDARVLLLSDCVHNAGPDPRPTAARLPRLDVLLDVGTPPGEHDLELGRDLAHAGRGRLRPIHSHRDVAPALTSIFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSG8</accession>
    <name>A0A010ZSG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, permease component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2719"/>
    <dbReference type="HOGENOM" id="CLU_021838_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="369"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="566" mass="59686" checksum="CE4020A92159A02A" modified="2014-06-11" version="1">MAASTTIAPAPVEPSRARRPGWIVRAHASGWLLLLPALVALGILFVLPLLSVVVDSVTEPTTGLSNYASLFTDGYTLQVLGRTLLVAATVAVVGALLAYPYAYAMTLVGPAMRSVLVTLVLVPFWTSMLARNFAWLVLMQDGGVIQRFLRLFGLGDVTLLGSTTAVAISMTQVLLPFLVLPMYSAMEQIDGRLVAAGQSLGASRARAFRKIYLPLSLPGVVAGMSLVFVLALGFYVTPALLGSTRNAMIAQVINVRTKELLDFGGAGAMGIFLLAVTLLVLGLSRRLAGTTAVVGGSPTRSRGGGEQASAMRPWLAGHTVVVAILLVAPTLVVIPMSFSASPTFRFPPEDWSLRWYGELFSSPEWIAAILNSLQAGLVTALFATVLGTAAAFGLARLRPHWRGPLNGFLLSPMIVPHILVGLVVFAAFLRLSLNGTLFGIILAHTAVALPFVIIAVTARLQGMDDRLPGVAASLGAGPVSTFRKVTLPLVLPGILSGAVLAFVTSLDEVVIALFLQAPGATTLPVQMFNSVTVEIDPTISAASSLMVVLVSVPILIAQVWRRRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT11</accession>
    <name>A0A010ZT11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator of cell autolysis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_4_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14577" checksum="2E0DE0108FF1E9D3" modified="2014-06-11" version="1">MRALIELEPVPRSPRLARRFVADTLGPQADVELVDAAELLVTELVTNAVVHARSRARVLIVTTGDRGRVRIEVHDDAFEPPRMGSFDPDATSGRGLALVNAMSDRWGVEPQGPARPGKRIWFELEVRTSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT85</accession>
    <name>A0A010ZT85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851393.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2998"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_5_11"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="20728" checksum="2CAE17F909147437" modified="2014-06-11" version="1">MKLTILGASGGVGVELTRQAVERGHEVVAISRRPERGAVPDSPRLTRVPADVFDPESIGTALSGASTVISVLGLADRPGVLTAGSQAVLAAAPDRLLWLGAFGSGRSARAAGALTRTLLGTFLRAELGDKVAADTAILDGGGTVFHAGPMSSGPVSPRRRAVDLSEAPRKLFPASVSKATVAAAMLDEAEHPSGPGGRVLVPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTA2</accession>
    <name>A0A010ZTA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1495"/>
    <dbReference type="HOGENOM" id="CLU_097806_7_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="112" mass="11872" checksum="EB6D4DC81B9D4315" modified="2014-06-11" version="1">MKPDAEVTLTALSAPGDEVAGYTPAADLLRALASPLRIAIVMRLDEGALCVHELVDALGVPQPLVSQHLRVLRAADVVTSHRRGREVAYSLTDSHVAHVVRDAVAHSAHSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTB2</accession>
    <name>A0A010ZTB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851460.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3028"/>
    <dbReference type="HOGENOM" id="CLU_133235_1_0_11"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="15995" checksum="BA43E593DA7F09C0" modified="2014-06-11" version="1">MGQTLRLSAILEPRGPAGAFVLTDEQAAALGDGKKAFPVTVTVNGVTLALRLARMGGENMIGLAKAARAQAGVELGATYDVQISADAGERTVEVPADLAAALAADPAAESAFTGLAYSHRKEFVRWVTEAKREATRADRVVKTVEMVRAGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTF1</accession>
    <name>A0A010ZTF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851498.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3071"/>
    <dbReference type="HOGENOM" id="CLU_1352756_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21894" checksum="E64C5F3F36367E5A" modified="2014-06-11" version="1">MSPDLLVVPHTWLYAPRNPTLTITSFQEAPTPDGVACTATISVNDEAVGLLHNDGRGGATVFHSNGNPRFGPADMTAFVAACRTHNGGVLAAEWVFEELISSWSLEYAIQVARRTGHRVIRALDAIGEAESAESLVVLNGAHRLVGTLAGSGRDALIAHLTATSYGNEQRWWQVWTELRPRHGAWQDLTHRPAGVPADRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTL9</accession>
    <name>A0A010ZTL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2896538_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="6467" checksum="9808084E1AA928F5" modified="2014-06-11" version="1">MADSRLPVDALVAQSGHADLLVLGTHGWGGLAGLVHGSVTQDAFARANCPIVVIREPHDRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTX9</accession>
    <name>A0A010ZTX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3355693_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="36" mass="3894" checksum="C7E1FEC15586E1C6" modified="2014-06-11" version="1">MGLLGGPIVPDSRPAPEMFRRGEDAVLRCRSAGRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUC0</accession>
    <name>A0A010ZUC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569957.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1845"/>
    <dbReference type="HOGENOM" id="CLU_034641_3_0_11"/>
    <dbReference type="OrthoDB" id="1362354at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="370" mass="40466" checksum="9D7C08ABCFC892B0" modified="2014-06-11" version="1">MKLPDRFRLPSVFGVQVLLVVVFAVLWNPLDFFIYRLGGQVVGDGARLYLEQQAAHWFTYTPFAAVLFEPLSWVPLVPARVLWELVSVGAFAVACRQFVPWRWVVPGLMLEPVWHSLFLGQINLLLLALVAIDFRRVAAGKPAGIGIGIAAAVKLTPGIFVVLLLAAGRVRAAVVAGVTFGAATLGAWIVAPEASLVYWRDTFYDSTRVGVPYVSNQSPYGALTRLLGDVGSWYHVLPAVLSAVGIAVAVRYARRDDWLGAFAVAGLTGLLVSPISWSHHWVWALPALAVLWRDGYRRAFLATGAVLALSPMWATQFVDHPNDVWVLLPVRNAYLLLGLALLTHFAVRTAKRSGTAEAVPERVLATRDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUG6</accession>
    <name>A0A010ZUG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569966.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003696_0_0_11"/>
    <dbReference type="OrthoDB" id="1924374at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="28940" checksum="C672334CF3B6E188" modified="2014-06-11" version="1">MDLTTLAGDPTSEPDDLAGAVDAAAGEVAAFGPVLGLVEHDAPAVRTAVARALPHLAAMEINVPFAPFAVDALISLTADPHGDVRNWACFGLGTQMDEVDGTTVREALAARLTDRHGEARREALIGLARRRDPRALPAVRAALCRSDVWLLEVEAAGALGDSSLHPLVIRHLDGWDGGAARTVAAVARLTDPDGLGADLIDGLAAWYRSGGPLAVDADPGWWRIALDLLELAPYRATELASAVARCLGSDQHALDVLDDSTLGALARTHGWSGVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUI8</accession>
    <name>A0A010ZUI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849974.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1921"/>
    <dbReference type="HOGENOM" id="CLU_145919_0_0_11"/>
    <dbReference type="OrthoDB" id="1844113at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="15010" checksum="F56EA9590665846C" modified="2014-06-11" version="1">MKSESRIFNLLALFLFAMAAVYGVWTSKIDEGTEWVGVVALILSGLLCGMCGQFFSLVARRIEPRPEDRSDAEISEGAGDLGFFSPGSYWPFGIAVAASIAGLGVAYWFPWLIALGVIAVLFAVTGLLFEYYTRTGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUT2</accession>
    <name>A0A010ZUT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850103.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2027"/>
    <dbReference type="HOGENOM" id="CLU_016890_0_0_11"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="OmpA-like" evidence="7">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="31465" checksum="776068FD0C87AEF8" modified="2014-06-11" version="1">MSGGGHGGGKRKKHEEHEEHENHERWLVSYSDMMTLLMVLFLVLFAMSNVDQTKVIQLQEGFNQAFGTNAVLQGSSSVLQSSASDSAGLDLAAGSGPAGQMTESEQALVKKAVSAAELAKAQTRMLAAEAEAQNLTEAEKKIKAALKKSGLEGDASFTIDSRGLVVTVVTSSVVFSGDSAILRSGGQQILDAVGPTLKSLPNDIEVDGHTNQLPVPTRNYPSAWELSTARASAVVRYLISNEGIAANRLRAVGFAGTKPLISPSDVRSVKLNRRVEIIVLSDLPDDTSSLLPAAAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUV1</accession>
    <name>A0A010ZUV1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850135.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2047"/>
    <dbReference type="HOGENOM" id="CLU_054611_3_0_11"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="31357" checksum="B80BFA612A21D744" modified="2014-06-11" version="1">MTSYPPDGHVHTQFSWDAPLGDMERTCVRAVELGLPSIAFTEHADFGLTTLVDPHHDLPDWLAKHTDADGVVTPPALDVEGYLAEVARCRDLFPDLRILTGVELSEPHWHHRSATDLVTLGRFDRALGSVHTIRHTPELDYDAGDAFNALPADAVVRQYLAEVAELAAGSDVFHVLAHIDFAVRYWPASAGPCDPYAFEEEYRYALRALAGTGRALEVNTRNPLDPVIVRWWREEGGTAVSFGSDAHRPDLLATGLPEAAAMVETHGFGPGAHPYDFWVLKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV56</accession>
    <name>A0A010ZV56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850257.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_14_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="43475" checksum="0E701CD6CD65E6B9" modified="2014-06-11" version="1">MTPTEERATYTQVLAQPVFRTVFVTRTLGITADTLRVVALSTLVFASTGSPLLAAVAFGVGFVPQAVGAVGLGALADRVPARALIVTGYLVEAGAGLAIALLHPPVVVILLLVGGVALFTPVFTGAGNRLIADVLTGDAYVLSRSLAVVASSVAQLVGLAVGAATVAALSPTGALFATAAAHGLAAAWSALGLPAPTPPTPAPPRAGPAATTTDAPAPAPAPPPTASAPNAPVGDSGPGSGVGESWAGTRVLLADRRVRTLLLAHWLPPAVTTGAEALLIPYAERAHYPAGTGGLLLACSPIGMLLGNLAVGRLLGPAARERLVIALIGLSGAPLLVFAADPPVLVGALCLVLTGAGYAYALGLQRRFLDAVPEMRRGQAFGLLHAGMMTCQGLGPALLGLLTESVAVGTAIALAGVLTLTLAAALTPAVRRTAPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVH5</accession>
    <name>A0A010ZVH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3863"/>
    <dbReference type="HOGENOM" id="CLU_038134_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Flot" evidence="5">
        <location>
            <begin position="353"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="491" mass="51770" checksum="C26BE35B2539C336" modified="2014-06-11" version="1">MELLIVTAGGVLVVYLLVLLVLSRIKVAGPNEAFIITGRRGRSVTDSQGSRFTDLSGQKVVMGASVFVLPVVQRKQSLDLSSRRISVDIQGAVSKHGIRANLHGVAIVKVGGTEDAVRAAAQRFLHQQKEIDEFTREVLAGSLRAIVGRLTIEEIIGDRVAFASAVAEEAEHSMTNQGLVLDTFQVQDISTEGTYLQDLGRPEAARVLKDAAVAEATATQASEQARLLAEEAIATAERDLDLKKALIRAEVEAAQARSAAAGPLARAEREQVVIAEQQKVAERQAELTQRQLDVDVRRPADAERYRVEQAAEAARSADVLAADARRQATIAAAQADAEQARLTGEGERARRSALAEAAEREGQAEGAAALARGRGDAEAMRLKADAFARYGEAAVLDLLARVLPQVVEAASRPIGAIDKLTVISTDGASSLTRSVAGNVAQGLQLGTDLTGVDLARLLGRFKQATDETPPAPAPAPAPAPAAVRPSADGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVL5</accession>
    <name>A0A010ZVL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase involved in polyketide biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852660.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3899"/>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="OrthoDB" id="1186918at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28387" checksum="2158033B2A59964B" modified="2014-06-11" version="1">MTSGPKFDLQARLRTDQPAGARMWDYLLGGKDNFAADRAAADAVVARLPEMAEFARAGRQFLARAVAFLAGEAGIRQFLDVGPGLPTVSNTHELAQRIAPESRVVYVDNDPLVLVHARALLTSSPEGATDYIDADARDPEKILPAAAATLDFSRPIAVMMIGILGHIPDEDDPAGIVRTIVDALPSGSYLVINDSISTPQNDDAAETAHRQGAVDYTLRTVEQITAFFDGLELVEPGVVSNPRWRPEPGTDPAELAVYCGVARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVS8</accession>
    <name>A0A010ZVS8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">CryarDRAFT_2417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2380"/>
    <dbReference type="HOGENOM" id="CLU_063339_3_3_11"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="56"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="19430" checksum="DF240079DF1AE85E" modified="2014-06-11" version="1">MTVPSHGPIAGRVGGGPVTPAAVSDLISAHVVDVPDFPKPGVGFKDLTPLFADGPAFAQVIDVVATEHGGAFDVVAGIEARGFVLAAAVAYASGAGLVPIRKAGKLPRKTVSAAYALEYGEAVLEVHADAFEPGARVLLLDDVLATGGTAAAAISLVEQAGGEIVGFSVLMELAFLDGRARLGGREVHALLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW61</accession>
    <name>A0A010ZW61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine/D-amino acid oxidase, deaminating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850795.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2527"/>
    <dbReference type="HOGENOM" id="CLU_007884_3_2_11"/>
    <dbReference type="OrthoDB" id="1087129at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="34"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="447" mass="49040" checksum="2E003F555CA6B447" modified="2014-06-11" version="1">MHKSLADVEHGSFWLEDPGRPAATPPLTADTTCDLAVVGGGYSGLWTALIAKERDPSLDVVLLEGARIGHAASGRNGGFCASSLTHGAGNGLARWPSEFAELERLGMENLQAIEDTLVRYGIDAEWERTGELDVATEEYQLAGLHGPDFLDRDAVRAEVNSPTYLGGTWNRRGVAMVHPAKLVWGLAAVCRRLGVRMHEHTPVLSLRGTELRTPKARVRARTVALGTNAYPSPLVRVRPYVIPVYDYALVTEPLSDASLGELGWRNRQGVGDSANQFHYYRLTADNRILWGGYDAIYHFGGRVRDRYDARPSTYETLADHFFTTFPQLEGVRFTNAWGGAIDTCTRFSAFFGTAHGGRVAYAAGYTGLGVGATRFGAEVMLDLLSGEDTPRTRPRMVRTKPVPFPPEPVRFAGVELTRRSLAAADRNQGRRNHWLRTLDALGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWC4</accession>
    <name>A0A010ZWC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily protein, subfamily IA, variant 3 with third motif having DD or ED/beta-phosphoglucomutase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850867.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2597"/>
    <dbReference type="HOGENOM" id="CLU_045011_4_0_11"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="25597" checksum="EAF10D1076B923CF" modified="2014-06-11" version="1">MTLGLPPTIRACLFDLDGVVTRTAAQHATAWKTMFDRFLADYAPDQRPFGIEDDYVRYVDGRKRLDGTRAFLVSRGIDLPEGTPDDTLADHTVLGLSNAKNTLVLRLIEDEGVEVFDDAVAYVTALRAAGLPRAVVTSSANAQQVLEVTGLAPLFDTRVDAVVAAERGLAGKPSPDTFLAGADLLGVAPGEAAVFEDALSGVEAGRAGGFGFVVGVDRVGQAAALTEHGADVVVTALTDLQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWF8</accession>
    <name>A0A010ZWF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035865508.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4185"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="831"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="893" mass="93913" checksum="ACBD7753F38CFDF7" modified="2014-06-11" version="1">MRERLHGRDEELGRLDELVAAARDGRGGALLVVGEPGIGKTALLSALTGPRVIRLEGYEAESAIPFAGVHRLVLPLRDHIPGLPGRQQEALQVATGLADGPAPDRYLVGLGVLGLLAAAREPVLGLVDDAHLLDAESLEALGFVARRLEAEPVAFVFAARDELPLAGVPPIHLRGLDPGSAATLLRSVSGERIDPATAARIVAATGGNPLALIDLAGELSVKQLTVADEPIPVGGRLEQLYLRQVRSAAPARQEWLLIAAADSTGNVDLVRAAAAALGLPDTAGDEPDLAGLVELGRSLRFRHALVRSAVYNGVPGAERRRVHRALSAGAAGLGLVEQAAWHAAKATVGTDPDVADRLEQVADLAGRRGGFRSRANVLTEAARLTPPGPVHDRRLVAAAEAALAAGAAGLAESLVEELTADTVDDVTRGRLISVRVAHAFFTGDPAIVRGAGEMLAAAACFSGHDVAAEQDALIMAFNRLLPVERRNTDVPLPTLGRRLLDGAALADGVAGTILRAFGTLLLRPYREAVPELRAAAAVIDSLTGADLIKYGLVGVPLHTALWDDGAIRRVVDRVVATARDLGSLQVLDTVLWTMSLSLLSIGTPRESEEHMARVRRLRRALGWDAEHVVNGALLAWSGGPRDQVEAIADGALAVGWGGVHAAGVSALGVRDLAERRYVDAYTRLKPLVDAPFLHVTPVNYGDFAEAAARSGHPDEAAAITATLEEIAAANGAPWATLVARRSRALVTDDEACYAEAVDLPGPPVERARAHLVYGEWLRRVRRRREAREQARRALEMFEDAAAPAFAERARAELAALGTRSGGALPATPSGAPPSGARLTARELAVARLAAGGATNAEIGAALFISPNTVDYHLRKIYQRLGITSRRRLGGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX68</accession>
    <name>A0A010ZX68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851258.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2894"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="22379" checksum="2A0DFFFA3BDA1B9A" modified="2014-06-11" version="1">MTGLVVVTGAAGALGRAVLADLTARGRTVVALDRDGAAPEALDDVHPIAVDLADRASVLAAWKRVDEIGTPSGLVTLAGGFAPGRLADLDEDTFTGLWEGNVSTLLWSAQQAASRMPRGSSIVTVGSKTAVAGKAPVGHAASKAAVVRVTELLADELRPAGIRVNSVLPSVLDTPANRSWLSPESAAKAVSTAAVAKVIAFLLSDDAAPISGARIPVYGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXK8</accession>
    <name>A0A010ZXK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional DNA primase/polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851477.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092810_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21087" checksum="9ABD9F4F2E39CDD8" modified="2014-06-11" version="1">MASLARAAHEYLVAGWPVLPGAYWSPQTCTYRCGRPGCDNGSPHPVDRGVPGRCGQRVPLRSIAADEVGQWWNDRGFNLIMPTGGPGATVVEGPARFVAAIEARLADDGCPLAPVLALPTGERQLFSAPIPVDDELWLATAMGGATLHGDGGWVTLPPSIVSGGRLRWERAPETIGWRLPPATAVRTALRAVLDPGRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXQ3</accession>
    <name>A0A010ZXQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851513.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372891_0_0_11"/>
    <dbReference type="OrthoDB" id="294150at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="745" mass="80975" checksum="9CDDE9ABF3BD11EF" modified="2014-06-11" version="1">MTDLFAEGVVSQYVRDDPDFVPRPWFADRFEAALQDPNCRYLLLVGEPGAGKTAALAWLADHDRQSLRYFVRRDSRQPLSAGDAQSFLLALGHQLASRRPSLFRPDRLRIAVRQRIDALRAGARAVGIDVEELVLSPFYQTAIQVEQDVRIAAGEVIGVRAGRAVLEDRLLSPESLQYLALLDPAAVLAAEDPAARIVIFVDSLDELRYHLGGPTILSWLENAPQLPANILVVLASRPDDSLLGVFRDRQRQWLQEHHVGADLGVVNQDALQFARRRVANPIIRRAVSRAGADENAFVARTVDLAAGNFQYLSALYRGIQASEQASLDELPEDLTGLYRFFVDQVAGAMRDQWVELPSGDLAQPAHRMPAWEGSVEPLLTLLAAAFAPVTRSQLERFLPDRPLVSGLRVIRQFVREHDGGYSVYHDTFRDYLHERLNVTDGHRRIASSYRAGQATWSDVEWSDADEYAMSYLAQHVSALVAAGAVSLRELDDLISRPLMLEKSRRYGSLESFAVDVRLAVDTASRISGTGALVAEVRARWLLANLAAAALSVPEDLIAAAGRAGASRLAIGLAESVRDPSGRAVAFLAAGMELVRAGEHAIGCGALRTSLAVMDAAGFFPIPAISRMLGGFAQAADRAGVDLVVEFIDRADPVQPSPEQGLLADVIDAYAVLGDSVTCSDRATRLMFSDTAALTTVCRALAKVGDHELAMRLAERSTARVAVGSEVAEQMVLEGSIADGAELGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXW2</accession>
    <name>A0A010ZXW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862961.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3148"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="33886" checksum="7E0C80749EEBF504" modified="2014-06-11" version="1">MAQVLVTGGSGFVGAHTVVRLIDAGHSVRTTVRSLRRVDDVRAMVARPGAALTFVEADLAADTGWARAVDGCEYVLHVASPFPAGEPSDADEVIAPARDGALRVLRAAHAAGTRRTVLTSSFAAIGYGTTLTRPYDESDWTDPTDDLPAYIRSKAIAERAAWDYAAAAGVELAVINPTGIFGPILGPDYSTSIGLVQAMLNGAMPTVPRASFGVVDVRDVADAHIRAMTAPDAAGKRFLCTSEATDDPFAGAQCSYLEIAHILRRRFPERADRLPAGEAPGPEAPAKAYRIERIRTVLGWKPRSAEEAVVATAKSLLALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXY3</accession>
    <name>A0A010ZXY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851628.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3171"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22550" checksum="21BCF3384964C2AC" modified="2014-06-11" version="1">MRVLIAEDQVLLREGLVQLFTARGHDVVAAVGDAAGVLSTVEAHQPDLLLIDVRMPPTFTDEGTRAALDVKHAHPGIGVLVLSQHVDTTHAPSLVGLGGFGYLLKDRVLAVQEFLAAAQRVADGGSALDPTVVGALMAAHPLSSLSAREREVLELMAEGLNNPAIARRLTVSERTIESHVRHVMLKLDLSESDDGHRRVLAVLAYLRAHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYG4</accession>
    <name>A0A010ZYG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725916.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16604" checksum="5DAB2DDC331799C7" modified="2014-06-11" version="1">MSRRDELIGSIGDLLRLQSGLALVLHQAVADQFGLNPTDLKCLDLAAREEALTAGRIADVTGMSTSAVTALLDRLEKRGFVERYRDAADRRKVYVRSTGQHEEKLAEIYGPLSDATDSVLRSFDVKSLDAVRDVLSQLADVSQAFIRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ05</accession>
    <name>A0A010ZZ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3594"/>
    <dbReference type="HOGENOM" id="CLU_038663_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="45"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="497" mass="53714" checksum="56CBAA69D60EA3D0" modified="2014-06-11" version="1">MARTRQHRPRPSLRVPSGVSDALVRLSTPRPVATPPAAAPRRELYLDALRTAAIVRVVTYHAFGGSWLSWVFPAMGIMFALAGGLMVRSLDRQPPLTVVRNRFRRLLPALWLFGAIMVPLMLVHGWADDEDSPLSRPGLLFWVVPVFDPPGSTWGADATAPLWYLRTYLWLVALSPLLLGAFRRWPLPTLLAPLTIVVAAAFGLVPDQNHGQLWDLLVSLGMFAPCWMLGFAHRTGALRRIPKSALLGVAAVCAAAATGWALTHPGDDPGATYDLNEIPLADALWSIAFVLPLLRFAPDASRIGRTPVLGRVVTLVNNRAVTIYLWHNVMIGLSFVLEDTIESVFPGAAPLTGNAVWNYAVIWVLVAICVVVFGWVEDLAAGRTPRLFPVGPSAARRHPERAHVTASPESTTAARAQVQPVTPVRAIGIAGDQTRIAPHLFGAREVAWSPHPNQMFRPGSHPAHHGDPSSGDLPDPPTTGQVVAPGLRGGAATPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZK0</accession>
    <name>A0A010ZZK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852582.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3819"/>
    <dbReference type="HOGENOM" id="CLU_056519_1_1_11"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="59"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="33463" checksum="4DA0E5B3B2713695" modified="2014-06-11" version="1">MDQITLGEVTITRVKESYGSVGMTPDQFFPGTDRALWEEHRDWVVPDFWHPETDECHNAIQTWVVRSEGRTILVDTGVGNHKERPYVPNWSHLDTDFLDNLAAAGVRPEDVDVVINTHLHIDHVGWNTRLDDRSWVPTFPNATYLIPQKDFDFWNPANENASVFGRGNQNVFEDSVLPVHDAGLTTLWDDSYRIDGNLRLESAPGHTPGSSILVLESGGDRALFVGDLLHTGVQLVDPDVNSCFCEDPTEARTTRRALLGQAAETRSLVFPAHFGGHGGAEITHEGSGFAVKDWAGFPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A091</accession>
    <name>A0A011A091_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Coenzyme PQQ synthesis protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pyrroloquinoline quinone biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pqqB</name>
        <name evidence="8" type="ORF">CryarDRAFT_4111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the transport of PQQ or its precursor to the periplasm.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PqqB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4084"/>
    <dbReference type="HOGENOM" id="CLU_061120_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00653">
        <property type="entry name" value="PQQ_syn_PqqB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011842">
        <property type="entry name" value="PQQ_synth_PqqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="49"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="28826" checksum="8D07523362491C22" modified="2014-06-11" version="1">MIARVLGSAAGGGSPQWNCHCTVCTAVRAGAGPPRTQSSIAVTLDRDDWFLFNASPDVHRQIDGLTVAAVLLTDAELDHTAGLLLLREARALRLYATAAIQRTLRDGSGLLPLLERYCTVEWIPVELGVPFPLTPGLTCEAFDVPTTKKDRFGVNVSEGRVVGYRLTDAGGTLVYLPGAQSLPEFGPCDCLLLDGSFFRDDELSATRTARDMGHLPIVDSMPSIKAPRTIFVHINNTNPILLDDSPERRVVEANGMEVAMDGLEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB04</accession>
    <name>A0A011AB04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847699.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.211"/>
    <dbReference type="HOGENOM" id="CLU_094585_0_1_11"/>
    <dbReference type="OrthoDB" id="1635683at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="14454" checksum="0EC64C990FC95451" modified="2014-06-11" version="1">MSSLSHDAQNLNWLVANFANRVPGIAHAVAVSADGLLLAVSDGLPRDRADQLAAIASGLVSLTHGAALCFEGGSVSQTVVEMDTGFLLVMSISDGSSLAVLASRACDIGQVGYEMALLVERVGQVLTPALRSELHASLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB36</accession>
    <name>A0A011AB36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIIE-like protein with GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.238"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_32_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="456" mass="48278" checksum="CEB72E89A787D52D" modified="2014-06-11" version="1">MVTHTARHGHSGYAPLVVELADEVFSAVRLAAVRRSELIGTGTEASFDRLAGLAARLLRTPFAFVTIVDDQRSFWKSCIGVNATDPGERQNPVGESFCQYVVNSGEPLIVGDVTRDPVTAGNPSIEKMGVRAWAGFPVHSPDGQILGTFCVVDTVPRVWTDDDVQVLETLSRSVSGEIALRAALAEARTAAADSALLAETLQLSLLPPALPVAPGLDLAAAYHPGGRGSEVLGDFYDVVPSRRGSWSVFVGDVCGKGPEAAKTTALARYTLRAAALQHASPAQVLGLLNPALRDWFGTNYGRFVTLAYTTIRATPRGCTARIATAGHEPVALRRRDGTVELIHTRGPVLGVIPALTLTERRVQLRPGESLILYTDGVTEARAPRSTEQFGPERLQKTLAGAEVSDTAADLATRLMDAVLDFGGTITSDDVAILVVRVPPAGPPSVPPTSVQAVMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABE3</accession>
    <name>A0A011ABE3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847886.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.339"/>
    <dbReference type="HOGENOM" id="CLU_065796_0_0_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="245" mass="25794" checksum="84200467CEC6D73D" modified="2014-06-11" version="1">MTILGIDIGGSGIKGAPVDLDTGALTAERYRLETPKGGAPDDMMPVIAEVAKQFPGDGPIGVTFPGVVVRGVVKTAANLNKDWIGVDAGTVFTELTHRPVTVLNDADAAGVAEMAFGAGRDRKGTVLLFTFGTGIGSALFRDGDLVPNTELGHVELHGKDAELRASDRIREEYDMSWSKWAGRVNEYLSHLEMLFSPDLIIVGGGVSKKAEKWLPEVKVNAEIVPATLQNNAGIVGAAMAAATVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACA9</accession>
    <name>A0A011ACA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.705"/>
    <dbReference type="HOGENOM" id="CLU_726900_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="43978" checksum="C19A1FA93B588522" modified="2014-06-11" version="1">MTSPGSGSRLRSAPLRAFAPLALQLITVISVIALFALVWGTRSDDSDLHSRERDGVEYAKALDKLLPALVNAQSNAVSGKPVKKEDFAESLNAVAEVDEKFGSDFGTSNRWSGLRARIETLPEQGGDQNGAFKNYGEATDLLLALYQRVAQASGLRSDADGVISYLQDAALEEIPLAVVWAGRYQDQAVIAGGLPDLARDAALETFNDQLSQINNALTSLAVSRQLVSESGADVAADMASAVDNSDSGTFSTTLLQNLDNFQRGVETLAPPGQTTLNSLPTANTVTSQRIAAQEAAVALSPTLLDELGKQIDDRKSTADTGRILAIALLVIAVLAAIASFVLILLGGRRSRAESIDGPGPQGPQAQPGPRGQQQPYGQGNPDYAGYPAGPDQMGGDPYLNNLDAGRDARRERVGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACG3</accession>
    <name>A0A011ACG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569706.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134269_2_0_11"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="14495" checksum="091C8295F07C7DF3" modified="2014-06-11" version="1">MKLSEALYRTVVNWDDVPEDVIRPGVRRRVYSTDEVMLCWHSLSVGMDLRPHSHADFDQLALILAGEADYYIDDVPHRMTAGSMLLVPAGAEHYIKPLTEPCINLDVFAPPRADYADIARKLTDVLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACR5</accession>
    <name>A0A011ACR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.866"/>
    <dbReference type="HOGENOM" id="CLU_092792_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="23779" checksum="343AD7E3BA5030C7" modified="2014-06-11" version="1">MQRARSVEAKQQREQAILEAARRLGLERGIRQITLTDIANAVGMHKSALLRYFETREQIYLLLTAEGWREWGPDLLTRLAPWTPGGASPERIAEEIAESLVSRPMFCDLLAQAPLNLERNVSLESVREFKLVTLEQVEAIVAEFRRLRPGLTEEQGVDLIATATSLAGALWQMATPGPEIEALYRSDPRLGHAIVEVGPRLTRVLTAFLRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD35</accession>
    <name>A0A011AD35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725660.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1002"/>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_11"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="53972" checksum="12A027F196DD99B3" modified="2014-06-11" version="1">MSADRPHILVVGGGYVGMYTALELQKKAKKARITVVDPQPHMTYQPFLPEAAAGNLEPRHVVAPLRKTLRHAHIITGYVDSVDHAHKTAHITPVVGNPYELTYDHIILAPGSVSRTLPIPGLKEHAVGFKTIGEAIYLRNQVLGELDAADSTDDPELRKAATTFTFVGGGYAGIEALAELEDMVRDAVKYYETLSQSDIRFVLVEASQRILPEVGPEMGAYTVQRLLDRGIDIRLNTFLQSCEDGIVKLSDGDEFPSRTVVWTAGVKAHPMLANTDLPLDERGRVTCLPTLQVVDPDGNVVEGAWSAGDCAAVPDLSSETPGATCSPSAQHAVRQAKRLGANLGILLNGGQPEDYRHKHVGSVASLGLYKGVAQVYGIKTKGFAAWFMHRSYHLSRVPTFNRKVRVLADWTLALFLRREVVALGQLHDPRASFELFATPTPAARPTATPAAPAGGKAGDAESAKPAAKPAETAKPAETVKPAQPTEAVEVADEAPEKAPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEI7</accession>
    <name>A0A011AEI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2478099_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="87" mass="9107" checksum="5A01D668AE980499" modified="2014-06-11" version="1">MPELGSRSTTLLTFLLRLPRLVLILGVMALVLAGAFLPGVFGAAFIVLIAALVAWLAWLGWDSAAPMARLGRAAVVGVLLLLAVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFE6</accession>
    <name>A0A011AFE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849779.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_8_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="127"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="656" mass="69945" checksum="9C726276E8DDFD4D" modified="2014-06-11" version="1">MKRARRALLRRTVQGRRRIWIAGRSRWPVAALLPCAAGVVILGTPTGDVMPAFLLLFAVIGATVIGGRGPGVLAAVVATAALATTFVVREATPQPDGRWAWAVVFLGLTVAAVAWVDNLLSDAARRATALLGPLVEAAPAGIALLDRDLRFVQANSALAGLTGRPAAEHLGRSLTDVLRDAPDELVARLRAVVTSGAVVRHEPLEATARSGPAHQLMVDAFPVRLPGDAEGVITGVGVVLTDVTERNRLEQLEREAEQLQVTARVTHRLLESQRIAQLAGFEISLSEPRYVWSAELCALMGRDAPPATDEDAVAHIHPDELERVLAVQSRALATGRPFTLETRMVRTDGAVREVLVHAEAVRADDDPDAAVVGLWGVAQDVTDAKAAEDELEATQGELVAAQRDVADAREEIEAERLLLELFQRAMLPAELPDVPGGDMKADYLAVADRIDIGGDWYDAFGLPDGRIALSIGDVVGHDQQAAAIMGQVRAVNRGYMLEHPDPGSVLSRLNRLMVVAYPSGTLVSAVVFLYDPGTGQLDWSNAGHPFPLLAVPEVSVLKSADPILGASVGRTYSTHTVMMPEGSTLLSYTDGLIERRNTDLDRGQEKLIGMLSRIVAGGAAVSAQTVIDQVTVGMTAAETLEDDVCVLALQRHVDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFK1</accession>
    <name>A0A011AFK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849866.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1844"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23006" checksum="223FE338FA0C6BE0" modified="2014-06-11" version="1">MISVVLADDQPLIRSALRVLLAETADLELVGEASTGTEAVALAREHRPDVVVMDLRMPELDGIAATAKIAETLPDTRVVVLTTFDDDEYLYGALRAGASGFLVKDMGLDDILAAIRVVAGGDALIAPSVTRRLVDTLAGRTPAPAARPSIAGVTDREREVLTLVGRGLSNAEIAAELFISIATAKAHVARLLTKLDARDRVQLVILAYQFGLVSPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGM4</accession>
    <name>A0A011AGM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850360.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665184_0_0_11"/>
    <dbReference type="OrthoDB" id="1866964at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="420" mass="44313" checksum="07128E68CC3F6E90" modified="2014-06-11" version="1">MPDAFEASLAEVLHRAADAAPEPVSDAGEALLRESVRRTGLPRARMLTLAAAITVVIVLAAVVTVLKLVSGDEDMRPVTPPVRIVHSDYEDGAPLADVWPDAVRTVPATIPINGRPNPFNVEGVLPDGQLLLTPVGDEPGIAHLWALNPSTGAARPVSASGEWVVVVGQQIDAGEARWIAWISQPPGAVEPDSPVYLWYAPASGGKARKASSAPISTSGGVDLSAVRVLIDGDTLIVTPALTKEKGQAESAVRTVRIGENRIRTVPDAAGMTVVQWPWLSDARTPGHRTIRNAETGQVRPARLPADWTDVDCSLSWCVGRRGDRLVVARRDGSDARPLANGGPALGVVRDRFLFVAGRTVYDLQTKKTLTLPAAAGGPDTVWQPLGIIGEGGGTPMLAWATSDATGQLESYLLIDTQAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH05</accession>
    <name>A0A011AH05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850543.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2343"/>
    <dbReference type="HOGENOM" id="CLU_041141_1_0_11"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="34088" checksum="01CAD57C67ED9E5E" modified="2014-06-11" version="1">MGHTSARLLALLSLLQARRDWPGEALATRLDVSPRTVRRDVDRLRELGYPIRAVKGPDGGYRLDAGTQLPPLLFDDEQAVALAVALRIAVTSGAGIEEAAARALTTVRQVMPARLRHRIDALELTAVGSAPQADTAVLLAVAAAIRADEVLRFDYSGAVRRVEPHHLVTRRGRWYLVGWDRDRDDWRTFRVDRIVPRIPTGPRFTRREIPGGDVATFITARFRGSDTPEWPCRGEVVLAAAATAVAPFAGDGVVEALGPDRCRLVAGSWSWIGLAASLGRFDADLEVIGPPELRRAFATLARRYDATALRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIA6</accession>
    <name>A0A011AIA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570169.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2802"/>
    <dbReference type="HOGENOM" id="CLU_070066_0_0_11"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="378" mass="39600" checksum="6E58348758A4028F" modified="2014-06-11" version="1">MNWSVVIPTIGRPSLAACLDGLAGSVRSPVEVVLVDDRPLNECGPLPVEVPPGLDVRVEYGCGNGPAAARNVGWRSVTTPWVVFLDDDVVPGPAWASSLETDLASADATVGAVPGRIVVPLPGGRRPTDAERTTAGLAESKWITADIAYRVAALAATGGFDERFRRAFREDADLALRVLDAGWSLGAGQRVTTHPVRPDGPLASVRAQAGNADDVLMTRLHGPTWWDRAEAPRGRFTRHLVITAAAATAVTLATAAARRRPGPSAGALRRTGAYGVLRRTCAPGASRGRAGRADGCRRVAAVAAAVWAAGTAEFAAARIAPGPRTGREITTMIVTSVLIPPAAVAHHLRGRWRHRRAGPWSAPAPVSPPPGDRVEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIJ6</accession>
    <name>A0A011AIJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-dependent enzyme, putative carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851275.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2908"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_4_11"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="185"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="372"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="533" mass="55186" checksum="5A4ADE84273287CD" modified="2014-06-11" version="1">MTSVADVVGALVGRLGARYAFGVVGSGNFHVTNALRNAGVEFVATRHEGGAATMADAYARTSGVPGVLSLHQGCGLTNAMTGIAEAAKSRTPLLVLTADTAASAVRSNFRIDQDALVRSVGAVPERVYGASSVADDVVRAWRTARDGRRTVVLNLPLDVQAQSAELGDVPEVPAPVPVRPGEAAVEALAAAITAARRPVFVGGRGARGHGPVLRELAARTGALVATSAVAKGLFTGDPFDLGISGGFADPRAADLIRGADLLVGWGCSFTMWTLRHGRLIGEGTRLVQVDDDLAALGANRPIDLGVHGDVGATAAGLLPRLEQREGYRRPGLLDGGPGWGPFDLSSADRIDPRALSAELDRRLPAERTVAVDSGNFMGYPAAFLGVPDEAGFCFTQAFQSIGLGLATAVGAALARPDRLTVLGTGDGGLLMAAAELDTVARLGLPLLIVVYDDAAYGAEVHHFGAGADLSAVTFPETDIAAVARGYGLRGATVRTLDDLRVLDTWDRRSALLLDAKIADDGGSWWLAEAFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIW7</accession>
    <name>A0A011AIW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851479.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3046"/>
    <dbReference type="HOGENOM" id="CLU_154638_1_1_11"/>
    <dbReference type="OrthoDB" id="1859412at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="98" mass="11127" checksum="4D77CFDA48227140" modified="2014-06-11" version="1">MEFEFDATVWEWRGPAPYHFVSMPGEHAESVREVAAAVTYGWGMIPVRVRLGRTTWRTSMFPKDGGYVLPLRDSVRAKEKIAPDDVVRVHLVIGRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJQ5</accession>
    <name>A0A011AJQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570379.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1987856_0_0_11"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="13128" checksum="2E47174805F90496" modified="2014-06-11" version="1">MAWSTRELAELADTTVNTIRYYHRLGLLAEPKRRYNGYKQYDAEDLNRLLCIRRLVGLGASLSQIAEVLADQHLTAKILRQVDADLAAEVDRLHRARCDIAVILRDSVQAPAPAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK48</accession>
    <name>A0A011AK48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3478"/>
    <dbReference type="HOGENOM" id="CLU_244757_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1589" mass="169135" checksum="2BCD151A2A180B8C" modified="2014-06-11" version="1">MTPDGSWDAARVGGIQRASSGTLKVFVSFTADDASWAEWIALALRDAGYDVIFQPWSMTPGTQWPSKVDEAVEADHTVAVVSAAYLDSAVCRAEWTAAWARDPVGDTRRLIPVRIEDCALQGVLPQVVYSDLFDVGRTPVGRDRLLTAVAGGPVVAAAAPARRRDHLDRQRVRIRQYPPAGGLLGRESELAELSAFCRGEAPYAWWVGEAWAGKSALMSEFALKPPDDLEVVSFFVDSRRLAEATGAEFVESIGAQLSDLVTAGQADAAIGSFGESWLMLLEQAAERVRRSGRRLLVLVDGLDEDRRSAGVPSIATLLPIRLPDGVRILVTSRPEPGLPADVRDDHPLRACTPRRLAQLGYAADDERRAGQELDVLLDTEQVHGGLLGLITAAGGGLRPEDLAELAGLTLRDVERMLGSFFGRTIVRVAAEKGGAADGGGSTLTFAHAALQATAEARLADRLPGHRREIIAWADAYAARRWPAGTTPPYLLFDYPGMLRAAGEQDALTRLATDAFRHDRLYAETSSDAAALAETREAHDLICATGRPAVADLTVLAGVSAARDRLLHRNRYLPVTLPALWLALGDRPRAAALFRSITDLDRSKEAQRALSRADPSPEPSATPLNEYQWIQAVARAIGSAVDPARLVAEVLRMAGRITDPYQCADALTMVVKSLAEADRATLAEPVIEEAAARAAQLVESKHVQAITALARAVAQAGQVARAVTLARTVTDQREQGRVLLALGLALIDLGVYSGAESVGVSLEDGPQRGRVLAALAAALAESGELHRAEQVAHRIGHPYWETAAWLDIAEIARDKGDRSTMDKLMRRAGRSERQIPPDDATSQDNIRFRRASALARQGDAVGACKLLGRISTPRVRINALPRVSKLVAESQQPAGAISVLRLYGSSPGYAKARVRATTEVVALLARRDATLARELAGSIRPPERRVEALVSLAQVHLANGDLGAADAVVAEIPTAEGRASGYAAMLRLADETDETRMRTLAERAVRCCASIGSRERRSATLVLVAGAALDRGLMDVARELAGRAEEVVRHDDEAEAVLDACAAARAYQEPDGPAGLLLAEAQRRLDLIGDRERWLVAALEVAKTAQDVGDQDVAWRAARAVAAPYRPGQCVADLAVALADAGCLDLAEQHALAVRPARQQADALAAVAGAAASAGQDAHCGTVLDKARRAADRVDDLADRVEALGTLVAVAKAAGRRQQAWSLTRRAEGVIGTISHPGQRAAARARLAAATAPNAPRRTDRTTTEAEADLLLDPGERSAALRDLACAAAGAGDEKRAQALAERAAALIPPSIGTEWSMGVQTGLARIALTIGDHDLAHAVIWAMRDGAERTRLQLTLAEALADDDDFAAGGRAPTRTAVPGERSSTGTAAENPALAAVAEARRLVAEDGLAAAEQWAATLTDPRSRCVAFTTLVEAAGERPSETRRFGEEAARWADRIEDSKLKARALAALARTVARTGDRVSARELTERAKAVRVARQTEVLVELVKTMAIIGDYQRCRQLALLMPQPQSSRALVAAAGERSDHEGLLPIVCLALRNGSWRTVVEDPQALPADVVTAIAAAARNRLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK64</accession>
    <name>A0A011AK64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852089.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3495"/>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458414" evidence="7">
        <location>
            <begin position="37"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="208"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="732" mass="76090" checksum="21CB823AC17D95E9" modified="2014-06-11" version="1">MATLLYRIGRLAFRRRRWIAAAWLAVLAATLFGASALEEPTKDSFTIPGTQSQQAMDLLAERFPEASAGGATARVVFAAPDGETLRDPAYRRAIDTAVAELKQSPQVAAVADPFSADAVNEDGTIGFAEATYEVPGDEVSDGAHDALTSVLERARAGGLRVEAGGDAVAGEDEGGFTEIIGVVVAAVVLAITFGSLIAAGLPLLTAILGIAIGIGVITAASGFVDLSSETPTLALMLGLAVAIDYALFIVSRYRHELSAGREREDAVGRAVGTAGSAVVFAGLTVIIALAALAVVGIPFLTQMGLAAAFTVAVSVVIALTLLPALLGFAGRRIRGDRKSGQHTHFSQTYSRPTLGARWVRMIARRPLAVLLLAVIGLGVVALPTLDMRLGLGDDSTASEETTQGKAYDLLSEGFGPGFNGPLIVVVDARSGTASQAAEQVATRIHDIDDVGAVADPAVNEAGDTAILTVIPDSGPSTDATKNLVRAIRQQDGLVPGATIAVTGLTALNIDISTKLGDALIPYLAVVVGLAFILLTLVFRSVLVPLKATAGFLLSVAATFGAVVAVFQKGWFAGALGVDQVGPITSFLPIILIGIVFGLAMDYQVFLVTRMREEYVHGAPARSAVIGGFEHGARVVTAAAIIMISVFSGFVLAPAAFIKSIGFALGTAVLFDALIVRMTIVPAAMILLGKSAWWLPRWLDRLLPDVDVEGEKLRSRLDGAPQRVRSAPVRVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKD6</accession>
    <name>A0A011AKD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3575"/>
    <dbReference type="HOGENOM" id="CLU_016093_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="940" mass="99826" checksum="6024752179271BC0" modified="2014-06-11" version="1">MSDPMFEQLISCVEGGHVEQATDALLALSESERRALAPRLKAYRPDRPAFPQYEDSGPSLDLREVHDRYQRSWRRHETLERNREDVLRIAGAACLPRAADVVTWLRSDRFWRTPSLAAVAALTRVVSAPGRPAPASVARPLADRLRPAQVDRHWPMVSGLLTAAGLAPPPTEAVVRGWIREIGRVDVTERLRAHPHTALLLPHVFRIPRVAAELREEWPPALARLVTDGHYPRAVLLADVLLRLRIGDRPGAVRVVVRVHRSLAPTTAEYAEHRQEYLGMLSSPHVTVADSALVALRAADDAGRLPADAISEAAYAVLPRPEKKLVRTTLGWLDAVLRRTPDPHVFAALTAGIGNESVDLAERTLTLAARHLPTFGAEGRAMVRDAADALDGDLRRQAYALLDGPHVGTAAAAAAVDVDRTAAHPAPPPIPAPIPPPAPIPPPALIPLPLPAPMPVPIPRPVPIPRPVLIPRPVLIPRPVLIPPPAPMPPPIASVAELAAAGASLLRNRADPLVFERFVAALPVFVRADRAAVSAALTPLLPEWTDSVVLMMRSAVTGVCRGYALNEYERNPAHLSHLTARRAVELAEQLAGEPPAALLATPATVDGHVDPVRVLDLVAAAEAAGTRPGPYDLTQALLRLPRVVEPRVAEAAARLRSPAGRALARWLAGGGLADPDIRIVDVPQQRCRHGNRFDEAYLPCGCGPTRAYRRTATFPLLTHPDLTLPPELLSRPPEHADGFHYVLSAVPWPLAAPSHRELVAAHLQPLLAGASDGSVRSDRGALLPSLARASGPLGPAFALCLAYGLTLGRPAERLAAADAFVITAARADLGGADVGALVGHELAALHDAGLLVLRRVAEALTGALRAGAAAEVWAAARALVPAALTASAGGPDLLALASAAASAVGAHETIPDLEDVALRGGRTRLVTEAGRLARTLAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALB6</accession>
    <name>A0A011ALB6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852658.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3895"/>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid_dh" evidence="5">
        <location>
            <begin position="153"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="38513" checksum="C4E169D1DE87D60F" modified="2014-06-11" version="1">MTEIRIPRLNSNDTEYTLVEWLVATGEPVRPGDLVATVETSKATEDLTCAGAGVLQHLVAAGTECAVGEVIATVLPVGTRVSASPAGVSPAGVSPAGVSPAGVSPAEVEPIITEPARRAMAERGIGLAAVRALGRPVIRVADLDALDPAGPGRVEPLSSVQQAVAAVVSDSHRSVPAGFVAIEVPVDAALHQARELTRTHRCLIGLTELVIAALGTVAERFPQCFGAYVEPGAVRLPDRVDVGVTIDIGLGLHVPVIRDAAAKPVAVIAKELMAHRLTAMRGSFRATDLTGANVLLALHTDDGVTTAVPIVLPGTVCAVSLAGVRPVLRLDADGAPVTHTVVSLGVAYDHRVVNGAKAVEFLRAVREVLLAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG67</accession>
    <name>A0A010YG67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847741.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.243"/>
    <dbReference type="HOGENOM" id="CLU_640768_0_0_11"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="489" mass="53011" checksum="1B77C291481524E5" modified="2014-06-11" version="1">MNVTAPVLHRTDAGLRPDPSRVVARLFLPGEELPRVRSRVGAVVTRVLALPDDEVEQITADLLSDYSTRHRGYRAMLVEHAAVVRSHIGRDVELSDDRTLLLGAAFTAEFAVEGAALCNPSAVLAPDQSGTAPGQVRVALSLRSIGEGHFSSIGFCSALAGPGPIWSFEDRARPLVGATTTPSRWRIEHLRSVLADEHSVEELASAVLAALPAEFTVSDLDRVLAHVHPELLTRLGARSTVDALRRVITSTYDTRFEAGVELAQQVLLPAAADESNGMEDARFVRFEEPDGTVEYRATYTAYDGQRIAPRLLRSPDLRSFGAHRLSGPAARNKGMALFPRTIGGRYFSLCRSDGESTSVSSSADGYRWETPQLIHPPQASWEILQVGNCGPPIETERGWLVLTHGVGAMRTYSIGAILLDLDDPTRLVGRLERPLLQPAADQREGYVPNVVYSCGGLVHDGILWLPYGVGDALISVGWTPLGDLLEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGM5</accession>
    <name>A0A010YGM5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848030.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.429"/>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_11"/>
    <dbReference type="OrthoDB" id="170130at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="156"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="337"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="441"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="777"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="874" mass="96492" checksum="AC47F12A935C08FC" modified="2014-06-11" version="1">MLTPYALSTDGRTTPLGVDERTPLLSWRLRSDRDADAQTAYRIEVTTGGVTAWDTGRVESAENSAIAYDGPTLRSRTRYDWRVTVWDGSGEEAGAAESWFETAILHADEWVGTWIARDPNVHPPFDPPVVDDLTDRVRHLPAPPHLRRSFTLPAKPVRARLHATARGVYEPRLNGAKVGDRELAPGWTEYRTRVLYQTYDVTDALTAGENVLGAVLVDGWYAGFIGFDSRHQAQHYGDAPQFLAQLHVEFADGSTRTIATDADWVERPGAIRYADQLMGQYEDGSRELTGWDAPGYDASDWTPVVIADTAPGTLVAEPDEPVRVTEELTAVSVTAIGADRHLVDFGQNMVGRVRLTVRGAEPGRRIVLRHAEVLADGELYRENLRTAEATDVYLTAGGATEVFEPRFTFHGFRYVEVTGYPGVLAGKDVVGRVLHSDTPFTGHFECDDETVNQLYRNIRWGQRGNWVSVPTDCPQRDERLGWLADAQIFAPTATRNADVQAFFARWLADVRAAATPEGAFPDIAPKVAMLTEGAPAWGDGGVIIPWLLYRIYGDVRTLERSFGSMVAWIEHVHRHNPDLIWRHRTGNNYGDWLQVDAETPRDLLATAYFAQSVALVGAAARALGVDAQPYEDLHGRIRAAFQNEFVEDDGRVEGDTQTGYLLALAFDLLPPALVDRAFHRLAADVEKRDNHLTTGFVGVALLCPVLTKHGRADLAYALLHQDTYPSWGYSIAHGATTIWERWDGWTTERGFQAAEMNSFNHYSLGSIGDWLFGGVAGIEQAPGSVGYRELELRPAVGGRLTRAGASQETIRGRVASSWRLDGDQVVVDVEIPPGSTANLHVPTSDPSSVRDRSGSPVADQLRLSSGRYRFTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH57</accession>
    <name>A0A010YH57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848362.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_9_1_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="26875" checksum="CB3A2A89728FE6C5" modified="2014-06-11" version="1">MTTAPLTRRERLRAETVEEIQSTARRMLVSDGYDGLSLRAIARAMGMSAPALYRYYASREDLIAALVDELKVELSEALEKVRDAQPDLVSKLLECSREFRRWAMTNPAEFTLVFTASAIGLDRPREDGSVDPTGERFGNVFGELITELYLTQPFPIPADDEIDGPLKDQLQEWNDCFPQPLPLGVTQVFLTSWIRLYGTVSMEVFGQLKFALSDAGPMFEAELRALGDMLGVGADYQPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI63</accession>
    <name>A0A010YI63_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1001"/>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="72"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="27044" checksum="C35160126173C7FF" modified="2014-06-11" version="1">MGRPAYLDADAPVAADAAQVRELAAGAQNLDELDAGVAHCRACDRLVEWRERVAAEKRAAFADQTYWGRPAPGFGPPDARILVLGLAPAAHGANRTGRVFTGDRSGDWLYAALHRAGLANQPTSVSVDDGLELRDVRIAAAVRCAPPANKPTPVERDTCSPWLVRELQLMAPTLTVIVALGAFAWTSFWPVVGALGGTAPRPRPRFGHGAAVAVPGTDVTMLGCYHVSQQNTFTGVLTEPMLDGIFAQAKALTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIA0</accession>
    <name>A0A010YIA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1031"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="25341" checksum="D011C12645392FF2" modified="2014-06-11" version="1">MWGMRARVLVVDDDPALAEMLGIVLRGEGFAPSFVADGEAALTVFRETRPDLVLLDLMLPGMSGLDVCRAVRAESGVPIVMLTAKSDTVDVVLGLESGADDYVVKPFKPKELVARVRARLRRGDEAPPETLTIGPPQSQVQIDVPGHSVTRDGSPIALTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRAKVERDPEHPEVVLTVRGVGYKAGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIZ2</accession>
    <name>A0A010YIZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1247"/>
    <dbReference type="HOGENOM" id="CLU_092522_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17157" checksum="41C4D2190D0BF53F" modified="2014-06-11" version="1">MDAFNDADADTAAALLHPCCASTAWAKAIVAGRPYPGLDAVIAASDPVVKGLSWADVEEALAAHPRIGDRPKVAATTEKRWSQGEQAGVADADQEVLAALADGNAAYEARFGHVYLVCASGKSAEELLGILQDRLDNDPAHEHDVVRGELAAITRLRLAKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ93</accession>
    <name>A0A010YJ93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849094.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_9_1_11"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="7134" checksum="BF9015F8831CFF30" modified="2014-06-11" version="1">MAATEWLTVDELAAELKVPKATIYKWRANREGPRAAQIGRHLRFRRGDVDAWLEAVCLETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJG0</accession>
    <name>A0A010YJG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849226.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1417"/>
    <dbReference type="HOGENOM" id="CLU_085646_0_0_11"/>
    <dbReference type="OrthoDB" id="1659475at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025450">
        <property type="entry name" value="YndJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14158">
        <property type="entry name" value="YndJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="28741" checksum="277430B60640C846" modified="2014-06-11" version="1">MRWAVVPAIALGMLVIVPVGLGLLEAPGLRTVRRWWPPVAIVGALSLAMPVSLPAVGLACVYAAGTFVLAGTAAARLRRDRSLAPVDVAALTALVTPAVAGASLVVERVGGTLLGFGPKILLLTVAHFHYAGFAAALVAGLVAQATRAGSATRAAAVAALTVPAGTLLVLIGFFAGELVELAGAAVLTAGMWVVAALSWRLRASVSDRSARVLLGVSSVVLVLTMLLALDWALGEAFGVPKLSLTWMAATHGVLNAVGFGLCAVLAFSRLSAGSDDRTRRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKB5</accession>
    <name>A0A010YKB5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849681.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1730"/>
    <dbReference type="HOGENOM" id="CLU_130902_2_1_11"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="105" mass="10965" checksum="5344468BA87EF367" modified="2014-06-11" version="1">MKYVLLIAGDETAAGHANDGCGGWDAEMLARGVLVGGAGLHPPMDATTVRVREGETLLTDGPFAESREQIGGFCLIECADLDEALEIAAKHPAATYGSIEVRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKV6</accession>
    <name>A0A010YKV6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849980.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127113_0_0_11"/>
    <dbReference type="OrthoDB" id="1950078at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="14506" checksum="EF3D72B3CB1FA88C" modified="2014-06-11" version="1">MTNASPATVLVYSDDAAVRERIRMAVGRRPAADIGPITWVEASRGDEVVRLADAGGLDLLLLDAEAWPTGGMGISRQLKHEIDDCPPVGIVLARKVDRWLATWSEADAVLSHPLDPVSAATTVADVLRTQLGVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLZ5</accession>
    <name>A0A010YLZ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maleate isomerase</fullName>
            <ecNumber evidence="1">5.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Maleate cis-trans isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">maiA</name>
        <name evidence="2" type="ORF">CryarDRAFT_2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>maleate = fumarate</text>
            <dbReference type="Rhea" id="RHEA:13169"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
            <dbReference type="EC" id="5.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the maleate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850478.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2303"/>
    <dbReference type="HOGENOM" id="CLU_068086_0_0_11"/>
    <dbReference type="OrthoDB" id="1739382at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050076">
        <property type="term" value="F:maleate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00943">
        <property type="entry name" value="Maleate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028615">
        <property type="entry name" value="Maleate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="S-(2-succinyl)cysteine" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26088" checksum="C14AEBF3543C7D47" modified="2014-06-11" version="1">MKHVRVGLVVPSSNVTVETEMPAVLSRHPAATFSFHASRMRMARVSPEGLAAMNAQRERCVLELGDAGTDVLLYACLVALMAAGTGEHQRVEGLVAEQLATGGADTLVRSSAGALTEGLRALGARRIALVTPYLRSLAEKVVRYLEAEGFEVADWRALEVEDNVAVGCIPGDRVMDAARSLDLTGVDALVISACVQMPSLGLIDAAEKEFGLPVLSAATAGAYSILRATDLPVAISGAGSLLRADVPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMA7</accession>
    <name>A0A010YMA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase alpha chain</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2424"/>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="113"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="113"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="22990" checksum="ECB851807E63FF55" modified="2014-06-11" version="1">MSALRSLLEARRRTAHMFTGIVEELGTLAAVEELDRAARLRLKGPRVAVDATYGDSIAVNGVCLTVVENTGDEFTADVMAETLTRSALGGLVPGDPVNLERAATLSTRLGGHLVQGHVDGVGTVLERRPDTHWEVVRIGLPPELGRYVVEKGSIAVDGVSLTVTAVADDWFEVSLIPTTLSATTLGGREPGSRVNLEVDVVAKYVEKLLPGPKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMB1</accession>
    <name>A0A010YMB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110740_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17470" checksum="888F60FECA1D1F4D" modified="2014-06-11" version="1">MTVTSPEADVVRSRPHRLTIVCWILAIAVIVIFSVVAVLLGRPTTTVDPEVGPPFGLGDQIGMVFLGVLLAGGVLSLTRPRIVADAEQVTVRNVVGGVTVPWTLVRGVRFDRHSPWAALELLNDELVSVLAVQAADKHRAVDAVRGLRRLHAAAWEGKEPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMS4</accession>
    <name>A0A010YMS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850872.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2600"/>
    <dbReference type="HOGENOM" id="CLU_140987_1_0_11"/>
    <dbReference type="OrthoDB" id="1629665at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="103" mass="11165" checksum="D34F7456B5FFC1BB" modified="2014-06-11" version="1">MSEPRSNFVARAVEWLRAGYPSGVPRQDYVALLGLLRRKLTEHEVRSIADDLALLALQGEEITTADVEKLINEATLDQASEEDVARVSAHLAAGGWPLADAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMU1</accession>
    <name>A0A010YMU1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="12">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysC</name>
        <name evidence="14" type="ORF">CryarDRAFT_2651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">APS kinase catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="12"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570102.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2615"/>
    <dbReference type="HOGENOM" id="CLU_007265_5_3_11"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="441"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="619" mass="66757" checksum="9C16F837CAC5B43E" modified="2014-06-11" version="1">MKSLRVATAGSVDDGKSTLVGRLLYDSKATFTDQLAAVEQASRDRGEELNLALLTDGLRAEREQGITIDVAYRYFATPKRSFVIADTPGHIQYTRNMVTGASTADLALILVDAVNGLTEQSRRHAFLASLLGVPHVVLCVNKMDLVGWSAARFEEISADFTNFAARLEVPDLSVVPVSALLGDNVVHRGANMPWYEGLPLLHHLEQVHVASDRNLIDARFPVQYVVRSPGFRGYAGTLGGGVLRPGDEVVALPGGFTTTVRALWGPGGVRLDEAFAPQAVTVQLADEIDVGRGDLLCRPGNRPHVGTDLDALVCWFSERGALDVGGRYVLRHTTRETRARVGTLEYRLDVNTLHRDPDATELRLNQIGRVRLHTQTPLSYDPYRRNRATGGFILVDEVTNETVAAGMITGPAVASSSVRWHSSGVTRDDRATRGGTVWLTGLPASGKSSVAVELERRLVAAGRPAYLLDGDNLRHGLSADLGFSREDRAENVRRVGEVAKLFADSGAIAVVSLVSPYRADRDAVRAAHREAGLPFHEVFVDTPVEVCASRDPKGLYARGEPGLTGVDAPYEAPFTPEAVLRPGDGDPATMAAAIADLLENQRLQAGEGAADQRGSHHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNF5</accession>
    <name>A0A010YNF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851137.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2786"/>
    <dbReference type="HOGENOM" id="CLU_037990_10_3_11"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="rADc" evidence="4">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="20407" checksum="11BD58A571B37FFF" modified="2014-06-11" version="1">MPMNWFHRRLCSSDTWFAKVEETLLPWALKGVDLGADVLEIGPGFGATTRVLARSVPRLTAVEVDPASAARLRTAVPGVRVVTADATALDFPDDSFDAVVCFTMLHHVPSPAAQDRLFASAHRVLRPGGVFAGSDSRTSARFRFLHVFDTMVVVDPDVLPERLRTAGFSDPLVTTVPGSFKFRARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNJ7</accession>
    <name>A0A010YNJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851164.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2822"/>
    <dbReference type="HOGENOM" id="CLU_017028_9_0_11"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458817" evidence="2">
        <location>
            <begin position="28"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="110"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="582" mass="63711" checksum="3DF90AD06E8040D0" modified="2014-06-11" version="1">MRSAKLVTVGVLAVALAAAGCTKNTGSDNNDDNNNQEAATQSATLAENSDGPAPDVPGAKPGGTVTIYTSGDFEHLDPQQNYVVPSQTVGSNLLYRSLLQYRENGDGKLELVGDLTTNTGEESNGGKTWKFTLKDGLKYEDGTPITANDVAYGIARSFSPDLPNGPHYIQQWLVGSGDYNAKYKGPYDGGAKIPPGVEVPDAKTIVFNFPTPHADAPFAMALPTTTPVPPSKDTKVQYDNRPFSSGPYKIQEYRRGQQMTLVRNTNWDAKTDPIRHQFPEKYVVDFTRTAEQASELLLADGGAAQTGLSFQDLQIPASVYPKVIANADAKKRILTGTTQFVWMFDFNLQRMKDINVRKAFNYALDREGLLKVWGSYSGDPATTILSPTTSGYEQYNQYDGGKNGDPAKAKELLGNKRVPLTYAYRNTERNQAVAAFLRSSMKEAGFDLTIQPVDEDQYYTVLGAKDNQFDVYMQGWGSDWPGGAAIIPPLFDGRAITPTGNQNITYLNDDQVNKEMDEILALSDLTEASKRWAKLDKDMMTRIVPIAPAIYDKQTTMYGSKIGGIYLSAPYGNSGLNNLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNR7</accession>
    <name>A0A010YNR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851256.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2892"/>
    <dbReference type="HOGENOM" id="CLU_043966_3_1_11"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="18961" checksum="6C8751A3304EF0AF" modified="2014-06-11" version="1">MGKLLYGATMSLDGFIAGPGDDMQWLRDFLGPDPVADELVAQVGSCLVGGRSYRGDDPNMGTEKEGPFGGAWEGPQFVLTHNPPDVAVPGITFVTDLATAVTASKAAAGDKYACIIGADVGRQCLEAGAVDDVLMFVAPILLGDGVPMFRHLGGAHIRLNPPRVHRTDHAVSLWYTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNW4</accession>
    <name>A0A010YNW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">CryarDRAFT_2986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851321.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2946"/>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_11"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="14"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="27478" checksum="C695F45A70634607" modified="2014-06-11" version="1">MIEILNLTDLPRARAAGALVANILQTMRSRSEVGTNLLDIDRWTQDMITGAGAESCYVDYEPSFGRGPFGHYICTSVNDAVLHGKPHDYTLADGDLLTLDLAVNLGGIVTDSAISFVVGEKRAPEDLALIDATERALSAGIAAARPGARIGDLSAAIGAVLNAAGYSINTEFGGHGVGSTMHQDPHISNTGRAGRGYKLRPGLLLALEPWVMADTDKLVTDDDGWTLRSVTGCRTAHSEHTIAITEEGAEILTRVGERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPI5</accession>
    <name>A0A010YPI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851684.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_11"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="31784" checksum="B287FDAEB4D9A0BB" modified="2014-06-11" version="1">MADRFTTTRIDVGDVELRVRYGGDGPPLLLLHGYPETHELWNPIADALAEGFTVVAPDLRGYGESSAPATVADHSTYGKRAMARDAIALMRHLGFETFDVAGHDRGGRVGYRLALDRPAAVRRLTVLDIVPTGEVWARADDRFALGYWHWAVLAQPYPLPETLIAADPEWFFFDAQFGGAMRTFPAVGEYARHVRDPRVVHAICEDYRAGATCDRADDDADRAAGNRISCPVQVLWAGSGAVGTWYDPLAVWRNWADDVTGEAIESGHFIPEQNPAATLAALRRFHGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQD5</accession>
    <name>A0A010YQD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570498.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2536936_0_0_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="83" mass="8993" checksum="C44848FA537A1C55" modified="2014-06-11" version="1">MSAIHHVGLTVSDLERSTDFYADLLGGDRLGPFERSVRALSEPIVASAPLAGHRCVYVLDPDRIRVELVEPPHESAADPSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQV4</accession>
    <name>A0A010YQV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852479.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3745"/>
    <dbReference type="HOGENOM" id="CLU_131496_11_1_11"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="12032" checksum="CC79FDB4EDC7BADA" modified="2014-06-11" version="1">MTATPNGYVTVIWQTRAKPGRETDLKDFISAAVTPSRNDPGNIDYEAHEVEGQPGSFVIYERWESREHLDAHLGAPRMADLVPRMLELIDGSIEDGITLLRPFRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR86</accession>
    <name>A0A010YR86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid-responsive transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3874"/>
    <dbReference type="HOGENOM" id="CLU_067515_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="196"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="35764" checksum="C541FAC6236236E9" modified="2014-06-11" version="1">MTAEEIDGGFRLPRAQGGPNPQHLFVTLFGDYWWARSEHLPSAGLVALAEEFGISAASARAALSRLRRRNLLSASKVGRHTYYGLAPTTRQTIVEGGARILSFGTDDQAEWDGTWLVVAFSIPEDQRDVRHTLRTRLRWLGFACLYDGVWVSAGGDASGADAKAVVRECGIRDASVFRATSLDAVGEDAGRHPLSAWDLDHLSAVYQDFIDRFEPLYQRILDGDIRSSEALVERTAVMDVWRSFPGLDPGLPSQVLPSGWPRHRAREVFSSVYDSLGPLAQVRFQHILSRYAPGLAPLVDHHLTTSGPMVPELAADLTGQVGHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRI7</accession>
    <name>A0A010YRI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035865088.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3980"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16963" checksum="52C6BCBDE9C0F93E" modified="2014-06-11" version="1">MTVDDIDQELLRLLSADGRRTFSEMAGEVGLSVAAVKRRVDRLREIGVITGFTVKVDHTKLGWGIEAFTELRYAGATPVSAIITSAFAVPEVQAVYAIAGDPDALVHLRVRDIRHLQQAIDRMRRTGPVVGTKTLMVLGSWNRDDPAPGPVSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV75</accession>
    <name>A0A010YV75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class putative F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847462.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.71"/>
    <dbReference type="HOGENOM" id="CLU_123922_0_0_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="17696" checksum="E9C658DC68A32086" modified="2014-06-11" version="1">MPNYATADAVDRDALLEFLRPRHHGMLATTRKDGRPQLSPVTCGVDAEDRIVVSTYPDRAKAFNARRDTRASICVMSSDWDGPYVQVDGSIEVLDLPEALEPLVDYYRCISGEHPDWDGYRAAMQRQGKSLLRITIERWGPIATGGFPPRLAEQFGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVU4</accession>
    <name>A0A010YVU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847767.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.261"/>
    <dbReference type="HOGENOM" id="CLU_104845_0_1_11"/>
    <dbReference type="OrthoDB" id="1956412at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="152" mass="15209" checksum="9C3CDE254C84F371" modified="2014-06-11" version="1">MSKIAERLAELGLTLPTVPAPVAAYVPAVRTGSYVYTSGQLPIVEGKLGVTGLVGGEVSAETGYDLARIAGLNALAAVASVADLDDVVRVVKAVGFVASAPGFTGQPGVVNGASELFGAVFGDAGKHARSAVGVAVLPLNAPVEVELIVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW59</accession>
    <name>A0A010YW59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847981.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.397"/>
    <dbReference type="HOGENOM" id="CLU_033716_2_0_11"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="411" mass="45594" checksum="93D2CCF27376A25D" modified="2014-06-11" version="1">MTGSLASAPAFDPWSPEFVAWPYDVFADLRENAPVWRFERTGQWVISRHADVDALLRDRRLGRSYLHVATHEEMGHEPPADHLEPFWTLNNNGMLDREPPDHTRLRRLVSKAFTPRTVERLAPWVRSYTEGLVSQLLDAGSDGSPVDLIQTVAEPLPVAVIAEMLGIPEADRHLLRPWSADICGMYELRPSAQAQDKAVRASIEFTDYLVALAAERRQNPGDDLISALATVVDAGDQLTDPELVGTCVLLLNAGHEATVNVTGNGWWALFRNPSELARLRDGEVGVGSAIEELMRWDTPLQLFERWVLEDIEVHGVRIPRGDEVALLFGSANRDSAVFPDASRLDLGRTPNPHISFSAGIHYCLGAPLARLELGTSFETMLRRVPGLSLAEEPRWKGGFVIRGLDALQVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWP5</accession>
    <name>A0A010YWP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.606"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="681" mass="70551" checksum="83F6C545904AA7D2" modified="2014-06-11" version="1">MADTQQTVLAGRYRLVDQLGRGGMGTVWRAHDELLDRDVAVKEVLLPPGVDDETRDDLMERTKREARAAARLSHPNVVTVFDVVEVEGRPWIVMELVKARGLNQIVRDEGSLVPERVAEIGVQLLNALGVAHASGIFHRDVKPSNVLVSDNGRVVLADFGIASVQGDPAMTRSGLILGSPSYIAPERARGLPAGPASDLWAVGATLYTAVEGRPPYDRDGIVPILTAAAMEDPDPFVKAGPIAPVLTALLQREPSKRPSVEEARLALRQISLAALPPAPERPRRRNLSATAVLPATDPVQEKPAKGAGAAKPVSPAKPVSPAQPVSPAPRPVSPAAAGAAAAGTAAADATAPTPAPVEPASPAEPTSPAPSGAGTEDASAVEAVAPASPAAATPAQRTPIEDAPAAEAESVSPAPVGFASEPGTKTPRRAAFPPDDDTPAPTTYGSSPSGRGRLIGVIAAVLVVAVVVAGLVYALADRSSDDNTADPSPSAAASSSSAGAPSATQSAGPSGGSPSASAPPASPSASAGTGSSPIPAGWRKVTGPGGFTIGVPNGWSASDSGDGYRINGNNGFFLLIQQSKQPKPNAKQDWETQESARRARLSNYQRISIEEIQYRNYTTAADWQFYFNRGGQRIHVVNRGFVTSPSQAYGMYFEAPADEWDEGYNTYFQVFANTFQPAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY67</accession>
    <name>A0A010YY67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1199"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_32_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="42786" checksum="96849C153A1FADFF" modified="2014-06-11" version="1">MTIVDEDRIWFKATYGVDVTEIGRDPGLCASAILADEPVAIEDTALDPVARDNPLVRGDLAVRFYAAAPITTSDGYHLGTVNVLGPEPRSTTPEELQTLSDLAAIVVDELELRLSALREVRLERRRREEVQKSKAQVEEVARTLQQTLLPPRMPQVPGMELSAFYHAAPLQEVGGDFYDVFPLGGRRWAISIGDVSGKGVQAAALTSLARYALRGAAIQTSDPSLVMAALNETIVADQAAQDVPRYCTAVFCVVEQTESGSAQVRLANGGHPPAVVCRADGSIERLTDSGPMLGWLPDSRYPTLEALLGPGDGLLFYTDGITDARRYGQRFGEGRLAAALADRPHNNAKSLVRWVRNLMNEFDPPGYDDVAVISISVEPIHVTERQLTGVWAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYJ5</accession>
    <name>A0A010YYJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849090.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1314"/>
    <dbReference type="HOGENOM" id="CLU_1710210_0_0_11"/>
    <dbReference type="OrthoDB" id="1902876at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="17914" checksum="4118EF2293908F60" modified="2014-06-11" version="1">MPVPALIPIAREPGYRTDTIGRFAEGQFYAVIHGAHRDDDEELDLRRERIRWYAYLHRFDHAGNHVRSEISLIGVAPYVRGEFRRRAEQRLRELLDDLVDRDYGDIAIRPFRVLYDGVTFGLIDESDAERDAWAELYPDRLGFTEPWDGTYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZL4</accession>
    <name>A0A010YZL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116759_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458908" evidence="2">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="19748" checksum="F3A29F231494A24D" modified="2014-06-11" version="1">MLYARSRRVPMALGAAAAGTFLSWLIASTTSDQDPVGSTALLLAVLLLIAIATATLGGPDASLDRTAARPWARLRASHLIVVLGCVTLLLQATEVTGTRFGPIGFVVRNAGGLLGLTALGAAAVGAARAWILPLGWTLLAATFPGHGRVGEALTWQIQSPGSRPATVVAAVLGLAGLVAYTLRGPRPGTSPENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z026</accession>
    <name>A0A010Z026_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1879</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849868.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1846"/>
    <dbReference type="HOGENOM" id="CLU_009154_2_0_11"/>
    <dbReference type="OrthoDB" id="49937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="153"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="497"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="913" mass="102003" checksum="83E4AC62E5E23B3B" modified="2014-06-11" version="1">MANSRERLPVISDGLPSQLPDIDPGETSEWLESLDAVIDNAGRQRARYIMLRLLERAREKQVGVPALRSTDYINTIPPEREPWFPGDEHIERRLRAYMRWNAAIMVHRAQRPGIGVGGHISTYASSASLYEVGFNHFFRGHDDPGGGDQIYFQGHASPGMYARAFLEGRLNEHQMDGFRQEFSHSGGGLSSYPHPRLMPDFWEFPTVSMGLGPINAIYQARFNRYLHSRGIKDTSQQHVWAFLGDGEMDEVESLGAIGVAAREELDNLTFVINCNLQRLDGPVRGNGKVMQELEAFFRGAGWNVIKVVWGREWDPLLAADTDGALVNLMNTTPDGDYQTYKAESGAFVREHFFGRDPRTRKMVEHLSDDEIWNLKRGGHDYRKLYAAYKSATEHTGQPTVILAKTIKGWTLGSHFEARNATHQMKKLTEDDLKEFRDRLFLEIPDEKLDKYLPPYYHPGKDSDEYQYLMERRRQLGGAIPKRVDRSKPLALPGKEMYAQLKKGSGKQKIATTMAFVRLLKDLMKDKNIGDRFVPIIPDEARTFGMDSLFPTAKIYSPHGQQYTSVDRELMLAYKESQQGQILHEGINEAGSVASFTAVATSYATQGEPMIPIYIFYSMFGFQRTGDGFWAVADQLGRGFVLGATAGRTTLNGEGLQHEDGHSLLLASTNPAVVAYDPAYAYEVAVITEDGLRRMYGENPENIFYYFTVYNEPMVMPAMPDHVDEEGILRGLYRYAPATLTTEGAPKAQLLASGVALPWALKAQQLLAEDWNVAADVWSVTSWTELRRDAVEAEEEALLHPDGEARTPWVTAQLAEAQGPVVASSDWMRAVPDQISRWVPGDYTSLGTDGFGASDTRHALRRHFKVDAESIAVATLRALAKRGEIEASVASDALAKYRIDDVTAAPPGETGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z052</accession>
    <name>A0A010Z052_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849921.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2394781_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="93" mass="10330" checksum="B5DC89C2903F1E15" modified="2014-06-11" version="1">MSAHDPCFDPPSRPGAAAGGTSPWRVWPLGRNRWLLLREDDPIAELGVLGTAEWWVRPIGDDLPWAETYGGRSAASRAVIVWWLHTHPFGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z060</accession>
    <name>A0A010Z060_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1896"/>
    <dbReference type="HOGENOM" id="CLU_1364293_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="19463" checksum="B640CEA61C93B59C" modified="2014-06-11" version="1">MRPVVKQSLTARNMPVDAQRGDAATGLPFGAMDATPRLRVGEVVAVFAPLAEALAPGERAGQLAVLAVRSLLGLPAAPPTDRRAGPGPGFTAGLGSVAAAAGPGLGFAAAGLGSVAAAGTGSGPTAGPEPGFGAGPESGFSAGPEPGLPVGWPERLVAYGVPAGLVAVLAAAVAERIPTAREVAAALRETCDPIPIQLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0K2</accession>
    <name>A0A010Z0K2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850129.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2043"/>
    <dbReference type="HOGENOM" id="CLU_080373_2_0_11"/>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="14040" checksum="60F18BBE92AB289F" modified="2014-06-11" version="1">MTYPPPGAARARYLADSISTASPARLLVMLYDRLVQDIAQGEQAIREGNRLLAGERLMHAQDIISELLATLDLTAWDGAENVAALYRWMLSELVQANIKQDAGKAASTLELANELRDAWREAAMAVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0P4</accession>
    <name>A0A010Z0P4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2087"/>
    <dbReference type="HOGENOM" id="CLU_609316_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="208"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="449" mass="47451" checksum="1B39CC0FE5D35FB6" modified="2014-06-11" version="1">MTGPKRHKRPPNQFRRRSLIIMAVVTTMVVALGVGTASAGLRGDRQNYGWKKAGQNWGHGHGKPTQSGNPQASSTADPANSENPDDEGDGQGDGNGDGQGNGNGDGQGNGDGQGNGDGQGNGDGQGEGDGQGEGNENGGGQNGEEPAEGDGEETAAPARGPVPEDFINIRQVRPNQQAAPRGNRNGSRGSFRVNCSINPNGFNSDNVIVAPGVDNGAHHLHEYAGNTTTSGKSTDESLAAGGTTCTNGDKSTYYWPVVRDITKDTPQRFTNELEEDLNEGAPLTPKFTIQYKGNPTQKVVAMPKFLRIITGDAKAFTNGGANANAHFTCTGFTNRITTDKYPLCPGGRGLQRTFAFQNCWDGVNADSANHRSHVAFSDPRTGACPSGFKAIPQLTMTLTYNVPAGPNFAVDGFPEQLHKPINDHDDFINVMDEGLMNRVVQCINSGRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z109</accession>
    <name>A0A010Z109_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850309.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2191"/>
    <dbReference type="HOGENOM" id="CLU_038683_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458225" evidence="6">
        <location>
            <begin position="27"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="40483" checksum="826EBA36F228EE70" modified="2014-06-11" version="1">MRSTRHTLGFWLVAATLFMIMVAASAPSPLYVVYQARWHFSTLMLTVVFAVYVGALLAALITVGRLSDHLGRRPVLLASLVVEAVGMAVFLSADGLGGLVLARVIQGLATGAATGTISAALVDLLPPGRARLGAILNSAAPLTGLAFGALASGLLVQYVSAPETVVFAGLTIAFVLLAVLVVALPETIERRPGALTALRPRLGVPREARATFVATSPVLLATWAMGGLYLSLGASLTSGVLGVENHVVAGLVVSVLAGAGAVAGVVASDRAPARVMTVGAALLAIGTIGSLIALVDGSTVGFFAGSAVAGLGFGSGFLGALRSLAPLAAPAERGGLFGAIYTVSYLGFSVPAVIAGVLVPRVGLRETAVGYGLVVIALALSVVVPRVFRIRRPVRATPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3K2</accession>
    <name>A0A010Z3K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative amidoligase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063443_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="39716" checksum="3B45D6B179B1D3EB" modified="2014-06-11" version="1">MTSALCANCPADITTQDGALRCRACIGHAHSRCDGCGQWYLATAYCSDCFYCVSCDRAVPSDATSTLASGEEICSDCRSRFYWCCEECGEYTSDDTDSCDNGCPTRCGCDGCSDERSLIFDYSYKPLPIFHGAGPLYLGLELEVHSIDDHGPARTATSHLGDLGYLKLDNSVTDGFEIVSHPMSYTWALAHFPWEMLTLLREHGCRTSERTGLHVHLSRKGFSSPGHTYRWMKLLYRNEQQIVRLARRSSPDFAAFTNRDRRAVKDYAKGTSGNVRYTAINACNTDTFELRVFASSLDAEEVRAALALADASVEYTRHLTVPVITRGGWTWAAFAEWVAARPQYGPLSAQMETHACAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3P6</accession>
    <name>A0A010Z3P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3288268_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="40" mass="4600" checksum="31D91F3834387996" modified="2014-06-11" version="1">MLRIERFRIKKNSCNVKANSPIYGRRAGYPFGRQESVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4M6</accession>
    <name>A0A010Z4M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_3464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570426.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3425"/>
    <dbReference type="HOGENOM" id="CLU_006313_3_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="339"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="631" mass="66893" checksum="C9D4269CDBA0D4AC" modified="2014-06-11" version="1">MRSLSKGGILAVLAVVAVVLPYTVGRYTIHVIDVTIIFAILAIGMGLAMGISGQINLAQIAFFGLGSYVTAILTVREGWGFWTASVLAVLATVAVGLLVGTPALRVQSHYLGIVTLGLALAFTNWLTNTELTGGAEGISGIPVPSLPGVDLSSEYLYYYLEILAFAVLLTFGQFVVRTPLGRRLRAMRDDPLAAGAMGAEVPMLRMTAFALSSVYGGLAGVLYAGLIRYVAPETFSIANMFLLLAMVIIGGRQSLVGCVVGAVGLSLVREWLVDYPTYAQIAYGSVVVLTVLFAPTGLAGLPERVRGAYRRRRPAAADRAVLRPFQPYGDAGERAGSALEIAGLSKNFRGLKALDDVSLSVPAGQIRGIVGPNGSGKTTLFNVVSGFYKPSRGSVRVGGRTLTNASSHRLAQAGVARTFQNLRLFPAMTVRENVLVALDQTRTRSIWRYAVWQLGVWRHDRALRSSANAVLERYGLVDFADSLPGALPYGIQRRVEIARAMARSPRLLLLDEPAAGLNGDEVRQLGEIVRSIRDSGVTVVLIEHNMGLVMSLCEHVTVLAGGRVIADGTPDEVATAPQVIEAYLGDSMDDVLPAEASSGPAPEAATDPAPEAATDPAPEAATDPAVKEIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z578</accession>
    <name>A0A010Z578_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852341.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3659"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="279"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="537" mass="55343" checksum="8AABEE6FC5D22557" modified="2014-06-11" version="1">MNGSAPQSGSKRRSPAGRFFDLPVRTKLGALVGASLVALATCLVVTTVSHQIADSTATRLQNINEAGALVLQLDRQATELKSSALQALVRSDPATQQALLADQVGAADQLLGRLETVDLPRSLSSAVSRIKTAYTDYTAVVTRFVAGAAVDPAGARSAWGQIGIDNYLTSTVLENERTLFARVVTAEEAASATSRRNAQYVLWATAAATALLLCLLARFVVLSITGPLQRVRLALAAMAGGDLTVRAEISSRDEVGQMAHALDEAQSGVRSVIAAVSDSAFHVAAAAEQMSSTSSRIEASAQDASGQAQGAAEAAAQVSDNVQTVARGTEEMGLSIREIAHNATEAARVASQAVGVAQTTTEQIGKLGQSSTEIATVVKVITSIAAQTNLLALNATIEAARAGEAGKGFAVVASEVKDLAQETARATEDIAQRVDAIQSDTEAAIAAIGQISEVVMQINDFQSTIAGAVEEQTATTSEMNRSVSAAADGAGGIATNIAGLATATQITTEGISQSQSAVAELTRMAQQLQALTTHFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5C1</accession>
    <name>A0A010Z5C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3700"/>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_11"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="22914" checksum="3BBA7E7450247882" modified="2014-06-11" version="1">MSGPLGRDEMARVLARDIPRGAYVNLGIGQPTTVADHLPPESGVVLHTENGMLGMGPAATGDAIDPDLINAGKFPVTELPGAAYFHHADSFAMMRGGHLDLCVLGAYQVSASGDLANWHTGEPDAIPAVGGAMDLAVGAKRVFVLMSLFTRGGEPKLVRDCTYPLTALRCVNRIYTDVATFEITGDHVLVRETWGISFSELRSRLDVPLERHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z623</accession>
    <name>A0A010Z623_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852674.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3914"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="24948" checksum="1C910D1905EDFE61" modified="2014-06-11" version="1">MLEVTGLTAWYGQAQALHGVDLRVDEGEVVTLAGRNGAGKTTLLRCLIGLHRQAGGRVSFRGRDLARVPAHRRARAGLGWVPDDRGIYAGLTVEENLLLPPTVSDRAWPLERVYEVFPVLAERRRAPGTTLSGGEQQMLAIARVLRTGARLLLLDEPSEGLAPVIVARIGAIIREIKATGAGVLLVEQNVTFAATVADRHYLLGQGRVVDTLDNSEFSRREGELLKHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z693</accession>
    <name>A0A010Z693_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852776.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_2_1_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21518" checksum="2DCEEACFD998AAF7" modified="2014-06-11" version="1">MKLNRELIVDAGMRAFAERGYVGLSMRQIADALGVHAGSLYYHVKNKEQLLALLADRVAGEAYDAGTAALGALSPAASWEERIEAQLVALRASLLARTGAPALLAASPAVLSPAALALMERLLRTLDAAGVAPDTRPVAADTLLSYVTGFVLQEQAPPADVQPPADLAERYPMTVAGAGSDPDTLFRTSIRLLCAGIATDRTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL39</accession>
    <name>A0A010ZL39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847948.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.378"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_11"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="33232" checksum="E3CC6284429EC0E9" modified="2014-06-11" version="1">MRAIRITSFGGPEVLVPAELPDPVASGNAQLLDVSRAGVNYADTHQAENSYLAASSLPMVPGAEVVGRLADGRRIVSLLAGGGGYAEKALVEPGLSFDVPEGIDDTTALAMVVQGASAWLLLRRSAVLNPGESVVVHAAAGGVGSLAVQLAKAWGAGRVIATASSDEKRELARELGADVAIDSRSEDMTAALREANGGQRVDVVLDMTGGRVTDQSLRALAPFGRLAFYGMASREQPSPIELRNLLGHSTTVAGMWLAHAFLLPGDVLRPAIAELFEMVAKGTLRAVPGGEFALSEARKAHEALRSRSTVGKLVLDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLA8</accession>
    <name>A0A010ZLA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore synthetase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.469"/>
    <dbReference type="HOGENOM" id="CLU_018283_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="149"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="409"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="585" mass="62234" checksum="EA39E357066B13EA" modified="2014-06-11" version="1">MTEPDILNRLLGAASDRSRTTGTPRTGAPTVDGVANALAVQALLRCWVREQHVAVPASGGRLDIPLAVSGVRLVADVRYRSVTGWHRFARVRFATGSPVDATLLAALLATEARGSSADLVEQVIDSTRRLDRYLRARAATPDDDPIAPFLVAEQALVAGHPLHPTPKSRPGLSDVDELGAAPELRGAAPLHWFAVDRELVRHGSATAVSALDQLAALAPRGVHAPPGTALVPAHFRQAAALLARADVQDLIADRRLHDLGPAGARWAATSSLRTLFRADAERMLKFSLGVRITNSRREHLVPELIRGAEMYRLVDAGLGALLAAAYPRFRILGDPAWAAVPLPTEDPNGQVALAVSLRDNPFGPDTRVACVAGLVAERPDLADSRSGLAVLIEDLAISTGRPVAAVAVEWLRRFVDEVIAPVAWLHGVHGLGLEAHQQNTLVTLDPAGWPVGGWYRDNQGYYLSPSRAGTLHAMLPGLGRHSEATNPDDVIDERVSYYVGVNNLLGLVGAIGSSGLADEAAVLRAAAAALGPHRFGFVNTLLDEPELPCKANLLTRVAGLDELVGPVETQSVYVRIPNPLREVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLH7</accession>
    <name>A0A010ZLH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848247.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631110_0_0_11"/>
    <dbReference type="OrthoDB" id="1220142at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459093" evidence="2">
        <location>
            <begin position="37"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="439" mass="46409" checksum="54F7548E0BD0BA9F" modified="2014-06-11" version="1">MRFLRTLVALAVTVCVALLAVAIAGYGSSQNMDGDAKAPAEVFEPFGWQASVPKSAPGPATVLVSGDGWGLQGPVYDKVAVVAESGVYRVLRYKVDVEAGENVLLSPDGSMVADAEPHQIVGPSGSPTTPPKSSEPEVWVTDLTTGRSTRSTVPGNGTARPIAWSPDGRKLLVQVGSAPEHGPWVGGDLNLLDLESGDVRRLAGLGSRLVHRAHLAAFSPDGRKVAAQVGDDLQVIDLVNRTTRTLTRLGTDRRLAGIGAWNPGGDRIAVLTLSGCTRLCTRAALGDRTWQIDEIDANSGSSSGGGFDRLTGSAVRVLGRTDDGELAVVRYRPSDDLSSDTNGVLSVDGDEVDETDYAAVEDVELLGLDASGDRRTLIDLPPGSRHVDVAADLVAADRFDGRSSRPMPFPAPFWVTALVILLLVLVLWFALKVRRRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM27</accession>
    <name>A0A010ZM27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ring-cleavage extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848486.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.745"/>
    <dbReference type="HOGENOM" id="CLU_684817_0_0_11"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="247"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="405" mass="46308" checksum="B577CD58F4079D2D" modified="2014-06-11" version="1">MIRHVVAFKFKPETSAETVAAVLAEVESFPSRYPQMRSFVLGPNISLRDTRMSHVFTIEFDDEDDLKSYLNSESHETFVRETWRPVIDSQTIVTLAASSPFRSESVLPENNRPRGPYGIQFARLATPALDEAVEFYTYLVGLQVEARTAEYAQLRAGTEHHSIELVSDPSLTQFQPLAIGLSVESEAVLDDLEKRLRAEGAEILPLHERTASIVTRGFATKDPNGLTLEFGYEFLEYAEPPMLEYRPLDLVHPFLSTDKYEESLHFYLNVLGFQASDYVMTPGRGTSAFIRSEDRYHHSVALRRDNTFFLAHLCFRMKSLDHVMRGRAKALYKNVEIASDIVNHSASTSIAFYLYDERFGPRIELCDGHRVFTPEEHETHKARRMGGDPRNIDVWRAAADDWERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN48</accession>
    <name>A0A010ZN48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.19" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569800.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1159"/>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_11"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043799">
        <property type="term" value="F:glycine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="5"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="36729" checksum="D38D444C1E3B2177" modified="2014-06-11" version="1">MSGTRVAVVGGGVIGLSCAWALARDGARVTVFEPDQSRGASLIGAGMLAPITEAHPTEPVLLAAGRAAVAAWPEFAEALAATGVDPGYRTTGTLVVGYTADDVVALDDLADRLSGLGIDVERLTGSAARRLEPALAPGVRGGLDVPGDHSVDNRALLRALRTATDAAGVTHVPAGFPAEFPAGGHPDVTVVAAGPWTPELVPELDGLVRPVRGENLRLTARRSTPVLTRTVRALVDGRGVYLVPRATGELVVGATQDEVGFDRTVTAGGVHRLLTDARRVLPAIDEYALAETSAGLRPMSPDGAPVIGHVTGDTIVATGHGRNGILLAPLTATLVARLVAGAAPANPFAPTRFSASRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNH7</accession>
    <name>A0A010ZNH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase, CocE/NonD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849047.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1283"/>
    <dbReference type="HOGENOM" id="CLU_015590_5_2_11"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="288"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="516" mass="55857" checksum="20043981E88EB040" modified="2014-06-11" version="1">MRNVLIDRLLRLPGKTRRFRVERNLRIPMSDGVELLADRYAPEVGGPAPVVLVRTPYGRGRQLALFYGAPFAARGLQVVVQGVRGTSGSGGLFEPFHHEKDDGLATLSWLREQPWCDGRVAMMGSSYLGFTQWALAPYADPPLAALCPAITASEFTSSTYLGGGVGLRGAYEWGMGVAQPGRFRGRRNRRAMSRLPLASIGTVSSYWQEVVAHDDPGDDFWAPVDHSAGVSSVTAPVSMYTVWWDIFLLNQLRDVVAQQKAGHSPRLTIGPGAHAELRGALAASRDAFEHLSTVLLGAPAPERAPVRLWLQNGDRWLDAERWPPPSAPVTWHFGSGQLAADPVDQAPQVTFYDPADPTPTVGGPVIGRDAGAADNRAVEARADVLSYTSAPLKSDLDLVGELSAMVRVRSEPGHADVFVRLCDVEPSGRSMSISDGFVRLRPGSPLEVPVEMRPTAYRVRAGHRLRMSVAGGAYPRFARNLGTGEPAATATRMVKARRETFGGSVTLPVYQQARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNS1</accession>
    <name>A0A010ZNS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849157.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1369"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="97"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="35594" checksum="8DAA2C723D778CE5" modified="2014-06-11" version="1">MDFVDWGPKLFNALLAVAVFGAVVGLLLLVVDRAPKRGHDRYQLAVFLLPAVVLLAVGLLIPAVRTTILSFTNAAGDFVGLDNYKWLFTEDEALITIRNTIIWTVLTPILATGIGLLYAIVIDKARTEAISKTLVFMPMAISFVGAGIIWKFMYAYRGGGNEQIGLINQFIVWFGGEPKQLLLDPPLNTFLLLIVMVWIQAGFAMVVLSAAIKGIPADIVEAARIDGVNPWSMFWQVTLPSIRGAVIVVLSTITIAVLKVFDIVRTMTGGNFDTSVIANEMYTQAFRFREPGRGAALALLLFVLVIPLVLYQIRVLRQREETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNU7</accession>
    <name>A0A010ZNU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849196.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="25911" checksum="3823F772BA357C9C" modified="2014-06-11" version="1">MILVTGATGTIGSALVEVLTAAGEPFRTMSRRPSAGVRGDYADADSLRAAVKDVDAVFLLTPPGPSAPAQDLALLEAAAGVRRIVKLSAFGVDEGLAPWHEPGEEAVRSGDREWTILRPSMFASNVRWWQPSIRAGEPIRNFTGEGKLGVVDPRDVAAVAAVALTGGTSGVHTLTGPELLSTPEQVAILASVLGRPLSTVEAAGSEPGYAYVRSGRGAVVTDDVPRLLGRPARTFREWVVDHADTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNY4</accession>
    <name>A0A010ZNY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849252.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1446"/>
    <dbReference type="HOGENOM" id="CLU_070808_0_0_11"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="129"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="37724" checksum="14A07B09E159BDAC" modified="2014-06-11" version="1">MPIPRWFRRVVVAPAFAGILFGLLLTMPIWLLGVGLVSIGLKGRRRLLRVVWLVAVYLVMELVVLIELFGLWLAAGCSATRVRSPKFQVRHYQLVGWVLKIASKQAGRVLKLKITTDGPDPDAHPGRPLLVLCRHAGPGDSFLLTNALINKYAREPRIVLKDTMQWDPAVDVLLNRLPSRFISPNPGASGDAVEAQIAALATGLDENDAFVIFPEGGNFTPKRRAKIIASLKKRGLHRAAQRAEEMIHVLAPRPGGVVAALTAAPEDADVLLVAHTGLDHMLTVADVWRELPMDKTITMRFWLVPAAEVPRDDADQQVEWLYGWWERIDDWIEEHRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPA3</accession>
    <name>A0A010ZPA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849442.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1566"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="13"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="35318" checksum="8CCD82874B7F9888" modified="2014-06-11" version="1">MRTAKLGDLEVGRIGLGAMGMSHGFTGAGTDDAESIRTIHRAIDLGVTLIDTAEIYGPYVNEELVGQALKGRRDQVVLATKFGLVSHTGDRPGNLDSRPANIRTAVEGSLRRLGTDHIDLYYQHRVDPETPIEDTMGALAALVAEGKIRYVGLSEAWIDTVRRAHAVHPVTALQSEFSLWTRDQDEMLPVLRELGIGLVAYSPLGKGFLTGALRTPADIEALDDSDFRKSSPRFTGENFARNLRIADEVRAVADEVGATPGQVALAWIVSRGGDIAPIPGTKRVSRVEENIAADGVELTEKQIATLNDLPVAEGGHHTEAQMAMIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPC6</accession>
    <name>A0A010ZPC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2989052_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="57" mass="6824" checksum="10F17BFA1FBC801B" modified="2014-06-11" version="1">MIALRGYRIAEVDRWVEWAEQHPDQARTAEPPQFNQTLRGYARREVDEWISGLRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPE1</accession>
    <name>A0A010ZPE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_066207_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="25872" checksum="15433D401D0FC37C" modified="2014-06-11" version="1">MTLDAAEASAGAGETPSALPPNLLARMKNDPSHAPEHLVLAAVDKFGPEAALWMARTRAAHPYVPDHVWVPVIRTRFVRLSRYSGAAAGAAGAVGAVFDVGVLAWNQARMVLHIAAALGYDPTHPDRAAELLVIRGLQTKLDAARTAVEVARRQQEPSALAQHLPERVRNFGSGAGRAYTELAWQLARMAGLAAAKKMAMKFVPFAGVPLGAIANSSATKKLAQDAVNYYSAHRQPLALPPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPH0</accession>
    <name>A0A010ZPH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidyltransferase-related enzyme</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847583.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.142"/>
    <dbReference type="HOGENOM" id="CLU_034585_2_0_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="165" mass="17621" checksum="EF7232E139F579EA" modified="2014-06-11" version="1">MPDLPRAGLHLRWFAHPSGSGRPVVVTGAFDVLHVGHLRFLQAARTMGSLLLVGVEADNRVSAWKGPGRPINTDVERAEMLAALRPVDGVFLVQGGPDVKDPEAYVELLRPLDPAVLAFTQGDPFAVEKHRSARLLDAAAVEVPLVPERSTSAVLNGQRAVPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPI0</accession>
    <name>A0A010ZPI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079550_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28362" checksum="1B4E150B0798C5DF" modified="2014-06-11" version="1">MPFVASAGVTITRALSIAYLVYAAAAAAWLWRLGHGLASVGAVCALLAAAAPLFRRRRVLLGVHAVMIPAQFVFSVPSNVPLLGLMLSVAIVVALRPRPGRLSPRTRKVALTVHVGLSVGWLGLAMAMTVLAVVGLTTSDDVLRHDVYRIMHLFDLVIVIPVVVLTILSGLVVSLFTRWGLFRHWWVLIKFVLALAVPMVAGVQHLWIAELIDRTAADPTAVGVRLLVCFALYDVVLWTATALSVFKPGRTTPWTQLTARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ69</accession>
    <name>A0A010ZQ69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079845_0_0_11"/>
    <dbReference type="OrthoDB" id="1875436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="29095" checksum="97CD042F3A070E18" modified="2014-06-11" version="1">MHKPWSVIQAVLAELAAITAVLYYLGWIRAAETFRYFGVDVGILGLSSADYVLRSPPTAIPIIVVLNLLAVAAIELYRTGLGDRLATINRRRLRIALWSVTGVTSAAVVVLYVRYEDWGSRLGVGLPLLLTLAAGAAAGARHTPTPGRLTDALAGAALMVLAAIGLLWAFTLYGAQAGRQAARTFYDELPSRPAVTVYSDKLLVLPGATWTEATKTPADSAYQYRYQGLRLLARTPDGYLLLPERWRRGDAVYLVALGDGVRIDLAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQL7</accession>
    <name>A0A010ZQL7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848220.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.534"/>
    <dbReference type="HOGENOM" id="CLU_008213_4_0_11"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="399"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="553" mass="61343" checksum="D28305D28FEBF442" modified="2014-06-11" version="1">MPNGPLIVQSDKTLLLETDHPDASACRMAIAPFAELERAPEHVHTYRLTPLGLWNARAAGHDAESVVDALVRFSRYPVPHALLVDVADTMDRYGRLQLLNSPVHGLVLHALDRAVLVEITRNKKVSPMLGEKFDDDTVAVHPSERGRLKQVLLKVGWPAEDLAGYVDGEAHPIDLAEDGWTLRSYQQEAVDNFWAGGSGVVVLPCGAGKTLVGAAAMAEAKATTLILVTNTVAGRQWKRELVARTSLTEDEIGEYSGERKEIRPVTIATYQVMTSRKNGEYRHLELFGARDWGLIVYDEVHLLPAPIFRLTADLQSRRRLGLTATLVREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECVEVRVTMTDAERMTYAVAEPEERYRVCATARTKMPVIRKLVEKHQGDQVLVIGAYLDQLDEISAELEAPVIEGKTTNKERERLFDAFRQGEINTLVVSKVANFSIDLPEATVAIQISGTFGSRQEEAQRLGRVLRPKADGRQAHFYTVVSRDSLDADYAAHRQRFLAEQGYAYTIVDADDVIGPPLPDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR48</accession>
    <name>A0A010ZR48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850342.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2213"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="25770" checksum="9E3D853F6A60EE29" modified="2014-06-11" version="1">MTKILVVDDEPQLLRALRITLRARGYEVDTAPTGAAALQTAARRHPELILLDLGLPDLDGIEVIEGLRPWYDGPIVVLSARHTTDDKVLALDAGADDYVTKPFGMEELLARLRAALRRATPAPDALVVTTDAFTVDLAAKRVTAGDHDVRLTPTEWGLLEVLIRNPGRLVSHKQLLNDVWGSAYKQESNYLRVYVAQLRRKLEPDPARPRYLLTEAGMGYRFEPDRRRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRA2</accession>
    <name>A0A010ZRA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2257"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="39183" checksum="9927D5BD1258A8FD" modified="2014-06-11" version="1">MVLNIPEADLTDLRTRLRNTRWATPWPLPPWEAGTDGGTLRRLVEYWASDYDWREHEAAINALPHHVGPVPYLRFGQGFPLLLANGWPSTFLELVDVAERLAAAGFTVIVPSLPGYGTAPQRAALAEAPHTHDLWHTLMHDELGFSRYGVHGSDIGAGDASRLAQAYPEAVAGLHLLDTANPAAYDPAGLTDEERAYLDAENAWAEAERGYSHEQQTRPLTLAQGLSDSPSGLLAWILEKYRAWSDDFAAFSDDFVLTQASLYWFTNSISTSFRPYYERAHQLVPTVSRVDVPTAYARFPADLGARKPRSWVERTYPVARYTLMPRGGHFAAHEEPALLADDITAFFTALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRL2</accession>
    <name>A0A010ZRL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3435871_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="13" mass="1392" checksum="7E4E1E48325FD044" modified="2014-06-11" version="1">MASAARIQGPAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS39</accession>
    <name>A0A010ZS39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2698423_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="73" mass="8144" checksum="898403274E96D4AD" modified="2014-06-11" version="1">MRARIAGLTGWSNTRDRTERARGAYETRRANLAERLDPDGAMRPDERAAAVDSAIKAQMARAAFARSRKAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSB4</accession>
    <name>A0A010ZSB4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="13" type="ORF">CryarDRAFT_1177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848898.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1157"/>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_11"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ThiC-associated" evidence="12">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="518" mass="56562" checksum="BF043037A3AD2A04" modified="2014-06-11" version="1">MSNVVSTGPLPGSRKAYRGALRVPVREIELTNGQVVERYDTSGPYTETDFRPDLGNGLPKRDRTRTHPTQLLAARAGEVTTEMAYVAARENLPAELVRDEIAAGRAVIPANVNHPEAEPMIIGKRFLVKVNANIGTSAVTSSPAEEVEKMVWATRWGADTVMDLSTGPRIHETREWILRNSPVPIGTVPIYQALERVNGDPTALTWEIYRDVVVEQCEQGVDYMTVHAGVRMAYIPLTVGRKTGIVSRGGSILAAWCLAHHQENFLYTNFAELCEVLRTYDVTFSLGDGLRPGSVHDANDDAQLAELRTLGELTKVAKDHGVQTMIEGPGHVPMDKIAENVRLQQEWCDDAPFYTLGPLATDVAPGYDHITSAIGAAMIAWHGTAMLCYVTPKEHLGLPDRDDVKAGVIAYKIAAHAADVAKGHPGAQAHDDQLSDARFEFRWADQFALALDPETAQSFHDETLPAAPAKTAHFCSMCGPKFCSMRISHDLRAAPGMAEKSAEFRAAGNRIYLPVAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSM3</accession>
    <name>A0A010ZSM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851122.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2775"/>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_11"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="482" mass="50905" checksum="42B653610F5FDD51" modified="2014-06-11" version="1">MGTDLVAALQRVVGIEWTYTDPHELRTYESDGLLQYRALPRVAVHPGSAEEVRAVVRLCADAEVPWVARGAGSGLSGGALPVADGVLIVLTRLNRILDVDLDNARVCVEPGVTNAAVSAAVGPGFFYPPDPSSQIVCSIGGNVAENSGGAHCFKYGFTTNYVTGLEVVLTDGELVRLGGEGLDTPGYDLLGAFVGSEGTLGVATKIWLRIVPSPEAVRTLVAFFDSTHAAGEAVSEIVRGGVVPGAIEMMDAVTIDAAERMAHAGYPVGRGAALLVELDGPEDECETLFADVVAICERCGSDDVRVSRDDAERALFWKTRKAAFPAMGRISPNYFVQDGVIPRTTLPDVLERIEALATEAGLTVANVFHAGDGNLHPLVCYDGRVPGEAERAEELAGAILQVCLDAGGSITGEHGVGVDKRKHMTKMFSPSDLDAFQRLRCAFDPAGLANPGKVMPTPRLCGEVPGPYRQHPMEAAGLAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSX6</accession>
    <name>A0A010ZSX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212714_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="37" mass="4191" checksum="ECF6FBDD838D4996" modified="2014-06-11" version="1">MSEQTQRIRLVVSWLLVTVLLGYGIVQTLITAAKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTM4</accession>
    <name>A0A010ZTM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851592.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823415_0_0_11"/>
    <dbReference type="OrthoDB" id="826678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025566">
        <property type="entry name" value="DUF4331"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14224">
        <property type="entry name" value="DUF4331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="299" mass="33033" checksum="9FA87A27D88785ED" modified="2014-06-11" version="1">MSHHLDSPLSRRDPRLNITDQYLFDDRDGTVFVLNTRTSLAGDTAPTGFHEEGRYEFRIHLDGAEIENLTFRFAFDEEGNGLQPYRLCRLEGDDAADDGATGTEILYGHTDRTSDSPDGIQAWAGRALDPFYLDLGQLDLVNRLILRGADSDPTEYKAVNTFAGATVQSIVLRVPHRDRALFAERDIRVWSTTRLATDAGGWRQIGRAGLPTRPEAYADRVVDRIMPDTLPYRVGSPATFGFSVFNGRHLADNAPEVMFSLAMNSAISTGLAPASAVETRSPRFPFVVPAGDASRRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTR4</accession>
    <name>A0A010ZTR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3189"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29573" checksum="7965D15399332FB1" modified="2014-06-11" version="1">MTRARNKVALVTGAARGQGRSHALRLAREGADIIAVDICRQIATVPYPMPTEEDLAETARLVEETDRRIVTAVADVRDLDELTGVVDDAVERLGRLDIVAANAGIHSGGVPTWEMDDQMWQDLVDVNLTGVWITCKVAVPHLIAAGGGSIVITSSVAGMRPFGGIAHYVSAKHALMGLTKTLAQELGQHNIRVNAVNPTQVDTPMIMNPLIYQLFLPDVPEPTKEQFAVASQEGMLLPTPWVEPSDVSDALVFLSSDEARFITGIGLPVDAGVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTS4</accession>
    <name>A0A010ZTS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted/surface protein with fasciclin-like repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569927.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1672"/>
    <dbReference type="HOGENOM" id="CLU_1270064_0_0_11"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458081" evidence="1">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="22692" checksum="229D14478B34FBC8" modified="2014-06-11" version="1">MKLVRLGTQAVAVTAAALLATAVAAAPAAATGKPTPKGNKSLVAVLTADKSGFDRNSKDFDILTAAVKAVLKAKPNSPVKVLADGKTPLTAFVPTDAAFQALVADLKGTHHWTSERQAFTAVAGLGIDTVEAVLLYHVIPGATIDKAAALKSNGAKLKTAAGATIQVCVDGHWKKKTIRLVDADWNDRDPRVVVADVNKGNKQIAHAIDRVLRPSDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTU1</accession>
    <name>A0A010ZTU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849599.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="18126" checksum="7FEF4F5E0B685BCD" modified="2014-06-11" version="1">MATIDRLDVELLSRLMTNARAGVAELAAGLGVSRTTVQHRLRRLEEEGILVGFQPIINLSVIGLPVQALVSLEIDQREMPTIIDGLRELPEVLEVRIQAGREDLLVHVAIASLEELQRLTAAIVRLAGVRKTTSTFTVSTPIPYRVLPLLSDATRHAGWGRSTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU22</accession>
    <name>A0A010ZU22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acyl-D-glucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1758"/>
    <dbReference type="HOGENOM" id="CLU_042253_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="428" mass="47276" checksum="5672B25283B6ABFE" modified="2014-06-11" version="1">MCEAFGGTLTSKKGGPGVAEQIRAARPGGESGIDSAEHRAWLDAERDRLFDFAERSKHPLGFGWLTDDGALDADHPLELWITCRMTHVFALATLLGRPGAAELTDHGVRALTENFRDREHDGWFASISADGPVDDSKAAYPHSFVILAASSAAAAGRPGAEALLTDALAVNEQWFWREDDGMVVDSWNRDFSALDPYRGVNANMHTVEAYLAAADVTGDLVWQARADRITRRVLEWASGNEWRIPEHFDEAWNPLLEYHRDQPRHQFQPYGATIGHGLEWARLVLHLAAASSADDLRAGAVSLFDRAVADGWATDGADGFVYTTDWSGRPVVRDRLHWVVNEATNAAAALWIATGDTRYAAPYQQWWDYAEQYLIDRRNGSWRHELDEHNAPSTSVWSGKPDAYHAVQATVIPQLPLAPSMATALARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU80</accession>
    <name>A0A010ZU80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3358"/>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="37720" checksum="D2EB6D7748D59935" modified="2014-06-11" version="1">MAGGSPCSCQLAAQGDAGVAVEDDENPAVGRYRLRGRERIGSDVGPATAFAAAFARMSDVVEETIIGKPGAVRLALVCLLAEGHLLIEDVPGVGKTSLARALATAVGGTWGRIQFTPDLLPTDITGTLVLHPGGGEEVREGPIFANIVLCDEVNRASPKTQSALLEVMEERQVTIDRDPRPVPRPFVVVATQNPVEMAGTYPLPEAQLDRFLMRIHLGYPDHDAEVRMLRGAPASATGAAPPFDPPTVQALIRQAETTHIADSILSHIVTIADATRNHPLVTLGVSPRGGKAMVAATRVYAAAAGRDYVVPDDIRALAVPVFGHRILLTPRAELDGVDPARVLDDALATAPMIPTGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU95</accession>
    <name>A0A010ZU95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849811.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1809"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="35215" checksum="ABA91AC8FF64BF4C" modified="2014-06-11" version="1">MGTTSIREVAERAGVSVGTVSNVLNRPDAVAPATRERVRRAIDDLGFVRNESARHLRAGRSRTLGLVVLDVTNPFFTDVARGVEDAANDAGLAVILCNSDERRDKEQAYLDLLEEQRVQGVLITPVDVDGDRLSRLRRRGVPVVLLDRHAGEGDYCSVAVDDVLGGELAAAHLRDLGHERIAYVSGPMSLAQCADRYRGAIAGGELEILAGTALNVASGRDAGERLLGLRTPPTAVFCANDLLALGVLQVMVARGLSVPGDISIVGYDDIEFAAAAAVPLSSVRQPRHLLGRTAAELLVAEADAAGPHVHRQVRFSPELVVRASSGPPKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUG1</accession>
    <name>A0A010ZUG1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570436.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3438"/>
    <dbReference type="HOGENOM" id="CLU_905260_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="33038" checksum="8AA9D3FCA89AD200" modified="2014-06-11" version="1">MLKIGLIDEARPGVAGLLAELGATVVGPARADASGPDAGLTRRQVEGSDAIVVQRVPPAAVAGSAAVLHLVLLPGAGFDVSAQEAADVRFDASVTADELGRAVSQLWSDRLVPFEANLRDGRRTARRRRPVLCGSDPTWPAQARRLIARLVAASEGRILRADHIGSTSVAGLPAKDLIDIQMVVADLDEAVEVAEAVRVAGFVRAGRWTGLDRYGVEHPEEVVVDADPGRPVNINIRAVDAPVWRQALLFRDWLRATPSERVEYAALKHGLAAQVAHVDDYSRDKMPWIHAALDRAARWAQRSGWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUG4</accession>
    <name>A0A010ZUG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3442"/>
    <dbReference type="HOGENOM" id="CLU_149116_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="14374" checksum="A53430F49E64FF30" modified="2014-06-11" version="1">MLTADDSAIACSRGGRTGDHCNADAVITCVVHYIIDSTQIEAFERFAHEWMRLVAKHGGVHHGYFLPAEGASDRAEALFSFESLAAYERYRTRFGEDPEFIAADNIREESGCVLRYERTFMRPLLPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUJ4</accession>
    <name>A0A010ZUJ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1926"/>
    <dbReference type="HOGENOM" id="CLU_044071_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="22501" checksum="41C5D6D05A80A2EA" modified="2014-06-11" version="1">MTTATTSIEKSQIHSLTRPNMVSVGTIVWLSSELMFFAALFAMYFSIRASGPGQRLWAEETEHLNVPYALVFTTILVLSSVTCQIGVFRAEVGDVYGLRRWFALTFVMGLIFVLGQAYEYQHLVHEGVTIPANGYGTMFYLTTGFHGLHVIGGLIAFLLMMGRSTLGPFTPAQATSAIVVSYYWHFVDVVWIGLFATIYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVI1</accession>
    <name>A0A010ZVI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="36115" checksum="CD369E7E4D0360C2" modified="2014-06-11" version="1">MSTEHLLRVEQLQVDYPAPRRRTFRAVDAVDLAVRPGETLGLVGESGSGKSTIAKAILGIAPVSAGTISFDGVALDPERVRRRKPVTDIQAVFQDPTSSLDPSKTVGYTVAEPLLAQLDRERRKAGPGEVRDRVAAMLERVGLGGTAAARYPAQFSGGQRQRIAIARALIVDPRLVVCDEAVSALDLSIQAQVLNLLGDIRAERGISYLFISHDLQVVEHLADTVVVLYRGRVMESGPAAAIHRSPEHPYTRALLAASPVPDPVLQRERRAAREAYRGTPARADALGESCAFRHRCPFAVERCAQERPALRATAGGSVAACHRIGELPDLRPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVV4</accession>
    <name>A0A010ZVV4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="14" type="ORF">CryarDRAFT_2448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725702.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2411"/>
    <dbReference type="HOGENOM" id="CLU_013640_2_0_11"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="13">
        <location>
            <begin position="55"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="354"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="332"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG81337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="40940" checksum="D860646D2160322F" modified="2014-06-11" version="1">MSVYGVLRDRALFRLGGGDAETAHERTLSALTRFGRTPAAVAAARRWALGDAPGLARTLFGVRFPGPVGLAAGMDKNGVALPAWAGLGFGFVEVGTVTAHAQPGNPRPRLFRLPEHEAIVNRMGFNNRGAAALAARLADLSAGGSPPLPIPIGVSLGKSKVTPLEDAVSDYVTSLRQVGRYADYVAVNVSSPNTPGLRALQDRAALDQLLAALAAEAQIPGPRRPAGQPVPLVVKIAPDLTDAAIGEVLEVCAAHGVAGVIVSNTTLGRAGVETPEAGGLSGAPLTRRARELVAFVVRETDGRLPVIGVGGVLTAADATALFDAGAALVQVYTGLVYRGPGLVRAINKSVTQRGVGRLGSGDGGSSPLRAPQSDFRGSTEGAVTMEGSATLSGPVAREVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXV7</accession>
    <name>A0A010ZXV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851586.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3140"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="24279" checksum="6836F654BBD05A4B" modified="2014-06-11" version="1">MASKPTVVLVHGAFADSSGWGGTIVRLLETGYSVVAASNPLRSAATDAAQVRALVDSIDGPVVLVGHSYGGVVVSAASVGARNVRALVFVAAFAPANDESAATLSSLYPGSTLGDALRPVQLPDGDQDLYIDQERFHAQFCADVPDDLATLMAATQRPITAGALNEAVTGPQGWESLSSYFLIAGADRNIPAPAQHFMAERAKGVVREVANGSHAVFVAHPDVTASLIDRAAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXZ9</accession>
    <name>A0A010ZXZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3187"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26228" checksum="D1339F73441C4A3D" modified="2014-06-11" version="1">MKLDGRIAIITGAGSGMGRAMAQEFVANGATVVAVDVRTDPVAETVKLLDDGRSVAQTADVSSRADVERVVTEAVERFGRVDILCNNAGVLDDYTPAHETTDELWNRVIGVNINGPFLFSRAALTPMLEQGKGVIINTASISSFVAGGGGAAYTSSKHAVLGLTKQLAFDYGKRGVRVNAICPGAIHTGMTGHLMTADGRNPHVDAAIAATPAGRWGKPEEIAHMALFLASDEADFIHGAAFTVDGGWLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY32</accession>
    <name>A0A010ZY32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3221"/>
    <dbReference type="HOGENOM" id="CLU_3288270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="40" mass="4526" checksum="E52C4B588BDE285B" modified="2014-06-11" version="1">MFWARLRTGFDLDADEICDAFDRAVGTVLARLPEATWAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A024</accession>
    <name>A0A011A024_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852794.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173857_0_0_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="24980" checksum="F7DF7A324B2C21B9" modified="2014-06-11" version="1">MRLGATLAHWSDAPPRDVARWAERLVAAGFESLWTPEIIGRGSFVPDPFVTLAVAATATEGVELGTATVQVPLHHPAELAHRVASLLAVCGNRLTLGVSPGSTATDFALLDRDFGSRFTTLHRDVARLRELLAERPPFLLGSWGANVERAARDYDGWLASGYRRTAGQIRAAHERFRAAGGGRAIVCAVPTTDLEATAAALRGYAEAGFDDAVVLIDPGGPEPAEVRALFPAAPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A042</accession>
    <name>A0A011A042_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of polyketide synthase expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4016"/>
    <dbReference type="HOGENOM" id="CLU_017436_7_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="471"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="532" mass="56962" checksum="F73526CAACF55262" modified="2014-06-11" version="1">MNLGRVVDDLGATLLEHAYGEVDRPEEIAAVVFYDVLDQPVLPADALVLGIGVDASPGLLRALGEQKAAALVVRAPVEVTDELRAAVDDTGVTVLGLRRGASWGHFSDLLRSLLTPGADDGPADEALLGGLPAGDLFAVANAIAALLDAPVTIEDRSSRVLAFSGRQDEADSSRVDTILGRQVPERYARMLHERGVFRELLRGDQPVYVEPIPDRHNGFSIPRVAISVRAGDEVLGSIWAAVPGPLTDERSAALREAATLVALHLLRIRAGADVQRRMRADLLNTALEGGHGAREALERLGLSSQPLLVLGVALDERDNADSAGVIQDRQGLSDAFALHLNAVHPRAVAAAIGAVTYGLLPMTGVPERAETRAVRILQGFVDRVGGRLPSITAVGPVARGLSDVARSRSSVDRVLRVLRDGRPDRRIGRFDELQGEALVSELRELAAARGEKPAGALARLADYDREHRGNLVETLRAWLDAFGDSVLAAEAVGVHQNTFRYRLRRVAEVGQCDLNDPDQRFGLMVQVRVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0B6</accession>
    <name>A0A011A0B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035865398.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4110"/>
    <dbReference type="HOGENOM" id="CLU_033093_0_0_11"/>
    <dbReference type="OrthoDB" id="548749at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="PTHR37489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="36307" checksum="3BBE39567460C6D5" modified="2014-06-11" version="1">MVSAAKEWLDSLDDTQRAQAALPWPSEEDRHRWFYTPVDHGGLPLGRMSAAQQSLAMRLLATGLSDAGYATASTIISLENLLDRDEGWVVTRGSRRRRDPQLYWVRVFGEPGGSGPWSWRFGGHHVSVHHLVVDGVVRASTPCFLGANPADSPLLGGHLLRPLGAAEDLARDLVRSLDEEQFARALLTTVAPDDIVSRNQPRVRFAGADPLSLTPFAKGLPATALTEPQRDQLRRVLGVFLDRIPAELAEREAAKFAGDRLGAVHFAWAGGTERRQPHYYRLQGPRLLAEYDNTQRDANHIHTVWRDPEGDFGDDVLRNHIAAHHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0G9</accession>
    <name>A0A011A0G9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4168"/>
    <dbReference type="HOGENOM" id="CLU_062618_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="100"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="291" mass="30702" checksum="7310BDF8DCC0851D" modified="2014-06-11" version="1">MLAAAVPAVNGRPLNERQQTGQRTTGASSVHWVNAPIDVLGRAAAVLRALSTHEPGGATTSELARATGLARPTAHRLLSGLLGEGLVDRDPAGRWQLGPELYLLGTAAAARYDVTALAQPSVRRLADATGESAFFSVRRGDETVCLLREDGSFPIRSHVLHEGIRFPLGVASAGLAILAYLPDPDVERYLSRAGRTAAHGPEHAPDALRGRIAETRRDGYAVNPGLIVEGSWGMGAAVFDARSEPVGALSLTGVAHRFAPHRRPQLGRLLLAEAHRLSTAVSRPAGAGEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAE8</accession>
    <name>A0A011AAE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847326.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3"/>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_11"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="161"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32822" checksum="90E884F8FE5E2D51" modified="2014-06-11" version="1">MEIGLIGLGKMGGNMRERLRRAGHTVIGYDRNHEIADVGSLTELVDAFTSSPRVVWVMVPAGDPTRDTVKELGELLSDGDVVVDGGNSRFTDDKINADHLAEKGIGYVDAGVSGGIWGLKNGYALMVGGSPENVAKVQPFFEALKPEGDYGYVHAGPVGAGHFAKMVHNGIEYGMMQAYAEGYELLTAAAVVEDVPGVLKSWQEGTVVRSWLLDLLVNALQEDPNLDDIKGYVNDSGEGRWTIEEAINHAVPVPVLAASLFARFSSRQDDSPAMKAVAALRNQFGGHATTKAGQAATAADLGGPGDTIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABG4</accession>
    <name>A0A011ABG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330095_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="22286" checksum="7BEE2DBE0E9DF301" modified="2014-06-11" version="1">MVAWWKSIFGGRSFVDNTIVGVADAALKTDVEAGRNELLRVNSVLRADLERLRVHAGTGPMNTVLLRAAQNVEAFGSAGFAGGRHLFRATEAMAEAGRLIAPTGRPPCLFNPMHGPATAEVTWTPGESMPRRVPVCDEDSVRITTGQAPDVRLVPTDFGLKPYYSAGRLYADWILGWYSGSQANLTLELLAGTDLGAHLPERIQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACL0</accession>
    <name>A0A011ACL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848522.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.784"/>
    <dbReference type="HOGENOM" id="CLU_007946_18_1_11"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459434" evidence="6">
        <location>
            <begin position="27"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="40201" checksum="66C2C3DB44B6A3F8" modified="2014-06-11" version="1">MNSINGTAMYVGAVLGTGVIALPALAAEVSGPASLLAWVLLVVASAPLAATFAALGARYPDAGGVSTYARLAFGPSAASVVGWCFFFAVPPGAAAAALFAGAYVESATGGGRALTAIALIVGAGVTNAYGVRLSGRVQFGLSLLLVAFLLVAVVLSGPHFRTGNLTPFAPHGWGAIAPTVALLVWSFVGWEAITHLTAEFRRPERDLPRATAAAVVVVGVLYLAVAFAVIGVLGSAAGESAAPLGELLAAALGGDARLLAALAALLLTFGTINTYFAGAAKLGAALGRDGALPAWLGRGSSAGEVPRRSLGVLVVAVLAALIGVLAAGIGPGPLVLATTGLFVTVYAVGVAAAVKLLRGRPVAVAALGIVLVLTVLTGKYLLWAAVVAAGALLYLRVRRMPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD50</accession>
    <name>A0A011AD50_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_1036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848746.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1017"/>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_11"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="461" mass="48706" checksum="2F308920CD3C88E9" modified="2014-06-11" version="1">MRYFESVVDLIGNTPLVKLRSVADGVPGTVLAKIEYLNPGGSVKDRIAVKMVEAAEKSGALRPGGTIVEPTSGNTGVGLAIVAQTKGYKCVFVCPDKVSEDKRDVLRAYGAEVVVCPTAVAPEHPDSYYNVSDRLVREIDGAWKPDQYSNPEGPASHYATTGPEIWNDTDGRITHFVTGIGTGGTITGTGRYLKEKAAEAGREITIVGVDPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVTDQVVPVSDAESFLLTRRLAREEGLLVGGSCGMAVAGALKVAREAGPDAVVVVLLPDGGRGYLSKIFNDEWMAGYGFLNLADRTPGGITVGEVLRAKSEGLPQLVHTHPNETVKTAIDIMREYHVSQMPVVRAEPPVMAAEIAGSVSEAALLDALFDRRAALNDAVEQHMGSPLPAVGAGESVDAAMKAVEVSDAAVVLEDGKPIGILTRQDLLFYLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADN4</accession>
    <name>A0A011ADN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848960.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1213"/>
    <dbReference type="HOGENOM" id="CLU_011276_9_1_11"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="270"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="270"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="371" mass="38958" checksum="A77687CC3CD90A5B" modified="2014-06-11" version="1">MGELDGFTVAVTAERRKDELAALLERRGARVVMAPALRIIPLPDDEMLLSTTRGLIENPPDIVVATTGIGFRGWLEATEGWGLADSLLAVLASSTVLARGPKARGAIRAAGLTEQWHAASETSAEVLSYLLEAGVSGKRVAIQLHGEPLRDVAAALTAAGADVVEVEVYRWVPPEDVAPLRRLVESVCAGAVDAVTFTSAAASANFLATADSCDRGPAVVKAFSTSVVAACVGPVTASVLVRRGIPVVSPERYRLGALVRSVSVELPARCPTFRVRDHEVQVRGFAVIVDGVAVAAPPASMAVLRALASRPGRVFSRAELREVLPAGDAGDHAVEMAITRLRAALGEADLVETVIKRGYRLRTEAVLTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADV0</accession>
    <name>A0A011ADV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849026.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_3_0_11"/>
    <dbReference type="OrthoDB" id="1811015at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13107" checksum="E3D8D1A6B343376E" modified="2014-06-11" version="1">MPNRTWYDDEAGPVVRPYAMTRGRTRPAQDLDVVALVLSVQDTVPVGAGFEPEHLHILESARRPISIAELAAHLDLPLGVVRVLIDDLVGAGCVVVRPAPTTAELQSRRLLEAVIDGLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AES9</accession>
    <name>A0A011AES9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849478.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1596"/>
    <dbReference type="HOGENOM" id="CLU_055047_0_0_11"/>
    <dbReference type="OrthoDB" id="1280139at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="PTHR10037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="7">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="33000" checksum="A5F75F430B44928F" modified="2014-06-11" version="1">MIRIVLRRLAGSCREVVAAPWFNLAGFVVIMVNAVALGLETYDPVVSAAGPLLHAVEYACVLGFAAELAVRFGAHLEAPSRFFRDRWNLFDLVIVAAPLLPGVRENVTLLRLLRLARIVRTFRLFPSLRVILVGIRRSLPGLASFLLVTVLVLYGYAMLGWMMFGEAYPERFGTVGQAMLTLFLLLSLDGITDTLEAGREVTSWAVLYYVSYMVAACYLLTNLLVGLVLTALQEAHEDERDAKLVVGSPEHSVREQLAQMRALIDALERQLPPARPAPVRVGGAGSAERSVSSEAAPRELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF11</accession>
    <name>A0A011AF11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-related, FMN binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849592.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1681"/>
    <dbReference type="HOGENOM" id="CLU_054513_0_0_11"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="32060" checksum="52FD77EE7112E151" modified="2014-06-11" version="1">MTTFHRGELSAQKRAGVLHEAARLAPMLERPAIPRGARMFLAEQPMLVLGATDRDGDPWATLLTGPPGFLDVDGPSTLTIAATPGPGDPLREALTEPVPVGMIVIEPDTRRRVRMNGTAHPTPAGLRVELAQVYGNCPKYIQARVPTRTPGAPGVAWRGTELTPADLDFIATADTFFITTADLDGNTDASHRGGNPGFLLASGPTRLRWPDYAGNSMFNTFGNLEVNPRAGLLLPDWTTGTLLHLTGSAVVDWDRAHAAGVPGAQRLVDFTVDRVVRVDNAAGLRWSEAEFSRFNPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG55</accession>
    <name>A0A011AG55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850155.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2065"/>
    <dbReference type="HOGENOM" id="CLU_004785_1_2_11"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1126" mass="117286" checksum="073C11F1C8B5F78B" modified="2014-06-11" version="1">MRPVLLAMDGFGSFREPTTVDFAEADYFALVGPTGAGKSTVIDAITFALFGSVPRWDDKRKVSLALAPTAARGTVRLVFDVGPERYVIVRELRRAASGAVTVKNVRLEHLADPAALGDLEDDTELVAADKEATPAVETLLGLTFEHFCTCVVLPQGDFAEFLHARAGDRQKILVKLLGLEVYDQIAKAANTEAAREKQNADLLGDQLLRYGDATEDAQRAAQARVTALAGAESRVAAALPVLASASAEARTAREAVARLTAERDRLTAVEVPESLGELDARLRSARAEATRAQEALAEAESADSAARAAVAAAPARGPLEQARRAHAELASVRAGRAALVDRQATAATALSAAEARVAAADQAVEQARTAQLEATAGAEAAREAVARLTAERDRLAAVRVPAGLNELDARLRAAREVASRAAAALTEAEAADSAARAAVSVAPPRGPVEEARRARHELDAAVDGRPALVERRSRAAAGLDAAERTVAEAREAVEQARAARESDARARTAAVLRPHLVAGEPCPVCEQTVATLPPPLDDQAGTADADRRIAAAQRAADTAAADRSTAAAVLRDAEAALAAADETIARRQAALGAESLRVTVHGDGAGSVEILGLADLERWLTARDALDTAARAADRELVAARSARADADRDAAKVDAESSGVRTALRETRDAVAALGAPAGLVEDVAAGWDALATWASSAAAERTTALTAAGRAETTAAKALTAAEKTLAQTQQQLADARRAHTEATRAEQRAAAELTAADRTAETLTAQLGDAPGAEELARSLAELDALDTEVRAADERLRTARTALGAAQRTAKEAYEQVAATVRGLTAVREPLVALGAPAIPSDDPVGGWRAFADWASAAAAERVDQLAEAEQTVHTADRALADHEQALRDLLADLGIPLPADGAALPSARPVAEIAPTAVARALAEARAAEARITERRTECADLVQRRDAAETAQQVARQLGQLLRSDAFPRWLVASALDLLVSEASATLAELSGGQFALTHEAGEFVVVDRADADSRRPVKTLSGGETFQASLALALALSAHLSTMAASGAARLDSIFLDEGFGTLDEATLEVVAATLENLAAGGDRMVGLVTHVAALAERVPVRFEVSRDQRTSVVTKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGB2</accession>
    <name>A0A011AGB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">CryarDRAFT_2161</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850218.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2127"/>
    <dbReference type="HOGENOM" id="CLU_018868_0_1_11"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG81066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="552" mass="59311" checksum="AF65CD069C9F71F1" modified="2014-06-11" version="1">MDGARPVRAARGTSLTAGSWQTEAPLRMLMNNLDPEVAERPDDLVVYGGTGRAARNWASFDAMVRTLTTLKDDETMLVQSGKPVGVMRTHEWAPRVLLANSNLVGDWATWPEFRRLEQLGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAERKFGGTLAGTLTVTGGCGGMGGAQPLAVTLNGGVALVIDVDPARLHRRVEQRYLDEVAPSLDAAIERALEAKKDRRALSIGVEGNCATVLPELLRRGVDVDVVTDQTSAHDPLSYLPEGIDLADWHDRAEKDPADFTVRARASMAKHVEAMVGFLDAGAEVFDYGNSIRDEARQGGYDRAFAFPGFVPAYIRPLFSEGKGPFRWAALSGDPRDIHATDEAVLDLFPDNDHLHRWIRAAQDKVAFQGLPARICWLGYGERDKAGVRFNDMVASGAVSAPIVIGRDHLDCGSVASPYRETEAMADGSDAIADWPLLNALVNTASGASWVSIHHGGGVGIGRSIHAGQVTVADGTALAGQKIERVLTNDPGMGVIRHVDAGYDDATEVAAARGVRIPMREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIF4</accession>
    <name>A0A011AIF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851197.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2843"/>
    <dbReference type="HOGENOM" id="CLU_001265_62_1_11"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="435" mass="46040" checksum="E98D8C23C32C9AFD" modified="2014-06-11" version="1">MKGRSVSNQARGAWIVWLVGLSIYFVAVFHRSSLAVAGLLATERFDITAAQLATFTMLQLLVYAAMQIPVGLLVDRFGSRAVLLTGATVLTVAQAGFALAGSYQAALLARTFVGIGDAMTFIAVLRLVNVWFAPQRVPLVTQLTGVTGQLGAIVAAVPMTWALSNLGWTWAYGIAASLGLATAIAGLLFLHDEPGTRTLRGPALSLGAIRTSLATSWQQPGTRLGFWVHFTTQFSPTMFALLWGFPFLVKGEGLSPNVASLLITLMVLSLIAAGPVMGWLTAHHPWQRSTIALGVVGAIVAAWTLVLAWPGRAPLPVLVLLVVVIGLGGPGSMIGFDLGRTSNPVERLASATGIINQAGFVATLTMVVAVGAILDQRSGGGSAGYTPDAFRWAMSFQYVLWALGAVQILRYRVKGRAHALRLDPLARTRTAFQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKL6</accession>
    <name>A0A011AKL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852372.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3672"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_11"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458562" evidence="1">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="437" mass="46631" checksum="F538A168A60EFC02" modified="2014-06-11" version="1">MKRLTAAVAAVLVLSACGGTGGGDQKVADAPGDNDKVTLTVWSGFADKELAALDAVLDGFHQRHPNITITSQGSQDDDKISQAVRGGTAPDVAISSNANALGQYCKTGAFQNLQGYLDRDKVDLSVFPQAVRDYTEHDDVRCAMPLLADAYGLYYNKTLFAEAGITAPPKTMTELAAAAKKLTKFNADGSIKVAGFVPTLGFYNNRVDVWAPQFGAEWQDSRGKSSLSTSPGWTNLFQWQKQLTDFYTEKKLTAFTAAAGQKYSPDNAFQTGKIAMMFDGEFRTGFVDSEAPNLDYGTAPLPVSDDRTDTYGGSDVGGNIIGIPKGAKQAGAAWELIKYLTTETEPLVALANGLKNLPTTTDALKSPDLKFTGTLAPFVDIFTNPNSSSLPTTPNGAAYLKTTLDFAVKWQTGGAPDLKKGLKDADTQIDDDLALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKV5</accession>
    <name>A0A011AKV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852514.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3757"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="446" mass="47205" checksum="6CAE340FB098589D" modified="2014-06-11" version="1">MTPHFDGSLLTGGDPGYDAARTVWNAMIDRRPRMIVRAASVADVVTAVRLARESELELGVRCGGHNAAGFAVPADGLMIDLTRMNAVRVDPVGRRATVQGGALLGALDRASQPYGLATTSGNVSHTGVGGLTLGGGMGWLARRYGLACDNVVSYRMVTADGEVVTASRTENPDLFWGLRGGGGNFGVVTDFEFALHHIGTRALVAELDFPAEDAVPVLEGWRDLNADAPREATFTADVRSAPGGAIATVGFVWVGDPARGARLLPGLRALRCPVAERVTTPSYRELQSRDDSTGGHTYRRYSSAHYLREFSTAAIEAFLLRGAADVGTGSFRPDVGLQAYGGAIADVADADTAFSYRGTRFEFGAGSRWTDPAEDDARIAAARAAGAALGPHADGVYVNSLSADEGRRGVRRAYPAAKLARLSDLKSVWDPRNVFHLNHNIPPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKX5</accession>
    <name>A0A011AKX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570608.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_5_1_11"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16243" checksum="ED6B81542176483A" modified="2014-06-11" version="1">MNDMPTVDETAPVISRHELTTPASAEDVWRVLTDIDSWTTWLPDISHAGLETPGPLAEGSVFRWVAPGRDVVSTVVLARPFERLVWTGQVNGPGGISGVSAWTFTPGGDGLLVSAAESLAGPPAEAAAEQIQPALDEGLARWMRFLLNAAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFR9</accession>
    <name>A0A010YFR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847499.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2166762_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="110" mass="11560" checksum="2DF317B0F003E39C" modified="2014-06-11" version="1">MGDSVFSFGENRVGGDQYNQNGTTNIGKIESHQSVAIRELNDFLAWAEEQGLVLPGGLVTDENRLRATVRSHPGRLRRVAAAVAGGSKDALMKASPGIATTLILQALGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFY5</accession>
    <name>A0A010YFY5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0163</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847591.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.155"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_11"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="180"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="479" mass="51973" checksum="610B30AC1BFB3C27" modified="2014-06-11" version="1">MTATADIGVTGLAVMGRNLARNLARHGHTVAIHNRSPEKTRALVSDHGYEGTFVASESMADFVSSLKRPRAVIVMVKAGQPTDDVIDELIPLLEEGDIVVDCGNAHYADTRRREDALKKHGLHFSGTGVSGGEEGALKGPSIMPGGSKHSYEKLGPIFESIAANVEGVPCCIHVGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRSGLDATPGQIAEIFREWNKGSLESFLIEITADVLAHVDGRTGRPFVDVVLDQAEQKGTGRWTVQSALDLGVPITGIAEATFARSLSGHAEQREAARDVFPSTNELAWAADDREGFIEDVRKALYASKVVAYAQGFDQIKAGSDEYGWDVDRGAIASIWRGGCIIRARFLDRIREAFDENKELPTLLASPYFVKAVSDGVDSWRRVVSDSAKAGVPTPAFSSSLAYFDGLRRRRLPAALIQGLRDNFGAHTYRRVDAEGSFHTLWGSDKTEHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGJ9</accession>
    <name>A0A010YGJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="10"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="24117" checksum="831830CBECC67436" modified="2014-06-11" version="1">MPVTSSSLVLQLSGVRTRAGRAGALDDVSLSVEPGQVVAVVGGAGSTLFDTVCGFVRPEAGEITWRGSALRPRPHRLTTLGGLARTLQGVGLYGGLTVLENVLVGAAGVPPVAAVPAGRHGGVGVALLGGAQLRPRGEELRQLARDALTRLGAGEYLDAELAAVPTSLHIRVVLARALLVGPELLVLDDPTAGLEAAEAAALAGMLRPQAGSDHAVLITTTDAEFAALSADRVVTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHN1</accession>
    <name>A0A010YHN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848532.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="31270" checksum="4DDAB0285B9D950C" modified="2014-06-11" version="1">MRTLVSASTLVRHRVLYWTVFGGVVAAFVLAFLFPVYWMVVGAMKSPEELVRTPPTLVPSQWHPETYRDAWDTLDLATHLGNTALQAAGAWALQLVFCTLAAYALSRLRPVGGRVILGGILATLMVPASALLVPKYLTIVDVPLVHVNLLNSPLAIWLPAVANAFNLYLLKRFFDQIPSELLEAAEIDGAGAVRRLWHVVLPLSRPVLGVVSIFAVVAVWQDFLWPLLVFFDTNKSPISVALVQFSYDAPVSHVIAGMVIASVPMVALFLVFQRHIIAGIGAGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIE6</accession>
    <name>A0A010YIE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848798.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259682_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="23468" checksum="D96E429B296AA023" modified="2014-06-11" version="1">MSRFAYIVLDRLVDALLAAWRRSGAEDRWIGYHQARGRRERLSWPEYRTERREWRDAMAAHEGEPAGAVPGPWFFAALLAVLVMVAGYFGSAAAGLISVASVMVSRRALTGGSPRFEATPATFAGAIIAESERQLAAWKALPPGKRRSAAEQDAYLDGLFAAIAVIEETTGRDLLGLFDPGPEVSGQPVTGRPVSAPSGQVDGDLSHPVPPARSADRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIF1</accession>
    <name>A0A010YIF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">CryarDRAFT_1100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725662.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1082"/>
    <dbReference type="HOGENOM" id="CLU_114342_1_0_11"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="13973" checksum="00CF0304EA20B655" modified="2014-06-11" version="1">MAHVSGEKQIVAAVSAGGVIGALARYGLSVAWPHGPGGFAWSTFVVNVSGCLLMGVLMVVITEVYPDQRLVRPFLGVGVLGGYTTFSTYVIDVGHNATSGAAAIGLAYFFATVIGALVAVWAGAAGTGYVLARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIK6</accession>
    <name>A0A010YIK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848872.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1131"/>
    <dbReference type="HOGENOM" id="CLU_000022_23_7_11"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="552" mass="58904" checksum="7B45FE343576EE91" modified="2014-06-11" version="1">MPPDRMSPLSTHLAHWARSTPELPALTFLDYASNPDGVARSLTWAQLDERVSTVAARLQRTVRRGERVALMTPSGLDYVAGFLGALRAGAVAVPLFPPDLPGHEERLAGALADCEPACVVTTSAASAGVRAFLAALDLAPDVVDIDLVRGPEACEPVDVDLDEVAYLQYTSGSTREPSGVMISHRNVVANSHQGFALYGVEPGRSTLISWLPLYHDMGLVLTACGGIVYGVPAVFTDPVAFLVRPVRWLELLSRYPGGITAAPNFAFDYCASRITPGERADLRLENADLIINAAEPVSADTLDRFAATFAPHGLRPDVLSGAYGLAEATVLVTCWSYEEPYRVRTLDVGGDRRMVACGYADNPEGARLAIVDPSSGVRCADGQVGEIWVTGPNVALGYWKRPDADAFGASLDGRPWLRTGDLGVLVDGELYVTGRIKDLIVVDGRNHYPQDVEATVESADPVVGRHRVAAFPVPVADGEGLVVVAEVSRHATAWVTSSVASAIRSAVSSRHGVSVHDVVLVVPNDVPRTSSGKIARFATRERYLDGSLVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJM3</accession>
    <name>A0A010YJM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849321.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1487"/>
    <dbReference type="HOGENOM" id="CLU_151846_0_0_11"/>
    <dbReference type="OrthoDB" id="2043951at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="110" mass="10767" checksum="6FCD7B5D8E5F6EB9" modified="2014-06-11" version="1">MSELAPEDAKIVTLARSTRARNGTPEGAAVRDTDGRTYAASSVALPSLGLSALQVAVAMAVSSGAPGLEAAAVVTTSGQADAEGVAAVRDLAPGAYVLVADPSGTVVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKG0</accession>
    <name>A0A010YKG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849753.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1777"/>
    <dbReference type="HOGENOM" id="CLU_068419_0_0_11"/>
    <dbReference type="OrthoDB" id="1538974at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="118"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="31538" checksum="41F7A1CF74D6C94C" modified="2014-06-11" version="1">MNLRLIAGIGGALVVGGVVLGVFALIGTARPARPTSASVLWWRRVWNGEGLNAHDRRIRRALLLGSLAAGVLGWLFTRMPIAGLLAAVAVPGVPWLFTVGNSEKRAIQRIEAVGEWARRLKDISATGVGLQQAIVSSTATAPAAISTEISTLAARLQAGWNGRIAMLRFADEIADPVCDQVVAALILHLSDRGEHLGDVLNSIASAAAAEVATRREVEAKRTQPRFAVRFLTGLTVLVLVYGASRPDYMAPYGTTTGQLVMAGLGGVFIALLAWVRAMSLPPRAPRFLSVPASPEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKP6</accession>
    <name>A0A010YKP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(Acyl-carrier-protein) S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849849.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1832"/>
    <dbReference type="HOGENOM" id="CLU_030558_1_2_11"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="31219" checksum="EFEAF7A57ED4D829" modified="2014-06-11" version="1">MLALLAPGQGSQKPGFLTPWLTGWDGADRATAVLGDHSAATGLDLVRLGTEADADEIRDTSKTQPLLVAAGLAVAAFLPIERASVVAGHSIGELTAAALAGVLTPSDAVSLAAARGREMAAACALEPTGMSAVLGGVEAEVLERLDSLGLYPANRNGAGQIVAAGPLPALAKLSDDPPARARVIALQVAGAFHTPFMGPARDALGALDVSVAEPQRTLLSNSDGTAVDSGADAWDRIVRQVTSPVRWDSCQATLLELGVTAAIELAPAGTLAGLAKRAMKGVQVVTVNTPDDLPAAAELIAAHSSEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL33</accession>
    <name>A0A010YL33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850075.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2421975_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="9201" checksum="CF2643FBB8554362" modified="2014-06-11" version="1">MSRSKTKTDALTAEERALLDSVSEQAALLAMLTGSVPPAGDPPVGTVDLIGALGPLEHPHTPGSDPLQAFGLVAPRFARDAESVAAELGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLK9</accession>
    <name>A0A010YLK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850288.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766528_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="69" mass="6908" checksum="E64B76D55A6B3380" modified="2014-06-11" version="1">MTSHDAPAGAAGPGIWGNLGIWIAFGALFGVVVGGFFDNVGLGVALGPSLGVAAWAVFIGPRLKARRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNY0</accession>
    <name>A0A010YNY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347027_0_0_11"/>
    <dbReference type="OrthoDB" id="1394285at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458869" evidence="1">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="203" mass="21523" checksum="0AACFEE7CD927F60" modified="2014-06-11" version="1">MRGRLLLLAPFLAGALVAPPAAAAAEPPDGQFSVQAIAGTGCRPTNTQVRLRDLSRVDVSFAALQAQQGRGVPATSRRSTCIVSLRAPVVRGYTFGVDNVLLRGRATLPPGAGATARAGTWFVGLPRTETTDRELTGPFDAIWDLRRVVRPGSISWAPCGRNTPVNLQVDVSVTGRPGVVGRISMDAGTNEPSASYRFAWKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPV8</accession>
    <name>A0A010YPV8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863368.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087604_0_0_11"/>
    <dbReference type="OrthoDB" id="1142673at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="23649" checksum="BAB4DC0FC30C11C2" modified="2014-06-11" version="1">MFDDLRQRMAAKRVRPGDGRPLERFRWWQLFTGRKLFSLQVGETAYAVDVRLTGKQAGDDGMAHLFVNGRHQARSRMPAAFPVAGGTIQVAQSTVGLKRAHYVTTQGGEYLLTPDPRSVIGRRLRFAREHRVLSRWIAAFSVVALVCGLGINLVQLLEPILGVPPIVERFGRFESPIDLPVWVNVALGAAATLGAVERSWRLRHNWLDSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ46</accession>
    <name>A0A010YQ46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose utilization ThuA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851992.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3427"/>
    <dbReference type="HOGENOM" id="CLU_057383_1_0_11"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457638" evidence="1">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA" evidence="2">
        <location>
            <begin position="98"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="33437" checksum="81041ED4EAC9B3FC" modified="2014-06-11" version="1">MDLRRLSLFAVLAAALAVLATGLPGAARTVQAPPSAGGAKELGDPDYGVCRGTDARCYHDWGNFDPAKGYRVLLYTRTAGPRHANLGPALGAGLNPTLTAANVVQNGVVALGEKNGFTVDWTEDVTRLATPSALFKYNAVIFFSTSRDTLDGAAQTALRQYVRGGGGFVGVHNAFGTEYNWPWYEGLLGNANFYDHGPAQPGVVQTVGRSTGLPARWNFTDEWYNLVPAPTKVRVLATVDEPTLKQGVRGSQGHPGHGRNHPVAWCQYYDGGRAWLTTLGHGADIFGTGAEAQNFQTLLSGGIESAMGEKPFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ92</accession>
    <name>A0A010YQ92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852086.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3494"/>
    <dbReference type="HOGENOM" id="CLU_000960_34_1_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="488" mass="49486" checksum="95B930BD19C38252" modified="2014-06-11" version="1">MRQRTIETADAGLHTKWNARLIGLVAVLALVSFVADSAVSAPLLVLPEMLDHFDTDQVGWLNASATLAGVAWAPLLGKSADIHGRRKILVLTLLISGAGAVLCAVAPSIWLFVPGRMLQGSALAAVFLAVAIVRSLCAPRIGLIVVGIVTSGSAVLNIASRFLIEKLAEDYGFQILFVLAAGVAFAMALAVRALIPESSITTPGTIDFSGALLLGGGLAGVLSYISLGSGLGWLSAGPLALLVGGAAALAWWFLVSTRKPDPLIDIRNLGKPLGLTLFIVALGAGAFQSMLQLISLISDVSPDEDLGYGLAGTGSVAILLGSAGIGIMVGGPLAGWLAARLGPIPALAGVVTLGTVVSVGMFVGASHFAFALCCALALGVVAGALLTSGFNTAGTLASPERQGVVSGLIMVSVSIGSVVLDFVGAAMLKFTAVAVDGETSNSATGVYSYIAFASGAFAVATVLVIMLGRTTRRRGDSSSPEPERAAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQE0</accession>
    <name>A0A010YQE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3554"/>
    <dbReference type="HOGENOM" id="CLU_018204_9_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="241"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="394" mass="43322" checksum="9F6A0494F4DF487C" modified="2014-06-11" version="1">MGLTRSSEDAFPEERAFREEVRTWLADNLTGEFAALRGLGGSGREHEAYDERIGWNRHLATHGWTCLGWPTEYGGRGLSLLQQVVFHEEYARADAPARVNHLGEELLGPTLIALGSEAQKARFLPRIVDVTELWCQGYSEPEAGSDLSNVRTRARRDGEEWVIDGQKIWTSLAHHADWCFAVVRTEPGSRRHAGLSYLLVPLDQPGVEIRPIQQLTGTSEFNEVFFSGARTRADLVVGEPGDGWRVAMATLGFERGVSTIGQQVGFARELAVIVAEARANGSFDDPLIADRIARAKLGLEVLRTHALRTLSGDPGPGAGPVQKLLWARWHRDLGELAMGVRGAAGLTVGPPYDLDDAQTLYLFSRADTLYGGSDEVQRTILAERVLGLPKEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRK9</accession>
    <name>A0A010YRK9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4014"/>
    <dbReference type="HOGENOM" id="CLU_061573_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="PTHR41700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28202" checksum="D279457475D22A84" modified="2014-06-11" version="1">MTDHPTQTAEAAAHKAGVVVRELTDMVRITEAVDLLASIWGRAANPPVTAELMRAFSKAGNYVTGAFDDDRLIGACVAFFHEPAGSALHSHIAGVSRDAAGRGVGFALKLHQRAWALQRGVADIVWTFDPLVARNAYFNIAKLGARPAEYLPNFYGAMSDAINTGEDSDRLLVHWRLREYDDERPGTPPGAGVSLAVGADGGPLPSPVDGPVHLVAVPRDIEAMRADDPALARRWRIAVREALTGQIEGFDPAGFYVVRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRY1</accession>
    <name>A0A010YRY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4151"/>
    <dbReference type="HOGENOM" id="CLU_026775_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="151"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29342" checksum="C6A3A5A59FE39F54" modified="2014-06-11" version="1">MSQTHSPQGLVPVLAGDPEGIVDEWTAIVADSLRGRVSRAEVRSELADLYRALQAGLDDAADADPFGELRALLSELSRARAIQGFSPRETAVSVFALKEVVGRRAGDDTPLSGFLEFSRLIDDLGLQTFEAYSQAREQIIAEQAEQLLELSTPVVKLWDGIIAVPLVGTLDSARAQAVMEQLLEALTSYDADYAIIDITGVPAVDTQVAQHLLKTVMAARLMGAEAIISGIRPQIAQTIVALGIEFGDIATKSSLADALSLARRRQDAHRAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV44</accession>
    <name>A0A010YV44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.41"/>
    <dbReference type="HOGENOM" id="CLU_024920_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="9">
        <location>
            <begin position="334"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="526" mass="57558" checksum="CDF98E3B7A7D0AD4" modified="2014-06-11" version="1">MPDLAAPPAPSAVAPPATIAPTPVETPEAVANALAPTLESSLVREPGGVQRSPRTRSGTRHPRWAHRYRLLLLLLDFLSCSAAGWFVINSYEQAGSGFFDRDVLNWTALVILPASWVLSLWVHGAYESRYLGLGPDEFKRVFKAIITLTAIVCFLAFTQKADLSRLSVGTVLPLTAVVTLLVRFGTRKVLHVVRKRGRASQRILLVGTLGEALSVYRITTRNPNAGLVPVGICLTEPTAEVASLPIPVFNGTVEPMDRVKQVGADTIAVCGARGVTPDALRRLAWQLEGSGIELVVAPALTNIAGPRVHIRPVEGLPLLHVEEPTISGVGWLLKGLLDRLAAFVGLLLISPILGVAALAIKISDPGPVFFRQARAGRGGETIRVWKFRTMYVDAEQRLAELLGSNETDGLLFKMANDPRITRVGHFLRKTSIDELPQLINVLLGEMSLVGPRPLPVKNEEFNGDVRRRMLVRPGITGLWQVSGRSNLSWEDAVRLDLYYVDNWSLAFDFMILYKTLFAVMKRDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVC8</accession>
    <name>A0A010YVC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847552.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.122"/>
    <dbReference type="HOGENOM" id="CLU_035117_0_4_11"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="162"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="28838" checksum="34168C01113F3DE8" modified="2014-06-11" version="1">MGQTTVALLGTGAMGAGMAKNIAAAGLPLRVWNRTRARAEPLAEVGAVVADTAAAAADGADVVVTMQFDLDSVVEVISAAAPAPGTVWIQSATVGIDGAAQLAELAAERGLVYVDAPVLGTRKPAEDGTLVVLASGPDDAHERCAPVFDAIGSRTLWVGTAGQGSRLKLVANLWVTTATAATAEVLSLAGALGLDPSLFFRAVEGGGTDMPYIHLKGGAMLGGDFAPSFTVEGAAKDTRLIVEAAAENGLELPVARAVAGQFEASVEAGHADLDMAAAYLNYRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVY1</accession>
    <name>A0A010YVY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847822.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124874_0_0_11"/>
    <dbReference type="OrthoDB" id="1535683at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20347" checksum="85081FD677A64B22" modified="2014-06-11" version="1">MALPVARTRDEAHLYMDMRPCPSCGKSDVQWDSALTSDEGSPARRYTGSCSGCRAPREFVFRLPERPLLPGPGDVVLFGGDDPSELLDAGEWLYVADVCAQAAAGGPDREPGPVLSAEARESLIVAVAAMDEVLKFIPPDKDEVPRAGFWSDRGRTLRQSEPGRFRRPRLQTIRSTYRDALARAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX02</accession>
    <name>A0A010YX02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848458.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.712"/>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OrthoDB" id="1060221at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="33115" checksum="C258BBB96E6AE54E" modified="2014-06-11" version="1">MTPEPGAGPTVLRILLGSQLRRLREDRNVTREDAGYAIRASESKISRIELGRVGFKERDVSDLLTLYGVTDPAERDALLSLAREANQPGWWHKFGDILPQWFQAYVGLEAAASLIRTYEVQFIPGLLQTEDYARAVVLLGNGSAPKEEIDRRVQLRMERQQLLDRPNAPRFWAIIDEAVLRRPIGGRDVMRAQLELLAELSERPNVTLQIIPFGFGGHAAAGGAFSLLRFPDQTLPDIVYIEQLTSALYLEKREDVDTYLESMERLAVEADSPDRSRERFAEIRKDFDLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX07</accession>
    <name>A0A010YX07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848460.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.718"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="35243" checksum="3FEEAE38118B6F6D" modified="2014-06-11" version="1">MRAMVQTGFGGPEVVTAQDVPVPTIGADEVLIRVAACAVNRMDLLQRQGPALLPGFALPHVPGMDIAGTVAEVGSAVSDLTVGSRVVVDPVLGCDECTYCVAGDFGYCGDVRVTGGNRPGGYAEYVAVKAVQTHPVPDEVELTTAAALPSSWSTAYHALFPVGRLAAGETILIQAAASAVSIAAVQLAMEAGAQVVAVAGSQAKLDAVRALGVEHCVPLDADPVAYVRELTGGRGAQIVLDHVGPATWPLSLSALGVRGRLVFMGQTSGNEVTFGLTGAYHRELSLLGSGAYTPEDFHRALTAFWYGKLSAPIAAVLPLEGLSEAFDVLTDRTTVGKVLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX47</accession>
    <name>A0A010YX47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase with GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.754"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="405" mass="43418" checksum="8F04033C5A8488AD" modified="2014-06-11" version="1">MSVAGAVRAEEARLAVLRGHEILDTAAEPEFDDIAMLAAEICGTPIAMVSLVDSDRQWFKARVGVDAPETCRDAAFCAHALEQPDVLEVPDAASDPRFAGNPLVLGEPFIRFYAGAPLRVENGVSLGTVCVIDQQPRSLTAPQRRALRALARHAAAEIELRSYARRTADVTRRVVELEELKNRILTTVSHELRTPLASIRGYLELLLDDSDPLDPQTGRDFLAVMQRNAHRLTQLVDDMLLATKVGAGGLELNRSPIDLTELVAAVVAGSRPLAEHKGLAVIVDRPEQVIVCGSHRELTQALQHVLLNAIKFTSDGAITVQIADASAPTVIVTDTGSGIDDVDLPRLFDPFYRGETAEAAAIQGPGLGLTLVRAIVEAHGGQVDLRSRLGAGTSVALRFPPCDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX76</accession>
    <name>A0A010YX76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative divalent heavy-metal cations transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848524.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.786"/>
    <dbReference type="HOGENOM" id="CLU_015114_6_0_11"/>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="24906" checksum="9CF6FB455E8E7A22" modified="2014-06-11" version="1">MIPTWLEAGLWGLLGGAALVIGAAVAWWIPVRRSIVAAIMAFGAGVLISALAFDLVAEAADNAGVGPTTIGFLGGAVVYVLANVALDRRGARHRKRAGDEQPSERQQGGSGMAIAVGALLDGIPESVVLGVSLLGGAQVSTAVIAAVFISNIPEGLSSAAGMKAAGRSARYVFGVWGGIAIASGVAALVGYAVLGGASATVLAVITAVAAGAMLTMIADTMIPEAFARTQILTGLVTSLGFLTAFAIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYA2</accession>
    <name>A0A010YYA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureA</name>
        <name evidence="6" type="ORF">CryarDRAFT_1259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848995.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1240"/>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_11"/>
    <dbReference type="OrthoDB" id="1826954at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="11229" checksum="EEACDCAE312DA65B" modified="2014-06-11" version="1">MHLTPHEQERLLISYAADLAQRRRQRGLRLNHPEAVAVITSFLLEAARDGRTVSDLMEAGRHVLGRDDVMDGVPEMIEEVQVEATFPDGTKLVTVHHPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYF4</accession>
    <name>A0A010YYF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569832.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2000101_0_0_11"/>
    <dbReference type="OrthoDB" id="1878314at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="12712" checksum="8DF338C1468DA3C4" modified="2014-06-11" version="1">MTLTSIETAVLVTVVGTPGTAASLADQLPPHWRVESADLADVDHTDLLVIGGASGARVRAAVRQHPGTPVVGVVDPYATAEQVVEVLEAGADACVRSGLPALVGSHLRACHRRQAAAGHRQQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYI4</accession>
    <name>A0A010YYI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849059.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="24077" checksum="B827391B2E8037A2" modified="2014-06-11" version="1">MISCVVDAKQMLSGRVYDVLRDAILGGDFAPGDALKPQELAGEHGVSLAVVREALVRLVGDGLADRRTNRGFAVPLQSDRRWQDLAEARCVVEVAALRLAIERGDLEWEARIRASHHRLAGTPAFEGTRVTAEWSRAHRDFHRALLEGSGNAVLLETFDRMWLAGELARRWSSGRAPERDYLGEHRELEEATLARDAETAAALLTRHLTHTVDALGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYK6</accession>
    <name>A0A010YYK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1327"/>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="221"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="591" mass="66170" checksum="A4B467D60CA4429E" modified="2014-06-11" version="1">MRSNVNGSIEDYAVIGDLHTAALVGRDGSIDWLCLPRFDSAACFAKLLGDEENGHWQIAPAGEATCTSRKYRDDTLILETIWETPEGKVRVIDLMPPRDDAVDVVRVVEGLEGQVSMRSVLRLRFDYGRIVPWVRHINGEFAAVAGPDAVWLRSSVPLHGENLSTVGEFTVSPGEYVPFVLTWRESWQENDRDVDAIEQVNNTEAYWRGWVQQCRYEGRWADAVTRSLITLKALTYDPTGGIVAAATTSLPEQIGGPRNWDYRYCWLRDASFTLQALVSNGYDQEAVAWRDWLLRAVAGDPADLQIMYSIKGRRRIDEWDVPWLSGYENSAPVRIGNAASEQLQLDVIGEVLDSLHFARESGISSSEDAWSLQKRLIQHLETTWREPDNGLWEVRGERQHFVHSKVLCWVAFDRMVKGAEAFGQHDDAERWRVIRDTIHAEVCARGFDRTRNSFTQYYGSAGLDASLLLIPRLGFLPADDPRVIGTVEAVQRELVADGFVLRYRPEQEAVDGLPGQEGAFLACSFWLADALYLIGRKDEAVALVDRLVGLANDTGLLAEEYDPIARRHLGNTPQAFSHVALVNSAVLLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZB5</accession>
    <name>A0A010YZB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_3_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="291" mass="28673" checksum="37805D7474DE56D7" modified="2014-06-11" version="1">MPVGPPSGASVGAHPGSLHGVPYGVPHGVPYGVPHGVPYGVPPGGAGDGRRRWPGAVAAGLLVIALSAGAGGTAGHLAGADEPRSETVATSTAQMVTAAARALPGVVSVQVRDGSRGASGSGFVFDDRGHIVTNNHVVAAGGSVSIVGNDGRRYDAEIVGTDATSDIAVLRVTSAARYEPLDLADLSRTRVGEPVLALGSPLGLSGTVTAGIVSALDREVRLGGSTRQTAVQTDASINPGNSGGPLVNSRGEVVGVNTAIATLEGSGSIGIGFAIPIDRARQVAATLISRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z267</accession>
    <name>A0A010Z267_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trehalose/maltose hydrolase or phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850870.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2598"/>
    <dbReference type="HOGENOM" id="CLU_006285_2_2_11"/>
    <dbReference type="OrthoDB" id="179460at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="327"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="700"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="592"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="787" mass="85964" checksum="B88451E33FECE5E9" modified="2014-06-11" version="1">MIGDSPFAVEPWAVREPSVDLDRLGVSESVFTLSNGHIGLRGNLDEGEPHGLPGTYLNSFCELRPLPYAEGGYGYPESGQAIVNVTNGKLIRLLVDDEPLDVRYGQVVEHERVLDFRTGLLTRDLHWVSPAGKAVRLRSERLVSLVQRSIAAISYTVTAGDEPVQLVLQSELFANEDLPAAEDDPRIEAALARPLVPEVHTDNTTGATLLHSLRGTGLRMAAATDHDVHGPAGTETHSSSSENIGRTTVICRLAPGRSLRIVKYLAYGWSSRRSMPALNDQVRAALTAARYTGWDGLLDEQRAYLDEFWAGADVEVEGDPQLQQAVRFGLFHVLQAGARAEGRAIPAKGLTGPGYDGHTFWDTETFVLPMLSHTVPDAAAHALRWRRETLPLALERAQQLGFEGAAFPWRTIRGQECSGYWPAGTAALHVNADIADAVLRHVGATGDDEFERTVGLELLTATARLWRSVGHHDGDGGFRIDGVTGPDEYSAIADNNLFTNLMAQRNLRGAADVCRRHPDEAAELGVGHEEIASWQDAADAMVLPFDAKRGVHAQSENFTEHALWDFGGTPPEKYPLLLHFPYLDLYRKQVVKQADLVLAMQLCPEAFSPEQKQRNFAYYEQITVRDSSLSAATQGVLAAETGHLGLAYEYLCETGMLDLHDLAGNTEHGLHLAALSGVWSGVVAGFGGLRHLAAGLSFAPRLPEELSRIAFMIRWRGRRLRVEVHPGEARYRLIDGADLELLHHGERLTVGKAEVTAGIPAFGPVEPVRQPVGREPLVRRLRAGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2M2</accession>
    <name>A0A010Z2M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2754"/>
    <dbReference type="HOGENOM" id="CLU_077407_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014541">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43224">
        <property type="entry name" value="PTHR43224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028188">
        <property type="entry name" value="Amdntrnsf_FN0238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="34121" checksum="700321717F347CB5" modified="2014-06-11" version="1">MSEVGQAPAAVIMVRPHHFVPNPATISDNLFQARSEVPPSRALADAALAEVTAVADALRGVGVGVHLFDDESTGTPDSVFPNNWFSTHPDGRVAIYPLYAPNRRAERRADIVQSLRVGFQVNGVHDYSVLEDDCLYLEGTGSMVLDHVGRVAYVARSFRSHDRAVAMVCRDLGYEPVVFSSLDSRGAPIYHTNVMMSVGSTVALVALDSFEHRAERDAVERRLAASGRAVVPLTQGQVDEFAGNAIELRGTGGSYLLLSARAYDSLTSEQRATLSAHVHLLPVAVPTIELAGGSVRCMVAGIHLPRRVRETGLAEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z373</accession>
    <name>A0A010Z373_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851317.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2944"/>
    <dbReference type="HOGENOM" id="CLU_133756_0_0_11"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="16147" checksum="E873411132D204AF" modified="2014-06-11" version="1">MATTPTDGFTAEERAAMKERTAELRAEGRKGAKKADGLQAVLDRVETMAPGDRALAERVHVVVTATAPQLTPKTWYGMPAYANEDGKIVLFFQDAGKFNYRYATLGFQDPANLDDGDLWPTSYALRAWTPVVEKQVVELVQRAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3Q8</accession>
    <name>A0A010Z3Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851551.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1737496_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="15769" checksum="2D44689049CBABD6" modified="2014-06-11" version="1">MRRLYEQPAGLVAARLLLTQLVASGTFPHRESYEPEEVAAAWAVSELSSRGARAAAGRGFDRPYRGKPADAVYPELIPAGGAARAAAVAEHDALCRQLRDHLAAGGIASGELFDVAVDLTWCDRAGGKVIAEIKSCLAGMNADRLLLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3T3</accession>
    <name>A0A010Z3T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, sigma-B/F/G subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570298.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3142"/>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="30172" checksum="483421AD5457D5DA" modified="2014-06-11" version="1">MTIAPIAPSEGDTEDPDYSDHSAVAPLFRRFAALTDVSSEKALLRERLILIHLPLAEHLAQRFSRRGEPVDDLVQVARLGLLKAVDRFDPRRDVPFLGFAVPTIAGEIRRYFRDHAWYVRPPRRLQELHLRLNTASTEMFQRDHRAPTARTLAEHLGLPTDEVHEGLQLTNSYAPLPLDAPSSAGSDGPSVIESLGALDEALALVDNREALKRLIADLPERERRILGLRFFDERTQSQIASDIGVSQMQVSRLLSATLTRLRRQILADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3X4</accession>
    <name>A0A010Z3X4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851664.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3188"/>
    <dbReference type="HOGENOM" id="CLU_085376_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="25324" checksum="56008D44C92D1238" modified="2014-06-11" version="1">MTSDSAAEQAGASPLTGVGEQLRRARQAAGISVREMARRVDVSPSFISQVELGRTKPSVGTLYAIASELGVPLDDLMPIGQALPEPAAPPARPVPEGDDRLQLIRRGVLRPFDAEPENTGSEAPVQRADRRHELRMGSAVWGRLTADHDPDNDFLHVVYAPGGESCPADNMIHHRGHEYGYVIAGLLDVQVGFTHYTLHAGDSISFASTTPHRLSNPGGVDSVSLWMVVGRGGTPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z465</accession>
    <name>A0A010Z465_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060960_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="22430" checksum="3F907319C29903F2" modified="2014-06-11" version="1">MAKEMEGDNRKRRALARDARDEDKSPSASGVTLGSSKQREHTRRGRRDGPPPAGAHKPGPDAPVAHRPHGDTEPTPADEPGDRATPDEGSLRLRYREVVSAAAARAGVEFDDGKSAARATIAVLAGTLDADDRRRLVAALPAELTVGPRFPAPSPPAGEADFVRTVALLAGCAPEHAQRRVQAVFAAINDEDPDVLRALSVPAGIEELVLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4J1</accession>
    <name>A0A010Z4J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851949.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_1_0_11"/>
    <dbReference type="OrthoDB" id="228571at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="378" mass="41030" checksum="C595904F71C4A86D" modified="2014-06-11" version="1">MAGTTHYVKIDKTKTLAEEPLTGHNRWHEDIPPILTVDPGDTVVLDVRDAWDSQFDKDTTNDDVGRATTDLVHPHTGPVYVRDAEPGDLLEVRIGPTRCDRWGYTVQVPGFGFLRETYQAPHITKWDIADNWATSEQIPGVRIPGAPFMGSIGVAPSTSLRETYLRREAELLARGGAVKGPEPRGAVPADPAIADEALRTIPPREIAGNIDVKQLTAGTTMLIPVATEGALFSVADAHFAQGDGEVCGTAIEVAATFTAELRLRKGEARRRGVQGLQFFRDALATGHGTTEPAWSTPTRFYATTGLPIRADGTNESEDTSLAAANALHQMIAYLVDEWGYDEQQAYTICSVAVDLKISEMVDVPNFVVTAVLPLDIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4R4</accession>
    <name>A0A010Z4R4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852050.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3469"/>
    <dbReference type="HOGENOM" id="CLU_048587_0_0_11"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="32819" checksum="F6D3B8C25175AD39" modified="2014-06-11" version="1">MIQHLPIPRGPIELAGDLHLPDGGADVSAPLRAVVLSTPGSSVKEQIGANYASRLAAGGIAALTFDPAHQGESGGEPRDLEDPYRRSEDISYAIDALSTVPGVDPRRVGVLGICAGGGYAVHVARTDHRIRAVGTVDPGEIGASFRGFQSDGPVAALEALADARLEETRTGRLTRENWLPDTMADAETAGVTDVDLLQAIRYYRTGRGHHERSTNRRLSRGDSLLLGFDAYHLVDELLTQPLLLVLAEHLAGTGFDESGKRLWAMAPNPVDRLVIAGARHYEMYDVPEYVDAAAERLVGFYTEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5J4</accession>
    <name>A0A010Z5J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570610.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3782"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="31391" checksum="D1582E74356755AC" modified="2014-06-11" version="1">MDHARTGSTTREGRSIFGVALRAWRDRTDPATLGVDRHAARRVTGLRRGELATLAGISAEYVAQLEQGRGATPSAQVCLALARALQLSDTEQAHLLRLAGHVVGPDRVPRLIPASVRRVVDQLDAHPLSVHDATWQLLHWNPLFTAVWGDPSEAPAADRNAMIIQFEGLNPRVRQSAAERDWFERSLVADLRTTAGRYPGDPDVAALIERLDRTARFRELWARPVVAAHESAHKVAVHPEVGEIALDANILPIQDSDLRIVVLTARPGTDARGALDRLLSPPRRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6H8</accession>
    <name>A0A010Z6H8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline-quinone synthase</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pqqC</name>
        <name evidence="4" type="ORF">CryarDRAFT_4112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone</text>
            <dbReference type="Rhea" id="RHEA:10692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
            <dbReference type="ChEBI" id="CHEBI:58778"/>
            <dbReference type="EC" id="1.3.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852970.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4085"/>
    <dbReference type="HOGENOM" id="CLU_080136_0_0_11"/>
    <dbReference type="OrthoDB" id="1571811at2"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00654">
        <property type="entry name" value="PQQ_syn_PqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011845">
        <property type="entry name" value="PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02111">
        <property type="entry name" value="PQQ_syn_pqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="12"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="26079" checksum="F184293BEC9FD24B" modified="2014-06-11" version="1">MTAVLGTDFVATLRAHSQRYHHQHPFHVRMNAGELSPRQLRGWIANRFYYQENIPRKDAAILSNCPDVEVRRRWIRRVTDHDGTTGTEGGIEAWLRLGEAAGLPREEILDHRHLVPGVRFAVDAYVNFTRTRPWVEAVASSLTELFAPDLMAARLAAFERYYPWIEPEGLAYFRNRLHQAPRDCEHALEIVTTHCLSAESQAAAIDALSFKCDVLWSQLDCIDAAYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK37</accession>
    <name>A0A010ZK37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator of cell autolysis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.42"/>
    <dbReference type="HOGENOM" id="CLU_020473_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="277"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="41815" checksum="399A7AD24C910C9E" modified="2014-06-11" version="1">MSPTAGAVAAVVLVAVLLGVALVLRSRKRRVIATPTQRATYQVLHVASLAAPPLRSGLTEATAGKAIRPLHQLLGGAAVGLVAPDRVLAWDGPGEHHAPAVLKALEGTGRVVALHADDLLCDLLECPVRGAVVVPLSTGEDMAGALVAIVDTDPVPGLVRAAVETADWVSAQLAFAELDVSRERLAEAQLRALRAQISPHFIYNALSAISALVRTDPDRARELIEEFAEFVRYSVRAHGEYTTLAEELRSIDRYLLIERARFGERLQVRLQVAPEVLPVVVPYLCLQPLVENAVQHGLAGKAGTGTVSIIASDAGSECLISVEDDGVGMDPDQLKRTDDNRSAHVGLTNVDDRLRSVFGPGCGLVVETAPGAGTKVSMRVPKFQPGVRVVSGWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKV5</accession>
    <name>A0A010ZKV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847775.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.267"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_11"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="24755" checksum="3C6E5B6BA18B9F3C" modified="2014-06-11" version="1">MDEVLARSGLFQGVEPESAEALAAHLEYLDIPKGHTIFSEGELGDSLYIVMSGKIKVGRRAADGRENMIAVMGPSDLFGELSLFDPGPRTASAVAVTDAKVARMRQQSLRPWITNRPEIAEQLLRVLARRLRRTNDALADLIFTDVPGRVAKNLLQLAKRFGTREGSALRLTHDLTQEEIAQLVGASRETVNKALADFTSRGWLRLEGKSVVLLDPERLSRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKX6</accession>
    <name>A0A010ZKX6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gln_amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847814.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661771_0_0_11"/>
    <dbReference type="OrthoDB" id="261057at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028908">
        <property type="entry name" value="Tox-PL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15644">
        <property type="entry name" value="Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln_amidase" evidence="2">
        <location>
            <begin position="287"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="46025" checksum="A6FCA99E0535C949" modified="2014-06-11" version="1">MPPPVPPPDTLQRTQALESGRRRSDVELQVQAHRSGRDAIAAENRADELGRQAALARDHAYEARATWQWTAHRRTALAEELQQITAEANAVAGEQQKLSQQAQGAMRDIAAWDAWIAQQPEDGADEGQGQVGQLRDWLDRAEQRFRQLGAHLRTLADERDKRVSESVELAARQQSLVDQYQRLGSDAQRMDREAAACAAEAIGSRLDCREQLIDLVGLRPELCRWVNGAAVALVHDYEIPPGHRRPLQAEHNALEQALPSGTHPEPTTAWLSRLNGVGRRADQSRAQNCVDATLAFYDTYVRGRPRVAVPRIVDAHRSGTTRLPLRGEPSGRERLEKTLNGRLEKRETFEQIAAELEAKGHGAFAALVIGWADGTARTSAAVNHQNTILWVDPQLGLVSDKPVPAEWVRSLEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL10</accession>
    <name>A0A010ZL10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847881.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004329_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="34179" checksum="CAF8EADC69310CF4" modified="2014-06-11" version="1">MITLQPPPERDLPPGRHDTMRTEILRGIASERHRPSRGPRAFDVRRHFLPILAAAGVLAVICVSVGVIAVTRPDEKPEPAASLPPTSAPPRVVTPVPGFTDAQRSALRDSCVAATKTEKRDLPGRGDLPLARDHVRLDDMRLLNATSRRHSTVALLGNGSELVACSWGSKNYRPSMPPTGGFDYANFTEHAQWMPGVVARDHASSLDSGKEQYLQLMGRVNSEATKIQVVANPDTDKEASVTVDVVNRTYAVTLDYETYNEAAPHVRIRAIDANGKVVGEPGRDSDPRCYVDPNGTVVYGYGLKPPCAPAIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL61</accession>
    <name>A0A010ZL61_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_0424</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.408"/>
    <dbReference type="HOGENOM" id="CLU_014312_3_2_11"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="12">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="13">
        <location>
            <begin position="496"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG79389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="555" mass="57745" checksum="0939C5ACDF50CDA2" modified="2014-06-11" version="1">MDVQRRTAGAGNTIPRRLLTASPGWTVTADVCVIGSGVAGLCAALHAREAGLSVVVVTKVNIDDGSTRWAQGGIAAVLDPLDTPAAHARDTLVAGVGLCDPAAVDVLTREGPARLHELIAAGAEFDRNGDGSLMLTREGGHHANRIVHAGGDATGAEVQRALHAAIRRDEGIRLIEHALVLDLLTGADGRAAGVSLHVLGEGSEDGVGAVLARAVVLATGGLGQVFASTTNPAVSTGDGVALALRAGAVVTDLEFVQFHPTALYLGANAPAGQQPLVSEAMRGEGAYLRNADGERFMVGRHELAELAPRDIVAKNITREMLTAGSEHVWLDARHLGASFLEQRFPSILARARQAGIDPVTDLVPVAPAAHYASGGVRTDLHGRTSVPGLYACGEVACTGVHGANRLASNSLLEGLVFAGRIGSDLARDLPPQTEPADVEGSGLEHYVVSSTVREDLQHAMVRGAGVLRSASSLQSTSETLVQLGGKRSMDPRPVNWEVTNLHTVASALVAAASTREETRGCHWREDFPDASDDWRGHLLAAIAPDGALTETYEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN86</accession>
    <name>A0A010ZN86_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1194"/>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="124"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="405"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="589"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="681"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="898"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1228"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1445" mass="155388" checksum="89A7E6934D77A6C5" modified="2014-06-11" version="1">MTTAERGRRSRRPEELGSAPADNGGAQNGTMLAERPQIVRELTAALELLRKGDFSVRLPRRDGEDAELSELFNDVATRMDQRNREFERVSRVVGRDGRMTERVDESIGLGDWATGAQAINSLIDDLARPTTEVARVIDAVARGDLTQQMALEIAGQPLKGEFLRIGTTVNRMVDQLSSFADEVTRVAREVGTEGKLGGQAQVRGVSGVWRELTDNVNSMAGNLTGQVRNIAQVTTAVARGDLTQKITVDARGEILEVKSTVNTMVDQLSAFADEVTRVAREVGTEGKLGGQAHVRGVSGTWKELTENVNQLAQNLTGQVRNIAQVTTAVAKGDLTQKITVDARGEILELKDTVNTMVDQLSSFADEVTRVAGEVGTEGKLGGQAKVRGVSGTWQELTNNVNQLAGNLTGQVRNIAQVTTAVAKGDLTQKITVDARGEILELKNTVNTMVDQLSSFADEVTRVAREVGTDGKLGGQAQVRGVSGTWQELTDNVNQLAGNLTGQVRNIASVTTAVAKGDLTQKITVDAQGEILELKNTVNTMVDQLGSFADEVTRVAREVGTDGKLGGQAQVRGVSGTWRELTDNVNSMAGNLTSQVRNIAQVTTAVAKGDLGQKITVDAQGEILELKNTVNTMVDQLSSFANEVTRVAREVGTEGKLGGQAEVRDVSGTWRDLTQSVNILAGNLTTQVRAIAEVATAVTRGDLSQAIAVETQGELAELKDNINQMIGNLKDTTTKNAEQDWLKSNLARIGAQLQGQRDLRQVCQMIMSEITPVVDAQQGAFFLLEATREGLRLRLASSYGYAPRRGESVLSLGEGLVGQAAVERRSIRVEQTPAGYLTIGSGLGEAPPADLVIVPVLFEERVLGVIELASFKNFSDLHMSFLQQLVDTLGVVLNTIIANARTEELLAQSQRLTQELQAQSMELQRTNAELQEKAALLSEQNRNIEIKNREIEMARLGLEEKAEQLALSSQYKTEFMANMSHELRTPLNSLLVLARLLAENTESNLTGRQIEFARTIHDAGWDLLTLINDILDLSKVEAGKMDVHAGRVALDDVCGYVEQTFRAQSELKGLRFAVDRGPGVPEQLFTDEQRLQQILKNLLSNAVKFTDAGTVTLSIHVGPEDMLFASPTLNAADRVVAFAVTDTGIGVAADKLKLIFDPFQQADGSTSRKYGGTGLGLSISREIARVLGGSITVQSDVGRGSTFTLYLPERYPGEAAEPGSGLERLPEEDSQQIFSSSTYSGPLRSAPTSIVDAEDIGAAIITQGASSARPTPPELSAPVSYEEKPRPPAPMPRQVEPSRPPRGRTGPTVDTSVLAGRTVLIVDDDVRNVFALTSALELHGLTVLYADNGAAGIAMLQAHPEVDLVLMDVMMPDMDGNETTAAIRKMPGFSELPILFLTAKAMPGDRDKSLAAGASDYITKPVDLDRLLRLMAGWVTRDAGAPGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP52</accession>
    <name>A0A010ZP52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847350.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.20"/>
    <dbReference type="HOGENOM" id="CLU_1097186_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="26475" checksum="8EA8AAD908EB654E" modified="2014-06-11" version="1">MVFRRKKASTLDQASAKAKEIGAEVGAGVEHLRNAAVATAGAARDAVKPAVGSARDALGPKVDAARVAVAPKVEAARVAVAPKLESALGTARETVGPRVESARDTAVTAVKPKVDQVLVALAPLVAAAVEAQTTSKKQVKKSAKKFEKQTRGQRKEAAKRARETALALRGERRRRWPWMLGALAAGTAVGAGVALAARRNRRPEWEEYDLVEPDTRTTVKAKADQVAERVAGATDTATGTATDSKSAADSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP96</accession>
    <name>A0A010ZP96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.65"/>
    <dbReference type="HOGENOM" id="CLU_050048_0_0_11"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="184"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="348" mass="36726" checksum="867CCD63258FB010" modified="2014-06-11" version="1">MLGTHDWRMTLWQIRTVVDDEPGRLAALAGSLGELSVNILSVQVHPVVAGAVDDFVADAPASLTAEDLAAAVAAGGGRRAVVRPADVHGLADPPTRALQLAARLVRDPESLPLALSELLDGGAVEWSPAGVPVPDEGELQLRDPRGGSLRVVRMDSRLTPSEAARAHALADLATVLAAAPEGAVTWRRASAADVDEIAAMHDRCSDETRFRRYHSGLTRIPRRQLARLVNPRLGVALVGEVDGAIVAMGNLMWCGAADATPAELGLLVEDAWQSRGLGTAVTRRLLAAAVDAECDRIHAMVRPDNVPMLRLLAGLGLPTHRHWEDGTLTVTVDLAAKIDEGVASSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPB8</accession>
    <name>A0A010ZPB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29255" checksum="08610D1872AFE798" modified="2014-06-11" version="1">MTQTVEAPPRATTIWPFLALAFGIAWGWMALSCLVFDLSFANPLVQIPCGFAPAIAAVVVRRWISREGFADAGSRPRLRAAWPYYVLAWLVPFGIAAVVLVIAAASGKWDPALDEVVPGLPVWVLPLALGLLALVTTPLFWGEEFGWTGYLLVRIAPGRPRVAALAAGLVAAIWHYPLVLTDYDQYGNVLLGLVGWTAWIMCQEVLLAWLRERSGSVWPACLAHAGNNMILAPLIGVLITTGAFSNEVVNFLVVAVLIVLALRPLLTAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPN0</accession>
    <name>A0A010ZPN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein CryarDRAFT_0205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.192"/>
    <dbReference type="HOGENOM" id="CLU_140930_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="10038" checksum="03924DB6785584C5" modified="2014-06-11" version="1">MQAILAQAQQMQQHIMEAQAQLAEAEFTGVAGGGLVTATVTGTGELTGLAIQPAAVDPEDTETLADLVVAAVRAANAEAQKAAADSMGPLAGGLPGLPGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPV3</accession>
    <name>A0A010ZPV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847760.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.255"/>
    <dbReference type="HOGENOM" id="CLU_079430_2_0_11"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16443" checksum="D4D563CCCAC2E092" modified="2014-06-11" version="1">MSTTAGGLKNRLTTDLTTAMKAKDEIVTSTIRMALTAIRNEEVAGKAARELSEDEVLRVLTREAKKRVEAAEAFASGGRGDRAERERAEGEVLNRYLPAQLSDEELATVVAGALAEAGVSDVKQMGKAMKAVQTAVAGRAQGGRVAAEVKRQLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ52</accession>
    <name>A0A010ZQ52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725689.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1836"/>
    <dbReference type="HOGENOM" id="CLU_012494_10_1_11"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="26401" checksum="766F7659297B41D7" modified="2014-06-11" version="1">MSEPLPEGGRPGRPVAYGPGPEQVAEFYEVPDPAAVVLFLHGGYWRARYDRSHARPLATALADAGYAVLLAEYRRVGQPGGGYPGTLEDVATLVDTLPAAVAPGRPLILAGHSAGGQLALWAAARRSLPPGAPGAPLAPVAIAGVVALAPVADLRVGAELGLGDGAIEDFLGGSPGSVPERYAIADPTGLPRPAVPVTILHGEADDVVTPDVSRNYAADGRADLILIPGADHFGVITPGSREWPRVLTALSAQIYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQB0</accession>
    <name>A0A010ZQB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849968.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1913"/>
    <dbReference type="HOGENOM" id="CLU_091328_1_0_11"/>
    <dbReference type="OrthoDB" id="1936227at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="22605" checksum="CB41D37AE0FB482E" modified="2014-06-11" version="1">MSLLRRKSTPVSDEVPETVEPVSEPSGKAYTPGKGRPTPKRTANSRPRNVTAAAGPTDKKAMRAKMREERSKAYEGMRRGEEKYLSPRDKGPVRRLVRDLVDARRNVGSYFLVGALAVLLFSQPQWPSAVRFGANILWLLLIVAILADVFLISRLIRKNVRERFPNAPDKMGGLTFYGVMRSVQFRRMRTPGPQVKIGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQG9</accession>
    <name>A0A010ZQG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1984"/>
    <dbReference type="HOGENOM" id="CLU_042387_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="421" mass="45051" checksum="A3E510C0C80245AB" modified="2014-06-11" version="1">MGADHTEQPTLRPTTGSVDEPPAPVPLLVPRDGTPEPVDTADALAEAAARLAAASGPVAVDAERASGYRYGQRAYLVQLRRGGEKAGHTVLIDPLPFDDLAVVDAAIVDTEWVLHAASQDLPCLAELGLRPRKLFDTELAGRLAGFERVGLGAMTERVLGRTLEKGHSAADWSTRPLPVEWLTYAALDVELLVELRDALAAELERQGKQAWADEEFAALVASKPPAPRAEPWRRTSGIHRVRTARGLARVRALWEARDEIARRRDLAPGRVLPDSAIVAAAQADPADERALLSLPVYSGRATRRLAGTWLGALTSARALTQDELPTTATGGDGPPPAHRWADRDPAAATRLTRAKAVVSGLSTEHNVPAENLISPDTVRRLCWSPPDPGDLDGVEQALRTLGAREWQIGLVGPGLVEALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQV4</accession>
    <name>A0A010ZQV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1453430_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="18100" checksum="C8E0F45152119569" modified="2014-06-11" version="1">MRVAAAGVVVALSACAGGESYGSLPPPGPSSAPPASCGADEGAGACGEAVVAQYRRFWGEVLPAAAAAAPARRRAVLAPVTAEPELTHLVRSLALLDEKRQRNYGTDVVLEQTVRVDGPGAVVEGCLDSSRSGVADAVSGKALTRGVPRNPVRADLVREADRVWRVTAITYPPGATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRD0</accession>
    <name>A0A010ZRD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850424.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2277"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="22855" checksum="14484156B44640A9" modified="2014-06-11" version="1">MRVVIAEDLALLRDGLVRLFTAYDDTVVAAVSSGPELLDALVEHRPDVAVVDVRLPPTFTDEGLVAAIEARRRIPGLPVLVLSQYVAQLFARELLSDGAGAVGYLLKDRVGDVTRFVESVRAVAAGGTVMDPQVIAKLLARPTHAGALGRLTPREHEVLALMAQGRNNAAIAAALTVTEKAIQKHINAIFAKLDLTSADEHRRVRAVLTFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS72</accession>
    <name>A0A010ZS72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1108"/>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="277"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="528" mass="56844" checksum="A7116AF05FCB7C7F" modified="2014-06-11" version="1">MTVEPQVLAIDLGTSGMKAALVAADGTVTGWAEREVKLHVLPGGGAEQDPRDWWDALAEVVADLGRAHPDHLRAITTICSSTQGEGTIPVDAAGEALTRCITWLDMRGARNLKEHFKGFPAKDGVAVRRIPRWLRLTGGMPSTTGKDPAAHMLYVRDELPEVYERTASFLNVLDWINLKLTGRTVATVDSILTSWVTDNRKPDDIHYDAGLVAASGIDRDKFPPIVACTEVIGEISREAAAHLGLPLATQVVAGAIDNTAAAVGAGTVADNQPHLYIGTSSWIAAHVRRKKTDVFAQIASVPCAVPDRYLMTALQATAGANLTWLRDKIVEYDDPLVGAGHVSRDEGSIFDAFDRILPTVPAGANGVVYTPWLYGERAPVDDPKLRAGFFNISLDTNRSDLLRAVFEGVAFNTRWLSAAVNRFLGAPVSSLVITGGGARSDAWCQIFADVLGVEIRRDARPVAVNARGAGWIGAVGAGLVTFPEISGLAKNDHCFAPDDTKRALYDDLFASYRTLHKQLAPVYRRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS90</accession>
    <name>A0A010ZS90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1128"/>
    <dbReference type="HOGENOM" id="CLU_083287_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="19919" checksum="4774B7F969D11663" modified="2014-06-11" version="1">MMCQLFPGKVIGMTDPRWLDADEQRAWRRYLRMHAELTTRLARQLQSESDLSLADFEVLVNLTDVPEGRIRVTELAKSLQWEKSRLSHHFSRMEKRGLVVREDCPSDARGAFVVLTPHGRATIEAAAPGHVETVRSLMFDGLTDEQVDALESIADVVLDRIERADAGALRSAPPGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSC2</accession>
    <name>A0A010ZSC2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="14" type="ORF">CryarDRAFT_1182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569801.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1162"/>
    <dbReference type="HOGENOM" id="CLU_018272_3_0_11"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="13">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24127" checksum="C4B9E4C543604813" modified="2014-06-11" version="1">MNRGQRLADARLYLCTPDRPDLADFADAALAGGVDVIQLREKGIEARYELERLELLGAACRKHGALLAVNDRADVALAADADVLHLGQGDLPVPVARRIVGPDVLIGRSTHDPAQADAAAVQPGVDYFCTGPCWETPTKAGRPAAGLDLVRHVNSTERPWFAIGGIDEPRLDEVLEAGATRIVVVRAITEASDPKAAAQRLTARLRETAPTTSLRAHASGRGPENPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSD0</accession>
    <name>A0A010ZSD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">CryarDRAFT_1192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848917.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1172"/>
    <dbReference type="HOGENOM" id="CLU_052344_0_1_11"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29070" checksum="C36757984056D3EF" modified="2014-06-11" version="1">MTDAPIGIFDSGVGGLTVARAVLDQLPNEQLVYVGDTAHVPYGPRPIAQVRRFALEVLDHLVEQDVKMLVIACNSASAACLRDARERYRVPVVEVVLPAVRRAAAATRNGRVGVIGTRATITSGAYQDMFAAAPGVTVTGVACPEFVSFVERGVTSGRQLLGLAQAYLEPLQRAEVDTLVLGCTHYPLLTGVISLVMGDGVTLVSSADETAKDVYRALTEHDLLRGDDAGPPRHRFLATGDPEPFARLGRRFLGPEASVVSSLTLPAAASLEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSE9</accession>
    <name>A0A010ZSE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851017.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2699"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="25228" checksum="15CF46C39A2AE098" modified="2014-06-11" version="1">MSDQGLRIEEVSAGYSGLQILHGISLHVDAGELVSIVGANGAGKSTTLRLISGLLRASAGTVTYAGERIDGRRPHEIVRRGVVQVSEGRDLFGPMSVDENLRLGAWTVRSGVDELLDEVYALFPALAERRRQAAQTMSGGQQQMLAIGRALMSRPKLLMLDEPSTGLSPKLTWEVLEAVRSIRDRGVAVLLVEQNAAQALGISDRAYVLESGTIVLDGPGSALAEDARVRKAYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSJ8</accession>
    <name>A0A010ZSJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation enzyme/thioester reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2750"/>
    <dbReference type="HOGENOM" id="CLU_223141_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1093"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2120"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3538"/>
            <end position="3613"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4562"/>
            <end position="4636"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5089"/>
            <end position="5162"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1128"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2155"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3573"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="4597"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="5123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="5566" mass="590154" checksum="CF0C0CAB972BE1AA" modified="2014-06-11" version="1">[encoded data, 5566 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSQ1</accession>
    <name>A0A010ZSQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2805"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33113" checksum="6B944E3534397B8C" modified="2014-06-11" version="1">MATTTSDYYEVLGVERSASAEDIQRAYRKLARTYHPDVNSDPGAEDLFKRVNEANEVLSDAGLRARYDKFSPQFGDDWRKVPEDFEPGASGAPFGSGAGPGVYFSGGGADFEDLLGGLFGGGSGFFGGRPTGPVPGPDVEAEIELPVEDAYAGGRRSLTMRTATGVRTIEVNIPAGVVDGQRIRLAGQGGDGYGDDAPRGDLYLFVRLAPHPRYRVHGRDVTVELPVMPWEATLGATATVETPGGRVDVKVPAGSSSGRRLRLRGRGLPNPRGSAGDLYAEVKIVAPQRLTADQRAAWEALAATYATPGESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTG0</accession>
    <name>A0A010ZTG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851507.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177682_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="95" mass="10436" checksum="4F290E324C991742" modified="2014-06-11" version="1">MISEQPAPTRAEVDAWFTGVLDGSRTRDAADQWAATWLHSPTAIDDEVIWSAIGLLGGIDLESGPDGSLLHDDDQVRQWQSEFRRRCAASPTAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTP3</accession>
    <name>A0A010ZTP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849536.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="261" mass="26585" checksum="1AE8E4725C730EC8" modified="2014-06-11" version="1">MDLGLDGARAVVTGGSRGLGLAIADSLAREGAWVGLIARGPDDLADAAEKVGRHGRPVVTVVADVTDPAALEVAVNEVAESLGGLDRVVANAGGTQGNGNLRTGTVDDFLGTYALNVGHAAALTKASLPHLEAAGRGSVLFVASVTGMKPGPRTAYAAAKAAEIHLAATLALELAPLNVRVNAISPGSILFEGGGWAHLKANDPERFENFRANEFPFGRLGHPEEIGDVAAFLLSDRASWITGANIAVDGGQGRPSARSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU25</accession>
    <name>A0A010ZU25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3345</name>
        <name evidence="2" type="ORF">CryarDRAFT_3443</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2914763_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="61" mass="6796" checksum="ED0A506314448E1D" modified="2014-06-11" version="1">MLAGLCAFSDTVFNWRQVPMLLNDLQRLPDGVIPEPACAAIREFAATVEEGSHLYLWFVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUG7</accession>
    <name>A0A010ZUG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852019.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1515438_0_0_11"/>
    <dbReference type="OrthoDB" id="1906800at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19166" checksum="856F4C49260DE7B1" modified="2014-06-11" version="1">MDASIEQWTALAVLLPPAQAEDVVGFRMIGEQEAGVETLVEGLLEHGVPAADNVRAEIAVLAEVWGVRGRVEDALRRARPDPAGGTCVRLAPPVAAVDRQTPPVVVPWLECATCGGVLNRVVDGPFISDVDADRLELIDPDGTWGYEADELWEAFATLHECCDDPDCRLAPWLAWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUH6</accession>
    <name>A0A010ZUH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852038.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_1_1_11"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="58"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="29929" checksum="733C298831EA89B8" modified="2014-06-11" version="1">MSAVPADTTALDLGEITLTFVPDGELRADPAVAYPAGHEDIFTDGLDVVDEDGMLLLSIGAILVTAGTSRVLVDVGIGDRRIPLIRPGASRDGYMGGGALLRNLSALGVEPEQIDTILLTHLHADHVGWIGDGDATFPNAEYWVGEGEWQYWIRPENSGGPVGPRPNELEIIGSRRRRLVDGAEPVDGITAVDTAGHTPGHFGFAVRGTNACAFVVGDALHCPAEALRPDLAWVGDVDGGAAIRTRRNIAAHVRDTGAVLVGPHFPNAVFMEYSSSGLIPFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUL1</accession>
    <name>A0A010ZUL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852127.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3510"/>
    <dbReference type="HOGENOM" id="CLU_073327_1_0_11"/>
    <dbReference type="OrthoDB" id="1598464at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="27190" checksum="F66A10AEE3153677" modified="2014-06-11" version="1">MTTTKNVVLTATGQLFGDKDATAVDRWVSPDYVQHSSLAADGPEGIRGLVENLPDGFRYDLHRVVADGDLVALHGTYHGFGPDPLVAFDIFRVADGVLAEHWDALTPVVAETVSGRSQTDGPTEVTDLDQTDANRELVAGFVENVLKGGKVDLLTEYLSTESYAQHNVAIGDNLDGLGSALQALADQGIAMVYDTVHQVIAEGNFVLTVSEGRFGPTPTAFYDLFRVDAGRIVEHWDVTPEIPATLPHGNSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVD5</accession>
    <name>A0A010ZVD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850376.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2245"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="19850" checksum="109BF20D1075AD53" modified="2014-06-11" version="1">MARWEPGARERLVLAAVDLFTEQGYDATTVTQIAERAGVTKSTFFRHFPDKRELLVAGQDALSRLLAEGITEAPAGASPLQAVAAGLERASSMMGPMNRELGPRLKAAVAASAELQERDVLKQVGLATAMTEALAARGVPGPTAQLAGELGALAFKHGYARWSEADTESGLASYALAALDELRAASASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVE1</accession>
    <name>A0A010ZVE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861774.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2250"/>
    <dbReference type="HOGENOM" id="CLU_851683_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="34962" checksum="BB24F8D2D2A82B66" modified="2014-06-11" version="1">MRKALIVGIDNYQRLSPLSGCVRDAHAVAGVLRRNADGSPNFVEPRVVTAPAPSGTFSRARLRGAVENLFDGKPEIALFYFAGHGWIDDTGGFLCASDTTAGHDGLALTDVMTFAHRSDAQNKVIILDCCHAGVAGERALSRGLSEIATGMTVLTASTADQYSAETHSGGVFTTLLVDALQGAAANLIGAITPGSIYAHIDQSLGPWSQRPVFKTNVDNFVPLRTVVPPISVADLQALTTHFLTPDYRFPLDPSYEPERSTDQHSLPAPDPAHTAVFPVLQNYVKVNLVRPVDAPHMWHAAMGEKSCELTVLGKHYWRLVDKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVF9</accession>
    <name>A0A010ZVF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850410.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2265"/>
    <dbReference type="HOGENOM" id="CLU_037853_0_0_11"/>
    <dbReference type="OrthoDB" id="687646at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459246" evidence="1">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="395" mass="40960" checksum="2A151E011C05107C" modified="2014-06-11" version="1">MTIHRLLAAAVATLTLAACADATEPAAEATPGAAAGATPGAAAEATPHGYVAGAEELPEPRPALAYATRGADRLHLLDLTDETEKHVDLRIGAQRLVEDGRFVYVDAGDGRLEIVDAGVWTVDHSDHVHYYRAPARSLGVLTLDAPVTTIAGAGASTAISTTGGRVVVLDRRKLESGEIVERTTLPTAALAVPYADALLVATGGRVVATDARGRRTGDLAVPCAAPRGWAALRGGVVIACERSVVRVKQRGGKLTATTLPAPGAPLPSSGFTYRPRGNEAATTDGTGIWTVDAAKATLRRVPGRRDLTAVAPPADGATVLALATNGTVTSVDLNDGTVLATAAVRGASLTLDVDRAYLTEPRARAVHELDYRDGLRTARTLRVRERPDLAVEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWU3</accession>
    <name>A0A010ZWU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851116.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982521_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="28834" checksum="5D2678353F85BEB3" modified="2014-06-11" version="1">MRLARALVALAVRRSPAADREDDRREWEAELAVLAAEGRGGPALRYAASLALARPRGGPTLTWRGFRLIVIAPVVATVALFLGVVPTRLASAVLGADTQTSLMAVFAAGLAVAAGLLGRRWAVRVGTGWRILAVTVPGWAVGVLFNAGTASPASALQVHAPAFLVFFAGLAVALTLAGRLPRFGSAAGAAVALVAAHVATVVMMALSAVPLDFAYAPAWLFVSLTGFGVGGMPPGDALLVWDVTGFDTYLFVVFTGLAFGAVLRPPAGAAPSGSSRPAASGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX21</accession>
    <name>A0A010ZX21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851185.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2834"/>
    <dbReference type="HOGENOM" id="CLU_083287_3_0_11"/>
    <dbReference type="OrthoDB" id="1626703at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16470" checksum="2F8A520391E0E5A2" modified="2014-06-11" version="1">MTVASDPLALDRQVCFALVVASRTVNAIYRPLLEPMGLTHPQYLVMLALWERAPRSVRELSDVLQLDPGTLSPLLKRLESAGYVRRERDQRDERMLAVTLTGSGAALRARAELIPPAIVAELGMDLTELEQLHASLTRVIAAARTAQSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX73</accession>
    <name>A0A010ZX73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851261.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2899"/>
    <dbReference type="HOGENOM" id="CLU_069356_40_0_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="192" mass="19770" checksum="0C8C05A9DDC97CE5" modified="2014-06-11" version="1">MAYHHGNLRTDLLAAAEKALATVGVDGISLRSLARDLGVSHAAPSHHFRDKQALLDALAVEGFTRLADRVESTSPPDGSFRDRLDAMTRAYVGFAVEHEPLLALMLSTKHHPGATEALAAAAARGVVVAVDLVAAGQRAGEVRAGDPYTLAIVAAAQVHGVASMAARGLLGGVPLDVAISTTVDLVSRGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXA6</accession>
    <name>A0A010ZXA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with CBM13 carbohydrate-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570216.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2943"/>
    <dbReference type="HOGENOM" id="CLU_144043_0_0_11"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458110" evidence="1">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16002" checksum="5B83776E84A3E848" modified="2014-06-11" version="1">MKISTRCVVGGVLAGVAVAAAVPSAAVAGTYTTYRDLATGFCLDSNGEGRAYTLGCNGGSFQKWVLGSADGGVTLRNLATGFCLDSNTEGRVYTLGCNGGNYQVWTRTRHGSQVTLRNLATGFCLDSNTEGRAYTLGCNGGSYQRWTPATGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYM3</accession>
    <name>A0A010ZYM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400452_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="20426" checksum="4790244C5D626222" modified="2014-06-11" version="1">MAVAMGAAPSVARADDTNNRSFAGCPLLIERFSGDCVVKLQHYLNVVNPGYALAEDGKFGRLTRIAVLDFQGRNRLGADGNVGGITADALTAQYNAKQPPPPPANSPISCLAQGKVSDHKGNCVSDGVVGGGKPLGECLKEAAIDEATQKTLERAFTQGKFSSWKTALSTVKKISPFLTAAEAFKCGWWDRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A066</accession>
    <name>A0A011A066_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852893.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4048"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_11"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="42905" checksum="82EF97282D87260A" modified="2014-06-11" version="1">MTLPLTGLHVVDLCTYVAGPSACMTLAQLGADVVRIDPLGGATDTRRLPLAPGGQSLYWAGLNRGKRSIEVDLRGEGGRDVVRRLLGVPGEGHGILVTNAVGQSWLRHEELLAVRPDLIQIRIGGRADGRPAVDYTVNCEVGLPWVTGPVDASAPVNHVLPAGDLITGAHAALSVVSAERLRRATGAPQYVEINLADVAVATMAHLGFVADVVVNGSQRLREGNYLYGSYGCDFATVDARRVMVVALTNRHWNALIRLTGTADVLAAMEKALGVTFAEEEARYRYRDVISALLRPWFEQRTHAEVVASLETAKVLWGDYRTIEEMTRSSDGLLAASGLFTEVDDPALGRYPVPAPVGRPTGWTPPAPAPAPAVGADTGDVLTDWLGLPPAEIEALAADGAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0C6</accession>
    <name>A0A011A0C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type antimicrobial peptide transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853025.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4120"/>
    <dbReference type="HOGENOM" id="CLU_289828_0_0_11"/>
    <dbReference type="OrthoDB" id="1169719at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="903"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="953"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1039" mass="106115" checksum="5D7F393634944D6B" modified="2014-06-11" version="1">MTALLTRRARAQWALLLSLLTVLTLGATLLGTCTLLTTRTSERAVEVAASRADPAEVRATAYTVTIAAADARSVAADARTVLTDAMAPFAATTTTRASGVMQRIPAASDESRGLLSEAYLSGVDDLEDGATLVAGRWPRSGAGEAVLFDTTARLLGLEVGRTLRLGPQIGRQAARPVDLTVVGLVRPRPDAGWDRDPLGGEGFDPSPADVRYAPQVNAYGPVLVTLDDLLSGGPSLDRLEVTARPDLSAPTGRDLDRLSRSVLGVDRRLSGTVGDRVQYVRATSPIPDLLLDARRQQQLVAGSVLAFALIGVLLTAIALALAGRLATGVRAEEDALLTALGTGPGQLAVLAAIEAVVLAALAAVISVPASSLLHAALTHASPLTDAGLSTSPLVTFAQVAAVVAGALALAVLHVVLAVRRAPDSGDRRTRRELLARSGADVLLCVLAAVGWWQLRAQSAAADTRADVVRVLAPALVLVACVAVALRLLPPALRRAESLAARARGLVVPLAAFQAARRPQAFAAGLLIGLACAAATFGTAFGATWTASQHDQADLSVGTDLAVALTGPPAAGQTDRVRSATGGVVSPVAIRNVAVGQFLGGPGDAPRLVALDTRRADAVIRGRTGGQWSGLRPTSPATGPQLPEGATLTVTGTATDGPIVVTPHLVLEDSTGLRTACDGPPAPLDGRPHVVPGCAPVAGLRLVAVSLPVTGLPQRGALSAIEATVRLSGGDFPPAWRMGVASPGFGQVSGKSLVPSGPELRLKAIVNFTDPHEASRTLVLTGFPEPGPLPLAISERLARAVKASPGSTLNLSVGTTPVEAVVTRIVARVPSEPGAAAALADVDALSRVLIARGDAEPPVTAWWVGGPRAGAENAIAKLHIGDVTTRVAETERLSSGPLRASLPAVLHVLVAASVLLLLGGVVLHVAYDVQLRALEVARLRGLGVSRRDIRSTLLLEHAAVLLPVLAAGALVGAATTWAVAPLMIRSDAGAAPVPPVAGHWPWLGIGGLLALLVVGSGLAVAAVVTVQARRADAAHLRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0J5</accession>
    <name>A0A011A0J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853260.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4197"/>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_11"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="43334" checksum="10E02C30AD7AA237" modified="2014-06-11" version="1">MELTSGDFWGDDPHSALTWLRAHDPVHWDEAGGVWGLTRYADVKEASLHPELFSNAGGIRPETPATPMMIDQDDPAHLLRRRLISKGFTPRRIADLRPRIAEVSHALIDRVAGRGGCDFVRDIAAWLPLIVIGDLLGARPEHYDDLLRWSDDMMAVQGQRADPVRTARMAIALAEYREYFTAVLADRRANETDDLIGVLVRAEVDGARLDDETLYFDSLLLLIGGDETTRHVLSGGLYQLLADRTRWERLRADRSLLPGAIEESLRWVSPIRNMARTVTRDLTLHGRALKSGQKVLLLYPSANRDEEVFPDPFQFDVRRSPNPHLAFGIGTHFCLGSSLARLELEVLFTALLDRLPELRLAAPDEPALRPAIFVSGYERLPLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0K0</accession>
    <name>A0A011A0K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570725.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_13_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="21136" checksum="1958C516907FB65C" modified="2014-06-11" version="1">MTRWAGVSAEDRRAERREMLVRAGYRLFGAEADLTVRAVCREAQLHTRYFYENFADVGGLLGAVYDGQASALGDALQRAVASAGSGAEARTRAGVRGVLEFLRDDPRRGRLLFSSEVLASRRRVTETELLEGLIAMSGTPSTPVLVAATMFTGAMAELARQWADGRLGDDLDTVVDTAVTLATAMRTATTPAPAPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADK7</accession>
    <name>A0A011ADK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848924.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2733245_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7587" checksum="060A676A50683CF6" modified="2014-06-11" version="1">MSDGLRTVLYWLSAGMGVVGLALIVLALLQGAFRSRVQETTPWRVTSLAILLLAAGVTVAAIAFIWPHPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE31</accession>
    <name>A0A011AE31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">CryarDRAFT_1349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1325"/>
    <dbReference type="HOGENOM" id="CLU_064761_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="21492" checksum="2CB7A1CB10515850" modified="2014-06-11" version="1">MWVDCEMTGLELGHDALIEVAALVTDSDLNILGDGVDVVINAPDATLDGMLDVVREMHAKSGLTTEVRESTVTMAEAETLVLNYIKEHVPDPKSAPLCGNSIATDRGFLARDMPTLDNYLHYRMVDVSSIKELCRRWYPRVYFGQPAKGLAHRALADIKESIRELQYYRQAIFVPPPGPDVEQARAIAAGLPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEW6</accession>
    <name>A0A011AEW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849528.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1631"/>
    <dbReference type="HOGENOM" id="CLU_030671_0_0_11"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="33499" checksum="3E8EDD6A5531CA50" modified="2014-06-11" version="1">MTDVDSAIATMAAECRNWGRWGPDDVLGTLNHLDVDARQRAAALVRRGASFSLSMRFEADGPQKGWRRRTNPVHTMLDTGVDAVAGHQGFPHGIGGADDVIAMPLQCATQWDGLGHIFDRGKAWNGRPAEQVVSSLGDLVTGIEHMAADVAGRGVLLDVGREFGTDGVLPDGFAIGVDHLEQVASAQGVTVGRGDIVLVRTGQLGACRSLPGWGEFAGGAAPGLSFWTAPWLHRTEIAAIATDTWGFEVRPNEFPVAFQPLHQIAIPNIGLLIGEMWDLDALAADCAADGVYEFFLVAAPLPITGAVGSPVNPLALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFX3</accession>
    <name>A0A011AFX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887725_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="31763" checksum="894BE108E4845708" modified="2014-06-11" version="1">MSDPGYGNQNGPYPPGSPYPNDPRATPPQPAADPWAPPAASPFPATPGSGDEYAAPVSGAEYSVPGLNPQPVPPTSAPPNVPPGYAPPPVSVPPNPAPPNAGPPHSGPPNYAPTNYAAPNYAAPNYAPPPASAPPAGHPAGYGPAYATGPIPTSGYPTAPLPGAAEVGPSAVGRPPGGRNRLVVVLAAATAVLLVVGLTMSGLFIAKNGEQNDTQAKLTAAENTIKERDSKVSTLEKDLTDTKTKLTNTEQQLDGTKDSLGTANSDKQIIAKCLKLVIQALDAIGKRDKAKTDSLIAQLDAPCTKAEKLLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFZ4</accession>
    <name>A0A011AFZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850076.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2006"/>
    <dbReference type="HOGENOM" id="CLU_911409_0_0_11"/>
    <dbReference type="OrthoDB" id="1929417at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="33968" checksum="646A56606AEF779B" modified="2014-06-11" version="1">MYSLVSAPVLGFDLTRIEGGAGVSDVLTRALALTPDDLEVLAEHRADDGQRADLWAAIEIATTVQPTVRDVAGLSKADPDASVEKRASAALGLLQRAPLGTVDGLIQCVRYDVLDWTWSVTDGSEPDRAPQFPPVQRAGEPAPRPVKVQSEAASAATAVICDALVAGYLRAQLDDDTRRRLATPWVAASRRLPERETALGPTESSVRALLDRVGSLSQQDGSRLYKAAEAGRRDSASWAPAIHSASWAVHLAGRIREAAAAQFLLVQAVETSGIPITERAAGVWNLLSGAMQALAARDLVDAATAHRLLGPVLASLGPSALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGE4</accession>
    <name>A0A011AGE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850255.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2152"/>
    <dbReference type="HOGENOM" id="CLU_063235_0_0_11"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="252"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="35812" checksum="819A0CD010A798CF" modified="2014-06-11" version="1">MLRIELTADDLLRSRFALSPLFELNGLLRVLSGLSRHRLPSGLAARSRPVYRRLLAETDLAAVQALQWPRGGASFLVPPPASLAQSWDDELAALRAVPLDEARKDIAHCLRERPTDDPAVLAVLRADDVCERLAATLDRAWRELLAAEWLRLRAICERDVVHRAGLLGRAGWAAAFEDLHKHVRWHEGALELSRPGRGEVIRADGQGLLLVPSVFVWPAVAVHTDDPWPRALVYPARGTAALWQSAPVGPGALGDLLGPSRARVLTALDEPASTTQLAHALGLAVGAVGDHLAVLRRAGLADRARSGRSVLYRRTALGDALRAGAESTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHK8</accession>
    <name>A0A011AHK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570096.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2584"/>
    <dbReference type="HOGENOM" id="CLU_046982_0_0_11"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="36204" checksum="00E8F3117148FA81" modified="2014-06-11" version="1">MNVRDLLDALGDPGAPETFSAALGEPVLAIDVPDAASAAGLAMIVDPSRSVTDLRALPCVTVLVVPDPAVFAGAGHVPLILGDVLLTDDPDAPRPYVTPADGSAGGLAALRTTAAANPLAAAALALLLRSAEGLDVPAGLVSESATYSTLQAGAEFARWRAGRPPRPAGSDGDRVLVERAGDVLRVTMTRAARRNALDAAMRDALTEAFALAAADPAVTLELRGDGPDFCAGGDLDEFGTRPDPAVGHLTRLTRSPARLLHGVARRATAHLHGACLGAGIELPAFAGRVVAGPDTSIGLPEVSLGLVPGAGGTVSLPRRIGRQRTAWLGLSGRRLDATGALRWGLVDEVQGTIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHW6</accession>
    <name>A0A011AHW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2521971_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="84" mass="9199" checksum="A291005E8D4DDB2C" modified="2014-06-11" version="1">MSVLVVAAVAADRVLTVTGMPLPVYVAIVFGLTLVAPFGVRSWHLRHPDRCEHCRGRGSTTFVAARRLRTRMCSFCHGSGRMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AID1</accession>
    <name>A0A011AID1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative exporter of polyketide antibiotics</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851166.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2823"/>
    <dbReference type="HOGENOM" id="CLU_036785_2_0_11"/>
    <dbReference type="OrthoDB" id="1885421at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="53281" checksum="51137A972F784247" modified="2014-06-11" version="1">MFAGTATLVRLGLRLDRVRLPIWVLVLAVMPAATAAQYQGLYPTDADIRDVSGILANPALEAINGALFSVTLGGLTAWKIGATEFVLVALMSLLTVVRHTRAEEETGRLELVGSAATGRYAPLTAALLVAAIADVAAGVLVAALLAATGLPVAGSVAFGLATTVTGLLFAGVAAVAAQLVGAGRSATGIAAGVLGAAYLARALGDTGPTWLSWASPIGWAMRTRAFADERWWVPVLTLAVTSGLVVLAYALVERRDVGASLVPERPAPGSGSLGSPFALAWRLQRGVLLGWIVAMVFAGAVLGGSADGLSDSLESNANITDVLARLGGDAGIVDAYLAAVFGIMGLTIAAYTVQATLRMRTEEASQRVEPLLATPVGRLRWALGHLAFAVLGTPLLLAVAGLAGGVTYGLETADVSGQVPRLLAAALVQTPAAWVLAGFGVALFGLVPRWSVLAWGGLIACVLALELGALLGLSQWLIDVSPFAHVPKLPGDSLRTAPLVGLTVVAAALAAAGLAGFRRRDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIG6</accession>
    <name>A0A011AIG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713131_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="41035" checksum="E3B9E67B2635B264" modified="2014-06-11" version="1">MTDMEIQLRGAMDDLAEDAPSAEGLLSAVHRRGRADRRRRLIVGAVAVLAAGVLGGTSIVAVAERSDEQQVQTLQVAMPAGSSRSAPPSPVSTGWLPKGFPEPTVRLLGPNAWGLDTRRDEGMAALQVQIMPAKPVVRTKPGTLLTLAQGGVEYSLYWVPTHAPGAPPYGNTPPEAEGPYGELIFERQPGQWIRIIVQNSAGDVDLGITQSDLIRIATGLRDEPRTLPDAIELGLLPGNVVWGQLKNEDYGVYAGFVDADAPARPVDQNEQPNGHNGSVASQVAVSVVPQDSLDISEFAPPLSPLPEEDPDGDGSFGTTRRPSPPVVAEDGSVYRRDGSTTVLYRLASNPKLLVVVRVKDGVMSGAELLKVARSVRLGPDAAVKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIL7</accession>
    <name>A0A011AIL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725713.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093862_0_0_11"/>
    <dbReference type="OrthoDB" id="1407370at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458539" evidence="2">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="210" mass="22013" checksum="C891547B4E21D420" modified="2014-06-11" version="1">MRLLAPAGAACVCVSLVLFGVLHLVPPSAELDWSRRTISQYALLPNGWLFDAATLLLAAGSLAVVAALHRAGLLTRGAGVALLLWVVGLVGVVWFEKHDWSVGPSVDGDIHRVASLLAFLSLPAGALLAAAPRLRHSDAARLVAVGGAVSFLCFTPILWALVSEPWTGVRWWRAIPLGGVERLLGLAEVATVLLLAGWAARSAPSRADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJC0</accession>
    <name>A0A011AJC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570338.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3215"/>
    <dbReference type="HOGENOM" id="CLU_010194_17_2_11"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="25907" checksum="3E84F52F9B49E798" modified="2014-06-11" version="1">MSRTIAVFGAGTGLGSAIARRFAREGYRVALVARRPAPLDDLVRELAAGGVEAYAFPADLTATADVPALLAAVEEKLGPIDVVEYAPITTAPFTPAAELTPEALQRYLDLYVFTPMAIVRSVVPGMIARGDGAILVTHGASAVEPMPGMSGVGPAMAAARNYLASLHGELADHGVYVGTINVNALVRGSAGHRAITSGELPVALPPGVELPSIAPEELADAYWEMVAHRRRFEATIPALVGVTFSSAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJF7</accession>
    <name>A0A011AJF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570353.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3251"/>
    <dbReference type="HOGENOM" id="CLU_404260_0_0_11"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="226"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="680" mass="70599" checksum="88669EDC8D335F5A" modified="2014-06-11" version="1">MTTPADEAAGVLHASRKETERPRRYGVSRAVTGAPVTRTPRRPGPAPELLRVRWVEVRGSGAGFPAGFRTGFVTAAGALPEPAGGRVPDLVVVETDESCDASGVCARVLGPLRAFLSDRRYTGSRLAVVTRLGVAVEPGAPVNVAVAAAWGLVRAAQNEHPGRVVLVDVEADEPALLSVLAAVTATGEAQAAVRGGSVLVPRLEALDDGGGLLPPPGATPWRLTRGGDGLTLLPCPQVGAPLTGRQVRISVRAGGVNPSDASGRFRNLGREAAGIVLDVGPEVAGLRPGDRVTGLADACFGPVALSSEPLLLPVPEDWTFEQAATVPVAFLTAYYALADVAPGASVLVRDGAGGAGTAAIQLAQHLGADVYVTAAESTWDVLRDLGLPDDRIAVRWPTTRFDVVFENRYFDAGPDIVSAMLAELAELFAAGVLDPLPVTAFDVRRARDALWHLSRGEHTGKVVLTIPHGWDTDRTVLVTGGTGHLGRDIARYLVTARGTRRLVLAGPAAPGTDALRRELTASGARVDVVVCDVADRRALSALLTTHPVDAVVHVAGPLDGGAVGSLTPDELGSALRAKLDVAWHLHELVGDAPLVVLSSPAGLLGTPGRGADAAASAGLDALMHQRQRLGLPGLSLAWESGETALRLFDLAIGSDEALIAPFRVDAWADLPVPPLFDRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJW8</accession>
    <name>A0A011AJW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459505" evidence="1">
        <location>
            <begin position="37"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="28662" checksum="EE8F8F89D2E2D7E2" modified="2014-06-11" version="1">MLEHHRPSPSRRARRSIVAVAVAALLATAFASPAAAQSPGPKSKPTIVLVHGAWADGASWARVTERLQAQGYPVLAVPNPLRGLSSDAAYLGAFLKDHTSGPVVLVGHSYGGAVITSAAASDPDVEALVYVNAFVPDRGESLLGLLSSEGPVDTSIFEAVAYPGGSGDVDLYVKASVFPSAFANDLSPATAKQLAAAQRPITRSALGEQAGAPAWKSLPSWYLLGTADHIISPSLQEKMAERAKSKITKVNASHLSMISQPRAVEAVITAAARSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJZ6</accession>
    <name>A0A011AJZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851972.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3411"/>
    <dbReference type="HOGENOM" id="CLU_033610_0_0_11"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="481" mass="52216" checksum="C32905311DA8D787" modified="2014-06-11" version="1">MVSIPHTGGSHSSVVDLFPIKHLAAPEVRELPEPPATFRHVIGPGIVAAGVGMASGEFILFPYIASQVGLVFVWAAFVGLATQYFLNMEIERYTLATGETALTGFSRYWRHWGLLFAIMAYFANLWPGWATSSATLITYLVGGNRVPIAVGILFLIGIVLTMTPVVYQALEKIEMVKVAAILLLIVVGGVAAIGATAWADSPRIITEAGVPHQELGFALLLGALAFAGAGGGQNLCQSNWIRDKGFGMGAYVPRIVSPVTGQPEAAPSTGFVFEPTRENLDRWRRWWRFANLEQLSTFVLISFLTIFFTSLLAYATVFGREGLSSDISFLKVEGDALNESVGGWFGTFFWIIGALSLFAAALGIVDYTSRLGADVLKTAYLKSTNESKIYFGLVWGLVGIGVIVLLSGLTQPLILLVISAVTGGLMMFFYSALLLLINRRVLPREIRPSAVRVVALIWAFVLFGFLSALTFNEQIRKLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL50</accession>
    <name>A0A011AL50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852614.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3844"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21037" checksum="332D868E8C37FB8A" modified="2014-06-11" version="1">MVRVLLAEDVRILREALVAVLNLADDITVVEAVETGDAVVPAALRSHPDVAVLDIEMPGLDGISAAALLCQWLPACRTLILTGVARPGTLHRAQAAGVAGFMVKESRPEDLIDAVRTVAAGGRVIDPQLAFAALGATASPLTERERDVLRFTASGAELVEVASALNLSSGTVRNYLATAVTKLGARNRVDAIRIATEAGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALL2</accession>
    <name>A0A011ALL2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_4007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3981"/>
    <dbReference type="HOGENOM" id="CLU_000288_135_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="10">
        <location>
            <begin position="494"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="616" mass="62795" checksum="B8D22F2351598C49" modified="2014-06-11" version="1">MDANVCDVVTPLLPSDPQLIGRYSIQGRLGSGGMGIVYLGQSPGGRPAAIKVINERFGINSDSLARFRREVEVLRTVRSAYTAALIDCQLEQPPYWFATEYVPGPTLADAIAQRGPLPPDGGYRLLAALAEGLTDIHQHGICHRDIKPQNVILASTGPQLIDFGIARGTEHVALTQVGAAIGSPGYAAPEVLSRNEVAPPADVFALGATTTFAVTGRKPFGDGTGAVIMMRSMSGEIDLSGVEPRLAELLRACVAVEPGYRPTPEQIIETCRAQIPAFQPVDAGAVTAVTSAPPAPGGPPAPTTAPTYPTPFSGTATAPTVGGAPAAPTEVVSAVPAPPRPPVSGAPHSGAPHSAAPHSAAPHSGPPAFGAPPAFGAPPAFGGPHGVPPSFGPPNGPGVPNGPGAPNGPGPRRGRVALIVGAAVLALVVLLGGGAFAFSVLGSDEDTTTKAAVPGPSAAVPTPSATASAAASPAAPDSPDPATPAASESPDPAGAATVTWVDKATSRCLDGNAEGNVYTFPCNDGDYQKWIPKEVDGGFTFTSKATGLCLDSNPARNVYAMPCNEGDYQVWSVTENGDSFFNLTDKATGFVLDSNGDGQVYAFDANDGDYQRWRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG47</accession>
    <name>A0A010YG47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847716.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.220"/>
    <dbReference type="HOGENOM" id="CLU_125060_0_0_11"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="13119" checksum="0763BA07BB321F36" modified="2014-06-11" version="1">MSDIEQLVTRYLKTWNETDAERRRAEIDAVWSDDALYTDPLAVAEGRDAIDATIGAVQSQFPGLVFRLAGPVDAHHEQARFQWELGPAGGEALVVGFDVAVFADGRVRRVYGFLDKVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGG6</accession>
    <name>A0A010YGG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PSP1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847898.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.348"/>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_11"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29181" checksum="DEAD0DCC0DDECD17" modified="2014-06-11" version="1">MGMLCAVTFARYGRLYYADPGAFAPAVGDHVLVSTDDGPEVAQCVWAPTWVSEETSGFPVLVGMASDSDLSRDKILRRKKAQGKVAAKRLIREHELPMKVVAVDHALDANRTTIYFTAPQRVDFRSLVRDLGATLSARVELRQLSPRDAAKAQGGIGSCGRDLCCSTFLTDFEPVTIKMAKDQDLPLNPMRISGACGRLMCCLKYEHPLYQAFSASAPAVGARVSTPSGDGRVVGRSVPSDSLAVRLDEDGSRCSCSRAEVCESRQAYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHS7</accession>
    <name>A0A010YHS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.855"/>
    <dbReference type="HOGENOM" id="CLU_023562_1_0_11"/>
    <dbReference type="OrthoDB" id="485527at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="146"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="461"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="660" mass="69264" checksum="413FA81392835FF6" modified="2014-06-11" version="1">MSIALPRTKALGRPNRGWSIVGILAVWLVGYAAFHGKQTLALAPADINGFHQSLNDLNGSVGANRNSNPLFLYFFNEIKVGIDQIVVFLQHLISQPVGDRPLPYVGWLGVVALATWAAWAFGNWRVSLLTLAGLLFVGAQGLWQESMDTLALTITAVLLSLLIGIPLGIWAGVSNRFNNVVTPVLDLMQTMPTFVYLAPLTLLFLIGPAAATIATLIYAVPPVIRLTAHGIREVPTDSVEAGESLGSTRGQLLRKVLLPMAKPSIVVGINQTIMAALSMVTIAALIDAPGLGQVVVRALQTLDVGTAFNAGLSIVVLAIVLDRVTTAASVRVEREAGPSKARRYGALGGGVAALIGVYLSYTYVWAAEFPDSPNIGSPIIRAATSVSDWCQLHLAGFTGGLKDGFTAAVLNPLEALLSGSPWWLVIAAITAFAYVLGTWRTAVLSLVLLVLIIGTGVWFDAMVTLAATLVATVVTTALGLAVGIWMGRSDRADAIIRPVLDAAQTMPAFVYLVPFLALFEASRFTAIVAAVVYAAPVCIKIIADAIRGVSPTTVEAATAVGSSPWQIITKVQVPMARRGITLAVNQGLIYVLAMVVVGGLVGAGALGYDVVAGFVQISLFGKGLAAGVAIVLLGVLLDRITRAAASERLPAPISPRTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI07</accession>
    <name>A0A010YI07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig I-set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.951"/>
    <dbReference type="HOGENOM" id="CLU_379802_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458102" evidence="1">
        <location>
            <begin position="29"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="2">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="2">
        <location>
            <begin position="240"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="2">
        <location>
            <begin position="538"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="IG" evidence="2">
        <location>
            <begin position="637"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="729" mass="72878" checksum="88D354029E516918" modified="2014-06-11" version="1">MHVRRALAFGLGLATAVALVGVPAPVWAAPPTITVQPTVEASPAGGNIELTVGATAPGGGSLNYQWLYELIKGSGVWLPVPNSLLGVGVSGANTDTLKLNGVLTALNAIGLKVQVTAAGESATSDPVGVVVGDPPTIGAVAQVESRAVSGGDVHLTATAAGASPLVYSWQVLKPAALLSRWTSLTNGSGVSGARTATLALSNLTADVAKNSYRLVVTNPVGVDISDPVKIDVGVAPTVTNPVDAAAAGGSATFNSTIAGNPVPSVKWQKRASVNDAWVDLTSDAGTVSLADNVSTVKLGKLTTSDNGSQVRVVASNSFNETATSQPATITVAGSKPTITDPANIITLGVGNLLSVNVTGDPAPAVTWQRKSPASGSSWEDLSGVGTLVPTGVSTWLASMPLSGLTSALSGYKFRAVARNAVDTVVSDSSTLVAGLLPTVTNPADKTASAGAASISVNVTGDPAPTVTWQRRLAGVNAAWEDLAGQGTVSAGVATLPLSSVTSALNGSRYRAVVKNTVGQVVSDAAQLFVGAAPDVSNPTSQTALLGTAMFSAIVTGDPVPTVRWQVLDTSSNARWTNVATGGLFVAGVATLTLTGLTKAQSGNKYRVVATNGIQPDATSDAAVLTVSGTPLSITNPASAVTSALNGSVTLSVAASGEPAPSVQWQSLAPTIGSTWTNLSNGAGVAGATTSQLTLSLLTALRNGYRYRAVATNGSETATSSSSLLTVNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIT0</accession>
    <name>A0A010YIT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein E (SpoIIE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569807.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1196"/>
    <dbReference type="HOGENOM" id="CLU_014270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="580"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="812" mass="84834" checksum="C7F31CCB5803D6EF" modified="2014-06-11" version="1">MRADGGDVATSGKHRPRWDSEAAQDERREVSQQMGHQMNSSVGSVVVSRRAPLPGDARSPALARALARDVVEECGLSSLSDEVALLTTELATNAVVHAGTAMHIEVVGDAAGITVRVTDGSRAVLGPSLPPPMLAEGGRGLHLVDSLASEWGVAYGRSGKSVWFRLDVDDPVVTRAGSGPPATVTPEPVVEPPEPAEPRWGLRREVGIGLGRKIRGRRNGAVGAGGVVVKANEPAVPPKQVRRPVAGRSAAVVPAAEAAGWLTYLTDRVVHELDSTELAQEILYRLGEVTGASFGVLWVDEGSGVRALASVGITEDPIDPPVRLWPDDPPRPRNADLLPPTQALADAGAGVALSVALPSSPPIRGRLELGMPAGSLFRSADAVFALLAAERLAVSLDAARLRDTEQNRRGDLAFLADASELLASSLDVDLTLALVAQLCVPRLGEWCVIHTLDDAGDPELVVAVHNDERGVPELEDAFLAPDGAVLRERIRAATVTHAATPLTGPLSGLVLPLTARREVVGTMSIGDPPGRRHTSEEVAIAVDLARRAALSVDNARLYSERDSVAEALQSALLPASLPVADGLEFAAQYRPAGASNEVGGDFYDVLPLGDERWLLAIGDVCGKGPQAASVTGMVRDVLRTLAREGRDLPYALSALNRALVEEASLVREGNGPIDGQTVFCTVAAAFAERREGGLRVRLCLAGHPSPIAVRARGGAEPVGVGGMAAGLTDHIEVEEVSVDLGPGDALVFYTDGVTERRRGDAQFGEEGVLEVLSRSSGLSAADIAAGLRTAATDFGDGPLRDDLAILALRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJW1</accession>
    <name>A0A010YJW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="343"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="474" mass="50060" checksum="7DD3C83338449C73" modified="2014-06-11" version="1">MPLFAAACGVPSAIAPGNAWAHGCYLLGFASFVALGWVRLRTISGPARTGYGLILGALSVWLAGDLLYDALSRFVGPPGEVSASDVFWVSGYPLLAIGLVHLVRLRTSGRLREGLLDAMTLATVMAWLCWQFVILPAAENQRLALPVVVGALYPLGDVVLFAVVAILVLAPGSRGGPTRFVVGALTLTLLGDVLISMLPAVFEDLTRAVQADRLDGVLLVANSLFVSAVVHPNAAKIAEPAPAEHQKLHPARVVFLGIPLVTMPLFAGLNSFTGVVSRASLVVSIVLLTSLVLVRFVLVVRGQEAIRAELAHQAHHDQLTGLANRPALRTVLDLSLSAPRDAYGPVLFYLDLNGFKQINDRYGHAAGDVVLVEFARRLTGVLRHGDVAARLGGDEFVVLSDCVETPAEAGAMAGRLQALTVAPVVMDGERLTVGVSIGVAAADDLEHPDVDGLLAAADADMYRQKTARRSLQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMM0</accession>
    <name>A0A010YMM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycofactocin system glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850805.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028391_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023981">
        <property type="entry name" value="MftF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF6">
        <property type="entry name" value="PTHR43646:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03965">
        <property type="entry name" value="mycofact_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="89"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="469" mass="49144" checksum="B5E0893F690B4BC3" modified="2014-06-11" version="1">MSGRELAPAGIRLRLDEALRISPDGRTLLGGSPGRLLRVAEAAVPLIREWRDGAAVGAADSHRALARRLLDAGMAHPVWAPAENVEDVTVVVPTYARPVELARCLEAVRRTAPGVPVLVVDDGSPADAGIAGIAARFGARLVSHAGNRGPSAARNTGLAAVETPFAALVDSDVVVPDGWLHALRPYFGDEKAAAVAPRVTGHGDGSGWLGEYESAHSPLDMGASPGLVRAGALVPYVPTATLLVRMDAVRGRTFDTDLPIGEDVDFEWQLVDAGWNVHYVPSVTIGHEHRTRLRPFVARRRLYARSIGLLERRHPGSLPAARVSPALAATALALATRRPVVAAAAAAVGVGLLARQLRPVVPDPVTEAAGLVANGLPVTAMGLARAVGRVWWPLAVPAAVAVPRLRAPLVAALAAPVLSDWWNAGRRPRLDRFLAARLLDDVVSTAGTWEGSLRAGTAGPLLPAGTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN08</accession>
    <name>A0A010YN08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486714_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457894" evidence="1">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="20297" checksum="58F0E1CF62922722" modified="2014-06-11" version="1">MRLHHKTGIICALVVGLLTPAVPSAAIDRPAFNRYSAAQLAQQILALRAAGRIRIYDYSAHKAADRRDRSLASQQLADIAAGKRANLSRRCHRGRLVKIRPDIRILRFLADLGMSYGGYTINVLFGQCHSRRSLHYAGRAVDLRCGLRITRADTKAITWGVKRNLETCRRNAHWHYSVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNA2</accession>
    <name>A0A010YNA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type enterobactin transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2746"/>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="347" mass="34863" checksum="29DCE598CFAD07DD" modified="2014-06-11" version="1">MSLAAGRATYRAGPVSGVFSPRSLLASLALAVLAGLFFLLSVATGDLPLPLADIPVALVGAGDPATLFIVQELRLPRALVGLLVGVVFGLSGAVFQTMSRNPLAAPDMIGITGGAQVAVVGGIVLGWGSGLGTQVLGLLGAFAAGALVYVLSMGGGHGYRLVLVGIGVSWACASLTDYLLAKALPYQANEAVGWLFGSLNERGWHHVRPLVLSAAILVPVTLLLSRWLTTLQLGDAVARGLGTPVGAVRFALLIVGAGLAAFGTAAAGPIIFVALVSPQIAQRLAGTPAPPLVGSSLVGAALVLGADLVTRHVLVSVELPVGVVTGIVGAPVLLWLLTRTNRLGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNP0</accession>
    <name>A0A010YNP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme involved in inositol metabolism</fullName>
            <ecNumber evidence="2">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851205.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2852"/>
    <dbReference type="HOGENOM" id="CLU_066438_0_0_11"/>
    <dbReference type="OrthoDB" id="1047507at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="29728" checksum="77B7072018F75D57" modified="2014-06-11" version="1">MSTWFRPAGTAAADGYDVVVTPENAGWGYSSLRVLSVSRSLATGAEEMLVVPLDGGATVTVGEESFRLDGRADVFAGPTDFAYLPIGTTAQLAVEGRVALCGARTDVSLPFRYGPAGDVPVERRGAGSASRLVRNFGTVGVFETGALIACEVVTPDGNWSSYPAHKHDEATATESALEEIYYFEIAAGPAGEPGFGYHRTSSSAAGGIDVLAEVRDRDTALVPYGWHGPCIAAPGFDMYYLNVMAGPGAERAWLISDHPDHAWVRGTWAGQAIDPRLEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNP4</accession>
    <name>A0A010YNP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme/flavin dehydrogenase, mycofactocin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851214.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2857"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_11"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023989">
        <property type="entry name" value="MftD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03966">
        <property type="entry name" value="actino_HemFlav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="42494" checksum="5E8BB3265C3654BE" modified="2014-06-11" version="1">MASTRDWFETVAEAQRRAKKRLPKPVYLALLGGAEAGATMDDNVNAFRELGFRPRIADLPASRELSTTVMGQQIAFPVLISPTGVQAVDPDGEVAVAKAASQLGTAMGLSSFASKPIEEVIKENEKLFFQSYWVGSRDAMLARAERARAAGAKGLIVTLDWVFDSRRDWGSPFIPERINAEAVRKYAFPVAARPGYLYRWIRSGALPDLGVPNLVLPGEEVPTFFGAYGQWIQTPAPTWDDLQWLREQWGGPFMIKGITHPDDARRAVDIGATAISVSNHGGNNLDSTPATIRLLPAVADAVGDQIEVLLDGGIRRGSDVVKALALGARAVLIGRAYLWGMGANGEKGVNNVLVIIRDGISETLYGLGKSSIHHLTPDDLVIPADFTRSGTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP89</accession>
    <name>A0A010YP89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570274.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2301120_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="10798" checksum="6E5FFAE9C76A06A8" modified="2014-06-11" version="1">MSTRVDPAALLTASGAVDELGGTVRTHQTALESDTLGTGGAVPGFRTRHVLERLAYGWSDALNRHRDYLDELGTALADAATGYRRSDDDTAAEFRALDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPA9</accession>
    <name>A0A010YPA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851543.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285111_0_0_11"/>
    <dbReference type="OrthoDB" id="364033at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1152" mass="124026" checksum="F59507FBB148E891" modified="2014-06-11" version="1">MDGGGTSSIGATPRRVGAQELLEIRDAQWSPRLSAVSLVCEAEPDPAQCTEILRALGKLYRNRRVKGIDPTEYLLRYRHALVVGTAGFAITGYRRGTFWPAFWEAVGYRGDTEDRACWSLAFIEALRRLGLPTFDELVEQGAFPYLTRILMHTGIPDYCLPDFFGLVAERRRIAHVSPEEFVDWAAQRAAIDRLADVDVPVGRFLRFGGSYAVDLVDRVYDLLDRLVDGLDDSTTLLPARFGVQARQWWETADRPESGDRRPSRSDAGRRPRVILDPYGEGVVLRLPPLNDLGRAALWHLTTEDTNETVRSTEGGAVAAPTDYSLSRPVSDLMITLGDSSLSYQLPIVDRSWPMLAFDSDGRRLSATVPLPRSDVWILHPEEGQTDVLLVEGDARSIAEAPLPYGWFGWRLRYLDLTDVQALGLRDRARRWSVATTAAAQIQVGPSVRGVRSASGGPVHRSLPTIVLPPGAESLIWEIEVRSDDGDVPLAHVTTSGGDDPNVIWHRLPRPVLGTFVIHVRGPLGRSARRVVTIAEDLSMTASPSRRLMTRSGLVPVDVRVEGARGLTVSPARLRLPADETSAQVSAHAPGASATLSITPAHMAVAHDHGRLTVRWRTSPLDLVAEDMTGQPGSLLVTVGPDATGPVLLARAVSGEILQTLAPKGPLRGGTARFALAELGDTVGRHGHLRLEFSPDGLTEPTTVSLCALVRPRRLADDLTREGGVLRFGRFAAGVGLTAGVYAPLAPWWGVTPLPVRDGQVDLPPRLATCGPLRVVVRIDDPWAPDGWPSWPRPGDDTFTLAGVGHPEGDDDERTLAAFLGGASELPSATTRPELFWTALVLLPDLVPRHRLAAAAEQIGVVLSARPGSSLLALVSAEFEREAKIVALIRSGLPSAAVETDDLLAVAAAWTSLPPAAALLSGRRLVGSAGVEGGEVLELRHAARERCGAGLESVLSGAGDPSAATGRPGASEEQMAHFSPEQLRQLRRAVALVPRGLLDTDTRAEAALALFDARGAAPLASHLHGVTRLVREIKAFFSTRTGDPAPLEALRARLPAERMDGWRGLPAFSLGAALTARAAGSGDRDAGRLAERHRPLWVALAQVAPDLVALDLVLAEALRVRKRSELSARPVPRPPGSWRAPRAVPSPRSGDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPB4</accession>
    <name>A0A010YPB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045823_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4379" evidence="2">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4379" evidence="2">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4379" evidence="2">
        <location>
            <begin position="173"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4379" evidence="2">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4379" evidence="2">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="530" mass="59224" checksum="D76BE2A98F2EC6F1" modified="2014-06-11" version="1">MTDGRNRVPPRPRAPRPGHSITDTHPAMAAEWHPTRNGTVGPTDVSFGSTYECWWQCQADPTHEWRAQPNARWQGNRLLGCPWCSRRRATPERSLAVHHPDLAAEWHPDFNGNLTPFDRAPTSEFLAWWTCPEGHTYSATIGARVRRHTRPDRMTPARRLGCPTCRSLAGQRPDIAVEWHPEKNFDHPTEVAPRSGQERWWLCPIGHSYAATVANRTRVNPPGSGCPYCSGRRPTPTDTVIVTHPHLVTEFDNDINEEFFLDKVSAGSGRRAAWRCRRGHRWSATVRDRANDGTGCPECAGKRAGADNCLATLMPALTAEWHPELNGDRTPHTVTAFSDIHAVWRCTAGHVWSARIAHRSRGAGCPTCSIGNISRIEQALAASLAETLTVQTQVAIPIEGTARPVRADIVLPDLNIVIEYDGWYWHQDTVARDRARYEQLATRGYRLIRLREEPLGLLHRDDMVVPDRITNTSDRETAGRRVATLLLDHLARLELSHTPVQMPRAVSEAPGESATVSLVQTAGHCRVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPQ2</accession>
    <name>A0A010YPQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3267"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="34774" checksum="1161A5AD5F336C4F" modified="2014-06-11" version="1">MAPSRDFYATLGVARDVSADDMQRAYRKLARTYHPDVNKDPGAEERFKDISEAYDVLSDPEQRHRYDAFGPDFRDVPPDVDPQARARAGADGGRTRGSRGERGGRARRGGGPPEDVYTRSGGFQDIDFESMFGGVFGGRSDGGFGPIPGADQEAEIELTVEEAHTGGRRTVTLSGPDGSRTLNVTIPPGVTDGQRIRLSGQGGRGGDGATDGDLYLVVRLAPHPRYRVAGRDITATLPLTPWEAALGASVAVETPAGEARVRVPAGTPSGRRLRLAGRGLPNPRGRPGDLYAEARIMVPPEPSDEERRLFEQLAAVSTFDPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQR7</accession>
    <name>A0A010YQR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852416.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210195_0_0_11"/>
    <dbReference type="OrthoDB" id="1198550at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="7253" checksum="22D129CA138403FE" modified="2014-06-11" version="1">MINTVVKLADRLLSVVVPRTTALAEMEYRCVHCYGSFYRQDNRYCAGSCSEWYIGKCHDYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQT2</accession>
    <name>A0A010YQT2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_3757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570589.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3724"/>
    <dbReference type="HOGENOM" id="CLU_020309_0_0_11"/>
    <dbReference type="OrthoDB" id="49937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="11">
        <location>
            <begin position="413"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="774" mass="82532" checksum="2DC4E702AD5F01F4" modified="2014-06-11" version="1">MNQLRHDIDIDIDATTGTEVLDEISRKVLWLSTAIVDAANHGRPNTSGVKVGGHQASSASMVDIMVSLWFSELSRHDRVSVKPHASPVLHAINYLLGDLDPKYLTSLRAQGGLQSYPSRLKDPDTVDFSTGSVGIGATAAIWAAMAHRYVASHFDTAPKAGRFVSLLGDAELDEGAIWEAVADPSVARLGELLWIVDLNRQSLDRVVPDVQIHRLMGMFDAAGWQVITLKWGRAISALFERPGGDELRARLEAMPNEEYQRLLRVDTSLVADRIAGERGSAGLRALLASLPAAELAAAIRDLGGHDHGLLLDTYDSVESTRPTVIFAYTVKGRGLPTEGHPNNHSALLSEAQMATLAEAVGADPADPWRTFAPGSRAAELCGRRAAALERPPTPSRRPDVLPAALSRPHRKAISTQAALGRFMADLTREAPAAAARVVTCSPDVASSTNLGGWINKTGVWSAQDRPDWFADDTERVLKWSEVTTGQHIELGIAEVNLVGLLGELGATWSRWGERLIPIATLYDPFISRALEPWSYGIYAGGQSIIVGTPSGVTLAPEGGAHQSITTPSIGLEQPGCVAWEPAFAQDLEWCLLEAMNQVGVPGGTSGYFRLSTRPIDPGLAALPLDEVLRERRRRQAVAGGYRITAHSPADEQVTLVGAGAILPEVVAAAELLSSQGVTAGVVCLTSPDLVFRSAQGRGSDISAALFPAEHPAPLVTVLDGHPHTLSFLAGLRGDRTINLGVTEFGQSSGVDDAYRLHGIDVASIVDAALTLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRF4</accession>
    <name>A0A010YRF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250271_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="42" mass="4578" checksum="B82F2DE9D38136C2" modified="2014-06-11" version="1">MTTENAACGASAVFERSVRLAPEPRHRSMRLGTAAGKTTCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRM8</accession>
    <name>A0A010YRM8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570693.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4041"/>
    <dbReference type="HOGENOM" id="CLU_1178653_0_0_11"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="163"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="25351" checksum="7857C6E24BB6BA78" modified="2014-06-11" version="1">MADATFTALGQSLLAKVDVLAGELAARVRLAERELDVVPPEDLAAVCAEQLRTGWNRSRRRCARSTGRLLAVLPRPDGAAFPSLRGSRFGVSPPYQPLSQSAEALRLARLALAAVPPGTAGVCHYGERPIATVIADNPGTADDLARRVPGGLLELPADDRDALLRTARAWFDADGSTTRAAAAMFCHRNTVRYRLSRVEALTGRSVDRPREAAELLFALEAVALDLTRRHPGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVK0</accession>
    <name>A0A010YVK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847645.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191581_0_0_11"/>
    <dbReference type="OrthoDB" id="1920995at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="78" mass="8765" checksum="02EE2E1805C5BA02" modified="2014-06-11" version="1">MSTALVLALALIILTLGYLGLCRFWPYTHCRRCDGTGKRHALIGRGYRHCPRCGGTGERLRIGRHVLNHLTALHRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVP6</accession>
    <name>A0A010YVP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.223"/>
    <dbReference type="HOGENOM" id="CLU_038046_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="41512" checksum="A9488A422D4C52AA" modified="2014-06-11" version="1">MSANSRRTLVLGVAIALVAANLRPALAGVGPVLSDIRGDLGLSGVGASLLTSLPVICLGAIAAFAPALGRRWGSERVIALVVAVIAVSLALRVTDGRVVLFVGSIVAAGAIAIANVLIPAVIKRDFAGHTGTMTGIYTMSLSGAAAVAAGVTVPLSDATDQGWRGGLGFWAIPAAVAFGVWTLLVWLPARRNPTAAPPHRGGGSLLRDGLAWYITLYFGLQSLSFYSVLSWLPSIYRDEGYDPATAGLLLSISAFVQIPISLVLPPFAARARDQRLHTLACTVATLAGLTGVMIAPSGAPYLWVVLLGIGQGGSFGLGLLLFSLRTRTTAATARLSAQAQTVGYLLAATGPLLVGALHDVTDSWSVPVGLLIVLLIPQVVFGLLAGARRFVGAEVRETAETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW07</accession>
    <name>A0A010YW07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569596.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.331"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457712" evidence="1">
        <location>
            <begin position="35"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="429" mass="46469" checksum="0BB08F960D300B3A" modified="2014-06-11" version="1">MVTRRDLLRASGFGALAVAAAPLLAACGDGGSGASSSDLTLSYLGTADQQQVWNKLFAEFQRKNPDIKLKATGSPVDNWAAYFDKVSTQLAGGVRYDLIQVATEGMQLFAAKGLLQPLDDLVKANKTDLDDFLADAHPNLPKWNQQYGSPDGKTYFLPGDFNTMCLWFNKEVFQKAGVEAPTNEWTWDDFLKAGRTIKQKTGAFLYPATAEYFIGVMPWLLTNGASTLSDDWKKATCDTPAAIEAAEFARQLVAEKLSPPPGGSFDRFTLATQGKLATFGGGRWPIVNIRQANAVEKFGIVAWPKKVKQGSPVGWNGIPIMKNSNKPDQAFEFLKFLISKEGDAFFAQLGGTIVPARKSVAESTAYLDNSPTGTENLYAALDYATVIPAPAKGNLIQRDIEDTWGQILAGNTSPADGMKKMQEKVAANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWD2</accession>
    <name>A0A010YWD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic component of the Tol biopolymer transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848119.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917404_0_0_11"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458870" evidence="1">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="32396" checksum="50453847D295F4DE" modified="2014-06-11" version="1">MRRTIITGVVGAALALTVTSPALAAAQPATGSTWTAKTDWSLLVDNGRDMDRVVDGTTKTLLAGEAFQRKYGAYSADGRRIVYSDQGKTGFGAQIWTMNADGSHRRQLTSLTTEAFGPELSPNGTAIAFQTQGAIWVMKADGTAARKVSRDGYYYGTGISWAPDSAQFAVTRGLIDERSGEPYDIEVVTLRADGSRETALTRTGGDKNSPAWSPDGTTIVFSQSLAGENYDLWSMKADGTRVKQLTRTKDVGEQDTVWAPTGTAIAYAAWAQQTETAPRVMKAKADGTAAKSLGVVGYPTSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWK4</accession>
    <name>A0A010YWK4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848265.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.561"/>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_11"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="367" mass="39668" checksum="6692137F5A1974AA" modified="2014-06-11" version="1">MSDFKPGLEGVVAFHTEIAEPDRDGGALRYRGVNIEDLVGQVSFGNVWALLVDGKFGPGLPPAEPFPVPVHSGDIRVDVQAAIAMLAPYWGLKQLIDIGPEQAREDLARISVTALSFVAQSARGIGLPAVPQREIDKANTIVERFMIRWRGEPDPKHVQAVDAYFISAAEHGLNASTFTARVAAGTGADCAACISSAIGSMSGPLHGGAPSRVLKMLDEVEKSGDAEAWVKAALDKGERLMGFGHRVYRAEDPRAAVLRRTARELGSTRFEVAEALEKAALAELHARRPDRVLATNVEFWSAVVLDFAEVPAHMFTSMFSCARTAGWSAHVVEQKNLNKLVRPSALYTGPGPRKPDEVEGWDTIKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYC5</accession>
    <name>A0A010YYC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569825.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A010YYC5"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1259"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_1_11"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="559" mass="63349" checksum="1F17E1B689431582" modified="2014-06-11" version="1">MPEHWYREAVVYCCDVETFQDSNGDGVGDFPGLITRLDYLARLGITCLWLNPIHPTPNRDDGYDVADFYTVDPRLGTLGDFAELIHEAGNRGIRVIIDLVVNHTSNQHPWFKSAREDKDSPYRDWYIWSDTEPDDRREGMVFPGEQKETWTYDRTAKSWFYHRFYDFMPDLNTANPEVRAEIKRIAAFWLQLGVAGFRMDAAPFVIESTPDAPKDFAFLTDLRAHLQWRRGDAVILAEANVGADEVGQYFGDSGGSANRLHMLFDFALNARLMLALARGDAEPVIDALRDTPKLPESAQWATFLRNHDEVDLSKLTAEQRSDVFAEFGPDKDMQLYDRGIRRRMAPMLGNDRRRIELAYAMQFSLRGTPVIRYGEELGMGEDLSLHGRDAIRTPMQWSPSVNGGFSAGQELVRPVITEGEYGIGKINVVTQQQNPRSLLSWFERMIRTLRQCPEVGLGACSVIDVPMPRHVLAHQADQPERGAMVFLHNLSDEDVTVDLSALGNHAEQPYELLADRDYPSVDDTLSKIPLAGYGYRWIRLRDSRGRRTGGQVVTRGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYH5</accession>
    <name>A0A010YYH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xylose isomerase/AP endonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569833.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1287"/>
    <dbReference type="HOGENOM" id="CLU_041665_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40659" checksum="61D857D996D4FB33" modified="2014-06-11" version="1">MTDGPLSYCADIHPASDLGDVVAQLDRYAEPIRRSVPLERLGLGLRLPTFVAAGLASDRSARRRLRLELDARGLEVVTLNTGSESPRWNDPARLRYSIDCATVLADLLPDRFAYGTIGTVPLGWRTPWSVADDATAAAYLGLLVERLRALDGENGRPVTLAFEPAPGFRFDTVLDAVRWLAGRVDPEYVGVCVDTCALAVSFVDPAAAISAVYRAGLTVQKVQAATALQVDDPRDPATRRALTALTSDVAQPVRERGADGLTRAADDLPYALTWLPGAGPWRISRHLPLHARPDSPLRPTSGVLRATVDAVLAETGFADFPHVEIDVCPRAAGMDDVASLVAGVAADVACVSELLDEVGISSEPAARSLAGPMLRVGSAWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYY3</accession>
    <name>A0A010YYY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ORF">CryarDRAFT_1507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849309.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1480"/>
    <dbReference type="HOGENOM" id="CLU_050019_2_0_11"/>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="104"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="36873" checksum="FC112A8E47F4DBAF" modified="2014-06-11" version="1">MTLDERKLSVLRAIVQDYVNTEEPVGSKSLAERHQLGVSPATIRNDMAVLEEEGYIAQPHTSAGRIPTDKGYRLFVDRLAGIKPLSAAERRAIQTLLNGAIDLDDVVTRTVRLLAQLTRQVAVVQYPSLTRSSVRHVELVQLSVNRLLLVLITDTGRVDQRTVEFPSGISDDDVNVLRSAVNNALVGQRLSDAPTRVEELLDTIAPALRPALTTVASVLLETLVERREERVVLAGTANLTRSTVDFRGSVFPILEALEEQVVLLKLVGEVDSPSMLRVRIGDENQVEELRGISVVTTAYGAGDTALAGLGVVGPTRMDYPGTISAVRAVARYVGEILAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z079</accession>
    <name>A0A010Z079_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849971.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1917"/>
    <dbReference type="HOGENOM" id="CLU_027634_5_2_11"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="35179" checksum="7EA4EE476B502A15" modified="2014-06-11" version="1">MKIAVTGSIATDHLMHFPGRFATQLMPDQLDRVSLSFLVDDLVVRRGGVAANIAFGMGQLGLRGILVGAVGNDFADYRSWLERHGVDCDSVHVSEYAHTSRFVCTTDDDMCQIASFYAGAMSEARNIELGPIDERVGGLDLVLIGANDPEAMVRHTAECRQRGLRFAADPSQQLARMTGDQTRQLIDGAAFLFTNEYEKTLLENKTGYSEDELLDRVEIRVTTLGKDGVEIVGRGIERIHVECATEAAKADPTGVGDGFRAGFLTALSWGLELRRAAEVGNLLATYVLETVGTQEYSVDTTEFVKRLGGDYGDLAAEQVASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0C8</accession>
    <name>A0A010Z0C8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850036.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1968"/>
    <dbReference type="HOGENOM" id="CLU_055322_3_2_11"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="16699" checksum="4004DF78F399CDBB" modified="2014-06-11" version="1">MNVAVVAGNPKPQSRTLDAATRVARELTGQEPGSVVDVITLGAGLLGWGDAGVAAAVESVRSADVAVFASPTFKASYTGVLKLFLDQFATAEGLAGVVAVPVMLGAGPGHAMAPDLLLKPVLVELGASCPTPGLYLIDSTYTDSSAIADYAKRWSGAVAGTASGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1A6</accession>
    <name>A0A010Z1A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570036.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_11"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="29246" checksum="4104CB871E7CC8CB" modified="2014-06-11" version="1">MRTVLVTGASTGFGRVTAEALAQRGHHVFAGVRDVGGRNEKVAAELRSGGVTVVELDVLDQASADAAVAAVVEADGRLDAVINNAGRMFAGPVEAFTAAEIQTILDVNVLGPARVARAALPVLRRQGRGVLIQNGSLAGWVAMPYTGLYAASKAAVKALVETWHHELAPFGVESVTVDAAPYPTNIGANAGSPSELDRVAPYGTNFNGFLSDVMRRARSSEPGDPREVADAFVRLVEMPDGTRPRRTIVAPVSERDAVTAAATAADAATGAVATGMGVDSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1I7</accession>
    <name>A0A010Z1I7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850533.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2336"/>
    <dbReference type="HOGENOM" id="CLU_039483_4_1_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="26151" checksum="DD1269AB2C811B47" modified="2014-06-11" version="1">MIKTLVKTEFRLLLREPILLLWTTGLPIIAFTVLALVPGTSRPTDSLGGLSYAQVYLGVIALIALALLTTMSLPAVLGSYRERGILKRLSVTPMRPWRLLATQIGINLAVVLSTVAVMLIVATLTFDDGFPGNPLGWLITYLLAAGSLLGLAALVAALAPSSKVANAITSILFFPLMFFAGLWIPLQTMPGWLRTISEFTPLGAASQALATSIDGDFPAVKSLLVLLAYAVVFIGLAVRTFRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z248</accession>
    <name>A0A010Z248_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850835.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2576"/>
    <dbReference type="HOGENOM" id="CLU_056526_2_0_11"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="24425" checksum="DB68B7D4C999A4B7" modified="2014-06-11" version="1">MTAPHGHVDIAGYLFGLLDPVEFRRVEEHLATCAACRHEVTVLREIEDALDEVPPELFLDGPDPQADLLLQRTLRAARAESAGPRRSRGRSLVAGAAAVVALAAAVGGGVVLGRGGGSETPSVALPSESASVQGTRSGSNTDPATGARMTASVVPSTGWVRVNVKLTGIKVGEECEMVVHSTHSDPVLAGSWVISEKAASMPGGWPVTGNAAVAPEDVDAIEIRTTAGRHLVTVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z368</accession>
    <name>A0A010Z368_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851312.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2939"/>
    <dbReference type="HOGENOM" id="CLU_192336_0_0_11"/>
    <dbReference type="OrthoDB" id="1973287at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="68" mass="7627" checksum="4E3E9EBB4F08C414" modified="2014-06-11" version="1">MAEPVKGPASYFPSIEKKYGRPISEWQDLIRASPLTKHMELVNWLKAEHGLGHGHANALVAHVLADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z435</accession>
    <name>A0A010Z435_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851745.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3248"/>
    <dbReference type="HOGENOM" id="CLU_057759_1_0_11"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="33025" checksum="530145AEE6E0A4F2" modified="2014-06-11" version="1">MPAGTLYAISDLHVAYEENRQIVRDMRPTSASDWLIVAGDVGERFEDVRWALGVLAERFERVIWCPGNHELWTPPDDPVQLRGVERYDALVELCRELGVSSPEDEYAVWTGADGPVVLAPLFVLYDYSFLVPGVRTKAESLARAYEVGVVCTDEMLLHPDPFPSREAWCADRLERTERRLAELPSDREVVLINHFPLVRAPTRILRYPEFAQWCGTTRTADWHVRFGARTVIYGHLHIPRVTWHDGVRFEEVSVGYPREWRRRPGAAGRLRRVLGTRAPSTPARVGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5S0</accession>
    <name>A0A010Z5S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852621.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124855_1_0_11"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="46"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="18509" checksum="3A3356791E6E3454" modified="2014-06-11" version="1">MPYLVVAVVAVGLLGLVNLMLLTAVLKRLRAQPAEGHRSAFEQPMPPVGTVVDDFAVADVDGGTWSKDSLTGDTLVGFFSPGCPACEDLLPEFVEYAAGFPGGPDRVVAVVEAIPDDAGRYVSLLAPVARVVTDPPGRTVVVPAFAARAFPGVVIVDATGRVTVSGGDVTALPAPAPAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z649</accession>
    <name>A0A010Z649_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852693.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124855_1_0_11"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="18390" checksum="9DFF9B6D984511AE" modified="2014-06-11" version="1">MAYVVAALVVTNVLTLLNLLLLFGVIRRLREQQNNPVPPGRPGPASLPVGTPIEAFTTTDTDGRTLARDALPDGAVVAFFSPGCAPCEVLRPKFVAHAESRPGGRDGVVAVVVGPPSETAEYVSLLAPVARVVVEEPGQGVVAAAFAVTGYPAVFQLDGEGRILLSDASVDRLAVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z682</accession>
    <name>A0A010Z682_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavoprotein involved in K+ transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3978"/>
    <dbReference type="HOGENOM" id="CLU_015676_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="588" mass="64817" checksum="9584459074427045" modified="2014-06-11" version="1">MSRTASDTITDWLNDFESALAARDADRVAGLFAPTSFWRDIVAFSWNITTVENRDGVRGLVAATAATTDASNFRVREEPEEADGVTTAYFTFATAVGRGSGLLRLTGEGAFTLLTTLDELTGHEEKRPKGVEHGARRDRVTWKERRAAEIADPDPYVVVIGGGQGGIALGARLRQLGVNHVVLDTHERPGDQWRSRYKSLCLHDPIWYDHLPYLPFPDNWPVFAPKDKIGDWLEMYTRVMEVNYWGSSTARSATWDDVAKDWTVTVDRAGGEVVLRPKQLVFALGVSGKPNVPVIPGQDVFAGEQHHSSQHPGPDGYKDSTVVVIGSNNSAFDICGALWEVGADVTMVQRSSTHIVRSDSLMEIALGDLYSERAVAAGVTTHKADTIFASLPYRILHTFQIPAYQAIAEHDKDFYARLEKAGFRHDWGEDGSGLFLKYLRRGSGYYIDVGAADLVADGEITLAQGQVVELTEHAVRLDTGEELPADVVVYATGYSSMNGLAADIVGQPMADRVGKVWGLGSDTTKDPGPWEGEERNMWKPTQQEGLWFHGGNLHQSRYYSLYLALQLKARQEGIPTPVYALQEVHHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK17</accession>
    <name>A0A010ZK17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847354.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.22"/>
    <dbReference type="HOGENOM" id="CLU_055068_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="140"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="33197" checksum="3F4D4410CCA2171B" modified="2014-06-11" version="1">MTEESAQTTATPVCYRHPDRSTYVTCVRCDRPICPDCMQPASVGFQCPECIREGRKTTIPARTVFGGSLSGEQGTVTRSLIVINVVAWVLTVAAAVLTSEISIRELGRFVIFGGVTGVTEWGAAIPAYGGGFIQVQGGIAAGEFWRLLTADFLHYGLIHLAFNMYALWILGRECERLLGRARFLALYLFAGVGGSVAVYLFSPLNQASAGASASIFGLLGAMFFFLRRLRADPRGLVFLIILNFSLGFVVANISIWGHIGGFVVGAAVGALMAYLPAGPNRARLQWIALGGVAVALVVLIALRTASLGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKC8</accession>
    <name>A0A010ZKC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847555.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.123"/>
    <dbReference type="HOGENOM" id="CLU_100715_4_2_11"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="13932" checksum="74DAB4789FCC0D43" modified="2014-06-11" version="1">MAVAFVNPPGIPEVPIYHQVSVASGSKLVHVAGQVAWDADGKNVGEGDLAAQVEQCYLNVGAALAGVGATFDDVVKLTMHVVDWQPDQMPRVLDGIARAAAKLGITPAAPASLFGIVALDVPEHLVEVEATAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKG2</accession>
    <name>A0A010ZKG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1913556_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="13906" checksum="8338B72A293C94CC" modified="2014-06-11" version="1">MTSAQQSWDSSGAWDPAPQRQPPGYVPQPAPPPVPRRPRFRESGPVRWWGVLIGVCVSLVYYVLVGLVSWSTTSLIGLFLAAVLLGGSAGTVLITRGDRGMGVGVAAVSGAALSVAITVLAWNTFNLDQAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL86</accession>
    <name>A0A010ZL86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848057.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.443"/>
    <dbReference type="HOGENOM" id="CLU_031460_0_0_11"/>
    <dbReference type="OrthoDB" id="1121551at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="42922" checksum="1AC646752994E2AB" modified="2014-06-11" version="1">MGSVAETADVAVYLRGLKARSNQSYKALARQVKVGSSTLHRYCSGEQFPADFRVVRSFAAACGASTSELQLLEQLWSADPRNPAIAAGLPPSPAATAASDPGSAQWAGPTKAEEEERAGEEETAREEETAGEEKTAEAAASTVTGAADAVAEVSARATPVPRRWSARRAWLVAAGFAVVAAVMVAATVFVTRSGGGAEPRESELLFSSACQGPVSMGQHDTCVEEVQRLLASTGVKIGVDGDFGPETLRRVTAFQVLAGLPVRGVVDDATKRALYAGQVSMRSWPPARVEQRIREVFPEEPDRAVAIAKCQSLLDPFWVLPNVDTSRNWGVFQISDRRLRELDGTPRRAFDPEWNIWAARELWRTRGGFAGNWPYCDEAYPRSRAPSSPPPPSARGGPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLC8</accession>
    <name>A0A010ZLC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848145.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.492"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29996" checksum="45FC5E160CF61D00" modified="2014-06-11" version="1">MRRDDDFGTALRTLRQRITPAEAGVPASLPAVRRVPGLRRDELAGIAGVSEEHVKRLEQGRRKPSPGVIDALARALRLSSGEHARLRALAGFAASPEPDGLVPREVTGTARRMLERLSDVAVCVCDASWTVLAANDLWHSEVCTIPETPGRGRNVVWRAFTEVGPSVFRVPDELDGFRATVVAELRETVRRYPADVELASMVADLHARSPEFVQLWNAPPVPGGHADQLRVPSPTHGHVDLDLDVLTLDPGDLRVVVYTHAVPRESYSEVSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMJ4</accession>
    <name>A0A010ZMJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848670.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.929"/>
    <dbReference type="HOGENOM" id="CLU_627153_0_0_11"/>
    <dbReference type="OrthoDB" id="1442134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="453" mass="47822" checksum="1755AD5379CBC168" modified="2014-06-11" version="1">MICLLPHCGYLSETSRMLELRRALRARGADVRVATHGGTYEHLLDPGYDLIGPPMSAERAAAFVRDGVGLGSPDQSMYSDDELRAYVRAEVDYFRRHDVTTVVTGFTLTTLLSSRVAGVRLVTEHAGSFVPPLFEHGLVPPPAERLARWQRAMPGSVVRRRYGRTVPGLPFYCAGFNRVAAELGVPGVPGLAALLLGDLTLVPEIPEVLGLPAAAVDGWVPGPMYRPETRLRCTGPLFARLEQPVPDEVQRFLDAPGPLVYVAITSSGVGLVRSVLEALAPLAVKVLVAATVHDRTALADVTGTAKFLVAGVLPSHRIMPRADLAVTAGGQGSVQTAMASGTPLLGIPLQPEQLLNVALVERLGAARSVPSGQATVSRLRRVARRMLGDPSYRRAAERIHDRYADVDGAALAAEAILDGEAIVPRAGASGAGASGAGASRAGGRESEKWGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMJ8</accession>
    <name>A0A010ZMJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848676.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.935"/>
    <dbReference type="HOGENOM" id="CLU_876924_0_0_11"/>
    <dbReference type="OrthoDB" id="844909at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35370" checksum="75E71223F9ADC475" modified="2014-06-11" version="1">MSTVEASYGEATARRKVKSVPLAHLSVELGHLYHEDFDPEGPALARHFARVAPQLEAAKLLYAPPNGSRLRMSTCYLVDDYFTEFESPTVVIPALQQAAASAGLRIDYLAREAGCASADGVDLASLVERRLVPEPSADTDGSRPPVTQTGWLSNGRRSPVGGEAMGRVPRWGPPEENSARRHSIFVDVELWSEKDGDRTWSCPFLAAVWQLMRLGMLRFHGSPVAQPRSVDLNSVRDWDELPAVIQLNQKAQAFSAYQTFSVLSGRFLSVEHAVRVILEQVSVDDAVLTQIAERSEGEGFVLPAEIVRRINYFLDGSIAGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMK6</accession>
    <name>A0A010ZMK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="9">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metG</name>
        <name evidence="13" type="ORF">CryarDRAFT_0961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848685.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.945"/>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_11"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="6"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="12">
        <location>
            <begin position="422"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="348"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="596" mass="66013" checksum="E49F776B2E6192F5" modified="2014-06-11" version="1">MTRHILTAVAWPYANGPRHIGHVSGFGVPSDVFSRYQRMAGNKVLMVSGTDEHGTPILVQAEQEGVTARQLADRYNRVIVDDLQGLGLSYDLFTRTTTRNHYAVAQELFKTLHRNGYMIEKTTKGAISPSTGRTLPDRFIEGTCPICGYPSARGDQCDNCGNQLDPTDLIDPRSKINGETPQFVETEHFFLDLPALAEALGSWLQTRTDWRPNVLKFSLNLLDDLKPRAMTRDIDWGVPVPLPGWEDNPNKRLYVWFDAVIGYLSASVEWARRSGEPDAWKSWWCNPEASSFYFMGKDNITFHSQIWPAELLGYNGLGARGGSPGEYGTLELPTEVVSSEFLTMEGKKFSSSRRVVIYVNDFLSRYDADSLRYFIAAAGPENQDTDFTWTEFRRRNNDELVAGWGNLVNRSISLAAKNVGAVPTPGTLTEADAALLDTSKAAFASVGALLERSRFKAAIGEAMRVVGEANKYLSDQAPWSLKDPSTHERRDTVLHTALQVVDDCKALLTPFLPHSAQKVHELLGESGVWSGSPEIREVSEDGGPDYPVIQGDYAAAAARWASRPIEVGRPLAPPKPVFKKLDESIVDDELARLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZML5</accession>
    <name>A0A010ZML5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569749.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086041_2_0_11"/>
    <dbReference type="OrthoDB" id="1632431at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="16389" checksum="85B5B1A97A0F546B" modified="2014-06-11" version="1">MSHLPVDHPLRGLYRGLTIVTGAASIAFGATALATTSGNGFTDPEGEKVWGLMAANPAAGVLWIVVGAIAVLAALAGRNIDAKVNSVLGPVLWVVGTIGLCLIRGENNFLAWSVTNVCVMYLLGTLWFTAALYSGVSGSQPVSRPEAAGRVAEEALGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMW7</accession>
    <name>A0A010ZMW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848788.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2786891_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="68" mass="7303" checksum="7BBC1F06F1F51BEB" modified="2014-06-11" version="1">MRWHRDLTGGDVSTAHALLNQHSRYVEGGVDRCAGLHGAHAQAPRWPCSQASWAISALAAEDRGEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN60</accession>
    <name>A0A010ZN60_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="4" type="ORF">CryarDRAFT_1189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848909.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1169"/>
    <dbReference type="HOGENOM" id="CLU_012431_9_2_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="433" mass="49137" checksum="1DE8273AE7649B2C" modified="2014-06-11" version="1">MTAIEELRHSPDQLRTRIAAELERARDRSRRLTDIDHDELVRQHSPLMSPLVWDYAHIGSQEELWLVRDVGGREPVRPDIDDIYDAFRTKRADRPSLPLLSPAEARRYVREVRDKALDVLDRTPLTGRRLVEAGFAFGMIVQHEQQHVETMFATHQLRVGAPVLDAPAPPSGSAPDRPEVHVPGGMFLMGTDLEPWALDNERPAHAVGVEPYWIDTDPVTNAQYAAFIDAGGYDNPDWWTADGWAYKNTAGLVAPQFWDEGARTRFGHVEPIPPDEPVQHVCWYEADAYARWAGKRLPTEAEWEMAARFDPETGRSRRFPWGDDDPRPEHANLGGTYLQPAPVGAYPEGTSPLGVRGLMGDVWEWTSSDFTPYPGFAMFPYPEYSEVFFGPEYKVLRGGSWAADPTAVRATFRNWDYPIRRQIFAGFRCARDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNM5</accession>
    <name>A0A010ZNM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849092.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1315"/>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_11"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="41672" checksum="A53DCFFC04443BF1" modified="2014-06-11" version="1">MGRPTLPLGTHGAISIEKFGAGYRARTRYRDYDGVTRQIDKHGPTKGAATNALLEAVRDRGRRSGINEINRLTLMQVVIDAWWDKIEAGTLSPGTKEAYRYRLDGQVIPALGKLRVHEVTVSVVYRHLRKVLEKHGPAIAKMTRTVLSGVLTLAVQHDALDRNPVREMGPLTDRKPRRKARALTVDEARKLRASLAANKKAVDRDLPDFVDMMLATGLRISECSAIVWDALDLDAATVEVRGTVIRIKGVGLAIKPEPKSEAGYRTLVLPRWAVEMLRRRHSAAGGSPRGDDPVFPAPLGGLRDRSNTSADLADAFEDAGMGWVTSHVFRKTVATLMDRAGLTARAAADQLGHAKPSMTQDVYMGRDVADTGAAVVLEQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPX3</accession>
    <name>A0A010ZPX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849759.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128792_1_1_11"/>
    <dbReference type="OrthoDB" id="1969904at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="14636" checksum="E88B66F40C4B409F" modified="2014-06-11" version="1">MSTRPEGEHGSIAVEFAILVPAFLLLIAVAAVIGRQTVAQTAIEGAAHDAARAASISRTADTAQNRGNDAAKSVLDAQGLHCDPVTITVDTSQFARPVGQAAAVTATVSCSVAFSDIAIPGMPGNRTVSATFTSPLDVYRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ60</accession>
    <name>A0A010ZQ60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849870.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1847"/>
    <dbReference type="HOGENOM" id="CLU_096980_1_0_11"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14368" checksum="F17C3ABAEC953B41" modified="2014-06-11" version="1">MDSEIITVRTGSSPVVQDLTDRAADFVRSRGDGLLHAFVPHATAGLAVLETGAGSDDDLLAALEDLLPADDRWRHRHGSPGHGRSHVMPALIPPYATLPVLGGRLALGTWQSLCLVDLNVDNHDRQVRFSFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ73</accession>
    <name>A0A010ZQ73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0382</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847921.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.367"/>
    <dbReference type="HOGENOM" id="CLU_005108_4_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458048" evidence="7">
        <location>
            <begin position="35"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="213"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="525"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="668" mass="69397" checksum="7851019B1730C23E" modified="2014-06-11" version="1">MPEIVTGRRSAWLVLLLAVLLSGLVIAFGGTAENSNEPTAALPSSADSSKVAELQKQLPSGETNPALILYARDGAPLTQADTTTIEADAKAFRGSPPIYSPDRTAALLAVPFAADLENDVVIDRVTDLREKAKADLPDGLTAQVTGGAGFRADIASSFSGANFKLLAVTAGVVALLLLITYRSPILWLVPLAVVGTADVVAGSVIALMSRATGLNIDPSTTGIVDVLVFGAGTDYALLLIARYREELRLTEDRREAMRKALRSGGGAIVASAVTVTLSLLTLALAILENDRAIGLAGAIGILVAAVFGLVVLPAALVVCGRGLFWPFVPKVGDQDKARTGAWARVASGVARRPVAVIAFSVVLLGVLSAGLVDARLGLSQSEQFRVKAESVDGLKALARYYPAGATDPVAVMTTPDRVAEVTRLAQDSPGVASVRPGEKTGDLAEVDVVLDAAPATAESYDAIRALRDRLDPTGALVGGSVATELDTREAAIRDLEVIVPLVLGVVLIVLIVLLRGAIVAPLLLMLTVVATFFAALGASTFLFTHVLGYPALDTGVPLLAFLFLVALGVDYNIFLVTRAREEALHHGTREGIVTAVAVTGGVITSAGILLAAVFAVLGVLPLITLTEIGVIVGLGVLLDTLLVRTVLVPALVVLLDKKFWWPSSLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQA7</accession>
    <name>A0A010ZQA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849958.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1908"/>
    <dbReference type="HOGENOM" id="CLU_190784_0_0_11"/>
    <dbReference type="OrthoDB" id="2059215at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="7039" checksum="606507ED7824C611" modified="2014-06-11" version="1">MTWQWRYAGSGDQGQASEEFPSQSDAESWLGEQWRELLATGIDEVTLEENGRVEYAMPLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQD2</accession>
    <name>A0A010ZQD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite-activated ATPase ArsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850005.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1943"/>
    <dbReference type="HOGENOM" id="CLU_040761_1_0_11"/>
    <dbReference type="OrthoDB" id="1225869at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459151" evidence="2">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="4">
        <location>
            <begin position="318"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40431" checksum="BD25CC4CC0A9B9CB" modified="2014-06-11" version="1">MRVVLFTGKGGVGKTTSAAATAVLAARAGATLVVSTDPAHSLADALGLPVGAEPTPVADGLHAQQVDPQARYEQYWGTLRGYLTTVLRHGGLSGVAAEEIVVPPGLDDLFALFAVRDEARSGRWDTVVVDCAPTAETLRLLTLPDVLGWYTDRLAPLHRRLSGVARPVLGRELQNLLPDDAVVSAVQKLRTALADVRDLLTDPQTSAVRLVLTPEAVVLAEARRTFTALALHGFVVDGAVVNRVIPDGDDPWRAGWAAAQRAQLAEARESFAGVPLRTAPYLPGEPVGVPALTELAEALYGDDDPVAAVPVEPPLRLDGDAVLSVALPLADRSEIALSRVADDLILTVAGRRRLLALPTVLRHRAVAGARLQDGRLEVRFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQG0</accession>
    <name>A0A010ZQG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850042.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="22307" checksum="8BECEEAD8BE86B5A" modified="2014-06-11" version="1">MIVVAGGEAPNADALAGLPADAFVVAADSGADGAHAIGLRVGLAIGDFDSASEGAAERVEAAGGRVERYPAAKDATDLELALDAALARRPGRIVVLGGAGGRFDHWLAVAFLLASPLYAGVAIQARWAEATVTVVRSSGTTLTGRPGDVLTLLPVHGPALGVRAEGVEWPLHDEDLAPGTTRGVSNVLTRTTARVSTREGVLLAVQPSERGQPVSPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQJ8</accession>
    <name>A0A010ZQJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="28282" checksum="40FC0832398E50B1" modified="2014-06-11" version="1">MPDSDVHVLVDGDPDTSTLLLLTNAVAPSAIWNPVVPALAESHHVVRVDLLGHGTPPRYDVATQVRRIAAVLDRLGRTRVTAVGHSSGSMLATALAEARPDLTAAVALLDMGPDLTAQLPESLLFRLVRTRFPGAVLWRLRSPKSMAKAARGTAENVRIPESWFEHLHRMTHRDFLGVMGAYRDYLEERSLPDRLRGSGLPLLVIFGADDERWRASSAEAYRVVPGARIELLPGVGHTPPLEAPEPTAALLLDFAATLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR52</accession>
    <name>A0A010ZR52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848459.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721265_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458059" evidence="1">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="367" mass="38614" checksum="9750E34D84BB0175" modified="2014-06-11" version="1">MRLSTRMTRIAVAAVCLMLAVTSCSEENRYADVAVAATADNSGQADINKDGKVVILVLSPGDLNDNGYYESFLNKASAFAARQGWTIERQGNIKPGTSLAAAKKYCAQYKPDLVALGASEIEDAIPAATNGDCGKAYWYVPSSTITDERPGIVVSQDFTFESVIAAGYASGLLMKFKGYDKAGFISGPAVGFATDAAKAYYAGLKLALGSSPLEFKAVFTGDLNDGKLASAAMKELADEGAKAVYPYLGGGTDPAAKVGNSRGVLLATPGTNRCDSTDPKFDVSVIFDPGEYFAAALQDFAEGELKMGTRRVWHIGVDQVPTVRLCNGTDDQNAELAQFITNIGSGKVNVTGEVNKYGPQVELPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRF0</accession>
    <name>A0A010ZRF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850454.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2292"/>
    <dbReference type="HOGENOM" id="CLU_088252_0_0_11"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="20978" checksum="F787C19DBD95226E" modified="2014-06-11" version="1">MHIAILTFDGYNELDSLIALGVLNRIPGLRATIAAPTPTVRSMNGVVIESMATLDEAGDADAVLVGSGIATREVVEDPTIMATLARLDPARQLVGAQCSGALVLARLGLLSGVPACTDLASKPWVVAAGVEVLDQPFYADGNVATAGGCLASQYLAGWVVTRLVGADAARDALHYVAPVGEKEEYVERARRAIAPYLPVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRU5</accession>
    <name>A0A010ZRU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570066.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537528_0_0_11"/>
    <dbReference type="OrthoDB" id="1926210at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="17898" checksum="476A1F83D1D20134" modified="2014-06-11" version="1">MARLPAGIYLRRPGYRILSALVLGVIVAGVVLLARLFGSVTADGTEAAPVPAPSRTVSSTEGDDSVYAEKSASTAPAAGVGEAFVRAWLQPTDGRSQGQWYAGLARYALPDLAAQLKNADPTTNPATAVTGEPTTTVISETSAQVVVPTDAGKASTLCVLTEDGWRVATIDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS98</accession>
    <name>A0A010ZS98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxypyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hyi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850916.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2632"/>
    <dbReference type="HOGENOM" id="CLU_050006_1_0_11"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28259" checksum="433217E0BB629876" modified="2014-06-11" version="1">MRYDVNLSLLFTELPLLERPAAARDAGFDAVEFWWPFPDAVPSDAEVDRFVAAVRDAGVRLVGLNFFAGDMPGGDRGVLSWPGRTGEFLDSVNVAVGIGAQLGCRAFNALYGNRLGGVDPGEQDDVAVEALVLAAHAVSRIDGTVLIEPLSGTPRYPLRTAADALAVIDRLPGRANLRLLADLYHLAVNGDDLDAVIERHTARIGHVQIADAPGRHQPGTGSLPLARHLEQLTAHGYDGWVGLEYIPEGPSADSFAWLPRAGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTM1</accession>
    <name>A0A010ZTM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1618"/>
    <dbReference type="HOGENOM" id="CLU_409233_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="671" mass="70025" checksum="40D95000FA952115" modified="2014-06-11" version="1">MVEQVPAADDKRVVVYASGADGGWGVLLTHGPSRRELSGAEAGAARERMSLLAVVNAVECLTRPTSVLVLTDNEYVRAGVAARTQGAVSDSRNNDLWGRLGTAVKQHRVQWVVVDAALAGRAAALASDPASAPRRETNAPPRAQVEAPAFRPEPPTPDQHRTPSSPPPRREPSVAPSRREPSMAPHRAETVGPPSRADAPSPASRREATDAPFRREATDAPFRREATDAPFRREAAQAPPHREDTDAPFRREDTDATFRREASGAPFRAEAPDTPPLREVPGAPSRRQPAAAEQVRQPAEAAPHREPAESTARHRPTTTAPPREPAEPERNQSAPAAPRTAPASRDKTAPRTDPASQDDTSPPAESAPRGEAAPPAESAPRGETAPRDETGSRGETGSRGETGSRGETGSHTEASPRGGAAPQGERAALGAEGREVSAGQPVAGEGGAPVRRGLPAELVAAMRPASTLGRPTGERTGLPFRAGDPVPTREPAADPTTTDSAAPAATDPAHTSESDVERTPPANPAPTNSALTNAAATDGATGSGTTGSGTTGSDGSAGGGKATGAGSGDDELGDDELGDEADDGLEEFLEELQLWLEDEPAPTDPIDEWLRGTPLRIGVINVDSIVFETPDGRTLGPILLPEGLVDQVELGWRPRLTAARTGDTWHLRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTP8</accession>
    <name>A0A010ZTP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849549.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721042_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="39924" checksum="14ABA676FFB72476" modified="2014-06-11" version="1">MAIAEELIAGIISSVLAVLLVEIYLWLRRRYRQRALRWLVGTDTVSVITPVYPWAENAHPAGLLTTYDAIGLAHVLEACNRVGTVPVVTRSGESAENSPLDVVAIGGPSGNQVTSTFLKAYCPGFEIITDPVTGQLSYRCGDRVFTRSDDETFAFIVRLSPRETGLPGTALIAWGHSAVATASAGYYLAKYPSALRKVGKGSFFVAISVRGVLGYRSFDTRPTDLTRTAFAPPVGGSRPVDGAGTGAGSSPAPAVGSAPAVGAASAAGSVSDSVLDSDAEREPEPRRRFGRSSRSTPAPRSPATGRSRVADALDDVRAETSAVTTADPTPTGTIAVPPLAAPAAPEPPPGESSSPPPSGPAKRPPRRTSGTDDPDPDRTRKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUN8</accession>
    <name>A0A010ZUN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852189.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2179456_0_0_11"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="109" mass="11608" checksum="2A53E2CDA6DE2F25" modified="2014-06-11" version="1">MTTFEPHVEDGEPVVTYEVRGPVAVVTVNRPKYTNAQNSKVTYALDAAFVRAVDDDTVKVIVLAGNGRHFSGGHDIGTPGRDIDEPFQRKAATDKQAAAEAAQRAGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUX6</accession>
    <name>A0A010ZUX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864525.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3655"/>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="25570" checksum="B996F7AF581D5757" modified="2014-06-11" version="1">MTHRKVRDVMTTDVRTVHVGSPAKTVAGQLEAGSVSALPVVDDDRHVVGVVSEADLLHKITYQDDADDLPRIFRRHRADRAKADGESARTLMTSPAVTIGPGASVVEAAALMERHHVKRLPVVDDTGDLIGIVSRRDLIRMFTRTDDEIRAEVEHEVLDRVLMLEPGTASAWVANGHVTLRGRLRRKSETEIAVALAGRVDGVVGVANSMTFDQDDTTYRALRDDVASRGIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV17</accession>
    <name>A0A010ZV17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850200.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2113"/>
    <dbReference type="HOGENOM" id="CLU_482048_0_0_11"/>
    <dbReference type="OrthoDB" id="1786325at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="636" mass="64164" checksum="71C20E3591E5ACD3" modified="2014-06-11" version="1">MRPDHRRDRPGGADDGFTLAELLVAMSVVTIVMTSLGTFFTATVTRTAAQGNVSTAVQLVSDGLERARAIRGASLVTGRDRTATLQQWSAADSVVSPLLATMQQAYDPNPDGRAALLPATPVPVTIDGLGYTQSWYIGSCWQLRSGGDCTAVSSLGAAEFYRVVVEVTWPHRNCAGNLCTRVGTTLVSSTAADPLFVSGQSARPPTVVSPGAQVGEITVPVTLTVTATGGATPLSWTAQGLPPGVTISSAGLISGTPTAVGSYSATITATDAFDLVGIATFSWTVNALPTLAAIATQSSQGGRPITPLQPALTGGTAPFTWKATNLPPGLTIDPVTGVVSGTPTTVNATGSAVSITVTDSYKKTASVGFTWKVPVLVLTAIPAQTDSVGYAIPALTPDATWGVKPYTWKATSLPAGLSITTSTGEITGTPTTVGTASVTVTATDAVNTVKSTTFSWAIGPAVTAPGAALAGTVGSAFSYTSTAATGGTKPYVWSAAGLPDGVTIDSATGAITGTPTVSGRFIFTVTATAAAPRPATGSSIRLAFTVSAVGSGLKFATAPTSPLNTASGATVSQQVTGTGGKAPYTWGVTGLPPGLSMSATGLVTGKPTTVGTYTTQFTLTDSLGARARWTITWNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVA8</accession>
    <name>A0A010ZVA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852553.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3798"/>
    <dbReference type="HOGENOM" id="CLU_100689_1_0_11"/>
    <dbReference type="OrthoDB" id="1694303at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="113" mass="13315" checksum="B0413B13F3840C75" modified="2014-06-11" version="1">MSAAEPQRHALVVGLRPERREEYLRLHREVWPQVEQTLRDANVTNYSIFVTGDTLFAYYEYVGDDHDADLARVAEDPVTREWWTHTDPCQVRIVDERVPGALWQPLDEIWHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW34</accession>
    <name>A0A010ZW34_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">CryarDRAFT_2541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850745.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2502"/>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_11"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="37"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="211"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="217"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="472" mass="51579" checksum="BEA6AC98C687F746" modified="2014-06-11" version="1">MSDNWTQLAEEYEISDAELASLDSDEGGDDDVPGALPVLAVVGRPNVGKSTLVNRVLGRREAVVQDVPGVTRDRVAYDALWNGRRFTLVDTGGWEPDAQGRAAAIADQARYAMTVADAVLLVVDARVGITETDAAVARVLQRGGKPVVLAANKVDDTKGEADVAELWRLGLGEPWPVSALHGRGSGDLLDKVLEVLPEAPQEGRFGTGGPRRVALVGRPNVGKSSLLNAVTKENRAVVDAVAGTTVDPVDSLVELGDEVWRFVDTAGLRKKVTFASGAEYYASLRTAAAIEAAEVAVVLLDASEPLSEQDQRVITTVVETGRALVLAFNKWDLLDEDRRELLEREIDRDLQRIRWAPRVNISARTRRAVDKLAPALRTSLEGWEQRIPTGRLNSWLSELVAAHPHPVRGGKQTRILFATQAGSKPPRFVLFTSGPVDVAYTRYIERRLREDYGFAGTPIQITVRIKEKRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW49</accession>
    <name>A0A010ZW49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570700.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4070"/>
    <dbReference type="HOGENOM" id="CLU_085041_3_0_11"/>
    <dbReference type="OrthoDB" id="1608763at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20536" checksum="4A8D1D73DAEF0B2F" modified="2014-06-11" version="1">MSIIEALRTGTRDHHHRLEEHLDLPGRIRTPGDAGAVLAAFLAAWEPLEASLAATPGWGSLGLPADLGTSSPLLRADLGAVGGAELPPAPSPPFGSLPAAVGARYVLLGSALGGQVLAPEIRRVLGPGAPDATRFFRREGRNPGREWRDFRVALAARPWTAAERDEAVASARATFDHIATTAIRCGITPGPPTEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWG9</accession>
    <name>A0A010ZWG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853253.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4194"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="350"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="488"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="769" mass="81960" checksum="A7E643E5AF05F075" modified="2014-06-11" version="1">MEGSRRWTLRARRSVVVLTGLVVVGQVVGFTVEPARSPVFGLSLVGLDALGLIYSVRAARRSASRRIWGTTAAGRGLSVLATVSFTVAALTGNSGWPWFFAIVSGLAMFTALSAACLAVTTERYDPRQRRAFLAEAVTVLSSAFVVAWYFILHPAIDRSTALELLYDIGYPLGNLLLLAAVCAVLLRGAVAHLTRPVALLLGGMLLYAVGDIAFSAMRVHGEQGSPNTPAGVALVFASLLMTVGAMEECALPPTDRDARLTRMPAWSMALPYVAVAVGNVMMLVAVVHADNRDLWGGLLLGQALMTTALAVRQLISLRESSERNVVDPLTGLANLTGLKAAARRAQQRREPVALLLLDLDGFKQINDRYGHEVGNSVLVEFARTLRGAIRGHDTAARVGGDEFVILQTGATTEAQAVVVAERVLAALADTTVRVGDETIPIRTSIGLALGSATDSPQELQHKADLAMYESKRAGTHGWKAYDESMTDRRNRDALLAAELERAGDQLSVLYQPLVDLSGGGAVAVETLLRWQHPTLGAISPAEFVPIAERSGAIDDIGRRVLDLACRQVRAWIEAGADPDFYASVNVSPRQLEDPAFLDDVLTVLERSGLAPRNLVLEITETAIVDQRTAIPVLTALRERGIRIAIDDFGTGYSALHYLTRLPVDVLKIDGSFIAQLNGTRQGAAVTEAIIRLGRILELTTVGEGIETAAQAAELQALGCAIGQGYLFARPATAADLDPMITGRSPGTGTRPAEPDGRHPAAASPARAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY94</accession>
    <name>A0A010ZY94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570359.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335693_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21957" checksum="17539C3F5E45A244" modified="2014-06-11" version="1">MTGAMHDPGDTFGRLARVLSEPHAAVAVDAFGRVSSLSGIPGHPLLGAESPVVKLAVSQLVSDQPHTAFLWPWRSAPTHAGPVQDNYVRITGLACDASPPTRPAGLILLQPIRDTHGLTPRELQILGLLVDGGANQHIASVLFITARTVAAHLEHIRSKIRAPTRTAAALYAVRHGLYLPAQLVDRRGRTSRPWAGPPIERAWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYT6</accession>
    <name>A0A010ZYT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852113.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3508"/>
    <dbReference type="HOGENOM" id="CLU_047832_0_0_11"/>
    <dbReference type="OrthoDB" id="1661570at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="450" mass="46608" checksum="FCFE3900034D57AE" modified="2014-06-11" version="1">MAGPTRIELRRSNARALGLVVGVVAAAWFAGETGHWWRQWNSLAIVATSAMFVLAPLALAGGAMFGRRDGLTRADELISSTGRPRWHRVTPGIAALTIATTVGYLLVVTVDAVVVAVNGSYLGVAGLLSMLVDVTVLAGAVWVGIGVGRAWPSPMVPPALAVIGLVVQLAGDTITGPDGSATPLAALSMLVQPLGADWETASRAAVLGRLALGLGLLAGGALLTVGASRLIRAGGPVAVAAGVAVMMVVSPTAASRPTNQIDAAAQRLVCANNGPQVCVTAVHAYLLPSVVPQARAALTKLAKLPDAPTRIVEWHADTVGTGDDFDYLSDTPKTEPGTVFFRLDLADQDRDTDIEASILNGAGTTANGCRLNDPDALWAAGAWLAGGDTLDVKDFVFGLKLFPDDYQPVLRKLREAPEKEQIRRVTALRDAANACRTTNLTAILTGTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZB1</accession>
    <name>A0A010ZZB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852423.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3715"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_4_11"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21617" checksum="D0020AE63FE97A47" modified="2014-06-11" version="1">MEYAIEVIVLPVSDVDRAKAFYTALGFREDVDYRGPDGFRVVHVTPPGSAASIVIGSGITEQTPGSSQAVHLVVDDIRAARADLEARGARPSAVFHDAGGVFHHAGVVDRVPGPHPDRQSYGSFLSFTDPDGNLFVVQEVTTRRPGRVDRVVYRSVDEVEKALIDAARAHGEYEKEIGRADENWPAWYAAHLARAAGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZD0</accession>
    <name>A0A010ZZD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852450.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_5_11"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="25559" checksum="BB375459B361E8A9" modified="2014-06-11" version="1">MTDTQVRVRAAYSVVLERLRRDIMLSRILPGERFPPEREHAERLGVSRVTLREALRVLEGEGLIEVRRGVNGGSIVKAPAVPDGRTPPLAPWSEIEGLLEFRASIEPLAARRAAQRLTDEGLAGLEAAVRGLDTASDIATFRSLDSAFHLLIAELADLPLLLDAVEATRIAMFESLDRLDFDVVLASTQRAHRRVLAAIVEGNPKLAERRMTAHLADSSREVAEVYARFVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZJ2</accession>
    <name>A0A010ZZJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3806"/>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="32557" checksum="3BFF22D9032B6E2F" modified="2014-06-11" version="1">MIERVVTVGEALAVFRAGDDGPLWSAPRVAVSTGGAEANVAMALARRGVPVSWFGRVGDDSLGRRVTRELRAEGVDVHPVVDPGGPTGLLVKERGADGRTSVVYYRRGSAGSRLSPADVERIPLSRTTLLHLTGITPALSDEAGAAVDHLLDRADAAGATVSFDVNHRGRLWPAEVAAPVYRALASRAHLVFAGVDEVPFLLPGRGGADAGAAALALAERGHAHVVVTAGAAGAVACVDGSLHAVPAVPLDGPLETVGAGDAFVGGYLAELVAGRPVECRLRTGARLGAAACRHPGDWEGVADLSGLDPAEASTDPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZW5</accession>
    <name>A0A010ZZW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570652.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="OrthoDB" id="1687561at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="25774" checksum="BD4D5A68A2255544" modified="2014-06-11" version="1">MARPAVTPRKILETKYRISETAMALFLEEGYANVTVEAVAEASSVSRRTIFRHFESKDELVFPDHTERLGLVGRCLDDSAPGADPVEAVIAATEESLREFVSRPDLVLRRYQLTRVVPELRKREVIEHERYVALTRSFLRDHLPADAPPFQPVALAALIDAIHRSALGHWVRTGGATDPLAELAAGMEWVRRLVDHQSTFSAAPLLLAVLPDTPHTRRALTSLKDEAQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZZ3</accession>
    <name>A0A010ZZZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3949"/>
    <dbReference type="HOGENOM" id="CLU_069356_32_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="23014" checksum="95F25F80B53FF6B2" modified="2014-06-11" version="1">MPAIRSRRAPTKGDQREQALIDAARVVFRDRPISQVTIDELAGAAGIARSGFYFYFESKQALLAAVVDQGIAEADVEMSEWLAADGLGRAELRRGLAAGLARWKVDGRWLREAFITPDPGPEVAHVRDRLIDQGCNLFSARIERDARAGRALAGPPDLIAQLAVRLRSTMFAEVYADPGGYDEDALLDTLTDAILRLVYGETPTEAPPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAG3</accession>
    <name>A0A011AAG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+/Co2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569514.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.19"/>
    <dbReference type="HOGENOM" id="CLU_007127_0_2_11"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="43350" checksum="594C9D27BAC3C137" modified="2014-06-11" version="1">MVNSEIRPTEVHSSDRQRSRPMARALAAPVRTLGKVLPRPLHGPTTAADPHPSRTPGSAIVDCGLYIDGVRKAGRMDYVAALEMAKRNDNAFVWLGLHDVTADEFADIAKTFGLHELAVEDTIVAFARPKVERYADVTFVVIKTARYIRSGELTATSEVVETGDVMLFLGERFAITVRHGDACRLRGVRTNLEQRPDLIRQGPWAVFHAVVDQIVDRYVEVVDAIEDDIDEMEASVFDSSNVDIPRIYRLKREVVELKRAVLPLARPLESLVSGAVLSVPQEIRRYIRDVADHHSRVVDQIASFDDLLNSILQASLAQAGIQQNNDMRKISAYAAIGIVPTAVAGIYGMNFDYMPELTWRFGYPLVLFIIFVICFGLYRLFKKSEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAU8</accession>
    <name>A0A011AAU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847626.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.167"/>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_11"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="282" mass="29967" checksum="7B5A55FDFE0B015E" modified="2014-06-11" version="1">MSTDVSVSDELAGLDALEAVPERGDRGRRLWRSTWPKLLAIVIGIASWQIVVETGWRPRSILAPPTEVFPSLWDMLTTGTFWGQVATTMQRAILGFAVAVAIGLVIGFAVARFAVLRAAFGSLITGLQTMPSIAWFPLAIVLFQGGDAAIFFVIVLGAAPSVANGVLAGVDYVPPLLVRAGRNMGASGFGLYRTVIGPASFPAILAGLKQGWAFSWRSLMAGELIVPIGEAGGLGTLLTVTRELSEYAQMLGVMIVILVIGIIADGVFSWANNALRRRWGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABA7</accession>
    <name>A0A011ABA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847812.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2715602_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="72" mass="8275" checksum="18692A037A08D741" modified="2014-06-11" version="1">MERPHPDVVERMSALARLHHAWTLEYAADAEPQPNDAPDYLVHHLDIDPPPGAENKFVRRAREIEGRDEHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABF0</accession>
    <name>A0A011ABF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.349"/>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_11"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="192" mass="21362" checksum="255C85E73228DA41" modified="2014-06-11" version="1">MEQVDTRVAYQNPWLSVREDTVRWPDGSTGIYGVIDKRDFALVVPWDGAGFHLVEQFRYPVQERCWEFPQGGWPPGSSGGSGLALAQAELAEETGFTARTWTRLGFLQAAPGVMSQYFDVYLASDLVAGAPSREVSEQDMRQKWVSASSLEQMIRSGELRDAHSIAAYGLFSLAMAGPRDEHDRDDQHSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABZ1</accession>
    <name>A0A011ABZ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848289.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2272687_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="10535" checksum="806A3C0E48322011" modified="2014-06-11" version="1">MRPRPPGLASERTALAWVRSLIGLLGVGLLVSRGMLVHWPLLPAAAAITVVAGLVLGACYLGERRRIALRHPRPAPPRPGTIVAITAGAVLAAALGGVVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC42</accession>
    <name>A0A011AC42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative non-F420 flavinoid oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.633"/>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023907">
        <property type="entry name" value="Non-F420_Flavin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03885">
        <property type="entry name" value="flavin_revert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="38427" checksum="3C8DF227130E0C6E" modified="2014-06-11" version="1">MTVYGVHASHEQLHPSDLLAAVAKAERLGFTAAMSSDHFSPWSARQGHSAFAWSWLGAALQATDLPFGVVNAPGQRYHPAIIAQAISTLGAMFPGRFWAALGSGEASNEHITGDPWPRKDLRNARLRECVDIIRALLAGEEVSHQGLVTVDRARLWTRPEVEPALVGAAVSEETARWCASWADGLITVGAPVEKLRRMIDAYRDAGGRGPINLQIHLSWAETSEEAEAIALDQWRSNVFDPPVCWDLDMTDHFDVVSEEVGIDQVRRVVNVSSDLGQHTAWLAEYAALGVDGIYLHHVGQDLDPFLDAFGAKVLPQLDVTKAPEARSLHEKPEEAGAPGGLPSGEGPQPTGQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACT1</accession>
    <name>A0A011ACT1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051571902.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.886"/>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_11"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="409" mass="41369" checksum="20E15327C811F1A1" modified="2014-06-11" version="1">MVITRAEAPPRTALPLAAVLVLALLSAIAPLATDMYLPGFPTMADELGTDAASVQLTLTTFMAGLAIGQLVIGPLSDRWGRRRPLLVGAAVCVLASALCAAAPNVGALVAFRFLQGFAGAAGVVLGRAIVADTVRGAAAARIFSVLMTIGGIAPVVAPLIGGALLGPVGWRGVFVVLTALALVMLTGSFFVLRESLPAPSRQGGGLAATFRGARIVLGNRQFLGYTLAFVFSFGTLFGYISASPFVLQTVFGLSSGWFSVAFAANALGVTVGSLLNARLVGRFGPRPLLTAGLGSLTLWSVLLFTLAVSGGLQLWSVLGLLWLTIFSLGFVMGNATSLAIAQTPSAAGTGSAVIGASQFALAAVVSPLVGLGGENTAIPMALVMVASALISVTAFGALTRSSAPAVQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADQ3</accession>
    <name>A0A011ADQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569817.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1233"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="475" mass="49130" checksum="9549ACC2A55BA9A3" modified="2014-06-11" version="1">MAVTEKTDRLSPEILKLAGVIMLGAIMMQLDVTMTNIATNTLLDEFDTTLATIQWISTGALLAMASVIPMAGWALERFGARRLWMVTLAVFLLGSVLCGCAWSVESLIVFRVVQGLGAGMILPLSQSILAIAAGPERMGRVMATIGIPALLGPVLGPVIGGVIVTNLSWRWIFFVNVPVCLLALALSPRFLPTVRAGAARVDLDVVGLVLLSPAFAAMIYGFAEAGRSGSFTHLSVVGPVLVGVALLAGFVVHSLRLGGRALVDVRLFHSRSFAAAAGVITLASGVMFGALGLLPLYLQQVRGEDALHTGLLLIPMGLGMGLSLMIAGRLADRVAPAPMVLAGLGFGAVAALTYTQLTADTSYLVVGLAQVASGAGVGSVLVPVMTAAMRSLTPDAIPRASVAVRIFQQLGGSVGSAVLFVVLQRAIVTGGAPSSGALASAFGETFWWVAGIALLALIPTGFLPRSSRLPEASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEX1</accession>
    <name>A0A011AEX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569920.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1636"/>
    <dbReference type="HOGENOM" id="CLU_024336_0_2_11"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458384" evidence="3">
        <location>
            <begin position="31"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="197"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="5">
        <location>
            <begin position="304"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="561" mass="58663" checksum="EF151DF5381CEF2D" modified="2014-06-11" version="1">MRARTRRNRPTRAVGVVTTLVVAALTGVAAHQMTATATPTRAIRPAPAPTTEPTRTPGATPSSTPGTPAATPPAEAGLAAGRALAAQVTVDGVLSHLRAFQQIADGNKGTRASGVGHGYTRSADYVAGHLEAAGYRVTRSKFEFPYFEEVRPTTFRRTAPTTHPYRATIDFQILSYAGSGAVEARVHPVDVTLRPPRASTSGCETADFAGFPRGAIALVQRGSCDFSVKARHAVAAGAAGLIIFNQGNGTGRDRLDAFGGTLQEPFRIPAIGVSYAVGAELAASPARSVRIETETLSETRTTENVLAELPAKRAGRTVMVGAHLDSVPAGPGINDNGSGSAGVLEVALRYAELARTSSTPNTLRFAWWGGEEAGLLGSQHYVDSLTSAERERIALYLNFDMIGSPNYELGVYDGDRGPTGSAAIEKFFQGFLADHGQKSTASEFNGRSDYGPFIAKGIGIPAGGMDTGAEGIKPKSAVAKFGGVPGVAYDPCYHQACDGLGAVKDKDRRDDYRRLARAYGSRLVGNVNVVPLDLISDAIATAVGRYAYDVSDVVGSATPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFU2</accession>
    <name>A0A011AFU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850016.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1956"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_11"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="229" mass="24481" checksum="87DE0A2DBFF5ACE9" modified="2014-06-11" version="1">MTAPGTPQADDPLAGVDLFAGLAPAVRSRVAAAAVPRSYRRGQLLFLEKDPGDSLIMVRRGAVSVFRTAPTGDRALLYVVRPPGVLGELALLDGGSRSASAEALEETHVLALSRGAFLELVRTQPPILDGVMRSFGGLIRRLTDQTSDHIFLDLPGRVAKTLIRLVGDNRSPVVTIDLNQTQLAEMAGGSRQSVNQALGTFATRGWLHTEGRKIVVTDIPALRRRAGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGL6</accession>
    <name>A0A011AGL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1218152_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="22652" checksum="DB5AB33DC5454A48" modified="2014-06-11" version="1">MSADAALRRRTTVGFAAAAMLVSYLPFSAVNGALGAIGRTADAGTSSLQWVTDAFTVALTGAVLSGGFDGVQLLRVGQAVAGVGAGLVMAASLSLIAATAPDPAARTQAIALWAAANVAGLGSGPFLAAAVPSWRWLFVPTALLAVGAAAYGPLRSREIVDDEPGRPDHLGQVTGTIGIVVLAAVFVVERRVVNPVLPPALFSSPGFTAAGAAAAAALFAIPRTTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGP5</accession>
    <name>A0A011AGP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850374.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2244"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="30224" checksum="98006C93CB7BCED9" modified="2014-06-11" version="1">MHVFVTGGTGLVGSAVVAELRRHGHSVVALARAEASARAVEAAGAEPLLGDLADLDAVRAGAARADGVVHLAFRNDFSGPDALARAVAEESAAMATLGEELAGSDRPYVTVSGTPWVTGRLSTEEDPLPLDGPVGGRARSVNGVLALASRGVRSSAVRLPRTVHHEGKGGFAGLLTDIARRTGVSGYPGDGTQRWPAVHALDAAVLFRLALEKAPAGSAWHAVADEGDQVRDIAAVIGRRLGLPVEPVAEETYGPLGPIFAADQPSSSAHTRAVLGWEPTHPSLLDDLEHLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH51</accession>
    <name>A0A011AH51_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">CryarDRAFT_2442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2405"/>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="20050" checksum="4B88196799D1C1E4" modified="2014-06-11" version="1">MTPAIDEVREILDESAVARTVDRIAHQILEKTDGGADTVLMGIPTRGTPLARRLAGRIETFTGVALPVGALDVTLYRDDLRLRAPRALEKTDLPSEGIDGRRVVLVDDVLFSGRTIRAALDALSDLGRPQSVQLAVLVDRGHRELPIRADYVGKNLPTSRTENVRVQLREVDGRDAVVIAKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI04</accession>
    <name>A0A011AI04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851043.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2721"/>
    <dbReference type="HOGENOM" id="CLU_1123092_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="26308" checksum="581BC7370C5AAC37" modified="2014-06-11" version="1">MEIASGDLQVVARVVQLLRLLAANETIDLVSAAEHLGVGKSTAHRYLASMENHGLLQRRDRNHYEFGVLLAELGTMALSRLGVLDLAGPVMEEISVAVRHTVVLSVWNGHTPVVAQVREDRSRTAHVSIPVGNLLGPDAAQTLIFWAFRDRSFYRFRAGAPPVNATDAELADAVRTGIAVRMSRENGVGAVATPVTDPSGQVVATLAVVGIAQFLPEEIDSPVARALLAGAETIARRMANPLDAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJB4</accession>
    <name>A0A011AJB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3209"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="838"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="918" mass="97621" checksum="8A56230B0A7930E7" modified="2014-06-11" version="1">MHDELVGREAELAVIDEVLNRTRPGLFFRGESGIGKTALLRESTHRAGQQGYTVLWCRGVQHEQALRYSGLHQALHPLLSGTPELPPSERQAMETLFGISDGPSPCHSLVRRAALGLLVRAASRTPVLLVLDDFDALDPDSVDVVEHVLEHRGEAPLVVLAAAGTGTAGPLGVARWDLAGLSDAAASALVEAVAPRLAAVDRDVVRDLAQGNPLALAEWSRNLMDHNVPLGTCRYDLIDFPVRLTQAFGVSRHKFPRRTSRLLLLVAAFDGDIADLPGEEGELWRAAAVLGLTRSDLCPAEQAGVVTVERGEVLFCHPLTRAVHYGTASPAARVEVHRAFADTLTPDSDRVVWHRAAATEGRDDLLAARLHAIGEKARRSGTVARAATAYEWAARLSTASDAAAYRLGLAADAALRSGHRRLGAQLISEARSLADGPAAVPDLILPEYYARLMNDVPGLSADDLLDGLPELPSTHRGLATMIAAMDVYNSGDPGGKAERIEGATLRLGSAADDPLRVITLSVVAPQRHARELIPIVRRLSGPAAELESTYLMVGMGGAAEALRLIPEAERCYRAAVAASVTDSSLLERCMSMVRHASLLTLTGAFAEALAEAEDVHRLAVRLDLTEVAASSAATAARVYAWQGNVPAAAEALTRSTRLAHLAHPHPATLTEVASARAAVALVQGRPADAVHALLGVAEHRIWAGATIGDLAEAASKLDRGFAVVDTVKSVAEDADVFASDLLRHLTLRARALGGESALFDAALAVPGEERFPVEWARTRLAYGEWLRRGRHKIRARSHLAAAMAVFARVEAVPWRDRAAAEMRAAGGAVESSGMDSDGHPGRVVLTPQERQVARLAGGGLSNRDIAGRLALSPRTVGTHLSNAYAKLGIRGRAELAALVRDRPEPETTGVAAQTRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJG8</accession>
    <name>A0A011AJG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851770.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3263"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_8_11"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="560" mass="60895" checksum="45FD47B63CEE2793" modified="2014-06-11" version="1">MNTDQEQLAETPDIGGAYPRLSDEQIDLLSRRGEQRSVEPGDVLVAEGQRDRDFFVVLSGQVAVIEGYDSPKARPVRVHGPRRFLDELGLLTGQPSFVSMVAQEPGRVLAVPLPGLHELVREQPDLGNLILRSFLARRELLIGSIAGFKIVGSRFSPDTRRLRELAARNRVPHTWIDLEEDPGAEELLRRLAISATETPVVIWRDEVWRNPSSADLARLAGLRRSVPNNAMCDVVVVGAGPAGLAAAVYGASEGLATVVLDAVATGGQAGTSSRIENYLGFPAGISGAELADRAVVQAKKFGADLNVPVKAVRLRWHDSDQIVHLDDGTQLRTRTVVIATGAQYRKLDVPRLAEFEGTSVYYAATFMEAVFCERQPVTIVGGGNSAGQAAVFLARHAAEVRLIIRHDDLNRDMSRYLVDQIERLPNVGVLRHTEITELIGDDGRLRVLGLRDIRTGERQEIPTMLLFVFIGAQPCTDWLASSVDLDERGYVLTGAQVHTDAPQPVTLETSRPGVLAVGDVRSGSIKRVASAVGEGSMAVRLIHDHLARFGPAADRQRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJI2</accession>
    <name>A0A011AJI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3276"/>
    <dbReference type="HOGENOM" id="CLU_542760_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="436" mass="46243" checksum="6AF4718D267F2C5C" modified="2014-06-11" version="1">MPRPRLIARLDDAAAPVTVVSSPAGWGKSALLASWAAGRQDRAAWVAGGDRDGFWGRVVSAVTSTVGEPPFAGEVAAPTGPARLMEVLQRTSTMPVIVVDDCNDAADPGELVTLAETIRTSGTGTRLVVACRGVPNIPLHRWRLDGRLAEISGADLAFTVDETADLFAGHGLILPWPAVADVHARAEGWPGGLRLAAMALGHHPVPAEVFAGSAASEAVTDYLTAEVLCPLDPQARRALTEISVAERLTPDFVNAMTGRVDGAALLADLQRGGAFVTRCAGTEDTYRLHPMLSRTLYHELGRHDRERTVRAHHRAADWHAAHGPPADALRHLLAAGDWTSAIRVAHRHWAEIVVGSRCLDQLATAIPGPDGEAPRRLWFAMALERLDAGDVVGSRRFLGLARAEETAPAVGSAAEPLPFAALELTATRLEAALGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJZ2</accession>
    <name>A0A011AJZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570414.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143368_0_0_11"/>
    <dbReference type="OrthoDB" id="2060720at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="19157" checksum="7545369D8CBA6960" modified="2014-06-11" version="1">MDVRGSGNRHRSGWWPLRIAAATGLLHAAVSLFWALGGRWQLESVGDWAVQLADDHPVEAGLGLTLVALVKGAVAIVPLVNERRKTRYYRWIRFLGWSAGVVLVAWGGVSTLSAWAVLTGVITPTGGYDRETMIGHGLLWDPLFTIWGCALLIGLWCSRNRTHVTTEQTSRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKK1</accession>
    <name>A0A011AKK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3657"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="160"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="30634" checksum="82E72C9FE1EE4C6D" modified="2014-06-11" version="1">MREEVDMSDTTVVTVGVDGSAPALAALDWAARYAFAREATLDVVVAVGWPGERQFYGGYRVAELKDAAHVDGEKTLGRAVARVRTARPGLAVDGRVSDETAVRALLDASALSDLVVVGCRGLNPAAGLVLGSVSTAVSAHAERSVAVVRADRVPGPEAPVVVGVAGSDWDEATLGAAFAEADRWAAPLVVAHAWSDVSRVGLFGSAAVPSWIEAREEADALVTGRLAGWRAKYPDVRVNTVVERERPAEMLLGLAPDAGLVVVGSHGRGGFAGMLLGAVARRLVHHADAAVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKN4</accession>
    <name>A0A011AKN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3693"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="29144" checksum="227A08C624462AE4" modified="2014-06-11" version="1">MPTSTDTDCVIRVDALSMLYPTKSGGTVQALDDVSLRVRAGEFISIVGPSGCGKSTLLRILMGLSRQTSGQVTFSPSEDTHRNQLGMVFQQPLLLPWRTVRKNLLTSPDLHRTRDAATRAKADELLVMLGLEEFGDRYPNELSGGMQQRVGIGRALMHDPRILLMDEPFGALDAMTRDQMGLDLLRIWESDRKTVLFVTHSIPEAVLLADRVVVMTPRPGRLADVVEVALPRPRRLENINTPEFGEIVLKIRKLLDSEHSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALT8</accession>
    <name>A0A011ALT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQQ-dependent dehydrogenase, methanol/ethanol family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyrroloquinoline quinone</name>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial PQQ dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852968.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4083"/>
    <dbReference type="HOGENOM" id="CLU_018478_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017512">
        <property type="entry name" value="PQQ_MeOH/EtOH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03075">
        <property type="entry name" value="PQQ_enz_alc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0634">PQQ</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="565" mass="61913" checksum="04D1230852088C57" modified="2014-06-11" version="1">MTIEYVDAGEAVDQARLTHKVAGGEVAPPVTENVTYERILEARSEPENWLTYYGAHDGQRYSPLDQITTENVRRLAPAWVFQAGTSGIIAGASTYSFEATPIVVDGIMFLSGWDGWVWALDAKTGTEIWRYKHAVPFDVSLCCGNVNRGVAVAKGKVFFVTANAHLIALDATTGKKIWDKVKGDVRAGESATSAPIVIKDMVITGSAGGEFGVRGHLDAFDLETGEHRWRSYMVPKPGEPGAETWPSDGEAWARGGGNPWLVGTFDPDTNLMYWGTGNPAPDFDGGVREGDNLYTDSIVAIDVDSGQIRWHYQCTPHDVWDYDSISECILFERDGRKLLGHFDKNGYFFVLDRTNGERISITPFVDRITWGAITRDGQVAAKVYPDEEGVPVHFYPGPAGAKEWTHASYSPRTGWFYVPVQDVGATATRRRREFKESIPYWGAGVQVDIEEAVGYVSAFDADGEEKWRWRNELPMCASTLVTAGDVVFAGEPSGEFNALDARTGEQLWQFQCGSGHHSSPVTYAIDGRQYVAVPVGWGGWAEGFLPGMLGAGHGSALIVFALPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALU5</accession>
    <name>A0A011ALU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine cleavage system T protein (Aminomethyltransferase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570705.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4093"/>
    <dbReference type="HOGENOM" id="CLU_011963_0_0_11"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="118"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="SO_alpha_A3" evidence="6">
        <location>
            <begin position="410"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="506"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="5">
        <location>
            <begin position="797"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="889" mass="95776" checksum="EC014C90C23736B9" modified="2014-06-11" version="1">MRARTGGRIDRGRTLTFTFDGETYTGHPGDTLASALLAAGRHTIARSITFGRPRGITAAWAEDSGGPVQIEEPFPEPMRPATTVELYDGLSARSLAGRGRLADVPDTARYDAKHHHVDVLVVGAGPAGLAAARDAARAGDRVALVDEQSEAGGSLLSEPETPGWVADTVAELAAHPDVLHLQRTTAFGTYDDGFVLALERRTDHLGAAAPKNVSRQRVWRLRARRIVVATGAHERPIVFADNDRPGIMLAGAARTFLNRYGVLPGRAAVVFTTNDSAYDAAFDLHRAGVRVRAIVDARTEIPAHLAEACDRARIWLVRGAVVTGTRGEDRITHALVGPDPIACDLLLVSGGWNPAVHLFSQARGRLRYDGTLGAFVPGEPVDGLTVIGSAAGEVVASKTLWRVPGPAEFQFVDLQRDATVADLRHAVGAGLRSIEHIKRFTTIGTAHDQGKTSGVLTTGIVAELLGVPVEAVGTTTFRPPYTPVAFAALAGRDRGHLFDPERYTALHDWHVAAGAVFEDVGQWKRPRYYPRPGEDMPAAVLRECAAARTGVGLLDGSTLGKIDVRGPDAGVLLDRLYTNLMSSLKPGMVRYGVMCGVDGMVIDDGTVLRLADDHFLVMTTTGGAAKILDWMEEWLQTEWPELRVHLTSVTDHWATFPVVGPRSRDVVGAVFPDVDVSREAFPFLAIRETTLDGVPVRLARISFSGELAYEVYVSSWYAVAIWQRLLDAGRPHGLTPYGTETMHVLRAEKGYPIIGQDTDGTVTPQDLGMAWVVSKKKADFVGKRSFARAANLDPLRKHLVGLLPLDRRTVLPEGSQIVERLTEPPVAMLGHVTSSYRSAELGRPFALALVKGGRERVGEVLQVPVDGTLVPVEVTGPVLVDPEGARRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALZ7</accession>
    <name>A0A011ALZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4167"/>
    <dbReference type="HOGENOM" id="CLU_000445_34_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="1419"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1551" mass="166945" checksum="5A6091BED0395EC1" modified="2014-06-11" version="1">MTRTLIPDGSGVIRKEYFGADAARRLDTERAVLERLVGVPGVAQLAGHTSGYLELHDDGGEALGGVDVPTLLRLAPRLADAVARMHARGVTHKDLNPANIVLAGDRPTLIDFDLATTFAEERPAFTAEREITGSLPYLAPEQSGRTGNPIDQRTDLYALGATLYELATGEPPFGSGDPMRLIRDHLTRTPEPPSRRNPAVPAAFSAIVLRLLEKEPDRRYQSARGLLFDLRRVLDDPGARFPLGQRDFPLRLAAPSTLIGRTAEVTALRHAFTAGDTPLLLVSGECGAGKSRLIDELRPTVAAAGGWFVGGKFDQLRLDPAAGGAVAAIRAVGRLLLAQPEAELEPVRELLRERLGRAVDFLAPLPEFCVLLDKQDAPASTDPATIRAQLLHAAIEILRTVARPQRPVVVVIDDVQWSGPAPLELLDRLAGDAPIPGLFVVVAYRSDEVDEAHPLTPLLTRWQSRGVPRIELRTLAPGDVGELLADMLRMERDEVGDLAAEITAYTGGNPFDTVEVINLLRRDGVLELDERGWTWDPDVVRRSVHLRGPADVVAAHLDRLPDDTAAILEVLGCLGGEVDADLLTDATGLAGPVLTDRLRPALEDGLLVADPSTGAVRFAHDRIQQATRARLGHRDDAGFRLAVARRLAAVPRWTAAAAAQYLAVLGALTDPAERADVAALCRRAAAHALSTSNYVTVDRLLAAAESLAGLDVDLATQRHAALYALGRPADADRVYDWLLAQDDVSPLARLDATCVQITSLTNRRRTPEAVALGFAYLRTLGVDVPGDLGPAVTAGLERVDAWLAAGGPEADADRPEADDPSVAAIGALAYRLIPPTHFLDRSRMHWLVLECARLWIEHGPSPALIGALGDLTVVAGDVRGDHRFGRRLLPPLIAVGAARGYEAGTAKARFLYVMSTGHWFDEPRAHVVLAREAHDELVRCGDLLSAAFTYLVSVTLLLGHAPNLHEVANEVNDATAYGARSGNDQVTGFVQHYDTLVARLRGDDTPFGPPPDDLHEVVGYHLTQAFLAALFEHPDALSAHTAAVTGPLPNLAGMPMMLDAHFLRALALIWDGGDRAELAAERAWIAARAADAPQRFAHLPVFLDAELAAVRGDVETARTAYDEAVRRAAAGTSRWQRAWFAERAGRFAVRTGLPYGGALLLERARAEYTIWGAQAKTAHLDAEFPELAGTVRPDPRASNRLSSGALDLLGVLSASRALSSETNLERLRRRIVDVLGSVSGATTVEVALHNDGDWAVLGADGARIPVDEAGDRLPLTAFRYVRRSNRPLLVDDATTDERFGSDPYVAGQERCSLLVVPIEYRGAPWAVLVLTNTLSTGAFSADRLDAVTLIAGQLAVSLDNALLYTSLEQKVAERTQELAEANRRLEQLSLTDPLTGVANRRRLTEMLDAEWSRAGRTGEPLAVAMLDIDFFKLYNDHYGHPAGDECLRTIADTLGLQVRQSDVVARYGGEEFAVVMPDTDVKGAHAVAFRMAGAVAELRLPHERTERGHVTVSIGVASATVAVGGTPSTLIDAADAKLYEAKRAGRDRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM20</accession>
    <name>A0A011AM20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4192"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="421"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="461" mass="51024" checksum="19481A0477FC593D" modified="2014-06-11" version="1">MQFPAEFVFGSATASYQIEGAAQEDGRGPSIWDTFSHTPGKVLNGDTGDVADDHYHRLDADLDLMVELGLEAYRFSIAWPRIIPAGRGAVNQAGLDFYSRLVDGLLARNIRPVATLYHWDLPQALEDEGGWTVRSTAEAFAAYARVVGEALGDRVHTWTTLNEPWCSAYLGYSSGVHAPGRTEPLAALTAVHHLNLAHGLALRELRQVVRPDAEFSVTLNLHVFRPVGATGEEARRRVDALANGVFLGPMLEGAYPADALEVTSGITDWSFVRDGDLEIIRQPIDVLGVNFYSTNRVQLWDGSGERQRADGHGASSATAWPGADDVEFLATDPPHTDMGWNIDPQGLEDLLVELGDRYPDQPLMVTENGAAFPDVVTDDGHVHDADRTDYVRRHLRAVANVRAKGVDVRGYFLWSLLDNFEWSYGYSKRFGIVRVDYDTLERTPKDSARWYASLIRSRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFL7</accession>
    <name>A0A010YFL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569522.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="24789" checksum="C94D7591971B4E13" modified="2014-06-11" version="1">MPRSRPAERYRARIAVVGGDRDPGLHRTAGLLESEPSFDVRTDHVAGHGAGRDRLALLDRTQPDVVLVGRFPGRPELTALMAREVVDAAGRPSRLIALAAGPPDAELRAVLRAGAIGFLRADARRTTVLEVILRAAEGAVPSSPAATTTLATAFAAPPRQPGSGARLSQLTRRERDVLRLVAKGLSNGEIAAALVVTTSTVKTHMNAILGKLGLRDRVQATVFAYESGLIRPGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH84</accession>
    <name>A0A010YH84_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848405.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.667"/>
    <dbReference type="HOGENOM" id="CLU_130902_0_1_11"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="13148" checksum="ACCDC4320194B39F" modified="2014-06-11" version="1">MRYLTLLRGTHSTTPPPPELMAAIMALGEEATKSGSLLENSGLAPSSAGARVSLSAGELTTTDGPFAESKEVISYAIYEVNAKEEAVEWASRFLKVHRDLWPGWEGDVDVLKLFGPEDFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI32</accession>
    <name>A0A010YI32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569756.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432373_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457600" evidence="2">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="19315" checksum="E858CA8A8162A4F6" modified="2014-06-11" version="1">MNRGSPLALVVALVLCLGATAVGYVHTQPDAYTSTSVLSLSPRDPGEVGSDDLTLATSRYVAYLSAPATLDALSGTLGVRAATTAKSTTVVQQPGTVNLRISVTGPDARDGAEIANALARAGVRQSVDDDQVVVDLIVPAVVPSAPSGPPRTLLYLVSGAGVLCLAVLALLALGYARPREREVVEVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIU2</accession>
    <name>A0A010YIU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1206"/>
    <dbReference type="HOGENOM" id="CLU_020215_2_0_11"/>
    <dbReference type="OrthoDB" id="1239213at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="422" mass="44540" checksum="C4447BA4EF5EF232" modified="2014-06-11" version="1">MTVVIGAGASGVLTAVALAARPGGPVTVVESAPDVGRGVAYSTTDYGHLLNSRTETMSLYADRPGHFLEWCRERGLYCGPAGYAPRTTYGRYLGEALENLVRGSAGRVRIVRGRAVAASGTGVTLADGRVLPADDVVLALGHPPARTADIDPWTSGALDRVGRHDDVVLLGSGLTAVDVVVTLAGRGHLGRVTAISRHGLLPRVHVDPPPRVVPSGVSGHTVSALIRQVRRAVPPHGEWRGVVDGLRPDVERLWTGMTVTEQDRFLRHVSRLWEVHRHRMAPPIGAQLRRRSREGRLDVVAGSIVATGADGVSWVPRGGGPVVRTAGAVVDCRGPGTWVASADPLARRLADAGLVRPDAHGLGYATTDDGQLVGADGTVVPWLWTLGPVRRGSRYETTAIPEIRAQATTIAERVTSALLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIW1</accession>
    <name>A0A010YIW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848972.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1222"/>
    <dbReference type="HOGENOM" id="CLU_032013_1_1_11"/>
    <dbReference type="OrthoDB" id="228571at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36250" checksum="FDD6C8530DB0DF1E" modified="2014-06-11" version="1">MPSFDFQPDPDVDPAGLVYTFGGVAPVASLTPGTVLTTWTRDCFAGVVRSVDDRSSELCDPRYLNPQTGPFHIEGAEPGDTLAVHFISIEPRETWGVSTTVPFFGSLTATPVTPLLHPALPERTWIYDLDRVARTVRYRALDSDFTVDLPLDPMHGTVGVAPALGEVRNSLAPGDWGGNMDTPEMRAGVTCYLPVNVEGALFSFGDGHARQGEGETCGVAVETAMDTALVVDVIKGHPCRWPRIESDDFLITTGSTKPLEDAFRIAHSELVGWVAAEAGLSTLDAYQLVSQATLTPVANVVDTVYTMTAKMPKSALPGVVAMGGVHARLRALGAAWLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK12</accession>
    <name>A0A010YK12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569919.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1635"/>
    <dbReference type="HOGENOM" id="CLU_024336_0_2_11"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457612" evidence="3">
        <location>
            <begin position="32"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="155"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="5">
        <location>
            <begin position="266"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="545" mass="56057" checksum="C1CD52CC0A7FF5B9" modified="2014-06-11" version="1">MPLSDFRPRRALVALTAATTLALAAATPAAAAPPDPGAALSKKLTSAVTTEGVFGHLRQFQKIADANRGTRASGTPGYDRSADYVARKLQHAGYRVSRQSFEFPYFQELNPSKFSQVSPAPKTFVNGTDFETLSFSGDGAAQGTVTAVDVNLTPPRASTSGCEATDFANFPKGNIALLQRGTCDFGVKATNAAAAGAVGLIVFNQGNGTEAANPDRFELFEGNAGGPVPIPAITVPYALGAQLAGTTNTVVRIETDTLSETRTTQNVLAETPGGRADNVVMAGAHLDSVPEGPGINDNGTGSAGLLEVALKYAPLAKKSPNKVRFAWWGAEEGGLLGSAHYVSALTPAQVADIGLYLNFDMIGSPNYLLAVYDGDNSTGTGTPPAGSGALETIFRKYLASRGQQVVDTEFDGRSDYGPFIAEGIGIPAGGLFTGAEGKKSAADVAKFGGVADVAYDPCYHQKCDSLSPKKDGADAAVYQRLTKAYGKKLVGNINVFALDLNSDAIADAVARLAWNTSGISEPGDAPKAAAAAAPSGGGQGPVPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK89</accession>
    <name>A0A010YK89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849639.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1704"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="30541" checksum="E090BCEA819D4211" modified="2014-06-11" version="1">MQREQLADFVRRRREAIRPAQVGLADGPRRRTGGLRREEVAMLAGMSVDYVVRLEQGRSSQPSPQLLGALARALRLSDDERDHLFHLAGQPPPPSDGVARLARAGLLRLLDLLGDNPAMVISDLGEVLAQNRMSTLLVGDQTGHNVLLRWFAEPAARAAHTPAEQERHSRQHVADLRAAVGRRAGDPEVAGLVARLEAVSAEFRQLWSEHEVAVRRADRKTLVHPRVGPLLMDCETLVTPDLGQQLVVLTPADADARERLDLLRVVGLEEFPAQAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL63</accession>
    <name>A0A010YL63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase FliI/YscN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861609.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2035"/>
    <dbReference type="HOGENOM" id="CLU_022398_5_1_11"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="170"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="450" mass="47369" checksum="83A9386ACD5CCDE9" modified="2014-06-11" version="1">MSRLLQHRLAPAIRAAQPEVTGRVDSVLGLSVSVVGVPGRVGDLVRIGGIGGMAGIRSGSGRGDNTTIAAEVVALDGARLSCLPLGPLGGVGAGDRAVNTGSPLQIQVGESLRGRVLDGLGRPMDNGPPLVNTEWVSVEGEPPTAMERGLIRFPLPLGVRALDTLVPCGRGQRIGIFAGSGVGKSSLMSMITRGTEAEITVVALIGERGREVREFLEHDLGPEGLARAVVVVATSDTPPLVRLRAGFVATRIAEWYRDRGKDVLLMMDSLTRTAMAQREVGLSAGEPPATRGYPPSVFALLPRLLERAGPGSAGTITGLYTVLVEGDDQNEPIADTARSILDGHVVLDRKLATSGHFPAIDVLESVSRVSGAITTREQKAMASELRRLMAAYRDVRELLEIGAYVPGTNPDADRARELWPAITAFLRQSLGDPYPAGAAWDAMAQLLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLJ1</accession>
    <name>A0A010YLJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850268.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2158"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="360" mass="37772" checksum="E906D0B7905250BC" modified="2014-06-11" version="1">MRSVQRWLGADAALVAGCLFLTVLAVKTPWSDLPPVVVAVAGALASLAQWWRRRWPGAAAVAGALGYALSGNPGPLLVGLYAAGAYAPRRHAWWLVAVGWAGATGWNWLDAGRLSWWDAAYVAVAAAATFGLGAYVATRRALQDAWRERAERADTERTLRDEQARIAERARIAREMHDVLAHKVSLIALHAGALELTADGGAERVREGAGVIRVTAREALAELRTVLGILEADAQPYTDLASVVADATSAGQRVQLANTAGELPASSARVVQRVVQEGLTNARKHAPGETVTVSVGRDADVVSVVVTNPVTGVGLELPGSGAGLVGLAERLRLVGGALESGPTPDGWHLRATIPYPSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLR4</accession>
    <name>A0A010YLR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsI/penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850368.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2238"/>
    <dbReference type="HOGENOM" id="CLU_025328_0_0_11"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457888" evidence="2">
        <location>
            <begin position="26"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="5">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="150"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="353"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="625" mass="64698" checksum="9D99CEA4DDABD681" modified="2014-06-11" version="1">MNVLKGRAVLAALGVLAAVALTACSADNDPEPAVDAFLKNWRQGQLGKTSFVDPDGKSVPAADVTAQLTKLTGELAAAPTKLERAGDAKVKDGRAVSPVQVTWTLPGPVTWTYRTDVRLRERDDTWDVTWEPALVHKKLKAGDTLGTKREEAPRSGILDHTGAPIVSPRPVVSVLLDPAKVTDPAAAVKQLGAAFATIDTEVDLADLPGRLAKAKPGIAVDVVVLRQEAYDKIASRITAITGATVVKSTRDLAPTRQFARALLGSVSDATEEDIKEKPGLYAVGDHVGHGGLQSAFDQRLRGVPGVTVVVNPAGTALFTSAPKPGVAVRTTLDQRVQTAADAALADLPQQSALVAIRISDGSVIAAANGPDGGSFNAAFEAKVPPGSTFKMVSTLGLLDQGAVTADATVACPSHLAAGGREFKNFDDFELGDVPFRTDFAKSCNTAFVALAPKLGPDGLADAGRLLGLESKYGLGLPAFSGKVSTGGDAAERAAAAFGQGRTVVSPLAMASATAAVASGRWTPPSLTGKSAVAPGPQLKTTTVEPLRAMMRQVVTDGTATSLRDVPGSPVYGKTGTAEFDNDPEHAHAWWVGWQGDVAFAVFVENGGHSSSVSVPVAEKFLRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLU5</accession>
    <name>A0A010YLU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of Mn/Zn ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850406.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2263"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21054" checksum="DCF0F620E59542A7" modified="2014-06-11" version="1">MSAVVSTEGVGFRYGGVPVLSGVTLGVEAGSMLAVTGPNGSGKSTLLHLLAGVESPTEGRVRRAGGARLSLLPQRTSDIDALPLTVAECVRIGRFRPLRRLGRADRLAADTMLDRLGLADLAGRRLRELSGGQRQRTLLAQALVQDAEVYVLDEPTAALDAASRQRVHELLAERRAAGAAMVLASHDAAESALADELLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMI8</accession>
    <name>A0A010YMI8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2515"/>
    <dbReference type="HOGENOM" id="CLU_048247_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="37246" checksum="213579ADF2BC2EEE" modified="2014-06-11" version="1">MPMNGDTTSLASTRAEPGGARRMSVRRTVPIVVVAAILVVEAIVGWSSLTAAFDELHTPHWGWVTLAVVAELVSMGGYARMQRRLLRSAGTTVHLGRHVALAFAAHSLSVSLPGGPLFSTRYNFQQMRRYGASAAAASWCIALSGVLSSVALVLIGAAGALLAGSGGGLSTLMTYLVVGLALALAVRAMARHPQWLTTVAGAIESVAARVRHRPGGRSGRLVALVDELTSVRIRPFDLAVASYFALANWLLDALCLWLCCRAVGAPHITVVALVLAYCAGMAAASIPLVPGNLGVVDGALIVGLVAGGLVTSTAIAAVVLYRIVSLGFIITAGWIVWLLIRRRQRRDPLRGPATIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP93</accession>
    <name>A0A010YP93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570280.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852094_0_0_11"/>
    <dbReference type="OrthoDB" id="1900996at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="375" mass="39958" checksum="6D532F4D9BF6EA25" modified="2014-06-11" version="1">MGSWIVDSLLTWFAQTVVGILNTLWDLLATTVFVSPDVTVLPQVTAFARTSTNIVNGCYVLAFLWVAILVAGRGTIQSTVGPGELIPRLIVGLIAANFATQICAAVIQGSNALIVALTDRPIAGNGAVQQLRDLTVAALTSDDVTSPGGFLLLAIGVIIAVLTGMLLVQWIVRLGLLIVAVGVAPIALALHGIPQTDALAKTWWRTLLGALTVIVLQAVALHLTLSILLDPQANLPMLGLGDDTGEVINLFVILCLLLGIIRIPALMRRFVAQPRTSTIGTIVRVAVIQQLTRNAQRVLSRAVAPTRDRSNHDGTWLLLTRPSAQRPLPRPSGAGPGRVGVAYPTGRPVRPYTREELAGGVDVYTRALKRRGDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPX8</accession>
    <name>A0A010YPX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3354"/>
    <dbReference type="HOGENOM" id="CLU_027853_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="31410" checksum="8DBEDCB969A5B535" modified="2014-06-11" version="1">MLNNLLRFGLSLDPDAARADDAVRLAAAAEEAGLDYLAVQDHPYQAGHLDSWTWLTHLAARTSRIGLLTDVADLQLRPPAMLAKAALTFSRLHHGRLALGVGGGAFPDGIAAMGGTRRSNSDMVAYTEEAFQVLRPALAGDFVRLHGAHHRIEGYQAGPAPAGPVPVWLGAQGPKMLAVTGGYADGWISPLNIYVKPDEVPAKQKIIDEAARAAGRDPAAISRIYNVIGWIGSDRRAPGLSGDVEQWVDTLADWSTRLGFDTFIFWPVAQPQAQLELFAGEVVPALRKRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQF3</accession>
    <name>A0A010YQF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2768874_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="69" mass="7775" checksum="D3F1F55C54F72EF3" modified="2014-06-11" version="1">MSANDYERLEQGHSRSVRWARPTTRPPISAAGRHLDALGWMGVGFPLPSELTGWDRRTRSGPELPAYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQQ8</accession>
    <name>A0A010YQQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3697"/>
    <dbReference type="HOGENOM" id="CLU_028871_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458132" evidence="2">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="41"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="359" mass="37836" checksum="8733D74384214988" modified="2014-06-11" version="1">MKTRRAMKLVSGAVAVLCAAATLSACGSDDSASSGGLTPVKFAMASPSWNAGFAVMAVVEAEGFYQEEGLKVTTNLFPSATQAAQQVAGGGADVGLMTVEPVAIGHDKDLDLAYFSSYWPKWIYSLQVPEGSDVKSIADLKGKKIGVTAVASSGATFARTAMKLNGMSENDASLVPIGAGPQQINAIKSGQVDALALWDIQYQSVKNAGITLTPLPVTETADAWGGGFATTRKNLGAKKDVLERFGRAVAKAFAFSKANPEAAVRDLWKLHPETRGSGSEAKALADGVKVLQVRLEGQGFDDKTLGRIDEAAFTRSLDFLASADLIKKFPAKDVYTDELFTAFNNFSYEDVVKRAESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR75</accession>
    <name>A0A010YR75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase, G3E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852632.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3864"/>
    <dbReference type="HOGENOM" id="CLU_017452_1_1_11"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="347" mass="36953" checksum="6C655D65C54AEF4A" modified="2014-06-11" version="1">MRGGGRVPVVALTGFLGAGKTSLLNHLLRRPGARLGVVVNDFGALNVDAALVTGQIDDAAAISGGCVCCLPDAGGLDDALRRLAQPRLRLDAILVEASGAADPIAVARLIGFSGAKGIRPGGLVEVIDAVEHFRTVDRWPEPPARYGAATLVVVNKADRLPGDDREAVLARIRERVRRRHPQVPIVTARYGRIDPALVFDTAADEDPADQLPIARLIREQDAGRAGHDQDHDHDHARAASVRLDRPVSPTALIDLLEAPPTGAYRLKGRVRVHGSRAEQGFAVDVVGSLIHVAPLPEPPPVGELVAIGMELDPAGAQQRLDAVAATPAERPDTPGLRRLRRYRRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRP3</accession>
    <name>A0A010YRP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725735.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4061"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_4_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21929" checksum="73AA2068B404E4CD" modified="2014-06-11" version="1">MSARASIGSVTDITSLRERRRLATAAEIEAAALELFACGGSEHTTVDDIAAAAGVSPRTFFRYFPTKEDAVLGVKRDFYAAVSERIPPGAIGFDDLAGATAEALESFSATFLHRMVRVRCLGEHDANLRHRALLLDAEQCRQRQRHLGGDMHARLLVETLAVALNTALDDWAIRRHHGEDADLAGVFRATCAQQRALFQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVJ5</accession>
    <name>A0A010YVJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859934.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.178"/>
    <dbReference type="HOGENOM" id="CLU_114123_1_1_11"/>
    <dbReference type="OrthoDB" id="1735593at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15243" checksum="C7D5858DAF27B1A8" modified="2014-06-11" version="1">MSAATPGGLAVVFVALYAAHQVADHWVQTQHQADHKGRPGWVGRIACFLHVATYTATALVALLAAAWRTGLELSPAATVAGLLVSAVTHYIADRRTPLRIIADRIGSGPFYRLNTAGMNGAYLLDQSWHIGWLFVAALVIGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWA9</accession>
    <name>A0A010YWA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848077.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.452"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="30763" checksum="37AE143E83424A99" modified="2014-06-11" version="1">MTVLVTGATGRVGSLVVENLTRAGVPVRALTHRSEAVATMPSDIEVVTGDLTVPDSLEAALRDVSAVFLVWTAPPETVPAVIERLAAQSCRIVFLSSPHRTPHPFFQQPNPMAALHDRIERLIAESGAESTTIRPGMFASNAFAWWAPAIRAGRSVRWPYGSAETAPVDDRDVAAVAARTLYRDGHAGGDYVVTGPESLSQAEQVAVIGDVLGRPIEFEELSPEEFRRETAGTWPPSVVEMLLAAWGATIGRPAFVTSTVLDVGGSAPRTFRQSVADHAAEFTSSPANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWM3</accession>
    <name>A0A010YWM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanosine polyphosphate synthetase/pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086331_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="26994" checksum="523448C4386EFFF7" modified="2014-06-11" version="1">MEGGEGHPFCRYFGAGVHARKGTRWPSLSCVALTTSNTLVTRPWQAELMLLRVRVSLPDRPGALGAVTRTLGAAGADILQVTVLESVVGRALDEFTVSVANPAVRERVAAGLEAAPGVRVEGIWETVEPPGALSDLGVLSQIAANPGRGLATLVDAAPALFSAGWAALVETEPSLTVIRTSWQAPETFTYPELTPLRPRTLSVPDGPHLAVTPFDGTTTVLVIARHHAPAFHDVELTRLTVLADIVGAIVGKEALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXG3</accession>
    <name>A0A010YXG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.906"/>
    <dbReference type="HOGENOM" id="CLU_006462_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="73"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="637" mass="72330" checksum="0671555199D497BF" modified="2014-06-11" version="1">MLTIEYGGQSVDVRLSPGRNLFVSHTADGTIGRDGIRVLTALGDVFDVHPKREDLAEESRPPTDWHKRAVFYEVPVRAFADTSGDGTGDIAGLISKLDYVSWLGADCLLVGSVFDSPMRDGGYDVTDFRAVQPLYGTMRDLVELLGEAHRRGIRIVLDLPLNHTSDQHPWFQESRRDPEGPYGDYYVWSDDDSKYADARVLLVDTESSNWTYDPVREQFYWHRYFSYEPDLNFENEAVQEAMVDVLRFWLDLGIDGLRLDGVPFLFEEEGTNCENLPRSHDFVKRYRRVVDEEYPGRILMTGANQWPADAVEYFGRASTIALPHPPRLRGTSPPARAGGSVSHGECHVAFHFPLMPRIFMAVRRQSRFPISEILAQTPEIPEGAQWGIFLRNHDELTLEMVTDEERDYMYTEYAKDPRMRANVGIRRRLAPLLDNDRNQIELFTAMLLSLPGSPVLYYGDEIGMGDNSALDDRDGLRTPMQWAPDRNAGFSVCDPGRIYLPVIMDPIYGYQVTNVEAQLGASASLLHWTRRMIEIRQQHQAFPLGTFTDLGGSNPTVLAYIREYVDADGEHDIVLCVHNLSRFPQPVELDLGRFRGCTPIELSSQVHAPPIGELPYLLTLPGHGFYWFQLTPHEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXW0</accession>
    <name>A0A010YXW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848816.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178345_3_0_11"/>
    <dbReference type="OrthoDB" id="2098134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="6943" checksum="F4D3313C3524DAC0" modified="2014-06-11" version="1">MLPPTRFLVRLSCRPRGDRGDVPGWVMVTVMTAGLVAAVFAVFREAIVVAVQNALDQVVSDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYM1</accession>
    <name>A0A010YYM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849128.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169117_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="24729" checksum="A39E0FBDDCAD1C93" modified="2014-06-11" version="1">MTGLPATPARLPEVRAISGRVLMGFAIPVRVSKGSASLARVSAALAMVGQVLAVRVMVGRALVGLVTVIRVLAVLSTSARLPAGPVMVLRAAVGSAMLPRILAALVLVVPVMVGFVTVVLVIQGCVRWAAGRVASRLGVSPSRLVASRVPVRAIRVFGTPAIAGPPSANPACVPVLLATDSRARAVRVSVAPWRVSRAIVALSRAFRWTVVHSTVSRMTVVRVSEVLWRASRVPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYZ7</accession>
    <name>A0A010YYZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849336.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1496"/>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_11"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="30410" checksum="4634F30CB70E3C24" modified="2014-06-11" version="1">MSILHYDFMVRALIAAVLVGLTAPAVGIYLVQRRMSLVGDGIGHIALTGVALGFLTGQSPVLSAVVVAALGAVAVELIRSRGGASGDVALSLLFYGGIAGGVLLISLAPNGGNNNLLGYLFGSLLTTRPSDLIVMGVLAVAVLLFTVGLRSWLFAICHDEEFARVSGVPVRLLNILLAVSAAVTVTVAMRVVGVLLVSALMVIPVATAQQVARGFAATLAGAMGLSVAVALTGAVGSFYLDVPSGASIVVLAVLVFVVVTAVAAAVHGWQRRAAARPSRPAPEAPAPDPVAAEPTGAGVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z089</accession>
    <name>A0A010Z089_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849981.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1927"/>
    <dbReference type="HOGENOM" id="CLU_086567_0_0_11"/>
    <dbReference type="OrthoDB" id="1469969at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="27522" checksum="65856ECFAD97CAB3" modified="2014-06-11" version="1">MTASDAARRGGRNRNRAGRLGRAVMLVVALGLIGGAYATFAPTGQADETSSSIAVREGQKLYNESCITCHGQNAQGVKDRGPSLIGVGSASVDFQVSTGRMPAARQEAQVARKQPAFNDEQTDQLAAYIQSIGGGPEIPDGNLRGDEALGGELFRVNCSSCHAFSSNGGALSSGKYAPSLEPSSDRDIYAAMLTGPQNMPVFGDNQLTPDEKKAIIAYVQTQKTDADPGGWGIGRTGPVPEMVVIFAIGIVVCLFGALWIAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0W9</accession>
    <name>A0A010Z0W9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">CryarDRAFT_2183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850253.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2149"/>
    <dbReference type="HOGENOM" id="CLU_088964_0_1_11"/>
    <dbReference type="OrthoDB" id="1402654at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="22542" checksum="F3DF0F11D2CF2756" modified="2014-06-11" version="1">MPHLLHLDSSADLTGSRSRAITAAFAKAWADRGADHTITYRDLHTDPLPRLSATALHWAPRLRAEGETAPAEDEARQRMVLDELLAADVLLVGAPMYNYSLPSTLKTWVDHVHVPGVTTTLDDTPSQPLAGRPAVVVTSAGGSYAEGSPTAGWDHLTPVLRIILGDALGMTVTVVATELTLAPRIPDLAPQVPHSEALFAAALDRATALGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z161</accession>
    <name>A0A010Z161_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850372.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2241"/>
    <dbReference type="HOGENOM" id="CLU_016755_1_3_11"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="354"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="468" mass="47893" checksum="22248D5847788EA5" modified="2014-06-11" version="1">MFDVIVIGAGPVGENVADRVARGGLSVAVVERELVGGECSYWACMPTKALLRSTAALRAVNRLPGAREAVTGPVDAAAVLARRDSFASNWADDGQAAWLDQAGARLFRGQGRISGARAVEVTAADGTVTSLTARHAVVVATGSSALVPDVAGLRAAAPWTSREAAATTVVPGRLAIVGGGVVASELATAFAGLGSAVTMLARDGVLPAAEPFAGELVTGALRDAGVSVRPGAELRSAERAADGTVRAALTTGETVEADELLVAVGRTPNTSDLGLDRVGLTPGGWLRVDDALRVVGVDGWLYAAGDVNRRALLTHQGKYQARALGDAIVARAAGGAVDHGRWGRHAVTADEAAPQVIFTEPEVASVGLTAAAAEAAGLPIRVVDHDLGAVAGAAVHADGYRGRARMVVDRDRNVIVGVTLVGPDVAELLHAATIAVVGEVPLDRLWHAVPAFPTISEVWLRLLEAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1C0</accession>
    <name>A0A010Z1C0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850464.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2296"/>
    <dbReference type="HOGENOM" id="CLU_081279_0_0_11"/>
    <dbReference type="OrthoDB" id="1642505at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="24779" checksum="4A0A19B995358F9E" modified="2014-06-11" version="1">MRPARIALIGDRSPHVLAHGRIPDALRQAAGEREVDVYWIASTDAARLTGLAGFDGIWAVPGGPYVDRDGVLHAVTVARTSGVPFLGTCGGFQHVLLEYARSVCGLDVEHAEQPLDAGAEPLIVALHCSLLGEEADVIVAPGTRAAQVLGAGRRVERFFCSYGLDDRFRARLEAAGLVFSAVDDEGTARMVELPGHPFFLASLFQPELSSDLHWAHPLIHAFTDAALAGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1D0</accession>
    <name>A0A010Z1D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A/acetone carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850474.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2301"/>
    <dbReference type="HOGENOM" id="CLU_002157_1_2_11"/>
    <dbReference type="OrthoDB" id="327092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="214"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="703" mass="74064" checksum="548116666EA8C03B" modified="2014-06-11" version="1">MAYVIGVDVGGTFTDAVLDDDSGNLVAAKAPSTPPDYSQGVMDVLAVLAENLGEPLEQMLAKTHHIAHGTTSSLNALVMGNVPPVGFITTQGHRDSIFIMNVEGRYLGSSPDQLQNVLGQTKSHTLIPKRHAVEVVERLDRDGTVIVGLDEQSVRVAVRGLLDQGIRSIAVSLLWSFKNPTHEQRIRELVHEIDADVFVALSSEVSPRIREFARSSTTIMSAQIGPGLRSYLGTLEERLRAEGLTGPLLVMQSNGGAIAAAEAPRAAISTVGSVLTGGVVGAVSLGQQLGHRNIISTDVGGTTFLVGLVVDGEPVRTSTTVINHHPINVPTLEVHAIGSGGGAIAWIDAGGNLRVGPRSAQSVPGPACYGAGGTEPTNTDANLVLGILPESGLLGGRKALDLQAACEAIRTKIAEPLKLSVEDAAAAIYAIQNAQTGDLLRKTVVEAGHDPREFVLYAFGGAGPAYCASYAAEVGVREVVVPLGPVASAFSAYGLASSDIVLAREVSDPGQMPLPAAQVQRHFDELEATLAADLERQGLRYNRIEYVRSIDLRYTSQLAEVSVTVPEGRLDDGAMSTVAKDFERRYAELFGEGTGFSAAGIQAITFRVRATGILPFNPQLPKLADADTPDPAAARSDVRKICLDPRQGYVDTPVYDYRALRHGHVVAGPAVIEVPTTTVVVPPGMSGTVDHLGNLTITTETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1J8</accession>
    <name>A0A010Z1J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850559.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924086_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="13869" checksum="D8561DC6DEE15BA6" modified="2014-06-11" version="1">MSPRPDVLAPLVSTDGTLDVSRAVDEANHWALFQLSGTLDEGSAPQLLELLVAAARVDAVDLVIADLLQVPWIGGPGARCLEAGARATGRHGAQLVLTRPTLFVRRVLEVVGLAGLVTDEAEAGWHWSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1L8</accession>
    <name>A0A010Z1L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(P)ppGpp synthetase, RelA/SpoT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2382"/>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_11"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="463"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="728"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="803" mass="87588" checksum="334E4AF37FD083BF" modified="2014-06-11" version="1">MSDVAPTVAGGQRDPVPAPGPDAAAPSGALPHADSAVAAVSANGSGAEPGGIGAPTGRRVRAALARFSAPSWQGAVNVVLEPLVATHRGAHPKADVRLLQKAYDVAEQFHRGQLRKSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTGYTLEQLHADFGGEVAHLVDGVTKLDKVQFGDAAEAETIRKMVVAMARDPRVLVIKLADRLHNMRTLRFLPRPKQEKKARETLDVLAPLAHRLGMNTVKWELEDLAFMTLYPKRYEEIARLVQEHSPARDRGLADVTSQVQNDLKNAKIRATVVGRPKHYYSIYQKMIVRGRDFADIYDLVGIRVLVDSVRDCYAALGVIHASWQPVPGRFKDYIAMPKFNMYQSLHTTVIGPEGKPIELQIRTLAMHRTAEYGIAAHWKYKETKGAEVAGPPATVDDMAWLRQLLDWQREASDPGEFLEALRFDLGGQEVYVFTPKGDVVALTKDSTPVDFAYAVHTEVGHRCIGARVNGKLVPLESTLNNGDTVDIFTSKSENAGPSQDWLSFVKSPRARTKIRQYFAKERREDAIESGKDALQRVMRKQGLPLQRLLGGDALLTIARDLHLSDISALYAAVGENQVSAQAVIQRVVASLGGAEGATEDLAETARPAKHRSRPAGPGDPGVIVSNAGDDVWVKLAKCCTPVPGDSILGFITRSGMISVHREDCTNASDLKAKEERLVEVSWAPTAGSTFLVAIQVEALDRHRLLSDVTKVLSDEKVNILSATVSTTRDRVAVSKFTFEMADPKHLGHLLRVVRRVEGVYDAYRVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1U6</accession>
    <name>A0A010Z1U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570076.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2473"/>
    <dbReference type="HOGENOM" id="CLU_013382_0_0_11"/>
    <dbReference type="OrthoDB" id="1643926at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458232" evidence="3">
        <location>
            <begin position="31"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="724" mass="73039" checksum="D66D26CDDB6A8B4C" modified="2014-06-11" version="1">MRGHPRLVGGLVGAAAAVVAVLLTPSSVAARPATETIRSDAVIVVGVAGLQWTDVTADRTPTLAKLATSGSVGTLSVRAAPAVTCAGEGWLTLGAGRSSAIVEPSEIDTAEGCGPRTAPPVSARPKGSGAAVDGWEDLAALNRGLRFGAKPGLIGTRLNCTGAVGPGAALAAADSSGNVDVYRPALPADPGPLLRACPFTAIDLGILPDPAGYAARRAEALRLLDSALAQIEATRPVNSTLLVVGVSDTDATDGRLHVAIADGPGFEAGWLRSPSTGREPYLQLVDMAPTVLAVLGEAVPDDIAGRPVIRSDTERPGFDATREELVDADTAAVSRKHLVGTFLAGFAGLCAIVYGVAAWLIRRREPAAPARRHGAVAVTALGTFPVATFLANLVPWWAADPTTPALAGAVLGAMTLVTAVAVGPPWGRTATGRLAAISAITVLVLLADVATGARLQLNSLLGYTALEGGRYVGFGNVAFAVLGTAAVLLAAALATGRPARSAVAVALAVAVPVIVVEGSPGLGTDFGGILTLVPAFGVLTLLVAGRKVTTGKAAAVLGGGAALVAMLAIADYLRPEEDRTHFGRFVATVLDGNGLATVDRKIRANLDLLFAGPHTVVAALLLVVAAVAVFRPPAGLRVAYRAHPGLRTGLQVVVVLGLLGFAVNDSGIAIPVNAALIALPAAVAAWLRPYPPSKLGATTESAPDDEKTSDTPARSAEATADVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z204</accession>
    <name>A0A010Z204_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2535"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="465"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="680" mass="72429" checksum="C2A077484F407480" modified="2014-06-11" version="1">MAAPAVARAATSDDLDAVARAAAESVDVPIGLVTLVDGEWMRFAGAFGLVGALAESRRILVSESFCQDVVASDAPVVMRDTENDPRSRPTGAAVRVGAYLGVPLRARDGTAFGVLCAIDGRPRDWTPAEVGALRGVATAATNLPGLFTELPAETAPADGPPHSLFLQALLDSLNTAVFACDAAGYTMFGNPALQRMLDLAEELPTDAAAIAGDRLRDADGQPLPHDRHPSARALAGEPVRDVVLRLARPGRPPRTLIANAERITVAGAVLGAVVALHDATDQQRAQRFRECSLAVSRALVEADRVAEAARQVVDAVARSLHWPHAELWLADPVTDVLRPAASWTDGELDRPGLMSTALGPGEGLAGTTWQTGEPVWVPDIATETRFDVEGAARRKLRTALAVPVRSAEAVVGVLAIYADTLDEDRIALTAHLVGIAAHVGHYLERRRAEELALQLARTKDDFLALVGHELRTPLTSITTYAQLLSDNPDCWTSDGPQLLGVITRNTQSLTAIIDDLLDLAGLESGHITIRPSDTDLAELTREGIETVRVAADRREITVEADLPERVALHGDPQRLRQMLDNVLSNAVKYSHRGGRVTVALVEEAGVAKLSVADTGIGIPPDERDRLFQRFFRSSTARDNGVPGTGLGLVVTRAIVERHGGRISATHTDPGTTMVIRLPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z290</accession>
    <name>A0A010Z290_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit</fullName>
            <ecNumber evidence="8">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850910.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2623"/>
    <dbReference type="HOGENOM" id="CLU_014881_3_0_11"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="7">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="526" mass="54861" checksum="D9293B117724D0B6" modified="2014-06-11" version="1">MTVYVPRDSSARSVGADDVADALTGLGVDVVRNGSRGMFWLEPFVEVDTPSGRVGYGPVAAADVPGLLAAGMPDGGAHPLRVGLVDDVPWLARQNRITFARMGVVDPLSPDDYEAHGGLAGLRRALSLSPAEVVEEVTESGLRGRGGAGFPAGIKWKTVLGCDGPLKFVCANADEGDSGTFADRMMLEGDPFALIEGMTIAAHAVGATEGYVYIRSEYPDAVATFRTAIDLASSRGWLGTGILGSSLDFQLHVRVGAGAYICGEETSMLESLEGKRGMVRAKPPIPAIEGLFGRPTVVNNVLTLATVPAILASGAAAYRKLGMERSRGTQVFQLGGNVARGGIVETAFGLTLGELVHDYGGGSRSGRPVRAVQVGGPLGAYVPTSQFGLPLEYESFAAAGAMLGHGGVVVFDDTVDMASQARFAFEFCAEESCGKCTPCRVGAVRGVEVIDRIRTGEDREKNLVLLEDLCVLMTDGSLCAMGGLTPMPVRSALNHFAEDFEPPAPGPVEPVPENAAKAGSRTEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3I0</accession>
    <name>A0A010Z3I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
            <ecNumber evidence="2">2.1.1.17</ecNumber>
            <ecNumber evidence="2">2.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="2"/>
    <dbReference type="EC" id="2.1.1.71" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851478.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3043"/>
    <dbReference type="HOGENOM" id="CLU_037990_7_3_11"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080101">
        <property type="term" value="F:phosphatidyl-N-dimethylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="23486" checksum="E0E62DD4EFCB96FE" modified="2014-06-11" version="1">MNRDERWRQFWDKQAGSYDRQMGFWDRRFFADTRPWICSQASGATLEVAIGTGLNLPHYPTGARLTGVEWSPQMLEQARRRAVSLGRRIDLTIGDAQALRFADDEFDTVVCTFSLCAIPDERRAVDEMVRVLRPGGLLLLADHVEARPWLGRLLQRTLEVVTVPSAGEHWRRRPIRHVEALGLPIERHERFAAGVVERFAARKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z639</accession>
    <name>A0A010Z639_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852682.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3925"/>
    <dbReference type="HOGENOM" id="CLU_003827_2_0_11"/>
    <dbReference type="OrthoDB" id="1345710at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="511" mass="53491" checksum="A16274A6CE060817" modified="2014-06-11" version="1">MRTLGLGAATGVVAAGAALGSAEPVAALIGRGTSPVVAVGLAVIDLVPRPVKDFGIRTFGANDKVALLTGVFVLLALFAMACGVVSLRRRWLGAAGVALFGAVGVLAAVTRPGAGPLAWLPSLAGAAVGVTVLVFLAPRGAAVGSAPPASGSAGPSRRRFLRLSGVVVVGAAGLGAAGRFLENLRDVARERLSIALPAATDPAPPLPVGVDPGLPDLTPFLTPEKDFYRVDTALAVPQLSTDGYRLRIHGRVRTPLTLTYADLLDRDLVERVITLSCVSNEVGGVLAGTARWLGVPLKSLLDEVQPEAGADQIVSRSVDGWTCGTPTSVVRDGRDALIVVGMNGKPLPIERGYPVRMLVPGLYGYVSATKWLVDLELTSFAAFDPYWVQRGWKAKAPIKTFSRIDTPRPLSGSKAGPVTVAGVAWAQHRGIERVEVRVDGGTWNTATLAPVPSADTWRMWRWEWDATTAAPGPHTLEVRATDRTGATQPERRAKPFPDGATGWHSVVVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z677</accession>
    <name>A0A010Z677_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078789_0_0_11"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="89"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="208" mass="22607" checksum="12D2EB7405AB4B94" modified="2014-06-11" version="1">MIRVLRNWWAEASLAAAFVALTAALVWWPPLLDLDRAVRDWCDAHRPQWLHTVLVGFDLLGQRALVLPLVLVVAGVLAVRRRAVGPLVLAVVAAGVNSVVVEVLKRWTSRGAPHHGSIEMFSGDPAVEYPSGHVSNGLVYYAVLAVLLSGVLPPLARQLLRWVPGVLVFVGTTGLAWHWLTDSVGGYLLGLLQVLLLLRLGKFSTRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMS2</accession>
    <name>A0A010ZMS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848743.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1015"/>
    <dbReference type="HOGENOM" id="CLU_050180_0_1_11"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="74"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="35769" checksum="024ABB158B272D52" modified="2014-06-11" version="1">MDGRVLHAKQVAIGAAFGGGGLGLLSAAFYGLLLGQANLARRAIQPLEAGPPPADGRYTPPTGASSGPAVQLALLGDSSMVGYGVDDVAQTPGALFGTALARLADRPVDVVSAAVVGARSVDLAVQVDYVLAQPQRPQLALIFIGGNDVTHKTRPSIAVGQLKRAVRRLVDSGVDVVVGTCPDLGTIRPIPQPLRYIVRRWSRDLAAAQTVATVEAGGRTVSLGDLLGAEFAANPVEMFSPDRFHPSAAGYGRAVDAMLPSAAAALGIGSAATDEPRPERGEGVRSLVDAAVAAAEAAGTEVAPAEVAGRERGPWGRWVELRHRIRLFGGTPTVGTAPEAPPADAALGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN18</accession>
    <name>A0A010ZN18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848868.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1125"/>
    <dbReference type="HOGENOM" id="CLU_1560940_0_0_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="32"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="18364" checksum="A213D12AF34892EC" modified="2014-06-11" version="1">MTDLAAIEKQRELLRDTYLQPDGVRPASSARGLHHTALISSSVERTIWFYQDLLEFPLTELIENRDYPGSSHFFFDIGNGNLLAFFDFPGLDVGPYAEVLGGLHHVAISVEPEKWEYLVRKLSDSGVEHTVHSEVSVYFRDPDGARVELIADPLGEMYGQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNB9</accession>
    <name>A0A010ZNB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Propanediol dehydratase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848983.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1226"/>
    <dbReference type="HOGENOM" id="CLU_120853_1_0_11"/>
    <dbReference type="OrthoDB" id="1735206at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003207">
        <property type="entry name" value="Ppandiol/glycerol_DeHydtase_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036091">
        <property type="entry name" value="Prodiol/glycerol_DeHase__sf_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02287">
        <property type="entry name" value="Dehydratase_SU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47148">
        <property type="entry name" value="SSF47148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="13039" checksum="BB420ADA1BDE971E" modified="2014-06-11" version="1">MKAFSGRPLESVTLEAVRAGEVGPDDLRIHPETLEHQAQVAQAHGNPQLAANFRRAAELTAIDDADVMRVYEALRPRRSTFVELEEIAEWLSARGATMNAALVREAAQVYRRRGLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP85</accession>
    <name>A0A010ZP85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725635.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.55"/>
    <dbReference type="HOGENOM" id="CLU_660458_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="270"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="490" mass="52836" checksum="770A66101C510E98" modified="2014-06-11" version="1">MQPSLDAAEAFRSITRILDDVSGRPVELPALRRVLDALVELVGGVGAAFLLNEPGALRVVAAGESVSWMSGLRLPLSGSSFSRLFGGPHRTIEFGPGDATPLIREDLREHHCDWILMTRVVRRFGPLGALAVGLESPRGGQLETERAVLECLAAGIGALAAMRPDRLPEPIGTVAAAVPEGLAVVDVSGLVQAWNPAAEEVTGRSSREMLNECLPFPIPAPGEVRQHRLPNDRWIEARCAALDAARRVVTFYDVSEARRQEEAQNLFLATASHELRTPLTIVRGYADTLVNRWDQLDDAGRRGAAEVIGARSRQLAELVDRLLSGDRAGGTPQPFDLRAALAVVLESAPESEDGHRLHVRIPATLPTAVGEADTIPTIVTELLTNAYKYSPGGGDVEITAGADGASVWFRVADRGIGVPAEQTESVFTRFWQVDRGDQRRFGGVGLGLYIIRRLLDRQGGWVSLRPRDDGGSVVEVRFRRAGHQTVGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPG6</accession>
    <name>A0A010ZPG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.137"/>
    <dbReference type="HOGENOM" id="CLU_026001_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="607" mass="65901" checksum="7BB73D7F9A41E791" modified="2014-06-11" version="1">MSERPGRSTFEPESRRWGRRGLVTGALAAAGLAVAACSKDDETPPKPSTKTGGGSPVDAADSAGPAQSSTAGGTAPTGGDTATKSLDRSTGGNSRRAAGRQARTVRTYSDRDQSYAAAGKPRRRPSVPAKLYSGPAAAATATKVGSPLVFTADPVLHLVRRTTFGATPELVAEVRETGIDAWLSRQLQPDSVPESNDVRTAEGVFTTYDRTIKQLRADKERLGDKRPFADQENVRLTIARQIWSRRQLFEVIVDFWNDLFHVANPFDGSELVRASFDTDVIRKHALGTYKDMFLAGNRHPALLRYLNQDQSRKDRVNENLGRENMELYTVGVDGGYTEVDVRQAALLQTGRLIKDDEFFYDPNAHHVGAITVMGFSHPNDDAEGGLEAGDEYLSYLALHPSTAEHIARQLCLHFVSDTPPDSLVARLKKSYLDNRSAIVPVLMTLFSSSEFWGSVGAKVRRPMEYVVATHRALGVRPGDDLRDGLASVHNRMRELGQYPMGQPSPNGYPRVFSAWASAGTMIEEWNEARALVAGGRKGFTFVKPAELLDDAPATAGEFVDALSVRLVGQKLPAKDRAAVLSIGGADGDVPVIELARAILASPYHSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ33</accession>
    <name>A0A010ZQ33_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">CryarDRAFT_0335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847867.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.320"/>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_11"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="779" mass="78517" checksum="3C69562FB247E5B0" modified="2014-06-11" version="1">MEGLNSAIDGGGVNISGDNITYVVIAAAIALLALGVAAALVRAVLAAGQGTAKMQEIAAAVQEGASAYLARQFKTLGIFVVVAVVLLFVLPVPGDDIGVRIGRSVFFVVGALFSAFIGYIGMWLATRANVRVAAAAREKDGAPTAVRIAFRTGGVVGFFTVGLGLLGASVVVLIYKGDAPTVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVASLILGRVAFGEEGLVFPLIVPAIGVVTAIIGVFITRLRASDKNGMTAINRAFFISALISAVLCSIAAFLYLPSSFDGFTGVSESIAAHDGDPRLIAVVAVLIGIVLAAAIQLLTGYFTAVGSRPVRDIGKTALTGPATVVLSGITVGLESAVYTALVISAGVFGAYLLGGGVTVISLFAVALAGTGLLTTVGVIVAMDTFGPISDNAQGIAEMSGDIDEAGARILTDLDAVGNTTKAITKGIAIATAVLAATALFGSYTDAVRTAATEAGQRITGEYAGVLDVANPKNLVGLIIGASVVFLFSGLAINAVTRAAGAIVFEVRRQFREIPGIMEGTGKPEYGKVVDICTKDSLRELATPGLLAVLAPVAVGFGLGVGPLGAYLAGAIATGTLMAVFLANSGGAWDNAKKMVEDGAFGGKGSAAHDATVIGDTVGDPFKDTAGPAINPLIKVMNLVSLIVAPAVVTLSVGADENVGVRVAIALVATAVIVGAVIVSRRRPISIAEDEEEPAKVPTQPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQF4</accession>
    <name>A0A010ZQF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="27050" checksum="7AEC8CCFB65AC7F8" modified="2014-06-11" version="1">MIAVTGAAGKTGRAVLAALAARGVETRALVRPGSVAEATETVPVDLADARQVASALTGASAVYVIAPNVHPAEPELVANVLAAGVPRVVYHSVLHPAIEAMPHHWAKARSEELLYASGADWTVLQPCAYAQNFVRGDALRVPYSLDAKFAFVDLLDVGFVAARVLVEPGHSYATYQLAGPELVSVAAVAELLGVRAEQVDVNDWYLDTGLRGYARDALGAMFTYYDAYGLVGNSRVLRMLLGREPTRVAEVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQJ5</accession>
    <name>A0A010ZQJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and a GGDEF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850078.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2009"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_11"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13864" checksum="3D67ABB65A513D46" modified="2014-06-11" version="1">MVIDDSRAMRLILRRIVTGLNFDVVEAGNGREAMDRLEELEAVPELALIDWNMPEMNGLEFVTAVRADKKYRGMTLMMVTTESEHGQIVRALAAGAHEYVIKPFTPDAIVDKLVMLGLIPDGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQM8</accession>
    <name>A0A010ZQM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848238.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413727_0_0_11"/>
    <dbReference type="OrthoDB" id="820149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="663" mass="70694" checksum="A3A03E198B9C3F75" modified="2014-06-11" version="1">MKRAAPVLAIPVAWLLPWATHALRVDAVLPVLLVLGIASLLRVGTTLLDRVALALFLFLGLVSAAGLVFSVWPWGLDPVAVARAGFLGLIAAALISRRVPRLPLKITWSDALLVLGGVAPAVFLWSSFWGKPAAERLAMMIGAEDLARHFTIFDTIRSVGGYLPFHRDEVARQVIPGVVDYPQSSHLVSALMDNFARSSTDLGNGLVAFDHYLAWNLVGYGILAFTLVWALRWVAGPALRGWRLVAAVAVVVGCTGGGYLVSLFDRGYPSEALGLALLAVVFALSARPVRGAREQMLLLAAGLVGVSFTYYFFLPVAGAAVLVWALVYARSRTRGPWRLGPLAIAVPAVPLVLVWPVLSLRSGVSPTQALIPDVGIPEVDQRLVVALVALVLLGSLTRTGRRIPIWRSVSAQVVLSGLMVFAIGGYQLANTGGVSYYFEKAIHGVLIACFVGFGAIALLLPRDPFSWGAGQGGAAAALRRLAAFALPAGASVVVAAFAYGLLMPDRMLMTRTSERGGVTEPDAGTSRGRAFHGDKLWRPNDGKSAVNAYRRFPNGDDGRVTLVISAYRLYTPSLYLAGFRRQGGEAARPVSGINGSKEMATLEHVAEVSPRPVRFVVSRDDLVTGLRALAKRRPDLKIEVVVLPAAQIPTPPALPPPPGGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQN7</accession>
    <name>A0A010ZQN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose mutarotase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848255.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.555"/>
    <dbReference type="HOGENOM" id="CLU_052486_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="33050" checksum="B15467BDD0969C7E" modified="2014-06-11" version="1">MTARWNTPSGHQWTIEAGTQRVTLVEVGGGLREYTVNGRDVLASYPADAMASKGVGQILAPWPNRIRDGKYTFDGQEHKLGWDETDKRTAIHGLVRWELWDRLDHTPTAVTLARTVQPRPGYPFALVLRVTYSLGKDGLKVEHQAINVGPTAAPFGLGVHPFLTLGGDALDTATLTLPAGKRILVDDRLLPTGELADVDGTEWDYREGRKIGSASLDTPFVVTERGSDGIAVSELVDADGRGGQLWQDSSFGWVQAYNGIGPGGEANRAVAVEPMTCPPDAFNSGEGLITLQPGERWTGAWGVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQS4</accession>
    <name>A0A010ZQS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2088"/>
    <dbReference type="HOGENOM" id="CLU_899307_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="115"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="32202" checksum="759103F9432F854C" modified="2014-06-11" version="1">MTGRKDNAPGNRRVQRTVADALPGRSLTLLVALIATGVIAIGTTAIGGTAAHAAEVATVPVAEESPASDAGTGSGNVRDTTKDQPSDAVVTSESPEPLPPNPDLATARSIPLTEADKQLLIKVRQAGLWEIPSGEQAQQKAESPIVKAVGRQLAADHRKLDDSVRKLAADLDVVLPSTPSELQQGWMAELSKASGADYDRLFADRLRAAHGTVFNIIAQVRTGTRNPIIRAYAQTANTVVMRHMTLLESTGLVAFDDLPAPVLSQASSTSGSGGLSESSPGMRTMAIVAMLAAAALIGLVSVRRIRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQZ0</accession>
    <name>A0A010ZQZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850262.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2155"/>
    <dbReference type="HOGENOM" id="CLU_069356_1_2_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="21630" checksum="66F9770FAD2062C5" modified="2014-06-11" version="1">MPEQPSTPRGAATYQRILDVATQEFARHGIAGARVERIVAAAHTNKAQLYAYFGNKDELFDAIFFGSLERIVNVVPIGAADLADWAVRLYDEYLRRPDLIRLATWARLERRPTGHLVENHDAYEDVKLRAIAEAQAAGRVRPGDPFDVMAMVIAMSMAWSPVSNVYAATGDEPAAAHEKRRALLRECVQRAVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRF3</accession>
    <name>A0A010ZRF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848529.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.790"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="35718" checksum="ECC0949305171EED" modified="2014-06-11" version="1">MTRRLAEVAQKVGVSEATVSRVLNGRPGVSDATREAVLTALDVLGYERPTQLRGERGRLVGLVLPELQNPIFPAFAEVVGDALAQKGFTPVLCTRTAGGVSEAEYVDLLLEQHVSGVMFASGLFAQADAEHAHYERLAARRLPVVLVNAGIERLRFPRVSCDDGVAVEQALGHLRSLGHERIGLLLGPADHVPSQRKLAEFRTIAAELGVPTPPDFVENAMFSLEGGQAAATKLIERGVTGVICASDVLALGAVRAARRRRLSVPADLSVVGFDDSAFMNCTDPPLTTVRQPIEAMGRAAVELLANQIRGVSVAPDELLFEPELVVRASTARVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRS7</accession>
    <name>A0A010ZRS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.963"/>
    <dbReference type="HOGENOM" id="CLU_047691_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="76"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26158" checksum="964937A9CFE64463" modified="2014-06-11" version="1">MTDSARIVRLAPPAPETEPLPELEADEVEGLTELIDADETVAPRPAGIRRANLTPDEAAMLVGAAAGGDRSAWDALVDAYGGLIWAVARNHRLSPGDAGDVSQTTWLRLVENIDRLSDPARVGAWLATTARRECLRLLGRSKRTVLSGEELDPGTDRLRLAAPEADAALLAAERDAEMRSAFGRLTPRCRELLQMLLLDPAPSYEEISAALDIPVGSIGPTRGRCLEKLRGIVEGTGINPAAAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRT6</accession>
    <name>A0A010ZRT6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">CryarDRAFT_2465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850655.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2428"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_11"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG81354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="30869" checksum="8917CBA60F9F4C7E" modified="2014-06-11" version="1">MLRIAVPNKGSLSERSTQMLVEAGYSQRRDPKELVLTDTENEVEFFYLRPRDIAVYVGSGDLDLGVTGRDLLLDSGADAVEMLALGFGRSTFRFAARPGTVESVTDLAGRRIATSYPGLVRAHLAEHGITAEVIRLDGAVETAIRLGVADVIADVVETGATLRQQGLEIVAEPILRSEAVVIRGKGRAETGADHRIDQLTRRLNGVLVARRYVMLAYDVELARLDDAVSLTPGIEGPTISPLHKDGWVAVQAMVPRDETNRIMDTLYDLGARAIIVTSIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS15</accession>
    <name>A0A010ZS15_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2531"/>
    <dbReference type="HOGENOM" id="CLU_665185_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="295"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="413" mass="38490" checksum="29048B81F33F6FBA" modified="2014-06-11" version="1">MSPEDARLAPLVEACRETGAIVLAGAPVGFPAGLPAGSPVGSPAGSPDGFSVGSPVGSPDGFSVGGSAAVFSCCGAGVPALGGGGARSLAADGAGVPGLGAGEVTRSSAGEVSAPEGGVPSLGEGGALRLGAGEVCVPGGDEVAGPGAGEMPVREIPMPGVSEMPVPGVSGVCVPGGDGVAGPGAGERPMPGASEMPVREVPVPGVSGVPVPGVSGVYVPGVRGAGGDGAGGPGAGGPGAGGPGAGGPGAGVEFVAGAGEPGAGGVTRSIGMLVVDGTGARVGYRKQYLGGGEGAVFTAGTGPAVIEVDGWRLGLAICKDTGVEQHAADTAALGIDVYVAGVLETAEDFDVPAERAARIARAHGVPVAIASFAGSSGEGFARAAGGSGVWAADGSLLARAGTRTGEIVQVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSC5</accession>
    <name>A0A010ZSC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1167"/>
    <dbReference type="HOGENOM" id="CLU_018489_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="360"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="563" mass="60413" checksum="FEF12CA475E41744" modified="2014-06-11" version="1">MVSGTTFGYLWVTARCGGAPVELAIAASPDQAPVVEKLAAKWQEDAPEIDGRCAEVSVRAAQSAEVAQSLTPNWKADSDVPRVDVWMPDSSIWIKSAAARPDVKPMVSNTPTVVAKSPVVMALPKPMAEAQGWPDKVISWAELAKTRVAGTTWARFKHPEWQQIKIGIGDPRASFPALGTLLSVADADGDNSVTEAELGNALVLARASTVEAATSDTFLARMRQVTNAQAGLVNAGPFPATEAQVAAYDNAKPKVPLVAINPEEGTVFADYQYQVLKADWVDSVRQKVAAEFLQFLQSEDSKRAYGAAGFRDPQLSTQYAVGLDTDLGMGSLPSAARDIPDIKSITQTVGYWTALQRKANLLAVIDSSGSMADPAPDGNGTRMQVVQQACLRAVALLNPQSNIGAWRFSTELNGDKDYQDMVPIGPAGGQLPDGTPRKDALQEFIYNRLVPEGATGLYDTMLAAYKNLQNHWQADNRLNLLVMMTDGKNEDPDGITQQQLIQQLRATANPDKPIQVLIIGYGPDADLNELTTITKAVGGQAFPARTGADIEKVFLATLIGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSF2</accession>
    <name>A0A010ZSF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851023.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364294_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015757470" evidence="2">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21203" checksum="F3ED2C6625E64063" modified="2014-06-11" version="1">MARLSAGKWLGVVAVSTAVSAAAGYLVSAAQESPGLTAGAVAIGVVLGLGFGVVVTGVGAGLVWFLRRRGTGLTSPVADLGPRGVPARGAETGVTLASPLRDLSRTDSRTVRDALKRTEPPEDPELHAIARYEARRLTKYLTFAVWFYPVVLVLQGVQVVSGDRLWQRLVGGYCVVFFGALLVVSIVQLRRARRYLTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT26</accession>
    <name>A0A010ZT26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849209.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1409"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26277" checksum="29B3C641D57661CB" modified="2014-06-11" version="1">MTDLSGITAVVTGGNSGIGRAMAIGMARAGADVALWARDTARSASVVGELRALGVRALAVGCDVTDENAVSDAMERTVAELGPLGCLVANAGVTDGAPITEMSLDRWHRVLRTNLDGAFLSTREAARRFVAQGSGGSLVIVSSTVSRYGGAGLAAYATSKTGLLGLGRTLAVELARHRVRCNMLLPGWTRTPMTEPLRADERFLAATTSRTPVRRWGDDADFHDVAAFLADPALVFHTGNEVVVDGGYTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT81</accession>
    <name>A0A010ZT81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">CryarDRAFT_1496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849292.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1468"/>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_11"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="614" mass="67858" checksum="F4A456CB20EEF119" modified="2014-06-11" version="1">MPPTPRPGSTDPSLIRNFCIIAHIDHGKSTLADRMLQMTGVVNERQMRAQYLDRMDIERERGITIKSQAVRLPWELDGTTHILNMIDTPGHVDFTYEVSRSLAACEGAVLLVDAAQGIEAQTLANLYLALENDLHVIPVLNKIDLPAAQPEKYAEELAKLIGCEPEDCLKVSGKTGVGVQPLLDEIVRQFPAPKGDANAPARAMIFDSVYDTYRGVVTYVRVIDGQLNSRERIKMMSTAATHELLELGVISPEPVPSDALGVGEVGYLITGVKDVRQSKVGDTVTNNAKPAQQSLPGYAEAKPMVFSGLYPIDGSDYPILREALDKLQLNDAALAYEPETSAALGFGFRVGFLGLLHLEIIRERLEREFGLDLIATAPNVVYRVIMDDTTEHIVTNPSEFPHGKIESVFEPVVRATVLAPSEYIGAIMELCQSRRGTLQGMDYLSEDRVELRYSLPLAEIIFDFFDQLKSRTKGYASLDYETTGEQAADLVKVDILLQGEQVDAFSAIVHKDKAYNYGTTMAQKLRELIPRQQFEVPIQAAIGARVIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFIAALSTGDAKESGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTU4</accession>
    <name>A0A010ZTU4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851710.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3223"/>
    <dbReference type="HOGENOM" id="CLU_054340_0_0_11"/>
    <dbReference type="OrthoDB" id="596492at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28388" checksum="389536D25D9035C0" modified="2014-06-11" version="1">MTTSSTLGTPGVRLTPRSEAELVDGLRRGIDRRFGPCVEHFVAPPVIDRRVVELVGYPESFPQLLGSVYGAPQGGPVAATDLVLTAAACHHLYPVFADRALASPVVASVEAACYRGEATSETGRLRSFRMYEVVCLGPAGAVEEWRDRTLTGAAGWLRELGLGINVVAANDPFFGRTGVLLASTQRSQGLKSEFTAEVDDGLVQAIASVNYHKEHFGEVFGIADADAGTAHSSCLAFGLDRVVLALRRRHGDDVSGWPPEVRSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU08</accession>
    <name>A0A010ZU08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar diacid utilization regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851802.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3286"/>
    <dbReference type="HOGENOM" id="CLU_485567_0_0_11"/>
    <dbReference type="OrthoDB" id="1439158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="337"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="503"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="569" mass="61615" checksum="0B92E1AAF4F73125" modified="2014-06-11" version="1">MPPDTPNTKVGDSEHPDNWWREQLSNLYGLFVVSMMMFDGRDPDDILRLATTSLPALCECIADTVYLRVDRALIPAHGDTPDPDLVTALLSLDGQSGPVPTKDGRWRWAMALGSPAELLGYLVVCSRSEPSSEEFFLIKALAQQTSGALASARLHQREREHATALLTLNTELQALNGRLSESVARLEAQTRVHERLGEVSASGAGEAGIALALHELTGLSAAVEDRFGNLLAWAGPDRPDPYTKVVPHRREALLRQAAAVPHPIRVQTRVISLAKPRQEVLGVIALVDPRHTAGAHEVFALEYATTVLALELSHQRSLAQAELRLRRDLVDDLIAGTDEHSAYARADALGHDLRGTHQVVVVKWSRTQTDDAVAAAAAAAAAALQLPSLISRRAGSVVLLAPGPLVGVSLHRALADKLGGTAGAVGVGGRCRGPTDVPRSYAEAVRAADVRRGSRSPDGTTSYDQLGLYRILDTGAGTGEVQAFVQEWLGELLTYDQRKSADLVHTLSQYLECGGNYDETAAALLIHRSTLRYRLGRIRNICGHDLTDVDDRLNLHVATRAWQVLRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUD0</accession>
    <name>A0A010ZUD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570409.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3393"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1065" mass="113578" checksum="05B1A7B1F5CC6FDB" modified="2014-06-11" version="1">MAPTVGDLRGDAESPAPPRESLRLQLLGPLRIWRGDVELSAGPRQQAYLLALLLAQPGRTLGVGELIDMLWEDDAPVTALNVIQKHVGALRRLFEPTLPARGSGSYLRRDGDGYAFVADGVRLDVVTFHALVEAAETAVAEQRPEDALRHYVAATALWHGPAGDGFAHPPAAMPVFSALDDEFLAACVTAAEIAITLGTPESVLPCLRVAAAIGPLNEPVHASLVSALGAAGHRVQALAAFQAVRTRLTGELGVEPGPRLRAAHLRTLEQPVPRTPTRRAPSPEPEAGQPAPPPEMVGRAEELSALRRAADAVVDHGSVVALVEGEPGIGKTRLLEHAAAEARGRGLRVVWGHSLEGSGAPPLWPWARVVDGLLGGPTTTAGERRLTGELGPLLNPNASDEPARPPRGARFRLFEQVVAVVAHASAERPLLIVLDDLHWADDTSLQLFAHLAGVLPRGVLLVGALRDRAPVPAPGEELARMLAAVSRLPDHRRIPLGPLSTAEVAELFRRETGQNPTAGIVRSLSSRTAGNPFFVRELSLLLAEDGVVTEAATERAGVPSTVRDVVRDRMSGLSDQTRTLLEIAAFVGRDVDLRVLAAASGVDTLQCLDRLEPVRGLGLLEPKPGDPFTARFAHDLIRDSLVEAVPAHLARRLHLRIADAVAPGEPGGEFAAERLAHHLLAAGSLADPARTTGALLRAGRNATAAGALEAAEQQLRSAVRVARAADLTQLELVALTQLNAAHGMRSGYVSADLDLLERAETLAWTLGREVEAAGFLLTRWTAHLQVLDFTHATPLARRLLDRGDASPEPSVRAIGWFAWGIHQWHLGEAGEGYRFLSRCAHGLPRGDAGPAGDPLRLAVQVPVWLAQVTAAHGDVEGARELFDAVEEEMGDDPYVVAVWSAFSALTAVQANDPAWALRAAERGLVTDSDLVFPTLRTHQRLARHWAHAATGRDPARAAAEAEELILTTLADPPLRSVAGWYGALTEMWLAAGDLARAAAALDRAEHFLRIGGQRDAEGHLLLVRARLLRAEGEPAAVVRAATERARALCVAREAHLFARRADELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUF5</accession>
    <name>A0A010ZUF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849918.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1885"/>
    <dbReference type="HOGENOM" id="CLU_037937_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40279" checksum="3A2B679BF28DC400" modified="2014-06-11" version="1">MTGTDHPTSLGALLRHHRTRAGLTQRELAHRVGYSRSTIANAETGDVRSADFYRRCDDVLAAAGTITAARAAIGTHPGPQAGAHSASQAGTHPDPRVPALEYRLAGVPPQETIEHLRRQWHLLVRTDNLFGPRAALPDVRAALRVLAALEAGGPARTARLCLSARYAITASWLYQDTGLPADATTWAGRAVERAHESGDRASLAWALHRQSRLAERDDPHRALALARAALRQGTDAQRPLAAALHVQCARVVALRGDRAGCDALLTRATLLADARESAGDGRTGYGGHCTRAWVLAARGECALLLHAPADAVRPLRTALTLLAPAYRRDRGLVLGRLVRARTLLGDAAGAQRAATECRAIGEATGSASVLALADAAGVSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUS2</accession>
    <name>A0A010ZUS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flhA</name>
        <name evidence="9" type="ORF">CryarDRAFT_2052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569986.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2017"/>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_11"/>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="693" mass="72972" checksum="B9C84041A4BFDE6D" modified="2014-06-11" version="1">MSSYLRSAVNFKAIGPFAVPVGIVSIIVMMVVPLPTFLLDILLALNITLSLVIVLVSLYVTRPLDFSIFPALLLVATLFRLALNISATRLVLLDGFAGHVIEAFGHFVVGGSLIIGLVMFLILVVIQFLVITKGAERVAEVGARFTLDAMPGKQMAIDADLNAGLIDEGEARRRREDVAAEADFYGSMDGASKFVKGDAIAAIVITAINLIGGMTVGILQKGMAPMEAVNTYSLLSIGDGLVSQIPALLLSVSTGLIVTRSATSGDMGTSVVGQLGAQKRAVQIAGAAALALCLIPGLPKLPFLLLGAGTLFLASRLPSADQRKEDEAAEQAATATPTGPSPDSPEALLGEMRVDPLELALAPDLVDLVDTSGGDLLDRVRALRRKVALELGIIMPPVRTHDDLDLPLSSYGIRISGVEVARGQAPPGTALAIGDGLEALPGRAGHEPVFGLEGKWIPAELRHQAEIMGATVVDRASVVITHLAEVVRQNASRLLGREDVRNLTEVVKRSHPVVIEELTPALLSLGEIQRVLQHLLDEGVPIRDLVRIFEGLSLAAKAGSTPDGLLEAARSSLGPAIANHYVVEGRLPVMTLDPQIEQALLESLRPGEGGIQLGVDTARAEALVTEAHRLFDTAEQRGTTAVLVCSPVLRLPLQRLVRLATPRLPVLSYTEISGVSAQIETVGVVGGVYPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUU0</accession>
    <name>A0A010ZUU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852267.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3615"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="158"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="30493" checksum="A1CB73C6B1B692B5" modified="2014-06-11" version="1">MTYAAGAPVTVGVDGSPASLDAVAWAADDAGRRGRSMRLVYVNSWPAYTYAMWPAWGPPESRDGQEAGRLIVTDAARHAAVTAPATRVTTEVVDGGPASVLLDRAEHSALLVVGRRGTGGFPQLVVGSVATQVAIYAGCPVAIVPEHPAPAAGDGPGVVLGVDGSDQCQAAIEYAFTEASLRGRKLTAVRSWYWPSDDPAIVEPAPLPAHHLLEQQRLVSEGLAGWAEKYPDVEVRTVIAHHRPARALLDAAAGAEMLVVGARGSGGFRALLLGSVGETVARHAHCPVVIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV16</accession>
    <name>A0A010ZV16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852410.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3696"/>
    <dbReference type="HOGENOM" id="CLU_914757_0_0_11"/>
    <dbReference type="OrthoDB" id="648986at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="32056" checksum="D560DABC0324D0E9" modified="2014-06-11" version="1">MSTLATPPDVEFSDLGTGDPDETTPGGSSTWYFRGHNFVLAHTTLVAGDELARADQPDEYVVILPYEECGIEVRASQEVASVSGRAVVMVPPGRSAIVGVEDCTVVRLFSCRSADLLDKARNRSSYAEPHPNVRPFEPWPDPPEGYRILPYRLADLAVTPDAVRPGQIVRCSTFMVNFLAPRVGPRDPDSLSPHDHDDFEQCSLAVEGEYVHHLRTPWSKRRREWREDRHLRCGSPSVAVIPPPMIHTSEAVGPETNQLIDIFCPPRLDFSRTPGRVLNEDAYPLPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV37</accession>
    <name>A0A010ZV37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850226.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2133"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OrthoDB" id="1367386at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="30581" checksum="7537FC6905E5680B" modified="2014-06-11" version="1">MAQTNLPGGTYPVADLTLTRFGYGAMQLAGPHVFGPPKDRDAAIAVLRTAVELGITHIDTADFYGPHVTNEIIREALAPYPADLHIVTKVGARRDEKGGWPHARTPAELVEQVHENLRRLGLEALDVVNLRVGGFDTPEPGSIAEQFGALADLREQGLIRHLGLSTVDAEQLAEAQAIAPVVCVQNFYNIANRRDDAMLADTARQGIAYVPYFPLGGLNPLQSDALHGVAKRLDATPLAVALAWLLQRSPNLLLIPGTSSVAHLRENVAGAALSLPADALAELDAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV47</accession>
    <name>A0A010ZV47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850241.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2143"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="34885" checksum="D9D325869D6BB836" modified="2014-06-11" version="1">MPQQRKRATIRHVAEATGLSTAAVSYALRGLQTSEETQRRVRAAAAELGYEADPIARALASGRTGTVGLLCGSLEDLWQQSLAVAMGRELLGQDRYALILDAAGDPAREAILARQLRDQRVDALVVQPIDPSAPDWAALATSLPIVSIGDPLRGVEGGEVLFDNRTGVTLALEHLAGLGHRHIAVLTPNRPSTPDRPAEVHVGVEAARLGLDVRLVTSPHALAGATACAVAVLEAAERPSAVFCFADSIAYGVYAAARQLGLDVPRDVSVMGYDSHPMSALLSPALTTVDWDLDGIVRQAAGLAVEGRTEHRRFVRSPRLWVRESTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV70</accession>
    <name>A0A010ZV70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570016.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2170"/>
    <dbReference type="HOGENOM" id="CLU_049869_0_0_11"/>
    <dbReference type="OrthoDB" id="1397635at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="373" mass="39811" checksum="E793F89D0965C331" modified="2014-06-11" version="1">MSRWRTGTGGGWWRLLTRWPSWAGYAAAGWSLAYGLLGVWWTVGGDGFPFGPVDEDHRTGSILEGSSAGVVAPIMAVVGLAGAVAALLMARGLLAGRWAFGLVAAGWSIAVALTLVIPDYTMLALLAFSPLLLVFAFTGVPGEQEGLGDILYWHRTNLVLLFVCGLLWAATTLAYQRRVRAACPHCGRGRGAADPGPSRETLLRWGHRAVLVAWLAPLPYEVTRVAWYLGFPLGITEDFLRMMQDTPGMLEVGLGCAVASTVGGALTNGLVSRWGEVYPRWIWFKAGRPVPPALAVVPASVVAIVLIPAGLMVVWTPELRGGGWAMSVPALLWIVWGVALGAATIAYHRRRRGTCTHCSSGDDVPGRVVTMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV71</accession>
    <name>A0A010ZV71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852507.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056920_0_0_11"/>
    <dbReference type="OrthoDB" id="1434977at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="34337" checksum="191EA4F0D0070111" modified="2014-06-11" version="1">MNAHRIRRALLLLAATGAAVLALRHLAALGASWSAALHLITGLPWQWPLLLGAVWILGLSAHTWVLTASLPGLTHRRALTLNLAGSAVSNVFPLGGVAGTALNFGMVRGWGHSARDFARFTIVSKAWDVAAKLVLPLLALVALLGLDELEPTRHTAGWLGLAVLSAAVGALVVTALLGRAKPLLAVVRFAERFRRDRTGTWTASVETLLADTSRLVRRRWAGLSGGMSAYLVLQGALFWLCLHAVGVHLPVVVVLTGLVAERVLTLLAVTPGGSGFVEAGTVALLVALGAAATGVLAGVLLYRAFVFAAEIPVGGIATAFWALGRRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVH8</accession>
    <name>A0A010ZVH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="2" type="ORF">CryarDRAFT_2316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2280"/>
    <dbReference type="HOGENOM" id="CLU_063240_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="32635" checksum="66CC2B6C92FE99A2" modified="2014-06-11" version="1">MPGVSIEHGQRPLESGVRTDFRDAMSYGSYLRLDLVLGAQQPLSTHHDELLFIVQHQTSELWLKLMLHELRSARDLLDADQLSWSLKRLARVKRILETMTEQWAVLATMTPSEYGEFRTILGPSSGFQSHQYRAVEFLLGNKNADMLAVFESDPPAWETLHTLLEEPSLYDAFLRLLARRGYPVPKPILDRDVRRAWVEDPELIPVFEGVYDDPAAAWDVYEACEDLVDLEDAFQFWRFRHLKTVQRMIGTQPGTGGSSGVPFLRRALDLTFFPELYSVRARIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVW3</accession>
    <name>A0A010ZVW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NusB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570062.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2421"/>
    <dbReference type="HOGENOM" id="CLU_005316_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="8">
        <location>
            <begin position="293"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="402"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="602" mass="63040" checksum="4C73888FE3CF6290" modified="2014-06-11" version="1">MLVAVSARDAYANLTLPPMLVERRITGRDAAFVTELTYGTLRHRGTLDAILAAGSSRPIDKVDLRVLQALRLGAYQLLFTRVPDHAAVAGTVEVARVALTDGPARFVNAVLRRVAERDLADWLTEVVPPLGDDPIAHLAIRYSHPEWVVRAFADALGEDVARLGEPDSETAKALAADNERPGVDLAARPGRIDPLELATEIQTELTRWTRPATPESPARPATPESPARPAAAAPHLEPTASPEAVTAAAEASVPEVVTAAAEASVPEVATATAEATDSTRTEATDAASQRPPATEEAPSEQPTPEQLAPEQPSAEQAPVEQAPVPEIAAVAEKQAAPSADDPGSLLGRWSPVAVRLPEGAPGNIPAIADGRAHVQDEGSQLCAWTLAAAPLEGPDARWLDLCAGPGGKAGLLAAIGVDRGAHLTAVEVIEHRAVLVQQAVAGLPATVLTADGRDVGTHPDLPEGGFDRVLVDAPCTGLGALRRRPEARWRKEPGDVPALAKLQRELLTAALRAARPGGLVAYVTCSPHLAETRVLVADVCRRTGAEPVDVRGVPEAAAAADLNPTPERVSASRAAALQLWPHRHGTDAMFLSLLRKPVGGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVX2</accession>
    <name>A0A010ZVX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570680.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169120_0_0_11"/>
    <dbReference type="OrthoDB" id="1462308at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="24428" checksum="6AFB344A6A9E2F1F" modified="2014-06-11" version="1">MAVILYSVSTAALFVLLGKVGSLLVAERRSVPWLAIAGVAALFGGLVLQAVWGGAEAALAHDPARSGWWRPFTSVLLQNGGPFGDVFNVVTAAIALALAQWHWGVRRALVLVVAAVLVPDVLDLMVGGGDLGGQARNYVGSSGVVYFLAATPAGALLLAGPGVRRRLLASAVPVAGLALWFLQSNGHGLVSAEGFVVGVLAALVSSRVSGGAGRRAGVRACVARGPRARWRRARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVX6</accession>
    <name>A0A010ZVX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3993"/>
    <dbReference type="HOGENOM" id="CLU_054016_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458095" evidence="2">
        <location>
            <begin position="28"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="420" mass="42490" checksum="75F53E990BFF04E8" modified="2014-06-11" version="1">MLRSYAAIGAVSLLVLAGCSNDGDAKPEKSPSPSAPKSAAPSAAAPRPAFDPPTRFAAQGVALPPEASENKISAGGTNTEPLPVTLHGTTAFIASTASLLAVDTGTGRTLATITPTVGAPGTTPDSPWVGTNPAEAPVLWSDNGRATILATFVVDKPASGTQKAGRAVEVVAVDAKTAKSLWTAQVDVPAGLDGGFAGLAANPVGIDGTTLAVGVSYQSSDGVIAVDLPARKALWSRADFRPDVVSSGVVVGSDTAAVLALDLADGKQRWTAPQLTSVSRLGPTALIASGTGKVAVLDVATGKAREQSTADYTDVRCRFDDKDVTVCARPGWAAGLDATTGKTLWELPDQANTRVAPVVTAVWHGAVYGRTDNGPVVLDARSGKDREVSPGLAPMVVNEYVGIGQPPTGGSGVRSFPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWG4</accession>
    <name>A0A010ZWG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2640"/>
    <dbReference type="HOGENOM" id="CLU_052501_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="457" mass="46173" checksum="92943ED5B663538C" modified="2014-06-11" version="1">MTVSLRRRPLPSERSRDDAGGPGRSGPGAIGAVAGAALLVAGVAGWGAWLTARGVDLHLSGGQPLTGRLDVRLGPALLLPVVVGVGLIAAGPVAAARWRWPVLLAWTWAAGAGWAVSLALVDGVGALGAPLATRWEYLHDVDRVAAVPEFLGTFTDHVLGGSPGFQWVTHVSGHPPGALLVFAGLDRLGLSGPGWAAALCVAAGASAAPAVLVTVRSLAGADVARRVAPFVVLAPTALWIATSADALFCGVTSWGIAALASSAAGRGRAADVRAAAGGLALGAALFLSYGLVLIGVLAVVVVAVRRRVRPLLVGGAVVVAVVASFAALGFWWWDGFLTAADRVREGSAWIDRPTGYFVAVNLAAVAVCVGPAAVGGLTVLARGGLARASALPLTAGALVLAATASGLAKGEVERIFLPFAVWLLVAAGALPAPERRRWLAAQAVVALAVQLGWMLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWX3</accession>
    <name>A0A010ZWX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570165.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2798"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_11"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="211"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="418" mass="44219" checksum="667B151217E7BDD5" modified="2014-06-11" version="1">MRISLVSEHASPLAVLGEVDAGGQNVHVASLAAALAARGHEVTVHTRRDDPALPATVPFAAGVTVHHVDAGPPASVPKDELLPFMTTFGDELAAYWRAERPDVVHAHFWMSGLAALGGARHLDGPAVPVLQTFHALGSVKQRHQGVGDTSPPGRVAAERRIGRSVQRIVATCTDEVRELRAMGVPTDRVRVVPCGVDVALFTPDGPVEARVGRPRLLQVGRLVPRKGADVALRALRSIPDAELVLAGGPPFERLAAEPEAQRLLSLARSLGVADRLVLLGGVERAQMPALFRSADVIVCPPRYEPFGIVPLEAMACARPVVAGAVGGHLDTVADGRTGYLVAPEDPAALARAVTSLLESPSARAEFGAAGRRRAESRYGWDRVAAATEVVYREVLRRPLPPSTVRRLRPAATPTGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWX8</accession>
    <name>A0A010ZWX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative carbamoyl transferase, NodU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851147.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2803"/>
    <dbReference type="HOGENOM" id="CLU_014411_2_1_11"/>
    <dbReference type="OrthoDB" id="509293at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="117"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="373"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="552" mass="59378" checksum="FAED65EF2C89E8FA" modified="2014-06-11" version="1">MRVLGINALFHDPSACLVVDGTVVAAAEEERFSRRKHGKRPVPFSAWELPEQAARWCLAQAGLRPGDIDVVGYAYDPALAEPAESLGLHDPWDHLRQMYAREAPGFLAEALPGLDPAKVRFVQHHVAHAASAAYAAPNSATGSVLVLDGRGEATSHLAGRRVGAELQTLASQRLPHSLGLFYEDLTAHLGFLRSSDEYKVMALASYGSPRMAAELRRRVYSTEDGGFRTTGVDWTEFCPPRGADEAWSSDHADVAASAQLVLEDVLLDLARWLHGQTGDELLTMAGGTALNCVANTRIVREGPFSRVWVQPAAGDAGTALGAAVYLSAMHGAEPSPMAGADLGRGWSEAELEAWLKTAGVPYERPDDVADAVASALAQNQIVAWFQGRAEFGPRALGHRSLLAHPGHSGNLERLNDVKGREQFRPVAPMVLAERAPEIFTGGPFPSPYMLFVHDTKPEWRDRIPAVVHVDGTARIQTVDSAAEPVVAAMLRGFERRTGLPVVVNTSLNTAGRPMVDDPRDALECFGSAPVDLLALGPFVVRRGSLFGRGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXI7</accession>
    <name>A0A010ZXI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Matrixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3021"/>
    <dbReference type="HOGENOM" id="CLU_843902_0_0_11"/>
    <dbReference type="OrthoDB" id="1838203at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458113" evidence="1">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M10" evidence="2">
        <location>
            <begin position="248"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="32851" checksum="90AFE90247846B11" modified="2014-06-11" version="1">MGGMRNLLPLRSALAPTTTVAALAAVAATVAVGAGIATAPAAVSAAPARVTLVAADAGTDVSAVATDGTDVRYQGLTVRIPAAGEGVQAAAQSTSGDLSITVSRSADGSVVVKTDKHEHSVAQAANAITTRADAAKTCTDSAYALAGWKLPSFTWYYNPAGTPAALSGTAAAAVTSGTTALSSACGQRTIGLAANYGGQTSAAVQVGAAGNCIGNDGRNVIGWVAGNGKWLGMTCTYYKTVNGAKTVTGTDTALNTQYKFFTSTANCANAYDLQSVVLHERGHSLGLNHVDQTAHASAVMTPALSACSVGKRTLGLGDYKGLAAMYGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY04</accession>
    <name>A0A010ZY04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376177_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025238">
        <property type="entry name" value="DUF4184"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13803">
        <property type="entry name" value="DUF4184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21267" checksum="0A108D940868AEEB" modified="2014-06-11" version="1">MFWLDPLLALALLVVFHVLLKRPAVALMPPAAAGRAWPPAERFVWRRATAVWWIAVSLMIGAATHLAWDRLDSALGENQSTKVDLASGVLGLAVLLVWLWRWWRITPAQPIPAALRLPARLRTVVRAALVAAPLVLGTIAAVGGVRELVAANQVDHSDLPPHIVPPTFTGIDMAELAVRRFATGRRGATGAGPDDGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY89</accession>
    <name>A0A010ZY89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851796.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3284"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="391" mass="42404" checksum="2476E877934F67D1" modified="2014-06-11" version="1">MRANTWAGRNKVEVRDVPDPRILNKRDAIVRITSTAICGSDLHLVDGYVPTMQDGDVLGHEFMGEVIEVGSGVRADRLRVGDRVVVPFPIACGACSACAAELYSCCENTNPNAGIAEKMFGHPVAGIFGYSHLTGGFAGGQAQYARVPFADVGPLKIESDLSDEQVLFLSDILPTGYMGAEMCDIQPSDVVAVWGAGPVGQFAMDSARVLGAAKVIAIDKEPYRLQMAERAGHIPVNFDEVDVRSRLLELTGGRGPDKCIEAVGLEATHGSAHVAAYDRVKQAVRSETDRPHALRQAIMSCRSGGVVSVIGVYGGLLDKFPAGAWMNRSLTLRTGQCHVQRYMKPLLQRIERGEIDPTRIITHTIPLDEAERGFEMFKNKQDDCEKVVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYW0</accession>
    <name>A0A010ZYW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852168.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632191_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459291" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="77" mass="8556" checksum="6323C5CDF9725E75" modified="2014-06-11" version="1">MRKLFGATLGTLMLGGLLVGGAAPAQAAVEVKGPYTSRSACIQEQSNYARYYRITRQCWNIGPSGNNLWYFNYNPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZP0</accession>
    <name>A0A010ZZP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-mannose binding lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852630.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530109_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459232" evidence="1">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="53"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="175" mass="19282" checksum="1C109D88861F8FD6" modified="2014-06-11" version="1">MSRFSSTGKKPRITRLSAAVVLGALFAVAAWVSPAAAIGLGQCWNTTYKGVSLHVCDADQWLTTGNSWYFGNSRLTMQTDGNLVIYNQRTGRAAWSTGTHGTRANRMDFHGNGRFNPMIVRDDRTGQVYWNSSPNSTCPSDNRTVLALQSDSNFVMYCYQNGTFGRAIWASGTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZX3</accession>
    <name>A0A010ZZX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted/surface protein with fasciclin-like repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570653.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3924"/>
    <dbReference type="HOGENOM" id="CLU_031281_3_1_11"/>
    <dbReference type="OrthoDB" id="1776069at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459235" evidence="1">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="20983" checksum="A50EB02BF0C8B695" modified="2014-06-11" version="1">MIRTRTRLVGATAAALLALSMAACSDDSSSDTATTSGSSMAAAPSASAPASAMPADGPFGAACSAVPASGAGSFSGMSQDPVATAASNNPVLSTLVKAVGAAGLVDTLNSAKNVTVFAPTNDAFAKIPAADLQKVLADKAMLTKILTYHVVGQTVTPEQLGTAGPFKSLQGGEITAAGSGEDFTVNGDAKVVCGNVQTANATVYLIDTVLMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A070</accession>
    <name>A0A011A070_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4053"/>
    <dbReference type="HOGENOM" id="CLU_131430_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="113" mass="12410" checksum="F0212552F4890D78" modified="2014-06-11" version="1">MIEKISLLPEADRLTEFWSQRVLAQGNGTLFKVAKGIGSTTWHRHDDQDETFLLLEGTLTVQLRDGDVELSPGDLLVIPRGVEHCPRADDEVKFLLVGPEITSTAAGGKPAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAS5</accession>
    <name>A0A011AAS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569547.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101739_0_0_11"/>
    <dbReference type="OrthoDB" id="1961509at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="22838" checksum="015A8552615942AF" modified="2014-06-11" version="1">MSAVVDDLRARLRGPHGVRKELLREVEDGLRDAAEAYEQAGLPPAEAARKAADEFGDPAELAPLYQAELDASRGRRAALLIALAYPTLTLAWDALWRYTSVGDGASPDGVATVAGALDTGSYGAAIAAAVAIPLYGRASATTARRLTVGIGFLGWLSLLLILATSIWMAQASGDHAVREFESNVPSMLVVGLTVAASLAIASTATLAVSRWWVPRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABF5</accession>
    <name>A0A011ABF5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">CryarDRAFT_0376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860077.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.361"/>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_11"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="33"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="565" mass="61370" checksum="603B653F0796BCEA" modified="2014-06-11" version="1">MRWSRLYVPTLRQDPADADAVSHRLLLRAGYVRQLMAGHYTLLPLAVRVRTKIVDIIREEMSRIGAQEFSLPAMHPAEIWQKTGRWDVMGDEMFRLRDRKGADIALGMTHEEIFTTLALELRSYRDLPQMWYQFQTKFRDEPRPKSGLIRVREFTMKDAYSFDVDATGLDTAFDAQQAAYVRIFERLGIPAVAVQASSGSMGGSASVEFMCPSTAGEDLIVRCPSCGYAANVEKATSRVEAAADEAGPDAPEQFPTPGVRTIADLADGFGAPADRQIKTLVYLLDDELTLVLMRGDHGLVEQKLLDATGARSVRPAHPEEIREALGALPGSLGAVGVSGPRIVADEALRGRRNMFTGANVDEVHLRGVDVSRDIAVGSWADLREVVAGEPCANCGTGLEVLRTIEVGHIFKLGYKYSEALDLTVLGADGTRVTPIMGSYGIGVERALAAAVETHHDDAGIVWPVSIAPFAVAVVVVGKDEETVAAAERLYAELQAAGVDVILDDRAERPGVKFADVELIGIPFRVTVGSRGVKAGALELTHRATRETESVPLDAVSARVRELVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC06</accession>
    <name>A0A011AC06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569660.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061170_0_0_11"/>
    <dbReference type="OrthoDB" id="1290978at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="31601" checksum="27FEA3C18E60C128" modified="2014-06-11" version="1">MAHVHHFTYGLITLLLAYAVSVLGCLLGLICTARARDTFRVAARVRWLALGSVSIGGTGIWLMHFLAMLGFTVSNTFVFYDPALTALSALMAVGIVAVGIFVVGLGQPSMLKVLVGGIVTGLGVAGMHFTGMAAMRVLDGEVMYDPVLVAASVVIAVVAATVALWFTIVIKSRPALAAASPIMAIAVTGMHYIGMFAATVREVGGRGRVEGVDVTTLLIPSAVIVGTVLIALLYATLSAPAAEERAAEALMTRLLYASEDMQPPPAARPTRATMRTQLRHRVAVRNARTTDSDTPATSVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC10</accession>
    <name>A0A011AC10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848311.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200596_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="61" mass="6843" checksum="BF751089C0BDBE2C" modified="2014-06-11" version="1">MFAILAAITFGLLLFLDLIDQLPIGDLLNWNTLVALGLLFIALHLCGFGTAYPARWRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACW6</accession>
    <name>A0A011ACW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932908_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="32795" checksum="791E3809C5AFC0D2" modified="2014-06-11" version="1">MIASTQAKQATNSAATDEYSVSPYSSTDLDAVHALATAVTGSESYPKFLIAQLADILGPGFLVARDADARVVGYTVATPHAQIEARGVVLALVVDKNHARVERELVGVATTYLRGHGCEEIVFAATTAPEASDDRDDTPAPAGAYRVRQFTPADLDDVHRVELSAFGSDPYPRLFFLQLAEVLGTGFLVAERGTGSERRVVGYLLGVLDMVAPGRGWVMSVAVHALHRGRHVGWQLMEEAERYFREVGRKEVQLTVDPDNEVAVELYQHRYYETVYCHDDLHGMKLSRLVMRLRLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD59</accession>
    <name>A0A011AD59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1027"/>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="35095" checksum="1E0A70992564DEA0" modified="2014-06-11" version="1">MTDAPVQLSPTSDTEAARAALGRLRTEVGKVVIGQDAVLTSMVIALLCQGHVLLEGVPGTAKTLLIRTLAAALSLDSKRVQFTPDLMPGDVTGSLVYDARTAEFEFREGPVFTNLLLADEINRTPPKTQASLLESMEERQVTVEGVPRKLPDPFVVAATQNPLEFEGTYPLPEAQLDRFLLKVDVPLPSREAELKVLTAHHQGFDPRDLSQVQPVATAQDLATARMAARGVQVADQVMGYVVDVCRATRTSPSLAAGASPRGSTALLATAKAWAWLSGRDYVTPDDVKALARPTLRHRIVLRPEAELDGATPDGILDSVLATVPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE44</accession>
    <name>A0A011AE44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2989054_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="57" mass="5911" checksum="B60BAC7EC15FB4B9" modified="2014-06-11" version="1">MIPPLSGETGDAVGRALDLLRIRLLADAATHQQAANHPPTTPRCHTAGTSPRRGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AER4</accession>
    <name>A0A011AER4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine/adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569906.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1583"/>
    <dbReference type="HOGENOM" id="CLU_025810_5_2_11"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="14489" checksum="ED9CABF52A01029E" modified="2014-06-11" version="1">MDPKLLGRAVDLATQNAASGQLPFGALLVRDGEVLATGVNTVLRDLDPAAHAEVEAVRAACRNLGTLDLRGAEIYSSCEPCPMCCRAAQATGIAVIWYAAQATDIPDLGYPVPAPDVFEARHATHAEATAPFARYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF05</accession>
    <name>A0A011AF05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849587.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1702348_0_0_11"/>
    <dbReference type="OrthoDB" id="1992760at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="14331" checksum="97D1DD4306AA1872" modified="2014-06-11" version="1">MSLAFDVNWLAVLIATVACTVLGGLYFGLAVSRPYAAAMGRVGQPAWRPPASALAGQTVATLLVVITSAVLLRTLDVREVGTALLFGLVVGVGYLAAMVLNIAINPNFPHPFRYALLNAPYFLACSLLTSTVIALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG60</accession>
    <name>A0A011AG60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2070"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="28111" checksum="31E307E8ECE00F43" modified="2014-06-11" version="1">MGASAPVDVVRPPVRTRLDGAVAVVMLDSPANRNALSLPVVTGLIDAMDTAARDDEVRVVVLVAEGEVFCAGADLTELTEPGEHHPEIWAEAYLALLRSMVRLPKPIVVRIHGEAVAAGLGLVGASDLVISERSAWYGFTETRIGLAPTLAALLTLPRLAPRAAARAYLTGVTIDAGIAEEIGLVSQVVEDEMLDAAVDFAVASLLAGSPGALAATKELLTRPIRTQLDEQGPAMVKLWSELCEAPEAREGIAALLESRLPHWAVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH94</accession>
    <name>A0A011AH94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="9" type="ORF">CryarDRAFT_2492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2455"/>
    <dbReference type="HOGENOM" id="CLU_024003_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="426" mass="46278" checksum="3386C2E6431F3359" modified="2014-06-11" version="1">MLSVSEFLDELRWRGLIAQTTDEQALSTALDNAPLTVYAGFDPTAASLHAGHLVPLLTLRRFQQAGHRPIVLAGGATGLIGDPSGRSSERVLNTPEKVRELVEKLRPQLAKFVDFEQGAILANNLDWTANISALDFLRDVGKHFPVTQMMARESVSARINSGGLSYTEFSYQLLQANDYLQLYRDQNCRLQIGGNDQWGNITAGLDYIRRVTANEGGHAHALTLPLLTNASGEKFGKSTGGGSVWLDPDLTSPYAWYQFWFNTDDRDVVSRLKTFTFLDRKEIEELEAAVAERPAARLAQRRLAEEMTTLVHGADETAAVTAASGALFGRGELGGLPADTLRAALAEAGLHEVSGELPSVAALFQASGLAASLSEARRTVREGGAYVNNTKVTDGEAPPSREELLHGRWLVLRRGKRTVAGVEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIW2</accession>
    <name>A0A011AIW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862642.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054751_1_0_11"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="27621" checksum="351703624F52E127" modified="2014-06-11" version="1">MSEVVLTGAPYAVTGDADGTVWATVLSPPGLARVRDGEVSYETLPDRPMLLTLAPDGALWYTAGDALGRRDVSGEHTVTALPEGSAPYGIAAAPDGTIWFTAPGRNQLGRLGDELVLVDLPVPDARAAMLTVGPDGAVWAALNGAGALVRVHDGSVDVVALPDGSAPVGVAAAAEGVWFADIAGGRVGRVDPSGRLHHTGFDATSRPHAVAADGAGGCWVTLWGSGELARIAADGTVTIRALPGHEPHGLWVSPTAVWVAMESGALVAVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKJ6</accession>
    <name>A0A011AKJ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosom_S30AE_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079045_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="27307" checksum="D0F173566AA3C9BC" modified="2014-06-11" version="1">MSVHGDAPVVLAELPVEVTTDGYFAPDVPDHARRKVRAALRYCPYPILRASVRMVRFPDPALPRPVVSNALVNVNGRLVRVQTTASSAREGLDALQHSLRTAIERIDRHPGRRGHGQRPVVPDAGDDPEIHPHGTYAPVSCTVDEAIADLDALDREFHLFHDVDTDVDTVVFRAGPTGYRLAQVRHQPLEVTPATPVAIEVGDAPRLSVGDATERLRCSGQPWVLFADSATGRGTVLHVGRDGHYGLVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALD8</accession>
    <name>A0A011ALD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protease II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852673.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3912"/>
    <dbReference type="HOGENOM" id="CLU_014819_4_0_11"/>
    <dbReference type="OrthoDB" id="865015at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="PTHR33938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458566" evidence="6">
        <location>
            <begin position="34"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="544" mass="58652" checksum="6FDFDE010CE22484" modified="2014-06-11" version="1">MRRILLVNNRSRGITAGVVLITALGVAPVPAAAAVSREPRCAELAGQAIPASVIGGPTRGGRVESAAPATKDVNGETIGYCSVRAVLHPVDRSAPDITFQIGMPAGWNRRTLMFGGGGYDGTVPDVTQNVPFGRPDQATPLARGYVTYGSDSGHRAGPTGSLDGSFGVNDEALRNFAAGDALKKTHDAATYLVRRAYGAKPDRAFFAGGSTGGREALVVAQRWPDAFDGVISAYPAWNNAAEILFLGHLARVMSRPGAFPGPKQQALLYNRVMAACDGLDGVKDKIISNEKGCRFDPRVLRCPSGQDCLSDAQVTAVIAASTPFRWPYRVASGEQHYPGFPLLSGADMRTPSLGFGTSAPADPMPATSAYGFQFWDQWVKFFLTRDPRRNSLTIDPARPGKWLSRISELSAVQDRNDTDLRPFARSGGRLLLLHGAADELVSHRSTNDFYERVLDTAGSRTTREFLRYYLVPGANHANVGAPAFAANWDSLTALERWVGNGRAPADPVVTDSRDGRTRPLCEYPRWPKYRSGDPARARSFECVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALM3</accession>
    <name>A0A011ALM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852792.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="24126" checksum="59ED1605316F4578" modified="2014-06-11" version="1">MLLVVDDDSRVRTVVSWQLESEGYAVQVAADGATAWRRIVEQRPDLVVLDLSLPGLSGLDLLRRLRENGDRTPVVVLSGRSGEGDRILGLDLGADDYLVKPFSPGELAARVRSVLRRTGPAPVAPAPRTGLRIDPASREVELDGEPVPLTAREFDLLAFLAGHPRHVFTRAQLLEQVWSSSQAWQSEATVTEHVHRLRHKLGHRFLVTVRGVGYRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALQ1</accession>
    <name>A0A011ALQ1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">CryarDRAFT_4063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852866.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4038"/>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_11"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="37919" checksum="2F578EC0809349E6" modified="2014-06-11" version="1">MRSVLAAGFVAFVVSIFSTPVAIGHLRRLKFGQEIREEGPRHHQSKRGTPTMGGIVFIAATVIAYLVTDVVVGDHRISPTAVTLLGLFVGMGAVGFVDDYIKIRKKRSLGLNKRGKLIGQAVVAAGFAVLALNLPDGNGYPIASEKLSFTRDLDWAQLTQVGAALFFVFVVIAAANGVNLTDGLDGLATGPSIMVLLSYVLIGLWQYRHICAEVGGPACYTVRDPLDIALVAAAAAGALAGFLWWNAPPARLFMGDTGALGIGGLIAGLALTTRTTLLLLILGGLFVIVTMSVVIQIISFRSTGKRVFRMAPLQHHFELAGWPETTIVARFWIVAGFFVAAGLSLFIADFLELFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGL4</accession>
    <name>A0A010YGL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase with chaperone activity, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848003.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.414"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_11"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="843" mass="93108" checksum="55895731C5C46016" modified="2014-06-11" version="1">MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEGVRQQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKEPAGSGAPAEGTPSTSLVLDQFGRNLTQAAREQKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKDKQLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDEIHTLVGAGAAEGAIDAASILKPMLARGELQTIGATTLDEYRKYVEKDAALERRFQPIQVGEPSLAHTIEILKGLRDRYEAHHRISITDGALVAAATLADRYISDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDERIAGVRREKESAIDAQDFEKAASLRDKEKQLLGQKAQREKEWKAGDLDVVSEVDDEQIAEVLANWTGIPVFKLTEEETSRLLRMEDELHKRVVGQEQAIKAVSQAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSKALAEFLFGDEDALIQLDMSEFHDRYTVSRLVGAPPGYVGYDEGGQLTEKVRRKPFSVVLFDEVEKAHPDVFNTLLQILEDGRLTDGQGRIVDFKNTVLILTSNLGTRDIAKAVSLGFQSGNDTSSNYERMKLKVQDELKQHFRPEFLNRIDDTIVFHQLTEEEIVEIVDLMLARVDTALKNKDMGLELTDGAKKLLAAKGYDPVLGARPLRRTIQREIEDTLSEKILFGELAAGQIVVVDVTGTDEADRTKGEFTFRGAEKPAEVPDTVTAEIASSGEAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGL8</accession>
    <name>A0A010YGL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848016.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085471_0_0_11"/>
    <dbReference type="OrthoDB" id="1872498at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="26578" checksum="4FFF2D78B133B464" modified="2014-06-11" version="1">MSRWTTRSAGGTGRRAGTLITLGLAGAFALTGCSAGQVAETAIKVPAIPGVDAKVGDIAIRNALIAFPSEGYDWASGSSVPLSVRLINNGNTADRLISASSDLSSSVVLQVVPEGGQATTAPSESPSAAVSETVSPSAGATTGGEATPSGPVVTGTPEPTLSNGQPSPAPSRGTPSPVVDSPIPTASPGAALPLDLPARKLVDLEVGGPQLVLTAISEKIDPATVVAVTLTFERAGDVTLRVPFAPPGTPLPRESVSHAGEDAEGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI01</accession>
    <name>A0A010YI01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848686.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.946"/>
    <dbReference type="HOGENOM" id="CLU_031506_4_3_11"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="28828" checksum="D02CBDF3C158B5B2" modified="2014-06-11" version="1">MSPRSGEAPPSPAPLGVPVLDSHTHLDIQGGDPAAALERAAAVGVTRVVQVGCDVPSSVWAADLAAAHPSVAATVALHPNDAPAPVGAASLDAALDEIAALAARPEVRGIGETGLDYYRTGPEGVAAQEKSFRAHIQLAKQHDKALVIHDRDAHADVFRVLESEGAPSRVVFHCYSGDAEMARRCADAGYVMSFAGNITFKNAQSLRDAAAVAPKDLLLVETDGPFLTPMPYRGRPNAPYLIPLIVRALAEVRGEDVDELAAAIWSTGERIFGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJQ3</accession>
    <name>A0A010YJQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849372.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1518"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="35739" checksum="1C57259197C9DCDE" modified="2014-06-11" version="1">MKYARLGRTGLEVSRICLGCMTYGDPDRGNHSWTLPEDESRPFIRKALDVGINFFDTANVYSDGSSEEIVGRALRDFAKRDEIVLATKVNGRMHEGPNGAGLSRKAILAEIDNSLRRLGTDYVDLYQIHRFDPQVPIEETAEALHDVVKAGKARYIGASSMWAWQFAKYLHVAEKHGWTRFVSMQNHYNLLNREEEREMIPLSIDAGVGVIPWSPLARGRLTRDPEVTTNRSESDAFGSRLYDVEADRAVVAAVARIAEERGVPRAQVALAWMLARPGVTAPIIGASKLSHLEDAAAAVDLDLSADEIAALEKPYVPHAVVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLG9</accession>
    <name>A0A010YLG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850230.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2136"/>
    <dbReference type="HOGENOM" id="CLU_083287_1_1_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="16399" checksum="DE2E153419ABA134" modified="2014-06-11" version="1">MSKRKLIEDVAVELRLLQRSFDAFDEAAASTLKLNRTDLRALDVLLASDEHLTAGELSNALKLSPAATTTVLDRLQRAGFAARIPDPGNRRRVHVAVTEAARAAERELYAPVGEAGAEALSGYDLDQLATIHHFLRTARGVQEAQAARLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMX3</accession>
    <name>A0A010YMX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570109.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2638"/>
    <dbReference type="HOGENOM" id="CLU_075662_0_0_11"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="23961" checksum="6F05922E49CAE99D" modified="2014-06-11" version="1">MNVQLLVLAKAPVPGRVKTRLCPPCTPVEAAALARAALQDTLDAVRATPAQRRVLAIDHPGELGDLSLRGFEVITQRGPGLATRIAAAFADAAAPGLATVLVGMDTPQVGPDRLAAVGARLVHVGVDAVLGPARDGGWWTLGLHDPRHADLLRDVPMSRPDTGNATRVALRAAGLRIAAAPVERDVDTAADAAAAAAAAPESGFAAAWRQITARAKDTRTDTRTAARAKAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMX8</accession>
    <name>A0A010YMX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850925.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2643"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_11"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="36340" checksum="F2975E271264FB6D" modified="2014-06-11" version="1">MRVLVTGGAGFIGSHVVESLARAGHHPVVVDSLAPDLHPAGAPAVLDGHEIVRADVRDADAMSAVVRGVDAVVHQAARVGLGVNVADLPAYVADNDLGTAVVLASAAEHGVRRLVLASSMVVYGEGSYRCARHGTTSPGPRAAADLSAGRFEPTCPRCGQTLEPGLVDEDTRLDPRSVYAATKVAQEHLAAAWARDTGARVVALRYHNVYGPRMPRDTPYAGVASLFRSALERGEAPRVFEDGAQRRDFVHVTDVAAANVAALRALSTLADGSLLPCNVASGEPRSIGEMARTLAAAFGGPAPVVTGDYRLGDVRHVVASPARAAARLGFVAAVPFTDGVTHFARAPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN81</accession>
    <name>A0A010YN81_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851056.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2730"/>
    <dbReference type="HOGENOM" id="CLU_082760_3_2_11"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="54"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="19863" checksum="98DA4546A93009CE" modified="2014-06-11" version="1">MRIDEVDPADLSADQRPLYDLYTTGRRVAPGSPFTLVGPDGRLQGPAAIWITHPTFGTALQQLGSTVRWGSALPARAREIAILLVGHHHRSEFELYAHRLAGAASGLSPDDLTALSEGREPAGATDVESGVFRATTSMLATGTLTDDEFRDATGVLGAPGLLELTTIVGYYNLVALQLAVFDVRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPC3</accession>
    <name>A0A010YPC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipid N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851566.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3127"/>
    <dbReference type="HOGENOM" id="CLU_085338_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="4">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="21098" checksum="E34A1A0973913D9A" modified="2014-06-11" version="1">MTAAALERTTFLREFLRAPFTVASVTPSGSMLSEVVTAPVPSTGDPVIVELGPGTGSFTAAIQRRLAGRGRHLAVEINPRFAKRLAAGYPQIEVAVADARRLPDVADQGSGDVIVSGLPWAAFTPDQQDDLLDAVTAVLAPHGTFTTFAYTHAQWAPSARRLRRLLGDRFEEVVLSRTVWANLPPAFVYHCRQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ21</accession>
    <name>A0A010YQ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3232467_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="43" mass="4925" checksum="8B37AC2C8F5C4F12" modified="2014-06-11" version="1">MLLFLVGTLLLGDASVLRWLLRRYAGPIFFLSSPFILWRCGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR24</accession>
    <name>A0A010YR24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570620.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3809"/>
    <dbReference type="HOGENOM" id="CLU_062618_6_3_11"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="83"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28807" checksum="D13FA893387566D9" modified="2014-06-11" version="1">MDTTQADAIPLQVARLDESRLVGSDRVLAVLKELARHPDGAGLEELTRVIGSPKPTVHRALASLRRAGLADQDDRGRYVLGDEFLRMAFAHHELRPEQVRIRPVLEALAARFGETAHYAVLDGREIVYRAKVDPPTGAVRLTSTIGGRNPAHATGVGKLLLAYRLDSLDAVRDWIGGEPLVRRTANTLGDAGALYRELRLSRERGYAVDDQENEVGINCLALPVYATSPATPSGAISVSALTYRTPLSTLTDAVEDVRRALGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV28</accession>
    <name>A0A010YV28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase family protein, LPXTG-site transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.25"/>
    <dbReference type="HOGENOM" id="CLU_045680_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="27372" checksum="C4B9AC615D11CEEE" modified="2014-06-11" version="1">MEPGIHSWRPSGRDAAGVRRANGVDARHEPESLIRRSIRTFGEVLITLGLVVLMFAAYEVYGKAYQVNADQDRLNAQLDQQWAAGPTPGNSATPAEALPGQAVARLYIPKLDKKWVVVEGVDPDDIKLAPGHYPDSQMPNEVGNFAIAGHRMPSIFWDLDKLQNGDTIVLETQTDWYVYSVKKNFITLPTQVSVVSSNPENPGQKATAKMLTLTTCNPKWDNYERLIIWAEQTKAQPHSAGKPPEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVS6</accession>
    <name>A0A010YVS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056544_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="28367" checksum="7F06A292BD9200F0" modified="2014-06-11" version="1">MASGSGCADVHVPCAPSPKTTSKRAPRRRVGLPACPRRTSPAFALQRANTRPAANGRSNRPRMPVLVVRNPPYPMAPMSGGRSDGTAARAAEETRPPADAALASWLPVRPGLRSNRGRGQLEQRRPDARHAPVNSVDPKNGKAGPLGGDPACRCGWSGWRDSNPRPLRPERGRRSPHSLAGRVMAGGRMWTAVNERVWPTLTAAARSQFTPNLGRRECLRRSALKAIVRWAGDPNSRSNVRTIEVSPVAVSSGVRPDWCAWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVW6</accession>
    <name>A0A010YVW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123091_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="26271" checksum="E20DF16BBEABEB7E" modified="2014-06-11" version="1">MTRRRPPLAAHRPPSEVSPGAVPTQVVSTSGSALSLRVGGDGVVLGHQSHRVPLGVRLFRPAPTRAVFVGSLACAQLIAFRVLTTGAHVIVSTARPAKWAPIAAHGTPVQPVATTPEAATTPEATTTPETSQPIATHPKSGRRTQPLLYIDDAPPYGRPPDLPTTPWTTTLTIREALTHREAALVDHADLLLLQPLTPEETGLLPQKTEPHPPADTLTVMSNHGVRHGRLGVTPVEHHYFGSALRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVZ5</accession>
    <name>A0A010YVZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase/secretion neighborhood putative DEAH-box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.315"/>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_11"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="71"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="790" mass="84118" checksum="282B81B2B07A7EFF" modified="2014-06-11" version="1">MSTQLSAETSPDLWLQRVRRGRTSDPVTHVEHLPARAAVHVDWPAWVPPSLRDAYAARGVSRPWSHQVEAAEAAFSGESVVVATGTASGKSLAYQLPTLSALLSDPRATALYLSPTKALAADQLRGLLDVAEAVNGGVRPALYDGDTADTEREWVRAHSRLVLTNPDMLHRGILPRHEAWASFFRRLRYVVIDECHSYRGVFGSHVAHVLRRLRRVCARYRSSPVFVCASATVSDPGASAFSLVGLPVRTVTDDGSPRGATTFALWEPPVSPLVGERGVPTRRSATAEAADLLADLVAEGARTLAFVRSRRGAEAVALGAKRALAEAVPELVEQVAAYRAGYLADDRRELENALRSGALLGLASTNALELGVDVTGLDAVVLTGYPGRIASLWQQAGRAGRGSRDALAVLVARDDPLDSYLVHHPSAVFGRPVEATVLDPSNPYVLGPQLACAAAELPLTEADLPLFGGDAARYALDGLVAAGVLRRRPAGWYWTSRGRPDADLRGTGGEPVSIVEASTGRLLGTVDAGSAPSSVHTGAVHLHRGETFVVEELDLDDLVALVRRAEPDWYTQSQDVTELDIVSVEHQVEADGVQLCFGTVDVTNQVVSFQRKRILSGEVLDEQPLDLPAQQLRTRAVWYTVEESVLALAELDLPDVGGAAHAAEHAAIGLLPLVASCDRWDIGGLSTASHQDTGLATVFVYDGHPGGAGFAERGFDAAVEWLTATRDAIVGCECSTGCPSCVYSPKCGNGNDPLDKAGAVRLLTAVVDRVRRAAPRQSTFGVQVGGSHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWS3</accession>
    <name>A0A010YWS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569675.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070819_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="30423" checksum="0ACE7F9FE6FBCBFA" modified="2014-06-11" version="1">MRIVLVTATELPVPEDVELPVLQAAASRAGLTADVACWDDPAIEWAGYDLALLRSTWNYPSHLERFQAWVDATAAVTRLVNGPAIVHWNSVKTYLGDLHAAGVPTVPTTYLAPGEPVELPGYADIVVKPTVGSGARKARRFRGGTLSAATAHVKWLHAEGHTAMVQPFQYRVETDGERALVHVGGEFSHAIVKGAVLSSVTGVRGEHAHPDVRPYEPTAAEREVALAALAVAPEAPLYGRIDLVLDDTGSPIVMEAELIEPHLFLEHGPGAADRLLTAVKDLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWT1</accession>
    <name>A0A010YWT1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848378.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281771_0_0_11"/>
    <dbReference type="OrthoDB" id="1629615at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="24188" checksum="55982E998DBFA4DF" modified="2014-06-11" version="1">MPTEPTTSSYALLGLLALRSWTAYDLTRQAKRSMRLFWPRSEAHIYGEVKRLVRWGYATAATERTGNRERTTYAITPAGRDALRDWLATPPAGPQLEIEGLLRLLLADQGDRGDALQAVRATRDAVATSYGIGIDQMRAYVEGEGPFPDRVHLVALLARFYADFAEAMLDWCDAAEAEIEAWPDVRGVGLTDVTRRGLEDAIARYDRRVLSARRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXF8</accession>
    <name>A0A010YXF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848643.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127611_0_0_11"/>
    <dbReference type="OrthoDB" id="1622859at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26335" checksum="3CFC2783A17DF1A5" modified="2014-06-11" version="1">MSQPDSSAPSQMPVPTAILLPRPATDPGPEASLPPRPGGWSSSTVGALVAVYTRLGDRVAVVDPNLSGTVTPVTELLGRRTAVLPMREFTPSAGRRTRLVLARLPEPGVPAGSALGEWMHRVARSLTERGYLAVTVDPFGAYPAQRERSGEPGRARYRDHTTSVIAAARAAGLRYQQHLIALHTTVLEPDTRERSGPGAPDASDSGGRRAPVHERLHTDIFVFAAHVAAIPARPQTTAHRQEMRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXG7</accession>
    <name>A0A010YXG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.908"/>
    <dbReference type="HOGENOM" id="CLU_041762_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="372" mass="40430" checksum="0CC48FABE32F28B0" modified="2014-06-11" version="1">MRWLAFGTYDVQRHPRVAVLLDGLRESGEEVVEVNDPLPLDTAGRVQMLRQPWRLPILAWQLGRCWSRLISGARKARRSGDVDAVLVGYLGHFDVRLARFLFRKTPIVLDHLVSAAGTATDRGLAGSGGFKQKLLRWIDRKALGSADVVLVDTPEHLDALPADVQPRAVVTPVGATKPWFEQYRAEASTPEQLRVVFVGLFTPLHGTAYLGDALAELADDPRIVVTMVGKGQDHADCKERAAANPNVTWVDWVRGEELPAFVAGHDVSLGIFGTTAKAQNVVPTKVYQGAAAGCAVLTSDTPPQRAMLGDTAVFVPPGDASALAAALRTLADDRDLLERHRRQAHERALEHFTAVGVVAGLLDRVRQPAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXJ4</accession>
    <name>A0A010YXJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569745.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010896_0_0_11"/>
    <dbReference type="OrthoDB" id="1687880at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="28577" checksum="01BA2C279AFC782F" modified="2014-06-11" version="1">MGISNEALSTEVPTLATPPAEPVLFDWDGPAPAAPVDQEEFPADVEPDAPHEMEGAVPLPLDLPEEPPGPPPGSDRFVDEGLALVLRNRLHTERPGAPAARRVAAHQVALPEPAPRTGPALPLRPPGAGLAAALALGLVAAFFGWVSAAPFWLAQGVGSTEKVTVVRCDDRCEGLVGARTVRLVDVDRSDRKPGTTVEARMLDGDDVAYASPVAGLHLRWMLGFVLVVACGAGVGAATGVPRLRREGTQRVATLWALSLGGPALLALIPVVAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXR6</accession>
    <name>A0A010YXR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1034"/>
    <dbReference type="HOGENOM" id="CLU_054549_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="24011" checksum="7F9EA2CC2F402E7B" modified="2014-06-11" version="1">MLADLVLPVPCVACGAADGPLCAVCTPHALHTAPFPVAAGARPGGGVPAACVAAGAYRGALRSALIAYKERGARALARPLGVRLATAVEPVAEGRGRLLCVPIPSSAAAIRARGGDHVVRLARFAVATLRQRGFGAEVARLLTMRRVPTDSVGLGAAARRANVAGAFVAAPGRVGALRAPTGSLRGRTTIVLVDDIVTTGATLAEGYRAVAGIGLPVAGAAVVAATPPRGATVYMVRDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY57</accession>
    <name>A0A010YY57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848930.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_3_11"/>
    <dbReference type="OrthoDB" id="1678187at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="66"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="25414" checksum="49368D4423CBD83B" modified="2014-06-11" version="1">MSGKASNRARRVAAEQLAKQRAAERRRRAIVVSVIALAVLVLAAGIGVTFYLSNKPENVALPRAATTTGLTVGKDTAPVTVDVYLDFQCPICKTFEDESGKTLQKYVDEGVVKIAYHPVAYLDRFSSGTKYSSRSSAASGCASDAGKFPEFLTTLYANQPEEGGSGLTDATMVSLAEKAGITGDTFEKCVEDQKYADWTKSVTDEASKAGVNGTPTVKVNGTALESPTTAALTAAVDAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY62</accession>
    <name>A0A010YY62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HD-GYP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1193"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="22177" checksum="E82F1DF9C00DFEBD" modified="2014-06-11" version="1">MSTERKRAKVLLVDDRPENLLVLEAILQGLDHDLVTAPSGEEALKRLLTDDFAVILLDVQMPGMDGFETAEHIKRRERTRHIPIVFLTAIDRKPHHAFRGYATGAVDYLAKPFDPWVLRAKVSVFIDLWEKNRLLLERTELLQQRVHSTEVASTERGSALDRARLRVQEALARCEATDPETAELLRAALHDLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYV5</accession>
    <name>A0A010YYV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849258.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860179_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="6963" checksum="8026A2C61785FD9B" modified="2014-06-11" version="1">MFFSGTDANALVRARSARHARDAWARLVDEKGERRAFAELASHAGGSDAAVHTLTRHGIETDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZR0</accession>
    <name>A0A010YZR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849708.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1743"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_0_11"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="15632" checksum="C37091BC328D49A1" modified="2014-06-11" version="1">MITNIAITSVFVKDVDASKAFYLDVLGFVENADITLADGSYRWCTVSHPSQPELAVHLTVPGPPHSPEMVAAINRALDEGGMHGLGLNVDDCRKTYDDLRAKGVEFIQEPEERPYGVEAVARDNSGNWMVLVEHKAFSPADFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1I2</accession>
    <name>A0A010Z1I2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850520.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="19471" checksum="A82289C26D752950" modified="2014-06-11" version="1">MTDELLVVRSQLGERDAFADLVRAWHDPLTNYVRRMLGAGRSDDVVQEVWLAVVRGLPRLRDPVRFPPWLFSIARRAVTNRLRDEYARPELGAEVEGVGPDIDDAVLDRAAVVASVGALPVREREVVVLFYLLDLSLESCAEICGIPVGTVKSRLSRGRRMLRDEFTQKGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3S8</accession>
    <name>A0A010Z3S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase, DNA invertase Pin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725716.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3135"/>
    <dbReference type="HOGENOM" id="CLU_022362_0_0_11"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="163"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="738" mass="81865" checksum="229519ACB71DE537" modified="2014-06-11" version="1">MRFAFAGRVSTEDQQDPEASRLWQRSRSEALIAPVGGEIVAEFLDIGMSRSLPWSRRPRAAELLAAIRDPKRGFEAVVIGEPQCAFYGNQFGLTFPLFVHYGVELWVPEVGGAIDPGSDAHDLVMQIYGGMSKGERNRIKIRVRSTMAAQAATEGRYLAGRPPYGYRLGDAGPHPNPAKAADGKRLHVLEIDPVAAPVVIRIFAEYLDGRGFFAIAQGLARDGIPCPSAHDRKRNSHRTGVAWSKSAVRAILLNPRYTGREVWNKQRKDEVLIDVEDVALGHETKMRWNDKDTWIWSTKPTHPAIVTPEDFEGVQTLTAAGARRPNVRKTRTMQRHYLFSGRVRCGLCGRLMQGNFNNGRNHYRCRYPADYAAANHVEHPKTVYLREDVLAGPVDEWLSQAFAPAKLTETLTAMSEAEDTTDDAALAAAKEAIQSCGQRLQRYRAALEAGTDPVLIQQWTAEVQAERVRAEARIRELTGRTRMNSEDINALVSALGGIRRILIDSDPADRAQVYRSLNLDLTYHPSRRTVTAEARPEGHVLMGCVRGPSRTMGTPPLLLTRDLSLGPARSPRVRIQSARAHDRETTWGTALLETCVHQDAVQAALGVDPETGGLPRRLGLTLAEGITSGRSRVRAVLLRQRVERRSTPYQLRRRAIRARRDRRHAVRHVSRLGPAAQVWDGATVGVPELDRAMFRQFASLPEHPSDLAVVRPIEPAALDMAQRIRATGWTAPTNVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z428</accession>
    <name>A0A010Z428_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-glucoronosyl and UDP-glucosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851739.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587780_0_0_11"/>
    <dbReference type="OrthoDB" id="1485440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="48750" checksum="25B7F659383BDB6C" modified="2014-06-11" version="1">MDATRRPILFSCTESAGVFNPHVLLAGELAGRGVDDLWFATDENRRGDVEAASDKTDVRFLSMGEVNPRDVVTNYDDRTYRAVTQPEPFKAYLARVKQSLDLDGHYARYHRLAAAVDEIRPALLVINNLNMHAVHLAVTRNIPFVLVAPCLPSDVLKATLPPEYPAPGTGLPLRMDARQQQANRRFRRRKRTMFLDGTVLKHSIAFEKARKAAGIDAKVLNSAAIMDQVELILCFSVFGLEYPFDATDKLRMLGAAVPPVPDGPADDVVTWLDAHRSVVFVSFSSGMRLTEAEIVAVTEAARRLGDHSVLWKLPPSQQALLGDLPPNLRVVDAVRSPAEVLAHPHVRAFVNHGGSNSVNQGLYFGRPLLIRPLWLDGRDHAVRVADSGVGLTVDALTADALHTALTRLLTEPSFTERADHLGRAQRSAGGVPAAADLILETPSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z461</accession>
    <name>A0A010Z461_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851792.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3280"/>
    <dbReference type="HOGENOM" id="CLU_041420_1_0_11"/>
    <dbReference type="OrthoDB" id="775687at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="369" mass="39596" checksum="78323067AF51D357" modified="2014-06-11" version="1">MIRSEQNPPEIVVGLVATPPDHPARVTAHLAAELADRLGERTDGEVRWTVREGWGEVAPRRDGGVEALLDDLARRRTDERWDLAVCLTDLPLHTERVPLVAQTSARRRVAMVSLPALGLRQLPAVRAVVPDLVDRLLTDASDDRVPPAGWAPAELAHRVTAVHRMAGEGDAGEVRYVASRLAGRARLLIGMVRANRPGRALLGLSKLLVGAFGTAAIALTNSSVWQLGQGLSPLRLAVIMVLGLTGLVAWLIVAHDLWEKPDQDTSPELARLFNQGTVLTLALATAVSYLVLFAGTMLAGALLIDTSVLEQTLQRPVGLNDYLAIAWLISSLATVGGAIGSGLEDEETVRAAAYGYHPDPGGWKDERDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z572</accession>
    <name>A0A010Z572_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase,'ATPase, histidine kinase/DNA gyrase B/HSP90-like',GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852331.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3654"/>
    <dbReference type="HOGENOM" id="CLU_034370_1_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="56"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="224"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="583" mass="62288" checksum="8E2DC9E0FC395EC9" modified="2014-06-11" version="1">MSDDSEESAGPVPSLSRLRLDTLLRELVVRAEDLLDTQSRLHRLLDAVVSMASDLSLPDTLRRIVELSAELAGARYAALGVIGPERLLVEFITVGLDTQTRVAIGDPPHGKGILGLLINEPKPIRLHDLGEHPESYGFPPNHPPMTSFLGVPIRVRGTVFGNLYLTEKRGGEDFSEEDEDVVIALAAAAAIAIENARLFEQTHRREQWLAASTEVTDRLLQGADFTETSGLIVAKAVEIGQADAGFLLLRGEGEPQDDPRLTVRAAFGDGAHHFLGASYTVPSARTALFAGDGSPFRFDGGGAHPFVPRDPAPVPDRFLGPGAIVPLAAGGRVFGVISVARVEGRATLSDADTRMLHAFAGQAALALEFSRAASDRQRLAVFEDRDRIARDLHDLIIQRLFAVGLGLQGVSTMAGRPEVTDKLNGFVDDLDDTIRDVRKTIFSLQEPVERPSGLRGEVLRVVSGSAETLGFEPRLHLVGPIDSAVPDAVRPDLLAVLGEALTNVARHARASSAEVELSVDVGSGRVTLVVTDDGVGPGADDTPGHGTVNMASRAHRYGGDCTFEPQAERGARLCWSVPLRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5B6</accession>
    <name>A0A010Z5B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852409.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3695"/>
    <dbReference type="HOGENOM" id="CLU_060721_1_0_11"/>
    <dbReference type="OrthoDB" id="1584529at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046249">
        <property type="entry name" value="DUF6282"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19799">
        <property type="entry name" value="DUF6282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="32470" checksum="959D84F4E9A71E17" modified="2014-06-11" version="1">MSETPAIVKLLNGCVDLHCHSGPNPFPRRIDHAEAGKDGERLGMRGVLVKSHHHNTVMDLLAMSDRLATIRTPVFGGITLNSMVGGINPQAVAMSLRMGGRAVWFPTFSAGRHIDCHPEGVGFPTASVEVPSSRVDVHQADGELIPEVHEVLDLVKESGAMVTGGHMETESITQLFAAAKDKGITRMLLNHPDYVIGADEAKCRELVGYGAFIEHETGFYDPEGTKKWDPKLLLDWIEKIGPEHTVIASDLGQKDRPLPVDSYLRVATALLDLGLDERSLRQIFCDNPAFLLGLEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5C6</accession>
    <name>A0A010Z5C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852415.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3705"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="609" mass="64761" checksum="3795FF9B60B9178F" modified="2014-06-11" version="1">MSEATTEPVARTVAAAFRLAWLAAPAQLAGAVVVAVLSAAAPALTAWLTRATIDGIVTSLDTGELLVFVAGLGAVGIAAGVLPHATRYAQAEVGRRSTVRALDELYRAVERQAGLRRFEDPPFLDRLRMAGNGGRAPGELCGEVLGAGAGLLGAVGLIAALAVVSPLMTLIVLAAAVPVLVMELRLARRRAAVLWRMSPTARREFFFSHLLGHPVAAKEIRLFGLARFLRERMLTEHRAIDVAQRAVDRRELGTQGGLALLGACVAGGGLVWAVFAARAGQQSVGDVSMFVVTVAGLQATLVGLVGSLAGGHQSALLFAHHRVVLAAETDLPVPVAPVPVPPLRRGIELRDVWFRYADDKPWVLRGVSFVIPHGASVALVGRNGAGKSTLVKLLCRLYDPTLGSIHWDGVDLRDLAIDELRQRTTALFQDYMEYDLTAAENIGLGDVAAVDDRHRITDAARLAGIDDVLAALPRGYDTMLSQVFTEGDTSDDESNGTMLSGGQWQRLALARALMRGERDLLVLDEPSAGLDAEAEYEVHTRLRRHRAGRTSLLISHRLGAVADADRIVVLVDGVVAEQGDHGELMATAGTYAHLFGLQASGYTRAGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5U9</accession>
    <name>A0A010Z5U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570636.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741639_0_0_11"/>
    <dbReference type="OrthoDB" id="1815612at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="37832" checksum="12F293514953E371" modified="2014-06-11" version="1">MTVLDTLDTAYTDRFARARAWRADGGTVVGYVGADTPVELVTAAGALPVRLSGRPGRPLGHAREYLGAGVDPATLSILAGLLDEAHPLDLLLVSHDSEASLQLFYALRELRRLGLEPQLPPTWLVDVLHLPHRSTATYNLVRLRELRSRLERFAGATIDADALAAAVATHEEIRSARRVLATLRAPGRRALTGVEALTLVGAGSTLPAGEYLPLLRAALAELAGRAPRPGVPLLLTGSAHDEPGVYRSLEDDGWLIVGEDHSWGDGAGEPPLTPPTLEGLAEWYQGRTVSEAAPAAVARTGAEGVLSYARTHDDAPLWDFRALAAAVPVPAALVAGQEYGTVDLAAVRAELKDGGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z633</accession>
    <name>A0A010Z633_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039048_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458958" evidence="1">
        <location>
            <begin position="23"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="488" mass="53557" checksum="3AA973F425370AA0" modified="2014-06-11" version="1">MTRSRQLAIPRQRSGPAKRTAAVAPAYTHVVPPRPFVPSVSDTRCRSMVSKSSYYFSTYWWRTKNRYAATGIPNITWTDAYATGMEVKVREACNAALTMAVCAGWGGHLPSAISLDLGDVRNRAARLVVGVARRHVTYGTGGARWGGNWQSAYWAYSLGLAAWLLWRTQLTNAWDREAVCAVVEYEADQQLHRNRPEIWRDSTGVDQPFSGVYRVGIRSGDSAAEENMWQATVLDLAATMMPGHPRAAAWRAKAAQFGIVGAMSRNDLWDTGTDVNGESPNHWTVGTTMASPPPGPAQIGKPGYNWSEQYVVTNHGKRNPDYMQADAMRLALSLHHSLAGEPTPEWVRWNSARIYGAMRTVVYPGTVSPAKPMYKDTASPSLYFPDGSDWGTARHTGFWLWDSLVETHVGPSPFVPVGAVHWGSVHGAAAKAMQDRTGVMPGGQVVRTDLEDKYPGREGWHASSAAFVVLNKALTNAGRLSWTNAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKH2</accession>
    <name>A0A010ZKH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CmpA/NrtA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847615.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.165"/>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_11"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459076" evidence="2">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="348" mass="36747" checksum="921EBBE92A44ACD4" modified="2014-06-11" version="1">MISRRQLLAGSASLGLLGALAACGDDDSEASGTDGVASTLRLGHFPNLTHATALVGIQNGLFAKALGSQTKLETKQFNAGPAAIEQIFAEGLDATYIGPNPTVNAFAKSKGEVIRVIAGSASGGVAFVVKKGITEANLKGTKIGTPQLGNTQDVALRYWLKEKGLTATKDGGGDVKIQPQENAQILEKFTAGQLDGAWVPEPWVSRLVSAGGEVLIDERDLWPGKRFVITNLIVRTEYLKKYPKTVKALLQAHVDANDSIKSDAAGAQKAVSEQIGKLTGKPLKLDLITKAWPTLEFLNDPIASSLITGAKHAEEIGLLDKVDLDGLYDLKLLNEVLASKGETAVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKJ1</accession>
    <name>A0A010ZKJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847647.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1934533_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14049" checksum="7A9F600D82BB294B" modified="2014-06-11" version="1">MRTTTVTYGPAKHTTEMSYQALPAAGLALTPGLSPTGTFNGCWTVRHIGSGLVINDPTGFDGHFSTLAGAYAFAQALVDYFPDVDFTADAEDVRDHLRHDSFALTKALDASLTSDHDDLRLSLSHFEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLM2</accession>
    <name>A0A010ZLM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.591"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="267"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="479" mass="52914" checksum="BBE7B91A904F4635" modified="2014-06-11" version="1">MTGAFTWPTVEAMNRRHQRWEDQARRRGERERRRVQWQERRWEQHARRWEQQAQHWEQHAQRWEKHAHHGENLARRWEATGRRWEARWEHRQSPVGAAVGGVGILTIGGTLLAEQTFEGFHPLDTRGWLLLVAAPLLLGVRRRAPIPIALLVTAVLSAYYLLGYPPGPGFLALLVALNAVQTESRRWAAWTIAVAGFAGFTAVDLTLVAGPTVPIGGLIAAGLWTALVMMGAEAGRAGRERAQEYQARRAEAERSRLEGERRRVSDERLRIAREVHDLLGHHLSLINVQSGVALHLMDARATSEEELRASLSAIKQSSKDALVELRATVNALRGVDEDAPRQPTPTLDRLDDLLAGATATGLEVTLTRRGEPSEALPARVDLAAFRIVQEALTNVRRHAGPVSAVVTLEYGEDVLVVQIDDPGPDGARPDVHLDRIDEPPPGGGNGIPGMRERAQSVGGTLQAGPKPDGGFRVRAELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMB8</accession>
    <name>A0A010ZMB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
            <shortName evidence="8">DHK-MTPene dioxygenase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="8">ARD'</shortName>
            <shortName evidence="8">Fe-ARD</shortName>
            <ecNumber evidence="8">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="8">ARD</shortName>
            <shortName evidence="8">Ni-ARD</shortName>
            <ecNumber evidence="8">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtnD</name>
        <name evidence="10" type="ORF">CryarDRAFT_0835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) cation per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="8"/>
    <dbReference type="EC" id="1.13.11.53" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848568.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.824"/>
    <dbReference type="HOGENOM" id="CLU_125400_0_0_11"/>
    <dbReference type="OrthoDB" id="1964262at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01682">
        <property type="entry name" value="Salvage_MtnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023956">
        <property type="entry name" value="ARD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in metal incorporation in vivo" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in transmitting local conformational changes" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Important to generate the dianion" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="21419" checksum="2D1DAF513E702D3E" modified="2014-06-11" version="1">MTLLTVWADDSPSEPELRTEEPSEIAAVLKEHGVRYEQWPLVDLSDDSTNEEVLAAYQDRIDAVKKTEGYILVDVVQMRPSDDPSWPELVRTSREKFLNEHTHDDDEDRFFASGSGIFYLHVGGKVHAVFCEAGDLLSVPGGTTHWFDMGTNPEYKSVRFFHDEDGWVGNFTGSAISSNFPTYDEIAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZME6</accession>
    <name>A0A010ZME6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848615.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.864"/>
    <dbReference type="HOGENOM" id="CLU_075802_1_0_11"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="25126" checksum="DE248CC7C08BCC73" modified="2014-06-11" version="1">MNEHPELLNGAYALDALDDIERAAVERHLRTCPTCAVEVAEFAEAAARLGGASEAAPPPELRNRVLAAARATRQTPSRVAGLRPPRGRRLAAVAAAVAVLAGAVGTTWWVQETRVGDERARVVAAQQESARVRAVLAAPDATLRVSSDVPSGRFTAVYSASQEAAVLTFGGLGDVPSGKTYQLWRISGEVPRNLSVLPPDARGGSRVVEDLAPGDKLAVSVENEGGAQQPTFPYASVAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZND6</accession>
    <name>A0A010ZND6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="21493" checksum="A3B0D81CEF12752E" modified="2014-06-11" version="1">MSAEPRFRIPMPPDGVWTEADLDALRADVPFRTEIVDGNLIVNPRPSLWHNDVIAVVRNKLVGAAPAGQWAYPDSEIRWIDHGEVRRSLAPDVLVAPKHLRDEKRPFAPPDVVLLVVEVESRSSTRIDREAKPRQYAELGIPAMWRIEEGPRVVEYRLTPDGGAETVQTVTTGTFTTEVPFRVTIDLDTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNX2</accession>
    <name>A0A010ZNX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1431"/>
    <dbReference type="HOGENOM" id="CLU_038663_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="474" mass="52390" checksum="4298927618360E79" modified="2014-06-11" version="1">MSVTAPAPAPKATPAKGRDRYLDTLRAVAIIRVVTYHAFGFAIFPWFPAMGVMFALAGTLMVRSIDKGALAAIKSRFRRLLPVVWAFGAIWIPLMIWHDGAPREWSYGANGDSPLWQLAFWLLPVGDPPGSEWGEVAWGVLWYLKTYLWFVALSPLLLKPFRKVPWLVLALPFALLGLAEVGILPLDDWWGSTFNDVLVYLGCWLIGFAHAEGIIKRLPLPALFAIGGVVIAAGLGWLAGPGNAEALEEGRKAWSVENSSLTLALYSFGVVFILMRYSSRMEWLQRHAVIDRIITIFNSRAVTIYLWHNAAILIAMTVLEQFGIDIWVAWFPLTWVLVGVFVLAFGWVEDVAARRKPELVPGKVKVLAAPLQPGAAAEAAPQSPPMPPTPAPAPAPAQYGNQQPYGGDPRYAPDPRYGDPRQQVPQQYDPRQYPPQQYGPQGRNPDPRAGGHYPSAEYGTSRPRSDDRPDQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP21</accession>
    <name>A0A010ZP21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">CryarDRAFT_1508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849311.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1481"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_11"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="376" mass="40190" checksum="5B4BE65094FB893D" modified="2014-06-11" version="1">MAKDYYGILGVARDATPEEIKRAYRRLARELHPDVNPDAEAQEKFKDVSVAYEVLSDPAKRELVDLGGDPMAPGGGGASGPGGPFTMGFQDIMDAFFGGATTRGPRPRTRPGSDALIRLDLDLVDMAFGVNQELTVDTAVRCTTCSGAGTAPGTHPATCEVCGGRGEVQTVQRSFLGQVMTSRPCAACQGFGTVIPHPCPGCAGDGRVRSRRTLTVKVPAGVEDGMRIRLAGEGEVGPGGGPPGDLYVEVHERPHDVFTRQGDDLHCRVSLPMTAASLGTNINLKTLDGEEQIEVKAGTQPGTVVRVRGRGVPHLRGSGRGDLHVHLEVRTPTRLDAEQERLLRELAKLRGEERPEPMRQQGGFFSKVRDAFNGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP47</accession>
    <name>A0A010ZP47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849349.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1507"/>
    <dbReference type="HOGENOM" id="CLU_043966_1_2_11"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="20563" checksum="CF2E4D27C81460D3" modified="2014-06-11" version="1">MGKIVITTNATLDGVVQDPTGEEGFDRGGWFERFGGADLAEWARVETEEALGAEALLLGRRSDEWFGTRWSSRTGVWADRLNAMPKYVVSATLERPAWTNVTVLRGDVAKEVAALKQAVDGEILVYASYQLGRALLEHDLVDEVRLVVFPVVLGAGVRLFGATGAAKPLRLQESRALGDNLTFLRFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPD6</accession>
    <name>A0A010ZPD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847528.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.105"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="34937" checksum="CC00948AB99D05AA" modified="2014-06-11" version="1">MSLSVSGVSVRFGAFPALVDVELEVAEHEVVAVLGPSGSGKSTLLRVIAGLQEPSAGRVVLDGVDVTRVPPHRRGVGLMFQDHALFTHKDVAGNIRFGNTRADVASLLSLVGLPDVGPRAVVTLSGGEQQRVALARALAPSPKLLMLDEPLGQLDRELRERLVVELRRLFVRLGTTVLAVTHDQREAFALADRVVVMAGGRIAQVGTPREVWEQPASEFVARFLGFTNVAPAVVRDGVADTPWGTVAVAAADGSHPVLVRPAGVLLSTEADDVTGVVEVATFAGERVDVLVKIGDAPSLEAHCPAATAPAVGETVSVRLDPAQTVVLPRNSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPL1</accession>
    <name>A0A010ZPL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3308304_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="39" mass="3932" checksum="8E8CC6E08BC5A8C0" modified="2014-06-11" version="1">MADQKCTTCNGHGSTAHSAGGSGYTYKCCTSCNGTGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPT6</accession>
    <name>A0A010ZPT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569571.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.239"/>
    <dbReference type="HOGENOM" id="CLU_100184_2_0_11"/>
    <dbReference type="OrthoDB" id="1949591at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="17055" checksum="8C3D2E1FBEE2A0A9" modified="2014-06-11" version="1">MVADAALDDGRVRLVLSDQRAGESVLDGAWWPRTRKPLVEFPLLMAEVIAVIGDVERMSLSGSGWLTTPREIPFDRHRVDICWFNPNDQHEVVVLAKNDLVLDLLLIPPAAAPIAAMAAMAAASRGTSAARGSQVLVNHGVLLGRSADPPCPDPRFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ13</accession>
    <name>A0A010ZQ13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569587.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_7_0_11"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="25565" checksum="7A5358C35D5DDC2D" modified="2014-06-11" version="1">MSIPGFPAPAVDVAELTVVRHGQSLSNELLIAANQAGVVDVTGLPARDADVPLSVRGRREAAAVGRWAASLDNPPDLVIASPYQRAQHTAQAAVDALTAAGRAPEFRLDDRVRDREIGILTLLTEARLRADHPEEAARREATGFLYYRPPGGEAHTDMAIRLRSFLTDLGEAAAGRRVLVVAHDSVVVMLRYVIEGLVEADVAAIAASGGIKNGSVTRWERRGWSLRLTVFNSVAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQB2</accession>
    <name>A0A010ZQB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847997.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.411"/>
    <dbReference type="HOGENOM" id="CLU_080440_0_0_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="22609" checksum="C36F504E44FB51D2" modified="2014-06-11" version="1">MAEDTRRRLIDGAIETVRRNGIAGTSARTVAATAGVNQALVFYHFGSVADLLSEACRVATAENVERYHEQFAAVRTLRELLVLGRELHTDQRDRGNVTLLAQMLAGAQADERLAAATRDAIGLWVREIEAVLRRVVTGSPIEPVVDVTGLAHAVSAAFVGMELFEAVDPAGSSAALDALDRLGILLEVADELGPVASSALRRRIRSATAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQN2</accession>
    <name>A0A010ZQN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.550"/>
    <dbReference type="HOGENOM" id="CLU_035969_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="29638" checksum="8FA1F69D3DFBAB93" modified="2014-06-11" version="1">MTGNPEATDQPRPARRASRAVKLDAVCAQATDLALDAAREVGHEMVGEPVGVSADGERLVTHRFAALQPGYSGWYWTVTLARAPRSKHVTISEVALLPGSDALLAPEWVPWSERLRPGDLGVGDLLPTAPDDDRLVPGYVLSDDPELMEVEYEIGFGRPRVMGRLGREETAERWHTSRSGPESDIAKAAPARCGTCGFYLQLAGSLGAVFGACGNLFAPDDGRVVSADHGCGAHSEALVEPAPPVPPAPMALDDDLEVIRTVHTPGSVEDSADAEPLGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQX6</accession>
    <name>A0A010ZQX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.639"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="376"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="538"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="806" mass="84674" checksum="8067773D0C4D3E51" modified="2014-06-11" version="1">MSSRPSAEAEAAPAAVWPVPAPAATGWTAQRPVPVTVAWCLGALVMGVHAIWVYAGHVEASPARLWSSGAPFAVTLLLAAAVLAARAITVGYQRLAWTFFAIGVGLNGAGYFVYDVVSWVGRVPSASLADVVWFPVLPCFTAGIWTLARARVGALRPDVYVGAAAVALLSASLVAAGVGHDVLAWDSDGLRATIVNLYYPTVDMVIVGSVAAVTTLAGGRLGRAWGLILVAVFLTVLGDALLARMVAEGGTGVEVLDPIWSFAGLLIAASAWQRPRRLTHRPLGLPELLTPLVSMVLAVLVLVVAEFAHLPSAVLLLAAGSILLSTLRIALSLRSMLVAAEFHRLALSDDLTGLYNRRGFLRGVEEALAGRAPTAGFRAVLMLDLDRFKDVNDGLGHQTGDRVLSAVGARLSGALGPEDLIARLGGDEFAILTTVPAGQSFEAVVAGLFQAVRQPLQAGRISLPIDASIGVAVESDAPDGTPSERALELLRCADMAMYRAKADRGGWARYDPLGSDQQRDSLELAGELRAVLTGTPTTPAVAADPERSLAPHSADCGWLELHYQPLVAVSGAEGIRAEALIRWVHPRYGMVPPDRFVGLAERIGLVPYLTRHVLQLALDQVARWRAEGAPVTVSVNLSASDMASPTLMDEVLDGLTARGLPPEALTVEITEQTAIGDLDTGRDALAVLRAAGLGVAIDDFGTGYSALSYLQRLPATELKLDRSLTTKIIEDPAAAAIVQACIDLAHTLGLEVVAEGIETQELADALVDRGCDWLQGWLFGRPTPAGPTPATPVYTRAVPGPVPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQZ5</accession>
    <name>A0A010ZQZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850275.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_0_11"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="162" mass="17844" checksum="6AF8444019C54499" modified="2014-06-11" version="1">MTVISTTPDPAAHTLTLVAEFTAPPKAVWQLWADPRLLERWWGPPTYPATFREYDFVVGGEARYHMTGPDGARSNGFWRLTALDEPRSLEFEEGFADQHGEPSTALPVAATRVDLDETPAGTRMTIVFRFDTAEQLEQVVTMGMAEGITLSFGQIDALLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR38</accession>
    <name>A0A010ZR38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3308306_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="39" mass="4300" checksum="BC0207815B876D11" modified="2014-06-11" version="1">MKKTETNKVETVKPGKLGKIEIRKLDKIETTSVNSNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR65</accession>
    <name>A0A010ZR65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432376_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="20694" checksum="1E65179B7A92E061" modified="2014-06-11" version="1">MGDTVSLRDVLDDAQRLAWSSGPLRRVGPLRFGMTTDDVRTALSGTLSLAASQERIPGGGGWAEYELRDPTAFGPAVTTYYDESDRLAGVAVSALCGPQVAVDGLRLVGRTPSRLEDEFRAYLASHDLTLRYSQFAHPWAPELGLVLRVQRAGDLVLSRPVFVAPSWAERCGDTTEGAIPIEEWQTFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRL0</accession>
    <name>A0A010ZRL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848625.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.882"/>
    <dbReference type="HOGENOM" id="CLU_022601_0_0_11"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PTHR18896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="533" mass="59829" checksum="00AF16F2F884A41B" modified="2014-06-11" version="1">MPLDDWFLTADERGNPSTRLDSRHPDGIAWTTGNEVRPLVHGSTYFADLLAEIDAAQKGDILFFTDWRGDPDELLAEPDRTVGSVLEDAARRGVVVKGLVWRSHLDKLQFSAEENRHLGVEVEEAGGEVLLDMRVRTGGSHHQKFVVIRHPGDQDADIAYVGGIDLGHSRRDDGDHQGDPQAQPMPDVYGDKPPWHDVQVAMRGPAVGDVDTVFRERWEDPSPLSNNLVRVARDLITHRDITPDPLPEQPPDPSPRGTQAVQILRTYPHRRRNSYPFAPDGERSIARAYLKALKRARSLIYLEDQYLWSEDVAACFAEALNSNPDLHLIAVVPSFPDQGGLSTTGENLGRNRALEKFRAVAPDRVAVYGPENRDGTPVYVHAKVCVIDDIWAVVGSDNLNRRSWTYDSELSCAVIDEERDRREPQDPAGLGDGARVYARDLRLLLSSEHLELQKDEVDALSDPHAAFRAFKESADALDAWHKDGKSGPRPKGRLRPYTPEKLKPFAGFWADPLYQYLLDPDGRPRKLRRNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS17</accession>
    <name>A0A010ZS17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569777.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1045"/>
    <dbReference type="HOGENOM" id="CLU_055284_0_0_11"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="33806" checksum="5E7CE72A0C95ED45" modified="2014-06-11" version="1">MTRRGLVIGAGGVLGFAWATGALAALERAEGFDCRSVDALVGTSAGSILASLLGCGVPVESMVRHQQGISAPGDPVVDYDENVDGAGPRPPLPALAFGSPGLLWQAARSPSSMSPMVALSGLLPRGRAAHTGVRRLIGSVLPCDEWPDRPRPWVVAMDYRSGQRVVFGHDEAPAAPLADAVSASCAVPGWFAPIEIGGRRYVDGGTYSTASVDLLAGLDLDEVYVLTPMASFAFDAPTSFAGRLERRFRRLLAQQLLREAELLRASGTRVTLLGPGPEDLAVLGSNLMDAKRRADVLETSLRTSWAALRPDPGERSLRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSY9</accession>
    <name>A0A010ZSY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">sn-1,2-diacylglycerol ethanolamine/choline phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076605_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="24859" checksum="2322151DCDC8D83B" modified="2014-06-11" version="1">MLLQTAVLGGLAAGVGLGTPGWLAGITFAVTTWALLTSALLRSGAASLGPANAVTLTRCTLVGGVTALVADSVATRDAPVVVLVTLAVVAWLMDGIDGQVARRTGTTTKLGGRFDGEVDSILALVLSVYVAHALGLWIVVAIGAYRYLYLAAGLAFPWLRGDLPRRQSRSVIAAVQGIVLIVAAAGVVPDSVMTTIASVSLAVLTFSFGRDILFLYRRHTAVTRVVRTGTVSEPYVEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSZ6</accession>
    <name>A0A010ZSZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter,sugar transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851250.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2886"/>
    <dbReference type="HOGENOM" id="CLU_001265_39_5_11"/>
    <dbReference type="OrthoDB" id="446363at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="46119" checksum="C34F5A0AC5A48A30" modified="2014-06-11" version="1">MSETPIAQPRKAALAAWIGSALEYYDFFIYGTAAALVFNKVFFPDSDPATGTLLALATFGVGYAARPIGAFILGHIGDKFGRKRVLVFTLMLMGVSTFLVGCLPTYAQVGVLAPTLLVVLRLAQGFSAAGEQASANSMTLEHAPEGRRGFFTSFTLNGTQMGQILATAAFLPVAALPESALLSWGWRIPFLLSVLVMLVGYLIRRRMEETPAFVQEDSAKMPLAILFRDHWASVLRVILVAMVASVSTIFGVYALSFGTDTAGLERSTLLWVGVLANVVALGAIPLWASLADRIGRKPVMIGGTLGSAALMFAYLSAIGHGNWVLIFAIGILLSGVVYSAPNSTWPAFYGEMFTTRVRLSGMAIGTQIGFAIGGFAPTIGAAVSGDGRSGWLPVAVMLAVLCVISAVATATARETAHVPTADLGRTAHPSPTQIPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT34</accession>
    <name>A0A010ZT34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861130.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082109_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="27398" checksum="F1045609C76D0E8B" modified="2014-06-11" version="1">MIPVLLAAGSALVYGVGDYCGGTAGKRAPAVAVTVVAKVSAFPLLLVLTLLLGADAAPGAADLGWAALAGLAGVGAVVLFYRAMSAGAMAVVAPVTAAASAVLPVIVGILVDGSPGTVPLIGVGCAVVAIALVSAGGGRPAHVTPPLVGLAVVAGIGFGLFFVLLDRVHSGVGQWPLVVAQVAAILALVVLSSARRERMSVPRAALPFALAAGAFDTVANVLYVLANNSGQLALVAPLASLYPASTVVLALVLDREKVRGWQLLGLGLAGTALALLAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT74</accession>
    <name>A0A010ZT74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851366.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2979"/>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_11"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="22895" checksum="60485D78521FF6D8" modified="2014-06-11" version="1">MRLILIRHGQTPSNVAHLLDTGVPGPGLTELGLDQAAALPGALADENIEVLFVSTLVRTHLTAAPLASARGLEPVVRDGLREVVAGDLEMLSDHESVKTYLETVFGWSAGRTELRMPGGEDGTEFLGRYDAVIDEAAATGAGTVALVSHGAAIRAWVAARAANVDVEWAAEHALSNTGIVTLEGAPSDGWKVVTWEGQAVDLPEEPEDSGPTGQPLHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT90</accession>
    <name>A0A010ZT90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3003"/>
    <dbReference type="HOGENOM" id="CLU_103526_1_0_11"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="162" mass="17863" checksum="D9F003386C82BA36" modified="2014-06-11" version="1">MITVLHVTETPTLFDWAGGSAAFERLINAFYDRVEGDELLTPLFPGGVSDEHRTHVTAWWSEVFGGPAEYSSELGGYHRMVNKHVDLGITPEQRYRFASLMSLAADDAGLPDDPEFRAAFVGYVEWGTRIALANSQPGADIVQQAPVPRWGWGVAPPYQPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTJ2</accession>
    <name>A0A010ZTJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458272" evidence="2">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="470" mass="49339" checksum="417D0002167730F8" modified="2014-06-11" version="1">MRLLLLVLVLLVVGAGPAAAAASDPTDDYMRRYQSEHRLPGLAFAVVRGDEVVHSRTWGTDGDGDAVTADTPFLLGSVSKPFTALAVMQLVESGRVDLDAPVRTYLPEFPAGISVRQLLTHTSGLAQWALRTDRFGSDADELGRAVRELEPGHAPGEHEYSDANYLAAAAVVEAVTGRSFGDHLHTAVLDPLAMDHAVATTADAVSLPAGHRLYFGHPRRFDPAYDPSGVAYGYLGADLGDVTHFVTAQLRGGRYGSTQLLSPAGIALTQKGVADFGAGRYGLGWRESELDGDRIAWHAGATPGYFSHVVLVPGSDLGVVVLANAYSPTVDGELAAAAFDLARIAAGATPTGSDPDPLFAAATIAPLVVAFVLVVLLAWSLRPHRPRRRSVVRLIAWLLPCGALVAIAAWGFPAAMGVDLSQTRLWTPDIGLALVAVIVLAGALAVARVVRFGIPARPDNARPTADVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU00</accession>
    <name>A0A010ZU00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1737"/>
    <dbReference type="HOGENOM" id="CLU_051661_2_0_11"/>
    <dbReference type="OrthoDB" id="2055578at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="19869" checksum="8F99D828292539BE" modified="2014-06-11" version="1">MVTDLRPATDILAGLVRDVRDDQLGERTPSGGIPIAELLVHLDSLAGAFTDAATKTGLGTSGPPPAPDSSQLGDDWRDRIPARLVALGDAWAAPEAWTGATRAGGLDLPGDQAGAVALNEVLVHGWDLAVALGRRYPGDDPALADAVGSAYAWVSATVEGSPDGIPGLFGPRVRVAADAPPFDQLVAATGRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU02</accession>
    <name>A0A010ZU02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851795.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3281"/>
    <dbReference type="HOGENOM" id="CLU_072997_0_0_11"/>
    <dbReference type="OrthoDB" id="1626415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="32679" checksum="E920205E4581A2C6" modified="2014-06-11" version="1">MVEVVGTQESVSHRARRTWLRIFVVGAGLWVATVVVTFLTGNPNLIPTLVLLGSFLVPVTFVAWAFERRGTGELTSSLVFSTFLTGGVLGVLGASVLEAYLLHPSAWLFFGVGLIEEAVKLGALVVLTRHLRTRSLRDGMILGAAVGFGFAAFESAGYAFTALFTVDGLSIDQLVQTELLRGLLAPVGHGLWTAILGGVLFATMRHGRAIVSGRLILAYLGVAALHGLWDSMHSIALYLTLLLTDGERLRPSPQGWLIEPSVEQVNLFSGLEWAGLALISIIGIVWLAVLWRRSARGASVIPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUI1</accession>
    <name>A0A010ZUI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849962.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071040_1_0_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="28134" checksum="C644B27CE280E249" modified="2014-06-11" version="1">MAENPYVRLFLAQIRGQTQYRLSFAVDLVLNAGITTIDVLVLLTVFRVTPTLAGFGIGAVLLMTGLAQLAFQLADVAVGNLERVPQYLRTGLLDAVLLRPLSTFGQLIVLDFSIRRAGRIVQGLATYGIALRVAGIEWTPARVLLAVVAPLAGAVCYAAIFTAGAASMFWLVDGGEVVNAVTYGGRDFASYPTAMYGAWFGKLFGFGLGLASVGYLPALALLGRPDPLGTPAWSHWATPAVSVLWALAAAGIWRVGVRRYQSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUP0</accession>
    <name>A0A010ZUP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850055.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1982"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_2_11"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="42033" checksum="9E78E4360E159D93" modified="2014-06-11" version="1">MSRQSRDVVFVDGVRTPFGKAGPKGIYAETRADDLVIRTIRELLRRNPSLPPARIDEVAIAATTQTGDQGLTIGRTAALLAGLPKSVPGFAVDRMCAGAMTAATSVAGGIAFGAYDVAIAGGVEHMGRHPMGEGVDPNPRFLSERIVDPSALVMGQTAENLHDRFPHLTRERADAFALASQQKYAKALANGKIQRDLVTVATRSAEKGWGLATADEPPRPETTLEGLAGLKTPFRPHGRVTAGNAAGLNDGATASILAAEDVARELGLPIGARLVSFAFVGVEPEVMGVGPVPATEKALAKAGLGIDDIGLFELNEAFAVQVLALLDHFGIADDDERVNPWGGAIAIGHPLASSGVRLFTQLSRHFAERPDVRYGLTAMCIGIGMGGAVIWENPNWEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV32</accession>
    <name>A0A010ZV32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852420.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124855_1_0_11"/>
    <dbReference type="OrthoDB" id="2006762at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="47"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="18005" checksum="11B17ED3A70DD52C" modified="2014-06-11" version="1">MAILSVIVAVLTALVLVDLVLSAAIIRRLRETEAALIDLRTPPDTGLPVGATIPDFSTGDDGLSRDDLAGGPALVAFFSTGCSHCPAQAARLASRADELTGDGTRVVSVLTVSEGRADNLSPVLEKTGTLVTESDPGYLTAVFGETATPSFLLFDADGRLTRRGHELSDVLGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV77</accession>
    <name>A0A010ZV77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein, terpene synthase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852517.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A010ZV77"/>
    <dbReference type="HOGENOM" id="CLU_943086_0_0_11"/>
    <dbReference type="OrthoDB" id="1884685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="33406" checksum="692FD865F1844FAD" modified="2014-06-11" version="1">MTATTSPNPAATTGSARTAVRVVRLLRALRRWAAEVGPSFADAVEIDEVSAMVLVDAGPHAPTGELLAPAMTAVWMQVADDHVDRFTHDQAEFDGLIQRWRSVSAGARPTPGDPLERGLADLVRRLRTAPRYPSLFPVWRRSFGRMLDAWVFEQTTATRLARGEPAPSIESYLAHHHSFGLRPIVLAWWVTAGGDDLPDALEALLAALDEIETAVRLANDLVMADRARTEPGSVDALLLGADATWVSDRATEHLRRGHDLLAPLIETGSPTGEALGRIGEWLVTFYLLTDARLQGGGPGRRAAPAPIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVK6</accession>
    <name>A0A010ZVK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850489.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2310"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_11"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="4">
        <location>
            <begin position="74"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="32812" checksum="FCC63871AEC5236C" modified="2014-06-11" version="1">MPLHPQVQDHLDRLAGIGFAGLHTVTPEQARAGARRLASTLPAEPVADVSDRVTADGTPVRIYRPAGPGPLPVVVFFHGGGYVLGDLDSHDGLARALTTGSGCVVVSVDYPLAPEHRFPAAIEAGFAATRWVATNARELDVDPARLAVAGDSAGGNLAAVVTLKARGVLPIAFQLLIYPDLDFRRTNYSITRFAGKYGNVSREAQSWFMDHYLRGEEDKLDPLVSPVLEEDLRGLPPAFILTAEYDALRDEGELYGERLAAAGVPVRVSRYDGMIHEFLRHPFDDSAAALAEVSAAVRAGLSGAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVT4</accession>
    <name>A0A010ZVT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3941"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24624" checksum="1E2C0C29D5E7AB20" modified="2014-06-11" version="1">MLERAPLLADSVVTEVRDRIRTHRLVPGHTYSVYQLADELGVSRSPVREGLVKLAEAGVVRFRRNRGFQVLLPEPRDIAEIFAVRVALEVPAARRAATRGSDDALTAIAECMSELERTTDPAPFWERDRALHRLILLASGNRRAAATVDELRAITSLLDAPTDRTRAAVCAEHRPIVDALVARDAGAAAAAMRAHLSSTALLLMARAAPGDPAITTVWADLSAEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVV2</accession>
    <name>A0A010ZVV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852733.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3963"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_1_11"/>
    <dbReference type="OrthoDB" id="1840839at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="338" mass="35856" checksum="E08F4C0C63BE8B44" modified="2014-06-11" version="1">MTTPVRFGLVGYGFGGRYFHAPLLRAAPECELVAVLTSAPERRALVEREVPGAATVASLAELAGLGVEAVAISTPADTHSALTEEALGLGMAVVCDKPFALDASAARASVELAARLGLVLSPYQNRREDSDFRTVRALVDEGVLGTVTRLESRFERYAPQDGPGRSGGGTLLDFGSHLVDQALFLLGPVRAVYAEWRERESGLDDDVFLALTHESGARSHLWGSWSQSAPGPRWRVTGTEGTYVVAAGDSQEEQLVAGADTWGTEPEENYGTVYAGGSARRHPTERGRWDTFYPRFAAAVRGEGSPPVHPADAIATAVVLDAARTSAGTGAIVEVKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWR6</accession>
    <name>A0A010ZWR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2748"/>
    <dbReference type="HOGENOM" id="CLU_038034_1_1_11"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458099" evidence="1">
        <location>
            <begin position="25"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="35661" checksum="DB6A6ABE0E07634B" modified="2014-06-11" version="1">MKRLRILAQATLALALAVAVVGCGSDDDSGSSEPTASAASGAFPVTIAHKYGSTTITSAPKRVVTLGLSDQDAVIALGTVPVGAVDWFGEKPFGNWPWVKDKWNPAPTIVGERDEYQVEKIVGLKPDLIIAQYSGMTQEQYTTLSKIAPVVAQIKEFPDYSAPWQDMAKVIGKSLGKEAEMDAILGDIDAKLAQVKKDNPGWANQTAVVVDPSEPGMYAAFAESDPKAQLLRDMGFKLSPEVTEIAGKDTAAVLSAERLDVLDVDRLVLLATDNTVQPRVEKDPAFAALKVAKEKRTTWLQYTDEPPIGGALTFVTPLSVPWAVDQLVKQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXF9</accession>
    <name>A0A010ZXF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="42" mass="5377" checksum="DAF94F31E914E79D" modified="2014-06-11" version="1">MSDCYGWDYNQGNDWDYNECKPRRRRHHKKRYNDCWDYNPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYK4</accession>
    <name>A0A010ZYK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase and lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851939.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3372"/>
    <dbReference type="HOGENOM" id="CLU_136825_0_0_11"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="165" mass="18241" checksum="E369EC5375A23C23" modified="2014-06-11" version="1">MLIARTDKTVPITVFARTSAAPDVAFRIVAPIDLSRVFLADRLFPGVAGVEGQTDTWDHAGVSRRPRFTDGSQVTESLTEYVDGHGFAYELTGFTNTLATLALGVRGEFSFLPDGGGTTIRWTYEFKPRPGRRLVLAGPFKPLWQRYMQAALNRMVAVVEEHTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYN7</accession>
    <name>A0A010ZYN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851999.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3436"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_2_11"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="555" mass="58513" checksum="26BB99A304DCFA5F" modified="2014-06-11" version="1">MDVDLLVVGSGAGGLAAALVGADDGLSTLVVEKTEWLGGTTAYSAGTAWIPGHRYTADAAADVAAARGYLDALVGDRAPGELREAYLAHGPETIDHLARLGISFRHSASVVDYHPEVSGWGVGRALEPVPFDGRRLGVERFRRVRRPVPEFALFGGTLMIRRAEADQLLRLFDGSPRAAALAARLGARWALDRLRYPRGTRLTMGNGLVAALYHQLVRRSGAVLFGAPATELITNGGRVVGAVVEHDGRTRRVAVRRGVVLAGGGFAASRELRATYLPRPVAAHTRASDGATGDSLALARSVGGAVSSGVDDNAFWFPASIGRRRDGSEAVFPHIWDRAKPGIVAVDSAGRRFVDESVSYHRFVRAMYARSAIPAWLVLDARTLARYGLGMVRPHAPGASRRHHLRTGYLRGGATVRDLAAAIDVDPAGLERTVAAANAAASRGVDDEFGKGTSPYGRQYGDAVHRPNPNLGPIDEPPFYAIAVVPTPLATALGLRIGTEAQVLDHTGEPIRGLYACGNDAQSVTASEYPGAGCQVGAALTFGHLAARHAAANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYU5</accession>
    <name>A0A010ZYU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570486.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3519"/>
    <dbReference type="HOGENOM" id="CLU_004665_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="624" mass="67829" checksum="DA99A56070F2FF2D" modified="2014-06-11" version="1">MEIHNGDEWRLVAGAKVRALLAVLVVQLGQLVPLDRLVAEIWGDGPPASADSLVRGYVLTLRRTFGADGASCVVGHGRGYRLDLPPEAVDVHRFDAICVAGHQALQRGDAEDASLLLTDALALYRGPALVDVPPTRTGAAYAAALEERRLVALEARIEADLRAHRQSAVLGELRALVAEHPTRERLAGQWMRALAATGRRAEALDAYRVTYDRLVDRFGIVPGPQLRAVHRDVLAAEHVDQTMSPAPRARRPDGADRWTAPAQTPADLADFVGREAELRFGRQALDAADPTTVRVLAISGPPGVGKSALAVRLAHDLRRAYPDGQLYADLDGGPGRIADLRGVLAGFLRASGVPDSVIPNGADECAALLRSRVADRRVLLLVQNAHREQDVRTLIPGGAGCAVVVTSRTCLSGLAGCRLVDLDVFTFDEAWRLLERAVGTARLEAERHAARRLIELCGRLPLAVRIVAARAAATPETSLTWLLAKMGEERRRLDELHLRDLDVRAAIRKGWVLLDDRARLMLQRLAMLEVVSFPGWVADVVSGFDEASAEEALRALVDQRLLATAGVDRYGRPWYRVHTLTRLFAKEHATPVLCTPPRRTAPRARPAFLRPPVVGTAAVGRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZQ4</accession>
    <name>A0A010ZZQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570639.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3876"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="41362" checksum="53EC01E58B26FBDF" modified="2014-06-11" version="1">MSLDRYRGPLSDVVMTVAGVLTVLFVGYHSVRPATMALSVVCALPLLARRRYPVPALLAAIVIGVSVIAVGRPPDGFFVVAGMFTYSAAVWSAHRRPWSYALLVWGSMMVAGSVVYTTDWWTTDQLTTFSFVFGGAAIGDSIRMRRAYVAEVTERARQAELNREEEARRRVIDERLRIARELHDVVAHHITVISVHAGAAGHALRDEPDRVWPVLEHIRTAADTVLEEIKSVVSVLRDPDEISSTEPAPGLDRLPELLAGLRTAGLGVRFHEHGTARPLPAIVSLAAYRIVQEALTNAHRHGEGEATLEVGYRADTVSIEVTSRMARPDERRSGSGLGLIGMRERAEAADGTITIGPLADGRYRVRAELPAGRVLEGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAS9</accession>
    <name>A0A011AAS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sortase-like acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569550.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099459_1_0_11"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="21061" checksum="4FAB86B500C5B571" modified="2014-06-11" version="1">MIPSALDLHALDTDEARAIQDELFGLYARIYADQLSDPFYSEERFAERFAGHSGRPGFELVTGRVAGELIGYAYGGPLPPRTQWWNGLREPVPAEQLDEDGARTFALNEIMVTQDWRRRGIARTLHDALLAERPERRATLLVDPGNTPARTAYLSWGWQLLGHLQPFPDAPVYDALIVDLPLRHVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABB7</accession>
    <name>A0A011ABB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890579_0_0_11"/>
    <dbReference type="OrthoDB" id="2189427at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="33085" checksum="D0D9D1144B6FA543" modified="2014-06-11" version="1">MPGDYAAASVEGSTTVNSQDEPRRTMAPPWSAVTDHQRPTTQHLGHATWHGPAFQSGGPSWPPPDVDDVPAPHPPTYDTSAAPPPIYGGAPAFLPNHPTAEPPEHHVTEPIPTYRPTARGTARPSRHNGSPMTLGDVLTILGGVLVLAFSMLPFVSYTDERFVAVENRADLATSWTAWSPSTFLAPLSWVAIVAAVLVTVLGVLRVLERGHRTMVGVTVEQARVLLAGLGFLILFSFAVSSKTVLFGDDRPQLTAAGVIVDSTLSLDSGGYLMLLAAAVQLAGAVWIARGAGGPAVWPLPDSVRTMFAKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC92</accession>
    <name>A0A011AC92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848440.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.690"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="21340" checksum="4A8A01259A4BE85A" modified="2014-06-11" version="1">MSEEIRLLLADDQALVRGALAALLDLEPDLTVVAEVGRGDEVAAAAAANRPDVALLDVEMPGLDGIAAAKAVRDALPTCKVLIVTTFGRPGYLRRAMEAGASGFVVKDTPAKQLADAVRRVHAGLRVVDPTLAAETLATGATPLTDRETDVLRAARAGGTVADLAKELHLSEGTVRNHLSAAIGKTGARTRAEAVRLAEANGWLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACI5</accession>
    <name>A0A011ACI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848513.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127487_1_1_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14561" checksum="F56DF79296860B34" modified="2014-06-11" version="1">MDTLHRALAALDHHECLALLASVPVGQVVFNARALPEILPVNFRVDGDSVVLSVASGSVLARVSDGTVLAFHADRVDETSRTGWSVTVVGRVSEVTDEAERARIRALPLQSWTSDERDHVLRISAERVTGRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACN8</accession>
    <name>A0A011ACN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848579.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.831"/>
    <dbReference type="HOGENOM" id="CLU_037315_0_1_11"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="245" mass="26369" checksum="1ADD77FF0CE827CE" modified="2014-06-11" version="1">MTGSLEFHSPLSPERARRIVDRLAGGHPATVLDLGSGWGALLLRLLDAIPGATGVGIEINTDDVARGRDLARRRGLADRVEFVEESAVGTERGPADLVLCVGSGHALTETPGDFAGTLRELRRLVAPGGRVLYAEGFWQRTPTDAELARMWPGATGADHTDLAGLVEIAVGAGFRPVWTETATEDEWEQFESGYQADLEEWLAAHPTHPDAAARRQKADSHRASWLGGYRNVLGMAYLTLAPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACY6</accession>
    <name>A0A011ACY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.952"/>
    <dbReference type="HOGENOM" id="CLU_291302_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459545" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="707"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1048" mass="107524" checksum="BAD2F86E4517A8D9" modified="2014-06-11" version="1">MGAHARRASHWRAPAAAAVVGTVAAMLASPPASAVNLVGDTGYGNLKGAALAGWSDTLGISAVQLASGKRLVLSQAPASTPGGTPGAISLTQFKADGTLDTWGTGSSGRVDLTNNGTTTAGVTVSELLVNTTDNSIWVVGKKASDIVTWHLDATGLALAGGSVLTGNVATTGIAAGYAPGFFIVDAALDSNGKLAVAVQASSTTLSPTNYARVYKLLATGALDTANFNTTSGYVDVPAAAGRKVLSLGGIGYGASDVLFGTAQVSGATASDDTESSVYRIASTGVADTTFGNTTNSSGSGESIAIEAYAEAQSPKWQNESLSDVIAVDSNANLLVSGKAGNGYFLAKINTATGQGDLQGAFGNDGVTSIAASPAGAGDPEIAVGGSPTRYWLANDAADGTAEVFRWTLSGGMDPAFGNNGYQRLQSSDFGHLGSVTAEPITFSATSTTTAPINTPIVGAGTNRQVTGGYRYDAAGWKLVAPSAPPVITAPTISSDNAATPIASTGVDVGDTQQFSVTFTSNVTPTIEWQWAAPGSTNWQPVQNGGIYNIATTYTPTSTYATTLKIFTSSTAQNGTQFRAVATNSAGTKVSAVGTLPIKGYPVITTQPAGDSVFVGATNVKFSAGFTVPGGSAVTSARWQVLKVGHNDWEDASGTNYVTSSPVATSPSVLTVAKVDSSLNGAKFRAIIGTATGSVASNVATLQITGAPVISHQPENTSVEEGKEATFWVQASGSSALTYQWQWSKSGADDSFAAVPGGTSPTLKWPNAKLSDSGTYFQVKVTDANGNFEYSLKAKLTVTAKGAVHAPAWGDYDGDGKTDIASFKDGSFYWNGAEKPETFGQAGDKLIVGNFDSDKAADKAVVRGNTWKTDGNPDVSFGKSTDWPVSGDFDGDGMTDVAVWRPSNGTWYVKGGMTVEYGKAGDIPVPADYDGDGSDEIGVWRPSNGTWYVLGMKAMSWGKAGDIPVRGDWNGDGSGDMAVYRPSTSTWYPMGAKSVQYGRAGDVPLAGDFNGDGNSDIAVYRPSNTTWYFTTMDAVKFGGSGWWPVTGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADQ9</accession>
    <name>A0A011ADQ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureC</name>
        <name evidence="13" type="ORF">CryarDRAFT_1257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848991.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1238"/>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_11"/>
    <dbReference type="OrthoDB" id="157757at2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="136"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="573" mass="60524" checksum="CE04BB642B6C05B6" modified="2014-06-11" version="1">MTDSIDRSRYALLYGPTTGDRVRLADTALLVEVEQDLSRGPSAGEEVVFGGGKTIRESMGQSRATRADGAPDLVITGALILDHWGVVKADIGVRDGRIVGIGKAGNPDTQDGVDENLVIGPSTEILAGNGKILTAGGIDSHVHLIAPQQIEEALGSGITTWIGGGTGPAEGTKATTVTASAWYLARMLEALDDYPINVALLGKGNTMSAESMVEQLKAGASGFKLHEDWGSTPSAIDACLRVCDEYGVQAALHTDTLNEAGFVEDTLAAIAGRGIHTYHTEGAGGGHAPDIITVASHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPAVPEDLAFAESRIRPSTMAAEDVLHDLGAISMIGSDSQAMGRVGEVVLRTWQTAHAMKVRRGALPGDGAADNARAKRYVAKYTIVPAIAHGLEAEVGSVEVGKLADLVLWDPKFFGVRPHVVVKGGVIAWAQMGDANASIPTPQPIFPRPMWGARPTVASATSVHFVAPVALEDGLADRLAVRRRLAAVADVRRRGKADLPLNDATPEIRVNPDTFAVYVNGELIEEAPAAELPMAQRYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEN6</accession>
    <name>A0A011AEN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin biosynthesis docking scaffold, SagD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1552"/>
    <dbReference type="HOGENOM" id="CLU_020793_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="60"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="451" mass="49854" checksum="EE400785C54C38F5" modified="2014-06-11" version="1">MTLDAPTPAEALLVDPRFGLLTAVRPDPYPEMPAAWVGYGAAVADTRQFTDWHADPFGFGAAVGDPDRARRAAIGEAVERYCGRVVPPDLFRGSWRQWGENALDPETFALYSDRQYATPGFPFVPFGRDTEAEWVEGRDLRDHSPVLVPATSVYLDYRPPGRRPLHALSYAGIAAGTDREHAERFALEELFERDATTIWWASGAPAELVADGYRVVDLLDDRHADRRRVRLLRVPSPFGVPVLCAFIEDADRGLVAFGSACRADPVEAGLKALVEALGLLQMTAQLADPDSELWSARQRGTILPHTFVAFRADRRYSESFRADYRDLVDLPALAQLYLDPRMQGSPLERLRPESPRIALADIPRIADPYESYLAKLTDAGHRIVSVDVTTPDVRAAGLCVVRVVVPGLYGNAPAAFPYLGGRRLYEVPVDAGWIDRPLTEDTLVRDPLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AES0</accession>
    <name>A0A011AES0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849472.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="30506" checksum="495F3FD8278F0E92" modified="2014-06-11" version="1">MDSWEFGRTVRRRRDRVAPGDVGLRATGRRRASGLRREELAGLAGISADYLTRLEQGRATSPSAQVVEALARALRVSDAERALLYELAGHASPGRDLVPSRLAPSVQRLLDRLSTTPVVVYDATWTLVVANAPYEALMGDTSSWRGIERNAVWRHLAGSGNRTVHTAEEEADVQAGLIADLRLTFARYPADRALARLVEDLGALSPRFVELWESGSSNAGREPTRQKVIDHPAVGEITLDCDTLVVATDELRIMVYTAEPGTSDAERLDLAIVLGTQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEY4</accession>
    <name>A0A011AEY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849555.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1646"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22597" checksum="CF5521C44A6C1C75" modified="2014-06-11" version="1">MIGVLLVDDEWMVRAMLRTILESAEDLTVVAEAADGAEAVVQARRHRPDVALVDIRMPGVDGLTAVRQLRGGPKVIVLTTFDLDEYVRTALRDGAVGFLLKDASADEMTTAVRAVAAGDAALSPRVTRRMLSTFARPSPQDRALARLAPLTGKEREVLATLATGLANADVARQLHLSEATVKTHVSRILTKLGLTNRVQAAILAHHAGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFJ8</accession>
    <name>A0A011AFJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1839"/>
    <dbReference type="HOGENOM" id="CLU_1616266_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458695" evidence="2">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="16412" checksum="3247941349BF2BEA" modified="2014-06-11" version="1">MAKHRAICPSLVTVASLLTLLLGAAVMAEVAVAAVPGVLIWQLAVAWVACSVALGLREGRSWALYATAILAVASPGLAIAAADVVGPVAAAPFLLAPAAVALLVPERSARWLRRRRPASAPTGRIMVSTPVTGSTTRTSAALAVQSDYALVGAVPAQGSAGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG09</accession>
    <name>A0A011AG09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthesis pathway, component FliQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850093.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2021"/>
    <dbReference type="HOGENOM" id="CLU_164516_2_0_11"/>
    <dbReference type="OrthoDB" id="1939288at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="9754" checksum="08FEB58C3BD16303" modified="2014-06-11" version="1">MTDAQIIEIGLYTMTIIAKLSAPILLTTLGVGFLISLFQSVTQIQEQTLSFVPKAIAAGAALLLGGNWMLHELVSYTTQIYARIPTLLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGD6</accession>
    <name>A0A011AGD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly(3-hydroxybutyrate) depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458529" evidence="2">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="28328" checksum="B3B74929ECF5038A" modified="2014-06-11" version="1">MRRLLPALLLLLVAGCSRPDPDVHTLGERTYRTHGSGGTAVIVLHGGGGNGAQIAEQTGFDALADREGFRAVYPDGSGRTDLRTWNAGSCCAYAHDQGVDDVGFIRALIAELDADRVFVTGFSNGAMLTYRLGCELADEITAIAPVSGSLGVPSCEPSRPLPVYVIHGDADQVVPYAGGKSAKRVAGSHPSVGYAVGVWTGVDRCTGAPVRSVSGVVVSDRYTSCASGTEVRLDTITGGGHAWPGGVPGRRGADQPADFDASAAIWAFFTTHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGF1</accession>
    <name>A0A011AGF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850270.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2159"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23025" checksum="F1D102DFC6C2F507" modified="2014-06-11" version="1">MISVLLVDDEALVRAGLRLILQTASDVTVVGDAEDGRAAIEAVRRHRPDVVLMDVRMPHLDGVAATAALKAEPHPPAVVVLTTFNTDDDVFRALAAGATGFLLKDTPPTDLLRAVRLAAAGDAMLSPSVTRQVITRFTGDDGSRRREALAELESLTGREREVLVEIGRGAANAEVAARLHMSEATVKSHVTHLFEKLAATNRVQLAIAAFRAGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHA8</accession>
    <name>A0A011AHA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2476"/>
    <dbReference type="HOGENOM" id="CLU_081297_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="10912" checksum="D58AB69347073929" modified="2014-06-11" version="1">MTYSPPPGQYPGGQPGGYPGGQPGYGAVDPATGLPYSDKSKLIAGLLGILLGSFGAGRFYTGHTGIAIGQIAATWLTCGLGALWPLIDGIMILVNGGTDAQGRPLRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHY6</accession>
    <name>A0A011AHY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAF family repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570133.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2706"/>
    <dbReference type="HOGENOM" id="CLU_054530_0_0_11"/>
    <dbReference type="OrthoDB" id="415763at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458404" evidence="1">
        <location>
            <begin position="23"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="37225" checksum="4C9E67E85EB3F882" modified="2014-06-11" version="1">MRSLLCGVVAAALLVPAGTASAADRAIVTVTRLPVPAGTTGSSAADVNDAGVVVGTADVRGVSQALRWAGGSFTRLPASATLPEARAARITDSGLVVGSIESADTTQRGIRYWAPGGATTDCALATGFPLGVTDVNDRGDALIWVGTGPRAFTYAVCHPDGTSTATNLLGAGGIDDTGRVAGFRNAGASTNFQYVPVVAADGTAADLPVPAGQSAVADDIAPDGTVVGSLGTSTWGSFGPVYTPRKAVAWIDGEIVELGGTSATGISRTGDVVGTLTTAGGSTHAFLWRAGRRTDLGTLGGDRSFPNAVNDRGQVVGTSTTASGATHGFRWSAGRLVDLGGPSGTAAAVNDAGVVVGSVTTTSGVTRAVRWTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIF1</accession>
    <name>A0A011AIF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851191.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126433_1_1_11"/>
    <dbReference type="OrthoDB" id="2025483at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="12179" checksum="16670D6BD9094FBA" modified="2014-06-11" version="1">MSVAYVTVTVLTALINGTAAITYLIGHDYPKAMVTMKRLPLGWMPLLGSLLAAGAVGLLVGFAVPWIGTLAAAGLVLYFAGALVAHLRVGSRKLTGWAVFTALAVASLVLRVPGGGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK69</accession>
    <name>A0A011AK69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852100.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3502"/>
    <dbReference type="HOGENOM" id="CLU_025711_4_5_11"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23797" checksum="4A4216AE08BB1C4C" modified="2014-06-11" version="1">MSPQKTFLVFGATGQTGKHFTSIALDDGHRVRALVRNPRKLATDSPNLEIHQGSITDDLDLDRLADGVDAVICLLGDKELQKSQKINTPFVRNLVPALRRAGVARFVYQAGGLSAPPGRRLPLYLRAVRNSIARGYIGQHEDNEAVMRYLADEAMDIEWIVHRAGIGSDGPSKGVLERSAKAISIATFVDCASYTYRLVTDPTAVHTCDPSAYRKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKQ4</accession>
    <name>A0A011AKQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3713"/>
    <dbReference type="HOGENOM" id="CLU_028723_10_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="2">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="17304" checksum="091DE6B29208456D" modified="2014-06-11" version="1">MREEVEPLWTTKSAVRAVLPTALAATLGVLVGGTLVARRRLLVIDVVGDSMSPVYDHGDRLLVRRTRRFRVGDVVIAHHQVGGRRTLPPGSLATSWLVKTLAALPGDAVPPSVAAAVGSDRLIVPPGSVVLLGAHPASADSRLWGLVPAEDLAGVVITRLGSAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKY3</accession>
    <name>A0A011AKY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570611.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_11"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="464" mass="50956" checksum="FAFDEF513158591F" modified="2014-06-11" version="1">MSLQHGVASADRGTPPAVPGALPLLGHVVPLLRRPLEFMDELRRHGPVVRLGLGRVPVYVVTDAQLTYSMLTAESGSFHKGGRLIEALSRFAGNGLATVPDGDRHRRQRRLMQPMFSRSFIAGRAGVMIETARSVVGGWAPGEPRRTDDDMQELTLSVFLSALLGAQPPTEVRREFQRVLPDVMAGTIRATILPRALGAIPTPTQRRYQASLRDLRTAIGALIDAHGARSNDGGPADPDRAGLLDLLLDAADPESGQRMSRTQLEDEVITFVTTNGQASTASILWALYEVGRDPDVERKVHAELDAVCGQRPLRAEDLKSLTYLRRIIHETMRLYGPAWLLTRKVSAPGVLGDFVLPAGADVVFSPYVIHRDPVVYPDPARFDPGRWSPERAASIPRTAFLPFGAGTRQCIGDNFAWDEMTIILAETFRQWRMTPTGDRAPKPVPRVTIHPDRLVMTPEPVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL44</accession>
    <name>A0A011AL44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852609.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097446_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041485">
        <property type="entry name" value="TetR_C_36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18598">
        <property type="entry name" value="TetR_C_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_36" evidence="1">
        <location>
            <begin position="73"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="20905" checksum="5FB1C9D3389910DF" modified="2014-06-11" version="1">MSARPTATDAFRLARRTFLAGERVDLKRLAAELDVDRSTLFRWLGNRDQLLVDILISLSDPTLRTIVRDAEGTGGRRVARIAGAYAAALIDASYYREFMRREPERALRLITTKASPVQRRVVDEFARLLAHESTRGELRHPLGTNDLAYLIVRIIESFIYADLITGEEPEAAKVETAVAAILRADGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALA9</accession>
    <name>A0A011ALA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852653.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3890"/>
    <dbReference type="HOGENOM" id="CLU_181321_0_1_11"/>
    <dbReference type="OrthoDB" id="2067093at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="7185" checksum="C4701B4047ABB4CA" modified="2014-06-11" version="1">MSNQRQYEVVLNLEEQYSIWPTDYDRPAGWRAEGTVGTRQECLDHIDGVWTDMRPLSVRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALI5</accession>
    <name>A0A011ALI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylamine utilization protein MauE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101331_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459517" evidence="2">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="18414" checksum="59F058B83BB5540B" modified="2014-06-11" version="1">MRVAVVGLMAALVVVFGVSAFGKARSRAALRGFTASLRGWRVVPGPLVAPVAVVVVGLEVTIVAGALVSLVVPGAAGRVCAAVTSGLAAVLLAALSVGIALALRRGPGATCACFGATERPLTPGHLVRDVVLATACAAGVALALAAGDAPAEPAGVAVAVFAGAVAGLLVARLDDLIDLFSPRPAGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM03</accession>
    <name>A0A011AM03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570717.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4172"/>
    <dbReference type="HOGENOM" id="CLU_010524_0_0_11"/>
    <dbReference type="OrthoDB" id="809897at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113164" checksum="192A705A0388BB4B" modified="2014-06-11" version="1">MSRSLSYADAVRILGGSHSKTVTVLERATGGLLLAATAGGSGLAMSLFDAKAELAQASHLLVSDLSDRAAGLSRIDRTQRLAAGHAALVVGAYFDALSSIRLPISGSALEISGVERVTLATGERPRSARLGDLGRALLHSDVPIPMPHVPPEVLLADVERFYDRMSDAVAEFLAGLAAWDSLRDADRERIFEALHGHVIDRAVAGYQASFRRMAGEVPEFGFWVNLLDHQATRDRITTVTIGVAALQEMLASLAPDRIGRRTRTSLSRAYAAALHDPLLDTQGNDSGPAIPNIASSYVNPSFRVAAVGPQDPIADERWWEGQSTHDDLMRFLIGHLTSVSAVNGPLLLLGQPGSGKSLLTRMLAATLPAEDFMVVRVPLRDVPADASLQLQIEQAIFDTTGERATWPEVVDVVPGALPVVLLDGFDELLQATGVSQWDYLMNVARFQRRESVEGRPVAVIVTQRTTVADRARPTADTVALRLEPFTDEQIVEWVALLLMLAIYDAQDNALQARLGAELKRADLYERLLGQFARREVLKAGQGHPDDHVDGLMQEELFRLAMVAFAAFNRGRQWVAETDLNADLPILLDSESSHPAEATSARQGLTAGQTVLGRFFFIHEARARREEQPLRTYEFLHATFGEYLIARALDRELDDLVEDAVRQARRSRMTRIDDDFLYALLSFAVISQRRTTLDFLTERLGAWEPRRRASIRTILVGLFHRSMEARDHGRLTDYEPVALTVPARHATYSANLLLVLIATGERITTDDLFPDTDDRIDAWRRTAQLWRSQLRGDAWSRLVGTLGVERQWNGEQRSLRFFRDLSWPEADAPAADLWWTRDVLTADKQYPEFERGTFSWLTENDALRQWQTNFLCDPLDDLAHHALESLAAKIADSVTSVHGYWDDRAVSAARSLIDLWLRTSTPCAQEDVFTAFSDCFEIARRGFPPSGIEARRTYRTIVLRTLRAHRERLNRAQVAALRSVFETPEPGTDEPDDLARLTIEILGDGEEAAEQANDPKERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGC7</accession>
    <name>A0A010YGC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847816.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087941_0_0_11"/>
    <dbReference type="OrthoDB" id="1538944at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14213" checksum="6E97944E83E6FBAE" modified="2014-06-11" version="1">MPASAAPRPLPMTAGALIVGGTVHSHTSMRGDVAPNLHPLVSRMLDELPAEKRERYAGWCAEVALISDRLHDAEEKAGRPITVADAREALQGGQIHISRIREDGDPTHGRFQPPCRSCTVLLEEFGITTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGT2</accession>
    <name>A0A010YGT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MccF-like protein (Microcin C7 resistance)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848169.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.506"/>
    <dbReference type="HOGENOM" id="CLU_034346_1_1_11"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="201"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="35320" checksum="09F9F1A200A1B475" modified="2014-06-11" version="1">MTTLPRKLTAGDQLRVIAPSSSLQLISDANRDAAIDRLTAEFGVRVTFSEHVNETGPLGTGPVAGRVADLHEAFADPDVSGILTVIGGYHVNQLLPHLDYDLIRANPKVLCGFSDITALQCALLARANLVTYSGPHFSTFGMREHNEATIEAFRSAVFGEAPVGWVPAEVWTDDEWYRLTEREAPERNEGWWVLQPGTANGPLVGGNLGTINLLQGTPYWPDLDGAIVVVEDDFESTVHDFARHLTSLLQTGIAVRGLVVGRFQRRTGMTRDVLRHLVTTAPQLAGVPVLANVDVGHTNPLYTFPVGGSCYLTADPGAVEIVLTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIA7</accession>
    <name>A0A010YIA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848759.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1036"/>
    <dbReference type="HOGENOM" id="CLU_013985_3_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="19865" checksum="38C22231F9D5A4E9" modified="2014-06-11" version="1">MDSVEIVAGSFQLRPCQTVDTEWICRACQDPDIQRWTRVPSPYRSNDAFAFVTDFVPRSWESGRAAPFGVFDAVSGEGLGTVSLVSMDLGDGLAEIGYWVAPWARRRGVATAGTVAVARWAFGTLGVARLSWMAEVGNHGSRAVAERAGFTVEGTLRDRIRRRDGSRADAWIGSLLPTDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIL1</accession>
    <name>A0A010YIL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1136"/>
    <dbReference type="HOGENOM" id="CLU_1737494_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008497">
        <property type="entry name" value="DUF779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05610">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16219" checksum="2FF5F51C90953989" modified="2014-06-11" version="1">MLASRPYRQALAAYRGPVLPRSDAPFVTAVREEARLRLRRALLRHAGVDVLLQYAETPEAGTADDIEKALDAAHAAAPARARRRSPTDVLLGVLEPSVPVWISAPQFAAWRHTQLALDVEARGLPAPAGPSLISDEDYAEVCVPTIGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ20</accession>
    <name>A0A010YJ20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849024.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1266"/>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="21403" checksum="195BEED18F4171F8" modified="2014-06-11" version="1">MDFARSDAPGGIEVPLALKILIAGGFGAGKTTMVGALSEIPTLSTEEVLSDVGIGIDDVSSTDRKETTTVAMDFGRITLQDDLVVYLFGTPGQDRFWFLWDELASGALGAVVLADTRRLTDCFPSIDYFERQGTPFIVAVNCFHNEQTHGVGDIAAALDLDPGVPVVLVDARDRRSSRDALVRLVQHVLRLTAPEAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJE6</accession>
    <name>A0A010YJE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1396"/>
    <dbReference type="HOGENOM" id="CLU_013645_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="JmjC_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="PTHR13096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="107"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="43548" checksum="DA94AE1573429C49" modified="2014-06-11" version="1">MTDSSLRTTGLPAGRPALERCISVPVADFPWGRRPLLSTGLGFGDLFGLDDVDELLTRRGLRTPFIRLAKGGEVIDPRRYTSSGGAGAEIADQVDDERVTRLFLDGATIVLQALHRTWPPLVDFGQQLAADLGHPVQINAYVTPPQNQGFSAHYDVHDVFVLQVAGEKQWRIHAPVLTDPLRNQPWNSRAASVAARASEEPVIDTVLRPGDALYLPRGWLHSATSLGETSVHLTVGVHPVTRHSLVEVLAGLAAEDPSLRESLPLGFDPTDPSLLAGAVDALSSWLRTVDADAVADRLRERVWPQGRSEPVSPLAQERIVSSLTADTPVRLRGFLPHTVDVRADGVVLRLPDRTLTLPAVTAAAMKTVLSGTVVRAAELPDLDADDGLVLIRRLLREALVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJZ8</accession>
    <name>A0A010YJZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3403071_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="30" mass="3213" checksum="172DB055A64AD392" modified="2014-06-11" version="1">MSEGGTAGRGGYAMAKKKKDKKKSGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKG9</accession>
    <name>A0A010YKG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1782"/>
    <dbReference type="HOGENOM" id="CLU_135445_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="13300" checksum="7EC4A763BF4A7FF2" modified="2014-06-11" version="1">MSDDRGRVSVFLAIALAGVLILIGMVADGGARLRAMQRADNVAAEAARAAGQGIDGGTAIPGGEKQLDPELAGQAAREYLAAAGVPGTAVVGEDGKSVTVEVTITRDTAMLSLIGINTIQVTGRATAVLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL82</accession>
    <name>A0A010YL82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (ATP-grasp superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850141.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2055"/>
    <dbReference type="HOGENOM" id="CLU_055821_0_0_11"/>
    <dbReference type="OrthoDB" id="605198at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="33385" checksum="914BDCA0A8B8C956" modified="2014-06-11" version="1">MPDPAELYEIVGDWEPPADSGLVLLHALDGFLDAGSAAQLAANHLVETLDGEIVARFDIDLLHDYRARRPPMVFVEDHYESYTPPQLVVHALKDSTGVPFLLLNGPEPDVMWERFTSAVGQIAERFGVRLVVGLGGVPMTVPHTRPTTLTAHGTRPELVRRTNVWRGNLRIPGSASALLELRLGERGQDAIGFVAHVPHYLASVEFPQASAALLDGVAEETGLLLPVGSLHQAGVTRLREIDAQLADDPQAVGVVKALEEQYDSFVSNRQQAELGGEMDDNVPSGEELGAELERFLAQLERGDDDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLI1</accession>
    <name>A0A010YLI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850249.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2146"/>
    <dbReference type="HOGENOM" id="CLU_102185_0_1_11"/>
    <dbReference type="OrthoDB" id="1571420at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="161" mass="18303" checksum="6AC746E97E7D91A8" modified="2014-06-11" version="1">MNLPARDLTKRELKELVDDLAGHPERWREHIAFSDTERHYVSLYRDDHVDVWLLCWTPQNDTGWHDHDISSGAVAVVQGAVHENNPRIGGEHVDVVVREGESFCFGPDHIHRMAGADPESVSIHAYSPPLWRLGTYLITDDGVMRRTSVSYADELRPLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM47</accession>
    <name>A0A010YM47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850526.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632189_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="77" mass="8475" checksum="A631813B3791ED03" modified="2014-06-11" version="1">MEHTERLAIVRLAATYHDTLGRVQTATQLDAVLRLGRELSTTLPADQAELFARLCRARDAATRGAAGRIPHPRKPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM96</accession>
    <name>A0A010YM96_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">CryarDRAFT_2446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850621.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2409"/>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_11"/>
    <dbReference type="OrthoDB" id="662268at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="370" mass="39319" checksum="89208035AF2807D2" modified="2014-06-11" version="1">MSTTSALLVLEDGRTFRGEAFGAIGETFGEAVFTTGMTGYQETLTDPSYHRQIVAMTAPHVGNTGVNGEDDESARIWVAGYVVRDPARISSNWRATGALGDRLADEGIVGIAGVDTRALTRHLRERGAMRAAVSSTGESPAEVLEKVLASPSMAGADLVGDVTTAEPYVVPAQGQVRYRVAAIDLGIKRNTPRRMAERGIEVHVLPATTAPEDLLRLAPDGVFFSNGPGDPATADGPVALARASLGADVPTFGICFGNQVLGRALGFGTYKLRYGHRGINQPVMDRQTGKVEVTAHNHGFAVDAPRDGAAETEFGRAEVSHVCLNDDVVEGLNCLDKPAFSVQYHPEAAAGPHDADYLFDRFVRLMEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMC0</accession>
    <name>A0A010YMC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metalloendopeptidase-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570067.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2439"/>
    <dbReference type="HOGENOM" id="CLU_037105_0_0_11"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="261"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="40486" checksum="5A00D85383D4CB5C" modified="2014-06-11" version="1">MAVDLRPDADETPPPEKSRLRKFVVIGIALAAVSALLCLGFTPMVFNSVVQSMRDSAENAQQGCGSLGFSVDDNVKIDGLAADQLQNAATVIGVGQKMKVPPRGWVIALATALQESLLHNYTVATDHDSVGLFQQRPSSGWGNAPANASDTRTPAQRLTDPAYSSAKFYEKLLRTPSWNSRRLADVAQAVQISAFPEAYARWEGFATLLVNRITKGAANGVVASQGDPIRCATPGQVSGAGWTVPALGHVGSGFRTADRPGHAGVDIIVPRYTVIHAASAGIVVTSTCNASTDNCDVDGSPAVKGCGWYVEIAHTTGLTTRYCHMVERPAVVVGQSVEAGQPLGKVGSSGNSSGPHLHFETRVNGDAVNPIAFMSARGAPLGESQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMD1</accession>
    <name>A0A010YMD1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850688.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2454"/>
    <dbReference type="HOGENOM" id="CLU_060471_3_0_11"/>
    <dbReference type="OrthoDB" id="1385409at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="22198" checksum="28D6EF62AF4FA3D7" modified="2014-06-11" version="1">MSLAEILNGPPEDAAPAILGRYVRANGVTLRITETEAYAGTAGDPASHAYRRRTVRNASMFEGPGTLYVYFSYGMHWCVNITCGPVDVAAAVLLRAGRVVDGLEEARRGRTVKDRDLARGPARLTRTLGIDREADGTNLLDGKGPLILVDGPREPVGTIRRGPRTGVSQGADTPWRFWIDGDETVSPYRRSPRAPAIRNDALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMW7</accession>
    <name>A0A010YMW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2633"/>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="161"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="29043" checksum="FBBD7858CEFB5E26" modified="2014-06-11" version="1">MSTIGFVGLGVMGAPMARHLVTAGHDVTGFDVHTPAVDAFAADGGAPATSVADAVRGADVVITMLPNHPQVEEVAAQVLPAVPPGTLFADMSSIRPETSVRLAAEGAATGVRVIDAPVSGGQTGARQATLSIMVGGDEVAFAAARPVLEVLGTPRHVGGAGAGQVVKAANQLVVAGIYALVSEAIVLLEGSDVGAKTGLDVLAGGLAASRILDLKRESMLAREFTPGFRIDLHHKDMAIALDAARDAGVALPVTGLVAQLVAAARAMGHGSLDHSALLKVTETLSGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN44</accession>
    <name>A0A010YN44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein involved in propionate catabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851019.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2700"/>
    <dbReference type="HOGENOM" id="CLU_026574_3_2_11"/>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="260"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="434" mass="44396" checksum="EF443084CCD64A7F" modified="2014-06-11" version="1">MSTSPVDDLAAWAAGLRTVDLPGGVTDRLETVLASVLGVTLVGSAGRSALVEAWDPPPGPSVLIGTGRSTTPDAAAWLNATALVSLELDEGNRFAGGHPAAHGWPAVLALAGARDADGPTTAAALVVAYEVAARFGRATRLRPGTHPHGTWGATGAAAGCARLLGLSADAMAAAIDTAAGMAIAGPFVAALDGNPVRDEWVGAANQSGLAAARLAAAGAARDTGIARHSLGGLLGTFDPGPLNEGLGERWDLELGYFKRHASCAYTHPTADAVLDLRPRVPLEDVERVDVETYTAAAALDRVDCPTRLAAMFSVPFVVATALREGAVRPDAFARIDAARPLMARVHLTVAPDLDAAVPEHRGARVRVTLRSGDVVTAAVADPIGDTARGPFGAADVEALLADLLGSAADAERVCAVARELPWLGSVRRALRELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNQ0</accession>
    <name>A0A010YNQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851226.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2867"/>
    <dbReference type="HOGENOM" id="CLU_713131_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="376" mass="40716" checksum="DF791B1562FADAE2" modified="2014-06-11" version="1">MTDLDRALRATMAHRAADAPRADGLMTAVLDRGRRQRRRRLIAGVLSLALIVGGGVVGTAVVWHPDEDRTLQITDGRAPWPDPAPIRPGWLPDGFDEPRVLYLRPGTWGFDSYRTSPRAWLSVDVMSREPELRRGPGERRAVEVDGADATLYWVPTHALGDPKYGTEPPESMGPFGELTYQRRAGQWVRIAASNDEGGSMGLTEADLVEIAENLTDEKQPVADVVRMTLPPGTEVGRVEAGGSRATLVLVDAGAPDEPVSLAEWPGTLNTGEAGPTGARMTVLLTRSDDPELTRFNTSNATSARQRYEDLTAPVKLPPGGALFRDGSSVWYLHPLPGHDRMTIAIRAGSTDPLATADTLRSIAESVRPGPDAKFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNU6</accession>
    <name>A0A010YNU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2823883_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="66" mass="7307" checksum="D67F7DEAA16D6145" modified="2014-06-11" version="1">MPRGSVEGMRSSFVTTRAITTIVVSIILGVVLYQFSGDPRMSLFVFLATAFCGYMYTMISVATREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPM4</accession>
    <name>A0A010YPM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3239"/>
    <dbReference type="HOGENOM" id="CLU_222596_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2379"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3829"/>
            <end position="3904"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5490"/>
            <end position="5565"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="6974"/>
            <end position="7049"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="8472"/>
            <end position="8547"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="9968"/>
            <end position="10046"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="11392"/>
            <end position="11467"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="12879"/>
            <end position="12954"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="14358"/>
            <end position="14433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3534"/>
            <end position="3561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4894"/>
            <end position="4915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14475"/>
            <end position="14508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="4894"/>
            <end position="4911"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2414"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3864"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5525"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="7009"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="8507"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="10006"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="11427"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="12914"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="14393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="14508" mass="1505643" checksum="B3419F5207E96CE0" modified="2014-06-11" version="1">[encoded data, 14508 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ37</accession>
    <name>A0A010YQ37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729041_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="40129" checksum="E77B26B6B551870C" modified="2014-06-11" version="1">MLLAPTETLLSTRPDSDRKESSPMAQPIDPRQLRPRRLWYGIAVFIAVLSIALGIGGLAVSDHLMDNTYPDFQTYSGKEVSLIEVDASRDYGLYVPKNARQFCTVGSLTATPRDEEPWEFTRSGQRWVHVDTVRPNESGPYSVKCDAPTYGFGDPPPFDQYRLQAGSGLAALLGLPCLGLTICFAIALVTGLRRGRHKVRLQAARTATTPNPGPPNLGPRYLGPVGSGPALSGSALSVQPSAPPAPPMTPPPLPTVRRRPASIAVAVLMIGLLVAHSAIAAVLAVLNDSGGSGANIFTAFLAFVLGVALWQGTRVGWIIALAIGVIRLLLTGLAFLVDGDDPSGGWIFAVIGIVIGVLLVAALLLPASRDYCWGEKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQM1</accession>
    <name>A0A010YQM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852333.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084215_2_1_11"/>
    <dbReference type="OrthoDB" id="1923580at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="22154" checksum="2D2353700DC4877C" modified="2014-06-11" version="1">MNRYSRPRRVLRTLGFGRNPMRRRLDRVDALLRVVTALLAIGLVTTAGDLAATRYRTAVDHRADQLRHRHEVTVVLLADTVSTSNGSSAPVHRQRSPVRARWTQPDGTVRTGDVYSRHPGVKGDRVAVWFDETGTPVPALITVGDLRAQAWTMALAATGFGGLVLFAVYTSAQAVLDHRRYAAWAAEWAAVSPRWRHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQU2</accession>
    <name>A0A010YQU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate dehydrogenase/leucine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852448.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3734"/>
    <dbReference type="HOGENOM" id="CLU_025763_0_0_11"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="6">
        <location>
            <begin position="142"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="37252" checksum="C39A73E2BC048650" modified="2014-06-11" version="1">MIDDVFGSGHEQVVLCHDEESGLRAVIALYSTALGPAMGGTRFYPYRSAQAALDDALRLSTAMAYKNALAGLDHGGGKAVIIGDPDKHKSETVLRAYGRFVHGLNGRYLTACDVGTFSPDMDVVARETPYVTGRTVANGGAGDSSILTAWGVYQGMRAAAQHRWGSPDLGGKRVGIAGAGKVGSRLTELLIEADARVTITDPNRSAIDALVGRFPGVDVVAGTEELIDVDLDVYSPCAMGGAVSRASLASLKAEIVCGGANNQLAEAGIDREMAARGILYAPDYCVNSGGVIQIADELQGFNFERAKARATGIFDTTLRVLELAASTGVTTAVAADQLAEERIAGVSRLLRLYRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YS02</accession>
    <name>A0A010YS02_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853144.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_7_1_11"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="93" mass="10198" checksum="B3952CC2E22988D4" modified="2014-06-11" version="1">MATFLLTYGYHDTPLRAERRDDHLAHLASLTERGHLLAAGPLADLTGGVIVLEADDEAAAQALVDQDPYTILNVTKDRSLREWKLTAGRLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV39</accession>
    <name>A0A010YV39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927217_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="32548" checksum="8A7627C8164F3EE7" modified="2014-06-11" version="1">MLFTDAEPVSDDALLGLVYEVCPRFVPGTVLHRSATSFVVAGSVDLSPVVAKVLAGGAPFWREHFLREVEAYRLFESVPPPVRTPQLLAADAERGVLLLERVFGRPLARERHPTVPIPPTELAGALTELRQLAKWQPPVGQSWIVNYTPRIDRARRQGVFDDVDRAAVAELARRSAGRWELAHGDPVLDNVLSTRDGFVFLDWATAGLYLAGFDLAQLWVLLGELHGPRRAIEDLVDDGGPAAVEPFLVNVALLLGRERRSYQHRTDDVGVARRARLAETWNEVRARVHRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWK0</accession>
    <name>A0A010YWK0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848258.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.556"/>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_11"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03914">
        <property type="entry name" value="UDG_fam_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="208" mass="21926" checksum="F1E4E26475290967" modified="2014-06-11" version="1">MDASTLIPAQADLPALKSAAARCTACELFEPATQTVFGSGNPQAKVLLVGEQPGDVEDQRGVPFVGPAGKLLQRAVAEAGFGPGAVYVTNAVKHFRFELRGKRRIHQTPQPEHIRACNPWVAAEIAAVRPRIVVCLGATAVKALLGSTYRVTKDRGALMPYTGPGAEPETRALITIHPSAILRMPDDAREQGYADLVADLAVVAAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX74</accession>
    <name>A0A010YX74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="5">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848520.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.781"/>
    <dbReference type="HOGENOM" id="CLU_010186_1_1_11"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="6">
        <location>
            <begin position="176"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="39410" checksum="902FF07F9D5835E4" modified="2014-06-11" version="1">MTLVEPHTSTTNWYEARARARGCANPRPAETVPLGSAIGRVLADAVHSRTMVPGFDTAAMDGYAVAGSGPWRIAGRVLAGTADPGRVEAGAAVEIATGAPVPDGTSAVIPYEETAVAGGVLEAPAPQRRHIRRAGEDLRRGDVLADAGRELTPTLSGLLAQGGADTVAVRRRPVVRIVVTGDEVVQAGLPQAGQVRDALGPMVVALIEAAGAAPPSLVPVPDEFSRLREALVREGPDVLVVTGSSSVGRADHLHAVLAELGAALLVDGVACRPGHPQLLASLPGGRWVVGLPGNPFAGLVGALTLLVPLLDGLLGRAARPVFRLPVVGAVRAPGAITRLQPVRLGDGVAVPVADAGPARLRAAADADGVAVLEPGWEPGALAEILRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXK2</accession>
    <name>A0A010YXK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase component of ABC transporters with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.954"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="287"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="596" mass="65210" checksum="279C82837EDF894C" modified="2014-06-11" version="1">MAVNLVNLENVSVSLGTRTLLDQVSLGVGEAERIGVVGLNGAGKSTLLRVLTKEYQPDSGRVTQRGDLRLGHLTQSVNFPDDAIVREIVLGGSFDAEHEWAGDARIRTVLDGLGLNSIGLDAPVAKLSGGERRRVALAALLIKDTDLLVLDEPTNHLDVEGVAWLAEHLKSKRGGLLVVTHDRWFLDAVCTRTWEVTEGRVEQYEGGYAAWVLARAERSRQSAAAEERRQNLMRKELAWLRRGAPARTSKPKFRIEAANALIADVPEPRDTVQLKRLAGTRIGKQVYDAEDVSLRFGDRTILNHITWRIGPGDRFALVGVNGAGKTTLLRLLAEQNEPDSGEVKVGKTVKAAYLSQEVTELPPTLRVLQAVEEVAQRLTVGDRDLTASQLAEMFGFSSARQWTPVGDLSGGERRRLQLLRLLMAGPNVLLLDEPTNDLDIDTLQALEDLLDSWPGTLVVVSHDRYLVERVTDQVWALLGDGALRMLTGGIDEYLERRAAAGAGSGRAGAAEAPRPAVSPAVGDAPTAADQRAAKKELGRLERQISKLEERERKLHDRLAENATDFAKVAELDAELRTLQAEREAAEESWLELSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY16</accession>
    <name>A0A010YY16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_1163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1140"/>
    <dbReference type="HOGENOM" id="CLU_011899_7_1_11"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="568" mass="63268" checksum="A39E36E673B5600F" modified="2014-06-11" version="1">MTIEAERIEPEPIVSRPWPVRESVKGNALARIIRTTDAKQIGIMYLITSFFFFAAAGIMALLMRAELARPGLQFLSNEQYNQLFTMHGSVMLLLFGTPLGFAFANFLVPLQIGAPDVSFPRLNAFAYWAFAFGGLMVLSGFLTPGGAADFGWFAYAPLNSEINSPGAGADLWIVGFAISGLGTILGAVNIITTILTMRAPGMTMFRMPIFTWNMLVTSLLVLMVFPILTAAFFGLLADRHLGAHVYDADTGGPILWQHLFWFFGHPEVYILALPFFGIITEIIPVFSRKPLFGYKGLVGATVAIAALSMTVWAHHMFVTGAVLLPFFSFLSYLIAVPTGMKFFNWIGTMWRGQLTFETPMLFAVGFLVTFLFGGLTGVLLASPPVDFHVSDSYFVVAHFHYVLFGTIVFAAFGGIYFWFPKMTGRMLDERLGKLHFWLTFIGFHTTFLVQHWLGNEGMPRRYADYLASDGWTTLNTISTIGAFILGISTLPMIWNIWKSYKLGRVVTVDDPWGYGGGLEWATSCPPPRHNFLELPRIRSERPAFDVKFPHLAPWANEVKNQQQPSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ12</accession>
    <name>A0A010YZ12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849357.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129452_0_0_11"/>
    <dbReference type="OrthoDB" id="1997747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="PTHR34129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="102" mass="11069" checksum="88B8B52DACB99094" modified="2014-06-11" version="1">MTTVYKVLRADEWAAAQATEQYEGSPDDLRDGFVHLSTAAQLPGTLDRFFAGETDLMLLAVDTDPLGESLRWESSTGGDPYPHYYGALPMSAVTEATPVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZC2</accession>
    <name>A0A010YZC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="13218" checksum="382C61246BF96B2E" modified="2014-06-11" version="1">MARILIVEDEPDMRELMARKLGSVGHEVTSTRSGAEGLSMLRSTRPELVLLDVQLPDTSGLSFCETVRADAELRDTLVVMISASAGQEEVDAGLAAGADDYVTKPFAPSKLIQRVEALLSSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZZ1</accession>
    <name>A0A010YZZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1805"/>
    <dbReference type="HOGENOM" id="CLU_128738_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="13905" checksum="E217E00BC333BFF3" modified="2014-06-11" version="1">MNEHEPMASRWKKASPVLLAGGLATIGVLHFVAPKPFTRIVPRALPNPEALVAISGAAELACAALVAIPRTRRFGALASAALFVGVYPANVQMAVDASRTSNATYKAIAYGRLPMQFPLIAWALSVARPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z171</accession>
    <name>A0A010Z171_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2393195_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="87" mass="10200" checksum="77FAE092DC53B1AF" modified="2014-06-11" version="1">MTLRSERLLEELAAVEHERWAHWQRYLHSRGERAADGSLVLPAELVERWERQIATPYAELSEAEKTSDREQVLRYLPVIEAVLNDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z187</accession>
    <name>A0A010Z187_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type metal ion transport system, periplasmic component/surface adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850414.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2266"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_11"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="31184" checksum="12142F578DC8E40B" modified="2014-06-11" version="1">MRALLAVFVLLGVAACTAPDDGGPRIVVTTNILGDVVRAVVGDEADVTVLMKPDADPHSFAISAREARAMQTADLLIHNGLGLEEGIARHVAAAGVPTVEVGALVDPIEYRDGDAAGLPDPHFWTDPVRMVAAVRLLTDEIVDHADVDASAVRARAEDYTAELDALHADLRRRFAAIPAARRVLVTNHHVFGYLAERYDLTVVGAIIPSGTTLASPSASDLASLTTAITRHRVPAIFADTSRPARLAEVLASSAGLTVRVVALHSESLSGPDGDAATYLALMRFNADAIVGGLTRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z191</accession>
    <name>A0A010Z191_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850421.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2271"/>
    <dbReference type="HOGENOM" id="CLU_044590_3_0_11"/>
    <dbReference type="OrthoDB" id="1979322at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="28932" checksum="810C57FB02919C00" modified="2014-06-11" version="1">MRIDAHHHLWDLSRRPQEWLEPLGPIHRSFGVDDLPPGFDHTVLVQVLADLDETREFLALAAASDRIAGVVGWVDLTAPDVGDVLDSLPAGLVGVRHLVQAEPDPRWLLRPDVQRGLRAVGARGLVYDLLTLPPQLPAAIELVTTLPDVRFVLDHLSKPPLATGDLASWAGELRRLAAAPNVVAKLSGLVTEANWASWSVADLRPAVEVAVESFGPDRLMFGSDWPVCLLAAPYADVVKATEELVADLSADERAAIFGGTAAATYGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1N9</accession>
    <name>A0A010Z1N9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">CryarDRAFT_2444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850620.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2407"/>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_11"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="41"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="423" mass="44656" checksum="FB0A9061D433DB29" modified="2014-06-11" version="1">MNYLIRGATLPDGTTRDLAVRDGLIAETTDGEVIDAGGLRVLPGLVDIHTHLRQPGREDAETIETGSRAAALGGYTAVCAMANTDPVADAAGIVEQVWRLGREVGLVDVQPVGAVTLGLKGERLAELGAMAESAAGVRVFSDDGHCVHDAAVMRRALEYVKAFDGVIAQHAEDPKLTVGAQMNEGEQSARLGLAGWPAVAEEAIIARDALLAAHVGSRLHVCHVSTAGSVEVLRWAKSRGIRVTAEVTPHHLLLTDELAATYDPVYKVNPPLRTAEDVTALREALADGTIDAVATDHAPHAREDKECEWAAARPGMLGLETALPIVIKTMVETGLLDWAGVAERMSHAPARIANLESRHGRPLTPGEPANLTLVDPAQRWTVTPDGLASISRNTPYTGLELPGAIVATFLRGRATVLDGKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2C5</accession>
    <name>A0A010Z2C5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850944.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2656"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_2_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="20119" checksum="ED808681A5CC71B5" modified="2014-06-11" version="1">MERRERADAARNRRAILDATEALLARQRPETISMELVAAEAGVGKGTVFHRFGSRMGLMVALAQERALGLREAVESGPPPLGPGASPAERLPAFLDAAVDVVVRNKNLLAALGHAEASAPHDHGDLADHPVYRFWHAHVVSLLTGDDTDALAHVVLAGLRSGPVIAMIDRGEAERVKRALRTIVSGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z557</accession>
    <name>A0A010Z557_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Usp family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852307.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3634"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="155"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="27542" checksum="553F6E877AF595C9" modified="2014-06-11" version="1">MTIDGATERGAVQEREARGAVVVGIDGSPGGTRALDWAAREAAARGARLHVVVAEAEPSARGAGQGELDRAAIRCRTTAPGLPVTGTVRPDSPAAALLAVAADAQLLVVGRSGRGGRVGTHLASVPAAVLRFAGCPVAVVAGGRTGRPPEWAGEVVVGIDGSAADRPVLAAAFGEAGARRGRLTIAHAATVGAHTDGAATARALVDAAIGEWSPRHPSVEVAGRVVHDAPVRALDGLSTGAALLVLGAVGRNAIPSELLGAVPRALAGQAACPVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5K2</accession>
    <name>A0A010Z5K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852547.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791589_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="36868" checksum="BF8EC761C2E105F0" modified="2014-06-11" version="1">MTRWWSAIVVGVVFAVAGCGGDAEPAPTESSPSPVPTASTADAGYVDRSISDSFLPRFDGIRKFGESAFLQGEGWRTALSWSVTVRNLEAHDARVFKAFLGSRLKKYGTYGRAPEMDLLAAPGHEFLVTYLSETDGVKTAPGKPEPGPYQVLVGGKARPLDLDPSESDVLVVVSVPVGADATLRHTYQGRTAEISLRTGKPGGPAAGACGATAGTDSAHFGARRGDAYLSATFEVTASLTSYLEGRGWAKGGRCWMTTRITATYWTPRMGPEGTSSPPDGFSGLEPTIVGVTVDGRRYPVGATAFDVAESAKTVRVTVRPRAPRKDGTPVAWANLSGVTAPEAATITLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5S6</accession>
    <name>A0A010Z5S6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852626.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3857"/>
    <dbReference type="HOGENOM" id="CLU_153642_1_0_11"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="95" mass="10793" checksum="80994C954C90452F" modified="2014-06-11" version="1">MPEWTFLTNHAHVLLCIARDPGVRFRDLAGQVGITERAAQRIVADLARAGYLTTTRDGRRNRYKLDPSLPLRHPLEQQHLIGELLDILRDPPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5Y6</accession>
    <name>A0A010Z5Y6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725731.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3898"/>
    <dbReference type="HOGENOM" id="CLU_1452199_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="19830" checksum="259A8A26CDE4FC97" modified="2014-06-11" version="1">MTPRTVPIAFRRHLGTTPMAYLRRVRLDRAHADLLAAVPGEGATVAGVAARWGYGQPGRFAGDYRAAYGRLPYRMARARLINTMVGHEAETGADLATARELVARLATHVTRLRVATAACAAPPVAHPAEPCALLDEHARVLRAVAGIVEALGSLATAGRRRRDDLEAEVVELRGSAHRLSACVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6L0</accession>
    <name>A0A010Z6L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853027.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4121"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="23222" checksum="F741CE2511041554" modified="2014-06-11" version="1">MTLLTVTGVHRHFGTVHALNNITFSIEPGTLVALVGRSGSGKTTLLNIVGGLDRPDQGTVTIDGTDITTLDENGLSTLRRDTVSYIFQTFGLIPVLTAAENISVPLRLTRTNPHDRDKRVDLLLDLVGLGDHARQRPGELSGGQQQRVAIARALAASPRLLIADEPTGQLDAETGLAVMALLKGIVQTEGVTALVATHDPVLMALADHTLHITDGHLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6T3</accession>
    <name>A0A010Z6T3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853304.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4203"/>
    <dbReference type="HOGENOM" id="CLU_059206_0_1_11"/>
    <dbReference type="OrthoDB" id="1395053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="36136" checksum="8CBEF3BE9FEA6EBC" modified="2014-06-11" version="1">MPNVLATRFQQSFDADTRSRFFRGMDFRSPEGDPGWFGPDSAVWYVHSHTPAVILGLVAASYIEGLDPSISWMGYDHSRLVERKDGVPTGAIDEEGGKVRLGHSVAFFIGTAYGSTKTAENLARTVRAMHHTVKGVRPDGLAYDADSPEWLRWNYATVVWGLATAHERYHRAPLADIDRYYREFVRVGEALGGTDLPTTKQETLDCLESYLPKLAVTPIKAFATGPNLRGNGRRAWEPGSEFLDWAVRDMLPGWAQKLAMYQRPNPVALRLRRAALRAVVNGAESPLREFHEARARVAAGVTASVTSTRPESPDPTRTRAEVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK04</accession>
    <name>A0A010ZK04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="2">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569511.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.6"/>
    <dbReference type="HOGENOM" id="CLU_025068_1_0_11"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="3">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG78994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="42348" checksum="5CF1B310E89DCC89" modified="2014-06-11" version="1">MTEEVTLLSTVEAARRLGVKPATLYAYVSRGLLSRVRGADGRTSYFDPAELDQMAHQPRTPAAGNGGGPLVRSSVSEVREQRLWYRGRDACEMARTEPFEAVAGWLWSEDRSRPLSFTSPVEFVDAARSASRGLPPTVRLLDRIRAIVAAIGAVDPLRADLRPEAVTITAATLIGALVDGLPRQGGSDGNGSVAQRLWGALSSLPPEPGAVAPLNTALGLLADHAITASTLAARVAASARAHPYAAVGAALYTLDGPVESGSAALVHRTLAEAERDGSVAVVARLLDQNNQLPGFGHPLYPDGDPRGRTLIDVLAAEPPHRGRWEAVEQFLATGGRGRPLAPTIDFGVAALTFTAGMPADAGLAILAVARCAGWVAHTLEEYGEEVDRFHVDAPPRRGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK66</accession>
    <name>A0A010ZK66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847455.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="28129" checksum="95135814DB1C7C3E" modified="2014-06-11" version="1">MKQLDPGWRPKLVALDLDGTVVNYGPARTQPSLAVAAAVGRVIDAGVPVVVATGRAVLDALDTAVALGIHGVELVCTNGAVVYDAETGETTHRVTVDASAAAAALAERIPDAVFAAERDAKGFLTTDGFHREFTVGTQEVVDLATLVSEPVVRLVCVRPGWDVAQMAAVAREVLDPAQYSWDLGFSAWLDVQAAGVSKATGTAMVCADLGVDPSDVLAIGDGTNDIELFKWAGWAVAMGQAMDVVKDVADEITDPVDLDGCATALGRWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL08</accession>
    <name>A0A010ZL08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847872.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.332"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="33635" checksum="D4AE81766DCCDF5B" modified="2014-06-11" version="1">MSEVASPPSAAKRPAGERVAPYLFLSPALVLFLIFVLGPMVGTLVLSLFNWDLLGEPTFAGGDNYTKLVGDETLRKALGNTFEFTFWSIVLHVGLGLLLALGVTRKMWRVTRYFLRTAYFFPFLISWAATALIWKYAYDPAFGVFTYYGDKIGLPGGVLVDAHWAMPALILVDLWHTIGFSFVVILAGLQAIPAHLYEAALLDGASAWRRFWHVTLPMLSPTLFFVTVISFIGAFQIFEPMFLMTRGGPDGATISVVQYLYETAFRNFQVGYASAIALLVFAIVLLATLVQFRLRRRWVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLD6</accession>
    <name>A0A010ZLD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569635.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.505"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="387"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="680" mass="72752" checksum="ACB5FCD1394E77AC" modified="2014-06-11" version="1">MDKFAAEREGLNYDPVDTSSGAAVMRLIRADRVVRLAVIGGLYWLVAYAVFNWVARDEHSPLRTIANALFLVPIAAAVVTAAVAARRRAKESRTGRAWIAFAVSFALWLAGESIWLGYPDISYPSISDAIFLAQFLAVLPGFFVAFGQGHRSRRGRALFDVALVLVGLGALGWRLLAAPQLTDTVGVSLVVTAAYPLADILVLVCLLTLGLSGHRRLPVSVRLAGWAYLVYALTDCLYMYGRIHQTYDDGSWLDNGYQLAAVLLAIGGLVAARHREPDAVRLAVGRDLTVVPLLAAGTAASVGLTLEFARHGGNYAALVVGLVVVAGLMVRQYLVTRDRTDLARQLAGALREQERLAVTDPLTGLHNRRFFDDTMRTEVARARRTGRPLALVVLDLDHFKKINDERGHQAGDLTLMQAAARLQAVTRGGDVVARFGGEEFVWLLPDTDETGAAILAERLRSALCAQPVEVSETGLVSVTGSLGVASASGLVDDEALMRDADRAMYHAKATGRNRVVRASTIAEAPAEPAPSEGSRSAGPTDGLDGAGVVAELCAQVADRVGLDEFQLRLVVAAGRVAALRSPVLSRTDRTALHPTSDTTDPEMLALIEALDAPGCHPASSRIISACLNWAENRSRGVPVASRAEDRTIGFDDAAVDELVATVRADIVTAIETLPETVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMA0</accession>
    <name>A0A010ZMA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848536.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632188_0_0_11"/>
    <dbReference type="OrthoDB" id="1999489at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="77" mass="8540" checksum="AAFCD8AB759112A7" modified="2014-06-11" version="1">MVARFYRRPDGNRIASLGHYTYDGRDTLLAWGWVGDPHCAFHAVGRPGHGWDAPRPGCPRAELVLDEADRVVGVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMR7</accession>
    <name>A0A010ZMR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1011"/>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_11"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="35974" checksum="93BFF61AB9933A05" modified="2014-06-11" version="1">MRVVVTGGAGFLGSHLAAALLARGDQVVCLDNFSTGRLENVEPFLADPAFALVETDVSEGIDVPGTVDAVAHLASPASPPDYHRMPLETLAVGSRGTEHALRLAARDRARFVLASTSEVYGDPVVHPQREEYWGNVNPVGPRSVYDEAKRFAEAVSMAYRRTYDLNVGIVRIFNTYGPRMRPQDGRVVTSFITQALVGDPLTIYGDGEQTRSFCYVDDLIAGIVAMIDGSESGPVNLGNPVEWTVTRLASAVLALTGSSSEIEYHPLPTDDPTRRRPDITLARQLLGWEPRVPVEEGLRRTIEWFRSRPEELLAAAPALTGAQPGGIEALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN53</accession>
    <name>A0A010ZN53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848905.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1164"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="193"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="43029" checksum="EB912BADB9FE1287" modified="2014-06-11" version="1">MAPRNLEADEREETRAGESSRRDLVVDVICVVAAFALPLGFWIALALGHDVAQKPLQRIDLVLATLAAPLVWWRRRWPMTMSIVVSVIASVSTLAAVPQAITLITVAIRCRPRLVVAATAVFVVTGSIFSVVQPNPTLPLWAAVLAVVLIAGILVAWGSFIKARRALVDSLRDRARRAEDEQSLRIEQARQLERTRIAREMHDVLAHRISLLSLHAGALEFRPDAPPDEIAKAAGVIRTSAHQALQELRDVIGVLRAPNGGEADRDRPQPTLGDVPALVTEARRAGATIDLDVRVDDPAAVPAVIGRTTYRIVQEGLTNARKHARGAAVRVTVSGDQGDGLTVEVRNWLPLRAETSQIPGAGTGIIGLGERVGLAGGHLEHGPSTAGDFRLKAWLPWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP82</accession>
    <name>A0A010ZP82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1545"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="265" mass="27974" checksum="FAF247FBC25DF55B" modified="2014-06-11" version="1">MRVSATGIDVAIAGRTIVADAVLDAPSGAFVGLLGPNGSGKTTLLRTVYRALRPARGAVLLGHTDVWSLTARQAARRTAVVMQDDPTEFEFTVREVVGLGRVPHQNLLGRATGEDQRAVDAALARTGVEHLAERPVSSLSGGERQRVFLARALAQDTPILVLDEPTNHLDVTAQLELLELVRGLGVTVVAALHDLNLAAAYCDQICVLRAGRLVASGPVADVLTADLIAEVYGVRAALVTNPLTGQRGFAFAPSPESVTQMKEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP92</accession>
    <name>A0A010ZP92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of Mn/Zn ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569899.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1556"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="31353" checksum="3EA7F96CC6E30FAC" modified="2014-06-11" version="1">MAAPRNDLLEVRRATLAYGSRVIWQELDLAVRRGEFLAVLGANGSGKTSLLRVVLGLQPLSSGTVLVDGARPRRGSNAVGYVAQQRASDSPMPQRAKDLVGQGLDGHRWGIGLPGRDRERRIRAALDEVGALSYADWPIGALSGGEQQRVRIAQALVADPRLLLCDEPLSWLDVTSQQTISSLVDRWRREHDSAVLFVTHDINPVLPYVDRVLYMAGDGQHRLGTVDEVLTGDTLSALHGAPVDVVRLRDRIVIVGLPEAAHPHGAHPDPAHPDPAHPEPARPEKVHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPF6</accession>
    <name>A0A010ZPF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847563.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.127"/>
    <dbReference type="HOGENOM" id="CLU_001832_3_3_11"/>
    <dbReference type="OrthoDB" id="58588at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150658" checksum="B040E2D285D80E16" modified="2014-06-11" version="1">MNNATAEPINLADLRSRLPELMLRDEHRLRRQLDRTRPDKLPALAAQIATAEAKITTRRESVPEISYPPDLPVSQKRDDIAAAIRDHQVVIVAGETGSGKTTQLPKICLELGRGIKGLIGHTQPRRLAARTVAERIAEELHTELGDAVGYTVRFTDQVSDGTLVKLMTDGILLAEIQRDRDLRRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKLIITSATIDPERFSAHFGDAPIVEVSGRTYPVEVRYRPVIDPDDENADKERDVTTAIIDAVHELSGEGPGDILVFLSGEREIRDTADALTKENLRNTEIAPLYARLAAAEQHRVFQPHTGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSLRTKVQRLPIEPVSQASANQRKGRCGRLSDGICIRLYTEADFESRPEFTDPEILRTNLASVILQMANLGLGDIAGFPFVEPPDKRNITDGIQLLSELGALQTAKAQVDGVQLTAVGKQLAQIPIDPRLARMVLEADKNGVVPEVLVITAALSIQDPRERPTEHQQAADEKHKRFADQHSDFSSYLMLWNYLREQQRELSGSAFRRMCKAEFLHYLRVREWQDLHGQLRQIIRGLGITVDRQADPGGDGQKVVSSLLAGLLSHIGMRDDRTTTKDQPKGRRPLTEYYGARGAKFAIFPGSTLAKRPPRWVVAAELVETSRLWGRITGRIEPEWVEPLAGHLAIRTYSEPHWDAERGAVLATEKVTLYGIPLISGRTVTYSKVDPALCRDLFIQHALVEGEWRTHHKFFGRNRTLLKSAAELENRARRRDLVVDDQTLFDFYDERIPAEVVSARHFDSWWKKESREKPDLLDFSASMLVNRAAGELDIATAYPDFWDADGARLKLTYQFQPGTAADGVTVHIPLAVLNQITPDQFGWQVPGLRQDLVTAMIRSLPKEIRRNFVPAPDVAKAALAGISPADGPLPVALAAELRRLTGISLPVDAWQDDRIPDHLSMTFRVEDERGRRAAEGKDLVTLQRQLAPQVRDAIATALTAPEEPRRSRRGRGRRGSEGAAPNAAGPDGPGAGGHRGSTSTSDQGSETAEAPNIEQTGLKAWTFDSLPEVVERRRGGFLVKAYPALVDEGDSVAVRLLGSPAEQQRAMVTGTRRLVLLTVASPNKVVVSSLSNSAKLALGRNPHGSVAALLADCVAAAADELIAAAGGPVRTAAGFAALRDAVRGSLVDTTLDVLKTVEKVLAAAHAVSALLPSAPATARADVQAQLDALVYPGFVAATGRRRLVNVLRYVQAIQRRLENVRRDPARDRGWQDRIEAVGEVYADWLRRLPPERRSEDSVREIRWMIEELRVSLFAQSLGTAYAISEQRIYKAMDAAGGGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPL5</accession>
    <name>A0A010ZPL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 7">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569930.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1679"/>
    <dbReference type="HOGENOM" id="CLU_053879_4_1_11"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23255" checksum="3283012D45455195" modified="2014-06-11" version="1">MYKIGPVASSPWSRLLQGNARWVEGRSTADADRGAARRAAISRAQNPFALVLGCSDSRVPAEILFDQGLGDLFVVRTAGHALDSAVIGSVEFAVEVLRVSLIVVLGHEECGAVSAASRIVDEGQVPPGYIRDIAERITPNVLRARHAGAVNTTDVSALHAAYTIEQLCQRSPLVDVAVWRGTIAAVPALYSLDSGIVTEVRPRTAYVAMPDEVYATHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPX9</accession>
    <name>A0A010ZPX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849768.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1786"/>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="33175" checksum="19DDE187968EB0CA" modified="2014-06-11" version="1">MGLVVGVDVGGARIAAGLVDPEGRVLIRQTVPTPPRPADLVPCVQALVNAFRGGYTLTAVGLGVAGFVDRDRSTVLFSSLAGWADLPIGAELERSLAIPVAVENSGSAAAWAEIRFGAGVGETSLVSCVIGTGLGGGFVVDGRPYRGRFGVAAEYGHIPVVPGGLLCGCGNRGCWQMYASGAALAREARQLAKSGAGSVEPLLAKSGGDADEIGYRVVVAAAREGDPTAVEMVEKLGRWLGTGIATVASVLDPGRVVIGGGLVAALAGVAAPPDSESLELLLEPARDEFRRSLPGRGYRQEASIEPARLGSDAGLIGAADLARTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ21</accession>
    <name>A0A010ZQ21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD-superfamily subfamily IB hydrolase, TIGR01490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.304"/>
    <dbReference type="HOGENOM" id="CLU_052657_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33276" checksum="D164D1EB3C695FB6" modified="2014-06-11" version="1">MSVSANVGDERPAERRPHVDSDLPRAADPVAPGAPSTVTPATARSAAFFDLDKTVIAKSSALAFGKPFYQGGLITRRAMLRSAYAQLMFQRAGADEAQMARIRDSVTAMITGWNVSQVRQIVAETLHELIEPTIYAEAAALIGEHRAAGRDVVIVSTSGEEVVAPIGALLGVDRVVATRMAVVDGHYTGEIEYYAAGPAKAAAIRELAVSEGYDLADCYAYSDSISDVPMLQTVGHPFAVNPDRGLRKAALEHDWPVLVFRRPVTLPTRFVRPSTPILATAAVGFGVGAAALAGMVWYGRHRAKLAPRVSAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ63</accession>
    <name>A0A010ZQ63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569603.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382111_0_0_11"/>
    <dbReference type="OrthoDB" id="2031675at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459203" evidence="2">
        <location>
            <begin position="27"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20795" checksum="2D26ECEF94C0D2DC" modified="2014-06-11" version="1">MRLKLGVFVGAMTVLVLAGGGSAAMASDGGGQTHPTSPSIEIASERPTSSVDVEKFTKCMRANGIPDFEAPTVTPPSGDEPGRIESVLPKDVDPEVARKATEKCAPGSLPTKGRISAAEVTKLKRYAKCLRENGVEHFPTPSADGSLRLSKDEVDPESDEFEAAEEACKKYAPARGAKERHRSSDRGPILYSRAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQD3</accession>
    <name>A0A010ZQD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079635_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19881" checksum="A53267D26DBCDE80" modified="2014-06-11" version="1">MPIDTAKLAPLGLRVVARLIDIVAVFLLCLVVNGYFYLQFADQVGPNINDILLGQETLSAEASRLNWIIFVLTIGLWFAYEVPATANSGQTLGKRIVGIRVVRVVDDKSLTFGQSIRRWLILMLPSPAVSFLCGLPLQIADLLWCLWDRPGRQCLHDKAVTSIVVRSAAVPAPEKVKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQI0</accession>
    <name>A0A010ZQI0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSDR_N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.489"/>
    <dbReference type="HOGENOM" id="CLU_1438900_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="20462" checksum="89D4DA172C27CA27" modified="2014-06-11" version="1">MRRGLLRCDRTAKATPSGPTPTASGCRFVMPFISTILGYDVFDPLEVVPEFTADVGTKRGEKVDYAIMRDGEVQILVECKKSTGPLRVENVSQLFRYFSVTNARIAVLTNGQVNDRLKTALSASYAAPAGTAAPADAITSQPVAERDIDRDTEITTTLEELEGYQIVKAIACSEVKPDRAVIWDSRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQY2</accession>
    <name>A0A010ZQY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850247.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2145"/>
    <dbReference type="HOGENOM" id="CLU_915012_0_0_11"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="31487" checksum="265E1CACFB79F0A6" modified="2014-06-11" version="1">MRIDVHQHLWPQPLIEALRARTTPPRLDGWTLHTASAPPFDVDPADHDVAARIALIDADGLDRALISLSSPLGIEWLPDAGDLLDAYHEGVTALPGRFGAWAAAGLLPVDPGALERALDAGCVGLQLPANALLDPAGYAHCAPLLDVLERRSAPLLVHPGPHPAPPDGAPGWWPALSPYVHQMHDAWHAFLAFGRAAHPTLRVCFALLAGLGPLHGERLAARGGPARRPVDMDAFVDTSSYGPRAVDAITRVLGVDLVVLGSDRPYATVPDFGLGDAFDHALAVSNPARLLYGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRH2</accession>
    <name>A0A010ZRH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848556.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2823882_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="66" mass="7109" checksum="86024C66AA7CE684" modified="2014-06-11" version="1">MNPDFVASTNMLPYDPALLWKAAIVLVVFFGVARLIYKKEPRKGLGYSITVGAAAAGLVAFLLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRV2</accession>
    <name>A0A010ZRV2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="9" type="ORF">CryarDRAFT_2485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850679.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2448"/>
    <dbReference type="HOGENOM" id="CLU_027172_2_0_11"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023278271" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023278270" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="260"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="464" mass="46208" checksum="526F98C2A72F57EC" modified="2014-06-11" version="1">MSVTSAQGFGAAGVAAGLKTSGDRDVALVVNHGPLDAAAGVFTSNRVKAAPVLWSEQVLKSGRLTAVVLNSGGANACTGPEGFQDTHATAERVAERLGCGAADVAVCSTGVIGERLNLPALLRGVDTAAAAAASKPAAIAAADTPAAIAAADTPAAAAAADTPTAAANKPTAAATGKPAAAASTPAAASTPAAAGTPTATEASTKPADKSATPDNSGGQAAAQAIMTTDTHPKTVTIDNKTWVVGGMAKGAGMLAPALATMLCVLTTDAVADADALDTALRAATKTTFDRIDSDGCMSTNDTVLLLASGASGISPTQTELNQAVEAACADLARQLIGDAEGASKEVAITITGAASEDEAVTVARSISRNNLLMCALFGNDPYWGRVLAAIGTTDATFDPDRVDVSFNGVKVCVNGTKNPEVEAPNIEDRHLEVHVELNAGEHTATVHTNDLTLAYVHENSAYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS41</accession>
    <name>A0A010ZS41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
            <ecNumber evidence="2">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850818.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_7_11"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="118" mass="12926" checksum="CF7F3484F694CFE7" modified="2014-06-11" version="1">MATGVASVWVPVDDMERAVGFYRDVLGLELTDQQPQWSELDAGGLRIGLNAREGVSQHADGGAVISFRPDDDLESEVDRLRGAGVRFTGDISDHEWGRIVPFKDSEGNDLQLYAPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS42</accession>
    <name>A0A010ZS42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2022871_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="14002" checksum="D1C12EDCCACD64E6" modified="2014-06-11" version="1">MSIIHEIPTQRHETTPPAPSARPHWLRTPCPAWCEWEHRDGDRRGDRQHMAFAGRIELALYDPAEAADDTYQPETLGVALDQHVDNAEPVVILYRENDEVRLTLAEAEQLRGRLDWALAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSD3</accession>
    <name>A0A010ZSD3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ORF">CryarDRAFT_2711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850963.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2672"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_11"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="261"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="54854" checksum="354C41F61A09022B" modified="2014-06-11" version="1">MPDFVGAVDQGTTSTRFMVFDHGGNEVGRHQLEHEQILPQAGWVEHNPVEIWERTASVIRTAMNNLNLSASDLAALGITNQRETTVVWDKRTGRPYYNAIVWQDTRTDRIASALDRDERGQTIRQKAGLPPATYFSGGKIQWILENVEGVREAAEAGHAIFGNTDTWLIWNLTGGAHVTDVTNASRTMLMDLETLDWDDELLSFFNIPRSMLPEIRPSSDPAGYGSLEAGGPFRGDVPLTGDLGDQQAATVGQVCFAPGEAKNTYGTGNFLLLNTGNELVRSEHGLLTTVCYKFGDQAPVYALEGSIAVTGSAVQWLRDQLGIISGASQSEALARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRYNTNAHLARATLESICYQSRDVSEAMAQDSGVTLDVLKVDGGVTANSLCMQLQADILGVPVSRPVVAETTALGAAYAAGLAVGFWKNTDELRENWNESERWQPSWSEERRTEGYAKWRKAVERTLDWVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSF7</accession>
    <name>A0A010ZSF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851027.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2709"/>
    <dbReference type="HOGENOM" id="CLU_030671_0_0_11"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="28001" checksum="ABC1C5FC9C850FB9" modified="2014-06-11" version="1">MSDALLDAVAAGVTIHDLGRTFFPGMPQSPNHPAYTHTLPRRHGDMVRADGASAANDLIVLGTHVGTHIDALAHVSFQGKLHGGADAHEAVAGGRYLEHGVHTIAPMVRRGVLLDVPAALGAECEPGYEITVSDLEASARAEVRPGDVVLIRSGWGRRFDDGAEAYVGRDSGVPGISEAGAKWLAAKGIHAAGADTIAFERLAPGGGHASLPAHNVLLVEHGIYLIEAMALEELAAAGVAEFTFVLAPLKLLGATGSPVRPLALVSDGGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSG4</accession>
    <name>A0A010ZSG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848951.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1208"/>
    <dbReference type="HOGENOM" id="CLU_044469_0_0_11"/>
    <dbReference type="OrthoDB" id="1463272at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="480" mass="50330" checksum="68A25E741AE63868" modified="2014-06-11" version="1">MTTVHEASDEVSVWEDDPGAPPSTRTPVLRARPALRTAPLAVDVQGAVPPDAEGAVRYWTAAEALGRTVALYAPLFPADEFPNGAAWNPAVGDVLVADLNAGVDLNAYYDRGGLAFFRQHVSGVTVWSGESPDIVSHETGHAVLDALCPWMWDAASAEIAAFHESFGDMTAVLAGLRLATLREQVIGETGGELSRSSRLSRLAEQLGWAVRQLAPSSADPDCLRNASNELFYRDPVTLPPSAPASQLSSEPHSFSRVFTGAFLRSLAGMVHTVAGTGQVDDEALLTAGQDAATLLVTAVTDTAAVPSYYAQVAAHLIEADQEKFGGKYAAALQAAFVRHGILSPASAEAIIDGATGDDDEKVGERSIAPGAPHPRGASTSEVAVSGRPYGLPEDLTVHAPVEAPRFSVAPAALSRGELVTTPGEDVAAAFVEDLFRQGRVAVPREYQRGFAAASGVDGTLRTHEVANNGAGLVLVRRVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSI4</accession>
    <name>A0A010ZSI4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative hydro-lyase CryarDRAFT_2772</fullName>
            <ecNumber evidence="3">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851065.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2734"/>
    <dbReference type="HOGENOM" id="CLU_059759_0_0_11"/>
    <dbReference type="OrthoDB" id="1432388at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01830">
        <property type="entry name" value="Hydro_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="DUF1445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="SSF160920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="27357" checksum="49189631D0930A67" modified="2014-06-11" version="1">MSAAGELRSEFRGGLVRPTAGLAPGMAQANLIALPRDWAWDMLLYAQRNPRPCPVLDVGDPGSPSTVLAPGADLRTDLPLYRVWRDGELVREVGDATEAWRDDLVAFLIGCSFTFEAPLLAAGIDVRHVSAGCNVPMYRTDRPCRPAGRLRGELVVSMRPVPADRIADAVRISGRFPAVHGAPVHIGDPAALGIEDLGRPDFGDPVEVRPGELPVFWACGVTPQAAVMASAVPYAVTHAPGHMFVTDVPDHEYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSI8</accession>
    <name>A0A010ZSI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851073.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2739"/>
    <dbReference type="HOGENOM" id="CLU_181321_1_0_11"/>
    <dbReference type="OrthoDB" id="2067093at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="73" mass="8121" checksum="2F0C9C627D5D9C11" modified="2014-06-11" version="1">MSTNPFDDENGLFSVLVNDEDQHSLWPTFAAVPDGWRVVFGADGGASRADCLAYVEENWTDLRPRSLRESMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSR1</accession>
    <name>A0A010ZSR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2815"/>
    <dbReference type="HOGENOM" id="CLU_138344_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="14267" checksum="BA6C9E0DE0B4E8A0" modified="2014-06-11" version="1">MGSTLDENRARRVVDALRDRGVDAYPAKVSVYQFGVGVNLSEKRQAIWDSDGTAGLEAQVMRNGVLVGFVPTIEGSEFFDEEQTIDAIVRTDYDQPIARRLATAPPQAPPLPRSGGVFRRFFDGFRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSW8</accession>
    <name>A0A010ZSW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2851"/>
    <dbReference type="HOGENOM" id="CLU_013748_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="408"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="619" mass="65698" checksum="24079B411C800A92" modified="2014-06-11" version="1">MKLTVAQATVRFLAAQYSERDGVRQRLIAGCLGIFGHGNVAGLGQALLQDPDLLPYVLGRNEQAMVHTAVAYARMKDRLQTYAVSTSIGPGATNMITGAALATVNRLPVLLLPADTFADRSAAPLLQELEVPWSGDVTVNDAFRPVSKYFDRVHRPEQLPAALLAAMRVLTDPAETGAVTICLPQDVQAQAFDWPDEFFADRVWRVARPVPEPGDLAEAGALIRSARRPLIVAGGGVGYSGAHAALARFCESTGIPVGLTQAGKGALPFDHEQCLGAIGSTGTAAANTIAAEADLVIGVGTRYSDFTTASRTAFGADGVRFVNVNVAGLDAVKHAGLAVRADARTTLEALAGLEYTVAPEYRAEYTRLDAEWNARVRAAYDTEELTQSAVIGAVNDLSDPRDVVVCAAGSMPGDLHKLWQTRDAKGYHVEYGYSCMGYEIAGGLGVALACPDRDVFVLVGDGSYLMMATELVTALQEDLKVIVVLVQNHGFASIGALSESLGSQRFGTRYRYRTKSGRLDGDLLPVDLAANAASLGVPVVRVEDRAALADAIAAAKASATSTLIHVETDPFHNGAPDTGAWWDVPVSEVSTLDSTQAAYRTYAEHKATQRTYLHPTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT48</accession>
    <name>A0A010ZT48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569873.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038663_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="16"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="476" mass="51907" checksum="B7D2816F13672E3F" modified="2014-06-11" version="1">MTVRQPSKAPPRDRNRYFDVLRAACIAYVVLYHMFPLAVFSYWPRMGLLFAIAGSLTARSLDTSTRRAVGRRLRRLLVPLWATAALAVPVMVGFGWRPEARWELLFWVVPFSDPPGADWAGALTEPLWYLRTYLWLLLLSPLLLPLFRRFPRMTVLVPATVAVAIGTGLFDVWTLGERFGAVVRDASIYLPCWLLGFAHRDEWIAHARRVTVLVAGSVLAVAGVVWAFTHPASGSVDLNLIPLAQLLFSAGTVLLLLRPAPAWAGLERRWWPYLPANWLVMIVNRRAMVIYLWHNVALALSFPIGSALGVWGLGTAAGTAACFVLALVLVGLGVVAFGWIEDVSADRRPTLLPRLPAEPPLSSLRGPVRTRPPTGAPPAATDGVTDAVTAPDPETTVPDAVGGDDPATRAPEPADPWALRLLRADQFPAEESRPVRIVHAVGIAGGEVRVAPTTLLVREVAWSAFPGQDAPVRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT87</accession>
    <name>A0A010ZT87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849297.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1474"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23454" checksum="AB22FEEBDD0F9682" modified="2014-06-11" version="1">MRIVLAEDSVLLREGLVGLLTRYGHEVVAAVGDAPGLAEAVRTKDPDLVVTDVRMPPTHTDDGLRVAVLLRSERPNLPILVLSQYVEQTYAAELLDTADGAGVGYLLKDRVGDVDDFADAVTRVASGGTVVDQEVIRQLLRRRSNPLDRLTGREEEVLGLMAEGRSNAAIARKLVVTEAAVTKHIGNILAKLDLPIDADDHRRVLAVLAYLRRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTE8</accession>
    <name>A0A010ZTE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin biosynthesis docking scaffold, SagD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849420.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1553"/>
    <dbReference type="HOGENOM" id="CLU_020793_2_0_11"/>
    <dbReference type="OrthoDB" id="735222at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="61"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="47302" checksum="F9E82F7ED559F7DB" modified="2014-06-11" version="1">MNSRIDPRVVAALVDERTGILRRVERRPVPAHVPRSFTLVRSVIADSSAFSDWVSDTAGAGYTFGDPDAALAAAVGEGIERYCAHLIPPGLRVARHRDVDGDAIDPATIALYSRDQYAQPGFPFAPLDADTVTEWADGADLLDRRPMAVPAALVWPGHHRLADRPLAPVLQAGLAAGPTRQIAEQHALAEVIERDAMTLGWTGRAGLRPVEPPPWLSRLARGPHRRLEASFLAFPNEFDVPVIGALLSDPETGRLGLGTGCRSGPVAAALKALGEALQLLLLLGEYDDPAGPFAAAARHPTSPLSPWRADRSYLAQRRDDLRDVVDYGAHLQLALDPAYQKRFADELAEAVRDRTPWALPDEDTGDTPDLVRRSAERGHRPVSVDLTTPDVRSAGLTVVRVVVPGLYGNAAAGLPFLGGERMRRALNGRPYRALPLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTJ8</accession>
    <name>A0A010ZTJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative iron-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A010ZTJ8"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1597"/>
    <dbReference type="HOGENOM" id="CLU_031962_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="494" mass="53581" checksum="D4864ED6DACC6886" modified="2014-06-11" version="1">MTINADPPRDDVKSTALADPPVEVPAPAVKRPARWALLRRLHFYAGVFVAPFLFIAALTGLAYTLAPQLNDVVYGHELYVDRVGDTTVPLADQVAAARKAHPDGTLSTVSVLDDPEATTQIAFSVPELSADEKVHTVYVDPYTGEVRGQLTTWYNATPLQTWLDGFHRTLNLGDTGRMYSELAASWLWVISLGGLVLWIGRKRAYRGERAARRRALMPDLTAKGVRRTRGWHASIGVWIVVGLLFLSATGLTWSQYAGARFGAALDAVQGHAPALNTALGESDAAPAGGHHGGGAPTGERETDLPAGRTLEEVLAAAGPMDGRRDITIPADAGTAYSVAQDKPNWPVSFDQVAVDPVSGEVTERVAYAEWPFLAKLTKIGIRAHMGELFGVVNQVLLAALALGLLCVIVWGYRMWWQRRPTRADRKAPLGSAPPRGGWRTLPRWFLVVGIPVTLFVAWAMPLLGVTLGAFLVFDLLVGAFRWALRTPAPNLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTM9</accession>
    <name>A0A010ZTM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049704_1_1_11"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="36360" checksum="D88ED98634BBD1AD" modified="2014-06-11" version="1">MVTDDTAFAFDTDQVTPRDRVDAFRALLVDATAPSTIVLDSSSGGSPFSAKIQSWGLGAVQVLHNRASFRHEFLRTPRQVNSGAHPVISLAFRGNAGGRRSQFGVERAVSPSTLSLLDLSEPYRFSVAPDNNGHALHVPTEALDLPPAIVRRAALRLERSPLYDLMLTHVISIGRDHRLAADAEVSAAVGRSTIALTRALLMSAADRADEPSSLVVQVRAYVSHHFTDPGIGPARIAAALNVSVRHLHQTCARESVSIEQLIIRSRLRAARTALADPGRRREPIAALAQSFGFRNPAHFSRRFRTEYGVTPSQWRAENHWRAENQSASGVSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTQ4</accession>
    <name>A0A010ZTQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570319.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3179"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31394" checksum="5824EC425607CCF3" modified="2014-06-11" version="1">MDLDALRYVVTLAEELHFGRAAAEHFVAAGHFGRRVQRLERELGVRLFERTSRRVTLTPEGARVVAHARTVLAEVAELRSAAEIVRDTDESVLRVGVLGFGMADRWPALRALLRAVVPGVRLVHEELDLWNQYDAVRRGDIDVGLVHYLGDLDGLVFEPVLTSPSVVVVPVASALADAPRLTRDDVADAGWITLSGAHPRMADWAGPASHGPRRAPAVRTPGGIPSAVATSGLLGLHGGAAARYYARPDVRFVPFDGAPVEVAAVLRDSDDRPIVQAFRRAAAAVAAVAARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTR5</accession>
    <name>A0A010ZTR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849565.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_11"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="32058" checksum="FAA5BC3E63ACC36C" modified="2014-06-11" version="1">MLIAERRSRILAHVRARGYASFREIAEVVGISESTVRRDLQAMVAEGLVNAVRGGVGRAETDPAPESTRPESTRPEYARTQSARTQSARSENQSPENARSESARPAVGTAPAATLADDGRAGERSAIARYASHLVTDGSAILLGPGRSTLELARRLTGVGSLTVVTNSVPVTTVLLEHEHVELVMVGGTLRRSIQAFVGPLTEQGLQGLRGAQVFLSGDGVTAERGLTTPNVFAAAADIAFAAAGKQVVVLADHTKIGQETMCQTVPSDRIDTLVTTPGADPAALEDLRAAGVDVVVVPLVESIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUK9</accession>
    <name>A0A010ZUK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, ICC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1941"/>
    <dbReference type="HOGENOM" id="CLU_1034119_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="28908" checksum="9F210878E8AB1EDD" modified="2014-06-11" version="1">MVSDVHGRADALATAGDGADGLLVLGDLLLYLDYADPSQGILADLLGAQAGAEFAALRKEHRFGDLRSIGAQLSQVDDLPGAVTEAARQQYAELFGIMPTPAYCTYGNVDMPALWPEFVDDKHRMFDAEVVEIGGWRFGFVGGWPRKLLPAAQPVTRAPRIPPIPFGADFSPEEFAAKVESLGPVDVLCSHVPPAVPELRWDTVTRRPEVASEALLEAIHTHQPRYALFGHVHQPLQRRLRIGRTECVNVGHFRATGQPFVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUP3</accession>
    <name>A0A010ZUP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852198.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3558"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_11"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="26631" checksum="F95DD5C9BC9C8732" modified="2014-06-11" version="1">MTLSIQLVDGTIGVVTMDYPPVNAVPVAGWSAIADAMRSLGDDPTVHVVVLRAEGRGFNAGVDIKEMQRTTGFDALIGANKGCYAAFKAIYECPVPVIASVHGFCLGGGVGLVGTCDTLVASEDAYFGVPEVDRGALGAATHLSRLVPQQLMRTMYFTGRTIPAAELQRHGSVLDVVPRDKLQDATLEVAREIAAKDTRVIRAAKEALNGIEPVDVNRSYRFEQGFTFELNLAGVADEHRDAFVRDGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVP5</accession>
    <name>A0A010ZVP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850531.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="33028" checksum="84B2DF7873243F12" modified="2014-06-11" version="1">MPAITARGLRKSYAGRTVVDGIDLDINEGEIFAVLGHNGAGKTTTVEMISGVRHRDGGEVNVLGLDPDRDAEKLSHLVGVQLQDSQLPDKMRVSEAIELYSSFYRNPVDGGDLLERLHLTEHRNRPFAKLSGGQKQRLAIALALVGRPRVAVLDELTTGLDPKARRETWGLIEGLRDDGVTVVLVTHFMEEAEFLADRLALFENGKIVTVDTPAGLINQRTDGRQEIKFRLDEDPRDVMDDFRALADVRTVQVQGQNMIITGTGDVILAVTAHIARAGLTARDLRVHQATLDDALLTSGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVQ5</accession>
    <name>A0A010ZVQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850547.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2350"/>
    <dbReference type="HOGENOM" id="CLU_106204_0_0_11"/>
    <dbReference type="OrthoDB" id="1801479at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25018" checksum="A39DBC0CCDB9101C" modified="2014-06-11" version="1">MAAQPDDALRAHFTDAAIPESAAADLVRLVHGVLPQPEDAESADAATILSALRMLRALRVELADWEPRLIDAARTLGVSWNDLAPALGVASRQAAERRYLRLRPARPDEAGDTRDQRVQNERDRRAEDRAVLDWARRHAVALRRIAARVAELSDPPETARRNVEVVRRTLGEDDPAALLAPLRDARETLGESHPDLARSIDELIDRTDAVRGSTREHRNADHGGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVY3</accession>
    <name>A0A010ZVY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">CryarDRAFT_2483</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850674.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2446"/>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_11"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="414"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="737"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EXG81372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="831" mass="87591" checksum="2FE82F5F442607F5" modified="2014-06-11" version="1">MRVAVSWLGEYLDLSGRSAEEIDTAFVRAGLEVEAVHRPGAEISGPLVIGRVLSAEELTGFKKPIWYCRVDVGPEHNGDEGSRGIVCGAPNVATAEYVVASLPGAVLPGGFAIAARKTYGQVSDGMICSGRELGISDDHSGIIALSAAELPAGVEPGSDAAPVLGLDDVIFELAITPDRGYCFSVRGLARELASSLGVPFRDPASLVSVPAASGEVPHPVVVEDTVGCDRFYARAVRGLNPAAPSPLWMKRRLQAAGVRSISLAVDVTNYLMLELGQPMHAFDRARVTGPIVVRRGRPGERVTTLDGVDRAVSTEDLLITDDTGAIGLAAVMGGETTEIGPDTTVVLIEAAHWDPVTVARTARRHKLPSEASKRFERGVDPEMTAVAAEAAVRLLVEYGGAVADPGVLDLDARAAVEPIRLPVGLATRVVGVEYSRSVVERRLRDVGCTVTTGGEDELWVLPASWRPDLTDPIDLVEEVARLEGYDNIPSILPPTPSSPGLTDDQRRRRTVARALAEAGYVEVLSYPFVSPSIHDAFGLEADDPRRAAVRLANPLSDAEPEMRTSLLPGLLKAAQRNIGRGQRDVALYELGLVFSASGAGPAPRLGVDRRPTDEELAALYAAVPSQPRHVAVVLAGDRDPAGWWGAGRPASWADAIESARLVAAAAGVALTVRRGELAPWHPGRCAELVVDGQVVGHAGELHPRVVTALELPPRTAAMELDLSALPAPRVATAPVISPFPPALLDVALVVAESVPSAEVEKALVEGAGELLESVRLFDVYTGAQVGEGRKSLAFALTFRAADRTLTVEEATTSRDAAITQATTTHGASLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWJ8</accession>
    <name>A0A010ZWJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850969.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2676"/>
    <dbReference type="HOGENOM" id="CLU_087283_0_0_11"/>
    <dbReference type="OrthoDB" id="1564644at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032349">
        <property type="entry name" value="DUF4865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16157">
        <property type="entry name" value="DUF4865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="171" mass="19106" checksum="D177282F03CD1004" modified="2014-06-11" version="1">MHAMQYEIPLPTDYDMGIIRRRVATRGAALDHFPGLGLKAYLIREHAYAPFYLWNDMSGMNTFLWGGGFANIIRDFGRPPVRQWTGLAFARGPASEARTATRLDVHLPDGDPSDVIRRAIDELVPGPDVHSAALVIDTHHWVLTRFTLGGTHPGTRYEVLHLSTPGLDEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX92</accession>
    <name>A0A010ZX92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative homoserine kinase type II (Protein kinase fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2928"/>
    <dbReference type="HOGENOM" id="CLU_066396_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29951" checksum="9E3B695DEAC444FA" modified="2014-06-11" version="1">MTATYTAGGPGGSGPSAPSFLQDDPHRPVVRIGDTVRRPLHAWSATVHELLLHLEAVGFPYSPRFLGIDADGREVLTYLDGESGGAAWHRVVADAGLVAMARLLREYHDAVRDFRPAAPAGWAADDGTFEVGELVCHGDFGPWNLVWRGDRPIGILDWDYVYPGPPVHDVAYALEYVAPFRDDRYSCESLHHPVPPDRRRRLETFAGGYGLTTVDGLVDEVIEQQRNVWRRARQLAAEGRQPQLAWQESGVLDLAGERLAWSRANRHLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXD8</accession>
    <name>A0A010ZXD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851354.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2972"/>
    <dbReference type="HOGENOM" id="CLU_130902_1_0_11"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14608" checksum="57ED244F4AEC3EB6" modified="2014-06-11" version="1">MKYLILMYGSQRDYDLMTSAAPDDFAPMHAFMEQFTKDLMESGEFVDTRGLDAPVHTRRVGQKDGVPIVTDGPYAETQEVLAGYWVVDCESFDRATRIAGRLAACPSPNDVFADGYCDVRPILDHAPEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYX8</accession>
    <name>A0A010ZYX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852205.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="196" mass="21189" checksum="9585C6D7219A416E" modified="2014-06-11" version="1">MGTDPDASVDPRVARTHRDVVRTAADLLMSGGWDTVTHAEVARRAGYSKATLYAHWPTRLDLIRDAVTQICDEARHPEPGGDLRTDLVTGLTDFAQDLTGRLARVLGGVIERSGTDPVVEELRRLLYDTGTRMLRTVLETHLDARDVDPVLALLAGGIFVRIAFEGLVATPELIEDLVVRALASVQLPAGSDGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB78</accession>
    <name>A0A011AB78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.264"/>
    <dbReference type="HOGENOM" id="CLU_048478_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26426" checksum="4E13D00E74ABC99E" modified="2014-06-11" version="1">MTLPDWVPSWATLVRADNPSPMTLEGTNTWVLRAAGSTGCVVIDPGPLLEPHLEKVAGYGPVVATLLTHGHPDHAEGAARFAEMTGSDVLALDPRHGQPLVPDGEPLEVAGLSLRTFGTPGHTADSVSFVIDDEAVLTGDTILGRGTTVVAWPDGILGDYLTSLERLRGLGNIPVLPGHGPVLPDAQAVAAYYLEHRAQRLAQVEAAVTAGASTPMQVVEAVYADVDRSVWPAAELSVRAQLDYLRATGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB91</accession>
    <name>A0A011AB91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="12" type="ORF">CryarDRAFT_0282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.269"/>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="243" mass="26647" checksum="96DCF9539E683736" modified="2014-06-11" version="1">MTVAVESPLALKRRARRMHRILTETHPDAHCELDFTTPLELAVATILSAQTTDVRVNLTTPTLFAKYRTAEDYAGADRTEMETILKPTGFFRAKTNSLIGLGQALVERFDGELPHTLGELVTLPGIGRKTANVVLGNAFDVPGITVDTHFGRLVRRFGWTAEEDPVKVEHIVGDLFPRKDWTMLSHRLIFHGRRVCHARKPACGACTLKALCPSYGTGPTDLPAAVKLLKGPRVDELAAMVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABJ5</accession>
    <name>A0A011ABJ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">CryarDRAFT_0426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847995.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.410"/>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_11"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="26859" checksum="D10AB1ABB7A3667E" modified="2014-06-11" version="1">MLLTIDVGNTNIVLATFSGEKLVHSWRVRTDSRMTADELALLFRGLLESEAVQITGVSACSTVPATLRELRAMLDRYYGDIPTMIIEPGVRTGVSIVMDNPKEVGSDRIMNTLATYHLFGGPAVVVDFGTSTNFDVVGPDGAFMGGALAPGIDISVDALAARAAQLRKVELVRPRSVIGKNTVEALQSGIIYGFAGQVDGIARRMVEELGGASAVVATGGLAPLVIGESREITHHEPNLTLIGLRLAFDRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABN9</accession>
    <name>A0A011ABN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methylhydantoinase B/acetone carboxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848090.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.460"/>
    <dbReference type="HOGENOM" id="CLU_020413_1_0_11"/>
    <dbReference type="OrthoDB" id="1018930at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="4"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="613" mass="65850" checksum="6EC2BA6A2F8DBF33" modified="2014-06-11" version="1">MSVDPIVLEIVEGTLAAIELEVETAIGRTARSPMIRDAHDFRAGIHDRKLRKLTGRSYSALVQPVARDYPLDSMKPGDVFFHNDVYLSEGGIGHLPDLCVTVPVFHDGSVVAFVQAFGHHDDIGGAVPGSMPSAATSVFEEGLMVPPIRLWDAGVPNEAALKIMTRNSRMPDSLAADLDAECSACLMGAQRLGELFARYGRSTVEACFDAILANTTRVFQQELLSKIPDGSYVWEDYAEHDGVDEPKLHAQRITLTKVSAGDGVTDGKLILDFTGTSPQAKGPINHCANYSDGNFLAKWLAPILRNLADSPERMAELDVNEGVIPLIEMKFPPPGTLLTPIFPAPTNARTFVILRLLGVLAGVVAKAVDGRMPADQETIRYTGVYGTDFEGQPYLMREVLGGGSGGRYYADGEDTIHVVPDSRNIPVEFAEARWPFVVESLGLAVDSGGAGRYRGGLGYEKHIRMLRDASFMSIADRALLACWGVRGGRAGRPFEVVIDPGGPGERVVDALADSEPVRAGEVIRIRTTGGGGWGDPFERPYDEVARDLEWGKVSVAGARNDYGVVLGSDGSIDVEASDALRASRTSSSEAFFDRGPGFPALAGGRTHADVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABW8</accession>
    <name>A0A011ABW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848253.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.554"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_2_11"/>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="453" mass="50727" checksum="D23E5FE5A2368EF6" modified="2014-06-11" version="1">MPNTVFWFRRDLRLIDNPALLEAVSAAGDDGVRALFVLDPVPFRASGGPRTSHLARSLRALDDALGGALLIRHGDPVTEVPRAAAEIDADEVYIAADYGPYGSRRDQRVEKALLDAGATLHRTGSPYAVAPGRVRKPDGTPYRVFTPFSKAWRTHGWRGPVDAPKKVSWLPAKDGDGFPDVPDLPDVELPEAGEDAARERLAAFLDEKVRHYKSDRNRPDHDGTSRLSVHLKYGELHPRTILAELAKHRGEGADTFRNEICWRDFYADVMFHRPESVWESLDQRVGSIETDSGKQADERFEAWAAGRTGFPIVDAGMRQLLSVGWMHNRVRMITASFLVKDLHLPWQRGAAHFLDLLVDGDYASNNHGWQWVAGTGTDAAPYIRVFNPVTQGKKFDPDGGYVRRWVPELAEVSGAAVHEPWTLETQPEGYPEPIVDHAAERKETLDRFERVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACS3</accession>
    <name>A0A011ACS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.876"/>
    <dbReference type="HOGENOM" id="CLU_066193_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="27450" checksum="EB9B9B1C0943C549" modified="2014-06-11" version="1">MDRRGQRGGWADFQTHSFGSPSAELAPFVEHYWAVRWDLRGQEPFRQLLPPHVNVHLSYVGSSPGAVRGPARRFSHRALSDVGEVFGVAFRPGAFRPFLDGPVSSLAGRSVAAAAIFGRDGAPTPDAVESLLLAREPVLTAAATSARDAVELIASEPALTRVEALAARLDVGVRSLQRLFAEHVGLGPKWCIRRYRLAEVTSRLESGADVDWAALAAELGYADQAHLSRDFTAILGEPPSRYALRYPSGSPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD92</accession>
    <name>A0A011AD92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848783.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417819_0_0_11"/>
    <dbReference type="OrthoDB" id="424954at201174"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="656" mass="65877" checksum="F1AD601B629C8CF1" modified="2014-06-11" version="1">MAEKLVFDVLARASGTSDVKRLGDALDGVGKSADNLDKKKSIGGGLFKGLAGEAETAGKSVTSKLGSAFSNLASNAAEAGKKAGSTLASGISSGFEALGPGGPYAGGAIFAGLLAAAPVAGAAIGGALIAGVASAGIGAGIALALQDPEIKGAASVLGGDIVDALTEAAEPFKGALLATFSTVGEGFKASLGDIKATFSNLAPMLEPLAAKTSEAFASITRGVAVLSSTAGPVMTALGNGIAQIGETLGTGFAMLSQNGAAAATGLQMAFSGLNAILQAGFGLVNGLTEAFGWLAQKGLLGEDVKQSYEGFKEQLDATKNSVTGLGSSFDAVTPAQQLAIDQVKLLTGSFAEATNAAGGLKGALDTLNGSAIAGVQSEVAYQAALDGVTNSVKSHGTSLDTATEAGRANTTALTQAITTAQNYASANDLSATQVEALRQSILQQADAAGLDTKTVTGLINELFRVPGDVKSKVSVPGATLSTEQVKALQNALTSLPDEVRTKVITEHLDIFNATGSTNAAAAKDKSLRRWGGIDKMMAAGGVVQAHTVSSPTIMYGERATKEEAYVPKNGITSRSREILDKAAAWYGGRVSWGAQNTGGSPGGGTSGGDQLSLLVRELIGEVRGMRREQGQGNVYLDGRLVGAVQGRELSLYERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADB1</accession>
    <name>A0A011ADB1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1088"/>
    <dbReference type="HOGENOM" id="CLU_116587_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16348" checksum="5A8968BD74D9922E" modified="2014-06-11" version="1">MGERGAATVEFVFAGVLLLVPLLYLAIALSEVQRNAFAVTQAAREAGRAYATAEDPATAPARAGYAVRLALADQDLSGTAELRWGPVGRSCDGLTVDSTVSSVNQPPSQPGARFELCVRRTYRLPGVPTFLDARRNTIEARFVVQVDDLRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADP3</accession>
    <name>A0A011ADP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein, possibly involved in utilization of glycolate and propanediol</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848975.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1223"/>
    <dbReference type="HOGENOM" id="CLU_103773_2_0_11"/>
    <dbReference type="OrthoDB" id="1551899at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="14163" checksum="2E77D9487AF6C17A" modified="2014-06-11" version="1">MTNGPDLDTALMLCATALATARDIGAFVSVAVVDGGGNLVAFVRMDGAEIAGPTLAVDKAYTAVAHRVSTDVLGVLAGPGGPLQGLASAAGGRYVCFGGGKPLWMEGRVVGGVGVSGGTVEQDVACVKAAADKWPHTAPAESAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH12</accession>
    <name>A0A011AH12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850554.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2354"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29120" checksum="19E248788D55A2F0" modified="2014-06-11" version="1">MGQLDGKVAFITGAARGQGRSHALTLAREGADIIAIDLCAQAETVPYPMATPEDLAETVKEVEALDRRIIAAQVDVRDLAGLKAAVDQGVAELGRLDIVLANAGISTPAPTLEMDETVWDEMIEINLTGVWKTVKASVPHIQAGGRGGAVVITSSLAATWVNANTAHYSAAKAGIVMLAKVMAKELAPESIRVNTVHPTTVATGMILNDPTYRLFRPDLENPTREDFDVAAKELNKLPVVALDPSDISNAILYLVADTGRYITGTTHYVDAGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHK2</accession>
    <name>A0A011AHK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribA</name>
        <name evidence="7" type="ORF">CryarDRAFT_2616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2579"/>
    <dbReference type="HOGENOM" id="CLU_020273_2_1_11"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="22986" checksum="0B2525E53432EA6D" modified="2014-06-11" version="1">MTATAPATVRVLARAKLPTRHGVFDAVCFSGADDVEHLALSMRTPPAAPPDPEPPLIRVHSECLTGEALGSQRCDCGPQLDTALALIAEEGRGMVLYLRGHEGRGIGLAQKIRAYALQEAGLDTVEANLELGEPVDRRSYGPAAAYLRQIGVEQVRLLTNNPDKVAALRAAGIGIAEVHAMPAAPLPANEAYLATKTQKMGHRGLRPGEEPLSYSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKN1</accession>
    <name>A0A011AKN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852399.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541551_0_0_11"/>
    <dbReference type="OrthoDB" id="2060303at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="503" mass="56424" checksum="4F4C5FF6130C1D9C" modified="2014-06-11" version="1">MDDRRGAAELGSALRAASPVELYRFNAFRVTGLPVDATPAEVRRSASQLRAAHALGVDAQLPGQVLPLTPAPSHELVEQALARLRDPISQVVDMFFWFWPGNDAATAALAAGDLDGAERAWDADGSAAASHNLAVLNHLLALDAEHVGKTPPRYGAAARWRETYRHWLAAWRDDAVWVEFADRVMGLRHPGLDATVAATVRDLVPTVVMAGTAAVALRGADRGWDDERIRVHWRLVHRPGFPDDTRAVVVRAATDQIVERLEVRLEKAEQDLSHHPERADELSERLAEATHPLLVNLELARTADSDALHDGVARLLLRCAYTGHQHLGDWERTRTMLRRAQRPARGEMIRTQVREDILAVERMLENPRRPEARGYTYRVPTQDELEASAEAERQRNIEIILEELRKVPNLLTEEREAEVRRLGASLGALGGIVFVRSSTWVDNPIEVARRYREIFAGRDHLAKVRREAQGRRSLLDELRREADEAKTRRYFDLEGGRPGDVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL80</accession>
    <name>A0A011AL80_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852637.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3870"/>
    <dbReference type="HOGENOM" id="CLU_1010898_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="30060" checksum="CE6D22DD01E7D750" modified="2014-06-11" version="1">MPYLDVSGTKLWYDEHGTGTDVVLSCAMGFSGYPAVLADPPIGARVFALQARGFGRSDHQSQPPEQGWLDQWGDDVLALADHVGAERFVYTGVSHGAGIGWHLARRAPERLRALISVVGTPHDRNGDTSSSAGRRSVIENRGNLAEIERQFRRLGGETDTPGRAAIRDRTIAAILRRQESFTDDEARINQGMPFPEATTNDAVAAILRGIDLPVLILAGMRDGVISPESTLRAARSVPRAKAVLFEDEGHFVAEERPERLVREIAVFLDELEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALP4</accession>
    <name>A0A011ALP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4025"/>
    <dbReference type="HOGENOM" id="CLU_539376_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="248"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="428"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="490" mass="51824" checksum="B3325D24595E4BDC" modified="2014-06-11" version="1">MAQLTVLDLLGHGERLGLSHSAGPADERTVARVDVTPLDLLSTMPADTLVIVPGEAHPAPYRLDVALRQASARRLAGLVFTTALALPETAVALAKRGGVPVFAAPGTKPADLALAVDRLLSGGAPEAIMRATHGIEKATEAAARNDCTPESILAAANRALGAELRLVEDASVPWSAADAVCVGEVPIGRLVGASDPASALALPVIASLLSRVAQRRITDRFAPTQSRADLIVELVLAESSRVEGFVGQAARLGLPLQLSHVAAWLIPVGLANPEARAPRSLQPALELFALQLVDGRDEMWHVAFVQDDLILVSTEDHGAGDHQRRLRGVAERIQEYARSLAGDGWEYTLGLGTPQSGATGLRSSAAEARIAAESAIAAGRFGGVELTDVTGLRRVLLDVYASPTSRSLLTDILHPLDALGPERAHTAVQTLLAYLAHRNSLAHAGRELNLHPNAVGYRLKRVREVLHLDLDDPDTRFAVELACRVRLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFU6</accession>
    <name>A0A010YFU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative threonine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.112"/>
    <dbReference type="HOGENOM" id="CLU_079569_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="21347" checksum="4568901BE37140B6" modified="2014-06-11" version="1">MSHLAAFAVTALIIIVIPGPSVLFVVGRSLSLGRRGGLMSVLGNTLGMLPQIAAVSLGVGAVVAESVLLFQLLKLAGAGYLVYLGVQAIRHRNDVTTAEPTAPQPTGRLIRQGFLVGVTNPKSIVLFAAVLPQFTDHAVGSVPLQIAVLGLMVVAIGTVNDTLWAVAAATARQWFARSKERISRLGAAGGVMMIGLGATLAFTGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG10</accession>
    <name>A0A010YG10_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.180"/>
    <dbReference type="HOGENOM" id="CLU_144206_1_0_11"/>
    <dbReference type="OrthoDB" id="1814076at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14931" checksum="DE2DD400ACB4D832" modified="2014-06-11" version="1">MSRIRAEYMDPAGVRHGGLPTAHWGGADPTVYATRRQLAKDRLQPNRQPIAAQILWWGITGYGGYGTRVAYLYRRDLAAPKRPATPAQLAALEKANRARRTCSTCEQVKPYVIPRSLGECIDCHDAPWIEQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGZ9</accession>
    <name>A0A010YGZ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.578"/>
    <dbReference type="HOGENOM" id="CLU_048268_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458795" description="Phytase-like domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="406" mass="43564" checksum="1AE9E3ECBE8C2C2A" modified="2014-06-11" version="1">MQPWCRFLSLAVPVTAALALTAVPATAHSDAVTLLGRAAISATDYQPGPDSGTALDKTTVNGITPPFTGQPIPGFSAAITASAGDESGRRLLAMPDNGFGAKNNSADFLLRAYYVEPDYRHGDVKIDGFVSFRDPDHKVPFDIVNKNTKDRLLTGADFDIESLQRDAHGNLWIGDEFGPYLIEVDRTGKVLQAPIPLADGTRSPQSPDLKAGETPSLAASNGFEAMAVSTDGKTLYPILEGPKVADTDKTRRVVYEFSIRENKYTGRTWSIDVGAVGQLVADAQVLDGHRIAWLERDNFEGAEAKVKRIHIADLDKADKSGAVKSTTIADLLTIADPRGISSPAREGEFGVGPTFAFPFQSVETILPLHGDTVFVTNDNNFPSNDGRITGKADDIELIEISIPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH65</accession>
    <name>A0A010YH65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848380.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.647"/>
    <dbReference type="HOGENOM" id="CLU_083287_15_6_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="148" mass="15465" checksum="730737B212DE8138" modified="2014-06-11" version="1">MAATPGAVADELSALLGRLHRTLRRAARSDQPDEPLPSAQMEVLRVVLAQPGIGVKAVAAVLGTAPNTVSTLVGDLTSGGYLDRTPDPQNRRAVRLTLTPSAGELIDGYTDRRRRIAISAADQLDQADVEALAAALPALNRLLVLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHB2</accession>
    <name>A0A010YHB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848443.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.694"/>
    <dbReference type="HOGENOM" id="CLU_114403_0_0_11"/>
    <dbReference type="OrthoDB" id="1656455at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="15940" checksum="4A69F4E9D9F07E49" modified="2014-06-11" version="1">MKLTPRWRKTVLISHVATSVGWLGADAVLVVLGVAGLTGAAGGPDVVYPVAGLIGTVLITPLALAALVTGVVSGLGTKWGLVRYWWVAVKLAVTVVMNVLVLFLLAPGLREAARLGAELPSRDAINLVVAPSVACALLLFTTVLSVAKPWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ77</accession>
    <name>A0A010YJ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849063.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1295"/>
    <dbReference type="HOGENOM" id="CLU_040681_3_2_11"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15709" checksum="F88D45961397849E" modified="2014-06-11" version="1">MLISDVLRSKSSGSEVATVRPDESVRALLARLAEHNFGALIVSNDGETIAGIVSERDIVRRLHEHGARLLDESVSSIMTVDVHTCHSTDDVAHVRGTMTDRRIRHLPVVDEGRLVGLVSIGDVVKSTISELETEKEQLVGYITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJW5</accession>
    <name>A0A010YJW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849475.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052584_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="29036" checksum="E6EF411F1826BDD8" modified="2014-06-11" version="1">MTSPLEDHLAAGMREVAAGYHVDRDLIAGARTAQRRRTRHRRAVVSAAAVAVLAIGGAGYALAEPGGSSTDRLTSAAPPLDRTLRTKGPYILHITTYSDGEQGEQKTEIWRDPVTDDQVEIDGGGPGIDIGYNMRTSMTAICVDRNERTWWSCRPEQNSIPLATPENMRAWLKTETTLRAVGRETINGVDTVHLAKPRTAGRAFDVWVTADTDVLVRQRSSGEYEPGSGVVTIQTDYEWFDRTPEARARVTLSPPSDWPSRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKC5</accession>
    <name>A0A010YKC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein, possibly involved in aromatic compounds catabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849702.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1740"/>
    <dbReference type="HOGENOM" id="CLU_089876_6_3_11"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="16445" checksum="B3870EC067087E44" modified="2014-06-11" version="1">MTESIQERLYPDLPCFGCGHGNDRGLKLRSYPADGYVTAQFTPWLEHDNGLGFLNGGIISTVLDCHSAAAVMLEAERQGWPPLPGVPLSYVTAGLDVRYLRPAPLKETVELRAVVTSATEPQITADVELIWDGKVRATAAALWKRWRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKZ2</accession>
    <name>A0A010YKZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850030.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1965"/>
    <dbReference type="HOGENOM" id="CLU_055111_0_0_11"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="361" mass="37755" checksum="AD1EFAAE2A08F1BB" modified="2014-06-11" version="1">MIALVGNPGSRRATMFTAAARAAGHDVEVLPWRAVAGGPVTFPSGALVRIDSPGEDAEVDRRLRGAAQPAQFGEIVGGAAWYRGFRAALERVVAAAGASGARLLHDPGDIAVMFDKRLAHARLAAAAVPVPQALPPAAPAAAEFTGAGIGGYEELRAGMRAAGWARVFVKPAHGSSASGVVALHAGDRRALAVTSVELTDRALFNSLRVRRYTSEREVAAIVDRLAPDGLHVERWFPKASLDGRVFDLRVLVVDGVPGHVVVRTSRTPMTNLHLGNARGDVRAVRARIGAEAYESALATCVRAAAGFPGSPHVGVDLMIGVDRRTHAVAEVNAFGDLLPGVLDAHGRTTYEAQLEALGARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLB9</accession>
    <name>A0A010YLB9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850175.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053665_0_1_11"/>
    <dbReference type="OrthoDB" id="1481281at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457621" evidence="2">
        <location>
            <begin position="30"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="24606" checksum="706DD23FFF9A1D16" modified="2014-06-11" version="1">MNASIRSVTTRSALAAAGLLTALALTACGSTYDGASQNTAATGKPAPATADVVPPADEVIPKTTESDDSESAAGGDAGASSADVGKKPTTLKRTRTKKMGDVVTDERGWILYRFDKDKPKPPESTCEDDCAKVWPPVVAGDQKLVGLDAAKVGEVTRKDGTKQVTLGGWPLYYYLGDKKPGDWTGQNVGKVWFAVSPDGTKNVTCLPENPPKPPTPPKDTAAQSDDADAGDSGYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMK9</accession>
    <name>A0A010YMK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2537"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="345" mass="36662" checksum="3E707E7F2FFD24EB" modified="2014-06-11" version="1">MSAPERPSERPRTSIMRDVARLAGVSHQTVSRVLNEHPSVREETRARVLEAMRALNYRRNLAARTLATRRSGILGLVGFESTLYGPASMLYGIEDAARAAGYFVSVVTVRSLERTAVLEAIDRLCAQAVEGIVAIAPKESAANALAEVPDGLGAVGVGGAGESGVASVRFDNRAGAALATQHLLDLGHATVHHVGGPSDWPEARDRIEGWRATLYANDRVVPEAEFGAWTADSGYEIGAALARDPSVTAVFCANDPVALGVLRAMHEAGRRVPDDVSVVGFDDVPEAGYFLPPLTTVRQDFAELGRRSLEVLLDQLREDAPAGRNDGSVLLEPTLTVRGSTGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMN9</accession>
    <name>A0A010YMN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="22442" checksum="9A8ACEE74E14B9BE" modified="2014-06-11" version="1">MTTKRRGKSREIARSAISVLSEHGVRNARLADIGAGLGMTGAHLLYYFESKTDLFMASLRIVESDLRERAESAFAELATAQERWRWLVDAAAPSGLRDSNLMMWLEAWSEAVHDPAVHQLITELETGWQGLVREVLEYGVETGELDADLDVETFVEGFSALLDGLTIRAVVGYRPVDKARIVEICDRFAEAHLRWNTPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNG2</accession>
    <name>A0A010YNG2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">CryarDRAFT_2829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851140.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2791"/>
    <dbReference type="HOGENOM" id="CLU_020352_0_0_11"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="361" mass="37468" checksum="647EF0EED616314D" modified="2014-06-11" version="1">MTRVLAITAGSHSVGIALFDGDEELAAETLDVDPGTAGDALRAFLGTLPAPPDVVGHRLVHGGGLVAVPTLVDDALADALSEVADLAPQHDPPALALLAAARRELPGAAHYVCPDTRFHAGLPPAAALLPLPREWRERWGLHRYGFHGLSYAWASRRAAEILDRPAPNLVIAHLGGGGSVCAVAGGRSVDTTMGMTPLDGIPMTKRSGAVDPGLLLWLLDGRLTRTELADGLQQESGLLGMSDGLSADTRELVASPDPAAAAALDAYAHAVRRAVGAMAVSLPQLDALVFTGEIGWDQPEVRAAVCAGLAILGIQPVPAEPVTSDGVISREGVPVLVVETDEERQIAREVEAADRGHSARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNR3</accession>
    <name>A0A010YNR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851252.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2887"/>
    <dbReference type="HOGENOM" id="CLU_069356_1_2_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="24916" checksum="8BB65C5FBE890A83" modified="2014-06-11" version="1">MTAAPADDVTPERQRDAERTRAEILDAATEEFASRGYAGGRVDEIAAKTRTTKRMIYYYFGSKQELYLAVLERAYAGIRRLEQELDVDHLDPARALRALAELTFDHHQSHPAFIRLVSIENIHHAEHLRTSPILPTLAAPAVDVLSGILERGRAAGLFRDDVDALDVHMVISAFCVFRTANRYTFEAIFGRDMLDAERSAQHRRMIGELLLEYLTAHVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP37</accession>
    <name>A0A010YP37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570242.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3029"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="30880" checksum="56C03EE192D3618E" modified="2014-06-11" version="1">MRAVQFAQYGPPSVLEVVEVAEPHAGPGEVRVAVRASGLSTGETLIRSGAMRAVVPAVLPWRTGFDAAGVVDEVGAGVTGVAIGDAVFGWVSPGTRGANAEIAVLVAWAPKPAGWSWDEAGGAAGSVETATRVLDRLAVGDGDTVLINGAAGGVGTVAVQLAVARGARVVGTAGVYNHEFLRALGAHPTTYGPGLTERVPPGVDAVFDCAGGALPDLIALAGDPDRVVTIADLTAPAVGVHLSSGGTDPLADHALGLAVDLAAQGRLTIPVAATFGLEEAAAAHELSEGRHAPGKIVFSGSYPPAPSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPF9</accession>
    <name>A0A010YPF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3175"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="410"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="53966" checksum="BE5B97EA7745DE26" modified="2014-06-11" version="1">MNDWLHEAATADADAAWLLCDRHDPDAVAFRVVAADLSIRSLSYGELADRSRRLATVLRSAGVEAGHRVAVLMGKRLELPVALLAIWRLGAIHVPLFTAFAPDAISARLTASGVRLAISEPGQAAKLEGVAVVSVNDELDARIRAAEPLRDRRPIGGGGQLVELYTSGTTGAPKAVPVPVRALAAFRSYLHYGLDVTEDDVYWNAADPGWAYGLYYAILGPLAHGRANLLVEGGFDPRRTLEVMNRCGVTNFAGAPTMYRALRGVGTARLRRASSAGEPLTPDVTAWAPDALGTEVRDHYGQTEQGMVILNGWHASVRSVVESGSMGRPLPGFTATVLDGQIALDVEASPLMWFEGYVDAPERTRERFTADGRYYLTGDTGRVDENGAFYFTARDDDVILAAGYRIGPFDVESVLVTHPAVADVAVVGAPDELRGEIVVAYVVLADGESPGPTFLAQLQDLVRTRYSAHAYPRQVHVVESLPKTASGKIQRFVLRRGTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRG7</accession>
    <name>A0A010YRG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570658.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_0_11"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22676" checksum="F2FAC5A45705B819" modified="2014-06-11" version="1">MPAVKGREGVRSGARRARSFDDVVDRVRGAILAGSIPAGERLPSERELAEQFGVSRATLREALRALEALGLIEIRVGAHGGAFATEGGSGRTADVLRHAFDVEFATRPRHARQYRAAAHADSVTWAVPDQERLERLRAAIERGEAAFLRALAEATGSPVRVAVAVALESGHAAGARPSLEPDDMREVLDLLQRGERDRARALLHQRLGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRL6</accession>
    <name>A0A010YRL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852850.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4024"/>
    <dbReference type="HOGENOM" id="CLU_020336_0_1_11"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="30837" checksum="9B569A045836B59E" modified="2014-06-11" version="1">MPTLTTAAGITIYYETDGDPSGRPLVLVHGGGAQLIGWPDEFVAHLVGAGFFVVRPDNRDVGLSQQTGGPDDLAATYDISDMAADVVALLDHLGIERAHLTGMSLGGYIVQLVAIEHPGRVASLGLMSTSPSSEPEFLVGTHGDGQPVTTPPERLDRDAYITMFVNGQRGWHSPGFRFDEDESRALAARYYDRVYRPDGLVRQWNAMLNGPLERREELRAVDVPTVVIHGRGDGTLHWRAATAFAEIMPQAEVLLFEGMGHDVPRELWPDFVRGIARAASRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRN8</accession>
    <name>A0A010YRN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, sugar porter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570695.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4051"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_11"/>
    <dbReference type="OrthoDB" id="955823at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="465" mass="49783" checksum="23FED6593418881D" modified="2014-06-11" version="1">MGQAVSSEQKNDRLTGSVVVVALVSAISGLLYGYDTGIISGALLQIGDDFDIGHVWEQTIAASILVGAVIGALTCSRLAERRGRHGTLLLIGIVFVVGAVAAALSPEPITLSLSRLVLGFAVGGATQTAPVYVAELAPSAYRGRLVLFFQIAIGVGIVIATIVGAAEVIDWRVSIGLAAVPAAIMFVLMLRLPESPRWLAREGHDDRAREALARVRHPEADLTRELDEIQENVRAEREASTRGWAGLKAAWVRPALVVGCGLAIFTQLSGIEMIVYYTPTILTDNGFTDSTALRVSVALGLTYLIAQLIGLAIIDRVGRRRLTLVTLPFAALSLIVLGWFFVSGNDGKSMIPWIIATLIAFMAFTAGGIQLMGWLTGSEIYPLATRAAGAAAQSASLWGTNVLITLTLLSTMKAIGTGQTFWMYAAFNIAAFVFLYVKMPELTGRSLEQIEEHLADRKFKPADFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVH3</accession>
    <name>A0A010YVH3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">CryarDRAFT_0166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847599.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.158"/>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_11"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="15133" checksum="BA64F64608F8756F" modified="2014-06-11" version="1">MRAALVVAEGASASGDVPVGAVVLDESGAELSRACNEREASGDPTAHAEVLALRRAAGARGTWRLAGCTLVVTLEPCTMCAGALVLSRVDRVVFGAWDPKAGAAGSLWDVVRDRRLNHRPEVLGGVLEDECAALLDSFFAAHRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVK5</accession>
    <name>A0A010YVK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.188"/>
    <dbReference type="HOGENOM" id="CLU_140176_14_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="75" mass="8091" checksum="7926941E4006C705" modified="2014-06-11" version="1">MTTIESAAGAVPAAPTDPVLTVEEAARYLRIGRTSMYALVSSGEVESVTIGRLRRIPRSALDDYVTRLRSARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWE6</accession>
    <name>A0A010YWE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_19_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="175" mass="19283" checksum="31EF573359C4608A" modified="2014-06-11" version="1">MFRRCNDGAVNHRVRRLRPDDWREFRRLRLEALKDSPLAFVEQYDDALALPDDAWQERAAATDRATFVAVDADDRLVGMAGIFGEEAASAMLVGVYVTPAQRGGGAAAAVIGAAVEWARAELAVDQVRLFVLDVNERAKSFYRRLGFAETGGTMRYPPDPSYLELEMAVSALSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWF6</accession>
    <name>A0A010YWF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848176.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.509"/>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="33798" checksum="36A23A4CBB5A554B" modified="2014-06-11" version="1">MSTLRWGILGTGNIARTFTSDLLTLPDHEVVAVGSRAAETAESFAAEFGIARAHGSYQALADDAGVDVVYVATPHAGHAAAALTCIAAGRHVLVEKPFTLDAAEATTVVTAARDAGVFCMEAMWTRFNPAIALLRELVDDGAIGEIVAVQADFGFAAAYDPKGRLWAPELGGGALLDLGVYPVSLASMLLGEPTTVLATAGKAATGVDANTGILLGYESGALAVLHCSLRGDTPARAEIIGTRGRIELAPLFFRATELTLHHRDAEPRHETFTLPGNGYTFQAEEVARRIRAGHTESDLMTLDETLSIARTLDRVRASFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWW6</accession>
    <name>A0A010YWW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569687.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.682"/>
    <dbReference type="HOGENOM" id="CLU_069356_18_2_11"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="203" mass="21983" checksum="804B4B5CBACE5FC9" modified="2014-06-11" version="1">MASPTDTQPARRTQADRSAATKTRLLDATITSLVEDGYNGTTTTAVAQRAGVSRGAQLHHYGTKEKLVAAAVAHLAEQRAAVVRDQIAQLGAAKDTLRRTLDLLADFLSGPLYAATIELWVAARSDAALREMLIPVEAQLAKELREICREYVTSDPLLQQMTLDLLLGRGVTMLLTDWNAGHRAQALDAWAEMLATRNAPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX36</accession>
    <name>A0A010YX36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small subunit of phenylpropionate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848484.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.744"/>
    <dbReference type="HOGENOM" id="CLU_102527_0_0_11"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="19070" checksum="2F421840F965295F" modified="2014-06-11" version="1">MSAPTITVTRADAEDFLYQEAMLLDEWHLDAWLALFEEGGTFEVPTTDYKGWDRTGGGFFVLDDWDLLNARVKRLKSRKAHAENPHSRTHRMISNVRLIQGAGGIEIKANFVINRFRDLTHHTYVGRYHHDVVQNEEGELKFVHRRAYLEHELLEHGARLSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXM9</accession>
    <name>A0A010YXM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848723.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.994"/>
    <dbReference type="HOGENOM" id="CLU_028527_0_0_11"/>
    <dbReference type="OrthoDB" id="520320at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="58679" checksum="41853FBC83A57286" modified="2014-06-11" version="1">MTREFRKTAEAVVDDLLGGDPVAAYYVGDHRTDHELPDYSADAVAERVRRLREDADALVEIDPDDLGPEDAVDVQLLASAVDERLFALTELREHEWNPLVHNPGALLDGLITREFAPPAERLEALVDRLRTIPDALATAENVLRDCPRIHVETALGQLEGTAALITDDVPRLAAEVPGFDVTAPRTAALAALDRHRAWLTDHLETAVGEARLGRRRWEAKLWHELDSELTAGALLDAAEKRLADVGEQIREAAKELTGTDDVRAALDALAADRPDDATVLARAQEGLRATIEFVREHDLVSLTDDECRVIEMPEFARGVAIAYCDAPGPLETAPLPTFYAIAPTPADWSADRRDSFYREYNDHMLRNLTVHEAVPGHFLQLSHARRFRAGTRARALCMSGSFVEGWAVYAEEMMVDAGFGGPQVRMQQLKMQLRMTINALLDQLVHAEGLAEADAMALMLDKGFQEEREAAGKWRRALLTAGQLSTYFVGYTEVSAVAAARPSDVPVKTWHDRMLAHGSPSPRHLRTLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXV6</accession>
    <name>A0A010YXV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848806.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1080"/>
    <dbReference type="HOGENOM" id="CLU_064032_0_0_11"/>
    <dbReference type="OrthoDB" id="1126926at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="120"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="292" mass="31026" checksum="BCC84596525D7E60" modified="2014-06-11" version="1">MGALLGFVFGCGAVLLLRRFPIDALRPGRGGSRAVSGWGFRPRRRELLRAAGLGEIGAVRLGAAQILAGLVAGAVAFVVTGSTSVATCFAVFGYLAPVALVRRLRAARVRALRDAWPDVVDNLASAVRAGMSLPEAVAALAERGPAPLRPAFARFAADHRATGQFLLCLDRLKDDLADPVADRICEALRVAREVGGTDLGRLLRTLSGFLRADARIRAELETRQGWTVNAARLAVAAPWLVLLLLAIQSTTLSVFDSTSGRVLLAFGGAVTVLAYRLMLRVGRLPTDRRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXW6</accession>
    <name>A0A010YXW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1089"/>
    <dbReference type="HOGENOM" id="CLU_089258_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="3">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19722" checksum="B374B94574BAE3E4" modified="2014-06-11" version="1">MANMAEKGLNATAAALLGLLHEGPMTGGQLMATAENRLGPFWTTTRSQVYRELPVLAERGFVRLGRPGPRSSQPYAITASGKRVFAKWLSEDAGRDQLRNPLMLRAAFGSLHKPQQLQELYAERREEHTARLAELREELKEIKKRDDAFQAATLEFAIQYQRSILKWLDTAPGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXZ1</accession>
    <name>A0A010YXZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848857.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="40723" checksum="0921DD0024E1EE10" modified="2014-06-11" version="1">MQPHESARGPHVLRQINSRAVLRAIRERSPARVADLMQATGLSRPAVTRAVAELRDAGLVADVDETAQVSMGRPAQWIRFRAEAGYVVGVDVGSHKVVAMVADLSGKVVASRQMATGERLLQSVRDTIAEALAKADLTGDDVWAIVVGTPGIVEESSGEVLLAPGIPGLAHLPVLDELRTITPSPVLIENDINLAVLGERWCGAAVGSDSLVFVHWGVRIGAGIIIDGKPYRGANGAAGEIGFVDVFSTPDGPDPEPLLGARAANAVSEKGAFEHAVGSQTIAELADAEDVAAVFAAATDGDPAALEVVDRIAARFARGLAALLLILDPREVIIGGGLSRAGETLLAAIDRHLRPRILTSPRLVLSDLGSDAVALGAVRRALDHAEQRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYM7</accession>
    <name>A0A010YYM7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1357"/>
    <dbReference type="HOGENOM" id="CLU_016684_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012804">
        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02442">
        <property type="entry name" value="Cob-chelat-sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="537"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="715" mass="75852" checksum="A6D8A54B33A2F70E" modified="2014-06-11" version="1">MRDRRVTPPYPFSAVVGLDDLRLALTLNAVSPAIGGVLARGEKGTAKSTVVRALHALLPPVTVVAGCRFACDPASPDPQCPDGPHADVTAESRPARLVELPVGATEDRLVGALDLERALTEGVRAYQPGLLAAAHRGVLYVDEVNLLADHLVDTLLDAAGMGRAYVERDGVSVRHAARFLLVGTMNPEEGELRPQLLDRFGLTVEVTASRDPAERAEVVRRRLAYEADPEGFAARWAEHDAELAGHIVEARARLADVVLSDAALRRISAVCAAFDVDGLRADLVTARTAVALAAWHARDHVTDDDIRSAAELALPHRRRRNPFDAPGLDQDQLDKALQEAADNDPDDDPDDDPGRGPDDPGGPDDGGPDDDDPDHGGQADGDATDSDATEADANQGGPDRRQPDAAPSAPHDGPPPSGPQAPADRAADDDTDDRPRRLAAAEQAAVRATNPYRTKLLTVPGIGRSQSDASGRRSQAEARRGRVVRSTRTDGPVTDVHLIATLLAAAPHQKARGRTAGLRLEKQDLRAAVRRGRESNTILFCVDASGSMAARQRMAAVKGAVLSLLLDAYQRRDTVGLVTFRRDTATLALPPTGSVEVAARRLEELPTGGRTPLAQGLVKSAEVLKIERRRNPHRRPLLVVVTDGRATYGPDARAAARRAAAYLAAEGTASVVVDCENGPIRLGLAQELAVHLGATAFRLEELNADNLAGVARGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ76</accession>
    <name>A0A010YZ76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569904.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1580"/>
    <dbReference type="HOGENOM" id="CLU_020027_2_3_11"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458017" evidence="1">
        <location>
            <begin position="32"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="43070" checksum="DEEE761EF534F9E0" modified="2014-06-11" version="1">MTNKANIFGKTALVLAAAAALTGVAASPAAATGGPRVDDALQREVAQHVLEAGPPGYLARIDNGRQVYTLARGVADKKTGRPIKATDQFEAGSNTKTFTSVLALQQVDRGRLSLDAPVEKYLPGVVPNGKNITVRRLLNHTSGLFSYTGDENFFANMAKDPQHVYTDAELLKIAFKHQPYFAPGKGWQYSNTNYTLLGMILQKQTGKSMATLVQERIAGPLGLEDTYYADPRATDTGEGFAHGYAIEFATGKPGYTDTSSWPIGSWGGAAGAIVTTADDLSTFLSGVLQGKLFSAAQLTQMKTTVPLPEAFPIKGGYGLGLFKTDSPCGTVWGHGGDTMGHHSTAVATEDGRRTAVTDSTGEPLEATENAGVKRYYEALVFGADAVTTCQMLGRPVPAEVLASLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZI0</accession>
    <name>A0A010YZI0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569928.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091709_0_1_11"/>
    <dbReference type="OrthoDB" id="2016227at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="19108" checksum="67FEBBC9E673B117" modified="2014-06-11" version="1">MSLETAHRPVCAEAATVPPPSTRAVVAAYVAAAAATVGFIPLHAIWALGIPLFADPDLFRPWYEDGGGTYLLTLNLLALLPAVLALALVRPWGLCFPRWVPIVRRRGVPRMLLIVPGAGLSAALLAYTLFAAALMPFQWNDPAAIFDPRTGVYGVIQFSVWITGLAIATRSYARRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0Q8</accession>
    <name>A0A010Z0Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2205690_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11642" checksum="9339323B74DDB934" modified="2014-06-11" version="1">MNRGVDNASEGRNGCHDEEVEKTADRAALLESPGTLADAGRVASALVDELDAIRRHWRSGTAAPAGTLQRRDAELGLYLDVLRTLCDPLLPPDQRDTDRATAFREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1V5</accession>
    <name>A0A010Z1V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570077.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2483"/>
    <dbReference type="HOGENOM" id="CLU_038686_1_0_11"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="34373" checksum="069A4C9DFEEDBBDC" modified="2014-06-11" version="1">MTETDAPAQGSGYGEKFHIRLENFEGPFDLLLQLISKHKLDVTEVALSQVTDDFIAHIRGMGDDWDLGQVSEFLLIAATLLDLKAARLLPAAEVEDEEDLALLEARDLLFARLLQYRAFKQVASFIAEREREGSTRWPRAVQLEERFSAAMPEVLLGLTPEQFAALAVKAMAPRPVPTVSIEHIHAPKVSVREHAAILRERLARLGQASFRVLCSDCTTTLEIIARFLALLELFREGVLQFDQVEPLGELHVRWLGGSRVEGSDRVAVEIDEYGSDADAPTAVPEQSGPADSSAPAVPASRTAPEIETKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z252</accession>
    <name>A0A010Z252_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850841.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2581"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="39468" checksum="955F2A463945727C" modified="2014-06-11" version="1">MRSVAARVARTSVGVGLGGFTGLLALGFLVVAGIVLAVTAGRGRPRIERAAIRLTALDRRRVHRFLGPGVAGEVCGARAVAYQGARAAIGSFGGLLWGLLLWGAATVVALIVGWVVGWPVDDIEATPFTVVYLAGLAAVLAFLNVEGILAVGRIDRWTADRLLGPGPGAAYERRIAELSTARSEVVAAVDAERRRIERDLHDGVQQRLVAVGMLLGRARRLPSADAKLAALLRQAHDEAADALVELREVSWRVFPAALDAGGLPAALETVADRSPVPVVLDVELDDRPAPPVETVAYFVVSEAVTNAVKHASASRVEVRVRGSADELAVTIRDDGLGGAAPGGAGLTGLDRRVTALDGRFRVDSPAGGPTTIEAVLPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z296</accession>
    <name>A0A010Z296_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="79" mass="8496" checksum="3DE414CE2266237D" modified="2014-06-11" version="1">MAQGTVKWFNAEKGYGFIAIDGGADVFVHYSAILMDGYKALEDGQRVEFLVTQGPKGPQAENVQLVSSTAERGTTWGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2N5</accession>
    <name>A0A010Z2N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080421_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="28176" checksum="DAE1362A90AC4C85" modified="2014-06-11" version="1">MRTDRLRVVFFLLVAGAALIAAFVVGPAALLNDKYGEYDDMATLPGRVAASLVEFCRGRTSTMPSSLAELVDYWFRWHAIKVAICVPMVMVSVLLVAALWSRYLRAGRRSAVWYLAGATGSMVCAALALGVLILNIQATSVPVVALLPLLPADAGGGPAELLRAAMNNGSGEQASPAALSVLLDEVARYYWILAFLSGVSALAGFAAGIVSWRRRATARRGRGMYAALTVVTVLAAGVMLMVFVVSTYSALTPSDALSGLLGFESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z331</accession>
    <name>A0A010Z331_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine/serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570204.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_3_2_11"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="24691" checksum="491333DB18A7394B" modified="2014-06-11" version="1">MTAATTRAVPLPGTYNVRDAGGYATAGGGSVRRGLLIRADGLSGLDDEGRAQLAALGVRTVIDLREGAEVEVAPDALGDLPIRYRHLPAFAGVAAQERPRSLQDAYHLMVDECGDALAAVIPALAEPGALPAVVHCTAGKDRTGVVIAIVHALLGVGAADVEADYAATARNLSTGFADKIRATMPPGEHTDAMLAEMLACPPELIRATLARIGDVEQYLTAHGLPPGAVAGLRAALLDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4I7</accession>
    <name>A0A010Z4I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851943.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3373"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="31338" checksum="34DB13DBF2107AF6" modified="2014-06-11" version="1">MNFGALVRQWRDRLDPADAGFTRTAKSRAPGLRREELAHLAGLSVEYVLRLEQGRATHPSTQVVAAVSRALQLRRPERDQLYRAAGLLPPQDSMVDDHVPPGVARLVARLGDVPIGIFAADWRLLSWNDLWIALHGDPALVPERERTIAHMLFGTGAAAAYLRPLRSESGPDAFAAAIVADLKEATVRYPADPGLAALVTGFRQTSPNFDQLWTTAGASMITSEEKTISHPEIGDVTLDCDVLTVRGVDLRIVTYTAAAGSADAGKLDLLRVTSGQSFRSAGREAESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6M8</accession>
    <name>A0A010Z6M8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853070.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4144"/>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="183"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="29965" checksum="33DC74DB5FD40821" modified="2014-06-11" version="1">MRVGIVGCGLMGSGIAEVCALAGLDVIVVETSADALERGRQRLATSLQRSAARRKVDDAAIVLGRIGFTTALADLADREIVIEAVAEDEAAKVAIFEQLDTIVASPDAILASNTSSIPIMRLGVATSRPEHVVGIHFFNPVPVLNLVELVPSLLTDPDVADAARDFIAGVLGKHVIVAQDRAGFIVNALLIPYTLSAVRMMESGFATADDIDQGMVRGAAHPMGPLALCDLIGLDTVHAVAESLYAEFKEPLYAPPPLLSRMVDAGLLGRKTGRGFYAYPPKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLG6</accession>
    <name>A0A010ZLG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_22_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="20242" checksum="B2BEFB838FFAE245" modified="2014-06-11" version="1">MIGFDLDMTLIDSRPGIGAVYEALSAETGVHVDTALVTSRLGPPLPVELANWFPADQVPAMVDRYRALYPALAVTPTIALPGALDALRAVHALGGSTVVVTSKFAPNAQLHVEHLGLPVDDIVGNVYAAGKGPALAERGAVVYVGDHTADIAAARAGGAVAVAVASGPFDADALRAGGADVVLESLTEFPDWLKASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM53</accession>
    <name>A0A010ZM53_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848512.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_1_1_11"/>
    <dbReference type="OrthoDB" id="2027769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="14072" checksum="80A201A7DFB3027A" modified="2014-06-11" version="1">MDEQRGQARRSSGSLERAVLEVLANSSGPLTVPEVRDALSVELAYTTVQTALVRLHTKGVLARERSGRSFAYRPVETPEAMQVGAAARRMRKILDSGGDRRGVLARFVADLSHEDEAILADLLAETEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMQ2</accession>
    <name>A0A010ZMQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">CryarDRAFT_1013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848724.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.995"/>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_11"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="427" mass="45043" checksum="9265F9071DB51056" modified="2014-06-11" version="1">MATIEAVAAREILDSRGNPTVEVEVILDDDTVARAAVPSGASTGAYEAVELRDGGTRYLGKGVEKAVQAVDDEIGPELLGYDAAEQRLIDQAMIDLDGTDNKGRLGANAILGVSLAVAKAAADSAQLPLFRYLGGPNAHTLPVPMLNILNGGAHADSNVDIQEFMIAPIGAGSFKEALRWGAETYHALKSVLKSQGLATGLGDEGGFAPSLSSNRAALDLIATAIDKAGYTLGTDIVLALDVAATEFYRDGAYEFEGAKKSSAELADYYTELVNNYPIVSIEDGLSEDDWDGWKALTSGLGQRVQLVGDDLYVTNPERLARGIAEKAGNALLVKVNQIGTLTETFDAVSLAHRAGFKCMLSHRSGETEDTTIADLAVATDAGQIKTGAPARSERIAKYNQLLRIEEELDDAATYAGTTAFPRYTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNT4</accession>
    <name>A0A010ZNT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CryarDRAFT_1410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849182.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1385"/>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="227"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="525"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EXG80339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="847" mass="93073" checksum="BDCFB69CFC3A4C54" modified="2014-06-11" version="1">MAGTNLTLGEARERGDLLEVASYHITLDLTDGTGKPGTDTFRSVTEVKFSARRPGASTFIDLIAKTVRAATLNGTALDVSGYDPEKGLELSGLEADNVLVVDADCLYMNTGEGLHRFVDPVDDEVYLYSQFETGDAKRVYACFDQPDLKATFTLEVTAPDHWEVVSNTTPEKAGAVRKFPPTARMSTYITALVAGPYHKVTDLHDDIPLGLYCRQSLKEFLDPDEIFEITKQGFDFFHEHFGVRYPFGKYDQLIVPEFNAGAMENAGCVTITESYIFRGKVTDYVRENRANTILHEMAHMWFGDLVTMRWWDDLWLNESFAEWAAHWAAAGGTRFTDSWAAFCTDRKGWGYRQDQLSSTHPIAADIPDMQAVEVNFDGITYAKGASVLKQLVAFVGEDEFVSGLRSYFKAHAFGNTTLADLLTALTEASGRDLSNWSAQWLETAGVNTLRPSFTLAPDGSYASFAVTQEGMAEHGTLRAHRIAIGLYDLSESTGKLIRRRRVETDIHGARTEIDDLVGETPPAVVLLNDDDLTYAKIRLDERSLSTVVDHIGGFTESLPRSLLWATAWDMCRDAELPTRDYVRLVLNGLAAESTISVVETQLRQARAALASYADPEWAPTGYALVADAALERLRAAEPGSDVQLVWARTFAGTARTDENIAVLKALLDGSEIVPGLEVDTELRWDFLQSLVARGAAGEAEITAELERDNTDQGSKEAATARALVPTAEAKAAAWHLATEDDTIPNQVGLSVIRGFGHPDQAALLEPYVERFFAAVSDVWARRTSEVAQNVAVLLYPAWAVSEDTVARTDAWLAGADHPPALRRLVVEGKDRLVRALRARACDASASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP09</accession>
    <name>A0A010ZP09_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569883.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1470"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="26255" checksum="86645FD84E95FE7E" modified="2014-06-11" version="1">MLATDTNTGVAAALHGVRKVYRSRSQHVTALDGVSLTFPTGSFTAVMGPSGSGKSTLLQCAAGLDSPTEGAIEVAGVQVHKLNEVQRTLLRRDRIGFVFQSFNLLPSLTAAQNVELPLRLAKRRPSGSEVRDALAAVGLADRARHRPTELSGGQQQRVAIARALITRPAVLFADEPTGALDSTTSREVLALLRGIVDRQRQTVVMVTHDPVAASYADQVVFLADGRLVGEIVGPTPDAVAARLAHLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPM3</accession>
    <name>A0A010ZPM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3631 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847651.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.187"/>
    <dbReference type="HOGENOM" id="CLU_041012_1_0_11"/>
    <dbReference type="OrthoDB" id="480234at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022081">
        <property type="entry name" value="DUF3631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12307">
        <property type="entry name" value="DUF3631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3631" evidence="2">
        <location>
            <begin position="174"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="432" mass="45993" checksum="3CF1420407769ECF" modified="2014-06-11" version="1">MTASGPRLTGAQLLDAIREALTRYVVLPSTEATDAVVLWIAATHAQPAWAHAPRLVIRAPEKRCGKSRLLDVVEATAHDPLITVNATPAAVYRSITSDPPTLLVDEADTIFGPKADGNEDLRGLLNAGHQRNRPAVRYDATAGRVEHIPTFAMAALAGIGAMPDTIEDRAVVVRMRRRGPGEAVAPYRHRRDRPAFRLLAAQLDEWLRSQMTELQEAEPPMPVEDRAADTWEPLVIVADMAGGDWPGRARQAVVALTAEADEKAGVSTRIRLLTDVRAAFTLLGDPPAAMTSDLLQALNSDPEAPWATFGPTGLTGKRLGDLLREFDISSDTIRFPVGQAKGYRRARFIDAWNRYCPLPEMPPADGAEDAGPGVPVPAVPPSFPQVIPGTGTTPVTDRSVTGDLPVPPLSSGNDLGTAGTGTPRAAGTGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPT0</accession>
    <name>A0A010ZPT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_0245</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847735.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.233"/>
    <dbReference type="HOGENOM" id="CLU_009218_0_0_11"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458245" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="117"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="12">
        <location>
            <begin position="514"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="13">
        <location>
            <begin position="765"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG79217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1010" mass="105518" checksum="B4AD78FC670528B4" modified="2014-06-11" version="1">MRLLVANRAEIAVRICATAAALGVETVAVHPDDDANCAHAARADRAVRLPKAGAAAYLDVDAIVEAAVRTGCDALHPGYGFLSESPALARACAAAGITFVGPSPESLELFGNKVAARERAEALGVPVLASTSDLASAHDFLARHGAVMVKALAGGGGRGMRPVTRPEDLDEALRRCASEARASFGDDEVYVEQLMVGARHIEVQVVGDGETTVVLGDRDCSAQRRRQKLVEIAPAPALPDPLREALHAAAERLVSDYRGLATVEFLVAGSEFAFLEVNPRIQVEHTVTEEVTGLDLVELSLRVAQGGPVPGPVPSRGFAVQARVNTEGGGTLTRFQPPTGRGVRVDTHGYVGWEIGPRYDSLLAKVIGTGSTLEAAVARVSRALAEFDVDGVPVNTAQLANVLAHTDGTLTTTFVDEHVPDPAPVAVAGAVVSPLLGVVVAVSVGEGDLVAADAELVVLEAMKMEHVVRGGRPGRVENVAVKVGDTVALGAPLVFLSESAEAAAAPSATAAADPDRIRPDLAEVLERQQLGSDEVRVAATERRHSRGRRTARENLADLLDPGSFVEYGALTIAAQRRRRDLADLIARTPADGLITGTGTVDGRPTAVMTYDYTVLAGTQGIHNHRKTDRLFQLVARERLPLVIFAEGGGGRPGDTDTSAVAQLDVETFRLLAALRGVVPTLAVVAGYCFAGNAALAGSCDTIIATEGSSLGMGGPAMIEGGGLGVVAPGDVGPMDVHWANGVVDCLVPDEAAAVAHARRYLSYFSALTDFAAGDQRILRNSIPENRLRAYRIRPVLEALFDTGSVLELRGGFGVGVVTALARIEGRAVGVLANNPEHLGGAIDGDASDKAAAFLELCEAHRLPVVSLCDTPGFMVGPDAERTATVRRFSAMFVAGARLTVPLVTVVLRKCYGLGAMAMAGGSLHAPALTVSWPTGEFGGMGLEGAVRLGFRAELDAIADPGERRARFDALVADYYERGKALNVATVFEVDDVIDPADTRRVVSSALSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPY6</accession>
    <name>A0A010ZPY6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="12" type="ORF">CryarDRAFT_1822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849775.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1791"/>
    <dbReference type="HOGENOM" id="CLU_007894_3_0_11"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="821" mass="84371" checksum="97CC570B1BABF03F" modified="2014-06-11" version="1">MTRATLARAVFACAIVAVSIYLTVTSSPRLGLDLRGGTQIVLETSDTSTTKADAEATDRTVEVLRRRIDALGVTEPTITRSGENRIIVELPGVQDPAEAAAVIGRTAQLTVRPVLGFDESAVPTPGATPGTPSPGSTSPGSTTAPSSPAAPSGSPTPSPATPGTGAPSAPAATPDVKAPPADPGKEITLPDDSGVPLKLGAAALTGEGIASAAANFDATSGLGWFVTVDFRGAGEQAWETVTGKAACSPSGDPTRRVAIVLDQEIVSAPQVGEDVRCNVGITGGSTQITGQFSKAEANDLALLVKAGALPVPVETVEQRTVGPTLGATAIRASAEAAVLGVALTIGFLLLVYRLSGLVAAIALAGYGALSYGALTALGATLTLPGLAGFVLAIGMAIDGCVLIFERSREDFAGGVSKRGLPAAVSSGFKNAFSAIADSNITTLLAAGLLFFLASGPVRGFGVTLSLGVLASMVSALLFTRVLMELLVSSKWVRQHPSWTGLSGPGRVQRWITSRNFNLMRHRKVFLSVSAVLVVLAFAGIGIRGLNLGVEFTGGRLMEYTTTQSIAIGDARQAVAEAGFPRAVVVESGDSDVSVRTEKITDDEEQSIRTALADASGGSVERIRDEQIGPSLGDELRTKALIGLAVALLAQAAYLVLRFRWTFAISSVLALLHDVVIVVGLFAWLGKSLDGVFLAALLTVIGYSVNDSVVIFDRVRERWRGANRKTPFADVANEAVLQTVPRTVNTGLGALFILGSLAFLGGDSLTDFAIALLAGVVVGTLSSAVTATPLAVVLEKRWPGRIRGNNSSAKKQPVKAGSGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ38</accession>
    <name>A0A010ZQ38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnulose-1-phosphate aldolase/alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849824.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1816"/>
    <dbReference type="HOGENOM" id="CLU_024866_0_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="677" mass="70405" checksum="A92326D8FA29642B" modified="2014-06-11" version="1">MNETVAALLARSNRLGADPRNTNYAGGNTSAKGTDVDPVTGGPVELLWVKGSGGDLGTLTESGLAALRLDRLRSLVDVYPGVDREDEMVAAFDYCLHGRGGAAPSIDTAMHGLVDAAHVDHLHPDSGIAIATAADGEKLTAEIFGGKVAWVPWRRPGFQLGLDIAAIKAGNPGVIGTVLGGHGITAWGATSEEAEANSRWIIETAAAYIAAQGAAEPFGPVVAGFEPLDPEERHAKAAALAPVVRGLASTDKPQVGHYTDTDVVLEFLSREKLAPLAALGTSCPDHFLRTKVRPLVVDLPASATVEEITARLTELHAEYRAAYQAYYDRYRVEDSPAIRGADPAIVLVPGVGMFSFGANKQTARVAGEFYVNAINVMRGAEAISTYAPIDESEKFRIEYWLLEEAKLRRAPKPKALVGRVALVTGAASGIGKAIAARFAAEGACVVIADLDATKAAAAAEELGTTDVAIGVAANVTDAAGVQAAFDAAALAFGGVDLVVNNAGLSISKPLAETTEADWDLLHDVLAKGSFLVAQQAARVMTAQGMGGDIIYISSKNSVFAGPNNVAYSAAKADQAHQVRLLAAELGAHGIRVNGINPDGVVRGSGIFAGGWGAKRAAVYGVPEEELGQYYAQRTLLKREVLPEHVANAAFALVGGELTHTTGLHVPVDAGVAAAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQA2</accession>
    <name>A0A010ZQA2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">CryarDRAFT_1939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569968.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1903"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_11"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="294"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="378" mass="39926" checksum="2AE86DABBDA7F64E" modified="2014-06-11" version="1">MTSSDPSSHLAAPESPLRRSPLHDRHVALGAKFAEFGGWEMPLQYSGVIDEHTAVRTGVGVFDVSHLGKALVAGPGAADFVNATLSNDLGRIGPGKAQYTLCCDESGGVVDDLIAYYFAEDRVFLVPNASNTAEVVRRLAAAAPSTVQVTDKHTDYAVLAVQGPRSAELLAAIGLPADHDYMGFVEAEHEGVPVIVCRTGYTGEHGYELLPKSEFAEPLWDALLGAGEALGVRPAGLGARDTLRTEMGYPLHGQDLSLEISPLQARSGWAVGWKKPAFWGRDALLAEKEAGPARRLAGLEALDRGIPRVGMAVLDADGGRIGTVTSGTFSPTRKVGIGLALLDTAAGVAVGDEVTIDVRGRRSRVRVVDPPFVPSHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQF1</accession>
    <name>A0A010ZQF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850028.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1964"/>
    <dbReference type="HOGENOM" id="CLU_075524_0_0_11"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="28516" checksum="E72762A97A2F379F" modified="2014-06-11" version="1">MKHLVGRHDLLFVTFDTLRHDVAAELAAAGRTPNLARVLPGGQWERRHTPASFTYAAHQAFFAGFLPTPVTPGPHPRRFAAAFPGSESTTDDTWVFDAPDVVTALRETGYHTVCVGGVGFFNPVSALGRVLPGLFAESHWEPAFGVTNPACFEAQLDRIESVIAGLDPARPLFLFVNVAALHQPNRHYRPGAEHDSRESHAAALEYVDAHLPRLIAAVTGRGRPCAAILTSDHGTAYGEDGHVGHRVAHDVVWTVPYAEVVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQS9</accession>
    <name>A0A010ZQS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570002.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432375_0_0_11"/>
    <dbReference type="OrthoDB" id="1941009at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="20319" checksum="53D23527E3DB11AA" modified="2014-06-11" version="1">MSRPQSTYPHQQAGRQPADSYPDRSYPGYGSDDQDPPNRYPGNDRGTSKSSKSSKRKAIIATVAVAVVGGSLLGLGGAEWWSSRDSGPKTAPAHSLEQIADKVGCEPTSVRKSSDFSQGVCMLGETRTTILTFESNQKMTDWIEAAEGYGGAYLVGTKWLVTSNKAETLDPLVDKLGGGQIMLDSHYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQT5</accession>
    <name>A0A010ZQT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative polyglutamate capsule biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570004.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2100"/>
    <dbReference type="HOGENOM" id="CLU_038823_1_1_11"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="55"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="40670" checksum="26B5FAB6A8C7D0AF" modified="2014-06-11" version="1">MTSGYRGRWFLLGLPVAVLGVLAVTTTGPGGGSPDASFLRMVPPAASAAPAPTVRFAAVGDVILGSTPKLPPNGGRTFFDDVRRELTGDVVSGNLESPLTDRTVSTKCARRSAGSAGPAGSAGPAGAAGPAGAGVGRAAKARSCYAFRVPPGYARWIGGAGFTVMNVANNHARDYGDAGLTDTVAALRRYGVDHTGPAGVITRRSVHGIRVATVGFSPYAWTNSVLDVPAAAALVRRAAASADLVVVQMHIGAEGADRAHVRRGPESFLGERRGDPIRFAHAVVDAGADLVVGHSPHVLRGLEFYRGRLIAYSLGNFAGYRTLSTAGPLGVGCVLRVALRADGTWAGGTLVGTHLVNGGLPARDPRHRALTLVRTLSTADFGRAAARVSPTGGLAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR05</accession>
    <name>A0A010ZR05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2172"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="22904" checksum="25F6DB0502B2CA7E" modified="2014-06-11" version="1">MSDVTTVLLVDDEELVRMGLRAVLDAQPDLRVVGEAADGAEVPPLVARLRPDVVLMDVRMPAVDGIQATRQLMASGDSPPRVLVITTFENDDYVYAALRAGASGFVLKRARPAQLVDAVRVVARGDSLLFPAAIRRLAGAYGVGAALLADARLTARELDVLRRMAAGRSNAEIAGDLVLSVETVKTHVGNVLGKLGARDRTQAVIVAYESGLITPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRF7</accession>
    <name>A0A010ZRF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848535.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075566_1_1_11"/>
    <dbReference type="OrthoDB" id="1886330at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="19558" checksum="0CA384854A842AD2" modified="2014-06-11" version="1">MTSQGFARESRAGVFTLVCLSLSVVLHTVAAGSTPSAPAILAGAGLVLVVAFALAGRERRFPLIATVLIGAQFGLHYLFEALPHAGHHGEAAIASVPLPPGMVLAHLVGGLLAALWLRGGEAAAWRLLRWMARGVSPLRGLWFVLWTLVVPASRPALPVSTTRAIARPAPGWRHSVIRRGPPALSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRI1</accession>
    <name>A0A010ZRI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848580.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.832"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="5">
        <location>
            <begin position="97"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="958" mass="102670" checksum="EF17EEB025B7CEDF" modified="2014-06-11" version="1">MPQFRLLGPLEMTVGDRVVNLGPVKRRTVLAALLVDVGRPVRVETLVDRVWDDEPPAKARDVLYAHIARIRSALVGSNVVVERRSGGYALHVDPDQVDAHLFRRLVAEARAEDCPDERRATLLRAALDLWQAAPLADVPGSWAAGVRENLEQQRRSAVALWARTLSDLGRPAAVVDTLRELVTAEPLAEPLLVELVRALHRAGRAAEALDTYARARARIVDALGVEPGPELRAMYEAALHADERTEQPASTPTVTAGESGPVPAQLPADVPAFTGREPALTELTERLTGPRPAGAVVVSAVDGTAGVGKTALAVRWSHQVRDRFPDGQLYVDLRGYGTEPPVPPAAALAGFLTALGVAARDVPLDIDERAARYRTELSGRRLLLVLDNASSVEQVRPLLPGSPTCATLVTSRDVLSGLVAVDGAHRMFLDLLEPAEAIALLRSLVGRRVDDDPDAAGELGEQCGRLPLALRIAAELANARPQSPLADLVTELADHRARLELLDVGGDPRADVRAVFSWSYRRLPDRVARMFRLLGAHPGAEFDAYAAAALADVDVSDAVGALDALARAHLVRPVAAGAYDLHDLLRAYARSESDPGDDTEAGTRLFDYYLAASAAAMDVLYPAERHRRPVPPAIRTPLPVLPSAEDARVWLDRHRAVLIEVAQHTAAHGRSDVTGALASTLYVYLDNGGYSADALTVHSCALDAASRAGDRAGVAAALSHLGVVYWQMGRYPDGTDHLERALVVFRELGDAVGEARTVGNLGVICQQTSRYVEAEEHHTAALALFRKIGDRVGQANTETNLGDILMRFGRNEEAIDLLADALEQFRGLGHDGGEATALTNLGEVHLSLGRPEEAAGYLRQAVRLFASIGERYGETCALNGLAEAELGRGSASAADRFAEALALATTIGERAEQARAHLGLAQATDRAREHLEQALALYTDLGSPAADDVRKRLENLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRJ1</accession>
    <name>A0A010ZRJ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725862.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.852"/>
    <dbReference type="HOGENOM" id="CLU_072997_0_0_11"/>
    <dbReference type="OrthoDB" id="1626415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="27542" checksum="B2B8AF64D2E76917" modified="2014-06-11" version="1">MRFARRWSWVAVLVIGLALFYAVRRATLDTGNPNLIPSLILLGAAVVPMTFVAFLAGRRIEYGVSGGTLALTALVGGVIGVVTAGVLEYDTLHDLGVLPMVAVGLIEESAKLIAPLVLVFVLKPRKPADGLLIGVASGAGFATLETMGYAFVTLIQSKGDIGAVDDVLFLRGVLSPAAHMAWTGLTAAALWYAAESHWHASAVMRFVGVFAVAVALHTAWDSLGNTIAYAILAAVSLGLLGVTTHRLTARHRVPSGHGPSLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRT8</accession>
    <name>A0A010ZRT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052583_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="27260" checksum="9D37FB05F4EA2DA7" modified="2014-06-11" version="1">MPTKLTARPPALLRGWLFFLVAALAVLTGSAAHVVTRPVTWSAQAVIAFVPVGERPVSASSVTLMVPRYVAYAASPYVVRQAAVAVGIRPAELQGGLTVTMPATTANVAIAVAGRSPGIASEAANRIAALVVERASADPVLAARVLAEAPLPTAADGPSEAVLLGGAAVGALVVGTLAALGVRWYVRRRYPRATVPVVPATLRRPGPGTVLATAPLARPEPLEDTVPMSALDEPTVDDRHLADEDTVSFDPATVIVRSITPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS44</accession>
    <name>A0A010ZS44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850822.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2567"/>
    <dbReference type="HOGENOM" id="CLU_046737_12_4_11"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="17786" checksum="7E4CBD84493F07EE" modified="2014-06-11" version="1">MSITLWTRRDPFAEFDALVRRSFGPVATRPAETRRNFTPAAEVTRDGDDAVVRLEVPGVDVENDVTVEVDAGQLVVRGERRGEHDGRSFSEVRYGSFRRTFRLPEHVGADAVTASYDQGVLSVRVAGAHTAPAQPETRRIAITTAPAAESPTESPAASTVDHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSR8</accession>
    <name>A0A010ZSR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265194_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458073" description="DUF732 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="3">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="22395" checksum="07BF34C1B9BD2024" modified="2014-06-11" version="1">MGYRVSFGLRLLGVAAIVGLVVWAANAAEVAAPKGLKTAFSALTSGPAAAKAATPSTTPTAAPTAAATTSTGATTSTGATTSTATTATTGATAAATVTATTAPFMATMTNKCVPDASLPKTYYAGKNCADPDLRYNKYLVTLSTEVYKVFGYQPKMVQLGEETCGELKIYDQTRVVMDVTQWLVAEQAPANPRKAALSVLNAATKNLCPDLRSKVTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU52</accession>
    <name>A0A010ZU52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374180_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="742" mass="73543" checksum="C7B9E0127CA1CFB3" modified="2014-06-11" version="1">MAPGDQLSDVAERFLGDPDRYPELATGSGLADPDEIRPGQRVQLPPGVHDRGSDAHATGRVEAAAPADPAPGAPAPGAPAPGVPAPGNPAPTPGKPVPAPSTPAPRGPGPASPAPSAPAPGNSAPGNSAPGNSAPGNSAPGGSAPTAPAPRTRAPGQGAPGTAAPTAPSAPAPSAGAPSRPAPGPGAPGTAAPSAPAPRTPAPGTPAPSRPAPGPGAPGTAAPSAPAPRTPAPGTPAPSAPTPGPGASSTTTPNPQRPGLPGPGEGAPGTAAPSNPAPSNPAPSNPAPSNPAPSNPAPSKPSAPAPRTPAASTPAPGKSAPAQPAPTNPALTNPAPTKPRPDASSLTPAPGGVPQDDDATRTQPTSHSEELSPLLPIGVPLAGAGLLAALLLARTRRQEAVVGRHRRHRGTRATTTPKGTPKTIPTIARDGFVAAPPRPRTSLAPPPAAEPDANQRLDAALRALSTALADRDADAMPDVVGAWVGRGVVRLVLDRPCPNPPAPWTGGELSWELPADAELPDPAGIPAPLPMLVTVGSRGSSSLLLDVERLGVVTLTGDTWRADDLLRHVGAELAGNPWSDDLEILVAGLDREQADNLAMIGDGRIEPVASIADGISRMRRRVSQALGVEPDVPGRHAAKDDAEDDEWVPTVLLAADPDLEETIALGELDAELATTGRCGVGVVASIRGDLGRWPLDITGEGAMSAAFLGFREPELLAARLSPSRLGSLAELFVDSALVPKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUB6</accession>
    <name>A0A010ZUB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570395.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="16075" checksum="6BA48CA501AF419F" modified="2014-06-11" version="1">MTSRTAEASPSLSQSINRVARALARHGDAALKPLGLRYAQIPVFALLKMRTGLTQKALADATGIEQPSMAQLLARMDRDGLIESRPHPTDARSRTIVLADPDDRRIDEGSKRLMDLERQAVEGLGKEEVETLKALLARVLENLEGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUZ1</accession>
    <name>A0A010ZUZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643585_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="426" mass="44717" checksum="C909BE3F7ED3479A" modified="2014-06-11" version="1">MEPALLAASAEDAAAAAAVHVVAAAVGFASTIALWISILMGTALGRSWSLPWIKHASLKNMHMSFAIGGLALGIVHGLAQLAAPGTYVRVIDEFIPFINPTKPIGVGLGTLCMEMFIAIALSVPVQRRLGHARWRMLHSTAYAAYTVTAAHLVFTGSEVKGLVTWAVIASWVIATGFWLAVGPNKYGKRLETVAVGLHEKRVNTTTVNVDPHVCARFGFCEHEAPEVFKLQHTGRLAYRTTVEPHEVDKVYNAVKICPARAITMTGPGVPFDLTIPPGAESTGQKLNIGPTTGPGQDYAPGVPSDNRETTVVPHIAPVSPVDGPRAVPDVPTPGPRAVPDMPTSPAAPSQPSGPMPVPAGASSGPGAPRPTGRLGPFPPGGPGRRHGQPVNPPPPPPLRSVPNRPERRDNTGQFNNVTGLRPRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUZ2</accession>
    <name>A0A010ZUZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycopeptide antibiotics resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570565.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077618_8_1_11"/>
    <dbReference type="OrthoDB" id="1262421at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="21451" checksum="05F7FF8A605F5D18" modified="2014-06-11" version="1">MPAPYDEISRLSVALPLAAAAIAALLWRLRRRAALTWPRVLVVVTFCVYATAVLAATLLPVPLGEPDYHVAWQWFVNLTPLVHAEWHDVLQNVVLFVPLGVLLPLVARVGSVGRVLLAGVLASLTIELLQFVADVVFHAGHAVDVNDLLANVLGAPLGYGLLRVALRLRALARLADAATWPVRTPREAGSHQVGEPSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV01</accession>
    <name>A0A010ZV01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852394.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3680"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27411" checksum="B8E0E1CCDC6FD2B0" modified="2014-06-11" version="1">MSLVVTDLRVEFSGFVAVGGVSFDAHPGEVRFLIGPNGAGKTTCIDAITGLTKGTGSARLGETELLGRPVHTIVRLGVGRTFQTASVFDELSVLQNLDIAAGRHRRPASLLRTRTGVDASIERALEETGLAGELATPAGILSHGQKQWLEIAMLLVQDAKVLLLDEPVAGMSQDERTATGELLQRVAANRIVVVVEHDMDFMRRFATRVTVLHQGAVLAEGAVSEVQADPKVQEVYLGTAGAATTAAASAVPEPLRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV83</accession>
    <name>A0A010ZV83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850307.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2190"/>
    <dbReference type="HOGENOM" id="CLU_097806_4_1_11"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="12510" checksum="1B10482FA55D8D01" modified="2014-06-11" version="1">MPESTRELAHPEPADFVLTDVLFALSDPSRLAIVRQLADGPVETVGCQTLGGEIPKSTRSHYLKTLREAGIIRNVAHGRERLVSLRVDELEARFPGLLASVLAATGGDSSPADPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVA6</accession>
    <name>A0A010ZVA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850348.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2217"/>
    <dbReference type="HOGENOM" id="CLU_030671_0_0_11"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="30228" checksum="3C04C48C69AD4661" modified="2014-06-11" version="1">MNGTTAPDFPSNWGRWGDDDELGAVNLITDEARARGAAEARTGVTVSLARVTTPFPLTGGPMGATTASTTAVQTAMLFTGFGAPAMAEVMIVTTHHAEVTHLDGMSHWVAGGKVYPGVDVADSSGPTGVRHGAADVYADGIQTRGVLLDLAPGGRLDPGHPVTGADLDAAAAHGGFEVLPGDAIVVRGGWDRVNGSAEPEPGMTADAIRWMHDHGVAVYAGDIGDARPPLPDDVPGALHFLALGRLAIPLVDCAEPEALAAMCQRLGRWTFQLVIAVPRIAGTTGLPVNPIAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVD1</accession>
    <name>A0A010ZVD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2240"/>
    <dbReference type="HOGENOM" id="CLU_093484_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="17568" checksum="E8684B9113C1DB89" modified="2014-06-11" version="1">MTTLAPSAAPALRRLYLVRFGFAVVWAILLTSTGADLNPVSVGLLVLYPVFDVAAAVVDLRSSRTSTLAVNAAVSALAAVGLAVAAAAGVPAVLRVWGAWAIVSGLVQLVVGVRRRALGGQVPMMLAGGISVLAGASFAAMAGADDPAVAGVAGYAAVGGVFFLVSALRLGRAARGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVW5</accession>
    <name>A0A010ZVW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Indolepyruvate ferredoxin oxidreductase, alpha/beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_4005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3979"/>
    <dbReference type="HOGENOM" id="CLU_009166_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="436"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="POR" evidence="8">
        <location>
            <begin position="707"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1124" mass="119288" checksum="7EBD4381D11740B6" modified="2014-06-11" version="1">MTVTLDDKYTADDGRVLISGVQALVRLMLEQRRLDDVRGLDTRVFVSGYQGSPLGTLDLEMGRAHRFLDPAGVVFRPGLNEELAATAVAGTQMLGRVPGARHDGVVGFWYGKNPGLDRAADAIRHSNVAGTTTLGGAVALIGDDPGSKSSTVPSSCEPMCENLSMPLLAPGTVAEIVEYGLHAVALSRASGLWVGLKVVADVADASATVDVTGLSAGVPVPPGTPRAASPALVGPASLDAEHDMLTRRLNLAREYARAAGLNRVVFSAREAKLGVLASGTSFAAVQRALDDLGLDEAAQEALGLRLIKLAMPFPVDHEMLAELTAGLDEVLVVEDKYPFLEGHLKQALYRRADAPVVVGRFDEAGRPLLTARGTLGADEVARALALRTGLPPRETATAGRPRLALPTISARTPFFCSGCPHNTSTRTGDDTLVGVGIGCHAMVALAPDGRGNQVGLTQMGGEGAQWIGLAPFTDDRHFVQNLGDGTFHHSGSLAIRAAVAAGVTMTYKLLYNDAVAMTGGQRAEGRLDIPTLTRWLATEGVRSVVVTTDDPGSYRTVRLDPIASVRHRDDFADVERALSAVDGVTVLIHDDRCAAEERRLRKRGQLPTPAERVVINERVCEGCGDCGDQSTCLSVQPVDTEFGRKTHIHQASCNSDFSCLKGDCPSFLLVEPGTPERRAVPDLPVALSEPERRFGGDDVLLRMPGIGGTGVVTASQILQMAAHLDGRHAAGLEQTGLAQKGGPVVSDVRLSKTPLTGALRASRGTVDVLIGFDLLGAAAQPNLDTARAGHTIAVLNTAIVPTADMVTGRVVLPDSPADALERIASVTRSEANVHVDALGLAEALFADHMPANMLLLGAAYQHGCLPISAEAIEDAIRLNGSAVEATLAAFRWGRAAVVDRAAVLAALTTTRPAPKATSLEEVLALRVADLTGYQDAGYAERYSDDVRRITAAATERAGAAAGERIGLAYARGLHRFMAYKDEYEVARLHLDTVEQARRDAEFGADADVSVLLHPPVLRALGVNRKIRLRRTARPAFLALRAGRRLRGTPLDVFGYAHVRRVERELVAEYRSAVHRAVRHLDAGNADQVVEVADLADVVRGYEDIKLARVAEFRDKLRTALAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVW8</accession>
    <name>A0A010ZVW8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">CryarDRAFT_2463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850650.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2426"/>
    <dbReference type="HOGENOM" id="CLU_089358_1_2_11"/>
    <dbReference type="OrthoDB" id="1680292at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="17144" checksum="710160C5047069CF" modified="2014-06-11" version="1">MSGGGLADLGPIDAGGVRLGVVATRWHAEITDRLLDRALATAALSGVTDVLTARVAGAVELPVVAQELAQRCDAVVALGVVVRGGTPHFEYVCDAVTAGLTRVALDSATPVGNGVLTCDTEAQARDRAGFEDSAEDKGREATIAALDAALTLRDLRRAPVPQVGFGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW31</accession>
    <name>A0A010ZW31_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="16" type="ORF">CryarDRAFT_4076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852897.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4050"/>
    <dbReference type="HOGENOM" id="CLU_066192_45_0_11"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="93"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EXG82874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22947" checksum="AB4A1E912B45440D" modified="2014-06-11" version="1">MNEDLDTSVLSERQRRILAVIQRSAQRFGYSPSTREIADAVGLASASTVSRHLRRLEELGFLRRGRATRPIDVRMFLEPVAAPREDPGTIGVPVLGDIAAGTPILAEETSDEVLALPRDLVGKGTLFGLRVRGDSMIDAAICDGDIVVVKQQPEAYNGEIVAAMIDDEATVKVFRRRGGHVILEPRNPAYADIDGDHAVILGKVVSVLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWA8</accession>
    <name>A0A010ZWA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853049.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4134"/>
    <dbReference type="HOGENOM" id="CLU_107911_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="22641" checksum="C7CDAC7FCE780ED8" modified="2014-06-11" version="1">MPYDNRTRAAAARETRAAVLAAARESFLTSGYAATTIRGVAEVAGVSQETVYKRFGGKAGLLKSVYDIAMAGDDEDVPIAGRPQSLAVHRATTPRETTRAYAALARWLMERAGAVLRIVVPARGSTPELDAFMHTIDGERLIGTRMAVTAWDEHGWLRPGLGRDRAVDIVWTLNSPAVWLLLDERGWTGEDYERWLRETLDATVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWG0</accession>
    <name>A0A010ZWG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570106.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793269_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="14699" checksum="6B5DA5AAAFCFCE42" modified="2014-06-11" version="1">MRLVRAVPALLGTAILLYGMLGLLGASGPSPLGRWLLVVVVGWLAVDAVLTPVVIAAGRLLRRLLPDRPGDRPGRRGAVRVLVGAAAAVSGVLTLVALPLVDGGGRDASVPSALPLDYGRGLVLLLAAGWLGVGVAVAVLLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX87</accession>
    <name>A0A010ZX87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079045_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="27827" checksum="CE3DB949ADA9035B" modified="2014-06-11" version="1">MTTQDVPVLEVSEPQAGEAPGFAVGVTLGGKLAPDVARYARTAIRAAVGDHRGPVLRADVRIVRYDDPSLERPVASYATVNLNGTRVRVHTTATTAHEGLDELRQELRAALDRSDSDRRADAQRRPAATQMPAAPRIRVPGVVSGECSVDEAIGVLDLLDRDFELFHDSGSGEDTVVYRAGPTGYRLVQARRSPIERCPAVAVSIDREPAPRLSVEVAAIRLARSEAPFVFFTDVATDRGTVLYVRRDGDYGLVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXL3</accession>
    <name>A0A010ZXL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3024498_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="55" mass="5838" checksum="29034DC24797BC44" modified="2014-06-11" version="1">MSSSTLVSTPRTLPSSGSRRPARPVARLSTPPADRGRTAAECPPDCDYCYGPETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZQ9</accession>
    <name>A0A010ZZQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852643.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3881"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29874" checksum="12E2291DEC52325E" modified="2014-06-11" version="1">MIVKRGETVTGRVLLVLLMAVTIIPFVSLFVTALHPSGTYPSGLAWPESPQWGNFVDAFQVANMGALLVSSGLIVLGVVPISLVFGTMAGFAFGHLRMPGHRIGFLAFVLGLTLPFEGIITPLYYQVRDLGLLNTRWAIILPLIGLFMPFSVVWMRAHFTTMPEELSEAARIDGASTWQLFWRVHVPLAMPALSSLAILLFLWTWNQFLLAIVLVDDPAKRTMAGALGAFQGQWGTNIPLLCAGALLILVPTLAVFLVFQRRFVAALLQGSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A051</accession>
    <name>A0A011A051_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852853.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4026"/>
    <dbReference type="HOGENOM" id="CLU_038930_0_1_11"/>
    <dbReference type="OrthoDB" id="1421520at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="DUF917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="DUF917_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="DUF917_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="DUF917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="362" mass="37206" checksum="B42878AF6098BC0F" modified="2014-06-11" version="1">MALITDRVTAVAVTDVAALAAGAAIFGTGGGGAVYTTQIVAEAALADNGPVELVTVGDLGPDDLVISMSGIGAPTVGIEMLSSAGQIELLVREAERAAGRPITTLMAAEIGGSNGVGPVGWASRLGLKLLDADGMGRAFPDAAMVAMNVAGVPCDFSVLSDVVGNVSVIKTVDLHWLERHARALTVASGSICLGVHYPLTHETARGAVIEGTVSAAIRVGHALLSSPEPVAAVAAALDGKILLTGKIADLDRRTEGGFARGSVTIAGTGADRDRLQRIELQNENLIVLEDGEVLVSVPDNVTIIDAETGHAITTEMLRYGQRVSVLAWACDPIWRSRRGLELAGPQAFGYDLTYVPFGGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAL9</accession>
    <name>A0A011AAL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.80"/>
    <dbReference type="HOGENOM" id="CLU_039914_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="34360" checksum="2F0946C77C3B8985" modified="2014-06-11" version="1">MSSSTPTRTRADATDSHSGTIGLLIAAIVAVLIGRQVLALLIGGRGGVATWTTVFCAIVVQALPFLMLGVVLSGAITAFVPARFFSTILPKRAAFAVPVAGAAGALLPGCECASVPVAGRLMERGVVPAAALAFLLSAPAINPIVLVSTAVAFPGQPGMVVGRFVASLATAVLVGWIWARFGRPEWLTRFAARRLPSADDTTPAFERFRLAVAHDFFEAGGFLVIGAAAAATMNVVIPPDWISTVAGIPVLSILVLAALAVVLSICSEADAFVAASLTGFPVSAQLAFMVVGPVVDLKLIALQTGTFGRAFATRFAPLTFVVAVGAAVVTGLLIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB48</accession>
    <name>A0A011AB48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma 54 modulation protein / S30EA ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847754.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142879_0_0_11"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="13110" checksum="0BF24BCC26D600CD" modified="2014-06-11" version="1">MQILLNTDKHVHVDNAMREQIEAEVASVLARFSERLTRVEIHVSDENAAKSGGTDKRCLLEARPAGQPSVTVTHDAASVDEACTGALHKLATLLESKYGRWDNRKGGQSIRHLPVAEGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABE6</accession>
    <name>A0A011ABE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formate-dependent nitrite reductase, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569599.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045348_0_0_11"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="297" mass="29646" checksum="FCC57F218EDA75F8" modified="2014-06-11" version="1">MAGEPSTVPSHYVHRSIRVTPARQAPDIPAYLYFGGIAGASAGLAALAELTGERRLAAASRYATAGCALAAVAATARDLRRPQRFLAGLRAPDPSFPLSLGTWLVLPFAGLAIVTAGAERAGWRLAAGVTGAAAGVLGPAVCTYTAVALVDTEVPAWHEAYRELPFLFAGSGISGAAGIALIATLSGDPAPARRLAVAGAAMELAATARLRAAPGSAGVSFRGGTAGRLLTAAATLTTVGAALAVLGGFATGRRPAIGRWATAGAGLALLTSGALSRLSVHYAGQHSAEASRFGNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABM2</accession>
    <name>A0A011ABM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072005_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="25518" checksum="B6A73556929A3EA3" modified="2014-06-11" version="1">MTLPGAASMALAPVLSGPTRSVTVTAALPRALYLATGDPHVPALCVIAADAVRVPCAIRLGPGVPVPTAVVGSTAYVGDGRLAVGDRAVAVTRWWRPSRPRVQLSDLHARQRALRTDADVSALSGTSVRELLGRGEGLTPYGDDILSGALVTLIAGGHHAGQVIASMVAHELATRPGATTAVSAALLTHAMRGECIPELAAVLTDPLERLDSAVEALLRVGHSSGGGLLQGVRTGLEVLTGPAPTVRMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABP8</accession>
    <name>A0A011ABP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848106.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.471"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_11"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="389" mass="41357" checksum="80D693F0427FF007" modified="2014-06-11" version="1">MGTNGPLDGVLVVDLSRALAGPHAAMMLGDLGARVIKIENPSGGDDTRSWGPPFVGPDDSISTYFLSCNRNKESVTLDLKSDFGADTLRRLVERADVLVENFRPGVLDRLGFSMEQLHELNPRLVVLSITGFGHDGPEGGRAGYDQIAQGEAGLMSLTGPSADEPTRVGVPIGDLLAGMYGAYGVVAALHERNETGRGRVVRTSLLAAIVGVHAFQGTRHTVAGEVPTASGNHHPSIAPYGLFHCADGSLQISVGSEALWRRFVAAFPSLDRPEFGSNPERVRARDAVIAAVDEVFSALPLAELLPKLAEIGVPAGEVRTLDRVYDWEQTRSQGLLVDVDHSVLGSITLPGPPLRFDSNQFAGGRVENIAPPTLGQHTDAVLAWLDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABS1</accession>
    <name>A0A011ABS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.502"/>
    <dbReference type="HOGENOM" id="CLU_020884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="127"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="376" mass="40581" checksum="719F016B47946C56" modified="2014-06-11" version="1">MSSNEAPRGGSGPLFAALAVTGVVASLAWAARDIPSALGARPTGARLERIRQSPRFRDGAFQNEQPSPLAAVPGGRGMIGEMLFGRQQRRPRKPVPIVTPSVTEPASTGLRTTWLGHATVLLEIEGRRVLFDPVWSERCSPSSLAGPRRLHPVPLDLAALPAVDAVVISHDHYDHLDETSIRTLTRLQEAPFLVPLGVGAHLERWGVPGDRIVELDWDETATIAGLGFTATAARHFSGRLRSDNATLWASWVVAGVDRKVFYTGDSGYFEGYETIGAAHGPFDLTLVQIGAYAPYWPDIHMTPEEGVAAHVAVNGGLLVPVHWGTFNLALHDWSEPVERLLTEAEECGVLVAVPRPGEAVDVDAPPKPDGWWRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABV1</accession>
    <name>A0A011ABV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3308305_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="39" mass="4512" checksum="7F0F206181B10F8F" modified="2014-06-11" version="1">MMLAILVFAVVIALLAQRFGVDSRDGMDWRPYEEASQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACX0</accession>
    <name>A0A011ACX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848679.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072321_0_0_11"/>
    <dbReference type="OrthoDB" id="1286900at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="35592" checksum="9E84BC83D09ACEED" modified="2014-06-11" version="1">MSRDIVGSSGASHVRIARRILVSLAIGATTYGLTSLADATSSNDAALTALTLSVFLGGAVLVVQFLMEIDGRLRGLEVRQAAHESRVEGVVQGAFAQINEAARLFGLLEETAARSDAVTQMVRHAILIKPSQPGVVYDFAQSEIGRTSSFLKALAAGEATYEGEDRDWLIGLTDCTRSHIDATSFATVDAGGESFSDGFWHTPLGRRYLKAQSDAVHDRGVTVRRIFIFDKPDFDADSDFRDICAMQVAAGVDVRVLEHNRINQSLMDLRDFILFDGGVSYETVVSASQRAFASPSILNTKLVLDIGQIRKRVADFEYLWSLGEPISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD26</accession>
    <name>A0A011AD26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569764.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495797_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="309"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="535" mass="57541" checksum="AB3A26AA9D360E9F" modified="2014-06-11" version="1">MAEVTDGGVAAGRAVTVGAAARAAAPSARPEPRLVRGSERPELFRAVVEAARAAVAIVYPDGSWTALGDTFTRGLGHSADLPARTRLLSLIHPADRRSVLEAFRAARDGREPAQSIPVRVRTAQGSWLELATTVRGRVHDPDVGGVVYYGVEVGRARDAERALSETDEGLERLIETLAVGILLVDGGGRVAVTNRALIELFDVPGPPHRYHGTDARALLRRMAGAMRAPDRVADRLDRLLAEPWTALDTDLMLVGGRVVEIDVVPVGAGGGALLHAWDVTARANAQRSLEERNEALSALVAAKNEFVASVSHELRSPLTSVVTFSNLLAQPDWGELDDEQRQFIEVIQRNADRLLRLIEDLLLLSRLEARTLQFVPSRVILPDLVRSAVAERAPIAQAADVTLKAEVSGDAVMSCDELRVNQVLGNLIGNALKFTPAGGQVTVRCHPAADGWRLSVTDSGIGIPSEDLDRIFEAFHRASNVEKHSHPGTGLGLVISKAIVERHGGLMEITSELGRGTTVAVWLPQRRVGDREGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD45</accession>
    <name>A0A011AD45_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848739.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140929_0_0_11"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14166" checksum="34BC07B988827530" modified="2014-06-11" version="1">MTLTLEDRLAITDLVNRHGHLTDAGDFDAYRELFTEDVVYDVSDLGFGAIEGLAATRAAAEALGEHNPLAHHVTNVVVTAVGDGARALSKGFGLMTSGAVGSVTYDDVVVRTDRGWRISRRTVKARREPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEN3</accession>
    <name>A0A011AEN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849408.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1547"/>
    <dbReference type="HOGENOM" id="CLU_1958413_0_0_11"/>
    <dbReference type="OrthoDB" id="1690796at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14035" checksum="563B8F1A87BE109B" modified="2014-06-11" version="1">MSLDVPTALLERAERGEATDAEFVDCIRTSLPYAWSVVTGVIADLESGTAPFADDSTPPPTEAERGQLLRALASDAIRGGLERHFGVTLAFQNCHRVGAFRPEAVGGAEYQEFVSVRGQLLNQSPELRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFT5</accession>
    <name>A0A011AFT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850013.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1950"/>
    <dbReference type="HOGENOM" id="CLU_027938_4_0_11"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="236" mass="25808" checksum="5F76811C440FBF5A" modified="2014-06-11" version="1">MFYWVCKYILIGPFLRLFFRPVLEGVENIPASGPVILASNHLSFSDSFFLPLMCPRRIVFLAKSEYFTGKGPKGLFSRLFFSAAGCVPIDRTSGSAAEAALVTGARVLGEGQPLGIYPEGTRSPDGKLYRGKTGVARLALQTGVPVVPVAMLNTHHVQPIGRLVPKVMRVRMRVGKPLDFSRYAGMAGNRFVERSVTDQIMYDLMQLSGQQYSDVYAASVKNGSDATRRAQEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG28</accession>
    <name>A0A011AG28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850125.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2041"/>
    <dbReference type="HOGENOM" id="CLU_125463_3_2_11"/>
    <dbReference type="OrthoDB" id="1914857at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14119" checksum="4881A3333E1B5BD5" modified="2014-06-11" version="1">MFDTVTSSVIKTAMDGLAMRQRVTADNVANVNTPQFLAGRVQFEDALRQAVDAGAGFDGETRAAISRAALADEATQPSMARSLEPTRTDGNNVNLDHEVISNIDTQLRYQLMIRAMDDQYGAIRTVAAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG74</accession>
    <name>A0A011AG74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(FAD)-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850173.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_0_11"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="349"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="450" mass="48685" checksum="D853BA6FCB0D3699" modified="2014-06-11" version="1">MQRRAANISRLAPQKSLANLGPADRILIVGGGPAGTAAGEELRRLGFRGQIQLLCQDPGGSYDRPACSKGLITGTQRPKDARIGVTDKRWEINWSLGRTAVACDMNERVVWANTGEGFRFDGLVIANGARPMLNSMWSGHATPHIVHDIEDAWNIRVGLRTAEHVAIVGGGFTGTELACSIRGMGKNVTLIHPRNVVLNGVLDATAAELMTEEHIEDGIDMRLGRRVKAADRMGDKWQLTLDNGDRVNADMVVMTAGEKPSISWLEGTGIDTSDGVICDDALRVLDTDGNAVPGVVAAGALAKWPNYWMNGKNGRVGQWIAALEQGQQAARSLLAGDAASHPAILLPRYWSQQLGLRVQVCGDISDESDVRRLERRPGHRKTARNGVLTCHYRGRDLVGVVAINAPSEFVTVARELLYAKPRYELSAPRRPVEVPTGILSRDGRRLAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGZ3</accession>
    <name>A0A011AGZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEKHLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850513.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2324"/>
    <dbReference type="HOGENOM" id="CLU_115296_0_0_11"/>
    <dbReference type="OrthoDB" id="1728677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013978">
        <property type="entry name" value="MEKHLA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08670">
        <property type="entry name" value="MEKHLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEKHLA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="16006" checksum="05FD6AE07604CF12" modified="2014-06-11" version="1">MDNLAELLTSSYATLVGGRLVPDEVSDVAAWLYDAPFGLLAHDTSPDPVFVYANRTAQEHFEYGWDEFVGLPSRLSAGEEDRNARAALLDAVRRQGYTDDYRGPRVTKSGRRFWIDDVTVWNLITPGSERVGQAALIRRWSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH27</accession>
    <name>A0A011AH27_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">CryarDRAFT_2411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850585.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2374"/>
    <dbReference type="HOGENOM" id="CLU_091257_0_2_11"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG81301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="17999" checksum="0DC189A96A057546" modified="2014-06-11" version="1">MRVLGVDPGLTRCGVGVVDGAPGRRCGLVHVDVIRTPADAELGHRLMAIADALAAAIAEFQPDYVAVERVFAQHNVRTVMGTAQAAGLALVAATRAGVPVAMHTPSEVKAAVTGSGSADKAQVGTMVARILGLSAMPKPADAADALALAICHLWRAPQQARLAAALERGRSRAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH35</accession>
    <name>A0A011AH35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850595.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2385"/>
    <dbReference type="HOGENOM" id="CLU_030571_5_0_11"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="23533" checksum="0C205D3476DEECB3" modified="2014-06-11" version="1">MLIAGFPAPALGTNCWIVAPAAGEQCVIIDPGIGVVDQLEDVLTEHRLHPAAVILTHGHIDHTFSVAPVCGAKDIPAYIHPADADQLADPWSYIGAPKGTPMFGLEYTEPSDVKALADGGTITLAGVEITTTLAPGHTPGSLVFGVRTPDAPVLFSGDLLFAGSIGRVDLPGGSAQAMLESLKNVVLPLDDATVVKPGHGPDTTIARERAMNPYLLQVATDLPRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHH6</accession>
    <name>A0A011AHH6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850813.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2554"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="28123" checksum="D4F216C43BDA4239" modified="2014-06-11" version="1">MGRVEGKVAFITGAARGQGRSHAIRLAEEGADIIAVDLCAPVRNVPYPAATPDDLAETVKLVEALDRRIIATQVDTRDRSALKTAIDAGVAELGKLDIVVANAGICIIGGWDQITPEVWQDTLDVNLTGTWNTVQLAAPHLVANGGGSVVMTSSAAGLKGLPFLTPYVASKFGVTGLGKAFAHELAEHNIRVNTLHPTGVETPMGSSEGTSAFGELLAAHPTLGGMLANSLPIETTQPVDQSNAVLFLASDEARYITALSMTVDAGNTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHI7</accession>
    <name>A0A011AHI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_2601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2564"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="117"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="473"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="506"/>
            <end position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="717" mass="75635" checksum="488C017026D8E61E" modified="2014-06-11" version="1">MTGPNGSRPNGSGPNGTSPDGGGGAAVPGAMAGAEAPGGAGVGTPDGLAAPGGPTGADSGVATAVGERPSAARGPGGAPGPGPARFMSGPGEKALDFKSSSRRLLATLRPERPLMGLGLALAAASVALSVTGPKILGHATDLIFAGVIGRSLPSGVTKDQAVEALRDRGENTMADLISHIDVVPGQGIDFDAVGRVLLFVLGIYLVASLFALLQGRVTTTIVQRVVYRLREDTQSKLARLPLNYFDRQPRGEILSRVTNDIDNLAQTLQQTLSQVIISLFTIVGVLSLMFWISPLLALIALVTIPLSTWVAGVIGKRARPQFIGQWSTTGKLNGHVEEAFTGHALVKAFGRQDETRQVFQAQNEALYQSSYRAQFISGLIQPAMMFIGNVNYVLVAVVGALRVASGALTLGEVQAFIQYSRQFSQPLTQVASMANLLQSGVASAERVFALLDAHEQDPDPETPSTPERVRGRVEFEHVSFRYVPDKPLIDDLSLSVDPGQTVAIVGPTGAGKTTLVNLLMRFYEVTGGRITLDGVDIASMSRADLRAATGMVLQDAWLFGGTIADNIAYGSRRDVTQAEIEEAAVATHVDHFVRTLPDGYDTVLDEEGSGVSAGERQLITIARAFLAEPAILILDEATSSVDTRTELLIQQAMSSLRQGRTSFVIAHRLSTIRDADLILVMENGSIVEQGTHTDLLAADGAYARLYSAQFAQPVADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIN6</accession>
    <name>A0A011AIN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570220.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083369_1_1_11"/>
    <dbReference type="OrthoDB" id="1394285at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458714" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="23702" checksum="4F63BC90F917C22C" modified="2014-06-11" version="1">MVCRRWGRVAFAALGVLGVVLATVQPGAAAVRSDDPPPGQFTMEVKRVHGSGCPPGTTTVVGTEDKTAFSLTYSNYTAQSGGGIATSQRRQQCVVTVGVGVPHGYTFGVTRTTFRGYADLAEGATGRLDTQYWFVGLPLTGLIRRELSGEYRDNWQATDDVPLPEVQWMPCRRGMVPLNIETSLAVDAGRMNPDTTSLMTMDATDSEVTTIYNIAWREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ37</accession>
    <name>A0A011AJ37_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3123"/>
    <dbReference type="HOGENOM" id="CLU_280844_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="124"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122344" checksum="59DBDAEEB4C40D4D" modified="2014-06-11" version="1">MKEGLEDQAILSLALVHHPVGTRIRVELSGPCPAVVENPFPSPITDLDRDAFRWLAEDYLQLRGPSADRIAEREKARIDRLAIELSRAIFNGPGLTSIRAAISHPASIAALRVEVRTDDRDPWVPWEIIPGPGSEIPLSIQAASFVHTSAQSQVSKNANPASGKLEVLMVVSRPEGRQDVPFRSIASRVVRTIGKPGTEVNVRMLRPPTWSALKSELEAAARNGIKYDAVHFDGHGLFDESKSDDSSSRGYVLFESETAEGGADRVDGRTMGELLTKYGIQSVLLNACRSAYREQDSSALENRTADSFAAELLTAGVRDVMAMSLSIYVSTAARIIADVYDRLAAGETLVGATQIARRLEFQRNPTHETQPLGWAVPIIYQGLTLGGQSASDLETTHNNRQIKNLGEHGQSRAIDADLDFIGYDGEFLSVDRALTRTARARITGLAGSGKSSFVREFSNWAVATDLAQEAHVVELEQGLMESMRIMRAHLHQKEVSRVLIAIDGINDEQGHRRVTNFVENVEEFFGIERGVVYVILSGRATVNSRAENVIALNGLDPISARDVAVRSGWIDRSVPDFEKWLDWSRGLPAVINALPDFLSTRSLADANSSETRSLAQIRAGGPASTDDAATILKQFSLKRIEPATITSAAVPIAAALFQSHLTEFEWDLFRQLQERNGFAGLADDLGNLFPSQIDLFSSLGLVSVQEDGSAALHPLASIAARDAHDAVLDFIAEGTSLDFPDLLRNHWATFTMTISVAERVRSQTGSENEEVVLGAAENVWRALDISIAGYWWEHAFPLLRALRRRLLDQSRLSEWESAFQEADLNFKSTPEDALRPGVEDPHVLYFRLQADEAHRRKDFAAEAQWNNKALARTFSAEGQTIAVDDNPRMRNNRFITANMRRGDELRGVGSPECLTWYHKALQLAEGDPLRSADAYLGIARAYFNVPALRNSVLYEKYARSALAAALPMGNIAGDLLSSCCLSVGSAIWESIKSSPDANNAQRVEEAVYYLDLASEGAVPNIAASAHNNVGTIYLDLEMGDLGAARFLQACALLEMLGELGTLALARTNAAIALFRKGRVAHARDLAQAALELQDQASDQVTRVRSILEYILAEDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALK3</accession>
    <name>A0A011ALK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852738.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3965"/>
    <dbReference type="HOGENOM" id="CLU_028880_0_2_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="35086" checksum="6F782C4573453D26" modified="2014-06-11" version="1">MLGIATTTAAEEFARRRQSPLQRVQHVLHGHPSLSPLIVLVIAFAVFSALNPRFAQPASLSLLLQQVAVIGALAVGQTLIILTAGIDLSVGAVTILAMMVAAKLAEDGGIPGVLAVLVALALGVVAGLINGALVTRISLPPFIVTLGTLSVFTAIGLLYTSGQSVQADALPALLNWTGESFGVGRWRITWGVVIVVLLYLGVGFALANTAWGRHVYAVGDDKEAARLAGIRVDRVLLSVYAVAGAIYGLTAWILIGRAGAASPNAITDANLESITAVVIGGTSLFGGRGALLGTLLGALIVGAFRSGLSLAGVDDQYRVLAVGLLVIVAVGVDQWIRRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALN0</accession>
    <name>A0A011ALN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative low-complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852804.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929741_0_0_11"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="299" mass="32639" checksum="913C2A10FF0A1BD8" modified="2014-06-11" version="1">MLPCVRRWHSESARHVVERLAAGRSLDDLGLATVDGLLDLRGLPAAGLVVTGARLTGLDLSYASLPEARLTDVEWRQCRFDSVDLSAAVIVGGSLAESTVRRADLRDTSVAGSSWESVDLVGSKFAYFAAERVTFTHTTFPALASVGFTRCSFERCRFLGGLSGVRFLGRQTRDDRAPAVLRGVSFFSDNLRYAEFDGMEFDDVTFPGSDAIIVVEHGFRAVAERAGDLSMNRRDDVGEAFRKFLSLESSRPGLSATAGWAIGRRDFIDDHPNGPELADFATRTLRKAQKQLRSEGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFS9</accession>
    <name>A0A010YFS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Raf kinase inhibitor-like protein, YbhB/YbcL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847522.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.98"/>
    <dbReference type="HOGENOM" id="CLU_083918_2_1_11"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="18788" checksum="C99C33A708BF4544" modified="2014-06-11" version="1">MALERPQAPDPYALLPEVPSFTVTSTDVTADTQLDLAQVAGDAGGRDVSPQLSWSDFPAGTKSFVVTAFDPDAPTPSGFWHWLAVNLPGTTTELPTGAGAGDDSLPGGAFHVRNDYGNRNYGGAAPPPGDQVHRYYFVVHAVDVDALDVTPDATPAVVSFNLAFHTVARALIVPTYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFX9</accession>
    <name>A0A010YFX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569552.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.151"/>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="31"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="35650" checksum="D5173C8DD6F6699C" modified="2014-06-11" version="1">MIQLLTPDGVRRDDDNFPLDVTHDELRGMYRDMVVTRRVDAEATALQRQGELGLWAPSQGQEAAQVASVRAFAASDMLFPSYREHGVALARGVRPAELLSLFRGASHGGWNITERRLNTYTIVLAAQLLHAVGYAMGVQRDDAREVVGVYFGDGSTSQGDASEAMNWASATDAPVVFCLQNNQYAISVPVGKQSPVPLYRRAEGFGFPGVRVDGNDVLAVLAVTRWAVDRARAGEGPSLIESFTYRMGPHTTSDDPRRYREPGELEHWRALDPIDRLRRHLDAEQLADESFYTSVEEDATTVAAAVREACLGLEPTGPFPVFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG56</accession>
    <name>A0A010YG56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="20622" checksum="4AC6CF6A46A335CE" modified="2014-06-11" version="1">MSSRRDDLLDSAEDVFCRLGYARTTIGELASAAGVTRPTIYAYFPSKDDVFRALADRVRLEFLALQEKADTSSPERTVREALTAFLAAYTRHYGVLTVIAHQALADPAMRSLRDEMFARVERRNARFLERLVAAGLADPAIPGADLARAVTGLTARSAERAFESPSELPTLGEQLVRCYLRLAGIADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGD4</accession>
    <name>A0A010YGD4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.302"/>
    <dbReference type="HOGENOM" id="CLU_058793_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="103"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="25657" checksum="AEBF3FAF1F181CD1" modified="2014-06-11" version="1">MTGYGLSVSDPLAPLLDLPDVADAAAEARKQIDQLFGHQLLRRGSGPVSVEAALRGAHASAALEGARYDLESIRAGAVTDPVVQGSLRVAGALGSLVDTWSKAPLQVLARLHVLAARDVLPSEALGRPRTDPEVAARLSALSDLVTGGTEAPAVVLAAIVHGELLVLAPFDGPGGLVARAAARLTLIAKGLDPKAVSVPEAGHLAREPEYIGATNAYATGTADGVRSWLKHYCAAVALGADEGFAICEAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGQ7</accession>
    <name>A0A010YGQ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848113.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.475"/>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_11"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="31386" checksum="7CEC2F5A94920F55" modified="2014-06-11" version="1">MRVVIALGGNAMTSADGRARPEDQIAAIQRAAGPIADVVASGAEVVLTHGNGPQVGNLLVKNEMAAHVVPPVPLDWCGAQTQGTVGFVLLNALEAAGAPVAALVTRALVDIHDPGFMNPSKPIGRYLPSAEAALMIQHGQRWEDRGERGWRRIVASPEPRAILEAPAVSSLLEAGYVVVCNGGGGIPVVREPDGRLRGVEAVIDKDLGAALLAHTLNADTLVIATDVSAAVVGWGTASARPVGEIDVTALRTLATEGHFASGSMGPKVEAACRFAENGGRSVITSLDHIADAVHKSVGTVVTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGW1</accession>
    <name>A0A010YGW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1914661_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="17289" checksum="5DA0554F1DC18C7C" modified="2014-06-11" version="1">MAKSEAGWVLLAGWRRWRERRRRHKRHHHGRRANALDGCNCDGCDSCDGCDGCDCNFNLFSLGTLLLLVPFLRATPDLRPRTTAAGRGGVVLIRGYQRLLSKHLPTQCRYTPSCSEYGAQAVRRYGLLNGSRLIATRIKRCTRGVPLGTPDPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHW9</accession>
    <name>A0A010YHW9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569736.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064500_0_0_11"/>
    <dbReference type="OrthoDB" id="1473120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32534" checksum="5D322F3E86472D7E" modified="2014-06-11" version="1">MLFNGVKVALLLLMLGFAAWYLIDNWPEVSRALRQLSTALAVASIVPAVLAMVCGMFVWRSLLADLGSRLPVLVAARIFFLSQLGKYLPGSVWSIATQIELGRAHKVPRRVSLSVGILGLALVVAVGFPIAAVLLPLGAPDVLGRYWWGMLAVPFVLAALHPAILGPLADLAFKILRRPPLPKRPSGRGITIAAAWQAGVWFFFGLHAWLLLVGFGAPPLRALAVAIGGYSLAYSLGMLAIPVPAGAGVRDIALVAAFSAVVTVDQALLVALVSRVILAAVDVGLAGGQYLVTARKVAPPPADELANTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIB3</accession>
    <name>A0A010YIB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848766.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1041"/>
    <dbReference type="HOGENOM" id="CLU_140176_4_1_11"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="81" mass="9346" checksum="A48C8788BA12DBB4" modified="2014-06-11" version="1">MATDRFLQLSDVAEILNISSSQTYALVRSGDLPAIKIGGRGQWRVERAELEHYIERMYKETREFVRAHPFTYSDAPEEEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJB8</accession>
    <name>A0A010YJB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484614_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="562" mass="59716" checksum="1535F6B5EA13DA61" modified="2014-06-11" version="1">MLTDPRSVGPMRTDPRLIDPPRTDPRSVDPVPVPAPTVRTDPRSVDLAPAPTVRMVLCSAVPVLMVRMVRRLVAPGPTAPVRTGSGVLVLMGRTGRSSVGGRARMGRNRRSGGVDPAATVRTGSGRLGLGRSVLCLRGRTRVDRCHGRRTSVGRTGPVGRFLVPLTSVLPPGWEPRRRGRPRSGFRRKRRMLSSGVRMASGVASGRCRRPRPAIGTGAIGAGDPTSGGRLGPRPAARRSAALKRAAPKPAARSSAIWVRTGPRLLVRVRTDPRSVVRGRTDPRSVVRGRTDPRSVVSDRTDPPSVVRGRTVRSADLVRTTAPSVVPGPRAPSEARRFRVGPCSAVRPPVGRMVGSAVRKEGPFSGARRDRTARSEGRPWAGLTVRSEGRGPVDPCPADRGAMAPSAVRARTDRPSVARPRAARCSVVRRRTVPPLAARRRTVPPSVVRRRTGRPSVVRLRAVRPWVVPPRVVRPRVVPVSSGPRRPVDGPVLRSGRLDPATTIANSATAHPATATPEAKTPATHGTAIPATKTVANAGTTTINRPRSVAARPSSGTPAPTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJH9</accession>
    <name>A0A010YJH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849241.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1437"/>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_11"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16823" checksum="9321E5F3DA4DF35A" modified="2014-06-11" version="1">MTENTVTIEPRISAAQLAPDGYRAVLALEKYVASNVEPVVFELVKLRASMLNGCSFCVDMHSKDALAAGEDSRRLFAVAAWREAPFFTRRERAALALTDAMTRLGEHGVPDDVYAGAAAVWEEKDLADLILAIGTINLWNRLAITSHTPPPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJR1</accession>
    <name>A0A010YJR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_11_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="133"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="30402" checksum="082EE2399B4C870B" modified="2014-06-11" version="1">MVFVGGSVAVSSLLVGSPLFTVQAVRYALACVLLIGFARLAGQRLVRPRGAEWLWLSGIAVTGLVVFNIALVQGSQHAEPAVLGVAVASVPVLMAAVGPLLEGARPSVRALVAALVVTAGAGLVEGLGRSDGLGLLWAVVVFASEAAFTLLAVPVLGRLRPWGVSVHTTWIAAVAFLVIGVVREGPTAVSEFGRAEVGAIVYLAVAVTALAFVLWYTCVAHLGSSRAGLLTGVAPVSAALCGVMLGQPVPGVLVWVGIAVVAAGLAIGLPSRSAPAGGLEVGPVGPDPAAADPLVDQAAGCRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK32</accession>
    <name>A0A010YK32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="16667" checksum="664CE7ECE71ADE7E" modified="2014-06-11" version="1">MVRRDEVTEAAWERIAPLLPVSAGRGGRWKDHRQVLNAIVWKLRTGAPWRDIPDRYGSWKTAHERLRRWSADGTWDRILEHVQVHDDAVGEIEWTFHVDSSVVRAHQHAAGARRPQAATKGAASISAAPRVRASRSLRSMKRSGGPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKV3</accession>
    <name>A0A010YKV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1919"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="376" mass="38151" checksum="873BD64BF9965CD8" modified="2014-06-11" version="1">MPLHPVAKQALAAALEDGWADPARLYTEARRAGQLLDAARAVVAEVIGARPDEVTFCANGTVAAHLAVLGGLAGRRRAGSVFVHSAVEHSAVLHAAEQHDAAQQAAGTTGTSVPVGVDRAGRVSTSAFAEAVRAPGVALAALMSANHEVGTAQPVSEVAAACASAGVPLFVDAAQTLGRAPVPGGWSLMSGSARKWGGPAGVGVLVVRTGTRWTTPYPADERERGRFAGASNLPAIVAAAASLRAVHADAAAEAARLGPLVDRIRERVAATVPDVEVVGDPVDRLPNLVTFSCLYVDGEALLHALDARGFAVSSGSSCTSSTLSPSHVLEAMGVLSHGNVRVSLHSGTTGAEVERFLTELPAIVAELRATAGVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL17</accession>
    <name>A0A010YL17_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_2025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1990"/>
    <dbReference type="HOGENOM" id="CLU_009629_3_1_11"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="46"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="515" mass="51971" checksum="50A8160916F698FF" modified="2014-06-11" version="1">MTLPTIGRFPGVGTGTGSTGCGTMGFVLFEDRFTRPPHVVVIGGGIAGLSAALRLRDAAPDGTTVTVIEQAGSVGGKLRTGRVAGVPIEDGAESFLLRVPEGKALAERVGLGADLVSPTASGATVWVDGSLRALPAGTVLGVPVDLEAVAASGVLSEDGLARVRAEPGRPGTPLGDSDVAVGELIADRLGSEVVDRLVEPLLGGVYAGRADRLSLRATMPALAAGLVDQPSLLKAARANRGRAAPNTPIFGTVRGGLSRLVTAVAHESKAAIRTGLPVRSLRRTPDGWQLTVGSAGSAGRSGSTTIHADAVVLAVPASPAARLLGDVDPVAAATVGVLEYASVALVSLVLPGRVALPPGTGALVPASSGRLVKAVTYVSQKWAHVLDGYTGEPVTVVRASVGRYGEEAVLQRDDESLIDAVRAELATLVPLAAGWPAPLGVQVNRWGGALPQYAPGHLDRVASVRAALAAEPTLALAGAAYDGVGIPACIRSGQAAADRILAALQATRRGEPVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLC6</accession>
    <name>A0A010YLC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation transport ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873503_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="33785" checksum="69BB8D696693C680" modified="2014-06-11" version="1">MRPAVKASAETRGPVSVHPWAYPHEEVVRRFDVNPLTGLTLEEAARRRGALGPNVVEPGTEEPAALSQERWPRLRAFVDTLLGRRSEAEAETEEVREQFMARVLRSDRVLSVHAVDLVPGDIVLLAQGDLVPADARLLDVVELRVDEEPLTGGELASSRCVAPVGSGWTPVADRRSMVHAGSRIVHGAGTAVVVATGPLTVIGRATLNRITSSQRGTLGRARNARRPGGLGRRGGLGAGADRRAARATESAAPAGIPWLPSAAPPSRTLPKPLSVEATAPQPTLPAVRPAIGPRPLVLGPRPARAARSARRWTRSCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM94</accession>
    <name>A0A010YM94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850614.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2404"/>
    <dbReference type="HOGENOM" id="CLU_118048_0_0_11"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17404" checksum="0C2606BD7BF6EEC2" modified="2014-06-11" version="1">MSDYAKALGARLRAIRQQQGLSLQGVEEKSGGRWKAVVVGSYERGDRAVTVARLNELAEFYRVPIAELLPGDGPGRHEGASKVVIDLERLEQLPGDELGAVQRFARSIQQQRGDYNGRVLSIRADDLRTLAIVFDLSPAGLIEKLTEWNVLVATPIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMC3</accession>
    <name>A0A010YMC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="28145" checksum="06D4B407DE2D26B9" modified="2014-06-11" version="1">MTRPEDPPLASGRTPRVAAARRLTRRSRRDDVGQFLAEGPQAVREALALPPGAPGAPSLVFGTTAALRRYEQLVAGASVPVVPVDEAGMAGLSETVSPQGLVAVCSFLDVPLSAVSGPLVAVLAEIQDPGNAGTVLRTADAAGAGGVVFTDGSVDPYNGKCVRSSAGSLFHPPVVRGVAASEAIVSLRDAGLQVLAADGYGEDDLDDLADAGELSRPTAWVFGNEARGLPDSLAALADRRVRIPIHGRAESLNLAAAAAVCLYTSARALRFHSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMQ5</accession>
    <name>A0A010YMQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2583"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="28202" checksum="2228C42AA176230C" modified="2014-06-11" version="1">MRAAEAGNGLRMNIDLSGRRALVTGSTQGIGHAIAAGLAAAGAEVLVNGRSADRVEAAVASIGGANVRGVVADVASAEGCDAVSEAAPDLDILVNNLGIFGAKPVLEVSDDEWRRYFEVNVLSGVRLTRTYLPGMMDRGWGRVMYISSDSSVVTPVEMVHYGVTKTALLGVSRGFAKAAAGTGVTVNSVLAGPTHTGGVEEFVSELVGDDLPWDEAQRQFMREHRPQSLLQRLIEPPEIANLVAYLASDLASATTGGAVRVDGGYVDAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNC6</accession>
    <name>A0A010YNC6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570151.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2767"/>
    <dbReference type="HOGENOM" id="CLU_013985_34_6_11"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="161" mass="17523" checksum="57B8F79AA33CB285" modified="2014-06-11" version="1">MIRELAQISLSSGTVVLRRAEKPDLPTLVEFLAADQLGAHHENAEDLAPYEAAFAAIEADPAQLLVVAIVDGRIVGTFQLSVIPGLARRGSLRAQIEAVRVSDGYRNRGIGAAMMRWAIEEAGRRGCALVQLTSNKARLDAHRFYENLGFARSHDGFKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNN4</accession>
    <name>A0A010YNN4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_2880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851195.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2842"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="44"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="361"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="597" mass="63831" checksum="A6A550B026DCBBD7" modified="2014-06-11" version="1">MATATAPGRRGPQKLSEAEKAQARTVSLRRIARLFRTHRWQLTVVTAIIVASSVVSLASPFLLREVIDVALPTQNLRLLVWLVIGMVAVAAVTSAFGVVQTWISTTVGQQVMHRLRTEVFTHLQRQSIGFFTRTRTGEVQSRITNDIGGMQTVVTSTATSIASNLTTVIATMVAMVALSWRLSLVSLVVLPPAIYLTRRVARMRQAITAQRQRELADLNVTIEEGLSVSGAQLAKTMGTGGVLVDRFTASSSRLIDLELRSELAGRWRMATMSIIFAAIPAVIYLSAGLPGTTGTLSIGTLVAFTSLQGTLFRPLTGLLNTGVSVAASLALFARIFEYLDLPVEVADPVAPRDLPSAEGHLRFEDVTFTYPGNDVAAVAGVSLDVPAGTTLALVGATGSGKSTMAALIARLHDPTGGRVTLDGVDLRDLRLADLSSIVGVVSQETYLLHTSVRENLRYAKPDATDAEIENAARAAQIHDLIVGLPDGYDTTVGSRGYRFSGGEKQRIAIARTLLRDPRVLVLDEATSALDNTTERAVQKAFDALSAGRTTVTIAHRLSTVRDADQIAVLDHGRIVEVGTHDALLARSGRYATLALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRB7</accession>
    <name>A0A010YRB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852668.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3906"/>
    <dbReference type="HOGENOM" id="CLU_028880_0_1_11"/>
    <dbReference type="OrthoDB" id="2027746at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="31344" checksum="7FA6BDFF3D06B291" modified="2014-06-11" version="1">MSTIVAGRRLSPPQWTDVLAGAALLALLAVGASTERFLTVANVKAILTSASLIGIAGLGLTLIVIGGTSVSLAISQSVAVSAMVFLAVQSAGLVVALVATIVVGALITGLQGLVVGYGAANPIVLTIAAGFALTGLATGIGGGTSVSPTGTGYTVLNATPGGIPLSVYALVLLTVALQAVLDRSAFGRQLYLTGENRPAARAAGLPVGRVVMVAWVLAGALFAVAAAFSGAFNTSANINLGGTLTFDAIAAVLAGGTPIAGGKGSAWRTLAGVLLIATVSDILLLRGYGTGAQIMVKGLIVLAVIVVVHLRTTRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV55</accession>
    <name>A0A010YV55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional attenuator, LytR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="120"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="39411" checksum="683F957FF78F3685" modified="2014-06-11" version="1">MARTEPPASKPRVTRGTVYGAPGANPAPRKAKPRWGRIALLIGGLAAVIVLVVAGCGYAYVTNLDEKLHRTDAFSGLDDRPGKSVAGAQNILFLGSDSRDGADYDPKGSPKTGAAGKNERSDAIMVLHIPADHKKAYVISIPRDTYVSVPELDGHGGARAKINAAFSWGGIPLTVKTVENFTGVKIDHVVKIDFNGFKDMTNALGGVDVTVNKTVTDPRSKRTFKAGVNHLDGDAALDYVRQRYGLPNGDFDRVQRQQIFLRALMQKATDSGTLSNPVKLKSFLDASTKSLTVDNDFSLKDMALEFRGLRPGDISFITSPHKGSQTIDGQSVVVSDKEKAIGLWGAVEKDTVADWLAANPANNATKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVE7</accession>
    <name>A0A010YVE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847578.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.138"/>
    <dbReference type="HOGENOM" id="CLU_009100_2_2_11"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458909" evidence="1">
        <location>
            <begin position="24"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="400"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="55586" checksum="E343FF1748725704" modified="2014-06-11" version="1">MKRRRFLGLTGAAAGAIALGGCAAEGSTGEALGSDRPLPAPFRVPLPIPPVKRPARRDTSTDWYEIVQRPADVEILPGVRTRILGYDGVFPGPTIESRSGRRTVVRHLNHTDVPTVVHLHGGHTPADHDGWPTDLVLPRAGGDHHTHHRAGHVTRGRRDYVYPLAQPAATLWYHDHRMDFTGPQVYRGLAGFHLIRDDVEAALPLPDGDRDVPLMITDRAFDADGALKYPAADHAAGTHDDFLEGVLGDVVLVNGAPWPELEVDAVRYRFRVLNASNARRYQLTLDQGATFVQIGSDAGLLAAPIEHRSLTVAPAERFDVIVDFSGFRPGALITMRNPLGRAGAGRVMRFRVARRARDDSTIPAALAEIPRLTPPADAPRRRFAFSRGIVPDGLGGERKGWVINGKPFDPSRVDAAPRLDDVEIWTLSTDLHHPVHVHLSPFQVLSRNGRSPGDFDAGWKDTVDLRPAETVEIAVRFTDYRGRFLLHCHNLEHEDMTMMSTFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWI5</accession>
    <name>A0A010YWI5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2878334_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="63" mass="7112" checksum="B4BCE7DE11E512EB" modified="2014-06-11" version="1">MSNDYLEYATVYFWDESGSFSAESERTSTAAHRPYPGRRSSATKNRRCGGARPATSETPRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXL8</accession>
    <name>A0A010YXL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">CryarDRAFT_0996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848712.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.979"/>
    <dbReference type="HOGENOM" id="CLU_005122_2_2_11"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="675"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="861"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1210" mass="131113" checksum="A98BB75474A294A8" modified="2014-06-11" version="1">MSLSGLLDASLADPALGQIARRAAGDAAGELDLTAPEALRPFVVAALAAARAKAGSAAPVLAVTATGREADDLAAALTCLLPPDRIAVYPAWETLPHEKLSPRADTIGRRLAVLRRLAHPSTDDPTTGPLDVVIAPVRSVLQPQLAGLGELEPVGLQAGDTAPLDAVVERLVSIAYARVDLVEKRGEFAVRGGILDVFPPTEEHPVRVEFWGDEVEEVRYFAVADQRSLEIAAHGLWAPPCRELLLTPEVRERAAQLAKDHPALAEMLDKVADGIPVEGMESLTPALLEGSGQLELLVEAVPAGTHVLLCDPERIRARARDLVATSAEFLEASWAAAAGGGEAPIDLGAAAFRSLADVRSTGTGRGLPWWTVAPFGVSAAGSASAADFDDDAIDVAIPAVADPGVPRDSLTVEAKSVDGFRGDTGRAVEELRQRVAEGWRAALVFEGPGSAQRAAEMLREADLGAQLVVDVPTAPEARSVLVTTGQLAGGFLLESAQLVVFTESDLTGARSGSGRERGRMPSRRRNAVDPLQLQPGDYVVHEQHGVGKYIEMIKRTINGGEREYLVLEYAPSKRGHPGDRLFVPTDSLEQLTRYVGGESPALHKMGGADWQKAKGRARKAVKEIAGELIRLYAARTSTKGFTFSADTPWQRELEDAFPYIETPDQLVAINEVKADMEKPYPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTILAKQHFLTFSERMAQFPVKIAQLSRFQTDGEAAETVAKLATGEVDIVVGTHRLLQASTRFKDLGLVIVDEEQRFGVEHKEQLKQMRTAVDVLTMSATPIPRTLEMSLTGIREMSTILTPPEERHPVLTFVGPYEERQIGAAIRRELLREGQVFYLHNRVESIERAAARLRSMVPEARIAVAHGQMNEDALERVMLGFDEKEYDVLVSTTIVESGLDIPNANTLIVERADVLGLSQLHQIRGRVGRGRERAYAYFLYPPERPLTETAHDRLATIAQNSDLGAGMAVAMKDLEIRGSGNLLGGEQSGHIANVGFDLYVRLVGEAVAEYKGERTEIESEVKVDLPVDAHLPHDYIPGERLRLEAYRKLAGVTTSEELAQVREEIRDRYGNPPEPVENLFAVAAFRVKARAATITEVSLQGRQVRFAPLRLPESKVMRLQRLYPGAMYKQAVDVVLVPRPSTARVGGQPLRDTALLDWAAGFLDAMAPEPARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXQ2</accession>
    <name>A0A010YXQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848747.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1019"/>
    <dbReference type="HOGENOM" id="CLU_075053_3_0_11"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="24441" checksum="3269B45E0EC8CE57" modified="2014-06-11" version="1">MTAEPPPTEFWGLLKPSETEDFLALARPRSWARGAVIFRESDESDSVLVLVSGRVKAYSSTGGGTEVLLAVRGPGALVGELAAIDQRPRSATVEALEPVTALMLPLGAFQEYLRAHGRIALLLAQTLADRLRDADRKRIEFGAHDTLGRVAARLVELADRFGQPTEEGVRIALPLSQDELAGWIGASREAVSKALQTLRADGTIRTSRLTVVVHDLPALRARALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXV1</accession>
    <name>A0A010YXV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848795.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924085_0_0_11"/>
    <dbReference type="OrthoDB" id="1489314at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14277" checksum="996B1AAD2E589C02" modified="2014-06-11" version="1">MTPVVRLRQAADPAETFGQALARWRQSRGLSLRRFADLVHYSSSYLHELERGRKTGSLALARKLDDALDAGGELVALAPEQKPPMLPAALSGRPTVRPVAGRDGWMVLQVGDAVLVLEPAEVDALREQLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY82</accession>
    <name>A0A010YY82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1215"/>
    <dbReference type="HOGENOM" id="CLU_047691_15_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="26113" checksum="2A9344835EFF5E38" modified="2014-06-11" version="1">MTTLALPTSARRPRRWWGWLTRATPARTIAAAGRTANGPFEAAWPADARAGDARSRGTEPDELAWPPRRTAAAPEANGSKLVELYHHRRLALVRLAVLLVDDLPTAEDVVQDAFAAAYRRHGAAFSGVENPDAYLNTAVVNAARSVLRRRRTFRAAPPRFELSPATDEGLLLAEEHSEVLAALRRLPRRQREVLVLRYWSDLSEAQIAETLDISRGTVKSTASRALAALEKLLEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYB3</accession>
    <name>A0A010YYB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">alc</name>
        <name evidence="6" type="ORF">CryarDRAFT_1269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725669.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1250"/>
    <dbReference type="HOGENOM" id="CLU_038797_1_0_11"/>
    <dbReference type="OrthoDB" id="651058at2"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="176"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="366" mass="40370" checksum="14382855F389F412" modified="2014-06-11" version="1">MIDLAVRSLGGAVIAANDETFAEKENLIRPDVPLFQPHTFGHKGQIYDGWETRRRRSPGHDWAIVRLGAPGFVRQVVVDTAHFTGNYPEECWLEGRYVNGYATLDDDGWTPLTGRLPLTGDSANTFDVPDGPLVTHVRLNIAPDGGVARLRVLGDAVPDPRRLAGVPLDLAALENGGRVEDCSNRFYSPADNVLLPGQAQTMGQGWETRRRRGEGNDWLLIRLAGPGHVRQLVVDTTHFVGNAPGAVRVRAVDAERHDPLGDEGWVELLERQALLPDTPHWFATDPGVRATHLRVDVFPDGGLARVRAFGQLTSDGWDALVSRWRAGLPEALRDALDDTWEKHTIHRPVAPHNDSHDGPQGSLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYQ4</accession>
    <name>A0A010YYQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="105"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23154" checksum="2020CA59CC4EAFCA" modified="2014-06-11" version="1">MHAPTTTTEIVLSVCCTGRPELVVLGPRTRALYYEPNGNPVAPRFRLTAGQARAAFGMPVTEFTDQVVPLPSADAGQLAERWLAAPSRPGAVLEPYLAAAAPAADRETRWVDAAAARLAGGTPIAAVADDLGVSERHLRNRFAAAVGVSPKHYARIQRVRRVLDEIGSAPFAQLAAQAGYYDQSHLGREFRQLMGVSPAAFAAGRRPAPRTCATTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYS9</accession>
    <name>A0A010YYS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849234.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125367_2_0_11"/>
    <dbReference type="OrthoDB" id="1949020at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="126" mass="13225" checksum="C8EFBA2D30CA54A6" modified="2014-06-11" version="1">MSEPEETPESPRSGLKNPGAAVRGVGAATLLLEFLVLLLAIQPLRTLLPDASGAAAVLALVLGLLCLAAAGLLRRGWAWNAVIGLQVVIVATGIVHWMLGVVGGIFLLVWIYVLNVRKSVLGDRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ70</accession>
    <name>A0A010YZ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer DM13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849464.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089192_1_0_11"/>
    <dbReference type="OrthoDB" id="1551664at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM13" evidence="1">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="175" mass="19090" checksum="4C6F22F7451DA3F6" modified="2014-06-11" version="1">MFPRLLTWVLVPVLVAGAGFGLYWFQPWRLATDTTVADEVPVVATPTTSPSAGASPVGNRLVATGSFVTHEHETSGRVQLIERPDGRHQLVLIGLRTSDGPDLRVWLTDQAVRPGRPGWHVFDDGRYLEVAALRGNRGDQVYDLPVAAELDGLRSVTVWCKRFSVSFGAAELTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZA4</accession>
    <name>A0A010YZA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849484.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501102_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458216" evidence="2">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="18678" checksum="3CA8B9DA87E31678" modified="2014-06-11" version="1">MSSTVRSRTGRAAAGFALVAAGALATGCGGDSSPYVPDPAYATTAAPAPPTPVDETETAPVTALDVLLGVWSRSTDTMEVAIRFLPDGTYRSVEVYSPVESGGVYTLQRVEDGVAQVNSAALRLVGRTATVSRRATDDSGGDYDRSTPTRTGSYTWQVDGDELHLTDAGGVDAVFTRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0A5</accession>
    <name>A0A010Z0A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase and lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850003.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1942"/>
    <dbReference type="HOGENOM" id="CLU_128243_0_0_11"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="16367" checksum="D978471960E80E9C" modified="2014-06-11" version="1">MADSSQQSITIPAPVGTIAAVISDFASYPEWVDAVKSVEIVSEYEDGYTHQAKFVLDAGPVKDEYTLEYAYAEDLTRIEWTLVESTMMKVQDGSYDLVDNGDGTTEVTYTLTVDINLPMLGMFKRKAEKMIMDTALKDLKKRVESCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0L4</accession>
    <name>A0A010Z0L4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569992.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_2_11"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="18351" checksum="379F651021B9C1C0" modified="2014-06-11" version="1">MSLIIRPALREEIPTCAAIVAAALRDDPVVEVVVPRGPGDRLRQLTAFYTAGFLGGAFASGVVDTARREEDSPLLGVAAWIAPTDETHSRQPHRPEEPHWYLSDIAVVAAARRAGIGSALLAHRLGRIGGPAYLEATTPSSQRLYQRFGFEVVAALRLTPEGYPLAMLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0S7</accession>
    <name>A0A010Z0S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tfp pilus assembly protein PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116140_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="22430" checksum="16468426C159DFD9" modified="2014-06-11" version="1">MVVPAVGLRGEGSLFDPAALRISAYRSWLIGGVAGAVALILLGWFLLIRPQLNEAADFRERTASAEDGIAGLRRRLAEVRAENANLDSYRTAYTSARKALPTSGNVTTFLRDTQSAATLAGTTMKSITVGTPSALADGAVYGLPITVSTEGPASALDTFVHRLQRVQPRTVLVKTLSLTSAEETPVMSGRIALTIELQAFVAPGAATASESTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1H2</accession>
    <name>A0A010Z1H2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850505.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2321"/>
    <dbReference type="HOGENOM" id="CLU_000445_39_1_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="24315" checksum="11BE01ACAB740B5A" modified="2014-06-11" version="1">MITVLVVDDDFRVARIHCGFVEQVAGFAVVGVAHTGREALDAVAALRPDLVLLDLYLPDVFGLDVLAELRTSAHDCDVLVISAAREADAVRGAVRNGIVNYLLKPFGFDDLRRRLQQYAAQRAGLYATELENQADIDRALSQAARSATQALPKGLSAETAALVERTVRAAAVTLSAAECADRAGISRVSARRYLEFLRDTGRVTVTLRYAQGRPERRYRWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1R6</accession>
    <name>A0A010Z1R6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2437"/>
    <dbReference type="HOGENOM" id="CLU_424420_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458230" evidence="3">
        <location>
            <begin position="16"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="670" mass="70879" checksum="68E803028D4E785C" modified="2014-06-11" version="1">MATLFASPGVRPAQAACGPSDPAACLPSSSVVDCLDPPTPAMPDTGVSRFFLTAPGDTPGDGRLHATSRYDDYGYAGLQFHTYDLGCGPDGAVAPDALVNNSIANMMLGVATFVVGLTNSVREHAYDPQEMWGWTDDLVGSASGALYERLFTALGVVSVVIVGGWLLWSARRGDMSNAATTAGWAVLVMVVTTAIAAWPVRAASVADGALTGSLGAVNSALHPNKDEVCGTTRCVDDRTPQRQASGVVSEVVLYRQWLSGELGSADSQTAKKYGERLYAASAFTWQEAEEVRRDPTRREEIVKRKNQEWKDTAAEIKKSDQDAYEYLTGKQGTDRMGAAFTALISAAVAAPFDLISSILIIIAFLVIRLAVVFLPAIATIGIMRPASGPLRGLFRTVVAAIINCVIFGVGASVYLLALDLITSTASLAGWQQILLIFLTGLVMWLLLRPFRRLTSLAGGNPFHDLVGGLGAVRRRAFGDARTAGIAAAGVFIGNKAAEDDDKRSDARPESWSRDRSFVRVADSPAEAESATTFTRANAGGGRLSDESPVVMAGRSARPENGTTGSYAGAGSYSGTGRTDSDGDQITPAGARPPMRVPAGPARPENGSGLDYRDPSYSVATRGESVPVEAEERFVVYRPDSGYRTVEPDIRPESRPTPRQSADATAGSRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1V9</accession>
    <name>A0A010Z1V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850716.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2488"/>
    <dbReference type="HOGENOM" id="CLU_037990_7_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="28355" checksum="0D5D9B8B28C03C35" modified="2014-06-11" version="1">MTLTDAADRAGWYDRLFAAIYEPFLALGERRGMAARRRDLLAGAVGSVLEIGAGTGLNLPHYPAAVTGLTVSEPNAAMRAVLRRRLSADAVSRRGGGTSAVSRRGGGTSAVSRRGDGTGAVSRRRDGTGAVLHRQVGVDAIQISPAAAEALPFPDGTFDTVVSTLVLCTVEDPVAAVAEVRRVLRPGGRFLVLEHVRGEHGSRLERRQHRFAGPWEKFAAGCRCDRATAEILGDAGFDGTALRRERWAGMPSIVAPLVVGSLPVAGRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2B5</accession>
    <name>A0A010Z2B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850929.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2646"/>
    <dbReference type="HOGENOM" id="CLU_133313_0_0_11"/>
    <dbReference type="OrthoDB" id="1717097at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="167" mass="18350" checksum="3CADA9C77645EE14" modified="2014-06-11" version="1">MNVNELLIETYGRLPELVRAAGEGLTAEQLSWAPGPGANSIGWLIWHLTRVQDHHVSELRDDDQEYVTGNWGARFGVKSDPSDTGYGHTPAEVAGVRPESDRALIEYYDAVHARTLEYLGGLSGADLDRVVDERWDPPVTLGVRLVSVYDDDAQHAGQAAYVRGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2F4</accession>
    <name>A0A010Z2F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850999.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2688"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29694" checksum="2B8420668B05D1F7" modified="2014-06-11" version="1">MTRKFGLTHLLLTIGALAMVAPFIWQFLTSLKTLEHATSVPPTLVPDGQWSNYTKVFDLVPFGSQFLNTVVMVAARALGQVLMCSLAAYAFARLRFPGRTVLFGLFLSVLMVPPQLFIIPQYEIIADLGWLNSLPALIVPGLFSAFGTFLLRQFFLGLPAELDEAARLDGANPLRIWWSVMVPLARPGMIALGILTTIWSWNDFFWPLVVNNDPEKMTLSAGLASMQGQFLTDYPLLMAGSLLASLPVIAVFVVMQRQFVEGIALTGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4A3</accession>
    <name>A0A010Z4A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3330"/>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458071" evidence="2">
        <location>
            <begin position="27"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="410"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="55443" checksum="FBD2B8F0AD1D3268" modified="2014-06-11" version="1">MKNLAILVAALLLAAGAPASATAAPAAPTPPVPKISWKSCGSAPALADFQCAQVEVPTDYDDPRAGTTTLAVTRLPATDKAKRIGSLFTNPGGPGVPGVSFVQIVGKLAWTPAVRARFDIIGFDPRGVGASDPVTCFTTSQKELAFFADDPVFPMTGKEVQQKFATAKKLAAACRDRSGDRYAHGSTANVARDLDLLRRAVGDEKLTYHGYSYGTFLGATYAKLFPGDVRALVLDGAVDPAAYTGSNGDRRPLAVRLGSHLGGDETIDQFYKKCREAACALAEVGDPEQVTERVLAGLTKRPIRNVLPNGTTFEVSYDDAVQLIHSALSSSASWPQLATLLTVYAKVQAEGKTSVTLTVAQAPSELLAMSPRPEEYTSGAPSFGVCSETAPAGGLRKLPRLAEEAEAEAPHFGRNRAWNSTMCETWTVRDRDAFTGPWDQAVKAPVLVVGTRWDPATPYRYTRTAADYFPDGRVLTVDAWGHTSLAKSACADTAIERYLVSAEATDGTVCAANGGPFDPRPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4M1</accession>
    <name>A0A010Z4M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3420"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="45"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="51567" checksum="CD146AF12D1EF82B" modified="2014-06-11" version="1">MSPNRANQLGGSSVLSALLSPEESSEPTRAPMLLAGSWLIDGPTADRTGPYTRTVVSRARVAQAGDAEAAGRYARAAARTVAALAPATRADVLDRAASAAATHRDAVARLIALELGKPLKDGRGEMDRVVDTFRVCAAEARQIGGDVLPVAGFGRGVGTTALTYRAPAGVALAITPFNAPANLLAHKLGASLAAGNTTIVKAPPQAPATSAAIVALLLEAGAPPEAVQLLHGGGGIGAELCALPEVSVVSFTGGAATGAAVARAAGAKRLVLELGGNAATIVCADADVAHAAAVCAKTGYTNSGQSCISVQRVYVHRSRYDEFLDEFTKGVAALKVGDPLDPATDVGSMVDEDAAERVVRWSRDAGGTVLAGGTRDGATAAPTIVADPSRTANVVTEEVFGALVAVLPFDDFDAVVEECNRSRYGLQAGLFTRDVGTIFTAWRELEVGGLIVNGSSNYRLDHVPFGGVKDSGFGRETPRSMVEDYTVVKTLMLRGVSLWGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKH8</accession>
    <name>A0A010ZKH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847630.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.170"/>
    <dbReference type="HOGENOM" id="CLU_660076_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="44038" checksum="CF3CC31FD534945C" modified="2014-06-11" version="1">MSDRMEDLMRRTLQARAEDAGHSSFEVDDLVQRGESARRRRQLGAVGATAVAAVAVILAGALLGRSASDHARPLPPAASQSTAAASPSTAAQSTAAQSTAAASQSTAAGHGAPVDLTAVKGRHLRTMTRDITVPLNLTATSAEVTEVKGGWVSLPRARASRTGTLSFIDPSGTVKTLATDVDAYVVDTTGTRIALTGGDGVTVGTIRDGRLVSRDTARSRYGARPVTFAGNHLVMKVDGSCCGGDDQEYVAPRFAVWDYVNDAFTPRWTTTVVEVHGPVLGGTRLLGIVRQGSVDDRTGCLALLRPEDLSVESRRCDLGLAWGSGYGTLSPSGRYFFDLDAESDGGALFTIAADLDDVRRTDTEIPNQTPIWDDDTAVASVDGGRSLALWRFGEAPRPIPLFSDLQRLAKRPFVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLA3</accession>
    <name>A0A010ZLA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569625.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.464"/>
    <dbReference type="HOGENOM" id="CLU_026444_0_3_11"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="300"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="439" mass="47019" checksum="2F0AC085DCFD7940" modified="2014-06-11" version="1">MELPRSFEGADALPVDAVPAAVRAAALASRNSGEPVGGYLYDLAAANERAERLVRALPPRAEVFYAVKANAFPPLLNTLAEALHGFEVASVSEARLAIAAARRAGKTPRLVVSGPAKNPTLLAGLLEAPDTQDDTEITINVESILELHRLSRAAVRHAPTTEIPVALRVNPAHSPLKIEHTHGLTMGGVPSPFGIPEPEIPAALRALESLPGVRFQGFHLHAVSGNMDAERHAEYVRGAVDWAVRTADAHGLELRTIDVGGGLGIPFEPGPEFDVAAFGAALDVPDETELILEPGRWMAGPIGWYATEVVDVKHAYGEVFVVVRGGINHFQLPTSWEIRHNFAVVPIDDWPLGLPRPSAERARVTVSGELCTPEDVLARDVTVGRVRAGDLLIFPNAGAYGFEFAMPAFLGQPPAWRAALTRPAIPRPASRVDDLSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLH1</accession>
    <name>A0A010ZLH1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="3" type="ORF">CryarDRAFT_0560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569643.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.547"/>
    <dbReference type="HOGENOM" id="CLU_031248_3_0_11"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="200" mass="19890" checksum="CB76C057B4F6EED5" modified="2014-06-11" version="1">MRVLVVTAVRAELDAAGVTGLVGGVGPVAAAVSTAMALAANEYDLVVSAGLAGGFSGRAPIGSVVVASTVRWADLGAATDEGFLDLSGLGLAGGDALASTGGRWVTDTLGAAGVPALTGEILTLSTMTGTDRRGDELAAVHPSAVAEAMEGYGVAWAARAAGVRWAEVRAVSNVIGRRDRSAWDIPAAFEALRTAVTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLK3</accession>
    <name>A0A010ZLK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569654.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.577"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="OrthoDB" id="1322538at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003867">
        <property type="term" value="F:4-aminobutyrate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="464" mass="47804" checksum="47492E9FA946AC76" modified="2014-06-11" version="1">MTQTGVPQERKLVTAIPGPRSEELLARRNAAVASGVSVGLPVFVTAAGGGIVVDVDGNQLIDLGSGIAVVNVGNANPAVAAAVAAQAAAFTHTCFMVTPYEGYVAVCEALNRLTPGDFEKRSALFNSGAEAVENAVKIARAYTKRQAVVVFDHGYHGRTNLTMALTAKNMPYKHSFGPFAPEVYRLPMSYPYRDSDAGLDASGPAAAARALSVLDKQVGAENVAALIIEPIQGEGGFIEPAPGFLAAVAEYCTANGIVFVADEIQTGFGRTGDLFASEHEGIVPDLVTTAKGIAGGMPLAAVTGRAEIMDAAHAGGLGGTYGGNPVACAAALAAIEEIESRDLAGRARRIGEIMLPALGELAERHSFVGNVRGRGAMLAVELVEPGTTTPAAQLAGAVNKACHQRGLVTLSCGTYGNVLRFLPPLVIGEDLLTEALELIADAFDEVAKSLPAAEAAPHPRPDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLY7</accession>
    <name>A0A010ZLY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.703"/>
    <dbReference type="HOGENOM" id="CLU_032121_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="469" mass="51738" checksum="B0CB19A0E71376BD" modified="2014-06-11" version="1">MGGLTVVSPVGYELGRNARSRVSRSAQAELADDGRNPLTLLAAADEQRLPELLPLRYERMVASPFSFFRGAATVMAHDLALHPHSGLFVQAGGNAHLQNFGMSGTPDRRLVFDLNDFDETLEAPFEWDLKRLVSSVILAARANRFKNGEATTAAASAAAGYRDAMNDYATQRALEVWYDRIEVDDLAQLLKRGRSSVPTLQAVEKARSRDHISAAAKLTERVNGGWRLREDPPLLTHVTDSSDEGMDEELVRRCIREYRQTLPADRRVLLDRYTFVDFARKVVGVGSVGSRCWVVLLAASPNDPLLLQVKEAGQSVLEWHLTPSPYRNAGQRVVEGQRLIQAAPDVLLGWFRDPAAGHDYYVRQLWDAKGSFDTSTFDAPGLAKYARLCGRVLARAHARSGDPAAIAGYIGQNDRFDRSVVKFGQQYADRTETDYAVLVEAVKSGAMPAPRVPAPPRAEPRPFNGSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMA4</accession>
    <name>A0A010ZMA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860511.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.802"/>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_11"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="25332" checksum="539B5AE398CCFB22" modified="2014-06-11" version="1">MTVHFIGAGPGAADLMTLRGKALIESSPVCLYAGSLVPAELLAWCPAGARLVDTAALNLDEIVAELVAADAAGLDVARLHSGDPSVFSAMAEQMRRLDALGLDYDVTPGVPAFAAAAASLKHELTVPGVGQTVILTRTSARATPMPPGEDLATLGASRATLVLHLAVQRISEVVAELVPNYGASCPVAVVARASRADEVVLRGTLGDIADAVAGAGIVRTAVIVVGSVLTASEFSDSHLYSAIRCRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN91</accession>
    <name>A0A010ZN91_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493850_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="18450" checksum="831825C6E914382A" modified="2014-06-11" version="1">MRAASAAMRSKAPSGGRIEDVVPADRPESLDFVGRNQVGVGHCALLEGYPLTRAEGVEMNLSVVVSSAGESGNVGVLRLSGELDIATSGTLRQSLDALRDEGRENLVLDLSGVTFCDSTGLGTVATHARWVMGVGGSLVVCGLRPDVEAVFAISGLSTVLPTATSLERAIELAAAAASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNF8</accession>
    <name>A0A010ZNF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849022.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1265"/>
    <dbReference type="HOGENOM" id="CLU_024648_5_0_11"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="40924" checksum="9F472E5E9FB30BBB" modified="2014-06-11" version="1">MTASAEYDVAVIGAGPAGASAARVAAEAGARVLMLERGALPRYKTCGGGLIGLSRAALPAGFTPPVRDRIDRLTFTLRGRLRRTWRADAPFIDLVYRDEFDAALTAAAVDAGAKLQEGVTVTGLEPAPGLVRIRTAEGEVTAGAVVGADGTSGRSGGYVGVRLAQVDLGLETEFAWPDASAGDWAGRVLIDWGPLPGSYGWVFPKGDALTVGVIAERGQGAATKEYLAALVDRAGVGGAPEIRSSGHLTRCRTDDSPLYRDRVLVAGDAAGLLEPWTREGISYALRSGRLAGAAAVAVARSDADALPLATAGYAAAVEAEFGAEMRAGRRFHTAFSRRPTLFHAAIGCAPPAWRLFRRLVGGETTLEHVAAHKSVDLALRVLSADRSLRSGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPR0</accession>
    <name>A0A010ZPR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783646_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="14318" checksum="A9EF4D1D1470E70E" modified="2014-06-11" version="1">MLKVSIFTDARLRIPKAAELVAASAVAIAHEVAGWLLIVFAILIVAVAGPKRGSRVFAVLFATVIVLVVLSGCAPADSSGADVAPWLVTGAAGAVAGAAAVAAVVVVTAARVAATALGALAGVVRVLMWTALVLAVLVSALIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQI3</accession>
    <name>A0A010ZQI3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="106"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="389" mass="40507" checksum="79FC05344BB47463" modified="2014-06-11" version="1">MHPSDLGWSPGSDADLPPGRGGRHRRVSDLPYRITAALGAALVLAAGGITAYGATHRPADTTVTASRPLAATSEPRAPLPVPETPFEPYVDMGYYPPYDLAGSVEKAGISRYILGFVVAKDGCTPSWDGDVAIDDAEMIQRVEDFRAAGGDIRISFGGAAGDELAAVCASVPALADAYQRVIDLYSATAVDFDVEGNELGDTPGHDRRGQAIAVLQKNAAAAGKNLDVSLTLPVNPSGFTASPIRILTAAAKANARIDAVNVMAMDYGRWAAPEPEGMMGTYATQAMTNAVGTLQEVFGLSEAEAWKRIAVTPLIGVNSPATEVFSLEDAAKVGAFAREKGAAFFSMWAITRDRPCPTGVEADAESDACAGNAPDPFAFTKAFLAAPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQT4</accession>
    <name>A0A010ZQT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="5">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848313.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.600"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_11"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Fe-ADH" evidence="9">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="429" mass="44647" checksum="A5E2F9FDF830FF37" modified="2014-06-11" version="1">MTDLLTESVFTWGAPPLKFGPGAVDEIGYDVARLGVRRVLVLTDPRIAATGLPARVAESLKAAGVDHALYDQVHCEPTDESLRAAAATANDLAGEDGFDGYVAVGGGSVIDTAKAVNLLSTSGGDVMDYVNKPVGAGRAPSKPTRPLVAVPTTAGTGSESTPVCVLDILGLKVKSGISHPSLRPVLAVVDPLVTLSLPAAVTAAAGMDIVCHALESYTARPYTSFLRHTAETRVAYNGSNPVSDVWAEKALTLIARSFRRAVLVGTDLTARSDMMAAATFAGMGFGNAGVHIPHACAYPIAGMVRDYRPAGYDADEAMVPHGQSVSLTAPAAFRFTFPTDPERHVRAASLLSGDPEPDGPPAERLPGALVALMRDIGIPSGVAAVGFADNDVEALVEGTLKQQRLLNVSPRTPTADDLGGIFRSSMENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQV7</accession>
    <name>A0A010ZQV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pilus retraction protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2120"/>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="40885" checksum="7D2E495419497AE7" modified="2014-06-11" version="1">MSEPGGNLWQSWALDGTGAARKTLDAMLRSLVEHRGSDLHLTAGAPPTGRINGSLRPLPDYEPLSPVETTGLARAATDESQWARFEREHELDLAYSVEGSSRFRVNLYLQRGSCAAAFRAIPHEIKPLEELGVPDSVARFAQLPRGLVLVTGPTGSGKTTTLAALVDLANRTRSSHIVTIEDPIEFLHMHRRSLVNQREVGGDTNSFSIALKHALRQDPDIILVGELRDLETASTALTAAETGHLVLATLHTQSAIQTVDRLIDIFPPHQQPQIRTQLSSALQGVISQALAPRADGQGRTIITEIMTLTPAIRNLIREGKNHQIATFLQAGSADGMLSFDQHLAERTRHQVITFEQGLNLCHSAEEYSRLAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQY0</accession>
    <name>A0A010ZQY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol maleylpyruvate isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848376.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233348_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="24021" checksum="3309C251393EF908" modified="2014-06-11" version="1">MSDVRAELEEALPRANSRLVDLVRRIDPDHADRTVPATPEWSVAELAAHVLTVYRRALGDRRRSSSPEETAALNATVLAETPERDLTRLADLLDRDGTAGFAVLRGFPSDLSFRFHGGTRTTVTPVSSVILGEILIHGRDLAEATGAEWVIPPDEAALVLTGSNLPGPDGGPPIFSPWLKPGGERVLAATASTDDPVGALTTFFRRTAPTTPELVAVSRALRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR58</accession>
    <name>A0A010ZR58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of uncharacterized ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569701.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.722"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="292"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="535" mass="56937" checksum="91670654E0B99D66" modified="2014-06-11" version="1">MNDGQTNDAPRTLEAPALELRGVTKCFGPVVACDAVDLAVHSGEIHGLLGENGAGKSTLMKVLLGLVQRDEGTVLRHGEQVEIPTPQAAVTLGMGMVHQHFSLIEPLTVWENVSLGEPGRIKRDEVCDQIKDVGTRYGLPISPIARVEDLSAGERQRVEIIKCLRRDPEVLILDEPTSVLTMAESQELFEVLRDVVNRENRAVILISHKLAEIMAATDQVTVLRKGSVAFRCRTSTTNPRELAKQMVGREVSLGTEGAALGLISEDTTPEEIQAAADVTPEVAPVEAKTPALALSDVVVKGLDGRTLLDNFALTVSPGEILALYGVEGNGQATLGDVMSGLLEPTSGTVAVNGATVPMNKVGALHKAGVGVVPEDRHRSGVVLDMSVLDNLVMTDLGRVSGRFLLKRREARKIAARLIEQFNISTPSMDTPLRNLSGGNQQRVVLARELSTDPSVLVAAQPTHGLDVGAIEDMYERLRAAAGRGVAVLLITTELEEVMALASRVAVISSGRTVGVLDIHEATAERLGMLVGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRK0</accession>
    <name>A0A010ZRK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848616.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.867"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_11"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="29944" checksum="BC68959A8FB42C5F" modified="2014-06-11" version="1">MSVWFITGSSRGFGRSLVRAALDAGHQVVATARRPETLSEFGDQVLPVALDVTDPQAVHAALAAGVERFGRIDVVVNNAGYANVAPIETGDEADFRAQFETNFWGVYHVSRAAIPQLRAQGGGTIVQFSSIGGRVGGSPGIASYQAAKFAVDGFSRVLAAETAPFGVRVMVVEPSGFATDWAGASMTIHDIPAEYDATIGVMQRRVRANDAGAAGDPDRAAEIIVRAASRENPPSHLPLGVNAVEMARAYSERQLDEGAAWAAVGRSADFTEPYPAPHPDEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRR0</accession>
    <name>A0A010ZRR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2393"/>
    <dbReference type="HOGENOM" id="CLU_098240_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="15781" checksum="DD59D05BFA3CE6C1" modified="2014-06-11" version="1">MKRGVRIGVDVGSVRVGVAASDPSGILASPVETVRRDQRSGTDLDRIVALVAEYEAIEVVVGLPRSLSGAEGAAAVAAREYAALLAERLGDSPHPVPIELSDERLTTVIAGRTLSQRGVRGKKHRAVVDQAAAVLILQAWLDAERSADQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRR8</accession>
    <name>A0A010ZRR8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">CryarDRAFT_2440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850612.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2403"/>
    <dbReference type="HOGENOM" id="CLU_087843_2_3_11"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="16245" checksum="7719EF501FABA4ED" modified="2014-06-11" version="1">MTSPTSKDPEKRSARRKARKRALDILFEADVRGTEPLATARDRLAQSDPPVPQYAVTLVEGVTTNRARLDELIATYAEGWTIDRMPAVDRNLLRLGIYELLFREDIPDAVAIDEAVDLARELSTDESPRFVNGLLGRLQLVKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS06</accession>
    <name>A0A010ZS06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850780.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2519"/>
    <dbReference type="HOGENOM" id="CLU_139818_0_0_11"/>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="115" mass="12219" checksum="1D5E76C579BFC074" modified="2014-06-11" version="1">MARKVQVLLVDDVDGSTADETVSFGLDGANYEIDLSTTNATAFRESLAKYVESARKAGRGGTGKTGRAAGPAKPSPSADRAQNQAIRDWAKRNGLQVSERGRIPAEIIEKYHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS78</accession>
    <name>A0A010ZS78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570761_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="500" mass="52063" checksum="A44F07B4078A6730" modified="2014-06-11" version="1">MSTSPQDPSPLPEALLPAADARRGALLREFDRAPGRTAGRRRRVLVPALAAGALAATVALTGVVTQVVDRNDTAPTTGSPAVRPAAPVLRDPDLDAVLARADEVGRRYRNPGFGPADYIYTQSRVRTPSGALVTQEEWFPVDGDGPVVTTRGGTTTESPSGARKPSGPVFTLPVIAADPTYYRLGGGVGIAENGPLALIAEIRKATAKQGDDSDAAVFARLRRMLRVGGHMDGQVRTWLYHAAALVPGVRYDRDEADVAGRRGVALTLTADGKRQRIVLDPTTGALLSQAGSDDEAAPAILRSGLTHEVGGPLVVYRPEPRRSVPDVSLPKESWDPAASVRDLDFANLEYELPLNVDDPEKVIAGVDSGSGGPVGKFRDGVALVPPGGKNPLRLTLDPAIVYVRPTAAQVGPDATGGDAAETAVVVLRMTRAGAPTQYAIIAFSGQPGPLFPGPQSIVLIVTGGPGPVVSASGDTLSVAERPGAPVRRSVRNGVGFEPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSL7</accession>
    <name>A0A010ZSL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851110.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2771"/>
    <dbReference type="HOGENOM" id="CLU_050509_0_0_11"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="145"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="356" mass="37429" checksum="8ED0D3F4549E7C4C" modified="2014-06-11" version="1">MTLRVVQWSTGNVGKHTIAGVDARPDLELAGVWVSNPAKVGRDAGELAGLGRTLGVEATDDADALLALNPDCVVYTAMADDRLPDAIADLTRFLRAGVNVVSSGPVFLQYPDGVVPAGLTDPIRAAAAEGGASLWVNGIDPGFANDWMALTLTSLSERIDEVRCLEILDYSTYDNPTVLFDIMGFGKPIDDVPMLLQPGVLGIAWGSVVRQLAAGLDVELDAVEESFSRLPAPEAFDIPSGSIGEGTAAALRFEVRGMRGGRAVCVLEHITRLRPDLGPDWPQPTGQGGYRVVVTGEPNYTLDMTMLATDGDHNTAGLKATAMRLVNSVPAVVAAPPGLLTALDLPLVTGRGLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT71</accession>
    <name>A0A010ZT71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">CryarDRAFT_1485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1458"/>
    <dbReference type="HOGENOM" id="CLU_069765_1_1_11"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="20792" checksum="123C96716A962392" modified="2014-06-11" version="1">MGGTFDPIHHGHLVAASEVANIFALDEVVFVPTGNPWQKDDAKVSPAEDRYLMTVIATASNPRFSVSRVDVDRPGPTYTIDTLRDLRRLRGPDVELFFITGADALSAILSWKDVDELFGLAHFIGVTRPGYTLSDDHLPQDAVTLVDVPAMAISSSGCRDRVRAGLPVWYLVPDGVVQYIEKRRLYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTF7</accession>
    <name>A0A010ZTF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3076"/>
    <dbReference type="HOGENOM" id="CLU_1238052_0_0_11"/>
    <dbReference type="OrthoDB" id="2043824at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25279" checksum="30252ED39E035898" modified="2014-06-11" version="1">MPALRVLPKETPMSLSLVCLPDDTPAERIAAAAEASLAALSLTTHGPADHFLAGRRRHWFSRIEHESIAGGRLHHLDLAAMRNAAYQLNWYRWTVWQQVVANTRPAQPYWTFLAHHRTTPTRYPLDRAQQDYLAQPRVLVMNTYNALPHRAMDLPTSHLEALQLGSHAYAHFGWLSAVPGDRLLCLDGTLLTAGTGQLAPRMDYLAEANGQIDTLAPDDIVVALRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTL3</accession>
    <name>A0A010ZTL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg-chelatase subunit ChlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849497.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1612"/>
    <dbReference type="HOGENOM" id="CLU_024570_2_1_11"/>
    <dbReference type="OrthoDB" id="736429at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="87"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="33310" checksum="554896F78BDD008C" modified="2014-06-11" version="1">MTWLSPERLWLLAGVAALAIGYLIAQRRRSRYAVRFTNLKLLDRVAPQRPAWRRHVPAGLFLVMIALLVVGFARPQAEVQVPREQATVVVAVDVSRSMLASDVEPDRLSAAKDAAHEFVENLPGQFRVGLVAFAGSAAVVVPPGTDRAALDAGIERLTEGVAGAGGTAIGDAISASLDQIRSSAPGEERPPARVVVLSDGANTAGQNPDEAARAAATEGVPVDTISFGTANGTIAAFNAAAQPVPVDGETLRAVADAASGRYFEAADAEELRAAYADIGSLVGYETEVQDISARFIGVGLLFAVLAALTSLFWFARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTT0</accession>
    <name>A0A010ZTT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851693.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823415_0_0_11"/>
    <dbReference type="OrthoDB" id="826678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025566">
        <property type="entry name" value="DUF4331"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14224">
        <property type="entry name" value="DUF4331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="37238" checksum="E592213ABC4870FA" modified="2014-06-11" version="1">MSHHLDSPLARQDPRLNITDQYVFDDRDGTVFVLNTRTSLAGDTTPHGFHEEGRYEVRIQLDQADVEDLTFRFAFDEEDEDAQRYRLWRLEGDAAGDDTAIGAEIVYGRTGQVIDSPDGIRVWTGRALDPFFLDLDQLAAVDRLFLHGEDAELTGYLPGKAANTFADATVQSIVLRVPHSDRALFAERDIRVWSTTRLATDAGGWRPIGRAGLPMIWPIFRDANSDAASTANETHPSRDAANYGSAIRELVAAAVRRLGTSSRPEAYAARVADRIVPDSLPYRVGTAATFGFAAFNGRHLVDNAPEVMFSLATNSAVSTGLPPELSAGTRSSSFPFVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTZ0</accession>
    <name>A0A010ZTZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851776.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3266"/>
    <dbReference type="HOGENOM" id="CLU_144710_0_0_11"/>
    <dbReference type="OrthoDB" id="1831758at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="109" mass="12041" checksum="59818872AE3F19D7" modified="2014-06-11" version="1">MTYPLVRTPGRAIGRLSLTTFSRTGGVHPDLVRRLVVLGILDPERDAAGDLWFERDQLLTLARVRRLRAGLGINYTALGLVIDLLDRIAALERDLRAPPPRPTGGSSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUM8</accession>
    <name>A0A010ZUM8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920448_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="32681" checksum="CB27BF22A356DA41" modified="2014-06-11" version="1">MRPIERLIVHRSRPGRATVAGRLRHGHGDRSDRAARRSYRADAVHEKPTGSGRSGTAAWARGPGERALPARPSARPVRAATRLAAAMVVRRDLVAALDGGRLNSEPPRPSVGANRSTTTRAVICMNPQVPIPGPDDPIWTAARGFVVRRKEGPLKLLNGGQEQGRVKVTGDRTDGRLGLLELYVAPGFGNIAHAHGDEDEAFYVESGEFRFVNGSTQVDAGPGDFVYIPRGTRHAFKNMTDDTGTLLVFYTPAGPEQFFLDYGDDPDPTGAMPPAWTPERIAAIVAEQDPHKVIPLPGPDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUV8</accession>
    <name>A0A010ZUV8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_3667</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570540.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024186_3_1_11"/>
    <dbReference type="OrthoDB" id="279287at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="329"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG82479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="492" mass="50677" checksum="8B714B59B405A732" modified="2014-06-11" version="1">MDRLRSADVINLAAEAPGVPMHMTVVAVLDGAALCDSAGRLRLDAIRRTVSAGVEAVPRLRQVLHEPGRFAGRPLWVDAASFDVVKHVGRIGVPSSSGEDALLEVAARVLVRPLDRRRPLWRMVFVTGLGDHRIGLIVVVHHVVADGLAATALLLSLLDRPLLPDDGRAPVAPEAPVAPEASGTPVAAGEPVAAGEPVARPGWGALVLDNARGGFGNARHALASVRHVRAAGIRAALRPMVARAPGPRPASLNRPVGPHRGVGVVRFDLAEAARVAHAHGGTVNDLVLGLTSGGLRALLVERGEDVGRLVVTASVAVSLRDRGRDGDVGNRTGAYLVDLPVGVRDPGERLRCVAARTAAVKAAQPSSAATAFLAVLSRVGVARWFSVHQHLVHVVESDLTGPTGPVTVFGAPVLGLIPIGSLAGNVPVSVLALSYAGRLVVAIQTDTDAVPDADTLLDGLRAEWAALRGTNDSRPGAVGAGSLGKRSEGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUX2</accession>
    <name>A0A010ZUX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852327.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3649"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_11"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="34461" checksum="19E9A3CB58D2A8E9" modified="2014-06-11" version="1">MRAAVVPALGAPLEIRDLPVTPPGPGQILVRIEASGLCHTDIHAARGDWPVKPTPPFVPGHEGVGVVTGVGTGVTSVACGDRVALPWLGHACGRCRYCVSGRETLCAGQQNTGYSIDGGYAEYALADAAYAVPVPDGVDPVDAAPLTCAGVTTYKAVKVAGIQPTELVSVVGIGGLGHLAVQYASIVGGTVIGVDVREDKLQLAKELGATYTVNAATTDPVEAIHTLGGADVAIVLAASSAAAEAALASLRPGGRLVLVGLPKDGAIRLPIFDTVLHGKHVIGSIVGTRQDLTEVFALHAAGRTRVITQARALDEVNTAFDEVLAGDVPARLVFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV88</accession>
    <name>A0A010ZV88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850313.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2195"/>
    <dbReference type="HOGENOM" id="CLU_009665_20_1_11"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="488" mass="53076" checksum="D69691CE96E26563" modified="2014-06-11" version="1">MRPDDVDVLVVGGGPVGLTVAGDMARSGRSVTLVERRPRSSFSRPAVATQARTLELLDSRGLADALLETGDPMPAVTLFRDARLELSRLRSRYPFVLITSQTDVDRVLGRYAFEHGATILNRAEVIAAEQDDEGVTATVRPTDGGEARTVRARYLVAADGAHSTIRDVLGVGFPGRSVLSSLVLADVKLTDGPTGTGLVLGSAPDCFGFLVPYGRWDDEGAWFRASTWDRNRQLPDSAPVARDEIASVLIRAMKRDVGLVDVGWRSRFHCDERQVDAYRVGRVFFAGDAAHVCSPMGGQGMNTGIQDAANLSWKLDAVLGGAEDEVLDSYHDERYPVGKSALRRSGVMMRGVTLEPRLARVARDLIASRLLGLRRVSDLLAGNFAGTEIRYARRRGQHPLVGTRATEVPLVGKRLTEVQRRPGFVLIRPRNSGPVAAAEVVRVERTDDGPALLVRPDGYIAWAGTPTDGGWVEELRWWTGVRAAVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVY7</accession>
    <name>A0A010ZVY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850683.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2451"/>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_11"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="33292" checksum="ED32C19BFB4D482B" modified="2014-06-11" version="1">MTRHFLADDDLSPDEQAQVLALAADMKADRHKFTPFQGPKSVAVVFDKPSTRTRVSFAVGIAELGGYPLVLDAGTSQLGRGETIEDTTRVLDRQVEAIVWRTFGQERVEAMASVSAVPVVNALTDQFHPCQILADLLTIKERFGTIKGRTLAYLGDAANNMAHSYLVGGAVAGLHVKIGAPANAQPDPAVVERAKKIAERTQSTITVTDDPVAAATNADVLATDTWVSMGQESASSTERLAALAPYQINAEALKNAKDTAIVLHCLPAYRGNEISADVLDGPRSAVWDQAENRLHAQKALLTWLVEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXJ2</accession>
    <name>A0A010ZXJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851457.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3026"/>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_11"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="424" mass="46495" checksum="CC76FDF314860A5B" modified="2014-06-11" version="1">MDEALSLFESEGPARPLADRLRPTTLGEVVGQAHLLAPDAPLGRMVAEKRLVSMILWGPPGCGKTTIARLLAERSDLVFEPLSATFSGVADLRRVFQAATKRRELGRGTLLFVDEIHRFNRAQQDSFLPYVEDGTVVLVGATTENPSFELNGALLSRCQVFVLKRLNDDALETLVERAGPVPLTSDARQALIALSDGDGRYLLNMIEQLPTSGPPLDVARLAELVQKRAPLYDKKQEGHYNLISALHKSMRGSDPDATLYWLARMLEGGEDPLYVARRLVRFATEDVGMADPQAVAQTLAAWDVYERLGSPEGELAIAQAAVYLATAPKSVSVYRGFDEARAAARRTGSLMPPAHILNAPTGLMRDLGYGEDYQYDPDTPDGFSGANYFPDGMDRETFYRPTTDGNEAGVSERLARWSALREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYX3</accession>
    <name>A0A010ZYX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852194.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3556"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_11"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="261"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="40074" checksum="EDEF6D0623D0D6D3" modified="2014-06-11" version="1">MPEAYIVEAVRTPVGRRGGSLAGMHSADLGGHALAALMRRSGVDPAAVDDVILGCCDTIGSQAGDVARTAWLVAGLPDHVPGVTIDRQCGSSQQAVHFAAQAVMSGTADLVVAGGVQNMSAIPISSAMVVGQQFGFATPFAESPGWRARYGDQEVSQFRSAEMIAEKWGISRQRMEEFALASHTRALAAIDAGHFAREIEPVGDFTTDEGPRRGTSPEKMAGLAPLRAGGRLTAALASQISDAASAMLIASEAAVRTHGLAPRARVHHLGVLADDPVWMLTGPIPATRRALEKTGMKIDDIDLFEVNEAFASVVLAWAQELGADLDKTNVNGGAIALGHPIGATGTRLMTSLLHELERTGGRYGLQVMCEGGGQANVTILERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZJ6</accession>
    <name>A0A010ZZJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3811"/>
    <dbReference type="HOGENOM" id="CLU_069356_43_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="21640" checksum="0EE63BDAB9F5BBAB" modified="2014-06-11" version="1">MPRAGLVPATVVATAADLADEVGLANLTMGLVAERLGVKTPSLYKHVESLDALHRGIALQARREFTQALARATAGRSGADAVHALADGWRRWAHEHPGRYSTSVRAAATDDEEDRRVADEVLRLLYDVLAGFALPGPRAVDAARALRSALHGFITLEAGGGFGLPRDVDRSFSYLVDTLVGGFGAHGDDQHPRGSTPEFHGTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A021</accession>
    <name>A0A011A021_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852781.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1966885_0_0_11"/>
    <dbReference type="OrthoDB" id="2025055at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="13504" checksum="9950C0A76C3933E3" modified="2014-06-11" version="1">MELLTHDPIATGPARGLSLVGVGAMFALAVLDLAAAYCAVRYLRTGHWGWWSAGAAGMVVLFAVYAASLEYAELATVTLGWIVILQVGVVVMDRVANGIVLPPAKWLAIAAILLLMTYLLLAPNRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0A5</accession>
    <name>A0A011A0A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4099"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="483" mass="50264" checksum="0D35CADE28BA1AF6" modified="2014-06-11" version="1">MDAVPAVGAHEVSAWSDEVDVLVVGAGMAGVSAAIDAATAGARVLVVDRGGRLTCTSAMSGGHFYLGGGTAVQQATGWEDTPADMAAYLRAMSPSCDPEKIRLYAADSVEHFGWLESLGFAFERSYYPHKAVVQPGTQGLMFTGNEKCWPFTEIARPAPRGHKPPFEGDMGGGGFVVELALAKLDALGVEVRYDTGATGLVVDGDAVTGATWRRFDEAGAIRARSVVLAAGGFVLNPAMVETYAPRLGALFARGMALGNTYDDGLGIRLGESVGGVADHMEGAFFTAPFYPPEGNVRGVVVNAAGRRFVNEDAYHSRVAAYVFDQPGQAAYLILDAATMERPGYGFQPLVDGWETIPEMEAGLGLPAGSLVETLGAYNAAAPEDPAFHKASEYVVPLDQGPWGAYDLTPGACFYSGFSCGGLRVTPDGQVLRSDGSVVAGAYAAGACASNIAVDGRGYSSGTQLGEASYFGRRAGRHAALARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAR0</accession>
    <name>A0A011AAR0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847558.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042385_1_0_11"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="160"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="44939" checksum="37F47BFE1901DCA5" modified="2014-06-11" version="1">MPIVNSHSQAAAYRPSPLLPSTPVGRQLEWLAEASARVPITDTELRSHTSLSSLPLPPGLHVESFRAQPREAERRAFAVVRDALGDRYHVILRTDAAGRIHSLRCTPVPGSWAELSEQVAALAPRTSLLAAEIDRNGRVRPVHGVEPSVARPIGAAAVLYVIGALAHAVGQGRMRWDEPLAVRDAWKTDLRSPTGRLPDGTMHSLRRYADDAIFSGDASAIDHLVGRLGRGAVEAQHVRFQHAQIGANLPFLTTREATQLKTHPQVSEEYLATDGPRARLEYLRDVVAHLPRPTEWPDEPRFTDSVEWFASPADVTRAFAGLLAQADEQPVLGAVLGQQGTASLALDAGRWPVGWSKGGVEPGVVTENFLARTQDGRTFAVSLMVSDPDRPLDVDATRAVLRACATGAFTLMSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAV4</accession>
    <name>A0A011AAV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569557.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.173"/>
    <dbReference type="HOGENOM" id="CLU_178582_0_0_11"/>
    <dbReference type="OrthoDB" id="1959046at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="90" mass="10185" checksum="CE10C8C125C3ADAF" modified="2014-06-11" version="1">MSAVPGRPLSSDRPEPAHPLRTIREIRTSLPEKQREHFDAELADTDLDALPDVLRRWAVMGNDGFVDFLQSTPFEGLEFGERSYDDANSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAX4</accession>
    <name>A0A011AAX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional DNA primase/polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859937.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.186"/>
    <dbReference type="HOGENOM" id="CLU_057861_2_0_11"/>
    <dbReference type="OrthoDB" id="1173531at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="30908" checksum="BF9DF0E858A27B7F" modified="2014-06-11" version="1">MTRTPTLAAALEYAARGWPVFFLGRTTKRPVANCQPCKAAGHDHNPEACTCLTCHGFYAASADPTRVERMHDRVPCGLLAIRAGRPPGAVAGLVIIDIDPAHGGAVDTALMPPTYCVRTGSGGWHLYYAHPGRPVGSRPMPGRPGIDVKADGGYVVAPPSQHPTTGQPYRRVGDREVRPLPARLLATCQPPEPAHTPSTDRRPDRGGITNPDALLASHLDAVARAPEGKRRTTLYGAARGVARMVLAGALSEADAWSELSRVGRLAGQTERDTRAAIEGGFTAEGVTTGRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABY7</accession>
    <name>A0A011ABY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569652.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_3_11"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26977" checksum="C83EDB86105D2ECE" modified="2014-06-11" version="1">MDWVVELVTDLRAPVLYALVVAVVFAETAVLLGMFLPGETAAIVAGVLAAQRQISLEVVLPLVAVAAIAGDTTGFLLGRRFGPALLNGRLLRRRRAQIDRATATLRRHGALVIVASRFLPFLRTVTPGAAGASGVPALTFLPAALAGGLLWGIGSPLLGYVAADSYHRVEEVIGNTGLVVLALLFVGWWAVRRRRRRQARKAEDPDTERPVDVPAPPVVPVVSTLRRVLAGGYAGTALGVVRPRRRTDRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADE8</accession>
    <name>A0A011ADE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1122"/>
    <dbReference type="HOGENOM" id="CLU_648475_0_0_11"/>
    <dbReference type="OrthoDB" id="1098494at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="423" mass="43639" checksum="E2BE21400D8AE2AC" modified="2014-06-11" version="1">MSAVAATLRELATLGATGALHVEAFSGAVLYLQDGAVTHVDAGSAPGIGTLLTASGRLSKDVWESVLTVGGPTGRVGALLVEQGYLSQGELELCVNGALFDAAYFALTLEPTSVKFVEGERSWFGGALRVDVERLVREVTRRQDQLTRVFPSSEFDSAALTLVARLPKEQIVVDGLRWELLLSADGRRTPLELARMLGRGGFATLLEVRRLAAIGLALSPSATGAAARPAVTPYRPAVGSSAVKAKPASTSSTLSELFGPGDRRGAAEPVPPARAGASAPSVGDAEGAPSSAPLPRRVNGAGTNGTGVTGTGTNGRPANGGSANGAATAKAPLPPLPRRGDPIEAEPVAGERIQPLPPLPKRVPTRVVRPSQQGRAPQEPGDPAPALVASPGPRWPSPPPEIYAEAPSLSSLRRFRDALQEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEF6</accession>
    <name>A0A011AEF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741276_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="373" mass="39615" checksum="41F6DA7196E17677" modified="2014-06-11" version="1">MLSCETLSSSSAHRAPTARIARLPATPRWVQNARSPRAPTGNISGPPSPHSVPPRMSPQLGVLPAPALLRPRDTPARPQGRRLPRPGTTPRPASPRARHLSARHVLRPGTWRAAHPEARYIRAPRMYRASPGAGHLRARPTALRRLLRIPSPPQAAGPRHISGLRHLPELSDPGTSSGLGTLLGFRHLLGSGTSPCSGTSPCSGTSPCSGTSPCSGTSPSPLHLTQSPAPLGSRASLQAPVPLPPLRELSPPSGSRPLIAPRSCARPRRPVPAPVRASRACAHPNAGRHHPLRPALPELSPHLPTRFVSGGRCGRARETTTSGPWENWGGADSCVGEPVRRAARTAPHHSTSYRKRGTPACPRRRARDPPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEL2</accession>
    <name>A0A011AEL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569892.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1524"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="41722" checksum="70D7673930BDBB49" modified="2014-06-11" version="1">MRAVVSLATGVVTGAVTAVLLLGLVTVGALTAPVLIGLPILGAVLLSGLPVGWVERRRLGVDGDPHREPDRPGLRAWLSCRLHERASWRELAYALLLGGLLWWLDLAVLGYGVAVPLSLMSSPVLQAWFDEVKVLKLVLVTTPGQAWAAAVVGVLALPLAGYLIRLYAAGRARLARAFLAPRRGVTDENVVELVRSRARLVDAFDAERRRIERDLHDGAQQRLVALGMTLGLARLAGPDEMRTLVERAHGDARRALDELQEFLRGIHPRILTDRGLPAAVAELADRSGVPVDVELELPGRLPSSVEVAAYFVVCEALTNVARHSGCSSASVTGGQEGSRLVVEIRDDGVGGASAAPGSGLAGLADRVAAAAGRLALVSPPGGPTVLRVELPCAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEU5</accession>
    <name>A0A011AEU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849496.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1611"/>
    <dbReference type="HOGENOM" id="CLU_054927_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="36477" checksum="D33691606C107E50" modified="2014-06-11" version="1">MTVSLGELTPERRLRRLELMITRRLDGLLQGSHLGLLPGVGSEPAGSREYRAGEDEVRRMDWSVTARTTVPHVRTVDADRELATWVLVDGSASMDFGTAEVEKRELAVAAVAAVGFLTAGAGNRLGARVVGADGVRRFPARGGRTHLLGILRTLLSRPRVSQPAPPRAVPFRRRTVVDPGAVPGPGLAEGIADLGRSVHRRGLVVVVSDFLDGLDEDGLGDAPPTWELPLRRLAARHQVLAVHVTDPREHELPDVGVLTIVDPESGQRREVPTAARDLRERYAAAVGRQQATIAGAINRAGAAQLALRTDRDWVADIVRHVYAQRRLGRAARRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF02</accession>
    <name>A0A011AF02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23731" checksum="1746F4662CFE2A90" modified="2014-06-11" version="1">MTPSEASGPDTSGSPSGPQAPRLALTHSDRTGSDDEAALAARFLAGDERALRAMYERWGGLVYRLGRQALPSPSDAEDLTQATFVAAWRGRATFDPDRGRLAGWLIGIAKRQLVDRLRAMQRDARLAQVVEATEPAVPSHPGPERILDRLVVADQLARLVPEQRRVVQLAFFDDLTHTQIAGLTGLPLGTVKSHLRRGIERLRQSWEEVDNAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF18</accession>
    <name>A0A011AF18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotase-like cyclic amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1686"/>
    <dbReference type="HOGENOM" id="CLU_016107_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="480" mass="50781" checksum="7B6F06965B019190" modified="2014-06-11" version="1">MISRGRVVDPETGLDGIRDVGIDGDRIVAVSAAELTGRRRIDARGLVVSPGFIDLHSHGQAIAECRLQALDGVTTALELEAGAAPVSAAYARAAAEGRPINYGFSASWARIRMHVAGGSPLGEGSTGPLEDLGSSAWRGPAALPTILGLLEKELADGALGIGILLGYAAATDPREYLEIARLAAAAGVPTFTHARPLVEQDPDVAVDGAEEITRVAGETGAHMHYCHINSTSTRHLDRVQALVETVRAEGANVTSEVYPYGTGMSSIGADYFHPDRLHVLGATGTPQDVVYARTGETVASVERLLELRASDPSGLAFIRMFDEVKSADRLARFTALPHAVVASDAVPFVIEDGHPYDPMQWPPPAFARTHPRSAGTYGRTLRIARDTLPLTDVLAKCTVLPARVLENAAPAMRRKGRLQVGCDADVVVFDPELVTDAATYQHSVRPSTGFVHVLVNGEPVVADGQLLRDAFPGRAVRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF94</accession>
    <name>A0A011AF94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1751"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="24283" checksum="654BD6167C6543DF" modified="2014-06-11" version="1">MAEPTGSLSKPESLSRQIYATLREGIIRGQYAQGSRLAEQRLAEELAVSRVPLREAVPLLERDGFVRTLPRRGTVVSTWSVAAADDLFDLRLYLEVGAAVYAARKVAAGADTAPLAAALERTRAEATDGDAYQVAQARAGFHDAIVELTGNALMTTLMRPVSGRMTWLFYLTTEPDSPDPAAGNGQLFRAVTSGNERMAEAVAYARIECDRRESLAALRRIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGA9</accession>
    <name>A0A011AGA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850210.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1737495_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16377" checksum="05839522DB7DF5AF" modified="2014-06-11" version="1">MFGHRKHTIAWADRERGAAVLAWTDGHLDEAERAARTALKLRERVSKEDTPALAADAKTLADVLAARDARAEANALYQRALAVYRRYGLQYDAALCLQGLGRLHADTEPTVSRQRLLQALWIKRALLGGIHPEVAELLEDLAAVSAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGH9</accession>
    <name>A0A011AGH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2186"/>
    <dbReference type="HOGENOM" id="CLU_003827_2_0_11"/>
    <dbReference type="OrthoDB" id="1345710at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459482" evidence="3">
        <location>
            <begin position="31"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="4">
        <location>
            <begin position="282"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="558" mass="58497" checksum="C5FA282CAE219529" modified="2014-06-11" version="1">MTRMRTLGFGALTGVAAAGAALGVAEPVAAAVGRGSSPVVAVGLAFIDLVPRPIKDFGIETFGQNDKVALLAGVFVILAVFAVVCGVVSLRHRLLGAAGVALFGVAGVVAAVTRPGAGPVASLPALVGAAIGVGVLLFLAPRAAAVVSAQPPAGSPKPEIPAEPTPDDERTSGRADAMRTDEGASGAADAMRTKTPNGVTATSRRRFLSLAGSALVVSAGLGVAGRYLSSLRDVAAERLKLALPAAADPAPPLPAGVDLKLPDLTPFVTPEKDFYRVDTALAVPQLSTDEYRLKIHGRVRSPMTLTYQDLLDRELVERVITLSCVSNEVGGTLAGTARWLGVPLKALLDEVQPEGGADQIVTRSVDGWTCGTPTSVVRDGRDALIVVGMNGKPLPIERGYPVRMLVPGLYGYVSATKWLVDIELTSFSDFDPYWVKRGWKAQAPIKTFSRIDTPRPLANSKAGTVTVAGVAWAQHRGVERVEVRVDGGEWNVATLAPVPSADTWRQWRWDWDATKVAPGQHTLAVRATDRTGATQPEQRAKPFPDGATGWHSVVVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH83</accession>
    <name>A0A011AH83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850663.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2440"/>
    <dbReference type="HOGENOM" id="CLU_130960_1_0_11"/>
    <dbReference type="OrthoDB" id="1782537at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="12783" checksum="839D561A1F52A883" modified="2014-06-11" version="1">MSSEHPASDAHSLEPDIRDLAEIPSVEVISRAAVMLMSAAAERLGLASDDPDSSPHRDLDEARRLITALAGLIMSSVEYLGAHAAPLRDGLSSLQRAFRESSVIPDPPGQGPGEKLTGPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHM5</accession>
    <name>A0A011AHM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850875.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176213_1_1_11"/>
    <dbReference type="OrthoDB" id="2016098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="10550" checksum="6FF33E0CBAA4EA66" modified="2014-06-11" version="1">MNNVTLAFEAAWKVLLIGLVLGAGLPTLFAFGIRTMAWGQGGSAEVDTASAPHPAGRVVGILCFALVLLAVVLGITYIVAYGFGKELSFEHVYPTIQNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHP3</accession>
    <name>A0A011AHP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850908.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2621"/>
    <dbReference type="HOGENOM" id="CLU_031468_6_1_11"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="196"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="34552" checksum="AEACCEA01C9AC349" modified="2014-06-11" version="1">MRIAVLGAGAIGAYVGAALHRGGAEVHLIARGPHLAALREHGVRVFSPRGNFTAAASATDDPREVGPVDYVFLGLKAHQYAGCGSLISPLLGPDTAVIAAQNGIPWWYFHGLTGPLRDRRIEAVDPGGTVSEVLPVRRAIGCVVYCSTEIESPGVIRHLEGTRFSIGEPSGEVSDRCRAFSDAMVAGGLKCPVESNLRDDIWVKLMGNVAFNPLSALTRATMIEMCGHPGVRGLIAEMMRETVAIAGATGCHPSISIDRRIAGAARVGHHKTSTLQDLEAGKELELEAIIGAVVEIATLTGVPAPTLRNVYAAVDLLARTVTGPRVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AII1</accession>
    <name>A0A011AII1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2888"/>
    <dbReference type="HOGENOM" id="CLU_044063_4_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="4">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="329" mass="33664" checksum="F92A6D7FAFE50E6E" modified="2014-06-11" version="1">MSLSSLASRGTDHVLVGLIGAGIGPSLSPALHEREAAHLGIDYSYRRLDLDELHRDPDAVGDLVDEARRAGYRGLNITHPCKQLVIPHLDELSRAAGEIGAVNTVVFAPDGRTTGHNTDWSGFRNGMVAGLPGVDRGAVVLLGAGGAGAAAAYALLALGAGTVHVVDVDKARAEALGGRFTPSARAADPAGPSARAASSCPPVADPASDGVGESGAGRVTGHRVAELAELLAVADGLVHATPVGMAEHPGLPLDPGLLRPGLWVAEIVYRPLETELLRAARSAGCRTLDGGAMAVHQAAAAMRLFTGVEPDAGRMTGHLHELIRAETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIP2</accession>
    <name>A0A011AIP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088678_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="27073" checksum="DF5D10C33A4A960A" modified="2014-06-11" version="1">MTLWEQVPTTFVAVHGWDRSRLESDLARYQADGLRPDQLGPYSVDSPSVARFTPIRRRRDAGVVVPALVADFARGHGLPAVSLAVVREDLLRACGVGGMLTARDAPPNGDIIRCYPSPGDEDPYRIRIDRMDAHGGWMATAVDLLRFAVRVDGSGSDVQAPASTAFMTTPSGLAGSSGYGAGWTTSGEGAIDPGVGSHTGVLPGATGLLQRSPDGLTCAVLTNTNVRHEVTDTSTDTVPGLFRLLARIRGQVDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJJ5</accession>
    <name>A0A011AJJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570357.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="96" mass="10375" checksum="59C3B4BD3B694EE9" modified="2014-06-11" version="1">MRTGSGHRLSLLGELDQEGALVLRRRVEHLETSTGGRAVLDCGCLWFIDARGLNALLYARAFLGDSGVSLELVEPTPMLRRVLAATELTDALPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKE9</accession>
    <name>A0A011AKE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852251.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3593"/>
    <dbReference type="HOGENOM" id="CLU_021844_0_0_11"/>
    <dbReference type="OrthoDB" id="688261at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="556" mass="59721" checksum="BE4558FB20FF6093" modified="2014-06-11" version="1">MAPLPPTRRQKVVRRLPRRVRHYWKLLVACVAFVGVLAVVLGTVSVRPYVTSASDEGADAVTQNVAGTKDLFDAGVAHSIQLSFTQAAYDKMLDQYFQDGEKEYVEADLTIDGTRLPSVGIRLKGNSTLGGLTRDGKAATRGPGGFGGENRPGRDAQPPGGGFPQNGQLPEGFTPPDGAQQPGAAQPGQQQPGAAQPGQQPGGGFGRTALKAEEPEKLPWLIRVDEFVEGRRYQGHRDLAVRVSGMGGGTTVLNEAVSLQVLAAAGEVAQKYAYTSFTVNDRPTTARLVVEHPDENFADQMDGTGVLYKSLATGRFTDQGDDQTDYQDDFQQITKKGSQDLQPVIDLIRWVTTSSDKEFDAKLDEHVDVESFARYLAVQNLLLNFDDMSGPGRNYYLWYDLSTKKFSVVGWDYNLTMSGDGTSGPHDSVSMGFGGDRPQGQQQGAQQPPAGMQLPEGVEMPGGNGGPGGLGGGHTLKERFLASAAFDEVYETAYRELYTKIYGSGSALSAVKNIVAVLRTVDGGDSGTLASESSQLEDLITRRTSSLAQDEVITQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALL9</accession>
    <name>A0A011ALL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852780.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3990"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="38986" checksum="94F87A3BB5E42439" modified="2014-06-11" version="1">MRYIKLGTTGLDVSSIAIGAMTYGEPDRGHPVWSKGEEDARPLIRHALEAGINFFDTANMYSNGSSEEILGRALRDFADRDEVVIATKLRHPMRLGPNGRGLSRKAVLTEVDHSLRRLGTDYIDLYQIHRNDRSTPWEETLEALSDLVTAGKVRYLGALSMHAWEFAKALHLQKRHGWARFVSMQDHYNLLAREEEREMIPLCLDEGVGTVVWSPLARGRLARAWDDARATARSATDGSYADLLYPPLEEASDRAIVDAVGRVAGARGIHRAQVALAWLRHQPVVTAPLVGAGSIAQIDDAVASLDVELTDDEVRALEAPYTPRHDWQGISDEAELEAVRRRVPGMALSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALP8</accession>
    <name>A0A011ALP8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="15599" checksum="BBF9B4E86F5846EC" modified="2014-06-11" version="1">MTNEPPYSTTTLDSDDEEAIRGIVRDVEEGFNRNEPELLGVHLAQDAVVGNALGVWSEGRAAIDEANRVGLAGFLRDATAHYEVSGVAALAPDVAVAQKRAWSTHTAADAGEEPEMIALYVFVRRDGRWWIARRQNTLVAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFZ3</accession>
    <name>A0A010YFZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847620.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.166"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="245" mass="26774" checksum="D22B4E3B93E23476" modified="2014-06-11" version="1">MTVAVDLRGVSKRYPGGTVALDGVDLAVEPGEFVCLVGASGCGKSTLLNLVAGLDSATAGSIEVDGGRAAFMFQEPALFPWLKVGQNVEVPLKLRGVGRAERRARAAELLQTVRLGDVVDKRPHELSGGMRQRVALARTLAHDARVLLMDEPFAALDAMTRDALHDELERVWLERNLTVLFVTHNVSEAVRLGDRVILLASRPGRVIEEFEVEAPRPRRLDSPDVAALAGRVTERLKEEVRRHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGB6</accession>
    <name>A0A010YGB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847783.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="S01.513"/>
    <dbReference type="PATRIC" id="fig|927661.3.peg.273"/>
    <dbReference type="HOGENOM" id="CLU_043139_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="41013" checksum="FC320CEF30F2A452" modified="2014-06-11" version="1">MDGSLLDLALLVGIVGFAVSGYRQGFVVGALSFVGFFGGALFGVQLAPVIANQFASQTSKVATALAVAFGCALIGQVLAVAIGSRVRAGMRSSSLRVVDGFGGSIVSVIALLLVAWMVATPLASSSSPWLAGQVRRSVIIPAVNDAVPDTVRSLYDRFGDVVEQGDFPQVLGPLTPTEVRPVAPPDNALARSEVVRASEQSVVKVIGQAPSCDRRLEGTGFVYSDGRVMTNAHVVAGTEDVQVESLGEKFQAKVVFYDPNVDVAVLDVDGLDAPVLNFNQRAASGDDAIVVGYPEDGPYTATAARIRDERTIKGPNIYQSGQVTREVLMLRSQVRSGNSGGPLLSKDGTVYGVVFAAAVDDKETGFALSVDQVSDAAVQGKRATEEVSTQGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGE2</accession>
    <name>A0A010YGE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847864.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.318"/>
    <dbReference type="HOGENOM" id="CLU_119460_0_0_11"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457866" evidence="1">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="15890" checksum="9F527F460E7EEBD6" modified="2014-06-11" version="1">MRTVRLAFSPTPAHVRTARLVAVATARNAGVAEGILDEIRLAVGEACSRAVSLHVQHKRSELVEVEFTDGPRFEVVVRDSAPADQALHADLAVTSPFVAGPAFAETESEEEVAAGVGLALLTGLVDDVTVTPATDRDGTVVRMTWESSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGM3</accession>
    <name>A0A010YGM3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="11" type="ORF">CryarDRAFT_0440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.424"/>
    <dbReference type="HOGENOM" id="CLU_084630_1_0_11"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="10">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="20482" checksum="79123F42AB8E466F" modified="2014-06-11" version="1">MTITPEPPPAVPTVPDLGGVQLGSELPAPVSPAPISPAPAGAPLLVDEPAPRLPRVGIGNDVHAYDEGRECWVAGVQWPGQPGLAGHSDGDVAAHAACDALLSAAGLGDLGSNYGTDRPEWANAAGVALLTETAKRVRAAGFLIGNVAIQLIGGAPRIGTRRAEAEQALAMAIGAPVSISATTTDGLGFTGRGEGLAATAVALVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHA2</accession>
    <name>A0A010YHA2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848428.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.684"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_11"/>
    <dbReference type="OrthoDB" id="287662at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="42135" checksum="7FCBA3211E4C6048" modified="2014-06-11" version="1">MSTEAYVYDAIRTPRGRGKKSGSLHSVKPVSLVTGLIETIRTRNPELDPREIDDLVLGVVSPVGEQGADIAKTAAIASGLPETVSGVQLNRFCASGLEAVNIAAQKVRSGWEDLVFAGGVEAMSRVPMGSDGGAWAQDPETAYATGFVPQGIGADLIATLHGWSRTDVDAYAARSQQRAAKAWANGYFARSVVPVTDLNGSTVLDQDEHVRPDTTVESLSGLPASFAGIGDQGGFDAVALDKYHWVERIEHVHTAGNSSGIVDGAALVVVGSEEAGRRNGLTPRARIVATAVSGADPTIMLTGPAPASRKALAKAGLTVDDIDLVEMNEAFAAVVLRFMADTGFDEEIVNVNGGAIAMGHPLGATGAMLIGTMIDELERREQRYGLVTLCVGGGMGIATVVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI37</accession>
    <name>A0A010YI37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848713.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.981"/>
    <dbReference type="HOGENOM" id="CLU_1895279_0_0_11"/>
    <dbReference type="OrthoDB" id="2009037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="16755" checksum="40CFE08BE6130C93" modified="2014-06-11" version="1">MLPTLWGRIQSRIVFTLVIGGLVALFLTPLLPLQVGIGSKYRIAYTVLVTVTVIGVLWELLYHLIMQWRWEKDWPTLVGLLTFINEGLLIWGLLLAGAVPGIDGLSGLQSLSYWILFLFVWVAVWIFANGPMRVFSIHWRFRGGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIB9</accession>
    <name>A0A010YIB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569779.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1050"/>
    <dbReference type="HOGENOM" id="CLU_462200_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="554" mass="56028" checksum="3AD82B2A2F3801A7" modified="2014-06-11" version="1">MSTPLGSRYELVEKIAGGATGSVWRARVLATGELVAAKQIRAELAGDADVVDRFLRERRVLTSIRHPAVVRIRDLVVEGEQISLVMDLVDGADLRHTLAVAGALAPTSAVLMAATIADALAAAHAAGIVHADVKPANVLVPADGGSIQLADFGVSRLVHGPAKLSYGTPEYIAPEVVGGHASLPASDVYGLGIVLYELLTGTTPYRGGSSAEVMKRHLNSVPLWTDAVPDAVRPVLSACLVRDPSRRPTAETLAADLRAAAPELAGMKAATPLPEGTPHFQVAPVVESVTGGVEPDERVTSVLAQPTVARPQVRPNPTLALPEPDPAPALAPELVGAAAPVSPSGTRPGEAFAMVGPSDSDLSGSPSNGTPGWDSPGPGGQLPPPPAGGYGQPPSGGVAPTNVFPAGPPSDPGAKPPSFDDTLSPPRWAFPAGTIPPRQEPPKKKRWPLIVGLVIVLLVLIGVVGGAIAVLGSSGDEADPKPSTAPSTQPAKPSPSQTPSSAPSAAPTQPGNQLPSTGPSGVPVVPGPDGTNAPSNPMPTTMPSDGGEIGQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIJ6</accession>
    <name>A0A010YIJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848864.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139202_1_1_11"/>
    <dbReference type="OrthoDB" id="1830807at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="133" mass="14527" checksum="401438E856EAE54D" modified="2014-06-11" version="1">MPGIDESLQRAMAISGARGANIVDFTSGLVVGTVGDWPYGGPDAAAAGATEVVRAARDNSAFVGPERPGGAPDDEDRWEDIVLTAQGRYDLLRFLHTQFDGRFFLHLWLDRSQSNLAMARLELRRLADELVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIV4</accession>
    <name>A0A010YIV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1217"/>
    <dbReference type="HOGENOM" id="CLU_063236_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26159" checksum="9CB4C5F647892EF4" modified="2014-06-11" version="1">MTSDVTDGTAVDGARRRMLELITSGSLEPGQRLGSERELASDLGVSRTTLRQALGALEQSGVVRRVPGRGGGTFVSRAKIERDLSSVVGVPALLRAQGFTAGSRVISASILSADEVTAAALNLDAGGLVTEIVRIRLADGSPVSLEHARLPAERFPGLLELPLGGSVYELLDEHYGVRPVEALERIEAVSAGPTEASVLGVDAGAPLLSITRTANDGDGVPFEFSHDLFRADRTRILVRTPGAAGAAAEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ97</accession>
    <name>A0A010YJ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335692_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="23381" checksum="ED13BDCC73ACCB4E" modified="2014-06-11" version="1">MTRNRPPGRLVAARSRSWLLPGIPPPRTINARAPTDDDELLEMGRRRPVLALAATGVVLVLGLVACTVGIGFSVVDDTPNDPEVRVMWFLSWAFPDVGEKGPWRRNVCGDATDRIGAVIDTEDRRLHDQFAPDWIASHAWNPDYRSTENKKRATVTVEGRLEIHRADESGFNPYSVPDRTWTFTLRRNWMREWVWCIDHLETRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJC4</accession>
    <name>A0A010YJC4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="7" type="ORF">CryarDRAFT_1385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1359"/>
    <dbReference type="HOGENOM" id="CLU_022752_1_0_11"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="256"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="681" mass="69359" checksum="19F5C9937B59E9FD" modified="2014-06-11" version="1">MVTVVPRLVIAAPASGHGKTTVATGLLAAYKARGLRVSPHKVGPDYIDPGYHALASGRPGRNLDPYLVGPHLMGPLFAHGAAGADLAVVEGVMGLYDGAVGHGDLGSTAQVAAALRAPVVLVVDSSAQGRSVAALVHGFRTYEPSVWLGGVILNRVGSERHEKILRDACEEIGTPVFGALRRRDAISTPSRHLGLVPVAERSQEATEAVDAMGRIVAESVDLDRLLWLARSAPPVSADPWSPSEAVGGRVSERPVIAVAAGAAFTFGYAETVELLEATGAVVARFDPLHDESLPEGAAGLVVGGGFPEVHAEALSANEPLKKAVRELAASGAPIAAECAGLLWLTKSLDGKPMCGVLDAEAGMTPNLTLGYRSAVAISDSQLLPEGTRVHGHVFHRTQVEPRAGARPAWQWQGRPPEGFVQDGIHASYLHLHWAAHPVIARRLVDAAARLQRRALPAVAAGPSNTLVDAPRALPPASADPAPTKIDTPADPASAAPTAVAPAPTAVEPAVPTPTAIEPPAATPTAVEPTPTPTAIEPAGDETPTAVVPAGGSGEDREAADAAAARARAEADAAAARTRAEQDAVAAGTRDAVKSGTRDAVKNGAGSDDAAHEAAGIGPDRRADGDEGTDEAVAPGVASMKENGTTADGNDIATADKNGDSGSLPRVSRSDGPASAPDRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJJ2</accession>
    <name>A0A010YJJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM-linked protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849262.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1451"/>
    <dbReference type="HOGENOM" id="CLU_083579_0_0_11"/>
    <dbReference type="OrthoDB" id="1514287at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="28668" checksum="B694C050102C85BB" modified="2014-06-11" version="1">MPDGPPPPPVVQRVRLRYTKRARLRFTSHRDFARAFERALRRGGVPIAYSAGFSPHPKVSYVGAAPTGVASEAEYLEIGLAKVVDVEQVRQMLDRALPPGIDILEAVEATGGSLPDRIDASEWRIELPGVSTVRAQSAVAALLAAGTVPVERRTKSGQRTIDVRSALVSVVVVEEVGPAGTTGTASTEAEPGVSTADADVPCAIMICVVRHTTPAVRPDDILTGLRHVVASADLDPAEPPRATRLAQGALTAEGRIDDPLEADRGGLAIGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK78</accession>
    <name>A0A010YK78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1694"/>
    <dbReference type="HOGENOM" id="CLU_006850_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="773"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="840" mass="89351" checksum="81A8CDEF27E34DFC" modified="2014-06-11" version="1">MAGPILERETELSTLGAVGAGSVVLIAGEAGIGKSTLVDALPDVLPAGTRLLVGYCDDLATPRVLGPLRDLIGSVSTALTEALESGDRGRVFDALLAELTRPTVLVVEDVHWADEATLDVLRFLVRRIRRLPSALVLTYRNTDDQALRRLVGAAADAQRLRPARLSSDAVRRLGAHTGLDTAEVFAVTSGNPFFVTEVLASGDAGTVPRSVAEAVRGRLSHLSPVTRRVVEQLAVIPSAAEPWLVEAVVPGGVEALADAEQQGVLTVSPVRVAFGHELARRAVLDSLPAARRIAANRAVLAALLDHRDVDVSRIVHHAAEAGADDPILRFGPVAARVAAAGGAHRAAVAHYRLVLDRLAAYPPDEQADLVEAYAIECQAAGRAKEAVTAQEDAVRRRRARGDRPALGISLRLLSRMHWWAGSRTEADRCGAEAIELLESAGDEHALAVALSNQAQLHMLAGRIRDAIQLSERVAGMARALDDAGLLSHALNTLGTCIWPDGQAHLEESLEVALAAGEAEQACRAYVNLASPLIEDLRLDEALHHLDAGIAFAADAELLGHERYLRGSRIDVRLLRGEWELADHEARSLLDAEEPIVRCHARIVAGLVRVRSGRDGGEELLREAWDHAQELAEPQHVCPAGAALLESAWLRGDLPRAAAEAADVYRRLRGFGRAPGLAELEYWLHAGGVPVTVSGGPFALLSAGAWREATAEWEQAGCRYAAALAAAFTSDPDALLAGLRTADELGASPLAGRLRARLRELGVTRVPRGPQPATRSNPGGLTNRQADVVRLLADGLTNAEIADRLVLSVRTVDTHVAAALDKLGVRTRREAVSRARALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLD1</accession>
    <name>A0A010YLD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570005.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2101"/>
    <dbReference type="HOGENOM" id="CLU_328660_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="577"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="620"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="661"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="789"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="838"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="874" mass="92555" checksum="DD358370079DD6C2" modified="2014-06-11" version="1">MSGWSSDSGGAHPGGGSPGEGGPTLTEPQIVEGRSIRLPVGTGPGVRVLLRERISKNTGQATVFTAELLDPLPEAGEPGDPVAIRVVLERRGRPDVLQRMRREQRYATALRHPFLLPVFAQAEMPEFRREFDGTCLALVQVMPLCGEDLEDQVVKSNPPRLTADQILFDLVGIADALHHLHTPTGQRGVLVHRDVKPANILRWDRRSVLGDLGTLRDPQTGNPTGGVGTIPYMPPDEGTSPTPAWDMFSFGVVLAELLTARRPHDVAEKTPLAYLQAHLRHSLRPDLDDLIEAEVGPERGRVVAGLVRRCTDPEPRNRPTAAAARDELLPLLTLDEQLRLHELVAFDTVEALDVIAISALRLYGDQHPVTRSAAERLAATLVASAAGLMEEGRPGRAKDYLERARRIQGALAEGGPTPVEPSTDAPTRQQHWTRTHSDYPAIAAPVSGSAPVSGAAPVSGSAPVSYPVSSHPVSSHPVSSHPVSGNPVSGHPSAGGTAVYGAPYGYPPPGPPAPPKKKKKRTAPLLAGLAVLVVLAVAGAGIYLLRPTGDDDRDVAAPRVTATPLAVGPSPAVQNKFSGHTQWINAVAFSPDGTRIASGSGDSTIRLWNVEDRSQIGEPLTGHTGTVYRVAFSPNNLLASVGGDGAVRLWNTTAGTKVGALTGHAGDAYGVAFSPDGRTIASSGGDKTVRLWDVASQKQIGRPMTGHTDEVYSVAFSPDGKTLASSGADDTIRLWDVATRTPIGDPLKQTPGDIDSIAFSPDGRYVAGGGSDKVVRIWDVEKRSVHQALRGHTDNIYSLAYSPDGRTLATAGIDDTTRLWDLTTGKQIGAPLKGTGDVDAVTFSPDGRLLADGGDEKVVRLWDLDTRPVPTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLF7</accession>
    <name>A0A010YLF7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2126"/>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_11"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="522" mass="53515" checksum="9118B705D255A0C2" modified="2014-06-11" version="1">MDGMGDAVLVGAVLVGARPLEPDDVVAVARNDAPVALAPSAEQAIEASARVIEALAGDDTPHYGVSTGFGALATRHIPPDRRVALQHGLIRSHAAGSGPEVEREVVRALMLLRLATLATGRTGVRLSTARAYAGMLNAGITPVVHEYGSLGCSGDLAPLAHCALALTGEGRVTDALGNVGDASDALAEAGLTPVALREKEGLALINGTDGMLGQLLLAAADLRRLLRTADLTAAMSVEALLGTDAVFAADLQALRPHPGQAASASNLRSVLASSGIMASHRDPHACTRVQDAYSLRCAPQVHGAARDTLAHASAVASRELASAVDNPVVTVDGRVESNGNFHGAPVGYVLDFLAIAVADVASMSERRTDRMLDVARSHGLPPFLSHDAGVDSGYMIAQYTQAAVVSELKRLAAPASVDSIPSSAMQEDHVSMGWSAARKLRRAIDGLTRVLAIELLTAARALDLRAPLTPAPATAAVVARLRESAPGPGPDRYLAPEIESAVALVTSGAAIAAAETTTGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM43</accession>
    <name>A0A010YM43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2328"/>
    <dbReference type="HOGENOM" id="CLU_072769_1_0_11"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33684" checksum="F199CD2C001A6E5C" modified="2014-06-11" version="1">MIAGMSVSRHSDVPVYRQIVSQLTLMIEMGLLTDGERLPGSRLLASNLGINRNTVAHAYGELRELGLVEPRGRNGMVVVGGKGARTSSEARNRAREILAAAARECLQLGLSAPEIRDLIGGLAAWEAEKVLAVSFVECNRERAEYFAAELAARLAVPVKPLVLGEFDADAERPDLVLTTFFHLAEVRGRLRGPSTEVVAIVAAPHIRTLVQIAEVPKDRTVGVLYSTNDQAVSIRDSLAQAGVTNVVVLSGTGDAELRGVEAVIVPSELPELARALAAKRVRVIEYGNVLDAASVRMAAEVMRELQLARSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM83</accession>
    <name>A0A010YM83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase (Rotamase)-cyclophilin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850593.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2384"/>
    <dbReference type="HOGENOM" id="CLU_012062_8_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="110"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="28430" checksum="5A86CB4D124DDA99" modified="2014-06-11" version="1">MPTKDRQRQLARAKLERQMARRAAAAKRRRQTQAAVGAGLALLLVVVGVGFLIANLGGDDDKKTDTATEASGPQCTYQKADSSTGQVKDVGTPPTTNIPETGTRTVTMTTNIGQVDFSLDQASAPCTSNSFAFLAGKKFYDKTSCHRLTTAGIFVLQCGDPFADGTGGPAYRYGTENLPTNQHPPYPAGTIAMAKSSEAISVGSQFFIVYKDIPDGSLGADYTVVGKVTKGLDLIVKAAEKGVTPADPSNPGDGKPKQAVTINTLTVSPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMT4</accession>
    <name>A0A010YMT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2610"/>
    <dbReference type="HOGENOM" id="CLU_053496_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="43225" checksum="60B14F8853FEA554" modified="2014-06-11" version="1">MAGRDKVGTVEDLHASATKITGLDDFGDDDYREGLAVLLESYAADAALTPLGNAVKRAFLRGALVARLLSEFAWKQHPEYARVPVERPIFVTGLPRTGTTALHRLLTADPAHQGLEMWLTEAPQPRPPREAWDADPLYQRIQGAFAQHHVEHPEFMGLHYMSADQVEECWQLLRQSMESVSFECLAHLPRYSAWLAERDWVSAYARHRHNLQLIGLPDAGKRWVLKNPSHLFALDALFAAYPDALVIQTHRAPRTAMASVCSLAQAATAGWSTRFTGDVVGRDQLDLWSRGLDRFRADRAKYDPAQFCDVEYSEFVADPVGTAERVYGHFGLDLTDAARAAMAALHEESRTGDRKPAHRYTLDDFGLTPGQVDERFTDYLSSHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN56</accession>
    <name>A0A010YN56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851029.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2710"/>
    <dbReference type="HOGENOM" id="CLU_033975_2_0_11"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="42748" checksum="6E4FD044856D41FF" modified="2014-06-11" version="1">MTGPPENGPLHGLRVLDVSTILAGPLACQILGDYGADVIKIEHPRTGDSMRGHGGQKDGVPIWWKEISRNKRTVALNLSDPDGAAALTKLAARADVLVENFRPGTLERWGLGPETLHAVNPGLVLVRLTGFGQTGPYSSRAGFGTLAEAMSGFAALTGAADGPPTLPSFGLADSICGLAASSAALMALRHRDRTGRGQVVDLSILAPIMTAVGPGPTVYQQTGEIEQRHGNRSTNNAPRNTYRTADGSWVAISTSAQSIAERVLRLVGHPEVIEEPWFATGRGRAAHVDELDAYVGDWIGARTRDDVLAAFTGAGAAIAPVYTAKDLVEDVHVRETQMLTEVDDDELGRVLQHNVLWRMSETPGRIRFPGRALGADTDEVLTEAGLSADEIQALRDREVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN96</accession>
    <name>A0A010YN96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851074.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2740"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="313"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="559" mass="57800" checksum="9C7C052856A13D64" modified="2014-06-11" version="1">MAEPGNRVLARAVSRNRRRLAIGTLLVSAHQICETAVPILIGVIVDTAVATGDRGNLAGWIGALAGLFLALTLAYRFGARQLVRSIAEEAHRLRMEVSAKILDPRGITTDLPAGELLTVSTSDADNTAELLDYLPRIAGAVVATVVSAAALLVVSVPLGLLVLVCTPIVLGVLQLVSPRITERVASQQELAGRATSLATDLVSGVRPLRGIGAERAASARYSEVSRRSLAATLRAARTQGAYLAASTTLSTVQACGVAILAGWFALTGRITVGELITVIGLAQFLIEPFGLLALIPSWVASARASAGRVAAVVDAPPLLPAASAPLPAGPCAVELAGLRYGPLELDLLVEPGEVLGVVATQPAEGEALVRLLSGRVAPGEYAGRALLAGHPLHELDSAAARGALLVQPHKSDLFGGTIEANIAAGTTDRDHWDAVLRSSAADEVIGAHPDGLGHVVVERGANLSGGQRQRVALARALLVRSQVLVLHDPTTAMDSVTEHVIAQGIRAQRAGLTTVLVASSPALMAITDRVVMLDGGRIVATGTHTSLGSHDAYRKAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP00</accession>
    <name>A0A010YP00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase (Isoleucine patch superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2985"/>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="19797" checksum="A7A929C33EB74122" modified="2014-06-11" version="1">MRERMLAGDLYRGADPELDAEMRQAMVLTKAFNDSDPRDPAGRRALLEQLLGTIGDEVDLRPPLHVDYGSHLHIGDRTFVNFGLMALDVAPIRIGTDVLIGPNVQLLTPTHPIHPEPRRAKWEAALPITIGDNVWIGGMAVICPGVTIGANSIIGAGAVVTKDVPADVVAVGNPARVIRSVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP33</accession>
    <name>A0A010YP33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851453.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3024"/>
    <dbReference type="HOGENOM" id="CLU_043966_4_0_11"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="20011" checksum="4CE7DB30074FDDA8" modified="2014-06-11" version="1">MRKLVYYVGVSIDGYIAGPDGSFDFFPLGEDLAGWIGANLPETLPTHARAHFGVGNAANKRFDTVVMGLGTYRPALDAGIASPYGHLRQYVVSSTLGGIADPAVELVGRDPVALVRALKAEESPFDVWLAGGGTLAAAVLPEIDELVIKSYPIVVGDGISAFTGAFGPTAFTPAHRETFASGSTVTHYART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP98</accession>
    <name>A0A010YP98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3107"/>
    <dbReference type="HOGENOM" id="CLU_2301121_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="9971" checksum="93B64131244FEB60" modified="2014-06-11" version="1">MSARRVALLGTGVAVVVVAVPFVFLGSARAVVIGALVSATAGVAAVGVAVWAALRQPTVDDAIAIQPEPGAVSNEISGTVHGGVVQARDIDGDIRFNRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPV2</accession>
    <name>A0A010YPV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3326"/>
    <dbReference type="HOGENOM" id="CLU_132888_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="118" mass="13113" checksum="4E4D8E3B034A1A38" modified="2014-06-11" version="1">MPAEPKGILVSDNVHVHDNPAQHRYEVTVNDDLAGFAVYYLDGQRIVFIHTEVAVAYEGRGLGSRLAQRALDDVRGRGLRVVPACPFFAKYIRNHPEYQDLTRSGGQADRVVLGEHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ44</accession>
    <name>A0A010YQ44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-dependent enzyme, putative carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851984.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3422"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_11"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="196"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="397"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="574" mass="61093" checksum="CD6B3AF434E7CDA6" modified="2014-06-11" version="1">MTTTAAAALTAQLESYGVEYVFGTCGHTNIALLDALGRSSIEFVIARHEQAAAHAADGYARASGKPGVVLLHVGPGMMNAVTGVATAALDSVPLIAIAGDIPSYYHGRHPHQEVNLHNDADQTAIYRPFVKRAWHVQRVEDLPRFTERAFTTAVSGRPGAVLLDVPMDLFSRPQTAESYPMPGELTRPDLPEGTAERIADALVAAERPLIYVGGGLSAGPGREALTALVEHLDIPVAHSLMAKGSLPDDHPLVMGMPGFWGLEETNRYAREADVVLAIATRFAETDASSWNDRYTWSFPPTRLIQIDIDPAELGRNFPVEIGAVADAALAMRRIAAAALRRPEASRPALRESITAARGALFAGSAERGRSDDFPLRPERILLDLRETLPADTVLVTDVGWNKNGVAQAYPLPVEGRFITPGGASTMGFGPAAALGVQIAWPDRPVVALIGDGGMSAQLPALPMAVERGLPVLFVVMNNQAHGTIADLQAANFGAGYGCEFTDADGNPYSPDFAALGQACGADGYRIEEPGDLRKALHAALANRRPAVLDVPMVNEPVPTPGHWNIKDIYAGIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ72</accession>
    <name>A0A010YQ72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570452.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154924_0_0_11"/>
    <dbReference type="OrthoDB" id="2028006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="26173" checksum="F97F0C2BEC18DA0D" modified="2014-06-11" version="1">MGHPVTVHHERRLYPVTHGEELIFGRGRNCQIRLAHEPEDTRVSRTAGSFSLLPDSVLIRNLSTSRELYLVAAQTPDRVLEPHSATTSLPHLTFDLVVVGNHGRTYPLRVDASRLTATPAVRRPSRAQAGEKLTAPGADDLNLTPARRRLLAALCRPLLDGKDDPATYREIAVRLGLNAGHVRNSLREVREMLAGAGVPGMVVAAADASPDLRIALARWAIRNGVAADSELVVREDRHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQK7</accession>
    <name>A0A010YQK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3631"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="34305" checksum="1FE9EDAC3A3A3B61" modified="2014-06-11" version="1">MTSPDVVAETTRSAPAGRPVLRCHELRKSFDGTAAVDGLSFTVAPGETYGLLGPNGAGKTTTILMVAGVLAADRGEIEVGGQPMTVRSVRAKRAIGYVPQETALYPELTGRENLRFFAGLYGLGRAAGRARVEDVLGVVGLAEKASAAVKTYSGGMQRRLNIAVGLLHQPELLILDEPTVGVDPQSRNAILESIEALSAAGMAVLYTTHYMEEAERLCDRVGIIDRGTLVAEGTTRELTGLVGESDRVRLAATGNLAAAADALRELPTTRTVTVGPDGLDVLDADARTALPGLLAAAARAGAVVRSVAVEEPDLEAVFLHLTGSRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRE1</accession>
    <name>A0A010YRE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852675.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3916"/>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_11"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="30448" checksum="5A0491157C25F7B8" modified="2014-06-11" version="1">MNAVLQYTVQGLAAGSFYALAALGLAIIFGVLGVVNFAHGAFYMLGAVAAAVLLDSFGLSLWWSLLVVPVLMFGFGVVVERLLVQWLLRLDPLYNFLLTFGLTLVVVELVKQRYGVSGLPYELPGALRGRLELAGVVLPYYQLFVLLASAVVCALVGLVMTRTRVGMIVRAATEKPELARALGINVGRWVTPVFGFGVALAGLAGVLAAPFRAITADMGNSFAIILFAVVVIGGLGSIVGAVVAGFLVGLVEAFGQAYAPTFAQILIFVLMAVIILVRPAGLFGRAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRK7</accession>
    <name>A0A010YRK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570690.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4009"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_3_11"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="34505" checksum="01EECF95658A0C81" modified="2014-06-11" version="1">MSATITLRPLPTASPWVGFGVRRVGRLIVSLWVLVTASFAMIHLIPGDPVRGALGPTAPAELVEARREALGLNDPLLLQYLNYLKGLFTGDLGTSLTSRLPVSEVVAQRLPATLLLAVLAFVVAVLIAIPLGVAMGVLTRRGHGRRSEVAFTTTSTIVATIPDFLIGVALVYLFGIRFAWFPIAGNDTPASYVLPVVSLAIGPAAILSRIVRVEMSAVLEADFVRTARAKRLPARTVYLGHALPNAVTGALTLGGLLLSAMVAGTVLVENVFAWPGLGSTIVQSILAKDYPVVQAIVLVYGVGVLVTNLVVDVILALLDPRSTIREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV34</accession>
    <name>A0A010YV34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bacterial cell division membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.31"/>
    <dbReference type="HOGENOM" id="CLU_029243_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="493" mass="52632" checksum="556A69F43C74D83C" modified="2014-06-11" version="1">MTASAAPRPAGGSDPALTSVIGRPDRPLANNQRNTELFLLIVSLVVVTGMSVAVQASVLGEISGNALALPGLLALLFFGAHVAIRFLAPYADPLILPAVATINGISVVFIRRLDLGRLTPDERLAAGVLSGEGSEALKQYIWATVAILGFVALLWLVRDHRSLARFGYIALFTGLVLVMLPAVLPSSLSEINGAKLWIIIPGLGQIQPGEFAKIALLLYFARSLVDNRDFLQIVGKYQTLKATPGFLFRAYAPIIGAWLVSLSILVFEKDLGSSLLYFGLFLVMLYIATNSWRWLVIGLLLFMVGAYSAFLVVSRVQLRVNVWLHPFDDPFDTGYQIVQSLLALGSGGLFGSGPGAGSPNLLSLYASTDFVFAAIGEEIGLFGLTALLMLYALIASRGIRAGLDVRDSYGKLLAGGLAFSITLQTFVIVGGVTKLIPLTGLTTPFLAYGGSSLVANWLIIALLIRISDAGRRPAKVKAPPLQLRDAPTEVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVF4</accession>
    <name>A0A010YVF4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_7_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="116" mass="12266" checksum="3848CBF453739378" modified="2014-06-11" version="1">MVEDEIWRLDVSVVDGTAWLRPQGDLDMETSPSLIRAAQREFAGGARRVVVDLSQITFVDSSGIGALVTLWRTIGESPGAFAISAPSRAAQSVLATTGIDGLIERVDSLAAPQGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVY4</accession>
    <name>A0A010YVY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ORF">CryarDRAFT_0315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847833.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.300"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_11"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="93"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="536"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="414"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="654" mass="71620" checksum="202D01A908E68A16" modified="2014-06-11" version="1">MTEEPAEATLSNLLKEERTFPPSAEFAEQANVHADAYEKAQNDRISFWEEAANRLDWSEPWHTALEWNAPFAKWFVGGKLNVAYNCVDRHVEAGNGDRVAIHWEGEPGDTRTITYSDLQKEVSKAANALHELGVRTGDRVMIYLPMIPEAAVAMLACARLGAAHSVVFGGFSADSLRNRIDDAQAKVVITADGGYRRGKPSALKPAADEAIAGTGVEKVLVVRRTGEDVPWTEGRDVWWHDVVDRQADTHEHTTFDAENPLFILYTSGTTAKPKGILHTSGGYLTQASYTHHAVFDLKPETDIYWCAADIGWVTGHSYIVYGPLSNGVTQVMYEGTPDTPHQGRFWEIIQKYKVTILYTAPTTIRTFMKWGADIPAKFDLSSLRLLGSVGEPINPEAWIWYRHHIGGDNAPIVDTWWQTETGAIMVSPLPGVTSTKPGSAQKALPGISADVVDESGKSVPDGGGGYLVLTEPWPSMLRGIWGDDERFKDTYWSRYSEQGYYFAGDGAKKDDDGDLWLLGRVDDVMNVSGHRISTTEVESALVSHPSVAEAAVVGATDPTTGQGIVAFVILRGEAKEGTDTAAELRQHVAREIGPIAKPRQILVVPELPKTRSGKIMRRLLRDVAENRSLGDVTTLADPTVMNLISAGLTGGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW20</accession>
    <name>A0A010YW20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, gamma/tau subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.346"/>
    <dbReference type="HOGENOM" id="CLU_006229_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="42192" checksum="D7AAD7E91F1C6670" modified="2014-06-11" version="1">MTVALVPGVFTDVIGQDEAVTVLARAAAAAGRIVAGEPVAAGEMTHAWLFTGPPGSGRSVAARAFAAALQCPRGGCGECNECHTTLAGTHADVRVVAPEGVWISVNEMRSLVLRAASAPSGGRWQIVLIEDADRLHERASNALLKAIEEPTDRTVFLLCAPSAHPDDVSVTIRSRSRVVPLRVPSAEAVAGLLTRRNDVDETTARWAASVAQGHVGRALRLARDPDAQARRRAVLAIPRSLTGIAACYNAAAALIAASNEEAAAATETQNADEKAALERALGAGGTGKGAAAATRGTVGQIKDLEKKQKSRTTRVQRDALDRALVDLAAFYRDVLMVRLGASVPLVHIDVEEMVRAAAARWEPESILRRIEAVLKCRTALDENVKPLIAIEALMVTLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW71</accession>
    <name>A0A010YW71_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ORF">CryarDRAFT_0428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848000.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.412"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_11"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="189"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="506" mass="56525" checksum="B417D90531BF4354" modified="2014-06-11" version="1">MTENSTAPDADGDAFDNDLPEQVRVRLEKRARMLAEGTEPYPVGFPRTSTLAAIRGRYVDLGPDEHTGERVSVTGRVIFIRNTGKLCFATLREGDGTELQAMLSLAQVGAESLEQWKALVDLGDHVGIEGEVITSRRGELSVFADRWILTTKALRPLPVAHKPMGEETRIRQRYADLIVRPEARRMVEVRTETVRALRDSLNRRQFLEVETPMLQSVQGGAAARPFITHFNAFDLDVYLRIAPELFLKRCVVGGIEKVYEINRNFRNEGADSTHSPEFTMLEVYEAYGDYDTMARLTRELYQEAATTVFGSTVVERFDGTEIDLGGEWQTASLFELVSGAVGEDVTPETPIETLRGYAEKHGIAVNPLWVHGKLVEELFEALCEEQLAGPIFVRDYPLDTSPLTRPHRSRPGVAEKWDLYIDGVERGTAYSELVDPVIQREKLVAQAALGAKGDVEAMQLDEDFLRALEYGMPPSGGMGMGVDRMLQVFTGRGIRDTILFPFVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXJ8</accession>
    <name>A0A010YXJ8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.949"/>
    <dbReference type="HOGENOM" id="CLU_036884_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="370" mass="39181" checksum="6CE7A1191A35C2F4" modified="2014-06-11" version="1">MQYGSPRAKKVATGIKIASVAALLAGGGAWVATDRAVTLRVDGEQRTVHTHADDVRGVLASAGVKVGDRDEVIPAVDAEVRKGDTIEVDRARKLRVTVDGTTKEVWVTAPTVDEALDELSMGRRDVKLSASRHTRLPLDGARLNVDTQKQVSVKADGRTTTATTYAATVRDLLAERGVTLDVDDRVTPTAVTRLVAEQHVTVQRIATKTATETVTIKAPVRTRKDSSLTVGTSRVVTPGRPGQAKQVVRYVYTDGKVTSKQLLSKTVVTAATTKVVAKGTKKVTSAYVPGGTGLNWAALAKCESGGRPGAVSPNGTYHGLYQFSVGTWQRMGGSGLPSQASASEQTMRAQMLYKAAGAGQWPVCGSRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXS8</accession>
    <name>A0A010YXS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848768.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1046"/>
    <dbReference type="HOGENOM" id="CLU_108513_0_0_11"/>
    <dbReference type="OrthoDB" id="1943830at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17882" checksum="0EA7C71C8EF62460" modified="2014-06-11" version="1">MRIYLPATLAMLREIHADSAVGPAPLTGFAVTPSLREWYLDDDEEVLEYAAFTQAARAALRLLDADPLAPRRRVVLSAEVPDNEVTLHPDLDRAVVRSTVPIPLERLASVHVDSAEAEPDVSAAAKVIMEADLGDEDAQFTVDGTEDHELEWYAVQEIPQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYM9</accession>
    <name>A0A010YYM9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="12" type="ORF">CryarDRAFT_1389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849148.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1363"/>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_11"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="34680" checksum="7836E6A893033CB7" modified="2014-06-11" version="1">MSLLSSTVAAIGPADAAAAAQARDRQARMTKPAGSLGVLEDLSIRLAGLAGQCPPPLPEPAAVAVFAGDHGVHAQGVTPWPQEVTGQMVANFLAGGAVVNAFAAQVGAAVTVVDVGVAVAPAAGAGLLERNVRRGTRDMTVEPAMTRDEAIAAIEVGIAVAGELVDAGHRALLTGDMGIANTTASAALVAAFTGADAAAVTGAGTGIDAETLAHKTEVVRRALARHDLDADDPIGVLAAVGGLEHAAIAGLVLGGAARRVPVILDGVIAGSATLVAAALAPDCLDAVVAGHRSTEPGHGVALDHLGLTPLVDLSLRLGEGTGAVLALPLVQAGVRALRDVATFDSAGVTEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ41</accession>
    <name>A0A010YZ41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1544"/>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="37643" checksum="5B19D4A77FD6159A" modified="2014-06-11" version="1">MSDGDTMTTTLIRTETGAAARRPGGPPFASPRRFAGLLGALTLALLVVVVLGVAIGAVRIAPGTVLDVIAHHLGLPVTGLDPIADQIIWTTRLPRAVLAVVVGAGLAVSGAVIQAVVRNPLGDPYLIGVVPGAGLGAVTVIVLGASATAGLSLSAAAFVGALVAFALTFLLGRRHGHWPPARLVLAGVAVGYLVSAVTYFLQTIATPNQVTRVLFWSLGSVSSARWEQLPLPTVVVAAATIGLVLQGRRLNALANGVEMAGALGIAVGRFQFGLMLVVALMTGTLVAVSGGILFVGLVVPHVARLLVGAEHRRMLLCSVLLGAVFLPLADIAARTVRAPVELPIGIVTAALGAPFFLWLLRSSHHGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZB0</accession>
    <name>A0A010YZB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849489.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1608"/>
    <dbReference type="HOGENOM" id="CLU_030130_4_0_11"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="33310" checksum="5262A1146829F69B" modified="2014-06-11" version="1">MYLRVAPSTDSPARTGPPERTPLTVGLVQTRWHPDPDEHRTVLLDGVLTAVEAGAQIVFLPELTLSRYPADTVPVGDATASAEDLDTGPTRRFVAAAARAAGAAVHASIFERHPGDDGLGYNTAFLVAPDGTLLGRRRKTHIPQTAGYYEDRYFRPGPNDPDAYAPVGYENARIGLPTCWDQWFPEVARLYALGDADLLAYPTAIGTEPDHPDFDTAPLWRHVIVGNGITNGLFMVVPNRWGDEGNVTFYGSSFISDPYGRVLVEAGRTGDAALVATLDLDQRRDWLTLFPFFATRRPETYAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZD2</accession>
    <name>A0A010YZD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacid CoA-transferase, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1628"/>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26285" checksum="4B7D2FAA055BDF7F" modified="2014-06-11" version="1">MVSSAAEAVADIAAGASLAVGGFGLCGIPHVLIEALHATGVDDLRVVSNNCGVDVWGLGVLLKDHRISRVTGSYVGENKEFARQYLGGELEVELTPQGTLAERLRAGGSGIPAFFTPAGVGTMIADGGLPWRYGPSGDVVVSSPPKEVREFGGQEYVLEEGIVTEFALVRAAVGDRHGNLVMHESARNFNPLVAMAGRITIAEVEELVEPGSILPEQVHVPGVFVQRVVGPVGVEGKQIEKRTTRPRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z002</accession>
    <name>A0A010Z002_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-rhamnose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849822.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1815"/>
    <dbReference type="HOGENOM" id="CLU_059875_0_0_11"/>
    <dbReference type="OrthoDB" id="283831at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="389" mass="42919" checksum="F343BEB4DCDF938E" modified="2014-06-11" version="1">MSRVTDVLNRQHIELPSWAFANSGTRFKVFPQAGVPRDPYEKVADAAQVHKYTGAAPTVALHIPWDKTDDYADLARFAQEQGVTLGTINSNVFQDNDYMLGSVTNPDAGVRRKATDHLLECIDIMDRTGSRDLKLWFSDGINYPGQDDIRERQDRLAAALAEVYARLGDHQRMLLEYKLFEPAFYATDVPDWGTAYAHTLTLGEKAVVCVDTGHHAPSTNIEFIVAVLLRAGKLGAFDFNSRFYADDDLMVGAADPFQLFRILFEVLRGGGFDRDPGAMDEIAFMLDQCHNIEPKIPGQIRSVMNVQEATAKALLVDREALAAAQAEGDVLGANAVFMDAYNTDVRPLLASLREEKGLDPDPMGAYRRSGYAEKIVAERIGGTQAGWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0C3</accession>
    <name>A0A010Z0C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase, coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850026.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1963"/>
    <dbReference type="HOGENOM" id="CLU_027579_7_1_11"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="435" mass="47870" checksum="AF2F623F877E2BD0" modified="2014-06-11" version="1">MTLDGSPYQGYLYAYPHKTAYRPLRPRPALREVWSAEPTDTLFLYAHLPFCEMRCGFCNLFTRANPPAEQVSAYLAQLRVQARRVADALGPVTVARTAVGGGTPTYLTASELTGLFDVLDTFGRGAAPTAVETSPATATPDRLAVLSERGTTRVSIGVQSFLDAEAHAAGRPQKRAEVDRALDTIRAAGIPELNVDLIYGIAGQTAQSWEYSLTTALRWAPEEVFLYPLYVRPLTGLGRRDADGSDPAWDAQRLALYRQGRDRLIAAGYHQLSLRHFRRVPSADDSSDYRCQDDGMVGLGCGARSYTTDLHYSFDYAVGVGQVRAIIDDYVRRPASDFDHAEVGYHLDEAEQRRRWLVKSLLRSEGLAPADYATRFGTPLGADFPELGELAERGWLEHGADLVALTAAGMERADAIGPWLVSDAVRSAMREHVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z219</accession>
    <name>A0A010Z219_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mycofactocin system RPExFGAL protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850807.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2551"/>
    <dbReference type="HOGENOM" id="CLU_159310_1_0_11"/>
    <dbReference type="OrthoDB" id="2043869at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023850">
        <property type="entry name" value="MftB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03967">
        <property type="entry name" value="mycofact_MftB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="104" mass="11159" checksum="52A65019B91001E0" modified="2014-06-11" version="1">MTAVPESPAALTSFDLDRAWGVHPSVAVRPEPFGALLYHFGTRRLSFLKDPTLLSVVTTLADHPSARAALAASGADVTQQRRLARALATLASTEMITERTEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z363</accession>
    <name>A0A010Z363_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851307.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2934"/>
    <dbReference type="HOGENOM" id="CLU_098677_0_0_11"/>
    <dbReference type="OrthoDB" id="1807879at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009781">
        <property type="entry name" value="DUF1345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07077">
        <property type="entry name" value="DUF1345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="22246" checksum="4A815050B81BDA5C" modified="2014-06-11" version="1">MTSKATYLFSRAIEALLLVIGLVTIAAEDTILWISLWDCVAVFYLATRMYRLRRSNRRGDDVWLSRSLGGRIGLAFTVLTSIIGIGTGITIATSGDGEAKWLASAVGLPCVILAWAILHFGYAERYAKTFFGADPANPPLTFPNIDKPTYVEFAYFSFTIGTTFSVSDVETRTSPIRLQVLSHSVLSFIYNTATIGIAVSVITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3F6</accession>
    <name>A0A010Z3F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851446.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_11"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="25157" checksum="496F193CC1DEAC9B" modified="2014-06-11" version="1">MTLSGSTALVTGVGAGNLGHHFVQQLLDRGARRVYATARRPELIDAPGAHVLRLDLTDHASIAAAAATAHDVDLLINNASMSSPGLALADGDPDLIRRQFDTNVFGTLQMVRAFAPVLAANGGGAVLNVLSAAAWATSDGLHVYAASKAALWSMTNSLRDELSGAGTFVSGLVFGMASTPVLKAFADAVAGAGALDALMTDPAVIVDRALRGLESGRTEILADQLAVDAKAALSGEGPSVYATLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK84</accession>
    <name>A0A010ZK84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335690_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="22622" checksum="93F6B1323C85FC2A" modified="2014-06-11" version="1">MDVLEKARARRTAARAAAERAALDWQDAVVESIDQLVDQLRLAGSDRLVCFEAAVRPALDGEAWEEREDLVKAAFASDAGVQRYTPSDDERWAIAVDLWDDLRSALSRIHGTDVPASLVVDLDSRVAVGYEPLHCPDVGIEPELILHLVRADSDEPFASLLLELPDPDSAIDRVSELLDRYGLEPPTRPEHEPGECDLGMGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL30</accession>
    <name>A0A010ZL30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomeric repeat-binding factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265193_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="22665" checksum="93D9BF6C3F92F1F1" modified="2014-06-11" version="1">MEKPDPPTFDWTPPQERRNNLVALALGVCGVVLFGVCGVGLWIADGGPANDPKPTATSAEPTLVAAPPSQSPPNDHVVETLGSGVPQLGTRIRHGALEYRVTEQRCGVPEVGEDAGEAGQPTRGHFCVVTLDVRNLGRSAMVFTASDQIAYTTAGGRYLGSAKATRYANGAERTFLTPIGPGARVSGKIAFDMPKGSRLDSVRLRSAAAAGSVAVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL69</accession>
    <name>A0A010ZL69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="8" type="ORF">CryarDRAFT_0434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848014.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.418"/>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_11"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="68"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="354"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="470" mass="48919" checksum="BA2A18A11589945F" modified="2014-06-11" version="1">MPPRNRDRPAYRCTECGLTVPKWVGRCPECQAWGTIDEVGAGPVALQQVGPGPVTTPARPIGEIDIRAAKARPTGVDELDRVLGGGLVPGAVLLLAGEPGVGKSTLLLEVAHRYAAGGGAPALVVTGEESAAQVRLRADRTDRVHPALYLAAETDLSALLSHVEAVSPGLLVVDSVQTISSPALDSAPGSVTQVRAVTAALIASAKARNMATILVGHVTKDGNVAGPRVLEHLVDVVLHFEGERHSTLRLVRAVKNRYGPSDEVGCFEMFDGGIRGLADPSGLFLTRHTEAVPGTCVAVLLEGVRPLLAEVQALVAPSNLNNPRRAVSGLDSARVAMVLAVTERRGRVRLSERDVYTATVGGARVTEPAGDLAVALAVASAARDYALPPDLVAIGELGLSGDVRRVGAVERRLAEAARLGFRRALVPTGSIERKPKGIAVTEVDDLRAALGHAFADKVRSLSAAASAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLN8</accession>
    <name>A0A010ZLN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+ transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848317.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.607"/>
    <dbReference type="HOGENOM" id="CLU_026974_3_0_11"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458349" evidence="1">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="376" mass="39420" checksum="7764E1633C80333B" modified="2014-06-11" version="1">MRIQLAALTTAAALTLAVSACSPPTEDNSSDGSDTAKAATATSAKDLGSLDELVKAAKKEGELNVIALPPDWANYGNIIKAFEGKYDIKVNSAQPDASSADEITAAKSLKGQDRAPDVFDLGSAVAVANTDLFAPYQTEKFADVPADLKDPKGTWVNDYGGYMSIGFDSSKVPAPTSLIDLLKPAYKGKVALNGDPTQAGAAFSGVMMASVGEGGSADDIAPGVQFFKKLKDVGNFLPVDPTPATIESGQTPVVIDWDYLNVSQGEKLKGKTEWKTVVPANAVVGGYYVQAINKDAPHPAAARLWQEFLYSDEGQNLWLAGGARPVRAESMEKAGTIDKAAFAKLPAVTGTPVFPTEAQNTKAKEYLAANWAKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLQ5</accession>
    <name>A0A010ZLQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate O-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848337.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.621"/>
    <dbReference type="HOGENOM" id="CLU_015407_1_0_11"/>
    <dbReference type="OrthoDB" id="580383at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102420">
        <property type="term" value="F:sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044255">
        <property type="term" value="P:cellular lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="PTHR12563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="5">
        <location>
            <begin position="245"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="765" mass="86163" checksum="3F23EED16EAE8619" modified="2014-06-11" version="1">MSGTLYLVQSETPQERQIIANWLTTQFEGRDDDGGRSVVDLADERLHDLLADADDLLVEPLRVVWLPEDDDEKPLSRLGAALARRGNRRARSGAQRLIMRSGTDRYRVLVAKPATVGDLRSRWESSGSRERFGRFVERQAVLALDRAERALIGSQYKVARYVVEEITASPRFRTGVERLADELDLPVDEVQQRALAALNQMVAAQSRRAIDAWNRLGRYFARAYKLVVDDQKADSLRSLGQKYPLVFLPSHRSYLDPLVLRPALLAHGLPLNHVMGGVNIDFWPVGPLTRRSGYVFIRRSIADDAVYRWVLREYMGYLLSKRFNLEWYIEGGRSRTGKLRPPRYGLLTYLAEAFRSSGVEDVYLVPVSLSYDQLYEVGLMAEEAHGGTKPTESFAWLLRFNRAQDNQRGVVQVRFGEPLSLRDALADEPDTRLAVQKTAFEVSHRINEASPVMPRSLVTLALLGIEDRALTVVEVASVLDPLVAYFSSRELADRAALGLADERGVRQTLDDLASAGVVERYDRGTEPVYRVGPDQHLVAAFYRNNTIHFLITRAVAELMLQAVSEASPSPDDVLEYGWQAALALRDLLKFEFFFSDKEAFRTELHRELALIDPSWRSRISDPDGAATLLGSLRVHLAHRVLQPFLEAYWVVAQRLAARDPRTPVETKAFTRECLDVARQLRMQQQLASTESISGELYATALKLAANRDLVDPGREELRTAREAFAAEIEAWVRRVRAVRALALAEPDQVAPTVTLSARRPGVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLS2</accession>
    <name>A0A010ZLS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.636"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="829" mass="87850" checksum="2CF9DD1F110F993A" modified="2014-06-11" version="1">MRTVGDFPDLPIRPALPHIVDALADGGAAVLVAPPGSGKTTLVPLALAERVEGRIVVAEPRRVAARAAASRMASLLGEPVGETVGYTVRGDRNVGRRTRVEVVTTGVLVRRLQRDAELPGTNVVILDECHERHLDSDLGLAFTLDSRAALRPDLALLATSATAASEQLAAVLGGAPVLEVPGSPYPVRTEWCPPPAPLVGRSDPRLLDHVAAVVRRALGEATGDVLVFLPGIYEITAVARRLAGTDVPVVTLHGRLPAREQDAVLRPGSVRRVVLATAVAESSLTVPGVRVVVDAGLARVPRLDQGRGLGTLVTVAVSRAVATQRAGRAGREAPGTVYRCWSESDHARLPAWPEPEIASADLTAFALDLACWGTPTGEGLALPDQPPAAAMEVATSTLRALGAVGTDGRVTRRGRVLAGMGVHPRLARALLDGAPAVGERRAAEVVALLADDTLTGNRGDLIAARRALRDGSLPAPARRWRDEVKRLTQALPADARSAEGRRNDRALTDDLAAGLIVGMAYPERLATARQPGGRTYLMAGGTAADLGEGAGLSGAAWLAIAVADRSLGHANARIRLAVAIDEATAVEAGAALLASENEVRWHDGELVARTVDRLGAIELADRPLDPAADVRAEAVLVGVRKEGLNRLRWDTDARALRERLAFCAAAIGPPWPAMDDDSLLARADEWLGPDLISVRRRADLQKIDAGTALRRLLPWPEAARLDDLAPERIQVPSGSRIRVDYRDPSAPVLAVKVQEAFGWAATPTVSGVPVRLHLLSPAGRPVAVTSDLESFWRTGYPSVRAELRGRYPKHPWPEDPTTAVATRRTNVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMF3</accession>
    <name>A0A010ZMF3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848624.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1841793_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="15395" checksum="CB3A0E3C9A9C15F3" modified="2014-06-11" version="1">MAVLTKHRRTYTLDGSRVELWRSLRRGSLIIDDVVVPVEVTSFRRLAVSAGAVRLGPSGAMLPDGPAGWEVTRRSVSVVRDGARIDVREEGFLRKTTTVDVTGEWADRELIVLTAAFALLARQRRRRMIMIVAAASNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNU2</accession>
    <name>A0A010ZNU2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849194.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1395"/>
    <dbReference type="HOGENOM" id="CLU_151909_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="94" mass="8036" checksum="EB00CB25A6976513" modified="2014-06-11" version="1">MAINDDDIVTSGSGRAEGTADGGANPGGHDGGADGGADGGAEGPADGGANPGGHDGGADGGADGGAEGPADGGANPGGHDGGADGGADGGASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNX6</accession>
    <name>A0A010ZNX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA/RNA helicase, superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1436"/>
    <dbReference type="HOGENOM" id="CLU_003041_27_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="244"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="553" mass="56196" checksum="CBC6E0DC065DD2B1" modified="2014-06-11" version="1">MLSAEQSHSPARTFLDLGVPAVVVDALAADGVHTPFPIQTATLPDTLAGRDVLGRGRTGSGKTLAFVLPVVSRLATAKAPRRAGRPRGLVLVPTRELATQVHAVLRPLADAARLTTTTVFGGVGLGKQISVLAGGIDVLVACPGRLEELIRMGHCDLGGVEITVLDEADHMADLGFLPSVKRLLDRTPTNGQRLLFSATLDNGVDVLVRRYLHQPVTHSVDPAVAPVATMEHHVFQVASDTKADVVRQLASGRDRSLLFTRTKSGARRLARSLTAAGVPAVDLHGNLAQNARERNLAAFTSGAVKVLVATDIAARGVHVDDVALVVHVDPPAEHKAFLHRSGRTARAGASGVVVTIATPDQQSDVRALARRAGIAPKTVAVRPGAAEIVELTGPPAEPVTPQAPAQTATAGRGRGGAATDSRGGRAGESPAGAGRSRRGSGGRGAGRGATHEAPVAAGQRRTAPAQRDGAAPAGRSSAGGRGGAAHGGRGATGENGGRGGANGRSRSGAGRSGGSVYTSDSNGASGYTAGGAAAHSERGGGRRRRGSGPRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPH2</accession>
    <name>A0A010ZPH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849533.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1634"/>
    <dbReference type="HOGENOM" id="CLU_138549_2_0_11"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="13825" checksum="5131774EC44D7057" modified="2014-06-11" version="1">MDVLETLRRICLALPEATERISHGAPTWAVRDKRTFVTFADHVHGDEHVAFWCPAPPGVQEEMVAVEPERFFRPPYVGPSGWLGVRLDGPDVDWDEITEIVTEAYRCVAPKTLVARLGTVIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPJ9</accession>
    <name>A0A010ZPJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849567.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1664"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_2_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="267"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="512" mass="54601" checksum="426F3010B9B63AF8" modified="2014-06-11" version="1">MTLHVEAVSKRFLGVLALDRVDLVLRAGRVHALVGENGAGKSTLIKVMTGVHRPDGGRITYRGEEVGFAAPRDAQAAGISTIYQELNLVAAMSVARNLFLGREPLNRLRLIDFPAMHREAQAVLGRYGVAVDVRRALGEFSTGVQQMVAIARAVSTRARVVIMDEPTSSLEPREVDRLAQVIDLLRADDVAVLFVTHKLDEVFRLCQDVTVLRDGRRVFHGEVADIDRLGLVATMLGRPADEVRAHGLTSFGDGAGAGRGDDGVAVLRADDLTRRGALSHVSVDVRPGEVVGLAGLLGSGRSETVRAMFGAEPVDSGTILVGGKPTGRRWSPARAIAGGIGLVSEDRKVEGIVPDLSVRDNLVLAALPRLARAGFVSRRRCDALVDTFVRRLRIKMTGPDQPVRELSGGNQQKVLLARMLCLSPQVLLLDEPTRGIDVGAKAEIQALIDELAGAGLGVVLISSELEELVEGATRVFVLRDGAVVGSLAGDAISEHRIMTTIAAAAREEATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPK4</accession>
    <name>A0A010ZPK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849578.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971926_0_0_11"/>
    <dbReference type="OrthoDB" id="2103160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="31097" checksum="84F1F37AC50888DA" modified="2014-06-11" version="1">MDDHALERRYARVLRLYPAAYRRDRGSELMATLLESAGDRTRPSANEVGSLLLGALRAHAGPEPRSVRSSRRTVYRVAALTLLVSAVASAPVRIAADLASGAPVNQWLFAYDVPDLVASPLVLIALVAALRGSYRTAVASAVGAAVVNASFVALTSAGASGEFLLHLGAAAMLLPLVGEAPRPASGLLRYLPLAPIVLLIADRVALGASSEVAAVLYVVGPLVLSALAALWAAVDERVAMAFGLVLLSELLLRAVVLAAFVAQAGMPTTPAEIGRQAVLAAVGPALLLSVSAVAVRRRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ27</accession>
    <name>A0A010ZQ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP family phosphohydrolase, histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849805.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1806"/>
    <dbReference type="HOGENOM" id="CLU_069822_0_0_11"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="37375" checksum="0604F32C68B4E94F" modified="2014-06-11" version="1">MTDATRDPVADLRRIAFLLERAHEATYRVRAFRSAAAAVEKLDADELSERATAGTLKKLPGIGDVTARCVAESLAGEEPVYLRRLEATAGTSVDEAGAELRALLRGDCHTHSDWSDGGSPIREMAEAARSIGHQYVVLTDHSPRLTVANGLSAARLREQLDVVAELNRELAPFRILTGIEVDILDDGSLDQSDELLARLDVVVASVHSKLRDPADTMTKRMLAAIGNPHTDVLGHCTGRLVTGRESTGQGKRPESQFDADAVFAACAERGVAVEINSRPERLDPPKRLLRLAVEAGCHFAIDTDAHAPGQLDWQPYGCARAAQCGVDPARVINTWSAEDLLAWTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ55</accession>
    <name>A0A010ZQ55_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="7" type="ORF">CryarDRAFT_0360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569600.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.345"/>
    <dbReference type="HOGENOM" id="CLU_008049_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Thymidylate_kin" evidence="6">
        <location>
            <begin position="460"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="462"/>
            <end position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="758" mass="78140" checksum="2818F0BBBB8C31DB" modified="2014-06-11" version="1">MWLTFGLSSFGDWLGLLATSLFAAGQVSGPTAKGLAFGGVVIARLLPTIVLGPLAGAFADRFDRRLTMVVCDLVRFVLFASIPLVAVVGSAPVAVGWALVATFVIEVVGMFWNPAKEASVPNLVPRDQLEAANQLSLIVTYGVTPLLAVFIGAGLNRLLLSLVRDDPSRLRLDPNDAALYLNAFTFLVAAVVVFTIREISTGEGRLRRSGPAGVPEPSLPTALLDGWKYAGRTPLVRGLVLGILGAFAAGGVVVGVGQFFARGLGGGDATFYLLFGSLFVGLAGGMGLGPSLVRGLSRRRWFCASIGLSGLAVAVLPFSLHLSMAIPLTVLAGAGAGMAYLAGTTLLGAEVPDAMRGRVFAFVQSTVRVVLLLAIAVSSLLVGVGGGRKIPIGAFDLDFSAARVLLFVSGLLAIIASVLSFRAMDDKPGVPLLRDLYSTLRGHSLPVAGDRSGDGLFIVFEGGEGAGKSTQSRALTDWLTGRGFEVVSTREPGATPLGREIRSLILDHRDDAPSSRSEALLYAADRAHHVATVIRPALARGAVVVCDRYVDSSLAYQGAGRDLATEDVEWLSRWATAGLVPDLVILLDVDPSIGLTRVGNRGVADRLEAESMDFHQRVRRAFLDRAAADQRRYLVLDAGSSAGMLADRIKVRVAPLLKVHPDINEPLPQAPAVPASVGASSSVAADAPGAAPASASGSTAEAGPAAGPTAGLADGLAAGPEAGPVAGPATGPAAEARPDEGGGDIGSKTDPGSSAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR47</accession>
    <name>A0A010ZR47_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848457.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.711"/>
    <dbReference type="HOGENOM" id="CLU_131550_1_0_11"/>
    <dbReference type="OrthoDB" id="1903180at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="78" mass="8320" checksum="FAF9020BEE5ECCB8" modified="2014-06-11" version="1">MHHLYNGIPAGQLGPVAWLKSSHSNPNGNCVEIAGLPDGQFAVRNSRHPEGPALIYTRDEIAALIAGARSGDFDHFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRL4</accession>
    <name>A0A010ZRL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850508.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="230" mass="25001" checksum="AE3CE5B6FC66DA01" modified="2014-06-11" version="1">MARKRADAAVKERLTRERIVDCAIALAGAEGLEAVTIRRLAQDQGVTPMALYWHFKDKDRLLDGIAEKVLSDVTLPAGSGGPWHEQLRHLLSELLTVLRAHPAVADLVKTRFLLSEPGLQLAERALGLLRGAGFTPEQSAQLSGHALQTIVALVTQEPGLMVGEDPAAREDHIRLKRASLQALSPDRFPNMVASADAFTDCGNEPAYFELGLDLFIEGVRGVQPGQSDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSE6</accession>
    <name>A0A010ZSE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851009.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_0_11"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27494" checksum="39D4F0D6D2CC5642" modified="2014-06-11" version="1">MVSDGTEGAGRVADVLLRFVDGPQSWGVSAMARELDLSKAVVHRIMRSLVDRGLLTLDSTSRTYSLGPAAAAIGARALRDSKLRRVSLPLLRELQVTTGETTTLSARVPGGRVYLDQVVSTHEINMTVELGRRFPLHAGGSGRAILAFFPAGEREDVLHGELRTLTSATQVDPEQLRTLLTETRKNGVAESGGERQPGAGSVAAPVFDLDGQVIGSISVCGPINRLTAEARRTYVPHVVQTADRISRALGWPGGLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSH3</accession>
    <name>A0A010ZSH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homoserine kinase type II (Protein kinase fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848967.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1219"/>
    <dbReference type="HOGENOM" id="CLU_044821_2_0_11"/>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="34972" checksum="CF509785F8E857CF" modified="2014-06-11" version="1">MIASSAAARYGLSPDTTIELLNVSENETYLVREPDAEPVVLRVHRLDYHPPGAIPSELAWLDALRTEAGVRTPRVIPALDGARVVTVPDPSGGPARECVLFEFLPGREPREDDLVADFEPLGALTARMHVHARSWTRPPGFVRFHWDADAAFGTAAGPGRWGAWRSAPGVGPAEEAVLARLEATLRERLRRFGTGPERYGLIHADLRLANLLVADGVSVIDFDDCGFGWYLYDLGAALSFVEHLPEIPEVIDAWLRGYRSVTPLPADDEAEIWTFVLFRRLLLTAWIGSHSTVDIAAQLGAGYTRGSCALAEQYLSTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSK1</accession>
    <name>A0A010ZSK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar diacid utilization regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851090.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2755"/>
    <dbReference type="HOGENOM" id="CLU_017436_7_2_11"/>
    <dbReference type="OrthoDB" id="1452079at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="317"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="40604" checksum="E53225931FA57122" modified="2014-06-11" version="1">MTALDDLVDDMAGLLDAPCTLEDPDFRLIGFSGQGRAGVVDEVRRHSILERGSTPEVREWFLAHGIHEATGPVRTPADPARGIAARLCIPARHLGRVHGYFWLLEDEHPIGVEHWGEAARIAEAAASLLGLVERRQARRDANYREAVEGHGGAAAHSALELASAAGLDVRDPVACVLVHRPDLGGQLASRSTRSGLVWVREDNVVCAAVVHADLIRSATTLPTTLAALGLGRRLSSLDDSTWVGVGPVVSGLAELAASRTGARVALRVARASERGTVVEWGGLGPLGLLGVARDDDLARTLLTPRLRRFLDEAPGALVETARVYLDEAGSVARAAGRLSVHRQTVYHRLAQIEHLTGCDLSTGEGRLRLHLALRLAPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSU5</accession>
    <name>A0A010ZSU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159294_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="12983" checksum="A3AEF117B12FDDAF" modified="2014-06-11" version="1">MAVNGLPNVLHLDSTQVGFLALSAPEARVDQAGRAVVDKQTGLPLFRVQIALLHPNEPAGLVSVTVAGQPEGIAPATPVTLTRFTGRPWIGDQGNWGIAFRAETLAPLDGETRRRHSSPSSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSX9</accession>
    <name>A0A010ZSX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862316.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2866"/>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18710" checksum="F93F613F78196314" modified="2014-06-11" version="1">MRPDFGSYLEADGATLLRFAYVLTGDHHLAEDLVQEALVQVHRRWARIEEPRAYVRKAVLRHYLSWRRRRSSDEIPARDAVWRSTAQDDHAERVVDRDALWSALATLPRQQRAVLTLRFYSDLDDAAIAELIGCSAHTVRGYASRGLARLRESAAVLQSVRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTB8</accession>
    <name>A0A010ZTB8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849366.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098224_0_0_11"/>
    <dbReference type="OrthoDB" id="1620747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="25827" checksum="80C19B43A67E96E2" modified="2014-06-11" version="1">MSSTDAKLAVIRKLLAQAEDAAASPAEAETFTAKAAELMARYGVDRAMLADGDETADGIADREIPVDPPYARDKFGLLAGIARAMGLRVVHKSGYRGRDTTALLFGFASDIERAEILFTSLLLQAVRGVLAARVPPGEHVAAYRRSWIVGFSATIHHRLAEAEERARAQTTSTSAAGRSAEVVLADRRRVVDTRFAEAFPRLGTMGPRYLSGSGHREGAAAGHRADLGVTSLRSRQGVIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTH5</accession>
    <name>A0A010ZTH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849469.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1579"/>
    <dbReference type="HOGENOM" id="CLU_084739_0_0_11"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="243" mass="26097" checksum="CFECA974796A32C6" modified="2014-06-11" version="1">MSHPFEIHGEITVDATPEQVWDAITTGPGVDSWLMGRTVVDGDGKTSTFEMFGSTSTANITTWEPGHRYATAEDKNPDGTFTAFEWLIEARDGGGAVVRFVHSGALGDDWEAEYDGLSVGDQAYLTKLAVYLEHFAPRTATHSTFLPGPVTEGSWAAMTAAVGAGTDAADGQPARLTVPGIEPVEGVVEFVHATSFVGMRTGDAIYVLIHGYNGMMFATAHYFDDRDRSAEIEAWQAWLGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTN9</accession>
    <name>A0A010ZTN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862999.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3161"/>
    <dbReference type="HOGENOM" id="CLU_010194_17_2_11"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="23583" checksum="41FACECA24880CC1" modified="2014-06-11" version="1">MPTIAIIGAGPGLGLSIAKVFGRNGFSVALVARTQEKLDSLAAELGEAGIDAAGFAADIMDRPSLTTALVRIKERFGRVDVLEYSPAPHNPVPGITMAGPLDVTVDNLQPQLDYYLYGGIAAAQQVLPDMIERDSGTLLFTTGGSSVDPLAAPPEFATVAVGAAALRTWTLKLHQATAGTGVYAAHVPIFAWIGAGGPETQADAIAQHYWDIYTKRDGAEHPYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTT5</accession>
    <name>A0A010ZTT5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849593.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1682"/>
    <dbReference type="HOGENOM" id="CLU_087298_0_1_11"/>
    <dbReference type="OrthoDB" id="1478254at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="171" mass="18967" checksum="9987FDA724A7D037" modified="2014-06-11" version="1">MDPRPLLGEPLPLDLVNTRWTDDRGAHDLLELPGGLAIWLSSAGLADTVPESPETLDALRATRDALARGDADRLNETLRHGRIGRRLGPDGPENVVETDTPGWLAAWLAAEHYLRLLEQDPSRIRDCANPGCTLRFYDVSKAGARRWCSMAACGNRAKARSHYARQHRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUE6</accession>
    <name>A0A010ZUE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849903.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1875"/>
    <dbReference type="HOGENOM" id="CLU_029972_1_2_11"/>
    <dbReference type="OrthoDB" id="1207398at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05804">
        <property type="entry name" value="StaR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033891">
        <property type="entry name" value="TTC38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16263">
        <property type="entry name" value="PTHR16263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="459" mass="51162" checksum="CEB2EF6BF2C22552" modified="2014-06-11" version="1">MGVDQHGLPTTVANRAALDHYDRAVDELLHFRAEVVAESGAALDEDPTFPMAVALRAYLGLLTTDHDDAVAARAYLATYRPGETHPRERAHLHAANQLAGGDFHAAGRTLRDLTVEYPRDALALAVGHQIDFFTGDAVSLRDRIGGALSAWHPDDRHYPNVLGMYAFGLEEAGHYDRSEDVGREAVDRDPRDVWGIHAVAHTYEMQGRFGDGLRYLDDRLDDWSKDTFFNVHNWWHYGLYALEKGDNARALEIYDTVLYDPDGISLQLLDAAALLWRFALAGDRQTARFAALVEPWQRRAEHPFYAFNDAHAVMAYVGAGRFDLAEALIRSRTEWIDTEQQGSNHAMTARVGLPVCRALLAFGQARYEQTVDLLYPIRDHVNEFGGSHAQRDAVYKTLVEAALRAKKLPLARTLISERLNVRPCSPYNWLKQAELARALGEDAAATAAQARASAYQGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUM5</accession>
    <name>A0A010ZUM5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850024.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1962"/>
    <dbReference type="HOGENOM" id="CLU_071824_0_0_11"/>
    <dbReference type="OrthoDB" id="1311927at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="282" mass="31550" checksum="C9620AB86FD8720A" modified="2014-06-11" version="1">MDLSILYRGPLASCNYDCAYCPFAKRRDSPATLAADRAALERFTDWVTRNPDDDRISVLFTPWGEGLTRSWYRRALADLSRLPHVGRVAIQTNLAATFGWMADANLDRLALWVTYHPTQISRGRFLARCSTLHSRGVRFSVGIVGLPAHYEDAGWLRTALPDDVYLWVNAAEGHVYTPGEERAWAAIDPLFSYSARPHLSAGQPCRTGDTVLSVRGDGSVRRCHFVDEPLGNLYDGSYRRALRPRSCPLATCDCHIGYVHLETLPLYDVFAGGVLERIPMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUP7</accession>
    <name>A0A010ZUP7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850062.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1992"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_11"/>
    <dbReference type="OrthoDB" id="1650261at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="15679" checksum="5D5C259DF5BA4888" modified="2014-06-11" version="1">MTQQTRPTVVKSDAEWRAQLTPQEFHVLREAGTERAFTGEYTDTKTIGVYHCRACGTELFRSETKFESHCGWPSFYAPSEAKNVVLIEDTTLGMRRVEVRCATCDSHLGHVFHGEGYGTPTDDRYCINSISLTLEPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUU7</accession>
    <name>A0A010ZUU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3620"/>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="13884" checksum="B9638F04B95CBF80" modified="2014-06-11" version="1">MPSRSADETAGEGRREPRPDPPLYQLKAEFFKTLGHPVRIRVLELLSIRPHAVSEMLPEVGVESAALSQQLAVLRRANLVTARREGSAVYYQLATDDVAELLRVARGILTGVLQGQIELLAGLRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVK1</accession>
    <name>A0A010ZVK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation enzyme/thioester reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3888"/>
    <dbReference type="HOGENOM" id="CLU_227422_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2055"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2584"/>
            <end position="2659"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1050"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2090"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="2683" mass="286696" checksum="2C41E625421AE293" modified="2014-06-11" version="1">MASPVADRVFTLDPRRRSALAALLGARTGPGAIPRQPRDGRTFPCTPAQVRLWLADQLDTGAVAVPNATAGLRLHGPLRVEALRSALAEVAGRHESMRTRYGVSAGVPHQIVAATAPAPFDVVDLTGSPADARSAAASAVTAEAAAERFDLATGPLFRLTLCRLSDQDHVLLFAGHHIAFDEQSVDIVLRELAAGYAAPAGGDPGGELDYVDYACWVAGQEVPAAADEYWRERLAPPLPDLDLPFLTPARRRSAAAVPGPAEPGAAAGTESVRVRLAAGRLDRLRAVTGNQTPFVTLLAVLDVLLARYTGSADVTVGTVSAGRARTELEPLVGCFLNPLVLRTDLAGAATFTEVVHRVRATVAEAFAREVPFDLLAGRTPRRPGIHPLFQAALHVHRHRADEGAWPGLTTEVWHHEVGADALDLTVEATPLPDGTTDLTFRTPRGAAEPGAIDRFAEAFRTLVDAVGEAPDAPLADAGRAPRADREVLRRWNTTSRPVPSSTVAALIAERVTRTPDAVAVVGAGLTWTYADLGREVSALAARLTAAGCRRGTLVAVCLERSPWLVVATLAVWRAGGAYVPIDPEYPPDRQALVLSDSHAALVVTRRAQDTHLPPTPAPIIHVDEPRPAPVVEVPDGPEPDDLAYVLYTSGSTGRPKGVAVEHRALGNLIADFGHRLAAGPADRWLAVTSLAFDIAALELYLPLVTGARLVVADEASARDGRALGDLIRREGVTHVQTTPSRWRLLLAGGFGRTDPSTVDRAASVGPGSARAVTALVGGEALPPGLARDLRARTGRLLNVYGPTETTVWSCAWEVPADVDEVVIGTPLANTRIQLRDPDGHLVPVGAPGELWIGGLGVARGYLDRPGLTADRFRPDPDGPPGARLYRTGDLARWRGDGQLVFLGRTDDQVKLNGHRVELGEIENRLGGVEGVAAAAVAVTGDVAGERALVAYVVPVPGASWDPGLVRAALARALPDAMVPRRYVALEQLPLTPNGKLDRAALPAPDLTPETAGYRPPGTPSEHVVAAVFAEVLGHDRVGADDDFLALGGHSLLAMTIAALLSEHFGREVGVASVFTWPVVADLARELDRTHADRTRATMARRPIEPRPTGSGPAPLSLGQQPLWFLHQLDPADASYNMPLVYRCAGPIDPDALDRALTRVVARHEALRTRFGLVDGEPALLVDPPADVTAERVDLSAAPDPVLAAHERVAGWTNAPFDLERDRPIRAGLIRLGPDDHVWCLVVHHIGGDGQSLALLVEEIRHAYDGAPRPDFPVRYSDFAAWERAVVRDGEDDAFAYWRDRLAGVPVLDLPTDRPRPPLPSTRGAFVRHRLPIELTEAVERLAVARRSTLFVVLLAAYQAVLSRLSGQTDFCVGTSASARVRPEIVPLIGMFTDTLALRADLSGDPTFADLLSRTRHTVLGAFGHPRIPFERLAAAWHLPRDASFHPFFQTMLIVHTEDAAGVDVVPGVRAEPFDDGVTQAKFDLMAECWRDPDGLDVALNYRTDLFDAATMTGLAERLEALLRAAVAAPDRPLSGVELVSSAERSRLLALGRGASADDDPADVVALVAERVRLDPDAVAIVDGDEQLTYAQLAGRARALAARLRALGVGPEVPVAVALPRSAELIVALLGVLEAGGAYVPIDVGYPPARIEFLLRDSGATVLVTDSPHDHFPPVDHLVLPGDVLPGDVHPGRAEPTSAGPGAPAYVIYTSGSTGTPKGVVVSRGALAARVEWMRRRYALGPADQVVQFASVSFDTHVEEVWPALTAGARLVLLPPGQDLPELLDHTPVTVLDLPTPYFHELVPTLDRLHLPDSLRLLILGADQVRSDALATWRHRVGDRVEVLNTYGPTEATVIATAATLGGHDTDGRPPIGRPIDRTRLYVLDEHLTPAGSGELWIAGAGLARGYLGRPGLTADRFRPDPFGPAGTRMYRTGDRVRWRADGQLEFLGRLDDQVKIRGYRVELGEVETALAAQPGVRQAVVVPRTDAAGHRTLAGYLVGDADPADVRAGLAARLPAYLVPTHLTAVDEIPLTGNGKVDRRALPAPDPRQDTGYLAPRTPTEELVAQVWAAVLGLDAVGMHDDFFALGGHSLLATGAVARLCTVVDCDLTVRTLFGAPTVAGLAAAIDRLRTRPGTADRPVVARPAGAGPAPLSLGQERLWFLHQLDPDDASYSIHLAYRLRGPVDPARLEHALGVVVDRHDVLRTRFPEIDGEPVQDVGPATGVTLLRAGAAGPEEARTRVAEWVNTPFDLETGPPIRAGLVRISDDDHVLAVVLHHIAGDGRSAGLLAAELRRAYDGAELPALPVQYADFATWQRARTAGEELGYWTEQLAGVPPLELPTDRPRPPVPSSAGDFLVHDLPEPVVRAVRRLAAESSATPFVVLLAAYQVLLGRLTGSPDLCVGTPIEHRPRVEVADLIGFFVNTLALRADLSGAPSFRELVARTRDTAFAAYARQDVPFDRILGALDLPRDVGRTPLLETMFTLHTEDAAGTDVLPGVDAEFFDAEFRQVKYDLSLDAWRMPDGLRLVFGYRTDLFSRDTVGGWAEQFAALLGTLLSDPDGLVSGAERTRRAVRVPRGPVPYVAPRTAAEELVADVWAELLGLDRVGLYADFFASGGHSLLAMKMLARLRAATGTRIPLRAVFAHPVLERFAAAVEEALLADLADLSDDEAAALLAAEEEPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVQ0</accession>
    <name>A0A010ZVQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid/amide ABC transporter substrate-binding protein, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570650.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3915"/>
    <dbReference type="HOGENOM" id="CLU_027128_1_0_11"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458094" evidence="1">
        <location>
            <begin position="28"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="38"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="43951" checksum="FBC164150C5C0C7A" modified="2014-06-11" version="1">MKRKELLAGAVTAVLLLGACGQGGPGASGGKFTGDKLVLAVLNDQSGVYKDASGPNSVTAVKMAVADYRKKYGDKAVVDTIEVTSTDHQNKPDIANTKAAELYERGGADVILDVPTSSAALAVATQAKNHKKLFLDVSAATTALTGEQCNKYTFQWAYNTYMLAHGTGTTVTKNGGAKWTIIYPDYEFGQNMTKSFTDAITKAGGTVQNSIPTPFPNENFATFLTKAGSTRPDVIGTMHAGGDLINLVKQFNDSGLKEKGIELAVGLMLITDIHSLGVDQFAGTMFTDAWYWNMDAESRAWADRFRAETRTRPTFEHAGNYSAALQYLEAVQAAGTDDADAVVGELEGKKVEDVFLRNGEIRAADHSVVHDAYLVRVKKPSEVTEDWDYEEIVTTIPAAEAFAPASGCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWS2</accession>
    <name>A0A010ZWS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ornithine cyclodeaminase, mu-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851088.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2753"/>
    <dbReference type="HOGENOM" id="CLU_042088_3_2_11"/>
    <dbReference type="OrthoDB" id="1193876at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="344" mass="36941" checksum="865CD3F678DABC70" modified="2014-06-11" version="1">MNVPFVDVANLARWVTALGAERIIADLVTELELDFKRWPEFDKSARVANHSTDGVIELMPISDGQQYAFKYVNGHPKNPERGFQTVTAFGVLADVHNGYPVFAAEMTILTALRTAATSALAARHLARPDSATMALIGCGAQAEFQALGFRAVLGVDRLRIWDTDPAAMDKFERNATRLGFTVERAADAHDATLGADVVTTCTADKANATVLAAASVRPGVHLNAIGGDCPGKTELDPAILPRSEVFVEYTPQTRVEGEIQRQPADFAVTELWEVVAGLRPGRSGADAVTVFDSVGFAIEDFTALRYLQRAVEGTGYAVDLDLIADPRDPKDLFGFVTAGAFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX84</accession>
    <name>A0A010ZX84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851281.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2914"/>
    <dbReference type="HOGENOM" id="CLU_062618_7_0_11"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="66"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27448" checksum="032DE2B5FCC7E2BD" modified="2014-06-11" version="1">MQGRAVTSRALRLLGAFDAEHPRLRLSALARRGGLPLSTAHRLVAELEEWGALDREPDGAYVVGRRIWQLALLAPIHGELREIAMPYLEDVHRATGENVHLAIRDGGHSLYIERIWSRASVPLESKVGRRLPLHATAAGKALLAAAAPEVVEAALAAPERLTPHTVTDPAALRRDLAEVRSRGYAYSAGEATPGTWSIAVGVPGPLRTTLASLAVVAGGPDDPGTATGPELRRLAAVLMVAASALGRELGKTAWSRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXC2</accession>
    <name>A0A010ZXC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851343.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_7_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="17445" checksum="65642FC6DA72E204" modified="2014-06-11" version="1">MPLPKNPPRNPDSPFASVRPHHTAIRYPDFEDARSFWVDKLDWRVLQTWPYGDLTLAYVLPPDHDDFHLEILAGPGATTQTVFDDVDASLGESGFNHVCLEVRSVDATLAELRARGVDIVNEPFEIADISARLAFFRDPWGNMFELSERAVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXU5</accession>
    <name>A0A010ZXU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570292.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3129"/>
    <dbReference type="HOGENOM" id="CLU_154488_2_0_11"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="118" mass="12100" checksum="42AD36CCFCA64894" modified="2014-06-11" version="1">MSAAAADLRVVAVTITHGFHAVMTAQPGRGDELVALLLDAPSLPDEDCLVFLVSRSAGNPDVVSVAEGWSSEQAHAAFFAGDAAQTFVAKLQPLLDGESSYSDAVPVGGKPAFETSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYQ4</accession>
    <name>A0A010ZYQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160549_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458438" evidence="1">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="14797" checksum="A76D26181EBB99FA" modified="2014-06-11" version="1">MRAQGIRTSNSLKKAMLSTAVVATTVLAGGLFTASPATAEPDVRGCAWPKVCFYLSTANWISSSPTASYQDLTSGFQTLGSRSRGADFAYNSRNDDGAFLRFSSGITQCLPPNQFIDLGRMRASLGDVVGLRIMDSPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZA7</accession>
    <name>A0A010ZZA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852418.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3709"/>
    <dbReference type="HOGENOM" id="CLU_004665_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="27921" checksum="AB608DA9339A35FF" modified="2014-06-11" version="1">MSTAGLVQVSVLGPIEVTVAGQPLALGGPGRRALIATLALDVGTVVGVPRLLEAIWGDDPPATATTKLQGHVCALRQGLVRLGGPRAARVVRTRRPGYVLCAPDATTDLDAFENLVRQARNSPLPSGAARRAAALEQALLLWRGDACTDLSSPWVAAVAASLDERRRRATEDLAEARLALGEHDAVIDAMQSLVQLTPYRERAWEHLISAHLERGDFASALAVHDQLCRILAGDLGTAPGVRISRLIGAIRRPRADSTSLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZE9</accession>
    <name>A0A010ZZE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852515.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3758"/>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_11"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="21814" checksum="9751A54F3E20B024" modified="2014-06-11" version="1">MAGRFVYWMNVSLDLKIEHARGEEGGGSWLRIGEALHREFNARARALAMIVEGRTVRETMEAFWPDAREDRSLPGFLREYGEIWTSKPKVLVSRTRTEAGYDTRVIGGDGDAIEELARLRARTDGDLGVGGATLATQLLRAGLLDELLLFTHPVVLGTGRPLFDPHDEPIELDRLEQASFDEGVTLHRYAVRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZF9</accession>
    <name>A0A010ZZF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864719.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3769"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="36426" checksum="C560B071A205413B" modified="2014-06-11" version="1">MRPRSLWPSVVHVLTSLPVALGGAVLILPVLVVAGISGRPLRAVVAGRTAAQRRRFAALLDVGIAEVTAVRRQTGYHLLAVPVSAAGFAVVAGTASYGLALLVTSRPVGVVPVVVAAGAAPLLARLDAALARRLLGPTAAEALDARLAELARSRARTIEAADAERRRIERDLHDGTQQRLVALALTLGLARTALADGPGRDAVESAHRQAKAVLAELRDFVRGLHPAVLDDRGLDAALSGLVAGLPQPVELHVDVAGRCPPAIEAIAYFVVSETLTNVTRHAHASRVEVVVVRRGDRLRLTVVDDGVGGAAGRAGGGLEGLAQRVAAVDGEFRIESPPGGPTRVEAELPCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A054</accession>
    <name>A0A011A054_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4034"/>
    <dbReference type="HOGENOM" id="CLU_046006_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15780" checksum="39270ABF9507FE98" modified="2014-06-11" version="1">MTGLKRLDNVAIVVDDLEAAKAFFGALGLELEGEATVEGSEVDRLVGLVGVRSDIAMMRTPDGHARVELTRYHSPDTPADDPRAPANTLGAHRLMFAVDDLDAVLDRLRPHGAELLGDLIRYGDSYRLCYLRGPAGILVALAEQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0I3</accession>
    <name>A0A011A0I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725737.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_11"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="25721" checksum="5718FE7306714472" modified="2014-06-11" version="1">MFSAVHVPRDPAAAAQALREGGTVLAGGTYLMPRFNERAFPPTSVVSLRRAGLDGVEADGATVRLGAATTLATLEADERLAFLRPCLRAIASPPVRGLATVGGNLFVPQPYGDLAVALLALGASIEVHGGGRTPLDDGVPAGDLVTAVTFAVPDSFRFYKATRRRHNSAAIVSVAVNGDRIALGGVAPRPLRAHAAEAVLRADPGAVGPAAEAMREHLAPADDAYASAWYRHRVFPVHFRRALLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAP0</accession>
    <name>A0A011AAP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type Fe3+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.104"/>
    <dbReference type="HOGENOM" id="CLU_021838_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="335"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="539" mass="56441" checksum="1BF9C559DE82F82B" modified="2014-06-11" version="1">MDADGAPLRTRLLALVPLAFLGIFFVYPVGTLVAIGLGFGDPIPGVPRGSLGDVRGVLWFTVWQAVASTVLTLVVAMPGAAVLARFRLPGSALIRALVTVPFVLPTVVVGAAFLALIGPDGLLGVELDRTVWAILAAHVFFNYAVVVRIVGSVWAQLDRRSVEAARVLGASRLRAFVRVTLPALRPAIAAASTVVFLFTFTSFGIVQILGGPSYATLEVEIYRRTVYQLDLSGAAVLSMVQFVAVAVLLAVDAVLTGRQRAARLVPASPRSPRGFGEWAFVGVNLIVLVGLLLTPLAVLVERSFATSDGYSLTYWRALTSSDASSVLPAPALETVGTSLRYAVTATLLALVVGLCAAVVLTRPGRLRGAFGLLLMLPLGTSAVTVGFGFLVALDEPPLDLRDSALLVPFAQALVAVPFVVRAVLPVLRAIDDRLREAAAVLGTPPGRVWWRVDLPLVWRSLAAAAGFAFAISLGEFGATVFIARADNPTIPVAIAQLLGRPGEVNGGQAMALATILMVLCAASLIALDRLRPAGAGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABF2</accession>
    <name>A0A011ABF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847903.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.354"/>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="23948" checksum="00DCFA03828DA5FF" modified="2014-06-11" version="1">MRILVAEDESLLADAVAVWLRGEAHAVDIALDGATALERVGVNDYDVVVLDRDLPKVHGDDVCRVVAAQHPDVRILMLTAAAEIDDRVTGLALGADDYLPKPFAFRELAARVIALGRRARPAAPAVLQRAGIRLDPHRREVFRDGRYVPLSRKEFAVLTELLRADGTPVSAEQLLEKAWDENADPFTNAVRLTILKLRRKLGEPPVVLTEAGVGYRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABI2</accession>
    <name>A0A011ABI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462887_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="589" mass="63209" checksum="FA9EDD54B39A88FD" modified="2014-06-11" version="1">MPPPHLPPPERGESESAPSTPGFRRHVGKLFWVGVAIAPLAALLLVLGSGVGPLRAAAVLAVFSVVIIGLSVVLRDDAAMVKDDVEEQLRTEVTQLRNDIDSLRRGVEVSVHRELERVHRELEATRREGVLRAESTRLNRLTGALPAGEDDYPVDSRGRGDRPMRAIAAGGEIPDAEPGYDWFGSDETGAGQRQEPIRYGAGTYGSARPAGSSDTGDNPGNWPRRPAEPEPAASGRRAGGNEYGGTEYGRRRPDADDSAGRYQSYQASTYGSGTGGDAPKEQRSGRRRAPEEDSAGYPVIDYDDAPPAYTPQRIDAGVYGSRSTDDRSKDNSGENGTIDYAEFWDRSGNSSEGARNESNRNESNRREAPRRDAEPRNADARNADPRSADSRNGDPRNGAPRNAAPRNADPRGADPRNAGPRSESSRDPDRSSASEWSSWRENTNGWDSGSYGWDTGSQRFNQEDPQVITGAITGDVFDVPYSVGGQALSEPAFGSGNGFGAGAGFGSGNGFGAQQRWDELPDVAPAPEWQSASHRSGPNSTVAEPSAEFELPSLEHLPQAPSGGSDDNSAERRARHASIDEDSGRYKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACW2</accession>
    <name>A0A011ACW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.926"/>
    <dbReference type="HOGENOM" id="CLU_013985_40_0_11"/>
    <dbReference type="OrthoDB" id="1501005at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="212" mass="24000" checksum="F858E7763BA98C1C" modified="2014-06-11" version="1">MTALPGWPATLAEGPVGLRPHRIRDARAWSEVRLANEEWLARWEPTSMRPWADRHRTSDYYELYRSLRRGVRLGQIMPFVVTYEDQFVGQLTLGNIVRGAFCSAYAGYWVDNRVAGRGVIPTALAMAVDFSFAHAALHRIEVNIRPENTSSRRVVEKLGFRQEGFHPRYLHIDGGWRDHVGYALTVEDVAPAGLLARWRTARTGSSSDPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD00</accession>
    <name>A0A011AD00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725659.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.967"/>
    <dbReference type="HOGENOM" id="CLU_017703_1_2_11"/>
    <dbReference type="OrthoDB" id="1555988at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="PTHR10605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="2">
        <location>
            <begin position="46"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="35684" checksum="221097A01214F27B" modified="2014-06-11" version="1">MSMLRHVEVPDPLRAAKRHVPRPVKRAVRRAVRRFGEHTAEQRALPDFLIIGTKRGGTTSVWNWLVRHPNVAPMFPSLQQIKSPHYFDIHYGRGERWYRSHFPSHTALERAAQRSGIRPLTGEASPYYLFHPLAPERVRHTVPKARLIVLLRNPVDRAYSNYWERRGSNAEGLPTFEAAIDAEDERLRGETERILTDPGYYSAHHDWHSYLARGRYAEQLVPWLDRFGRDQLLILPFEDLRSDANGAYRAVQEFLSLPVVEPPRLAHHNKLPVPPMSAATRARLVDYYRPFNARLTELLGTPFDWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADR5</accession>
    <name>A0A011ADR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848997.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1243"/>
    <dbReference type="HOGENOM" id="CLU_040058_3_1_11"/>
    <dbReference type="OrthoDB" id="1884001at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458676" evidence="2">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="218" mass="22223" checksum="8CCC31EB242BDEC2" modified="2014-06-11" version="1">MSVLLTVRRVVTAVALTATGLTGIAFAASPATAACSDVQVVFARGSTEAPGLGILGRPLVSAVQQQLPGLTVDSYAVDYAANVSQTSAGPGATDMSDHITEVAARCPDTEFVIGGYSQGASVTDIAIGIRTTLGRGGTIPENLAPRIKAVTVFGNPLRLSRQTINSASQLYGRKAIDICATGDPVCGNGANAAAHLRYAFDGSVTRAAQFAANLVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEJ7</accession>
    <name>A0A011AEJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849354.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1509"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="46895" checksum="9C0E08593A601C46" modified="2014-06-11" version="1">MTAGPATAQRWAVAVTALAGLLVTLDALVVTTALGAIRAAFDTSAEALEWTVTAYVLTFAVLLMPGTALGDRFGRRRVFVAGLVTFAVASAACALAPTVGALIAARAFQGAGAALVMPLALALLSTAVPPDRRAGALGIFTGVTGVAVPLGPLLGGAVVSGISWAWIFWINVPVVAVLVVLASTRLTESFGPRNRTDPVALLLVAGAALGLVWGLVRGNAAGWTSVEVLSSLVAGVLLVVGFAGWQRRAAEPLVPADVLGSRAFVVGAVAIFLQWGSVLGALFFMAQFLQDGLGFSPLRAGLGLVPWGATTFLVPPIAGHFIGRVGVRPFIVAGLGLHAAAMVWIAVIVDPGLGYGQLIAPLVVSGTGVALALPATQAAALSGVGPGSVGAASGAYSTMRQLGGVFGVAVVVSAFLAAGSYASPRTFATGFAAALAACAALSLVGALTGLVAPRSSAPAARPVVTGRVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEL8</accession>
    <name>A0A011AEL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849387.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1528"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_11"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="477" mass="51221" checksum="C021E26C1043560E" modified="2014-06-11" version="1">MSAGSDFLQLRAEAAPAKGITTWLVDAVRVAVVDGRLGPGARLPATRDLAADLGVSRGVVVEAYRRLVDEGLAEARTGAGTVVTNRLAPLAPPPPGRGPDGVAFDPAGLRLPLGPGEGIEFDLSPGRPDLAAFPRAAWLRAERAVLTSMTSTDLGYGDPRGTLSLRRELAVWLARTRGTRAEPDDILVVAGVAQALALAARVLGARDVAMEDPGSRGARDQITSWGLRPRPVPVDEHGLRVEDLVATGLDTVLLTPAHQFPTGVVLSPARRRELLAWGGLVLEDDYDAEHRYDRAPVAALQASAPDRVVYMGSTSKTLAPGMRLGWMIPPRATRDDLIAVKHSTDLGNPALSQLVLAHLLRSGEYERHLRRVRQRQRRRRDALFAALEQHLPAARVEGVAAGLHLLITLPGEIPDTVLAEQVAEVGVRVHPLSWHRTAPGRPGLVIGYAAHPPNRLEEAARRMGARLGMVVRTDITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJH5</accession>
    <name>A0A011AJH5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ORF">CryarDRAFT_3311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851782.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_2_11"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="19175" checksum="608822CC0712F33F" modified="2014-06-11" version="1">MTDQAQEPRATSSGPPEPVADGAAPKVRDETAELRAQVAQLDERYRRAVADFDNLRKRTARDAHREREDERARVAARWLPVVDNLELALHHATAEPASILSGLEAVRQQALAVLADLGYPLRNDLNERFDPSRHEAVAVLPATDAEPGTILQVVRPGYGTDARPLRPAAVVVAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKK6</accession>
    <name>A0A011AKK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570555.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="29730" checksum="5333B1135AB3CE8F" modified="2014-06-11" version="1">MTATVAAGQLAAPAGRIAENVDRTLRAMRDARSAGVDLLVLPECGLTGYVFDDAASVHAAALEVDGPELARVASAASGSGLHVVVGYLERAGDRVHNTVTLFGPGGPMATYRKTHLPHLGADRYVTPGDNLPVLVTTPFGVIGLSICYDLRFPEWARCLALGGADIIANPTNWPAPAEQVAELFTRVRAAENHVYVIAANRGDEEEGVSFIGRSQILDPSGAVLASADRGDALVIAAIDPAEARRKEILAPEVDFAISLFGDRRPRLYGELTRETPARKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKP3</accession>
    <name>A0A011AKP3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864617.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3703"/>
    <dbReference type="HOGENOM" id="CLU_140387_0_0_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14039" checksum="3EBADE2B7791E099" modified="2014-06-11" version="1">MIHHVQVACPAGSEARLRAFYSGTLGWTELDKPPLLAARGGCWFRVPGLGGPDGELHVGVEADFRPARKAHPAFVVDVDAVAAALAAAHHPVRWADPAEIPGRRRFHTFDPVGNRLEFLGTDPGATGRSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKU8</accession>
    <name>A0A011AKU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852493.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2842421_0_0_11"/>
    <dbReference type="OrthoDB" id="1629615at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="65" mass="7412" checksum="46F4F3A2420E2BFC" modified="2014-06-11" version="1">MLVERITAESERESADPRAVIARMESAEDGGQFGFARYAAEFGLRWYSVQREWVAWVVERMDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL18</accession>
    <name>A0A011AL18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852581.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3818"/>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="31411" checksum="899DC73CC38CB62C" modified="2014-06-11" version="1">MERHARLGEFLQVRRSQLTPDGVGLPDGVRRRRVPGLRREELAMLAGVSVGYYTRLEQGQSQNASVQVLDAIADALQLDAADRTYLHSLATPGHRSAKAEPAPDETVSADLLTLLGAMTGVPAVVLGRRNDVLAWNPLGHALLAGHLDVTGPSRPDERPNMSKIVFLDPHTRDLYVDWDAKARVVAGNLRLAAGRHPHDRDLLALIGELTVASPDFAAMWADHTVQDCASDVYDLRHPLVGALRVQQHTLKLNQTPDQSLVTMTTEPGSPSATALTLLAQAIGEPSRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALN3</accession>
    <name>A0A011ALN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_4037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852817.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4010"/>
    <dbReference type="HOGENOM" id="CLU_000604_70_6_11"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="298"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="332"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="622" mass="65251" checksum="D1AFF0514E4756D2" modified="2014-06-11" version="1">MRWLRVARSPLGLTATVLMVVILALAAFGPLVWGSDADVVDTDQILAPPSAEHWAGTDNLGRDILLRVLVAARLSIVLALLATVLAVVTGALLGAAPFLLGKRSGRIVTAGVNIAVAFPGILLALFFAVVFGVGATGAVLAIGLAGAPSFARLTQTLVAEVEARDYVAAARTVGVGRFRILFRHVLPNIAEPLVVNATIGAGGALLSFAGLSFLGLGVQPPSYDWGRLLFDGIGTLYVNAAAALAPGAAVVVAGLAFNFFGESVAKGLGVPADARLRPLVRKKRVSAPEPDPDVVLDVRDLEVTLAGPSGPVRPVRGVTFQVRRGEAVGIVGESGSGKSMTALAVTKLIADHGQVDAARLEFLGDDLLGPRTALQRRTLGTKLAMVFQDPMTAFNPTRRIGAQLAEVATHHQKMTRKDAMTRAVDRLGAVQIPDPGNRARLYPHEFSGGMRQRAMIGMGLMNTPALIVADEPTTALDVTVQQQVLDLLATIREQDGAALMLISHDVAVIGDVCDRVLVMYAGRIVEELPTGVKPLHPYTRALMDAVPDMATDLGLPLATIPGRPVDPADVPPGCAYAARCPLADDHCRTVDPPLAEHGTAHRVACWHAGEELPATERGEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIG9</accession>
    <name>A0A010YIG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxamine-phosphate oxidase</fullName>
            <ecNumber evidence="8">1.4.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="6">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="7">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="19561" checksum="EDEBEFE934285873" modified="2014-06-11" version="1">MRLAREWLASYDKPPMTLSTFGPDGYPDARTVLLSGVDGGSVQFHTDARSRKAAQLAADPRASAVVLLNGRQIVLVGDVEPLDAPHGAYGLRTRYLQVLAWVNTDELAARPPDVRREAWKRFEEEHPDALEPPPTWAGYRLRPRRMTFWTADDAGPSTRVEYVRHGAGWTARALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ83</accession>
    <name>A0A010YJ83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849069.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1301"/>
    <dbReference type="HOGENOM" id="CLU_059734_1_0_11"/>
    <dbReference type="OrthoDB" id="1262717at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="26934" checksum="9F1CB288961A2C0B" modified="2014-06-11" version="1">MRAISFTTDYGLSDAFVAICHGVALSAAPGVRIIDVTHLVPLADVRRGAAVLADAVPYLPTDAVHVAVVDPGVGTARRAIVVETPRGHLVGPDNGLLLPAAEALGGVVAAVELTEVAPARTFHGRDLFMPAAARLVNGASAASLGPAVRPDTLVALPGAVTRTGPGWLEAEVRAVDGFGSLQLAATAAELDPLGPSVRVLLPDARRHDLARGETFGDVPPGELVVLLDSTGRVAIAVNQGSAAERLAVGAGAVLRLERRRAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKT7</accession>
    <name>A0A010YKT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class putative F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1893"/>
    <dbReference type="HOGENOM" id="CLU_139738_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="14954" checksum="FED3B639513A6F44" modified="2014-06-11" version="1">MSHTDERPASDTFAALAAEPYVSLTTFRRDGTAVPTTVWAAPFGGRLLVWTGAESGKVKRLRNAPVATVAPCDQGGSLLGDPAPAHVRIMRRDEKRTLDAALKAKYGWQFRISALGAAIGRLIGVGRRGQIGLEITLDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKU7</accession>
    <name>A0A010YKU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849960.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1909"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="36141" checksum="AF51368B2C5EE3C5" modified="2014-06-11" version="1">MEFRTLGRSGLYISEIAYGNWITHGSQVEEDAAIACVRTALEQGITTFDTADVYAGTRAETVLAKALDGVRRADYELFTKVYFAVGKGRNARGLSRKHILEGIDGSLRRLNTDYVDLYQAHRYDYETPLEETMLAFADVVRAGKALYIGVSEWRAEEIARAAELARELHVPLISNQPQYSMLWRVIEAEVVPASVEAGLGQICFSPIAQGVLTGKYRPGQPAPSGSRATDEKGGADFVQRWMSEDVLTRVQLLAPLADQAGLTLAQLAVAWVLQNPNVSAAIIGASRPEQVTENVAASGVKLDADLLAAIDAALEPVVERDPALTRSPRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKW7</accession>
    <name>A0A010YKW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1939"/>
    <dbReference type="HOGENOM" id="CLU_483853_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="421"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="519" mass="54316" checksum="AE100A8D762C3870" modified="2014-06-11" version="1">MIVLSLASTGSIAPTLLWCALFALAAAPGLVAPERAWPARIGWLAEVIVVAMAAATPPAEEAFVHPAFVLAYLAAPAFAVGAVAGRAELGALVGVTAVALVVAGALQDQLGSSSYGLAALEWTVLAGVAGVLGLAVQRLVRSRSDAVEPEFVQAARLLTQLRTIARQLPGGLDPGSLGDRLLEELNQVAATDRSAVLTGSGGGRLEVLTQRAPGRVAWETSFDAETPLADTWASQQPQVSNRTLDRAGPGTPVSVLVLPMITGVRTVGLVVLESDRTGAYPPAAVAEAVEVVGNAALRLETALLFDEVRGLATVEERQRLAREIHDGVAQELVMVGYGIDNAIADLPAESEAAESTLRLLRAEVTRVITELRLSLFELRSDVDRHGGLGSAIADYARTIGSSAGLRVHLSLDESTARLPAAVESELLRIAQEAVTNARKHAGAANLWVTCEVDPPFAQVEVSDDGKGLGRDRPEGRYGMTIMAERANRVRAELEIVPRAPKGTTVRVVLGGKSRQGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLQ1</accession>
    <name>A0A010YLQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850352.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2220"/>
    <dbReference type="HOGENOM" id="CLU_083287_4_3_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="15354" checksum="FEA80E4082C32A1D" modified="2014-06-11" version="1">MDDIPLQQVGLAVKRLQWKHHRAMNRRLAPLGVSLVQWDTLRHLQANPGASLHQLAELTFQTDQSMGELAKRMVDRGLIERVAGPGRKVRHRLTPAGDEVRLAGDQVADGVFADSIGKLDAEERATLYELLSKALDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLS0</accession>
    <name>A0A010YLS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850373.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2243"/>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_11"/>
    <dbReference type="OrthoDB" id="1260864at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="26287" checksum="A9DE320FA99FA40F" modified="2014-06-11" version="1">MDINGASAIVTGGASGIGAAAARQLAAKGATVVVADLQAEKGEALAKEIGGVFLTVDVTDTDQIKAAVNAATELGPLRAVVNSAGIGWAQRTVGRDGEFDSAHDLDAFRKVIAINLIGTFDVVRLAATAMSRNEPDADGGRGAIVNLASVAAFDGQIGQASYSASKGGIVGMTLPVARDLAAVGVRLNTIAPGLIDTPIYGEGEASEAFKANLGKNVLFPKRLGVADELASMVVELITNSYMNAEVIRVDGGIRMPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLT9</accession>
    <name>A0A010YLT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850395.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2258"/>
    <dbReference type="HOGENOM" id="CLU_087298_0_0_11"/>
    <dbReference type="OrthoDB" id="1478254at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="16842" checksum="58FBC24A6867E618" modified="2014-06-11" version="1">MLSTPLSGYSGVVQRVVDFLNTLDERTFSRHGEHHVPSDALEPGDAVTLRTALRQALSGGEPDLTAFPLRLTGNLRLTADTGTPWLDPVVESVAVSVATGDWKRLKLCAAPDCRWAFYDTSRNGRGRWCDMEVCGNRHKTRTYRERRQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMY4</accession>
    <name>A0A010YMY4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">htpG</name>
        <name evidence="7" type="ORF">CryarDRAFT_2686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2648"/>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="528"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="602" mass="66793" checksum="772BF38464BE24BA" modified="2014-06-11" version="1">METLEFQAETRQLMQLMIHSIYSNKDIFLRELISNGSDALDKLRIESLVDSDLDVDRSDLHVALTPDADARTLTVSDNGIGMTRDEVVSLIGTIAKSGTAELLRTLREASAESADLIGQFGVGFYSSFMVADRVTLVTRKAGESTGTRWESTGEGTYTIDDVDDAPQGTAVTLHLKPADAEDQLHDYADPAVLTSIVKKYSDFIAWPIRLDGTAINSQKALWARPRSEVTAEEYNEFYKHVSHDWTDPLETIHMKAEGTFEYDALLFLPSRAPFDLYSRDAQRGVQLYVKRVFIMADCEALVPSYLRFVKGVVDAADLSLNVSREILQQDRQIQAVRRRLVRKVLGTIKELPAEKYATFWAEFGRALKEGLIEDAANREIILDLLSFSSTRGSELTTLREYVERRPEGQTEIYYLTGDSRATIENSPHLEAFRAKGYEVLVLTDPVDEVWVDQVTEYDGIPLKSVAKGQVDLGDTAAETPAGFEDFLTWMSGALAESVKEVRLSTRLVDSPACVVGDADDLTPTLEKMFRAMGQPLPSVKRILELNPSHPLVTGLRDAFAAGTQDAEAAELLYGMALLAEGGELADPARFSRLLAERLTKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNW9</accession>
    <name>A0A010YNW9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851329.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370183_0_0_11"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457899" description="Peptidase C51 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="76"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="21721" checksum="47CA9FEB5798BD95" modified="2014-06-11" version="1">MRPTSRSTRFSALLTAVLVGLSVMTAASAARAQAPGDDIRQRIAQAAVSQIGQREQGTNLYPIRYKTSSAVLRPAAWCGIFANWSWRQGGVTLRPNMSGLGVAQGHWATYWQDWGRRNGRWKPIAARRAALGDAVVYGNYPASRHVGIVVGVRYGQDGRVRQVRTVEGNLRDQVTDTRWRDITRLGGGGTVATGFVSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP57</accession>
    <name>A0A010YP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA/RNA helicase, superfamily II, SNF2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3056"/>
    <dbReference type="HOGENOM" id="CLU_025438_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="203"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="498"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="665" mass="72182" checksum="C7A409D48F52E257" modified="2014-06-11" version="1">MIALLAGTAREVEAAAQRGRVTPAVRTKFHAVALLLRDERARLRAEANGAEQLKRLDGIAQILATTAVRDTELMALLAEDAVVSDATRSLKREMLRTVGIEPAPEEAPPPPPVATTPERRVVPQSVVTRQLANPFLAPDFDAYAQRPATRSRRLTSWELISPLLNSFERAGSGDSACMALPAPWELRRTSGKELMAHQARLVAAAADGHRTFLLADEPGLGKTAQALLAAEAADAYPLLVVVPNVVKINWAREAGLWTPHRPATVVQGDGDNIDGFADIVVINYEVLDRHVGWLGNFGFRGMVVDEAHFIKNKTSQRSQHVLQIADRIRSRNPRPLLMALTGTPLINDIDDFRAIWQFLGWIDDSKPLGDLMNALEDTGLTPADPGFYAAARQCVIDQGIVRRRKVDVAADIPGRRVADLPVELDGPAGRSIRAAEKDLARRMVEQYERARTSDGIDPELVRRIAKAELKDAAKTTGENVFSMMRRIGQAKSGLAADYAVQLARSAGKVVFFAKHVDVMDAAEALFEKQGVRFASIRGDQTPRARQKNIDAFVDDPDVAIAVCSLTAAGVGLNLQVASNIVLAELSWTDAEQTQAIDRSHRIGQTEPVTAWRIIAAQTIDARIAELIDSKAGLAARALDGSDEEVVPSADVQLEALVALLTDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPL2</accession>
    <name>A0A010YPL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851724.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_5_1_11"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="23775" checksum="D9E1A0D16B9BE422" modified="2014-06-11" version="1">MAGQLSITPELSEYVRRVSLREDEILRSLREETALLPMGTAMQVPAEEGQFLAFLVGLTGASTVVEVGTFTGYSTLCMARAVRPGGRVITCDISPKWPDIGAPAWKRAGVADRIDLRIGEATRTLAALLTELGPGSVDLVFIDADKAGYARYYEAALALLAPAGLIVVDNTLFFGRVVDPAATDVDTRAIREFNELVRDDPRVELTLLPTADGITLLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPW3</accession>
    <name>A0A010YPW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851882.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3337"/>
    <dbReference type="HOGENOM" id="CLU_080168_4_0_11"/>
    <dbReference type="OrthoDB" id="1857091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="24699" checksum="F02F8CE988A31814" modified="2014-06-11" version="1">MAQPAQLGVPTLAEDLLLLLFQPDSRTIVGENTLFYTLAGAVLADLALGEHVRTGDGRVGSTVVRVVEDHPPADTILRSAWDYVAAKPRGVQTVLAAVGPPLRSQVLERLVLRGELRRETRKTLGLFNRSVLEDGGTGHRARLLDDVRQVLVDGAEPQPRVAALAALISGSGTLPQFDPEIPWSTPVITRAKQLERGNWGAGAAAEAVTRTVTATIINSVIVTATATPQPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ85</accession>
    <name>A0A010YQ85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852068.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3483"/>
    <dbReference type="HOGENOM" id="CLU_1136569_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="26245" checksum="2E0E8984F1238721" modified="2014-06-11" version="1">MTQQMFEDLVGQPPPSTVDVDAIIRDRTRRRRIRQAPMVMAAVAVVAVGATIAGFGHLGTGTTSRDDVVVGKAPAGGTKIRLVVDTAEGKAKSAEELTKAYDEAVKKAVRGAEWKDGKPPRVTDEEAAPPAEFIFGATLIVDGKPGALVIQIENAGEGPDDLATFPLNCDNPDGHCKMTEGPNGEKLVVRRWDYRDGNWQKGDVYTNVTVGLGENRTLNLESHQDLLTEKQISAIVSDLASRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR34</accession>
    <name>A0A010YR34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852587.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3822"/>
    <dbReference type="HOGENOM" id="CLU_069356_36_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20221" checksum="F14A3979C46B5AF3" modified="2014-06-11" version="1">MSESPAGEPARRKQVLRVALGTFARFGYRKTSMEDVARAAEISRPGLYFLFSSKENLFRAAVIDALDDDLAAAASVLADTGRPLRERLIEALDLWAGRYVGPLAGEVTVLVDANPGLLGAVVTEYPRRFVELLTSALADAGAGGVAEDLARTLHSTAAGIKHEVATRAEFVARMTVGVDLMLPALVRTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRQ5</accession>
    <name>A0A010YRQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase-like glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035865296.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4076"/>
    <dbReference type="HOGENOM" id="CLU_004542_9_3_11"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458882" evidence="2">
        <location>
            <begin position="26"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="49"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="4">
        <location>
            <begin position="418"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="632" mass="66949" checksum="CD9FEF1E9FC933A2" modified="2014-06-11" version="1">MRLPVVIVLLAAALTAAPVAGPASAAPPRYLDAGAPVEQRVADLLKRMTLDDKIGQMTQAERAPASADPSMVTKLRLGSVLSGGGSAPTPNTPAAWVETVNTLQKAALATPLKIPLLYGVDAVHGHGHLLGATVFPHNLGLGATRDRGLVRDVYAATAEETAASGVPWNFSPCVCVTRDERWGRTYESFGEDPSLVIEMEGAIDALQENGVLATAKHFAGDGDTEFGTGNGDFTIDQGVTVTSRKDFARVDLAPFVSAVREHRVGAVMPSFSSVDWTEDGVGNPVKMHASKELITGYLKHRLGFDGLVVTDWEGIHQLPDPSVPATAPRPTPLQVRTGVNAGIDLFMEPTSAPRFVTLLKAEVTAGRVPMARIDDAVRRVLRTKFRLGLFEHPYAEAGEVGTAEHRALAREAVAKSQVLLKNTGHALPLRTDSRLYVAGRNADDIGNQAGGWTLDWQGRSGRDTIPGTTILEGIRAVAPDVTYSADASAPIGKDDVGVVVVGETPYAEGFGDVGAPPWPTGTAAQKEKKLLTLQPGDKKVVDKVCAATGTCVVLLVSGRPQVVTDQLPVMDALVASWLPGSEGAGVADVLFGKRPFTGRLPVTWPRTTAQVPINVGDRSYHPLFPYGWGIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRU3</accession>
    <name>A0A010YRU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853015.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4113"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="246"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="489" mass="52501" checksum="FF87ED2480DDC5D0" modified="2014-06-11" version="1">MLVEAAGITKRYGTTVALRDAGLVVRAGATHALVGRNGAGKSTLVSILTGLQAPDTGTVRFSGEPAPALADRDAWRQRVACVYQKSTIIPTLTVAENLFLNRQPGRLIKWPTLRRDAAELLATWDVDVDVTRPAGDLTVEQRQLVEIARALSYDARFIILDEPTAQLDGPAINRLFDRMRGLQERGITFLFISHHLEEIYRVCDEVTVFRDAQHIVTAKVSEVAPTELVAAMTGDATSLTERPSRPPLPEHTPAVLEVRDLDGVSFTVRAGEVVGLAGGGGSGKREIAETVVGLRRAPAGTIEVAGRPLKPGSVPASLAAGVGLVPQDRHTEGFVSDLSIAENLTMTIPRRLGRFGMISRTRRDRVASVLIEDLAVKTPGPELPVSALSGGNQQKVVMGRALANDPKLLVLIQPTAGVDVRSKETLLGVVDRVREGGAGVLVASDELDDLRTCDRVLVLFQGRQVAEFGSDWSDHDLVAAMEGLDLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRU8</accession>
    <name>A0A010YRU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853023.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4118"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34966" checksum="55CEA1E16A7DB68B" modified="2014-06-11" version="1">MQQRSLGTQGLTVSALGYGAMGVSMAYGPSDEQASIATIRRAHELGVTFFDTAELYGWGESEQIVGRAVKDFRDDVVIATKFGYTREFGYDSRPDHIREVADNSLRHLGVDTIDVLYQHRVDPTVPIEDVAGTVKELVDAGKVRYFGLSEAGPRTIRRAHAVQPVSVLQTEYSVFERDVEPLFATLEELGIGFVAYSPLGRGFLTGAVKPASEYDPTDMRNALDPRWQPGNYEKNLEAVQTLRALATSKGVTVAQLALAWLLAQRGYVVPIPGTRSVSRVEENAAAAELELTAEDLAAVRAALPNGSFGARYGRGMVPAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRV3</accession>
    <name>A0A010YRV3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol oxidase</fullName>
            <ecNumber evidence="4">1.8.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide</text>
            <dbReference type="Rhea" id="RHEA:11812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="EC" id="1.8.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organosulfur degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.4" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853029.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4123"/>
    <dbReference type="HOGENOM" id="CLU_032512_0_0_11"/>
    <dbReference type="OrthoDB" id="469959at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018549">
        <property type="term" value="F:methanethiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="PTHR23300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="468" mass="51154" checksum="497BA7780D8B44D7" modified="2014-06-11" version="1">MTQFLDPTFYRSAADAAAAPAEELAYVAVFDRAAEQHDAIAVLDVNPASPEYGRVVGWSEVSGLGDELHHFGWNACSSALKHEGHDMTGLARRNLLVPGLRSSTIYVFDVQADPRDPRLVKTIDAGQLAAKAGYSRPHTLHCGPDGVFLTCLGGPPEDPDGPGGIALLDHATFDVVRAWETDRGPQHFHYDAWWHLNRNVLVSSEWGSPSMIEDGLVPELLLGGKYGHSLHFWDLAEGRHLRSVDLGAEQQMVLEVRPSHDPEATWGFVGVVISTADLSASVWRWFLDGSEWRVEKVITIPAEPADPALLPPLLQPFAAVPPLVTDIDLSVDDKFLYVSCWGTGELKQFDVSDPAHPVETGSVRLGGIAGRTPHPARPDLPLAGGPQMVEVSRDGRRVYFTNSLYGAWDDQFFPDGVGAWMAKLDADPAGGLRVDPAFFPQGEEFRGRRVHQIRLQGGDASSDSYCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV14</accession>
    <name>A0A010YV14_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">CryarDRAFT_0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847342.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.10"/>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_11"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="651" mass="72845" checksum="229BEFC7C5DFC3C9" modified="2014-06-11" version="1">MSEKKKSGYDASSITVLEGLEAVRKRPGMYIGSTGERGLHHMVWEVVDNAVDEALAGYCDTVEVTLLDDGGVRVVDNGRGIPVGMHPVEKRPAVEVVLTVLHAGGKFDGKSYAVSGGLHGVGVSVVNALSHKLEVEIKTEGFVWYQPYENTQPAAKLEKRGSTSEHGTAITFWADPAIFETTVYNLETIRRRMQEMAFLNRGLTLILRDERDPDGDRGDKPREYTYQYKGGIADYVRFLNEKNTPIHKSVIEFAGESQGLAVEVAMQWNESYRESIHSFANTINTHEGGTHDEGFRTSLTSIVNRYAKEKKLLRGSDDNLTGDDIREGLAAIISVKIADPQFEGQTKTKLGNTEVKSFVQKICNEWLNDWFERNPSEARSIIQKASAASRARIAAQQARKLARRKSALDSNAMPGKLSDCQSSDPRECELYIVEGDSAGGSAKQGRDPKFQAILPIRGKILNVEKARIDRVLKNNEVQSLITALGTGIHDEFDIEKLRYHKIVLMADADVDGQHIRTLLLTLLFRFMKPLVELGHVYLAQPPLYKVKWNKKGDDAQYAFSDRERDGLIKLRQEKNPKAKPDDIQRFKGLGEMNYPELWETTMNPATRTLLQVTLDDAATADNLFSVLMGEDVEARRSFIQQNAKDVRFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV70</accession>
    <name>A0A010YV70_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="9" type="ORF">CryarDRAFT_0071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847450.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.66"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_11"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="135"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="418" mass="45451" checksum="DD8F7FF22A78C2C1" modified="2014-06-11" version="1">MIDLRFLRDNPDAVRASQRARGESESLVDELLAADERRRAAVAKADALRGEQKAVSNKVKAASKDERPALVTAARELAATVKAAEAEQAEADAVLREAHLAVPNVVEDGAPAGGEDDYVVIREVGAIPQLENPLDHLAIGEKLGAIDMERGSKVGGSRFFFLTGVGALLELALLNMAVAQAVEYGFTPMITPTLVKPEIMGGTGFLGAHADEIYRLEADDLYLVGTSEVALAGYHSDEIIDLSNGAKRYAGWSTCYRREAGSYGKDTRGIIRVHQFDKVEMFSYTTLDQAHDEHLRLLAWEEEMLAKVEIPYRVIDVAAGDLGSSAARKFDCEAWLPSQNRYLELTSTSNCTDFQSRRLNIRHRGASGRPEPVATLNGTLATTRWIVSILENHQQADGSVKVPAALRPFLGGRDVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVX0</accession>
    <name>A0A010YVX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847795.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.281"/>
    <dbReference type="HOGENOM" id="CLU_028325_1_0_11"/>
    <dbReference type="OrthoDB" id="1786282at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="6">
        <location>
            <begin position="97"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="454" mass="46195" checksum="2F6A930AF4F200D1" modified="2014-06-11" version="1">MSTTSADGLARITLAAPRRRVDLALPEAPPLAELLPTVLRLAGEGLADDGQTHGGWSLRRSDGEPLDPEKPLGTQGIRDGEVLHLVPQRTEWPELDYDDLADAVATGARRQGRAWSPAATRLTGLVFAASLFMFGLVAVLSAGPASAVGVVLLAMAVAFVGIGGLLSRVLSDSVAGAVVSVVGLPYGFVGGAVLAAGSTRMGWLTAEQVLFGSVCLLVVASLGYLAVGDVGFVFVGGFVTGLFGVLGGGLPGTPARGAAAVVVGVALLVVPMLPLVAMRMGRVPLPTLPRSADELMADVSPGPSRRAVYAAVARADDVLTGSLLGVAVVVGVGFLVLTRTRDITAAVLVGVVASAMVLRARLLATIRQRVPLLVAGVVGAGCVTLFVLDESVAPLVFVGVGGVVLAAGVVYSRRPPSPYFGRLAELLDVALVLAVVPLICGVLGLFGYVQSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW32</accession>
    <name>A0A010YW32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.363"/>
    <dbReference type="HOGENOM" id="CLU_1213167_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="23851" checksum="746B347388208D5D" modified="2014-06-11" version="1">MRAVLSALSLLVIGLGFLGFGGWNYYAGTTGEKTTAVVDQCTKSYGRKGRTRTTCYGTWQENGVSKRGQIDGVGDDDQGKSVEVRIHDGEAYAFSWVGVLIPAGVGGFMLVAAVFWAASAFKGGKNQPAAPAWQGPPHPQAARPPQPAYPYAGQPGYPPPGYPPAGYPPAAYPAPGYPQQAYAPPPGYASQPGAYRPAPPPAAGYPPPGYPPAQYPPAQYPPAGYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW47</accession>
    <name>A0A010YW47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.382"/>
    <dbReference type="HOGENOM" id="CLU_017692_0_1_11"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="466" mass="47350" checksum="D11DF68D5555CBC1" modified="2014-06-11" version="1">MRIGRHSVLWLTLCWVLATVLVTDLLWFARGGASEVNSGRDGVLVPAVAAGPVFTDPPAVLTPDDDSAEPPTEAGLTTALSALLTDSRLGSSVAVSVRDAENGTTLFSRNADTPVTPASTTKTVTAAGVLLAYGPAHRLTTKVVKGATEGEIVIVGGGDPTLAFGEKMSYPGSARLDVLAKDVKTALNGAPVTRIVVDGTLFSGPTVGPGWDDDIISGNYSAHVNALTANGARVEPTPDHEGDRTLTPDLFVGQRFAGLLGAGDAEVVQGTAPEGAESVAELQSPPLSHIVDAMLTESDNVIAEAMLRLTAVKKGLPATFDGGTQARKAVLDEAGIDTAGYGLRDGSGLSRLNRLTPNLLTSLLAKAVGTEHPQLRTLLAGLPVASYSGTLADRFGGNSATAGVGIVRAKTGTLSGVSSLAGMTITVEGRILTFAAVANGVPNGGTDSAEAALDQIAATLAKCGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWG2</accession>
    <name>A0A010YWG2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hydrolase, CocE/NonD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848186.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.515"/>
    <dbReference type="HOGENOM" id="CLU_013104_0_0_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="638"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="671"/>
            <end position="678"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="936" mass="97691" checksum="81CA47E7C1D782AF" modified="2014-06-11" version="1">MPGPARSGWRAVVTTRRVVTTLVVIGVLAALVVWIRWPSGEPVRSTDAMVTVRSGPERNEPIELDTTIYVPESATASHPAPAILLAHGFGGSKSSVAADARRLAGQGYVVQTWSARGFGRSGGTISLDSPDYEVNDARALVDRLAERDDVRQDASGDPRVAAIGGSYGGALSLLLAGYDKRVDTIVPRITWNDLANSFFPEATGGGPADGVFKRSWAGLFFGSASGGGVSSVRDLAALLGARPDSNGGIDPSSVDASKVGELAQCGRFEVSLCREYLEVATTGRSTPAIVERLRRSSPSTVLDRIDAPTLLVQGQQDTLFPLSEADANARGIAANGTPVRVAWYAGGHDSTASTRESERVNELELAWLRHYLDGRGPAPSDEFSYTTAGAISARDTRPTSRVYTLGEYPPAEDPYRIRVSGISPQPVANPPDGTPAGVSTLPGFGALTSSFANAGIDVPGQFASYSGVELSRSVDVAGAPTVRVAAASPTGEAVLFLKLYDVDADGRATLPGGAVSAVRLTGLPRTIDTASLVTVTLPMIGHRFESGHSVRLVIATADQAYAGPVAPAVYQVAVQANSLHLPAVTPVPVASSTGTWTWVLIGLLGAVGLGVVAAVVIVRARRRRLDVSVDSEAAGSPLVVRGLRKAYGDGYLAVRDLSFSVEPGQVVGLLGPNGAGKTTTLRMLMGLIRPTGGEILVFGHRIVPGAPVLSRIGAFVEGPGLLPHLSGLENLHRYWQATGRPAESARLEEALEIAGLGAAVHRKVKTYSQGMRQRLAIAQAMLGLPDLLVLDEPTNGLDPPQIAEMRAVLSRYATDGRAVLVSSHLLAEVEQVCSHVVVVSKGTGVAAGPVGEIVGEGRSVLVEVASGDQDAAVAALRAMPGVEVVHPNGAGLVVELAGVERSDVVRELVGAGVGVERLVARRRLEDVFLELVGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWX2</accession>
    <name>A0A010YWX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline dehydrogenase-like flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848434.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.687"/>
    <dbReference type="HOGENOM" id="CLU_002483_2_0_11"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="3">
        <location>
            <begin position="445"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="555" mass="60023" checksum="353A0D9D1773B517" modified="2014-06-11" version="1">MHYDVLVVGSGFGGSVTALRLTEKGYRVGVLEAGRRFDQETLPKTSWDLRRYLWAPQLGCYGPQRIHLLPDVLVMAGAGVGGGSLNYANTLYQPPRAFFDDPQWAGITDWADELEPHYEQARRMLGVTTNPSVTPADVAMRKVADEIGAGDTWRSTPVGVFFGPSGKDPFFGGAGPDRVACTECGSCMTGCRVGAKNTLTQNYLYLAEKAGAEVHPLTTVRSIRTDRPGWTVETVRSGRRSGRRTFTADHVVLAAGTYGTQRLLHAMRKTMPDLSPRLGHQTRTNSEAVLAATSRRLHTNYSRGVAITASFHPDPKTHIEPVRYGPGSNVIGLLQTLLVDGGRGPRWLRALGVAVRNPGAVWRSLSVRRWSERTVIALVMQEHDDSLVVSGKRGLFGGQRLRTKPGPGEPPPRWIPVGHDVVRRLAREVDGDPGGSFADIANIPMTAHFIGGCSMGLSADDGVIDPYHRVHGYPGLSIMDGSTVSANLGVNPALTITALTERACSFWPNRGEDDPRPDLGQAYRRVAPVAPGSPVVPAHAPAALLFPTIKVRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX24</accession>
    <name>A0A010YX24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848473.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.734"/>
    <dbReference type="HOGENOM" id="CLU_065520_0_1_11"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458877" evidence="4">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="26601" checksum="A28346E5D49F2DBE" modified="2014-06-11" version="1">MRRPALLVAVAAAAASLLLAGCGDSSSDTAGSSSSASASADGLKGTVTVFAAASLTESFTTLGKQFEQANPSVTVKFNFGASSALAESIGQGAPADVFASASTKTMDGVSKDGDAVDPKDFARNTMEIAVPPDNPGEVTALADLAKPGLKVALCQEQVPCGATAKKVLDQAEVTVTPKTLGADVKSVLTTVSLGEVDAGIVYKTDVRAAGDKVKGIEIPADQNASTAYPIATLKDAPNADGAKAFVDYVLSADGTKVLEAAGFTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX70</accession>
    <name>A0A010YX70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.776"/>
    <dbReference type="HOGENOM" id="CLU_017290_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="125"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="462" mass="49609" checksum="C914F785891068FC" modified="2014-06-11" version="1">MALSTMSPPAIPTPEELWARAAEELANAGVIGVTIVWADNNGIPRSQIVPIDQLASCSRYGVGLTSLFAVLDSHDGTTFSHQDLSTPSGEVRLVPVIDRLVRLKGQPAFAWAPGRQLGADGLPTPYDQRSVLERQVERAQDAGIAVRAGYELEFYLCKDAELTPAHRGPAYSPTALLRVDEFVAQLLSDLNADGVPVGQLHAEHGQSRLKVTITATDPVSAADRQMLARQTIHAAARAQGLRASFAPVVDVAGIGNVWRLHSSPWRRNKNLLMNGDGPHGLSEEGAGYLAGLLRDLPAIAAVSAPSVPSLTRLRPSAFAGAYAFWGIGNREAPLRFLPSTSMLGPSHANIELTPSDASANPYLALAVVIGAGLAGIEEKLELPEPIQEDVGTWPEERRSSQNIRRLPISTDEQLGALQENPRIAAVLGPELAGAFAAVRRSDHLWAQDRSIEDVIDGHRWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXE8</accession>
    <name>A0A010YXE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569728.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17050" checksum="6D7C9F3B8E353E71" modified="2014-06-11" version="1">MASQEACAQLLDQLPAIGEIKRQFHRVVPAVGTNNVGAAGAIPTLGVLAADGEQRASDLAERLRVDLSVISRQVAALIEAGLIARATDPADRRVHRLAITDAGVETLRVHRAQMVELISRGLEDWSDDDVVRFAGGLRRFADSVADATTRTRLPAAPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXN8</accession>
    <name>A0A010YXN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848733.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1005"/>
    <dbReference type="HOGENOM" id="CLU_074030_0_0_11"/>
    <dbReference type="OrthoDB" id="1395601at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="28994" checksum="5740D869CED81EA4" modified="2014-06-11" version="1">MKSSNPVLSRLADRSAQHATFHRAPAQQPYGGYGAPAGYPQSPEYAQQYAPPTAGRMTVDDVVVRTVAMLAVVGVFGAIGWFVLPDSISVGVAIAAAMVGLVLGLVISFMGLTNPALILTYAAAEGLFLGVISQSFEALYPGIVIQAVIGTFGVFFSMAALYKFKIIRVTPFFAKMVIGALIGVVVLMLANFVASLFIDGGFGLRDGGGIAIIFSLVCICIAALTFALDFKQIEELSAAGADKKYAWLSAFGIVVGLIWLYLEILRLLSYFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY19</accession>
    <name>A0A010YY19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848888.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1147"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_2_11"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20008" checksum="F117FC6E3DDD9336" modified="2014-06-11" version="1">MARALIVVDVQNDFCEGGSLAVTGGAGVATAISAALTADARQWDRVVATRDHHIDPGHHFSDQPDFVDTWPAHTVVGTGGVELHPNFETTRVEAIFDKGEYAAAYSGFEGLSEGKTLTDWLREHDVTEVDVVGIATDHCVRATALDAARNGFATTVLLDLTAGVAAPTTQRALTELEQAGVTLVGEPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYB8</accession>
    <name>A0A010YYB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849009.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1255"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="252"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="402" mass="43676" checksum="F73656DD7884CDD0" modified="2014-06-11" version="1">MFSLDLSEEQDDLREWVHGFAKDVVRPAGHEWDEREETPWPVIQEAAKIGLYGFESLATWWGDESGLSLPIVNEELFWGDAGIAMSIFGTTLAVAGIFASGTPDQLAEWVPQCFGDEADPKLGAFAVSEAEAGSDVSGMKTRARYDEATDEWVINGAKAWITNGGIANVHVVIASVDPSLGSRGQAGFVIPPGTKGLSTARKVKKLGLKASHTADLFLDDVRIPGRCLLGEKEKLDERLARAREGVGSKGQAALRTFEVSRPTVGAQAIGIARAAYEYALEYAKGRETWGRPIIENQAVAFALADMKMEIDAARLLVWRAAWMGRTGKEFGAGEGSMSKLKAGEVAVWATERAVQLLGGAGYSREHPVERMYRDSKIYTIFEGTSEIQRLVIARAISGARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYD0</accession>
    <name>A0A010YYD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849021.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2205689_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11540" checksum="B71B289256B2D57B" modified="2014-06-11" version="1">MLSSEERRQLSAIEAWISADDPAFAAGLAKGRPRAPRRDRRWPLQMVVALATGFALFSLVAGKPLGLVLGAVIACAAAVADQMRARRRHGSTSAVGRPNRRDGFQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z010</accession>
    <name>A0A010Z010_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154923_0_0_11"/>
    <dbReference type="OrthoDB" id="1714635at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="240" mass="25468" checksum="98BB2DB5A1C0BBE1" modified="2014-06-11" version="1">MGRYVKKRGDDAETQYWYPGEKVDWMQGAIAIGGGVIAGVAIRLVTDSTMWGAAVGFSVTAGLAGMYLGRRDARALAVTDTTRLSGLVLIGMAFLRALAKGSGAALAAIVISRAATPGIWTEWLLPLVPAVIGAVAHHLGMFYENLEKASQVQVKASESELAKFAAEMRKAKETQAAAPPVETPTEALPPVPERQDIPAASLPGEVDDKPRWPQRAGTESTGFHSESGAVFSRRRPADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0J3</accession>
    <name>A0A010Z0J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall-associated hydrolase, invasion-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850113.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2033"/>
    <dbReference type="HOGENOM" id="CLU_063612_0_0_11"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="66"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="348" mass="35376" checksum="CBC9B77B480827EE" modified="2014-06-11" version="1">MLAIQSQIAQTATRFGAGVGQPSGFAGALSAAQTSASEATEATAATGGTAGSSTVDRVGNALSPGGPTGADVVTAARKYLGVPYVFGGTDPAKGLDCSGLVQRVFRDLGVEVPRLVRHQRLEGSPVASLSQAKPGDLLVFDGYEHIGIYLGKGKMLHAPEPGEQVKIGPVYETPTSIRRVLPAEELQTSALNAAGSLLRNAALGSAASAGGAGSGGVLAGVPFADLFTSAGTRRGISPALLAAVAKIESNYDPDAVSRAGARGLMQIMPATARELGVDPFDARQAVDGAARLLKQHLNEFGSLPLALAAYNAGGGAVRRYDGIPPYAETQQYVVKVQNALRALGKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0Q2</accession>
    <name>A0A010Z0Q2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570001.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962133_0_0_11"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="29964" checksum="D0D496482C727F7A" modified="2014-06-11" version="1">MTEMQCRELVGAYAVGALEPPEAARLADHLLSCTRCRHELDEAEETAAIMAAVPPEAFIDEPADPNDAIFMRALHDIRLEAFEQSGPPPRQEAGPQLRSVPGGRQDSFPGYSGQKARSHRRRPRAGSASQQRRTLAFAGAAAAAVLVLGGGVLIGSGLGDSDDGGTKTAPVAKQTQATSQAADPGIGSANLPGLEGENTTTKAKLTVDVSSADTGYLSLNLDGSNLPAGQDVEIVVSDTVNNDTVVDTVKVSAAGVLDETKPVKMAPTELTTVTLRTAAGEILVTAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1G5</accession>
    <name>A0A010Z1G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850498.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2316"/>
    <dbReference type="HOGENOM" id="CLU_112790_1_1_11"/>
    <dbReference type="OrthoDB" id="1650155at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="PTHR31757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="17456" checksum="96E104C241AEB0AB" modified="2014-06-11" version="1">MRPPLPPFTAETAATKVQAAEDAWNTRDPERVSLAYTEDSVWRNRDTFLTGRAAIVEFLTAKWERELDYALRKSLWAFAGNRIAVRFQYECRDSSGQWWRSYGNENWEFDEQGLMRRREASINDLRITEDERRIIGPRAPGDESELPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2D6</accession>
    <name>A0A010Z2D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570123.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2667"/>
    <dbReference type="HOGENOM" id="CLU_083287_27_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="18739" checksum="90D9B8AC057B48F0" modified="2014-06-11" version="1">MSKSAPGPDHVDRILAQWHRERPDLDVSPMAVIGRLSRAAAAVHGRLDRTFAAHDLDRGSFDVLATLLRNGPPHRLTPAQLAADAMITSAAVAQRLNRLESRGLITRAPNPDDGRGSLVSLTPSGKAAVEATLPAHLATEQELLAGLSPEERETLAALLSRVSHAADPKRQAPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4U4</accession>
    <name>A0A010Z4U4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852103.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068242_0_0_11"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="131"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="28302" checksum="B5A8C408F43B9C01" modified="2014-06-11" version="1">MRHWGAIAETAEAESLYALASGTSPADRETFGIAATRLGGGVVVSTPEDPTGFWTKVLGLGVTEPVTAGVVDAAVDFLTAHGSTRATFQIAPDRLPDDWDDIAARHGINAGSSWVKLACPMAAFRPGETGLRVRPVTDADADRAAAVIAAGFGMDPTLVAGLYAPAWRSGEFLGFAAWDDDEMVAAAATRLAPPTASMYGAATLPGHRGHGAQSALLAARAAVAETAGCEVLVAETYVPPVEGTNPSLNNMIRAGFEVLYVRVNQVWVNRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4Y9</accession>
    <name>A0A010Z4Y9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-nitropropane dioxygenase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570502.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3557"/>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_11"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="2">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="38793" checksum="E606D3D8FAAD08BF" modified="2014-06-11" version="1">MTATRFSTPLTELTGVEHPIVQTGMGWVAGPRLVSATAEAGALGLLASATMSIDQLEKAILEVQERTDRPFGVNLRADASDAGARVDLLIRYGVKVASFALAPKPELIARLKEHDVVVMPSVGAAKHARKVASWGADLVLVQGGEGGGHTGPVPTTLLLPSVLDAVDIPVIAAGGFFDGRGLAAALSYGAAGIGMGTRFLLTSDSAVPDAIKQKYLEFGLTGTVVTTKADGMPHRLLRTPFIEALESGNRVRRAASTVRRALAYKRMSGASWRSLVSDGWSMTRGSDRSWTQTMQAANTPMLLKAGLVDGDTSAGMLASGQAVGVIDDLPSCEELVARIVADAVTHLTAAHAALVPPTPAGAEPGAEPGPPPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5H0</accession>
    <name>A0A010Z5H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852504.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3754"/>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="193"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="39873" checksum="3B15CEB184FC82CA" modified="2014-06-11" version="1">MRIAHVTDVYLPRLGGVELQVHDLALRQRSAGHDTVVITTTAPPPGLEPSGRVTDRLADVEVLRLGHGRIGAGPYRGVSDDELVATLAALGIDAVHVHLSTFSPLAWAAARLAGRTGLPTVVSVHSMWHDIAPLVRGYARRRHANRWPVAWAAVSSVAAAGVRDALDGAPVDVLPNGIDPGAWLQPGAPDPTRVPTVISVGRMVRRKQPRPLLRTLLALRATRPGAFTAVLVGDGPLLPALRREVDRAGAADDIVLTGALDRTAIRARLAAADLYLAPAHRESFGIAALEARSAGLPVIARTGSGVADFIRDGVDGWLVGSEADLLATVGALLDAPDRIAAIGRHNRAVPPAVNWDAVLNRASALYDRAAGHQGRVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z698</accession>
    <name>A0A010Z698_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852785.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3992"/>
    <dbReference type="HOGENOM" id="CLU_047583_0_0_11"/>
    <dbReference type="OrthoDB" id="938410at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="40002" checksum="5F6EB57A5105804B" modified="2014-06-11" version="1">MTDIEPVLEQTRGFRWGEVPADRHRRRAAVEIADPDLGGIAGFRGTFRGTGLNTIFRPQNFGATPTPLLNPASGPDDNVLEINLTEETLSFSQPLGSIPNRGMVQGDIFLNGIPYLQSINDVTDPGQAVGIHFEPGIWLSVPATTVPALPPTVARMASIPHGTTIEAQGTTFTVAGGPTIAPVDITPFPVGSPGTPIKFPSQTAAATDTFRIPQDLSPFIAAGTITQEILDNPNVVLTKRADAQTITSTTVIVVSTDPASPVFGGGADNIAFLKGDTAGRNPNADAVTMSSIFWVETVTETITVRPPGAGFPVIVRGSGPDPAPSFRVNSAAPITRETTVEVSYVQIQYTQTVLLNFNGLSWPHVSVATLVPAEPVPVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6E8</accession>
    <name>A0A010Z6E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852895.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4049"/>
    <dbReference type="HOGENOM" id="CLU_828681_0_0_11"/>
    <dbReference type="OrthoDB" id="1563802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="34299" checksum="5ADB283E5F17A264" modified="2014-06-11" version="1">MRAEGPYFDELSVGQEFAGAPAYTLTSGRAAAHQAILGDRLRLPLDSGLADAVAGRGALAHPAFVWDVAIGQSTVVTHHVRANLFYRNLALHRLPALGDTLHTVTTVAGLRQNTRREGRPPTGLAALRIVTVDQEGRSVLDFYRCAMLLLRSDADTGHRDDLDALEVAPAADAGRGGVAGWDLDAWRERVPAGPDREVGSRIEVIGGDVVTSAPELARLTLNVARVHHDADAGGGRRLVYGGHTIGLALSQVGRALPELVTVVGWDSCDHVGPVHEGDTLHSVVTVEGIVPAWAGGSLVTLRSEVADSTGRPVLDWRFRALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL17</accession>
    <name>A0A010ZL17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847896.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672157_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="409" mass="42525" checksum="B0FE5374F8D55803" modified="2014-06-11" version="1">MSTNVAHVEKTSFSAHASANVLRLANSDAGPHATALNGLRLGTSTASVDTDQSTASATQLIGPPGAPLTAATRRAGDNDEESGTVTRSNSGVELPFLTLGASRLTATANWGRPDSPIALSSALARPGELVLRPEDDEALMQVWRGSQTRTQTQLVAVAGQSTLGLRTTAKAELSAVTLFRGTATEMTIRFLRAPSLMAVAAGTERTDVRYVPPVVAVTASQGRSYRLDEAGESIEVPLDGPGCCNRVVRVRLGTVRERVGHTSVDATAAAVRLQIIGAEDRLLDATIGDLDVSAHVPNGGLGQSAHVPIGGQGETRTPCRPCDTDEPVETDEPVVEPQEEIVIPGALTPREDIASEAASPQPIAPSPSEAATPQEALPRTGASLPLIAAIGLALLIVGWIVVRAVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMG9</accession>
    <name>A0A010ZMG9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134413_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043993">
        <property type="entry name" value="T4SS_pilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18895">
        <property type="entry name" value="T4SS_pilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="141" mass="14991" checksum="4196A9A07A773E9F" modified="2014-06-11" version="1">MRDPKFHPRGRHRRPRPTLSNRSVRWRLLAAVAVTMTMAVLVVVALGGAALGAQTPAPVNAPTTSTKDLDDVINRLWALLTGLLVGYAGLMIAWGAVRRIGADGEPGEIERANRTMRGAVIGLALGILAPLLVAVVAKVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN07</accession>
    <name>A0A010ZN07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848858.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458236" evidence="1">
        <location>
            <begin position="35"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="426" mass="45978" checksum="E025526C15EC8F49" modified="2014-06-11" version="1">MGATGRTRWIARLAGATALALGLAACSGGTGASDADNSGGGDSAKEIKVVIAEYSKDHTATFWNAFKKTYEDKTGVKLNLQIISWNDIDQQASTMVQNGNPPDILNLNAYASYAKDNLLYNSDEVLTDSVKSDMIDAFVKSGTYNGKFYGMPDLSSARALFYNKDLFAKAGIAAPPKTWAEFVTDAKKVQALGGGNIGYAQPLGPEEAQAEYSIWLFNNGGDWKSDGKWTINSAKNVETLQFLKDLSVKDKVTQNNPGKTNRTDGAFPLFTSGKAGMIVGFGPLQGDLDSKYKNVKYGIAPMPTKDGSAPQTYGVTDYLMSFKKSGNQDAVKKFYELYYAKDQVNTWIKSEGFLPVTKSGLEEFSSEASLKVYLDTLPNIHLTPTDDPAWDKIKLAVQQNLGTAVSPSGDPKAVLDDLQKTAENGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNQ2</accession>
    <name>A0A010ZNQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591775_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="167" mass="17483" checksum="D3376E0B3B1471A1" modified="2014-06-11" version="1">MTVARVMVARVMVARVTVVLVTVARVTLVLGKGSRVMGGRSSRASVRSGVTVVTRGGVRRSAARQVRIRVSRGFGRSGGTMPGVEGPGVSLALGRTSSEASRTSSPTVDVPVEGVTRVILVTCVILVSRATSRRCRIRGSAGTAMCCRSSGRPESCRGWAGRSALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPD9</accession>
    <name>A0A010ZPD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849479.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1599"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="26664" checksum="37B6F29172AC8C0B" modified="2014-06-11" version="1">MSLRAESVSWAAGGRLIVDAVDLDAAPGSTVGLLGPNGSGKSTLLRVLAGLRRPSAGVVTLDDAPLSSLGRRGLARRLAVVEQHAVTDVDLTVRDVIALGRVPHRRGLSAPSAADSAAVLTAAARTGLTTHLDQEWRTLSGGERQRAQIARALAQEPRELLLDEPTNHLDIGHQLELLALVCALPVTSVVALHDLNLAAMFCDSVVLLHRGRAVAAGTPAQVLTRETIREVYGVSALVSTGADGRPTIHFARPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPI6</accession>
    <name>A0A010ZPI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1650"/>
    <dbReference type="HOGENOM" id="CLU_055261_9_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="15330" checksum="01D4D04C77C047ED" modified="2014-06-11" version="1">MAVRLTAGQAGDNPQLLPLLDEISVHRPGPGRPRKRPDRVVADKAYSHPSTRAALRRRKIAVTIPERRDQVARRAAKGSAGGRPPAFDPVIYRQRNLVERCFNRLKQFRAIATRYAKRAVLYRALLTLAATLIWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPS2</accession>
    <name>A0A010ZPS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma subunit, ECF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849679.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1729"/>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_11"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="406" mass="43920" checksum="831AABF29F9BF63D" modified="2014-06-11" version="1">MTADAVERAFREEWGQIVATLIRVTGDWELAQEAAQDAFAQALARWPAEGVPRNPGAWLTTTARNRAIDRLRREAVGATKLRELAREPVDEPAGYDVADDRLRLMFTCCHPALALDARVALTLRTLAGLSVPEIARAFLTSEAALAKRLVRARQKIKHAGIPYRVPPAHLLPSRTPAVLAVLYLLFTEGYAATAGTELVRRPLTGEAIRLARLLRDLMPDEPEAAGLLALMLFHDSRSSARVDADGELVPLDEQDRSTWDAAGIAEAERLLETAGGSGPYVIQAAIAACHATAPTAADTDWRQIAVLYGALREQVPSPVVALNQAVAVGMAYGPRVGLALLDDLGDALADYPLHPAVRADFLRRLGRTTEAADAYREAIRKAATEPERKFLRRRLSSVGGGRSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPU5</accession>
    <name>A0A010ZPU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1755"/>
    <dbReference type="HOGENOM" id="CLU_137417_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13022" checksum="BD9795E3A0823BCC" modified="2014-06-11" version="1">MRARNGGDMTTAATPEDLARLFVERCNANDADGIAALYEPDAVLGYPAGSTTVGRDAIRALFEKAAPMMPEMTVEEPRPTLYFGDLALTATRPADGTGGRAQVARRQPDGTWLRILDRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQK3</accession>
    <name>A0A010ZQK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848198.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_0_11"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="68" mass="7374" checksum="D22741F03114CE92" modified="2014-06-11" version="1">MAQGTVKWFNSEKGYGFIAVDGGADVFVHYSAIMMDGYKSLEDGQRVDFEVTQGPKGPQAERVTVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQK9</accession>
    <name>A0A010ZQK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular protease, PfpI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.524"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="18877" checksum="0B8D9D0492055620" modified="2014-06-11" version="1">MATQLNGARIAFLATDGVEQAELDQPWAAISDSGGQPELISLSGGKIQAFNHLDHGDTRSVDRDLDAANPDDYAALVLPGGVANGDFVRADERAVSFVKSFFTSGKPVGVICHGGWVLIEAGVVEGRTLTSWPSLQTDFRNAGAEWVDREVVVDGKLVTSRKPDDLPAFSAAVLEQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR14</accession>
    <name>A0A010ZR14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.679"/>
    <dbReference type="HOGENOM" id="CLU_2715603_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459159" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="72" mass="7317" checksum="B365717F472411E9" modified="2014-06-11" version="1">MTAATLPPSLRVLGRRRERTTRLAVAAALLAALATFSLTASGGSTTAPSAAPVLAAVSRTVTTDLLPRGDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRL9</accession>
    <name>A0A010ZRL9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850517.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2327"/>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="366" mass="38656" checksum="47C8B4C8EDF71BC0" modified="2014-06-11" version="1">MHIAIVGAGLGGLTLARVLHVNGIDATIYELEASAEARTQGGMLDIHEEDGQRALRDAGLHERFRARVHGGGEATRVLDRHNTVRLDEPDDGQGGRPEIDRGHLRRLLLDSLPEGTIRWGSKLVGAAPLGDGRHELTFADGSTVVSDLLVGADGAWSRIRPLVSAAAPAYTGISFAEVDLLDADRRHPGPAAVVGGGMLFALGPDRGFLAHREADGSLHVYVALRKPADWIRGADRAALLDEFAGWAPELRTLIAEADGPITPRTIHALPIGHRWDRVPGVTLIGDAAHLMSPFAGAGANLAMFDGSELARAIVANPGDVEAALAAYEEPMFVRSAEIAAEAAGTLEICFRADAPQGLLDLFAGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRP4</accession>
    <name>A0A010ZRP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2362"/>
    <dbReference type="HOGENOM" id="CLU_069356_23_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20611" checksum="2DECB035B2AD5D16" modified="2014-06-11" version="1">MPSIPLELPGALAPAPGGRPRDRVLATASVLFYTVGIRAVGIDRIIAEAGVAKATFYHHFPTKDALVCAYLADLHDRQAAAFAALASSVGPVDAVLVMFDALGEFTCGPGFRGCAFVNAAVEYPDPASPVRAVVADHRRWYADAVRDVLVAAEHPRPAETARMLVMLRDGVVIGGQVDDPAAVRATLRAAVTALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRR7</accession>
    <name>A0A010ZRR7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ORF">CryarDRAFT_0969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569748.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.953"/>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_11"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="212"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="31797" checksum="0F7064FAEA655B68" modified="2014-06-11" version="1">MEEYPLTVPSRSAVRVRVPAKINLHLGVGPLRDDNFHDLATVFHAVSLYDELTLECGPPGVRLVLQTPDDDVPTDERNLAVRALTVLAEYANIEPAVTVRLRKGIPVAGGMAGGSADAAAALIAGDALWQLATPREKLHELAARLGSDVPFALLGGDALGTGRGERLTPLTHPYQRHWVFVTAAEGLSTPAVYAESDRIRGPVEASDPEPVIKALDEPDPQALADALCNDLQAATLALRPELHDVIAAGEAAGALKGIISGSGPTCAFLVRDAAHAQQVAERLNYPTKTAHGSVDGAQLVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS30</accession>
    <name>A0A010ZS30_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848777.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2463885_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="88" mass="9647" checksum="9E8796C017228650" modified="2014-06-11" version="1">MAKTMRVRMAGKIVGDRCDNGVWSTWPEPGEEIELPEAEARSMLLSGMAVHLDGTSGQQTQRNDYSGVFVPGPDGVPVRSPYMSQEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSP6</accession>
    <name>A0A010ZSP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose:LPS heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570167.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2800"/>
    <dbReference type="HOGENOM" id="CLU_038371_0_3_11"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="35966" checksum="5A486EC30CA3F169" modified="2014-06-11" version="1">MRTLVVRLDSAGDVLLAGPAVRAAAASSSHVTLLCGPHGAAAARLLPGVDQVIVWDAPWVGLEPPPVRPAGIETIVETLAVEYLDRALILTSFHQSPLPTALVLRLAGIGWIGADSVDYPGSLLDLRHRRAPHRHEADAALDLAVDAGYALRADDPGGLAVLPPPDVRALVGDEPYVVVHPGAAVPARAPSPDTAIEITAALRERHRVLLTGGPDETALTAAIARRTGAEDLGGRTGLHGLAGILAGAGVAVVGNTGPAHLAAAVGTPVVSLFAPVVPAERWAPYGVPSVLLGDQHAPCADTRARTCPVPGHPCLSSIRGADVRAAVDSLLRRVKQRPTVPLTNREVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSV3</accession>
    <name>A0A010ZSV3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative threonine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569843.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087840_1_1_11"/>
    <dbReference type="OrthoDB" id="1953934at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="208" mass="21174" checksum="549D1BE25CEABDCD" modified="2014-06-11" version="1">MFTAALAGLGLGLFVAAQVGPVSLLCVRTVLRHGLAPGLAVGLGAALVDVFYAFLGMLGVAQLIRSDVVRWSLGFVGALVLVWMGARTLWTAHRVRLGLETSGEVASVAAALRTSVLATASNPLTIVSWASIFAAASTAALMSSFGAAASLLTGVGLGSVGWFTGLAFVVFLARQRVGTRLLQAVDSIAGAGLVAFGGLLAFRTVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT08</accession>
    <name>A0A010ZT08_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679053_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="41932" checksum="FE477200DCBCB7B1" modified="2014-06-11" version="1">MHTTRGSLGAMSAIHPIPVGWVSTGGTGAQNYDEFADDAEITALVAGNPDSMLGVEMPHRTPEAVADGLDFAAALPTAVARLRGLVDREKFTPFTESIAVYRIGESFLGMFCLVDTAEIGGGRVIRNEEVFAAKVAERTALIRALGVLTSPVLLVQASDSLRSALSALTLGEPAVSDTDRHGQTHSVWLVGPGADQDRLLAAADVGELVVADGNHRSLAAQEAGLSRFLAVVAPASSASIRPYQRLLRRLSMPVAGVLDGLRSVGCGVDAVDAPPATPRRGTVVLYAEGRTYEVKLPSVAGGTVDRIDHTVVEQLLVRQVLGLTPDDPAISYVGGDYPASWLAAEVDAGRAALAVLLAPVTVEDFVAVNLERATMPRKSTWFTPKARTGLVLADLEMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT20</accession>
    <name>A0A010ZT20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851284.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2916"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_11"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="29625" checksum="CB96425A2739AC9C" modified="2014-06-11" version="1">MFVITGATGQLGSRIVERLLRQVPAERVAVSVREPAKAGALAERGVRVRGADFTDPASLRDAFEGAEQVLVVSAAIRGADEAVAANTAALDAAKAAGAKRILYTSHQAASRDSLFGAAQTHARTEEHLAGLGVPFTALRNGYYATAIGLTLGGVRETGRLALPADGPFSWTWHDDLADVAVAALTTDGLFDGATPPLTAPEALDFEGVAAVVGEVLGRTVTRVVVSDEEWAAASGLPPAAAEFMLGMFRAARRGEFAVTDPTLETVLGRPATRVRTVLERLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT39</accession>
    <name>A0A010ZT39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849232.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1424"/>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_11"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="56"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="309"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="453" mass="46806" checksum="1A19A9B0F78FAB53" modified="2014-06-11" version="1">MSDNNRAAEDAAELARAEAGLNARGPGRMVPDRDRIVALLDLLGNPQRAYPSIHLTGTNGKTSTARMVDSLLKSFGLRAGRYTSPHLESVTERISLDGTPIPAGKFAAAYDEVAPMADLLDAKNADPVTYFEFTTAMAFAAFADAPVDVAVVEVGLGGQWDATNVLDAGVAVITPISLDHAALLGGTVASIATEKAGIIHGDASVITAVQPAEAIEPLLARAASEGASVAREGVEFGVLERTIAVGGQQLRLKGLAGEYGEIFLPLHGAHQAQNAVLALAAVEAFLGAAPGRALAADAVREGFANVRSPGRLERLRTSPTVLVDAAHNPAGMTATVQAMAEAFAFRKLVAVVAVLDDKDYRGMLELLEPVADAIVVTENSSPRRLSVDELAAAAVEVFGADRVDVASRLDDAIESAVTIAEEDDDGDAPLAGAGVLVTGSVVTAADARKLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT56</accession>
    <name>A0A010ZT56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634269_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458271" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="180"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="470" mass="49323" checksum="3DC89C7A7FC581F7" modified="2014-06-11" version="1">MRGRQWGVAVLLGALVINGGGVAVAAEESSGGRSPAADARLAAALQKAVDGQKFAEVLDTVPPSTSAAKELYRTELAPDDKGRSAASAKLAAAAAPIHQTPQLDATVIKLDRAGRPIAAADVILSPQYPNGKIIPLDANLTTDQVRWRQWDDATWDNGARGTVDIVPGRENAPVDFMSPYPASVLKLMVGFGILRMVDAGELSLDDTYTYTPVGTPSSLCGGARAATSITQLFDEMITVSSNPSTCALIKLMHERGKIDGLNQQFVDLGLPTLRVKGTNPNTGGTWANAVTMSSIDTAKLLLLFNGSPGTLWKTPSGTPVNASVLSASSRSYLLGKLGEQGLNQVLSTTNYCGRAYPPPGIPQVTPSRWIDPATGVVSVAGRNYGQDVRPCNAAATVTFAHKTGLADTSGNDAGIVKSLPGKPFRSYIVSVHSNLGYRYVDADRPADPAGVYPVQYTEKLALLGRAINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT61</accession>
    <name>A0A010ZT61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2964"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="28132" checksum="F46D2CF9D2066529" modified="2014-06-11" version="1">MLVGVTGAGGALGRAVVRRLAGRVPVVALTRHPERRAAAEGLLVREADFDRPRTLAAAFAGLDRLLVISTDARSNDTRTAQHAAALDAAAAAGVGHVVYTSLVGAGGPPEFLNAAHTATEARLKADFATWTILRNNLYLDGLDAAAPGGVYVTNSGSGAVAYVTREDCAAAAAEVLAAPDDRYAGRVLEVNGPAALDANGVAALLSERTGAPVTARVLEDDDYRAHLTGAGLPEGMITALITLGRAIRAGRYASTRPWAQATPPATARSRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT76</accession>
    <name>A0A010ZT76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComEA-like protein with helix-hairpin-helix repeat region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="245" mass="25116" checksum="A99574EC59580AA7" modified="2014-06-11" version="1">MGRREVVRDASIARSRVEVLFDDPVSAVPLPGEELGSAGGWRRWMPESVRGAAFGPGRRGVWTLAVVALVVALVAGIAAWRARPDAEPVDTATIVDAPSRSGVASASPSTAVVAVSGRVRRPGLVRLPAGARVADAVNAAGGALPGTDLSALNLARKVLDGELIAVGVPGAAPDAPTAGGSGSPLDLNAATVEDFDGLPGVGPVLAERIVAYRTEHGGFRSVDQLREVDGIGDSRFEKLRSLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTA7</accession>
    <name>A0A010ZTA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851450.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3023"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="32656" checksum="CA03D402B924D33E" modified="2014-06-11" version="1">MDPVTEVLRLSGLKGTVGTRIEAGSRWSAEVSGHPGIATHAVLSGGASLVTDDGRHVDLAAGDVVMLPIGAKHRLGDDPGGEPVPIPARGGAGQCLRLGSGPPRTRIFTVYYDCNHVTRTQVLDELPDFLHVEGGEPGAAYLDDVVRLLGRELSHPQLATTAVVDSLVDLILIQLVRAWLARQPEHRRGGWLGWADDPIVRDAVERVHADPAGDWSAATLAAALNVSRATLARRFQAAMGRSPAAYVTQWRMDLAASRLRDTRDPVEAVAARVGYRSVPSFTRAFLRDRGTTPGAFRRQRQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTB7</accession>
    <name>A0A010ZTB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3033"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="457" mass="48859" checksum="5061C2028A631013" modified="2014-06-11" version="1">MPELLLDLGGARSRAALEHRVRDAIRGGRLRAGVALPPSRVLARDLGLARNTVADAYAQLVAEGWLVARQGAGTWVAAGTPGATRRPAETPAEPATRFDLRPGRPDVASFPRTAWAAAGRTALRRAPSEAFDYPDPRGRPELRAALAHYLGRVRQVDVDVEHLVVVSGYTQAVALVAEIVGGGSIVLEDHGFGHHRWIVERSGATVHFAAAGRPDEAPDADAVFVTPAHQFPLGVALAPERRLALLERVRRTGGFVVEDDYDGEFRYDRKPVGALQGLDPARVVYVGTASKSLAPAVGLAWMAVPDALLDRVVEAKTAADRFTGALEQLTLAEFLTSGGYERHVRRSRLRYRRRRDHLLAALTPLPGLRVSGIAAGLHALVEFTDGRTADDEPALVAAAAAHGVRVQGLGELRHVAGTYPAALVLGYGTPPDHDYRAAVDAVVSVLATRRPARSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTD6</accession>
    <name>A0A010ZTD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849398.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1534"/>
    <dbReference type="HOGENOM" id="CLU_023194_17_0_11"/>
    <dbReference type="OrthoDB" id="1339160at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="40876" checksum="B7D089FA421E04A7" modified="2014-06-11" version="1">MSKAELGVGMVGYAFMGAVHSQAWRTVNHVFDLPVGVRLAAIAGRDPVAVKSAAEQHGWAASETDWQALIARDDVQIVDICTPGDTHAAIAIAALAAGKHVICEKPLANSVSEAADMAAAAADAAARGVRSMVAFNYRRVPALAYARSLVAAGRIGTLHHVRAAYQQDWLVDPSAPLTWRMQKERAGSGALGDIAAHIVDAAQFVVGDVLSGVSGLLETFVSSRPLSGGSGLSAASGGAGVGDVTVDDAAVFFGRFAQGGIATFEATRFATGRKNAMQLEIYGSDGGIRFDFERMNELLFFDGSSPDEENGFRRVLVTEPTHPYLGAWWPPGHPLGYEHTFTHELRDFVLAIGSDSDPSPSFADGLQVQKVLEAVSLSASRGSGWVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTE5</accession>
    <name>A0A010ZTE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849411.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1548"/>
    <dbReference type="HOGENOM" id="CLU_034180_13_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="41569" checksum="126B1F5E47804A18" modified="2014-06-11" version="1">MDWPGFGGFFVARTVSWAGSALTLVALPVLLYERTGNAALTGLATALEALPYLLLGLPAGALADRWDRRRTLVVTALLSGLLLASVPVADAWGALTPAHVLVVAGGVATLFVFSDAATFGVLPTLVGRDRIAGATGRLNTANTIVTVAGPAVGGLSMAVLGPAWTLGLDAASFAVAAVLLHRLVLPPVTVPEGPRRMRAEIAEGLRFLWNHQAIRWLTLLGVGNSLTGGAVLGLVVVAAVRNLDLGESDGRIGLLYAAAGAGSLLAGMLLPPIRGRLTVGRITLAGLLAGWVAVSAWALSTGLVGGLVALAAWQAAHVLVNLNGIVLRQESTPDALQGRVNTTARMIAWGGQPLGAALGGVLAEVFDVRAALLIAGAGVATSALVGAGGRLWRLDVRTPRPEPVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTS5</accession>
    <name>A0A010ZTS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570328.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3200"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_0_11"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="931" mass="100509" checksum="EEC4F6675DB606AA" modified="2014-06-11" version="1">MLRFTILGPVGVRRGDLELEAGGRQQRVVLALLLARAGSNVSVSELIDALWEEDPPTSAVNVVHRHIGMLRRVIEPDLPVRMVGNYIIRTAAGYRLRADIESLDLLRFRALADQARDATAPGRAIRLYTEALTLWQGPSAAGLESMSGVHPVCVAIDAECSLVVREAADVALRDGPVGLVIPALRRAAQLSPLDEALQARLILLLAADGRQSEAVDLFRTVRRRLDEELGVEPSRELFDAYERLLHQRTTPSTRPARPVPMPAGPQPVPAQLPADHPFFSGRGEVLARAEALLAEDRRHNRPTVALAIDGMPGVGKTTVAVHLGHRLALDYPDGQLYADLRGFADEGAAMAPAEALQGFLSSLGVPLSDIPTELHALAGLYRSMLAGRSVLIVLDNCRDYEQLRHLLPAAPKSLVIVTSRTRLTGLIAGGGGQPLPLDLPSRAEAQAFVARRLGHERVAAEPAAVDEIVDRSGRLPLALALVTARAAVLPGTTLTAIAAELATTRELVGFGPDAATDLRVVFSWSYRALTPDAARLFRLLPLHPGPDLTPVSAAALAGIDTRTGVALLGELTSHMMLHGRDGRHQLHGLLRAYAEYLSEKLDDPALRRAATLRVFEHYRRAAHAAHRWLEPQLPAPQPPPAPDGVMPRRFLGQDDAMAWFTAERQVLAAIVTQAQDAPALAWHTALAMQDFLHFSGRTPEWAAIARAGLDAAMADGDVEGQARLLRSLSGALFMLRDLDEAMTHLREARRIVESIGDDTQLAAVDLNSAYVQGAQRRHADAIRHGEHALDTYRRTGDVRNQAAALRVIAANVAALGRRDEAVDLLRDALALSNADDDVRGAGHGLDLLGKTYRQVGDRRNAVVHWHRAAESYRRAGTPAARAAVLLAIGDLHHQTGDRNAGRAAWIEARDALGDAAGPLVRALQSRLVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTW4</accession>
    <name>A0A010ZTW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1706"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459179" evidence="1">
        <location>
            <begin position="27"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="32784" checksum="8C0D5D4030939BD6" modified="2014-06-11" version="1">MRRRTFLSATAVLAAATVAGCDVVDADENHTIGLAEASTTIPFLAVMDDAFTARAKEHGMKTVILNGELDNAKQAANIETLIAKQVDLIVVVSSNPTAVIPAIKHANRVGIPVIALNAKLDEGAELVSYVGCSDYQYGQGEAKLLVEALPNGGDVAIVLGPPGDSPTVQRLAGMKSVLASHPGIRIVATPSDGFDNSRNLAVTQDLLSKYPRGTIDAIVAEGPQMYVGAEYARKNGRDDVVFIAGDYSKQVEAAIKSGALYGTVDQSPVLQGQRAADFAWRKLTGKDVPKESLIPLPAITRANVAANPAEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUC1</accession>
    <name>A0A010ZUC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570399.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123580_0_0_11"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="28696" checksum="270818B6168FE62A" modified="2014-06-11" version="1">MALGELSQQVLERLPRPVWVVDGGGEIAFANLAAAAELGWSDPHALNGLPSHETAHHRHPDGSDYARGDCRVLRRGTAFPYTPASDEWFIRRDGTMFPIAWACTPIELPGGPGMIVSFDDVSEQREQTRRHRGALWEAVRAELPHTRTTPDRDALLGRIRRFVAENATDPDLDPAALARAHHISLRLLQALFADSGSSPARFIRDQRLLEARRLLDEGESISRAGSLSGFPDPGTFTRAFRRRFGCTPSAFLNGYRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUQ1</accession>
    <name>A0A010ZUQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852222.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3568"/>
    <dbReference type="HOGENOM" id="CLU_045011_19_2_11"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="23978" checksum="8D2B3541955361E8" modified="2014-06-11" version="1">MADTAIFDVDGTLVDTNYQHALAWFRAFRRFGITHPLWRIHRGIGMGGDMFVPEVGGRDIEEAHGDDLRKAWAEEFDRLIDEIQPFEGAHDLLAEVKERGFRLVLASSGRTDHVDRFLDLIDGKSLADAWTTSDDVAKSKPEPDLIATALAKVEGASAVMVGDSIFDAQAAAKLQIPTLGVRTGGFSVGELQEAGVLQVFDSLVAFRQALDGTPLARASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUW1</accession>
    <name>A0A010ZUW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570542.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3635"/>
    <dbReference type="HOGENOM" id="CLU_040514_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="360" mass="38103" checksum="6CB5E1BC8C72B1E1" modified="2014-06-11" version="1">MRTRQTVLLIFGVLSLVVTLVLLAIAGPLLWAHATRRDADGFYVLPSQRLASPTVAITSEPMAIFAHMHGGYADRMTDRLGTVRVTADDLGGHDVFLGIARTADVTAYLSPASYDVVSGVYGGRADYRRHDGAGALSGTPAEQAFWVASADGAGRRTLTWSVRPGDWTLVVMNSDANPGVDVDARAGLRTDALLPAGGWFLGAALVSALLAAGLLVGAVAGVSHEPGPAPGTGTPGAYPVRVDARLDQPLHRGLWLVKWLLAIPHFVVLAFLWLAFGLLTVVAWVSILLTGRYPKGVFAFNVGVLRWHWRVVYYAMTLGTDEYPPFRLDTGGTDPGSVSVLPPAPPAAPAPATGDELARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUW6</accession>
    <name>A0A010ZUW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852315.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3642"/>
    <dbReference type="HOGENOM" id="CLU_114557_0_0_11"/>
    <dbReference type="OrthoDB" id="1853589at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20991" checksum="A30EFF75F9BA2946" modified="2014-06-11" version="1">MATTHGKQHRLHIPDSLHLTAPDSPAALYDTPDGRTATATRIVLAATRIVVGWTFLWAFVDKVFGLGYATPAGKGWIDGGSPTQGFLANGAKGPFEGLYHDLAGTAFANWAFMLGLLGIGVAMTLGIGMRIAGVSGSLLYVLMWTVALPPENNPITDDHILGALIVAALVLLGAGNYFGFGTWWRQTALVQRFPWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV42</accession>
    <name>A0A010ZV42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type proline/glycine betaine transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2138"/>
    <dbReference type="HOGENOM" id="CLU_046113_7_1_11"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="23380" checksum="E938F265282CF168" modified="2014-06-11" version="1">MNVVSRAIHWFGEASQWSGTDGIPARVGEHLYYSGLSLLIAALIALPLGLYVGHTGRGAFLAVNSAGAARALPTVGLVGLTVVVFGIGLTPTLLPLVALAIPPILVNTYAGVRQVDAQLRDAADGMGMTGFQVLFQVELPVALPLIVLGLRTAAVQIVSTATIAAYVGLGGLGRYIFDGLARREYEVMIGGAVLSVLLALGTEALFVGIQRLIVSPGVRQRALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWJ4</accession>
    <name>A0A010ZWJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2670"/>
    <dbReference type="HOGENOM" id="CLU_062618_6_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="25924" checksum="A65259D44A949FAD" modified="2014-06-11" version="1">MQSIERAAAILRLLGAAPGPLGVTEIAEALGLAKGTTHGLLRTLHRVGFVDQDGSGGKYRPGASLLDLGSGPLDLNELRSHAINWADPLAARTGFAVRIGALQAGAVVVVHHVFRPDDTQQRLDVGSSLPVHATALGKALLAYAPNASVVLAQGLPPYSHRTITDPDELRASLDRVRRRGWATEIEEMTVGQAGVAVPIRGHGGLVVGAIGVSGAVDRVCDPGLRPRNALVNRVRDAARAVSRDLAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWT8</accession>
    <name>A0A010ZWT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851107.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2769"/>
    <dbReference type="HOGENOM" id="CLU_046006_2_1_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15891" checksum="E1C8DB24739A3023" modified="2014-06-11" version="1">MTVRRMDNVLIVVEDLDAVTAFFVEIGLELEGRMPVEGRWVESVIGISDVRQEVAMLTVPGGHGRIELAMFHTPEAISGVPIDAPANTLGIRRVMFAVDDIDDVVARLCARGAELVGEVARYEDVYRLCYVRGPEGIVVGLAEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYE0</accession>
    <name>A0A010ZYE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570375.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3334"/>
    <dbReference type="HOGENOM" id="CLU_080168_4_0_11"/>
    <dbReference type="OrthoDB" id="1857091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="23456" checksum="5BD9DDF94A004CF5" modified="2014-06-11" version="1">MNAVDVTLAEDLLLLLFRPGSGSFTGETTLGHVLAGAVLADLAHGGHVRPLPGWGGSIRVEAVAGRRPADEILSSAWDQIAAGPRGAQAALAVIGSTVRAAVLDRLVRRGDLRRCGRAGAFVVRPGGSGRRGRLVAEVRAVLVDGADPQPRAAALVALLSGSGTLPQFDPEIPWTPPVVARAQTLQRGNWGAATTADAIARTVTEAIVGNVAVAGWTVWRERRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYN1</accession>
    <name>A0A010ZYN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851989.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3424"/>
    <dbReference type="HOGENOM" id="CLU_039929_1_1_11"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="29672" checksum="A512BCAC43F85376" modified="2014-06-11" version="1">MQVFVQTLVGGISLGAIYALVALGFSLVYRTMGLVNFAHGNVVMIGAYLASTFYLSVKLPFALAMVVAIAVTGLIGVIIERVLRPLENKDFDLMLIGTIGFGIVLDACAILIWGATGRAVPSPVRSAPLDLFGIRVRTYDLVVLAVVAVATVLLVLFLQRTKRGAAMQAVAMDHEAATAVGIHVGRSNAIAFVIGAGLAALAGGLVGPLLYVSPSMGGALGIKGFAGAILGGFGSIPGAIVGGIAIGVLDSFAAGHFQGYSELVTFVVFAVLITVRPTGIFGEKTVNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZG7</accession>
    <name>A0A010ZZG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570609.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3781"/>
    <dbReference type="HOGENOM" id="CLU_080422_1_0_11"/>
    <dbReference type="OrthoDB" id="1497902at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459229" evidence="2">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="22974" checksum="384397E35574ADC8" modified="2014-06-11" version="1">MIGIIGTGSGAVVNRRAAAALAASSAVFFTAEFVAAAAWSDPPYSYTHHFVSNLGVHGPATVFGQFMYSPLAWVMNTGFVLFGLAALAGVVLLRGLPPRRRRVVVGLGAALGVGGVLVGLYPGSGDDGTTDYHGLGAMLAFVAGNVLSVLLGRSYRYLGVSRRLGRVLVGLGVVGLVSIIAFAVVLGSGAGILIGLAERGILYPFLIGFVLLGRALWFTGPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A079</accession>
    <name>A0A011A079_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852948.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_1_1_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="38705" checksum="02C82B162855D6B6" modified="2014-06-11" version="1">MAAKEYGIFLPIGSGGWMLSTTAPHPEATYAYNKRAARHAEAIGLDFIMSMAKWRGFGGTTDHWGESLESITMMSALAEATERVKIWATVHANVHNPGIAAKMFTTLQQISGGRAGMNIVNGAYAAEFVQYDLWSDLSKEDRYRMTAEWTEAVLRLWSEHSVTLDGEFYTLRDAESRPHPEVRPTIISAGQSPAGRAFQAAYADGAFLSANSLEDMRDFSRDVHRKAADAGRDVKTYSMLMVVQDETDAGAAEKVRRWSEGLDREALAAMRESWGFPEDRARAWAEGATGSAVFQTPYVSGSADTVVEHIRTIVTEAELDGLMLIFPEYDQDMLLFGETVLPVLRKLDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0G4</accession>
    <name>A0A011A0G4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trk-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853111.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4163"/>
    <dbReference type="HOGENOM" id="CLU_026429_0_1_11"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="46331" checksum="F66476AE3236FE7F" modified="2014-06-11" version="1">MRGNTPRPARAVVLVFLGAIAAGTALLMLPASRRGDGAAPLLTAFFSATSAITTSGMSTVDIATYWSGFGHVLLAVLTQAGGFGITAAATVLGLLVSQRLGLRGRMMAGAETGSGVAHGDVRRVLVLAAVVMFASEAVMAVFVTGRLWLSYRVAFPSALREGLFNAVQAFNNSGFSLRSEGLSGFVGDWWICVPLTLGVIVGGLGVPVLYEIAKELRRPAAWSTHTRLTVWGSLVLLVVGFVTVLGFEWNNALAPLGVADKVLASFVQGTIPRSGGFNTLDYGSFDQDTSAIVTGLMFIGGGSASTAGGIKVTTFFLLAFVIWTEARGERDVVVGRRRIAESTQRQATAVALLGVAAVAAGTLLLLRLTADVTFDRALFEVMAAFSTAGLTTGLTAELSGPGQLVLIVMMFVGRVGTVAVASALALNTRHRLYRYPEERPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0H3</accession>
    <name>A0A011A0H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853130.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4173"/>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="713" mass="73100" checksum="663C1C19F5B29808" modified="2014-06-11" version="1">MATLLHRLGRGAFRHRGVVLGAWAAVLALLIGLVVGVGGSLDNDFSIPGSESQQARDTLSREFPAAAGATAQIVFSAPAGERITDYTAVVTRTLDRVTHAPQVEAVQTGAVSADQRTSLAQVEYAVEHPSDPEALEQAVEPAERAGLTVSVGGAAFSENGVSVSALELIGVGVALLVLVVTFGSLLAAGLPLVTALVGVGVGLLGLLATAAVGNISSTAITLALMIGLAVGIDYALFIVSRHRTQLARGMDPEESAALANGTAGSAVVFAGLTVIIALAGLSVVGIPFLTVMGLGAAATVLVAVLVALTVVPALLGFAGARLVPKPGSRAERRGAPDTTSGGERWARIVTRRPAWTVLAVVVGLLVLAIPAKDLRLALPDGGSAAEGTHQRVTYDAVSEAFGPGFNGPLLVLAHGDADRAALVAKDLGALTNVVAVTPPVPTPDGEYALIQVIPRTGPDAQATTDLVDTIRDRAGAIEAQTGVRVQVTGNTAIAIDVSDRLSAALVPFAAVVVGLCLVLLLVVFRSLVVPLKATIGFLLSVGASFGATAAVFEWGWLADVLGVGRTGPVISFLPIILMAVLFGLAMDYEVFLVSGIREEWVRTGKALASVHGGARHASRVVTAAALIMFSVFATFVIPDDAIIKPIAFSLAVGVLIDAFVVRMTLVPAVLALVGRGAWWLPGWLDRLLPRVDIEGESLRGDEETAPKEPVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAJ9</accession>
    <name>A0A011AAJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Prephenate dehydratase</fullName>
            <shortName evidence="10">PDT</shortName>
            <ecNumber evidence="3 10">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheA</name>
        <name evidence="13" type="ORF">CryarDRAFT_0064</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847441.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.59"/>
    <dbReference type="HOGENOM" id="CLU_035008_0_0_11"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32942" checksum="86750D646C3B3159" modified="2014-06-11" version="1">MSVELTRYAYLGPAGTFTEQALRTVPETAGAELLPMVTVPEALQAVRDARADAALVPLENSVEGAVPPTLDGLAGGERLMIKREVLLPVTFNLYASAGADLTTVKTVASHPHGLAQCQGWLRRHVPQAELITAPSTSDAAEGVVRGDWDAAVCAPVAGQRNQLEELAVDVGDNAAAVTRFILVTRPMRPPAPTGADVTSLVAFIAHDRTGALLEVLTEFAVRGINLTRIESRPTKERIGRYCFFLDCDGHIEDARVGEALMGLRRVCADVRFLGSYPRAGADHEGDGRAEPSDADSDAAGWLARVRAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAU3</accession>
    <name>A0A011AAU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847605.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.162"/>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458625" evidence="3">
        <location>
            <begin position="29"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="90"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="5">
        <location>
            <begin position="394"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="536" mass="57229" checksum="AB7F6B34C189289D" modified="2014-06-11" version="1">MGRRSALAVVGIALAGLISPALVSPAVAAPLTAPQAQAPAPITWTACATETYPTLQCGKVSVPLDYDNPSGRKITLAVSRIPHTAAKSQGALLVNPGGPGGSGLSLAGFVAKNLPKDVAAQYDVIGFDPRGVGKSEPALNCAEGFFKPVRPDSVPKTKADMEANLKRVKSLAAKCGAKYGSLLKYIDTLSAVKDMDQIRLGLGAKTINYFGYSYGTYLGAVYAKLFPKNVRRMVLDSVVDPTGVWYEDNLQQDYAFDARHEAFAAWVAKHDANYHLGTSEDVVLEKWYATRAALKAKPAGGVVGPSEFEDTYIPGGYYNGYWPFLADALAAYVNNKDEAALVDVFEAFGAVDASGENGFSIYAAVQCRDAKWPKNWSTWVNDNWEVYKKAPFMAWNNAWYNAPCAFWPVKSLHPIDVSNSKVESVLIFQATDDAATPYPGAEVVRRKIKNSRLVVEQDGGNHGITLSGNACLDKYLADYLATGARPEGSGIVDATCAALPDPEPPAATAQAGSTAKAASRAGRGTLHEYVATRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABD2</accession>
    <name>A0A011ABD2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="12777" checksum="D524BA985A4F0FCA" modified="2014-06-11" version="1">MSLQVSVEHVDGVARCEIVGEVDMATTPQLRDELLGLVDAGHKYLVLDVSGVPFLDSTGLGVLMEVHRRLRDNSGAAALVGARPALVRLLTITNLSRALPVYRSVEDASAAVTGSPAAEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABD6</accession>
    <name>A0A011ABD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.329"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="34878" checksum="342602B7C18225D0" modified="2014-06-11" version="1">MQNVTIGDVAKAAGVSPATVSRVLNANQGVADELRQRVVAAVDQLGYQPNSQARSLRTRATSVLGLIISDITNPFFPEIARGVEDAAHAAGFSVVLANTDEDLAKEQRYLEVAAAERMAGVVLAPASSAETDIGVLRSRGIPVVTVDRRLLGHPVDSVTVDNLAAAREATLYLVGTGCRRIGFVGGPLATTTAADRLAGYREGLAEAGLPFDPDLVAHGDYRIDGGRTASKHLLQLSPDALFVSNNLMTIGAITALDDAGLRHPHDIALVGFDDQTWQTGLLPPLTLVTQPTYELGKRAATALLDRIRTPEAPPNDVVLPATLAVHEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABK4</accession>
    <name>A0A011ABK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxybenzoate polyprenyltransferase-like prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080174_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="25268" checksum="47D2A43B91BC5839" modified="2014-06-11" version="1">MTAGVTALAAAAGRPAAGLVAVALAVLSGQLATGWSNDWLDAERDAAVGRTDKPVATGEVSRSLVGTAAVVAGLACVPLSLLSGWRAGLVHLVAVACALAYNARLKATPFSALPYALAFAAAPAFVTLARPGHPWPPAWLLVAGAALGAGAHFANVLSDLDDDAATGIRGVPHRLGRPAAEAIAAGLMALVAVLLTVGPPGPPTPLAWSILGTTAVVLGAGAALGRRRGSRTLFRAVLITALGDVVLLLLSGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACF1</accession>
    <name>A0A011ACF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.742"/>
    <dbReference type="HOGENOM" id="CLU_062618_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="93"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="28964" checksum="4AE8027C7FA2E562" modified="2014-06-11" version="1">MLEPVPEIAPVSPAPGDEELPRAERGTPAIQAVERAATILGAFSVGRPRLSLNELTARLGTSKATAHRYTKALRSVNLLRYDEREALYSLGPQVLTLSAAARAGLPIITIAGPYMEELVREAGETVVLSVWDGDTAVVVRVDDNTDRTVRISVRTGARLSMSRSAQGRVFCAFLDEDEVPGLGSLLRRNPDLRSELEAIRENGISVNTPADNGVRTIAAPVFQDATIVATMAIVGTTAAVADETGSPAAQSLLHISRSLTQELGASGPITRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFQ5</accession>
    <name>A0A011AFQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861523.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1915"/>
    <dbReference type="HOGENOM" id="CLU_028255_0_0_11"/>
    <dbReference type="OrthoDB" id="1292731at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="376" mass="37272" checksum="C6388AFB9754AC81" modified="2014-06-11" version="1">MRVLVAPDSFGGTLSAGEAAAAIAAGWAREAPDDTVVTRPLSDGGPGLVEVIRATLGGELVPVAARGPRLEPLDASFLLLDGVAYLECATVAGLQLVPEPERDPKVTTTYGLGLLLAAAVEAGARTAVIGLGGSVTNDGGAGLLAALGAGPVGVSGTALPPGGAALRVCEGLAGVPALRGVEIVAATDVDNPLTGIHGASAVYGPQKGASDNDVQILDAALEHWATVLERDLPGCPPGVGLLPGAGAAGGLGVALLALGGRREAGIGLVRRLIGFDTAVADADLVVTGEGSFDYQSLRGKVVAGVASAAAEHGAPCVVLAGRVAVGRQEAAAAHVDETRSLVDHAGLDRAMNDAAEVLSDLAARTARDWSRARPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG86</accession>
    <name>A0A011AG86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superfamily II RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850181.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2097"/>
    <dbReference type="HOGENOM" id="CLU_017075_0_0_11"/>
    <dbReference type="OrthoDB" id="66530at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="219"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="837" mass="91620" checksum="6E604A92E8ECF76D" modified="2014-06-11" version="1">MTLTELLPSTPDPDEIFEAFAGWAEKQGLTLYPHQEEALIEIVSGANVILSTPTGSGKSMVATGAHFAALATGRRTYYTAPIKALVSEKFFALCDVFSPAQVGMLTGDASVNADAPIICCTAEILANIALRDGAAADVGQVVMDEFHFYAEPDRGWAWQVPLIELPQAQFLLMSATLGDVTRFVDDLSRRTGRQTAVVSSAERPVPLFYEYVSTPLHETLTELLETRQAPIYVVHFTQAAALERAQALMSINVCTRAEKDAIASAIGSFRFSTGFGKTLSRLVRHGIGVHHAGMLPKYRRLVETLAQAGLLKVICGTDTLGVGINVPIRTVLFTGLSKYDGVKVRLLKAREFHQIAGRAGRAGYDTVGTVVVQAPEHVVENERALAKAGDDPKKRRKVVKKKPPEGSVGYGKPTYERLISAEPEPLTSSFTVSHAMLLNVIGRPGDAFAAMRHLLTDNHEDAAAQRKHIRRAIAIYRALLAGGVVEKLDSPDSEGRSVRLTIDLQDDFALNQPLSPLALAAIELLDRESPSYALDVVSVIESTLDNPRQVLSAQQFKARGEAVAQMKADGLEYDARMEALEDVTYPKPLVELLGPAYETYRRGHPWVADYELSPKSVVRDMYERAMTFTEYVSFYSLGRSEGLVLRYLADAYRAIRQTVPEEARTEDLTDLIEWLGELVRQVDSSLIDEWERLTSPGDELAEVAPIESAPVAVTRNTRAFRVLVRNALFRRVELAALRNWWELGELDSASGWDTVAWEEAMTPYFEEYAGIGTGPDARGPALLSISEEAGLWLVRQTFDDPAGDRDWGISATVDLSASDEAGVAVIEVTSVGPLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHC9</accession>
    <name>A0A011AHC9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">CryarDRAFT_2540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862024.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2501"/>
    <dbReference type="HOGENOM" id="CLU_079959_0_0_11"/>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24194" checksum="74D5851ABF5BE315" modified="2014-06-11" version="1">MNTGFRGVIAVDGPSGSGKSSVCREVARTLGLRYLDTGAMYRAVTWAALDRGLDLTDQPAVAALSRALVLDVATDPASPRIAVDGVDVTAAIRQTRISENVSAIATNLDVRSDLIARQRALIEEKGAGIVAEGRDITTVVAPDADVRLLLTADENARIARRARELHGNDDAASLAATHAQIATRDARDSTVVDFLVAADGVVEIDTSPLTFEQVVAAVLRVVSETAGAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHG8</accession>
    <name>A0A011AHG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725706.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2544"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="287"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="545" mass="56951" checksum="6C0E425449F9A082" modified="2014-06-11" version="1">MASYQAAGSSTAARRNPLVRWLADRPVKVKLIIALGVLAVIAIAVGLVGIRSLAETNKDSQHLYNENVISMIALGRVHQEELKTRMLVNGHASALDAKTMAEWETKIQESDAELAKWEAEYEKAGPEDQATWNEFKVAWKKWQDYRDSTLLPLSRTNQNEAFNTALTGTSADLTGAAADLLDELEAYDSGLAKQTADKAGDAYRSARIAVISLLVIGLLVAGALSLVITKLIVAPLRRVSGVLDAMAAGDLTQNAQVHSKDEVGQMAASLVRAQDGVRQAITALAQSAETLAGSADELTNVSQQIADTAQDASSQAGVVSEASEEVSRNVQTVAAGSEEMGAAIREISQSANDAAGVASQAVSAAAATNATVAKLGESSVEIGNVVKVITSIAEQTNLLALNATIEAARAGEAGKGFAVVANEVKDLAQETAQATENISKRVEAIQADTDSAVAAIEQISGIIAQINDYQMTIASAVEEQTATTNEMNRSISEAAMSSSQIAANISGVAEATQQTSGNAGDAKAAAERLNAMSADLRALVGRFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHI1</accession>
    <name>A0A011AHI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatinine amidohydrolase family protein, mycofactocin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051572027.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2560"/>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_11"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023871">
        <property type="entry name" value="MftE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03964">
        <property type="entry name" value="mycofact_creat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="23622" checksum="9EA4662734D3FB25" modified="2014-06-11" version="1">MSELADRVWPEITGAGVLAIPVGSTEQHGPHLPFSTDTDIAVALARALAARRADVLVAPAMPYGSSGEHQGFPGTLSIGPSAIETVLLELGRSATETFGRILFVSGHGGNAIPVNRAVRRLRSEGRDALAWAPRWRGDAHAGRTETSVQLALDPSRVRLDRAAPGNTAALSELLPVMREQGLRPVTENGVLGDPSGADADEGARLLTEATDDLATTVSRWLGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ33</accession>
    <name>A0A011AJ33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3121"/>
    <dbReference type="HOGENOM" id="CLU_590143_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="463" mass="50903" checksum="BED355E61034C152" modified="2014-06-11" version="1">MSLADVDGAAVRKAIAEHDEIGQTEFLRRHGFRPALRYQVLHDGRRYDSKAILGVAHQYATGAPLAAAQFSGGEATVVRRLEQLGFTIDDVDAKPDATTGPNRPAPESLDASRPPLVLIAPSTGNKAARSRFSDTLAQPVDYTDDRLRNALSDSERASLERLHPDGRARFWGALPRFNTTIDRLRQGDVVVFTGQNHVVAVAALGCKLRNRQLADLLWPPASGHEGWLNVYTLVGFQLVHGVGYPQLRDWVGSSDNDIFQATRGLSPEKSAAVITGLGLTIHPDEDTQDAQAEAQLLAALDSARTPASQLSAAENNQTTTSSYNQPARTITIHRAEAELVNLFRDTLPGHSGDHRLRTAVGHTDLYLLDDGDIIEAKRGADHRYVRQALGQLLDYAVNTDQPVHRLTALFPASPLSADIQLLHCYGIDCLYWNRDTTFTREPASDTTREIMRPLWTMVLNHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJR0</accession>
    <name>A0A011AJR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851895.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3345"/>
    <dbReference type="HOGENOM" id="CLU_1218153_0_0_11"/>
    <dbReference type="OrthoDB" id="1427241at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25763" checksum="25E1ACA1BA697A57" modified="2014-06-11" version="1">MTTIQSLAFLTPGNYPDDDPYLGLENTLRQFEYGEQLGFDGAWIRQRHLEHGVGFSAGTPPHAELIGHLAFDGDWRTYDLSHNRVSRLVDNLRGDFIGDESTVIHSPGNIQRPRVQPYSPGHVITGEGTDDFTTRKRYLAYAESRYERTLAPNGPKRILFFRDLVGPTEQILEQLSADPVLAQVSDFQIELPYEFEHEDYLQILHDVRMHLAPELGWRPPSGSEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJX9</accession>
    <name>A0A011AJX9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3390"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1057" mass="113800" checksum="49645BEFEA080442" modified="2014-06-11" version="1">MIGGVDVSPGTPAAGGSARSDILGSLRIRRNGVEVDLGPRQQAYLLGLLLARAGQPVSVDDLIELIWDDEAPPSALNVVQRYVGALRRLLEPELPARSNGAYLRRHSNGYLFVADTEASDVAAFRALVAAAHRRLAQREPRAALDDFAAALALWRGPAGDGLNPGRAAAPLFASLNEEFFTACSAAAELAVSLGRPQRVLRPLRLAASMAPLHERVQAALVTALAAAGQHAEARSLYERVRARLAEEIGIDPGPAMRDAKRRIRDRPATPRPAAAEPASKLVGRAAELSVLRQAVASVLASGTGLLVVEGDPGIGKTRLLEETAGEATRRGALVVWGHCLEGDGSPSMWPWVKAIGAILDTLPDPSREEWLAGRLGRLAEPDDGVSDTPVLPDNTAQFRLFEHVVHAVGQAARQRPVLLIIDDLHWADVASVQLFGHLAARLPSGVLLIGTLRTRAPLPGTELVGMLAAASRVPGHRRLRLDVLDRDEVAELVRRETGQVPDAAVTRTISARTAGNPFFVRELARLLTADGGVLTERSAVSTGVPSTVRDVVRDRMAGLDDRATDLLQIAALVGRGVDLRLLAHAARVDVQTSLGLLEPVETLGLLEPAPDDPFAYRFAHDLVRESISETTPPLRAPRLHLRIADALEQTPGRSVAERLAHHLWAAGPLADPARTTAALIRAGRSAATKLALQDAERQLRSAARLARTSGLRELELSALSHLTAVVGMRAGYVGAALDLLERAEQLARDLGRELEAADFRFSRRAAYSEAAQLDRSGPLARRLLEEGQASPDPVLRAYGLVSWGIQEWDRGNIGEAFRYLRKADPLVLDELTWRDENRLRRDLQLKSPVMLALVTTLHGDVDSARTVIERLEATAGDDPYVVTIWSTFAATSAALAGEPAWALRSAERGIAEDPGFSFVFFGAYLRMARHWAHAVTGDDPAGAAVEAERILSATLVDPPLSGVATWYGLIAEMWLAADAPDRAEAALVRAEHFLGVNDQRYAEGLVLLLRARLLQARGAPLADVRAAAERARVLSGQREAYLFARRAQEMLDALDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL04</accession>
    <name>A0A011AL04_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852570.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3805"/>
    <dbReference type="HOGENOM" id="CLU_077795_1_1_11"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21239" checksum="B6A59E7B4CF7E93D" modified="2014-06-11" version="1">MTTTELARIRVLPVVVLDDPRHALPLARALADGGVPCAEITLRTPAAVEAVATVAELDGFLVGAGTVLTPEQFDRVVDAGARFVVSPGFSAVLSNRASRRGVPAIPGVATASELMSARAAGHTVVKLFPAAQLGGAALVPALHGPFPDVRFVPSGGISISNAAEYDLEPVLTVSTSWITPRDVIAAGRFDEITARAREFRAAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFX4</accession>
    <name>A0A010YFX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069063_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="35279" checksum="9DA6683BD881E8DE" modified="2014-06-11" version="1">MTYVSDEARENFAKALDAADRRLAVELVSELLNDGVDPLDLLLDLITPAQQIVGERWQSGEYTVAQEHAATAVSEAAVGTVGAWIPEAEQPVGYAVVACAEREWHALAARIVTESLRHLGWRTTYLGASTPAHHLAGYLHRLDPDVVAVSCSMPAALPAARRIIEAASEAGIPTLAGGRAFGRGPSRALALGASGWAASPREAAGVLTELRPIVEPVPALAHAGADEQAELLLRNRELAARVLKEWLVALEGIGADCLAGLDAEADYAVDHALHALAAALLTDDVTVLVEGREWLTTLLAARGCHADAVPQLWTVLSRVAGSQLPVASKLLGQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGI2</accession>
    <name>A0A010YGI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.369"/>
    <dbReference type="HOGENOM" id="CLU_407549_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="674" mass="65925" checksum="BA367A7CA550D8B6" modified="2014-06-11" version="1">MQWRRDLWLAILTIGTVAFVVGERILSTSDEPGLVTPVLVIGAMTAPMAFYAACRGLHFTVPTWVVVASMAIAAALGSVMSGLLGYYALADLGPVATVAVSLVEESVTLLVPLAALFALPTRRASDGLLVGAAAGGGFAVAQTVGYLVTLPSVVGPAAHDVLVRGLLAPAAQLAWGAITALALWLAAQEHWNGRSLRRLVLAITGVVALHALWEGVHGVPGRLLLTVLSGVLLGWVVVRTVARRGVSTRVLSRSGVSSARVGAGGKPGSAPAKPGSAGSHPGGAGAHPGGAGTRPDGSGARPDGAGVGSGGAGAKSGRGMPGGAGVRSGGAGVAHRAEVKADGAGGAEPGGAGVAPRAGGAAAPVEGREAVGAPAGTVAGGTVAGGTVAGGTVAGGTVAGGTVAGGTVAGGTVAGGTVAAGTVAGGATSGMAAAVASEHAVVEAPLRTAGGAVVAELTLTDAHSAVETLVDAEVAPEPTHTVANETLGAVESTDAALPAVTPVTEVNTEPLQAPLTGLAEGEWEQTLPAGSTDIPAAEHPAVNAQEPRSTAPPTPKKPRSTAPRTTPRTPDEPLPTAPRTASKPLSDAPRTAEKPHPTAPRTADKPLSDAPRTAKAPRSTAPRTADKPSGTKKPNGARKPGPAAPRAKKSNAPRPASRAATTEPNQARPTSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGR5</accession>
    <name>A0A010YGR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848136.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="169" mass="18929" checksum="ABCC36E30F09E738" modified="2014-06-11" version="1">MEDEEYHEYVRSALPVLRRLAYVLCQDGHRADDLVQNALVKLYLAWDKARRAENRNAYARTVLVRVFLSERRANWARRVVLVDRLPEQASVPGPDPAATLALRAALATLPPKQRAALVLRYYADLSVDETAEALGCPANTVKSHTARGIAALRRVLPEEVAATQDWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHY2</accession>
    <name>A0A010YHY2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_11"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="199"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="44017" checksum="D4C52F5F797DB7B2" modified="2014-06-11" version="1">MIISGGMSTDLLGMGTQHFLDTALADLQPLRPLPMALLESLGVLLAEDVVAPGPVPAFDVAAVDGYAVRAHDTLGDAQWSGDPSQHHGDVRLAVIGDLTAASWEPATVSAGASYTVTVGTPLPVGADAVVAGEVTDGGLARVRIGRVPQPGDGIRRRGSTVAAGAVLAPARSRVTAATIALLASAGVESVLVSPPPRVLVAATGDELVDSSRPGYSTSAPGRIVDVDSLGVAAAAREAGAHAHRVGIVPDEDEALRRLVEDHAHRADLLVTTGGTGAGHTDVLRRLFGLDDVVHFETLPLEPSLVIGYGRVGPSRMPVLCLPGDPAGALLGFELVLRPMLRRLAGASSLFRPAMLAELTSPIRTMPGVREFRPARVVRSGEGGYLASPLAGGEAFLTGYASANALLAVPEAAGDVATGTDVPAFLLDGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ25</accession>
    <name>A0A010YJ25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849033.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1271"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="33472" checksum="A9A9E5B02EBC2613" modified="2014-06-11" version="1">MSGSRQRGEARTGWALLTPTLLIVLVVVVAPILWTILLAFQRVRVIDLRRRGLIGEFTFQNIERVFGSPGFWDTLWTTVAYTVFGVAISVGLGLAAALAVRRPFRGRTFVRASFLLPYIAPVVGATFVWQTMLNPEYGVLNAWGTRFLGWDRPVDFLNEVSGSLFGIPVPTALVTVILFEGWRYFPFAFLFLLARMQALPSDLEEAALVDGATPTQRFRHVVLPQLLPVIAVLTVLRFVLTFTKFDDVYLLTGGGSGTEVVSVRVYDFLTSRGDIGAASAEALVLAIALAVFVGIYLRLVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKY2</accession>
    <name>A0A010YKY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2971816_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="58" mass="6107" checksum="B5EF3EDCCD4015A8" modified="2014-06-11" version="1">MPGMSSMVTVTLKTPWTDSAGIGHPEGSTVRVPETVLDELVSTGVIVTDATETWVTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLE1</accession>
    <name>A0A010YLE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with CBM13 carbohydrate-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540411_0_0_11"/>
    <dbReference type="OrthoDB" id="1307506at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458119" evidence="1">
        <location>
            <begin position="26"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="155"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="329"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="487" mass="50882" checksum="7365C66587FC0953" modified="2014-06-11" version="1">MLLTLVALSLSTLVLDSVVRQTVLARTEIARAEALNAAQSGLDVGMAHIRSANDGTVAGVLSKLPCASLAGTVTSVLRGSYSVSVRYYAQDPQGQPASWLSGASRITCAPSQGVARTPAYALLSSVGSYSAGLGATVSRTLTAVYTFRTTNQSIPGGMIHVYRANTSETDLCLDAGSATPASGTAVTLQTCSPGLAAQNFAYDNKLRILLLSSRTTALPVGVCLDSATPHAVGNPVVVANCTTPTVQARQQWSINDSANFEGTTNGSSLDGFCFNAKFPGVEGSPVVLGSGSNCRRSYNSTQSFFPDATVGPGAAGPTNSQLVNLEQFGRCLDVTDQNVNQSFLIAWPCKQAPDPTYVAWNQKWTMPANGVSGQVVTKPGAQYCLRSPLLVGVGQYVRVVSCGTGGAALQWTRREADDSYPLSYTLVDSAGHCLSTTDPDANPPDLFNTGQRVTKIVVAACDGSARQKWNAPVTELQASPLKGVHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLJ8</accession>
    <name>A0A010YLJ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850278.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2163"/>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="12356" checksum="C67B5564BEDB2AC4" modified="2014-06-11" version="1">MVVDKGDADRIFAALADATRRDIVTRVLTREASVSALARQYEMSFAAVQKHVAVLERAGLVTKRRSGREQLVRGDIETIRRARELLRRYEEIWRGRVDRMNELLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLV9</accession>
    <name>A0A010YLV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850422.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2273"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="26565" checksum="363FEDAB6D293DB1" modified="2014-06-11" version="1">MTVFDLTGRKALVTGAAQGLGEGMALALAAAGAKVIVADLQDELGTKVAESLGEGHGFVHLDVTDDANWESAVATAAERLGGLDILVNNAGVEITSLLVDVEADQIRRQLEINLLGTTLGIKHAFRAMRPGGVAGHGGSVVNVASVAATIAFPGIAVYSATKSGVDRLTRVAAAESGRMGYGVRVNTIYPGLVPTAMGAGLANDVARLGLFASPEEAVGAVVALTPSGRLGEVTDMADAVVFLASDGSRFVNGAGLPVDGGMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM38</accession>
    <name>A0A010YM38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850511.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2323"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="474" mass="48101" checksum="AFFFAF28ED33C740" modified="2014-06-11" version="1">MRRSPWATLVVLALAQFMVVLDVTIVNVALPDIQADLAFTPDNLQWVISAYTLVFGGFLLLGGRAADLLGRRRLFVAGLALFGVTSLVGGLAQSQEVLIGVRALQGLGGALLSPAALSILTVTFAHGRERNIALGIWGGLAGLGGTLGVIAGGVLVDSAGWEWVFFVNVPIAAALVLVTPAIISESRVRTGGPRTFDAAGAVLATGGVLALIYGVIRAEPLGWSAGEVVGSLVAAVVLLAAFIVVERRSAAPLVPMRLFRSRGLSTATAALALNGAAFLAMFFLTAIFLQQVRGLSALETGLQFLPMGIAAIVAAVGASQLVARVGTRPVMFVGAGISVAGLWLLSQVDARGDYATDLLPGLILFGVGIMAVGTAAQIAAVADVRHDEAGAASGVVSSGYQVGGALGLAIITTLSTSHVTDLVSSGTAPAQALVEGFHRGLLVAAVFAGVNLVIALASPQLTPDAEQLAEAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM64</accession>
    <name>A0A010YM64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850563.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2358"/>
    <dbReference type="HOGENOM" id="CLU_053670_1_0_11"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="116"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="35303" checksum="C44DB356B11137A5" modified="2014-06-11" version="1">MIDLLVAGGGPAGLVTALLAARSGLSVTVLEPRALPIDKACGEGLMPHAVELLSELGVQVPGLPFRGIHYADARRGVDALFGAGAGRGVRRTTLHTHLTDAVAAAGIEIVPRAAGRITQDADGVQTAGFRARYLAAADGLHSPIRRALGLQRPSRGPSRHGLRQHYAVAPWADLVEVHWAPGAEAYVTPVAPELVGVAILTTARGPYADQLARFPALAAKLHSPTGPVRGAGPLRQRVSARVHGRVLLVGDAAGYVDALTGEGLAVAWAGAAELVACVAADRPGDYERRWAAASRRYRLLTGGLLWARNRPLLSRAIVPAAARLPRTFTTLVNHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN16</accession>
    <name>A0A010YN16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850964.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2673"/>
    <dbReference type="HOGENOM" id="CLU_015740_5_1_11"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="25"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="404"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="571" mass="62064" checksum="887113D6F0E0A1DF" modified="2014-06-11" version="1">MDTGRLSPEAREAAFTALADGDEVDVVVVGGGVVGAGAALDAVTRGLSVALVEARDFASGTSSRSSKLIHGGLRYLEMLDFGLVREALHERGLMVQRLAPHLVRPVRFLYPLKHRGWERLYAGSGVALYDALSLSSAGRGLPHHRHLTRRGALRVAPSLRKDALVGALQYYDAQVDDARHTMFLARTAAAYGAQVLSRARVVGFLREAERVTGVTVRDLEHDREFTIRAKQVINATGVWTDDTQAMVGERGQFHVRASKGIHLLVPRDRIQSSTGLILRTASSVLFVIPWGRHWIIGTTDTDWALDKAHPAASSRDIEYLLDEVNKVLVTPLTKPDVVGVYAGLRPLLAGESESTSQLSREHTVASPQPGLVVVAGGKYTTYRVMARDAVDAAVHALDRGAPKSCTDTVPLLGAEGFRALRNQRATLAARSGLHVARIEHLLSRYGSLLDELLTLMAADPDLRAPLDGAEDYLRVEIAYAASHEGARHLEDALTRRTRISIEVPDRGVAAARPAAELMAAVLGWSDEQVDREVEHYLRRVEAERASQDQPDDETADAKRLGAEDVVPLITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPD8</accession>
    <name>A0A010YPD8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851594.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3146"/>
    <dbReference type="HOGENOM" id="CLU_120069_2_0_11"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14339" checksum="3699FCB79F836017" modified="2014-06-11" version="1">MTDEAAQNPLTVLQKVQPPFVPADAEGVTFTIEYPPGHPGAAPHRHPGPAFGYVLEGEMRFELEGEPERVIRAGEAFFEPGGDVIHYQDGNHSDSTRLRFLVTLLCPPGAPMLTFVEESELAARRARRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPN1</accession>
    <name>A0A010YPN1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3245"/>
    <dbReference type="HOGENOM" id="CLU_139698_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="70" mass="7245" checksum="F4396CABA5C81EC0" modified="2014-06-11" version="1">MTGAIRVRADVETCVGAGQCVLSAPDVFDQDDDGIVRLLQDAPPPDAESAVRLAGRTCPSRSVHVDVAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPP7</accession>
    <name>A0A010YPP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3262"/>
    <dbReference type="HOGENOM" id="CLU_091585_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="21904" checksum="DFA6F41D26223D29" modified="2014-06-11" version="1">MLETLSRQWWAVALRGVAAVLFGVLALVWPEITVFALVIAFGAYALVDGVFTLITAFGDQTGERSGDRDGRRTPGRRAWLLARGIAGVLAGVIALIWPGITALALLWVIAVWAVVTGLLEIVAAFHLRKEMRREWLLALSGALSVLFGVLLIVWPTAGVLTLVVLIGVAAIAFGVTLLMLGLRLRQMGRPDPAATGHHRRPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ77</accession>
    <name>A0A010YQ77_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852056.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3471"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="32725" checksum="B12C6433C4DEF579" modified="2014-06-11" version="1">MSPSAVIEVDRLTISYGDFRAVEDLTFRVEQGELYALLGTNGAGKTSTLEAVEGHRKVSSGAVRVFGASPADRRAIRPRMGIMLQESGFAGDLTVAESVRLVGRLSGREDSVDRVLGVVDLHRKADVRVGQLSGGEKRRLDFATAVYGRPELIFLDEPTTGLDIQSRDALWEAVRDLRDHGSTVVLTTHYLEEAQQYADRIGLMHRGTFRHQGTVADLTRTLPSSIRFSLAPGAQAPPIGSPAADGLSYTIETFELQADLTALLNWAAARGVELRDLSAARTRLDDVFRAIEADPAPTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQA5</accession>
    <name>A0A010YQA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3511"/>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="34056" checksum="DFABBE99F8AE8F77" modified="2014-06-11" version="1">MVKNRQAIREIGFAAPAGVSRGVEVLSLAQFRSRVVSGPPRRPTFHHLLTIERGSLRHTVDFTGYTVSSGDWLWVRPGQVQQWGELGDVGGTLILFEPDFLDSATVAAARLGDTYAPVVYQPAEDERQRLTDAAVHLSRAFEAPGGLPLDIRQTVLRHLLAVLLLRLAFVPGDSTSEPGDTFRRFRDAVEHAFVRTRRLEDYARTLGYSSRTLSRATRAAVGINAKDFIDQRAVLEAKRLLAHSDQTAAQVAVRLGFSSATNFTKYFHQRTGTTPIAFRAAMRGAPHASPGPTPAHLASARQSSPPRGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQN0</accession>
    <name>A0A010YQN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monosaccharide ABC transporter substrate-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_9_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457907" evidence="1">
        <location>
            <begin position="28"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="99"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="421" mass="44008" checksum="231C5791C59D51E5" modified="2014-06-11" version="1">MYRPRALALVAIGLAISVLTACGGLSAEEPGGTDSTTGGYTALRTGKDATTTETDALAALPASVKDSYDGFWHSTRLGPSPYANWTPPKAPWKFCYSSAYQGNSWRAEGLTVARNIVAQLQTQNLVDGDLVVADANNNASVQATQVTTMVQQGCQVIFAMQPPSVGMCNAFDNANKAGALVVVMQTGTECTNVIQSDFAQYATGAKAAEWLVRKSGGKGTVVMCDGIPGVAAAEARQAAAAAVFQKAGLKVDRVTGEWTPSTIKSQMLSYLSTHAGEVAGVWDGGVCAVAVTEAFQQAGRTLPYVSGFEGGCAWLASWKRTGKESIGFTQGGGQGVVEAFKVALRLLAGQKSTVNTLLYPLPEINASNFTQYYKPQMTLNSGCNAQPLDGESVPDSYYDALFTGDAKPATFTAGLGALPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR44</accession>
    <name>A0A010YR44_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852600.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3832"/>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="33695" checksum="3AF6153C16E42D3E" modified="2014-06-11" version="1">MTDRDGFAAETGRYRRELLAHCYRMVGSAHDAEDLVQETYLRAWRAYAGFEGRASVRSWLHRIATNVCLTAVEPRVIRLLPSGLAGPSADPTRPPRPVDAAWLEPFPDAWISAPADDPAAVVVRRETLRLALIAGLQHLPARQRAILLLREVLAFSAAETAEILGTTTAAVKSGLQRARARLDELDPQPDDLLEPTDPRARALLDGYIAAFERSDANLLERVLRTDATLEATPFADWQAGRDHCVGLLERYVLGSPGDWRMIPTTANGQPAAVHHRGAPDGVVVLSPTATGVSRVVKFHEPALVTMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVB6</accession>
    <name>A0A010YVB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847535.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.110"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_1_11"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="7"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="404" mass="41101" checksum="75CCBB0FEF6705D4" modified="2014-06-11" version="1">MTKAISALIALSFSTFVYVTVESMPIGLMPLMSRDLDVSPSAVGMLVTAYGFVVVATSVPLAAVTRRWPPKRVLVVLLALLVVTTLVSALATAYWVLLGARLLTALSQALFWSIVTPTAAALFSERLRGRAVSALSGGSSLAAVLGVPIGAWLGQQAGWPIAFLAVSVLSLVLLVSVALLLPLSPASASSAARGTEPDAGRFWVIMGSTALVVTGSFVAFTYITEYLTDVNGFAPETIGPLLFVRGIAGVIGVAIVGLVVDRGVWPTMVAMVVLQAVALTLHYFSGDATSVAVVAVALGGLALTGWAAALGVRVLQVAPGASVLASAGTSTAFNLGITAGALLGGVLLPIVGVHSTALLGALLTLCALALLLAEPALSSARRSSRGRSSARHGAAVKGLRELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWD7</accession>
    <name>A0A010YWD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase, putative, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848130.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.484"/>
    <dbReference type="HOGENOM" id="CLU_021322_0_0_11"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="33371" checksum="487E2E2253743158" modified="2014-06-11" version="1">MPGNSQRPNRRKTGTKKGAVVGSGGQRRKALEGKGPTPKAADRYKHKANRSAAAAARRTSGPDKPRATPGRRGQGTREGAELLVGRNPVVEALRAEIPASALFLALGVDIDERINEAVQTAGDRGLSILEVSRAELDRMTGGVLHQGIGLKVPPYAYADLPDVLAAVEGAPLVVALDGVTDPRNLGAVVRSAAAFGAHAVVLPERRAAGMTATAWRTSAGAAARLPVARVTNLTRTLRSLQDQGFSVLGLDADGDVSTDSLEVGADPVVIVVGSEGRGLSRLVGEACDQLVSIPMTNDTESLNASVAAAVLLAEVARQRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWH7</accession>
    <name>A0A010YWH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635721_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026367">
        <property type="entry name" value="FxsC_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04276">
        <property type="entry name" value="FxsC_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="46949" checksum="2EFE9893EBE45302" modified="2014-06-11" version="1">MGPYFVVTHAATGTDGHYIRRLFADLVDAVGLRLAARNGPVGVLSGPRRVPAEADTTITPEVFATPVLIAIYTPEFLRSPHACGEWSIFWQRQLTNEQITGNKRSALLGLRWAPIDPVPAEVEQTVVRMDLGSALGDTIRHSGGQEPYPGLVRGLVDQIVTAAAPDRLVPAMSPDSAAQFTPRWVAAASPELLPSAPKKPGRASGATRVGLVVAAGAAEEQPPQRRDRQYYGADSAGWQPFLPGVETTALALAYRSIYDLDIGDVVAFPFDEGIVEQVRAAAETNRIVLVVVDPWVSRIDVYRQLLTWLGQQDLRNSTVAACLLVVNPTDVETSRHEAELLAGITEHLSLRRRAAAGRVDRFAVPTPQQLDAGLAEAVVGAQNALLRRRRLPADVDSGPVAARERASWITTPDHPWRPRLRRPVDDDMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX56</accession>
    <name>A0A010YX56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome bd-type quinol oxidase, subunit 1</fullName>
            <ecNumber evidence="13">1.10.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_0777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.10" evidence="13"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848504.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.764"/>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_11"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="457" mass="50044" checksum="20C723129EB5D1AD" modified="2014-06-11" version="1">MDQLDIARWQFGITTVYHFIFVPITIGLSVLVAILETAYVRTGKEHYKRATKFWGKLFLINFALGVATGIVQEFQFGMAWSDYSRYVGDIFGAPLAIEGLLAFFLESTFLGLWIFGWDKLPKAIHAACMWAASIGTVLSAYFILAANSWMQHPVGYRINAETGRAELVDFPAVLTNSTTLVTFPHVVLAAFMTGAALMIGVAAWHLARGRHADVMRPSLKLGAWFLLVASIGVVISGDAQAKIMTEQQPMKMAAAEALYDTVAPASFSVFTIGSLDGRDEVFSIRVPRLLSYLATGRWDGEVEGINDVQRDSEAAYGPGDYRPVVPVTYWSFRLMIGFGLLALAVSAALLVFLRRPRPWLWKVAVWAIPLPILANSFGWIFTEMGRQPWVVHGLLRTADGVSPNVPAATIATSLTVFTLLYGALAVVEFGLMAKYAKAGPDEAAAPDDAERPVAFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYD6</accession>
    <name>A0A010YYD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849029.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1269"/>
    <dbReference type="HOGENOM" id="CLU_002554_2_2_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458897" evidence="3">
        <location>
            <begin position="31"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="517"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="971" mass="103232" checksum="3DBEFC794EB21088" modified="2014-06-11" version="1">MKSRSRSVLAKLITLLALPFVSLVVLWAIAASATLGQGIDLLKINDEVSDVVDPLQELGRELRAERLESVIAVAAPERNAEALREQRARTDRALNRFRDRAVDGANTDAVRSRVTTFLDALDDLEDRRSAIDRRTLSRLAVVDYFTGALDLTLPIVTTIPHLPVSDFALRANATLELASAIETQSEEMAVLAGATAGGRFEADEYTRAVQLIGAQRHFYTDVLPQLEPVDQQAYRDVTGGSAARLITAAEDSVVRSGAGDAPPPIDADDWIDNSRALSGQMVDYSLEVSDRLFDDFIPTAAWVLIRIAVGGVLGLVAVIVSIVVALRIGRSLVRELVGVQRSAQSLATYELPAVVRRLRSGESVDVDAEVQPMTGFTIKEIEGVASAMDAARSTAVEVAIEEAQLRRGVREVFLNLARRSQALIHRQLTLLDAMERREKDPDELEDLFTLDHLATRMRRHAEDLIVLSGSTPGRGWRNPVPLIDVMRGAIAEVEDYARVRVVGSPRASLAGRGVSDVIHLLAELIENATSFSPPHTTVHVTGELVPAGFAIEIEDRGLGMPPEQLEAVNQRLAEPPEFDLLQSERLGLFVVGQLARRHDIRVVLRGSPFGGTTAIVLLPGAMIVAPEGAIPTQRREPMRAEALAAEAVELPVGPPVLTVAAEPGGAHRAPEEAVNGNAPVEPPPVFDPSVWSGGTDWSVLSDDTVLRPADELRAPAGSGPSAFAPSAFAPSDFTQADFTPAGPDPVEPARAEPAPVDAAPVDAAPVDAAPAEAGAGGLPPLTRRDPGVGWEHLTAQGPLPRRERLRPSAPDAPPARTESVEPDADDLGPDQADQRPRGVARAPIASRARPADEPADTSDPPSPEPTDPEPAVTTPGGLPRRVRQASLAAPLRAGSGIPPAPVEPTTMRSPEEIRAVMGSYQRGSVRGRSDAERTIAPESDPAGPAAQDSASEPDGVPAGQGSNTGALEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZG7</accession>
    <name>A0A010YZG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849566.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1663"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458951" evidence="2">
        <location>
            <begin position="32"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="79"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="37206" checksum="953AD098C58B0DE5" modified="2014-06-11" version="1">MVQFRRLGATTAAAVLLVSLGACTKTTPSTASAGEDADQQVRSTAGSGDGCTADKYNGGVPKRDLKAITVGFAQSEKEANPFRITETESIKAEAAKRGIKLITTNAQSDLNKEIADIQSMVAQGAQALIISPLNSEGLDPALKAAQDAKVPIMTIDRLLTTKQPCVDYIGWIGSDFVEQGKRAADALIAATDDRGETAILLGASGVNVTVDRTKGFKDQLAAKNSKLTVVAEQTADFTREKGRSVTEQLISANPKLAAIYAENDEMALGAIAALKAAGKKPGDVKIVTIDGTKGAVQGIVDGWISGVIESNPRFGPLAFQALEDFYSGKGVPPKTIIVDKEYTKDNASAELANAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZK3</accession>
    <name>A0A010YZK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849613.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549582_0_0_11"/>
    <dbReference type="OrthoDB" id="1841091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="474" mass="49872" checksum="5DF494E18DB3DE50" modified="2014-06-11" version="1">MRPLAVGIGLFALVGAVRSGWFAEGDTFWQIQTGTEIRHQRTVFLTDTFSWSVAGRAWHPNSWLFDVLLSLAWTGAGPVGLALFTLGCITLVGASVAVTARSLGARVHVTTALLVVPLLLWLSARPQTLTYALLPLVLLLAGRLLDRTGWERLAGLAGLYLLLTLWVNLHLAALAAIPAVAAGLTLALIAARRRSNPASMPTAAAIVVVVVLGCLTSPFGVDVLASALATRDASTALIPEWAPLWRTSWMAVFTWTGAAVAVGLALAAWRRRPSDPLLAVVAGASAMLLVAGVEAARFSPMALVVAMPAAAAWATGVDWNGGSGRRRVAFLARGTSIGLVVALVALTVVRLPEYGRPAPDSYPADTTVDAVPAGCRLLNEYDDGGYVILRRTADGVRVAMDGRNDVYGAALVADLLELAQGRPGALAELDRDGVRCLLLDPRRPLVTQARAAGWQEAAADDNRVLLLSPTSQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZR4</accession>
    <name>A0A010YZR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569942.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1748"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="365" mass="39248" checksum="5F684C8046FB44F2" modified="2014-06-11" version="1">MRWRSDLGLAVLSVVVGLFFLADEKPARPVVDVVVGLLAVAAMVVARRRWTIPIAIALIPLMTVSTLSMGPAAVALGVVARRCRWPATLAVVGLHLFLLVGAFTAIARHDPEYPVAIVAVVAIDAAVVASGKLVRSQRLLVESWQVRAREAEEGQRLRVDEARHAERERIAREMHDVLAHRISLLAVHAGALEVRKSAPEDERRAAGVIRESAYAALEDLREVIGMLRSDDADADRPQPTLADVPALVEQSREAGTEVTLERPEFTAAADGAGRHVYRVIQEGLTNARKHAPDVPVRVVLAERNGGLAVEITNPVGAANGAALPGAGSGLIGLRERMELLGGTLEHGRTRSGEFRLCAWVPERAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z065</accession>
    <name>A0A010Z065_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">CryarDRAFT_1938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849951.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1902"/>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_11"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="513" mass="53024" checksum="3A2424BB1BF926EE" modified="2014-06-11" version="1">MTRPTEAAVLTVSAASAVDAEVDAVVIGVHRDGEQLGLGPGAAAVDAALGGRLLDVLARLGANGVAGEVVKVATLGATTAPIVAAVGLGPVERKPGAPDPHENYRRAAGAAIRALTGTDRVGLALVDADPSLTRPVLEGATLGAYDFVGYKSELAPSYRPPVREIVLLADATGRGEIELQGETDRVKALTDAVRTARNWINTPPNDLRPPAFAAQAAEAAADAGLEVEVLDTDALKAGGYGGILAVGLGSEAGPQLVRIAYTPAAYDKHVALVGKGITFDTGGISIKPAQNMQDMKSDMSGAACVVAAMTAIARLRPAVKVTAYVPMAENMPSGSAYRPGDVVTMYGGKKVEVLNTDAEGRMILADAIVRAVEDEPDYLLETSTLTGGQVVSLGERISGLMGSTELLARIKDAGTRTGEPMWPMPLPDEVRSGMDSAIADVTQINAGFDRAGHMLQGGSFLSRFVPDEVEWAHIDIAGPSYNTKTPHGYTPKGATGVPLRTLVEVVEDIAKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0Z2</accession>
    <name>A0A010Z0Z2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2171"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="422" mass="44214" checksum="75CB4C734FA5E453" modified="2014-06-11" version="1">MTPPRYVAPLISGTTYRRGVHLLLGAVIALPYLVLARAVLTLGDDRATRPALLLTGVAAAAIAAAPAFLNGTRGLEIAAARSLLGVDLPDPVPGTRPELETRVRCALWFGLHLVLGAVIASLLLVAVPIAVLVLSQQFGVLDADQAGLSGAPVGRGAAAWLLFAVVVLVVTGYVTAGFGALAALMAPVLLGPSATEREQALEIAARRLAERHRLARDLHDSIGHALTLATVQASAAGQVFDDDPQFVRRALLVIEETSRTAMDDLDHVLGVLRDRDVRGDETDRDHDGGTRGPQPTLARLDRLCDDSLARGVPVEVTVTGAVTAVPAVVSREGYRIVQEALTNVARHAGRVPATLRVTVTDAELGIEVVNPLPERASAAGSRAGRGLDGMRERVALLRGTLSTGRSAVGWQVSARLPLAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z148</accession>
    <name>A0A010Z148_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850362.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_2_4_11"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11577" checksum="47679D6D817E366C" modified="2014-06-11" version="1">MTEYDVLLADCPARTALELISGTWMIVVLVGLAHGPQRYSDLRRRSGGITKKMLSQTLARAVDGGLVRRPDQRGGAYALSALGESLLVPVTALTTWAETHADELAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1S6</accession>
    <name>A0A010Z1S6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ORF">CryarDRAFT_2484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850677.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2447"/>
    <dbReference type="HOGENOM" id="CLU_006384_0_0_11"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="35271" checksum="9B724780B835A51E" modified="2014-06-11" version="1">MCVRAAIAGASGYAGGELLRLLLSHPHIELGALTAASSAGTTVGEHHPHLAPIADVVLQPTTLDVLQNHDVVFLALPHGHSGEIANVLPAETIVIDCGADFRLADPVAWKRWYQSDHAGTWPYGLPELPGARKQLEKATRIAVPGCYPTAASLALAPAYQAGLAEPDAVIVAASGTSGAGKSLKPHLLGAEVMGSLSAYGVGGAHRHTPEIIQNLSQAADEPVTVSFTPVLAPLPRGILATCSALAKPGVTLQKLREAYADAYREEPFVQLLPENRWPSTAATLGANTAQIQVALDEDAGRIVVVAAIDNLTKGTAGAAVQCLNLALGLPETTGLPMTGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1Y2</accession>
    <name>A0A010Z1Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570081.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774290_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15273" checksum="C6B552F3B6030D83" modified="2014-06-11" version="1">MGLDTIDHAPTETWSPPPPISWPPAPAPPRRRRPYLAAALGLVCGALVVGGAWFGTSLLNPPAPGPADDAAAACRILGDLPAFTAERVLRSESAELRTAGELSAAAAAGDERYRSLADATRRVYLSSTELDTTAANRQLVIARAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z346</accession>
    <name>A0A010Z346_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851283.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2915"/>
    <dbReference type="HOGENOM" id="CLU_082427_0_0_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24283" checksum="1E49B13148D688C0" modified="2014-06-11" version="1">MTGRDQIVEAAAKLLREQGVRAVTTRAVAEAADVQAPTIYRLFGDKEGLVDAVAEHVMATYVAEKVRQDVDDDPVADLRSGWHAQIRFGLANPGLYALLYARERSTPSPALAAGIEKLRGKIRALATAGLLRVDEDRAVWIIHSAGTGTVLTLLGQPADQRDEGLADAMFDAVAGRILSARPAAADDSLRTVAVTFGTRIGELPALTDAERTLMSEWLSRSLAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z384</accession>
    <name>A0A010Z384_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851335.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2954"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="19944" checksum="7771CA3C85FD535A" modified="2014-06-11" version="1">MTAAKPLRADARRNRDALLAKARELFADGCFDLRFDDFARLAGVGTGTLYRHFPTRAALAEAVYREELAAMCARAGELRATLPAAEALAAFLRGFVSHLHTHQGLARTLATLMASRSDALADGGRELDRTIADLLAAGVEEGTIRDDVGAGAVMMALQGICTACSEPGSRDDADGTVTLVVDGLRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4G5</accession>
    <name>A0A010Z4G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851919.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3362"/>
    <dbReference type="HOGENOM" id="CLU_027853_7_1_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="32521" checksum="C04526A7066ED639" modified="2014-06-11" version="1">MPLKLGLSLPQAIPYDLAKDVPAFAREAERIGYASLWVFERVLTPTDQSGAHGLYGFPDLPWPDLYQRTTDPFVTLAQAAAVTTRVALGTGVLVAPLHNPVQLAKSIASLDVASGGRLIAGLGSGWSIDEFDAVAPRPITERGAALDEFLDVAATVWAADPVSVEGTTFRLPPAYINPKPTGELPIFLGGISEPALRRIAKRGLGWLPTGLSPAQTTEMLSRLRDSAGAELPCITQVGYTSLAEVSSAERAPYAGSPAQLMEDLAELAAGGVEHVYLTLPYGFSDLKELIDAAEQVYGAAQEAGLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6R7</accession>
    <name>A0A010Z6R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853226.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2715604_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG83008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="72" mass="7534" checksum="73E46B2065A88D4B" modified="2014-06-11" version="1">MVTMRAGGLTVEVYLHADTADGRTEQRVKVKDRGYVVYDGTDLAAAQREAAALGLPWADLELVDEGGAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKK2</accession>
    <name>A0A010ZKK2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847665.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="185" mass="20195" checksum="BB8C288F3FC3A45F" modified="2014-06-11" version="1">MSVAVELHPEPISEEEYLARPYTGQREELIDGVLVVSPGPSRPHQRISFRLATILDQRVTADLEVQEAVNVRLASGRLIVPDLAVLTSVGADDVVAPAAEVVMMAEIFSPSTKQIDRLLKPGLAAEARIPYFWLVDPDGPTVTVHNLDNGSYREVASASGEKLLTVTEPFQVEFRPAELLASRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLK9</accession>
    <name>A0A010ZLK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848295.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1683640_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="156" mass="16402" checksum="CA1644B1E0499E9B" modified="2014-06-11" version="1">MSVMTPVLDGGVRPVRLRPSRRPAAATAPTTVREQKVAAPVRVRTTLAPTATERAWVVLAHLSGAVSSAAGPMVISRLVGERSTYVKEQALAAANFQLAFLAALAPMLLLGVLTFGFAALFLVPLVLAWLLTTVLAALSAAGGERYRYPVGLAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLT5</accession>
    <name>A0A010ZLT5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.646"/>
    <dbReference type="HOGENOM" id="CLU_000738_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="393"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1813"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1931"/>
            <end position="1962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="2094" mass="227204" checksum="BC49AD8E982D86CD" modified="2014-06-11" version="1">MTAVFPVAAATDRIESLRTRVSRFSDYLSAVRALSARPARTLEAAETVVWQAALPVGKPGCWIAGAESSAPVASASVDDVEDPDETGTGARADECWLELRRPPRPRPPDLPAVVRSLLDGPVDDPRREPALRDGWREIAAERDADLDLDAVEPAVDEWLQRLWRPWAVTAAEADAVRGAYSRLVELRQAAVRLEASHELVWGFGLFTGVIGDVPVEDPLLAAPVGIDVDPESGALTVVPTGELRLQTDAFEALPDGPDARLHDLAGPGGAVTLDPWEQSGRTEFYRSALRRLGLPPRVIREDAQIEEPHVRDTGVILLRPRRTALSGFLADLRASLAAGHVPSGALAALLADDPSTLDLPDDPPEQWQPIGERLLFPLPANLEQETIARRLARQRMVAVQGPPGTGKTHTIANLICHLVAHGRRVLVVSHRDEPLAEVRDKLPPALRPLAISVMGSSAKQLGQLETAVRQLQAEAGALDQDVAAEAVDELWAALDTAEQDLSAKYHALRAVADRESGTFLLDGVEATAVEVAEWLWANESRLAFVPDTIDPNTPFPLSDAELAELTELTNTYRPEDLVDAQRRLPERESLPDGNRLARADEHAEALRQRLGALASLGVDVATVRGAGRPVVAALADEIWRIAHRARSYQPWQLRLAGRLAVSPAWRETCQAEVAGCAEMLTETARWRSVLAGRAVQIPDELWADPRQLRADLDMLRIRLVEARGVSRLIHRRLAQVRDDIRVDGAPLRTVDDVDAALATVRLDWARRRLTERWNHFVAELDGPQAPDDPSTVEVISGYLREVGDVVDIGLRYWPTLRERLAVFLRAGSPGEADWADPNALAGAAGRAGELVAVFESDEAEREGIQVRALLDEALLDANASPLWRELDRSWAVGDYAAWEAALAGADRLRAAGPAMQRWQELHAGLSTIAPLWASRIALEGDLPDPAISQQAWNWRRADTWLRIVIGVEDTGALGRQADALRDRARELVGELATRSAWLAAALRMDDRARDALAGWASALRKVGKGSGRRAAGWTALAQQHMREAVSAVPVWVMSVERALQQFTGGTTPFDVVIVDEASQCGLLSMPVLSLGTRAVVVGDDRQIGPYAIGLAHDDVARLGQEHLGDLPSWPLFDVTTSLYDHAVRRSPEPLMLTEHFRCVPEIISFSSDQWYDGTVQPLRADRGRLDPVRVVRIPGTRERRDRYGEVNLAEADALVATISRLALDPDYAGLTFGVVSLLASSGQAQYINEQLVRHLGEQEMARRSLKVGDSYTFQGAERDVMFISLVVSDRDDHRAAFTGADHHRRVNVAASRAKDQMWVFHSVGPENLHPDDARGALLRYCAAPRLGLAALAAEPVPDETLYAACESELERSVLRELLNIGIRPAVQYPIGRHRVDFVIPTADGRRLAIECDHGRYRGAARWAEEMRRQAVLERVGGCVFWRVRGTLFARDPDAALAGLWPLMDELGLLPEEYREYLLGAESFAEPFAGEPEEPQPVHEVAESLEEWVEDDGWDENGEWVEEVPAEPVRAGATDLTVVLPFVRLPEDEAVSEEPAGPSEPAEDQWAGDAPTIVRLEDLTGEVPSPLNPWVGDAPTIPTIEDLPLDHPARRLLPGLMPRTSTEAPRPVSPAAHPVSGAPVEAYPVSPAAQEPYPVSATEEVYPVSPAAQEAYPAAPEAYPEAYPVSPAPVEPDQPVSPAYSAAQPVYPVSPAGAGPDEPVSPIYPVASVYPVSPAGEQPEQPVSPAEEPVAPPAPAAARLVPHPAQRARQLAQQAAAAPQAQPAAAASQAHQAAASQAQPEQPTPLEPQPQPEPHGRFEPHEQAEPDGRFEPPGQPEPYAPPQSEPQAQRGVYGVRVEEAPEARAQSGVPGLPTRRPVAVPPPEDLERFDPTAPAPHPAAVTPAAPQLPPQQIQPQPQAPQQQPPLMPPPSAQTQGVAQVAPTSPGGSPVSWWNDGPTTPAPTQFTEATRPLPLVTPPEPANYQEVGAIRADEARAALQAYRSGVDTPVQSGGKIVGWACFYPDDSIEAQRNRANVEVMRQEEALTETAGWLTNSEAAAIVAASEQRRDVPVVDPAYGEVGLVRFAADALTLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLW8</accession>
    <name>A0A010ZLW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848425.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.683"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="381" mass="42089" checksum="627DFD269BA176AD" modified="2014-06-11" version="1">MRRTLYEEDHEAFRSTARTFLAKEVVPFHDEWEKEGLVDRRIWTAAGAQGLLGTDVPEEYGGGGIKDFRYNAVLTDETIAVGASGVGFSLHNDVTAPYLTDLATDEQKQRWLPGFCSGELITAIAMTEPGAGSDLQGIATHARKDGTDFVLNGSKTFITNGIHADLVLVVARTDPDAKAAHGLSLLAVERGMPGFERGRNLDKIGMKAQDTAELFFDDVRVPKENVVGELNQGFIHLMTMLPQERLSIAVAAVAGARTVFDRTLEYVKDRKAFGRPVGSFQHNRFVLAEMATELELAETYLDKAVTEHNKGQYTAVDASMAKWWTTEMQKRVVDRCVQLHGGYGFMREYPVARAYTDTRITTIYGGTTEIMKEIVGRSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMI1</accession>
    <name>A0A010ZMI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848655.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.909"/>
    <dbReference type="HOGENOM" id="CLU_093791_0_0_11"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="27120" checksum="A57AA5A3C346848C" modified="2014-06-11" version="1">MTAQSVADAVTPPLAPGANLRWSVVRPTVARLKPATILELGCGGGGFGARLATMTPRYIAAEPDPVSYALASSRITPVGGTVINGDHTQLPAGETYDLVCAFEVLEHIEDDRGALAGWAPLVKPGGNILLSTPAGPERMGAWDEAVGHFRRYSAAQMTELLTEAGFVDVQVRLYGWPLGYILEGARNRIANRRQGKAVTEGAEESIEERTASSGRQLQPKGALAGNVVKLGTAPFIFVQRLAPTRGTALVAVGRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMT8</accession>
    <name>A0A010ZMT8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ORF">CryarDRAFT_1054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848757.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1035"/>
    <dbReference type="HOGENOM" id="CLU_071472_0_0_11"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="24367" checksum="C6DEFD0675AA0618" modified="2014-06-11" version="1">MDIVVKGRNVEVPDHYRQHVSEKLTRVERYDQKLIRIDVELFHEPNRRQAQTCQRVEITVKTRGPVIRSEACAADFYSALDLAMTKLENRLRRAADRRRVHHGRRTPVSVATAMADATSDIPAPMWAPQNGSEPHEDHAAHGSVAVLEDFEDGPCRIVRTKEHPNEPMTVDDALFEMELVGHDFYLFNDKDTGRPSVVYRRKGYDYGVMCLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN35</accession>
    <name>A0A010ZN35_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CryarDRAFT_1164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848884.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1142"/>
    <dbReference type="HOGENOM" id="CLU_036368_1_0_11"/>
    <dbReference type="OrthoDB" id="1755462at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG80099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="41625" checksum="F72E26C3683F1C46" modified="2014-06-11" version="1">MTHSTRALLTVTGADRPGVTAALFSALATLDLEVRDVEQVVIRGQLLLGVSVELPSADELPAVKRSVSDLGRALGVWIEVALAPTADAPMTRRLEKPHHVTVLGRPLTASAVASIASGISDLGGNIDAITRLSKYPVTSLELRVSGVESAPLRTALSAVAIAHHIDVAVERSGLARRAKRLVVFDVDSTLITGEVIEMLAAHAGPEAEAEVAAVTAAAMRGELDFADSLHQRVRALAGLDAIVLEKVRNEVKLTPGARTLVRTLKRMGFLCGIVSGGFTQVTDHLVDLLGLDYAAANTLEVIDGVLTGRVIGDIVDRPGKATALAKFAAAAGVPMAQTVAVGDGANDIDMISAAGLGIAFNAKPALREVADTALNQPYLDAVLFFLGVSREEIDEVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNG5</accession>
    <name>A0A010ZNG5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoglucanase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A010ZNG5"/>
    <dbReference type="HOGENOM" id="CLU_026963_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="SSF49590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="3">
        <location>
            <begin position="93"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="34330" checksum="26DC90A1B18E93F0" modified="2014-06-11" version="1">MSAGGEEGWLAVETTHKGKRRKGRGWLAWGLPTLIGAAVLISVTALVLGLKGLSDAACAAVLPQALSVPAAVPQPGDSRSGHTTFFDLAASGGSGCSYDGPPADGMYLALGFDEFANGAACGTYFNVTGPNGNTVRVQVVDSCAPCAPGHIDMSEKAFSQLADPEAGDVQVTYRAVANPSLPGSLKFKAQEVSEYYVAVLPINHGNQLTRVEINGGNGWQTGTRRGDGYYTADNAGSGPFQIRLTDIQGHTTTVSGVDLSGGSTTSTGVSMYSGSGGGRQTTTTKKSTKSPSTSATPKPSHTITLPPAIGATDAPTPSQPAVGRPETTNLADPKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNM3</accession>
    <name>A0A010ZNM3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation/cationic drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849082.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_0_3_11"/>
    <dbReference type="OrthoDB" id="1921902at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="10920" checksum="A4CBD625E34D08E1" modified="2014-06-11" version="1">MTYVFLAAAILMELGGTLALRMASVGRSAWYVAVVAGYLGAFVGLSLALDRGLHLGVGYGIWTASGVALAAVASKVLFKEPLTRVMLAGIALIATGVLLVELGASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP41</accession>
    <name>A0A010ZP41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">CryarDRAFT_1528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1502"/>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="460" mass="52470" checksum="F6FCED0FBC580A19" modified="2014-06-11" version="1">MSADRMDVIVNLSKRRGFVFPSSEIYGGLRASWDYGPLGVELKTNVKRQWWKTMVTGRDDVVGLDSCVILAPEVWKASGHVETFSDPLTECQSCHKRFRADHLEEAYEHKHGKPPANGLADVNCPNCGTKGAFTAPRQFSGLLKTFLGPVEDETGLAYLRPETAQGIFINYRNVEQTARKKPPFGIAQQGKSFRNEITPGNFIFRTREFEQMEMEFFVVPGSDEEWHQYWIDTRLQWYVDLGINKERLRLYEHPKDKLSHYSKRTVDIEYKFEFTGTEWGELEGIANRTDFDLNAHSKASGADLSYFDQEKGERWTPFVIEPAAGVDRTVLTFMLDAYAEDEAPNAKGVLEKRTVMKFDPRLAPVKAAVLPLSRNTDLSPKARDLAAKLRQHWNVDFDDAGAIGRRYRRQDEIGTPYCITVDFETLDDQAVTIRERDSRSQERVGLDAVEGYLAQRLIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP42</accession>
    <name>A0A010ZP42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG78997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530108_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG78997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="175" mass="18393" checksum="C51E2E6B10875896" modified="2014-06-11" version="1">MASELERIAGRLRFLSDQAQQHRQPVLDASRKLREAASTVHTARFDPPEDGPAITAPPHLAARLSQAADRAGRTVAPLSQTADLLRVFAARLASGGMSSAGGVPPDRPPGNPAGGPPPTSADVPSSPERGDREGTAAMPNGADSVAPSRYGRYPTTTTARRSPGNRSYEARRQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPL7</accession>
    <name>A0A010ZPL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA segregation ATPase, FtsK/SpoIIIE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847643.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.182"/>
    <dbReference type="HOGENOM" id="CLU_020567_1_0_11"/>
    <dbReference type="OrthoDB" id="374938at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="361"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="731" mass="79400" checksum="00065FC3752E6A41" modified="2014-06-11" version="1">MTSTTEQYGPDRPEDRYRVDGGAADVVDLSAARVRLAPDTQPDTAPDIRPDTVPDIADPVLEGEVLPPLPTPADEGWLPIIPVWMQSKTGIRNMVRLTLRRWWYRIRFTAVRLPWATVKWTGRAVRGSWRISGRLLAWALDTRADAMEQELATGARQDAKEFIRVREDRARRIRARLVVLGLATLVGAGGGAYLWFFTPRLVQVLVAMVLVTILARVGANPDTPLIGPAMATSSGYLQLSDAILMRALNAAGLGGTVAKVDRNGETTEEGNRPTLAQPLQRENAGYLAMVDLPFGKTVADATKGQAALASGLDVDEVQVFVENVRGSARRVSIYVADEDPFMLPPRRSPLARLPRVSVWNPNPLGADVRGREVCPSLIFNSFLIGAIPRSGKTYAGRALVAPGFLDPHCDVTVLDFKGGKDWQAAEQLAVTFRLGDDDEDLGYAIGALQNLKGEAQNRFKAFRAMSDEQNPEGKLTPELAKAGYRPHLIVLDEVQNLLRAPEKEIRDEALALLVWLAKTAPAAGFTLVMATQRPATDVIPSDLRDNTSVRLALRTKTWQSSDAILGSGINAIGFGTQRFLEEHKGAAILGGVSNGRGGDLQVIRTDLLKNSDFTQICQIGAQRRADAGTLRGHAVGQAEEIVVTVTILSDVVAVWPGVEPKVQAKTLVERLQEAYPSKHAHLDQTSLTKALKDHGVPVVQVYRDGSNRNGYALAAVRKALAKAEGPDITNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPW1</accession>
    <name>A0A010ZPW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.260"/>
    <dbReference type="HOGENOM" id="CLU_183720_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="50" mass="5705" checksum="2614307F0A9CCCA5" modified="2014-06-11" version="1">MTKWEYVTVPLLVHATKQILDNWGEDGWELVAVVPGPNAEQLVAYLKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ17</accession>
    <name>A0A010ZQ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847830.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846545_0_0_11"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="35427" checksum="6DE105FF6DB29548" modified="2014-06-11" version="1">MIDVYAPAEVPRCPDWTMSWDADPPGRAAFAVDDGEQTLLLAADGRRIRMVGAERLEDPGQLSPDGTRLALVVDRPVPTVSVLDLRDGSRRGFPATVRGAEVLSWLPSGRRLLYGNDEGMYLLDLETGRSDAYDLSGEEPREVAVAPEGARIAVDVGAYVRIAPLAGGPPVRVPLPEDAALGAHGWSPDGRLLAVGREITPSRDQRGGFDLVVTALDTERGFRPAAQVSVVGVVAGAFVGWRSMSSILLLERRFEEPFRLVVRGLDGSEIETLAHLHGSVWEVRAAAGLLEVVRTNADGEPVDLGVPPRWQRMTGAMKKGFRKDRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQC7</accession>
    <name>A0A010ZQC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569974.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1938"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24108" checksum="BD2DDA78EFBEC561" modified="2014-06-11" version="1">MTDNRSFPSPPGGEASGGVTTVLLVDDHDLIRQGLRHAFERDPGFEVVGEAGSVADALRKAAELKPDVVIMDLRLPDGSGLEATKALRSSRADIGIVVLTMYAGDDQLFGALEAGASAFVPKNAPADEVVASARHAASSPNAFTASDLASAMKRRLTPSGPHLSPRESQVLRLLADGMSVAGIAKQLYVSESTAKTHISKLYEKLGAGNRAQALMTALRLGLLEAPNTPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQJ0</accession>
    <name>A0A010ZQJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850074.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2004"/>
    <dbReference type="HOGENOM" id="CLU_048995_3_3_11"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16261" checksum="2DF54FF5C624D618" modified="2014-06-11" version="1">MTSRQYTTFEVADQLFGVDVAKVVEVLRFSEYTRVPLADKSVGGLINLRGQVMAAVDLRVRLGLEPRDMSKPSMNVIVSEEGEAISLLVDKIGDVVELQSDTFEPPPDTLAGPLRELIIGAFKLDSRLMLALDAKRAVDLGSSTAKAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQP5</accession>
    <name>A0A010ZQP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848269.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.565"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="36475" checksum="E130E8C2EAA42099" modified="2014-06-11" version="1">MEYVRLGRSGLRVSRLCLGTMNFGPETSEPDSHRIMDTAHDQGINFFDTANVYGRKTGEGVTEQIIGNWFASGGGRRERTVLATKVYGGMGDWPNQSKLSALHIRRACDESLKRLKTDYIDLYQMHHVDRDTPWDEIWEAMEVLRQQGKILYVGSSNFAGWHLAQAQEAAKARHFLGLVSEQSYYNLLNRWIELEVLPAARQYGIGVIPWSPLDGGLLSGAIRKQREGNGSRSSSERAAAGLEKHRTTLEAYEKLCADLGHDPAEVGLAWLLAQDGVTAPIVGPRTGEQLDSGLRAAELALDADTLGKLDELFPAPFPNPGKPAPEAYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR94</accession>
    <name>A0A010ZR94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2698425_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="73" mass="7758" checksum="8E882336B40F4587" modified="2014-06-11" version="1">MPEAAPALVDALMGASRVLTARVAVDRPDLVTNALDGLVAAAGELRDAEWWRRLEADQGRTSSATESPLLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRK5</accession>
    <name>A0A010ZRK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118224_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="18874" checksum="BCEFFC9FD5C33717" modified="2014-06-11" version="1">MSEYLAVVACGSPLAARVHEIAEAARKHGWVVRVVATASAMNWVDAEQVERVTGYAPLVEQRRPDEPKRFPTPGHVVVCPATFNSINKLATGIMDNYAAGLVCEALASGTPITIVPTVSDALWGHPAWEAHLARLTNAGVRFVDPGSGRVGDPRPTGDDVVAFNPEWAIPTGTAARNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRL5</accession>
    <name>A0A010ZRL5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1841794_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="14148" checksum="490963F909C36CCC" modified="2014-06-11" version="1">MSASGQDLGVQLYGLLVAAKNHLLEIAGQYGVALAALDASGYGASGAFSRPAELGGGFYGPVYQPLADLREELAQALTTTKENLGLTADALVLATQVYADSDAEAAAEFHRLLTDQAHGEPRPGDNGVVPPPGASGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRN3</accession>
    <name>A0A010ZRN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2435869_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="90" mass="9696" checksum="C710E20E1B9948BE" modified="2014-06-11" version="1">MRTASRLHQSAEPCPHCRGGLVGADQWDEWFAQRDDAESAWAAEHGSLDGFDLAELLDSAPDGEQEVDCTTCAGTGLRGRRAASRRSHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS25</accession>
    <name>A0A010ZS25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecA/RadA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1058"/>
    <dbReference type="HOGENOM" id="CLU_786907_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="352" mass="38317" checksum="E26B8337EE8ADCF0" modified="2014-06-11" version="1">MTTLNERLAAVQQELEAVEAENSQTEVVLEQDQVLYVDVAALLDGGLPEREKPTVLQRQDGNCLFYRRKVNVLFGDPEGGKTWVALAALVDVLTDGGKAVFIDLDHNGAGEILSRLIYLGAKPAELSDPERFRLAEPEDQLVMRATVADLCQWEPDAAVVDSVGELLPLMGASSNSPDDWTTVNRRILTPLANSGAAVIAVDHLPKSADARAAGPTGTVAKKRSINGASYRVYAMTAFAPGQGGAAGLEVEKDRPGGVREHCPMTGSQKQKAGVFRLEHRLDGAGHWYISDPVEVVREDVDADVQALDELVPPPRSKQDVKDRLKWGSDRAYRSLTRWRELRKEASASEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSD9</accession>
    <name>A0A010ZSD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850988.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2683"/>
    <dbReference type="HOGENOM" id="CLU_066193_0_0_11"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29371" checksum="7FC8E089DE3FCF4A" modified="2014-06-11" version="1">MIDEAVRGRPAPALRPYVAWYSGYRQAGIAPGRHRGLPSPYLTLIVTIDDPLVVAAHPDPAQPAEQYTTLVGGLHTVPALITHDGRQSGVQLALRPLGARALLGLPAGELGHLDVRGEDVLGPFAAELHERLRAASSWPARFAAVDAVFLKICRPANAPLPEITAAWRLLTGGGHTVAAAADAVGWSVRRLSDRFGTELGVSPKTAAKIARFDRARRLLLTTDRGLADVAVACGYYDQAHLARDFRDLAGAPPSQWLAEERRFVQAHDDDAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSH8</accession>
    <name>A0A010ZSH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851054.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2729"/>
    <dbReference type="HOGENOM" id="CLU_030571_3_3_11"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="30675" checksum="3B0FEBC905FAE109" modified="2014-06-11" version="1">MSHSIWILEYGYVDRFPASNLFAAQPNAGHRRMPYCFGLVRSQDRCVLVDTGFADPAISERLTAKYGDTRWAHPVDVLARVGVSADEVDTILLTHNHFDHAGCVDAFPGAHVWIQRREIDNYLAAVRRPARFEFLTRSCQADLPQQLATRPATLVDGVASPAPGIELRPAHDTHTAGSQVVVVDDTWVFAGDNVYSYENLEGLSGDGVLAPIAMTTGSAAGWLDFADAMLRGVGGDTRRVLPFHEAGVWDRFPSATWDDGLHVAEVSLAGGHVSVVPSGPGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT03</accession>
    <name>A0A010ZT03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849180.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150001_0_0_11"/>
    <dbReference type="OrthoDB" id="1936176at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="103" mass="10508" checksum="B46C0C5E51717DAF" modified="2014-06-11" version="1">MSVLETTLIFVLIPLAVAGVLALLTLGVGGGNRTPRYRPGMPFEFTPVWFLSAPPTGLSVNGQQPALERAAAPGVLQSGGVIDRAAPVTVANSGPKGGARGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT21</accession>
    <name>A0A010ZT21_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849204.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1404"/>
    <dbReference type="HOGENOM" id="CLU_106738_1_1_11"/>
    <dbReference type="OrthoDB" id="1736098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17604" checksum="07A6C02D5FA8A98E" modified="2014-06-11" version="1">MTETTTSFPSVTLADRAAILDTLHRYTAGLDLGDADLLASSLTEDATVDLGPAMRRIGYDFPPLRPRESVVSALIGAVGPLDTSHAISNVRSTVDGDVATVHAYAQAQHFEPGRGSDPAATRHALMMNRYTATMVRDGERWRIQHLDIANAWFDGDPTVLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT49</accession>
    <name>A0A010ZT49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2950"/>
    <dbReference type="HOGENOM" id="CLU_004665_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1058" mass="111294" checksum="E6A3E9EF8E746D48" modified="2014-06-11" version="1">MSPGAGNDRRPAAVREDQSVPPLRITLLGAFRVSRGADVVPVAGARLRSLLVRLALAGGHAVPPDTLIDAVWGEEPPSGAAAALQNLVSRLRRALRTPITVTPAGYRLAADRAETGGPIEGGPIEVDALRFELSAAAGRAHLRAGDPVAARAALAEAVTLWNDRPGAEPAVVAAAAPAVATRLAHLSIDVVTDLADVEIALGRPEEAAARLTGLLAERPAHEQAGALLIDALAAQGRRAEALTVYERLRTHLVDALGTDPGAALRERHARLLDVREQRPRRTLPASTTSFIGRDDDLVRIGDLLGRGRLVTVLGPGGAGKTRLALEAARRHPADGVRFADLSAVTEPAELTAAVLAGLGVRVGRRRSADDELDALVGELGAPGTLLLVDNCEHVIDAAAHLVAALLVRCPDLRVLATSREPLTVDGEMLVPLGPLALPSPDDRPGPALATAAVRLFAERAAAVRPGFRVDEVTRPDVVRVVRALDGLPLALELAAARLRTVSLADLAAGLSDRFGLLATGSRTAPPRHRTLSAVIAWSWDLLDEHERTAAERVSILPGGVTPASAAAVGAGPALLPTLVDRSLLQLVPETGRYRMLETIREYGTGRLRAAGELGVVSGRAAAYYTALMARQDALLRGPDQLAALRLVGAEYDNVLAALRHLCAAGDSAGAIELALHLTWYWQMSGRHSDAVHWLGEALAVPGGGPSPGRDRARAVYLFHRADVHSGLTADDRAEMPELAGRLSGDPDLPGHYRVIGPIMLFLHDEPAALASFQRLAGDDGWPAGLAHLFLAELAENAGALDEMLVHVDASLECFRRSGDRWSRAAVLLLRARSRRYDDLDGALADLREARAIADEFGGLSVGDQIHRDLLESDLYRRRGDADRAAALIRAAREHAPAPAVALLDAHEAALLLDLDRARELLADRPPVTGTTRALELRAAAALALARDDRTGAERALRDAVAAALATRELPLLASVTVTAAELAARRGQHRDSAVLLGVAARLRGAPDRTDPQVRSLTGRAESALGGPEFAAAYSEGRASGVEAVLARQELAGAAETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT95</accession>
    <name>A0A010ZT95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851412.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3008"/>
    <dbReference type="HOGENOM" id="CLU_017584_10_0_11"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="122" mass="14081" checksum="05E9EBA0D0BF8CC7" modified="2014-06-11" version="1">MFDDRSPIYRQIAEQIKADVLRGVLRADDQVMSTNQYAAHHRINPATAAKAFQQLVDEGVVYKRRGIGMFVSPDAAEKLRAERRERFFLDVVHPMVVEARMIDISLAEIRHHLEGLDDHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTC4</accession>
    <name>A0A010ZTC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570244.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_2_2_11"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="20974" checksum="4F5919152EBF2D07" modified="2014-06-11" version="1">MPEYVVDVVGSPWVYVILASVVLADGVFTALPSDSLLICLSALSVSGEPSLILLAVSAAAGAVAGDFVAYTLGRRAVGRFGVPRRGAAAVAFDGARRALGRRGGVAIVVGHFLPGGRTATTLAAGWLAFPRHRFGAASALAGTLWAIYLCGLGRIGGLAFADRPFLGAVPGIVFGVLVTVFLQVRARRAVVHGVGPGPCRQPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU20</accession>
    <name>A0A010ZU20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851816.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3297"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_11_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="503" mass="53759" checksum="7662AF732A6FCF52" modified="2014-06-11" version="1">MNRDLLRAADAGRVTYEVASTLLLTGGVTFWAVADPPHALAPWLLGLLTPVLWLLRLTRPTAAYVAAAVLGLGTGGESTLLLAVLSASFAYRAGTWRHLAAGLTVAWACWVGSGWWWGEDPDVVDGVFLSGMFLLTALLPAGIARFVRRQRALVATMHHRNEQLHGEQREIARRAQARERARIARDLHDSLGHKLTLISLYAAMPRSTDPPAETTARDQANLLRETSSAAMTELRQILGILRQDDDQPPVRPLTGLDELAANARGSGARVRFEQVGTARPLSSLTEHAAYRVIQEGLTNALRHAHGSEIVLTLRYEPDALVATVVNSAGRSLVGATSEQGLLGLAERVRVADGVLHHGPTAAGGFRLAATLPYPTPDGAAPPPAPGDFTEVMHRSRRRSRLVLAATAAGISGLLAFCVAGAWVSTALVSVDRSTYDAVRVGQPEDEVRSVLPNEKAGDPSVSGGAACVDYQASLVEQVRVGGGLVYRFCYRGGRLVDKQAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUF7</accession>
    <name>A0A010ZUF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035863723.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3433"/>
    <dbReference type="HOGENOM" id="CLU_069356_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="24590" checksum="1A99B173AEF53D18" modified="2014-06-11" version="1">MASGAQVIPTERTRDAERTRAEILDVATHEFAEHGYASARVDAIAGKTSTTKRMIYYYFGSKQGLYVAVLEHAYRRIRALEQRLDVDDLEPVDALRQLAELTFDHHETHQDFVRLVSIENIHHAEHLLSSEAREGLAAPALAVLTRIMQRGRAAGVFRSDLDALDVHMIISSYCIFRGANRYTFQAIFGRDLLDPDRRAHLRRLLGDLVVDHVTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUR6</accession>
    <name>A0A010ZUR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase, diketogulonate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570516.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3585"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_11"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="30458" checksum="15E7D991E0B2B886" modified="2014-06-11" version="1">MATDDRTRALADGNEIPLLALGVWQVPDGRECEDAVRWALELGYRHIDTAQAYGNERSVGRALRGSGLARDEVFLTTKFNPGLRDPEAEAQRSLERLGVESVDLYIVHWPQGGPTWAWDGMQRAHERGYARSIGVSNFSVSDLDAVRKVADVPPVVNQVQFSPFEFRRELWEACESRGVALEAYSPLGTGRHLDDPRVAEIAGRLGRTPAQVLIRWALQRELIVLPKSTHRERIEQNAQVFDFELGPDDVAALDALDRTQATDRALEHPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUV7</accession>
    <name>A0A010ZUV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="5" type="ORF">CryarDRAFT_2087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2052"/>
    <dbReference type="HOGENOM" id="CLU_112356_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="161" mass="17110" checksum="B2911083327F8920" modified="2014-06-11" version="1">MSPRTKSAKSSTDMATDMSLEASAQNAEAKAAAAGEQLPTIEFVSPMPGFPGHKSFVLVRLDEVGLLNSLRSVDDPELRFITIAPHQFFPEYAPEIDDETLAAMGTKDPSQLLVLLIVTAGDTPRDSTANLMAPIVVDPMTMKAAQCVLTGSNLPVRAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUX0</accession>
    <name>A0A010ZUX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850157.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2066"/>
    <dbReference type="HOGENOM" id="CLU_069565_0_0_11"/>
    <dbReference type="OrthoDB" id="1633344at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="33821" checksum="7E24118036D2C45F" modified="2014-06-11" version="1">MKFSVDAWDPGYGTSTEDDAARKKSSAQLDLEVERPQADWKPIEPRPVPAPSAVLFVDGVRRIDAQLWVHSENAASLAICASYAAGVVCCTDSGATVPTVQVRRGVFTAAEDAAPVSTSAGTYALYKVRRDDADALSLGVQSQLADVEMEAARRAREGLGEAASGTDLLVVDGPLKGRQHLPRALGFIKTHKAEYLPAHLNGVVARLEAAHRSPVFRMGTSWDRYAWYLRLPGAVGSPWAGVVRVECAAELTAADAVALANLSQETLCRYASVEFKDSRAPQNLFPIAGLERALRRRLGDPGLLYRALRTAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW38</accession>
    <name>A0A010ZW38_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850757.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2506"/>
    <dbReference type="HOGENOM" id="CLU_022256_1_0_11"/>
    <dbReference type="OrthoDB" id="1591714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="48611" checksum="6BBFBAE5561926DA" modified="2014-06-11" version="1">MKQIHLAAHFPGVNNTTVWSDPAAGSHIEFDSFVHLAQTAERAKFDFFFLAEGLRLREQGGRIYDLDVVGRPDTFTVLAALAAVTDRLGLTGTINSTFNEPYEVARQFASLDHLSAGRAGWNVVTSWDAFTGENFRRGGFLDQSDRYARAKEFLATAAELFDSWRGDEIVADKVSGAFLRDPAAGTFRHQGDQFDIHGRFNVPRSPQGRPVILQAGDSDEGREFAAATADAIFSRYGTLAEGQAFYSDVKGRLARYGRTPDQLVILPAATFTLGDTDADAQEKAAVIRRQQVSGQTALKFAEQLWNRDLSGYDPDGPLPDVDPVVGDSHISRGRASVRMFRDPLAVARQWRDLAAEKKLSLREVVIEVTGRQNFIGSASTIAEQINTLVQADASDGFILVPHITPGGLDEFADTVVPLLQERGVLRTEYEGTTLRDHLGLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW66</accession>
    <name>A0A010ZW66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class putative F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862045.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2534"/>
    <dbReference type="HOGENOM" id="CLU_123922_0_1_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15886" checksum="A8FEC9368BAD9E88" modified="2014-06-11" version="1">MSDDTGFDLHGLLASARLGVLATIKSDGRPQLSPVTPYYDRENDTIYVSMTEGRAKTVNLRRDPRASLEVTAEDGWAWATAEGTGTLVGPGTDPDGPEVEALVDYYRAAAGEHPDWDEYRSVMVSDRRVLLKLRVEKVYGAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWH4</accession>
    <name>A0A010ZWH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853273.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4199"/>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_11"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="159"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG83019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="706" mass="78913" checksum="9EB6829E1F1E2EA6" modified="2014-06-11" version="1">MSTIWPGSPYPLGATYDGGGTNFALFSEVAERVELCLFDEDGTETRVDLPEREALVWHGYLPRIVPGQRYGYRVHGPYDPGAGLRCNPNKLLLDPYAKAIDGEYTWGQELFSYDFGDPGSFNDADSAANAMRSVVINPFFDWANDRPLRIPYHESVIYETHVKGITERHPDIPEDVRGTYSGLAHPVMIDYFKKLGVTAVELMPVHQFVHDSGLLEKGLRNYWGYNTIGFFAPHNGYASFQGHGSQVQEFKSMVKALHRAGMEVILDVVYNHTAEGNHLGPTLSFRGIDNAAYYRLVDEDKQYYYDTTGTGNSLNVRHHESLRLIMDSLRYWVTEMHVDGFRFDLAASLAREFHSVDRLAAFFDLVNQDPIVSQVKLIAEPWDVGDGGYQVGGFPPLWTEWNGKYRDAVRDFWRGEPGTLGEFASRFAGSSDLYEIDGRRPIASINFVVAHDGFTLTDLVSYNEKHNDANGEDNNDGESHNRSWNTGVEGPTESPDVLALREQQKRNFLATLLLSQGVPMIAHGDELGRTQQGNNNVYCQDNELSWVDWESARDHEVLTRFASALIRLRADHPLFRRRRFFRGEPVGDSGVEDIAWLRPDGRPMEPSDWTAEGAQAIVVFLNGQGIPESDALGEAIVDDSFLLVFNPSGDAVECTLPEAEYGRAWEVVVDTADPLLLAPSETAGNLKAGGGVTIEPHSVAVLRCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWL4</accession>
    <name>A0A010ZWL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851005.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2692"/>
    <dbReference type="HOGENOM" id="CLU_023194_4_2_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="44346" checksum="0D513A5826C2561F" modified="2014-06-11" version="1">MNQVSLVVVGAGLRGQGYARRAVSSGGARIVAVAEPDPGRRERFAAEFGVAQVFEDWTGLAAAGRIADGAIIATPDQQHTGPAIALADLGYHLLAEKPMAPTEDEAERIVDAVERNKVIFALCHVLRYTAYTRGLMDVVGSGRIGEIMSIEHLEPVGWWHQAHSFVRGEWSNSRTSTPMLLAKACHDLDWMLYVVGRPVERVSSFGRLSHFRPSARPEGAAARCLDCPIEPTCPYSAKRLYFDCLGDPDKEFWPLSAVTSDHTVDGVTRALREGPYGRCVYDSDNDVVDHQVVSLEFEGGATGSFTMTAFSPFELRKTRLFGTHGYVEGDGVRLRVVDFRDGSETVVETGGSSVDADHTDGDHALVDTFVEAVATGDPTLLNSDATTSLAGHRVVWAAERARAAGTVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZP6</accession>
    <name>A0A010ZZP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852633.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3866"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_1_11"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33064" checksum="B56E19F95D58E131" modified="2014-06-11" version="1">MLRLLANRLALSIPLLFVVSVLVFGLASLVPGDAARTILGEQATPEAVAYLRNQLGLDQPWYERYGSWLAGVLHGDFGTSILSGQDVWTTLNTRLGVTLSLVLTALVVSTVIGVALGLVSAVRGGVLGRVVDVLSLIGLALPNFWIAIVLVSLFAVQFRLFPATGYVPLSASPSEWISSLAMPVAALSLLGIAIIGKQTRDSVLDTLDAEYVRVLRANGVSERRIIFVHVLRNAAIPIVTAMGVVAVGMVGGSVFIESVFVLPGLGSLATQSTLDHDLPVILGLGVYFTVLVIVVNVLVDVAYGFLNPKVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0I9</accession>
    <name>A0A011A0I9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853219.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4188"/>
    <dbReference type="HOGENOM" id="CLU_051050_1_0_11"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28240" checksum="C772CFF3594489C4" modified="2014-06-11" version="1">MRDVRVTHIGGPTALIEAAGWRILTDPTFDPPGRRYSFGWGTSSRKQTGPALDPDDLGTVDAVLLTHDHHADNLDDRGRAVLANVPTILTTRAGARRLGATARGLRPWDRTDLAAPGRATITVTATPCRHGPPLSRPVAGPVIGFALAWEGQEHGVLWVTGDTVLFEGVKQVPRRLTVDTMLLHLGAVRFPLTASLHYSMTATEAVALCALARPRTVIPVHYEGWSHFTQGRRAVEQAFATAPDGLADRLRWLPLGAAEPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAW6</accession>
    <name>A0A011AAW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569559.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.181"/>
    <dbReference type="HOGENOM" id="CLU_1076533_0_0_11"/>
    <dbReference type="OrthoDB" id="1892992at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="26623" checksum="C7F03F062A23292C" modified="2014-06-11" version="1">MSKFPTMGAGRGWAYVALVLGGGVSIAANVAHSFIPPAAPEGTADPVAWAAQWSPEPGAVLLSVVWPVFLFIAVEVLAKPSWPSGRWWRVLRFGGMLPVAAVAAIVSYRHLSGLLEHYGEDTVTVALGPLAVDGLMAMATGALIATAHRAAVVVAEATAAPADPVTVPEMPAPAPAIETGRAVSAAPAAVEATPPPRPRTPRKPDTATAVARLRAKNPEITQAEAAKRLGVTDRTIRRYWNPAPVEPASDPAAAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAZ2</accession>
    <name>A0A011AAZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847680.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.201"/>
    <dbReference type="HOGENOM" id="CLU_1011036_0_0_11"/>
    <dbReference type="OrthoDB" id="1762272at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="28504" checksum="01FA3A758FAAAD9B" modified="2014-06-11" version="1">MTSAFAASLRYEFRMQVRKRSVWIVPALTLVLFVLIGGSLLRDLFDPAERPPEARTAVVGLAVQLHGLLSIGFGCLLADRLVRDDRLRVASILDATPAEPRARLLGKYLRAGAATAVPILVAYLGFAIAYAADSGGAGAIGWALVAFAVVFVPGLLFVAALALAGPLVVPAPLFRVLFVGYWLWGNVVPPDTMPTLSGTLVHPLGGYALTALLDFRGIDGQDTLAGPVSGATLNFLRPDPTPAVAVLSIGVLLALAVAVLAGGHALRVRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB25</accession>
    <name>A0A011AB25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.226"/>
    <dbReference type="HOGENOM" id="CLU_085376_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="21906" checksum="FE0AF42604E9C528" modified="2014-06-11" version="1">MNATGAFVKTNDQTDGANPVTDNTRRGAPLDVIAASLRRERARARMSLSEVAKQAGIAKSTLSQLESGSGNPSVETLWALSVALDVPFSRLVEPAIPKVQVIRAGEGPTIYSEHAEYVATLLASCPPNARRDIYLVSAEPGRPRASEPHLPGTVEHVVICTGRALVGLSDDPVELGPGDYVKYPGDVAHVFEALEAGTRAVLLSENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABP4</accession>
    <name>A0A011ABP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore synthetase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848098.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.466"/>
    <dbReference type="HOGENOM" id="CLU_018524_1_1_11"/>
    <dbReference type="OrthoDB" id="856726at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="125"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="379"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="557" mass="61300" checksum="63AF1317E1E45A95" modified="2014-06-11" version="1">MNSSAWREAGLVLLTRAIAELSYEDMLRPEPLGDRRYRLDCGGVKYTFTADRSAFDSWRIDADSIRRDGEPAADPMEFLVDARRVLGLDGPTTAEALRELVATWSADALLRRNLPTARELADASYVDLEAAQAGHPAMVLNKGRLGFTASDAEAYAPEAGQTFRLTWIAVHPSLATAHGVPVDDELDPGTRSAFDAPDGYVWLPVHPFHLDACVRTLFAPYLADGRIVILGEAPDRYRALASVRTLVNVDNPEKRNVKVPLLIRNTLVWRGLPAGPTAGAPAVSAWLHTLRASDPYLDEHVDLLGEVASVAVRHPLFDRVPDAPYRYHELLAAVWREPVQTYLKPGERARSLASLLVTGSDGVPLTTELTNRSGLSAREWLRRLVDAVLAAPLHALHAHDLAFCPHGENTVVVFDSDDVPVRTMLKDFAEDVNLLPGRVYPGLPEEADRLLPRWSEGELAHSIVTAVFAGVFRPLAALVDVPDFWAVVRASVDAYFADRPELAERREAYGLTAAEVERICLNREQLTGGGFHDRAEKEEFEIVHGTVANPLVREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABZ6</accession>
    <name>A0A011ABZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014588_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29673" checksum="2998F5A81CA4559D" modified="2014-06-11" version="1">MEPTPAEVARTLAAGHLPARIRTSGEPAGGSPVPEFAVTHVTDRMGRVLLLLAEDSPVDRALRPVAADGDAVAQLTVADRQPVAGSPWRGRITMSGWATRLAGIAAHRAAMDFAEVNPIGELLDIGRGSVLYRLDLAEIEWVTPGYDAEDTGPDGLRRTDVDVDAFLDAEPDPFAPEEQKLLHDLADHHEDLLAELCAQARETAVPGASNARALRLDRYGLTLGVEVAGEERWIRAGFRHPIGDLKELAEVFHLLACCRCRPESHQHSPETHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC67</accession>
    <name>A0A011AC67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848399.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.663"/>
    <dbReference type="HOGENOM" id="CLU_044190_0_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="320" mass="34838" checksum="24D50DAA2B3D5536" modified="2014-06-11" version="1">MLDELDRQIVHALEVDGRAAFSRIGQVLGVSDQTVARRYRRLRAEENVRIIGNLNTWRIGAVSWYLRVQCTPDAALSIAEALARRSDTAWVRLTSGGTEISCVTRSRSRADTDALLLGKLHRTPRIVGISAHALIHMYFGGTESFLRKVQVLEEDQVTALLPPWAGDPYEEVPDIGPGDRALVTALARDGRTGLPELASATGWSETRVRRRLTELRRSGALFFEVDVPGSALGLEMAAMMWLSVAPHGMVEAAETLAGHPEVPFVAATTGSTNLVASVVCRDVAALYGYLTSKVAAIPAINHIETNPIVRTLKREGTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADE4</accession>
    <name>A0A011ADE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848861.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1117"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="30130" checksum="2D7E6261DC1DC4D2" modified="2014-06-11" version="1">MSWRQIRPVALPIVGLLVAVVFLAPYIVMLLDSLRPGSEALASPPTFLPQHWQLDAYGEILGDSRFQNWLKTSLLVSLASTVIVILVAIPAAYFSARFKFPGKTAFLFLVLVTQMFAPTSLVVGIYREFFELSMVNTYGALILTNSAFNLAFAVWILHGFFAALPRELEEAAELDGNGRLGTMLRVMLPLTLPGVVTATIFTFIAVWNEYVVALTLMQDDDKKPLTVGISSYVTGYDQNWDQLFAASIVAIVPVVVLFAVIEKHLVGGLTAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF36</accession>
    <name>A0A011AF36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849628.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1700"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="28442" checksum="4A8AF59246754202" modified="2014-06-11" version="1">MRPVSAAETAPTLVPWLVRAESLRVRAGKHLAVDGLDLTLDTGVHGLLGPNGAGKTTLMRALATVVKPAGGTLTLLGASVDGRADLREVRRGLGYLPQQFGFYPRFTVREFVEYMAWLKEMPKAAIPDAVQRSIDRVGLTAKADAKMKTLSGGMLRRAGIAQAIVNEPQLLLLDEPTVGLDPEQRLDFRDLLRDLGRDSCVLVSTHLVEDVVAACTDVILMNEGRLLFQGSPDDLVARGGPNDAGDSPAERGYSALLRQHRSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFH9</accession>
    <name>A0A011AFH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autoinducer 2-binding protein LsrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849816.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1813"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015762">
        <property type="term" value="P:rhamnose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030159">
        <property type="entry name" value="LsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013459">
        <property type="entry name" value="RhaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46847:SF4">
        <property type="entry name" value="PTHR46847:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02637">
        <property type="entry name" value="RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459469" description="Autoinducer 2-binding protein LsrB" evidence="8">
        <location>
            <begin position="25"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="9">
        <location>
            <begin position="59"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="357" mass="37724" checksum="DF89FC189784849D" modified="2014-06-11" version="1">MMLLRARRSVAFSAALVAVTLAAAACGGTTKDSTDNASAGPASSASANPDAPLKEGLKIAFLPKQVNNPYFTVSDKGGEKAVTEFKGTYKEVGPSDASASSQVQYINTLTQQGQDGICVSANDANAIVPALTQARQRGVKVVTFDSDAAVAGRDAFVNQADPEALGRTEVQLLAKQIGEKGKIAILSATPNATNQNAWIEFMKDELKKYPGMQLVKVAYGNDDDQKSFQETQGLLQAYPDLKGIISPTTVGIAAAARYLSSSPYKGKVQLTGLGTPNQMRQYVKDGTVKEFELWDPAKLGYLCAYTAAALASGQITGAEGEKFKAGELGEYTLGKDGAILLGPPQVFDTKNIDQFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG06</accession>
    <name>A0A011AG06_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2016"/>
    <dbReference type="HOGENOM" id="CLU_307115_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="963" mass="96855" checksum="60FE749202AC2266" modified="2014-06-11" version="1">MSTRLLLEGPDLESLLAKIKEEHGSAARIVSAERVRSGGLAGFFAKQRFEIAVDILDPEESPDESEDLDAPTADGLTALLARAEAQDSVERPVARPGNAARFAEVLAERSGDAARRTIEPAGGVGAGATRFGVFDGLADTAAAGPLPGATDDSARGGAGAQGSTATGQGVGERGAGVAGRGSAGTGINGPAAAGRGGAGTGTTGPAAAGRGGAGTGITGPEAGPEAAGRGAAGRGAAGHGAAGHGAAGHGTAGHGTAGKPGSSGGPVLNGPSVAAKLAERARRRAAELAAEAAENEQRTASRRNGRIRIVSGPGAADSMPGEDAGSDDDASVATESPADIARPRATSPAPGTRRDGTEPDEDAEPHDEADRSRGADRFTDAQHHDNTQHHDNTQHHDSTQRHDTSEHDEPSGRLVGARRRGRSEAEEPEHHEEPGHRGEPEHRSGTGRRGSVERSPGRRDGRAGPGSPSSDRIDEDEDGAVTAEVLIARPQPRRRTVRGAHPVSPAPRRSAPAAAEWGTSAVQRTDVATPGHPVLAADDQRPATGRASVPAHPGPTGPHASTGPHAPTGPHAPTGPHAPTGPHTPGTPVAPGLPPEIDGPPTAVQPMRRLPPKPTARNGYDHPAVQLVRNGVPVHIAARAVGPDPWTAVARAVAGLPYPPALPSRPGEVLVIVGDAEPALVVAGQIAALSAGIDPSATLVAGSIAGTGLRRSHRISGPEEAVRRAAELHSSAGPRIVVVEATAGSPIGRPAAVTPGADGSPRATIAALAPTQVWACVDATRKNADTARFLDALDRVDALAVHGADETVEPGSVLHFGLPVVMLDGRPATARRWTTLLCERLTGGPLPGDGPIAPIMPLELPAGHRGAHAAVTEEPVGSRRTTHRAPDAGYRPPAPVDYPPAPGAGLNGPGLNGRGGNGRGGNGRGGNGRSGNGRGGNGHGTPGPAANGHPSPVWWPEDEPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG33</accession>
    <name>A0A011AG33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase with GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="393" mass="42454" checksum="B7C7BFB8CA496A4F" modified="2014-06-11" version="1">MMVIRVLAASMGGMDLRAEPDFDSIAHLAAEICGAPIGLVTLVDGEQLWFKARVGCALTHTELDSSFCRWALDVPDLLEVPDALADPRFADNPMVAGEPYVRFYAGAPLRVGDDRALGTVCVLDHRPRRLTEAQQRALRALARHATAEVELRRYAREASGAAGRARDLEALEERILTTVGHELRTPLSSIRGYLEILLDDTEPLDPATARQFLGVMQRNSERLLRLVDDMLTAAEFSNGGISLRLADVDLTELVASVVEQSRPLTDHSAVRLLWEAPGTVRVTAARRPLEQALRHLLLNAIRFTSAGEIRVRVEPSIPAVLVSDTGTGIAAEDLPRLFDPFYRSAAAEADAVQGAGLGLTVVRAIVEAHGGAVAIDSTPDVGTTVRLTLNAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGJ0</accession>
    <name>A0A011AGJ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570023.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_5_0_11"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27061" checksum="554AE11AAE95A36A" modified="2014-06-11" version="1">MASDYAAMARFYDVLKAGDNYDAWAAALAEQIEARGTGGNRLLDVGCGTGVSSAAFQQQGYDVTGCDLAPEMIDVARAKDLPVEFVVADMRLLPAELGEFDVVTWIDDVANHLLGPDDLVTALRSSRERLRPGGVLVIDTNSRSTFGALFGGAIVVEHPDSFFTLLGRPADAGTDGPAQLRVVGFVRDGTAWTRSEAVVHERYYSGDEIADALRRAGFELAVALGWSRRDARLVAPASEDEHVKIVYVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGS0</accession>
    <name>A0A011AGS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850408.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2264"/>
    <dbReference type="HOGENOM" id="CLU_028808_4_3_11"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="28140" checksum="D72A64431747268A" modified="2014-06-11" version="1">MTSSLLEPFTVPFVVRALVGGVLLAAVCALVGVWVIARGMTFLGEAMSHGMLPGVAIASVLGGSLVAGAAASALAMAIGVNALRHSREFGRDTSIGLLFVGMLSVGVIVVSHSRSFATDLTAFLFGDVLAIRSADLVLLAGAALVVAAVSALAYRPFLALTFDPRKARTLGLRPGLANAVMLVLLTITMAVAFSVVGTLLAFGLLIAPSAAALLIARRLPAVMATAFLLGSAAVLIGLWISWFAATAAGATIAAVAVALFFVVLTVRRVVSATKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHF0</accession>
    <name>A0A011AHF0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2521"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="403"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="48658" checksum="4ADFEA62BE25432C" modified="2014-06-11" version="1">MHHLPQDFVWGVATAAYQIEGAVDVDGRSPSIWDTFGRVPGAIANGDTGDVACDHYHRWPEDLGLIRELGVDAYRFSVAWPRVIPTGTGAVNAKGLAFYDRLVDELLAAGIRPFVTLYHWDLPQVLQDKGGWPARHTAEAFADYAAVVAGALGDRVTDWTTVNEPLCVAWIGHLEGTMAPGLRDLHRAIDASHHVLLGHGLATQAIRAAASARADVGIVLNPSPADAATDRPEDAAAAVRADGHTNRWWLDPLYGRGYPRDMVETYGYEPPVLDGDLETIATPTDYLGVNYYFRAVVADDPSGPAPYAKQVEVSGRHTAMGWEVNPGGLARILTRIAADYAPERIFVTEQGSAWPDVVEPDGSIADKDRIDYLEQHLEAINAAVDAGVPLAGYFVWSLLDNLEWAYGYDKRFGLVHVDYATQQRTMKASGRRYAEIVREHRAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHQ2</accession>
    <name>A0A011AHQ2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">CryarDRAFT_2667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850914.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2629"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_11"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="39615" checksum="35BF91DDF353EE91" modified="2014-06-11" version="1">MDLYEYQARDLFEAHEVPVLPGVVVTTPEAARAAAAELGCSVVIKAQVKTGGRGKAGGVKLAADADEARAKADDILGMDIKGHRVNRVLVTTATDIADEYYFSYLLDRTNRTFLAMASLEGGVEIEETAATNPEALVRVPIDPLTGVDSAKAREIVAAVGLPEQAAEAVESLWSAFVAEDALLVEVNPLVRDAGGAIVALDGKVTLDDNAGIRHVAHAGLRDHDSADPLEARAHAKDLNYVRLDGRVGVIGNGAGLVMSTLDVVALAGARPANFLDIGGGASAEVMANGLEIVLADPAVRSVLVNVFGGITACDAVADGIVRAFALLASRGEPVDRPVVVRLDGNRADEGRRILGAAGLPGLELVDTMDGAAARAAELAGREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI52</accession>
    <name>A0A011AI52_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851095.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2757"/>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_11"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="50"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="542" mass="58756" checksum="27BAE2FC543F52BB" modified="2014-06-11" version="1">MDAVTAPPAPTNEPNLTYAPGSPERDALQAEIARLEKERHELRGYVGGDWVSGGGVEIDVVQPHDHQHVLGTLRNSTRDDARAAVRAAADAAPGWREMDFDDRAAVLLKAADLLAGPWRQRLNAATVLGQSKTPFQAEIDAACELIDFWRYNVHYARQILADQPIANSPGVWNRTDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNTVLWKPSPTQQLAASLTMELLTEAGLPPGVINMLPGDGLEVSEVALASPDLAGIHFTGSTPTFQHLWREVGANIANYRSYPRVVGETGGKDFVVAHPSADPDVLRTALIRGAFEYQGQKCSAASRAYVPRSVWAKMKDSFLAEIESIAIGDPTDFTNYLGAVIDARAFAKHRAAIERAKQSSGLDVLVGGVLDDSVGYFVHPTVIEGGDPTDEMFTTEYFGPILAVHVYDDANFEQVVRGMESIAPYALTGSIIAQDRRAIAWAQKELRFAAGNFYINDKPTGAVVGQQPFGGGRASGTNDKAGAAANLTRWTSPRSLKETFVPPTDYRYPYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIN2</accession>
    <name>A0A011AIN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007290_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="31101" checksum="C62E55F8AC1B3767" modified="2014-06-11" version="1">MTEHYVEYCEINREHPLRQGDILEATAAAALPWNRHLFVVTADCDFAHTKHQGRVTCIPLLRAEEYLLLLQVPKMRERLIKGPLKDLRAVFDTVGRTSISDRRAREWASEQSTAAIVTTLGLDGQESARAQSAIDAIRLMDAPVESLRAAVATLVEAQVLEAGQSKRDKVARSIISELRQVYKSPPGDALFLGAIAPAHEDGYFAYLRHIEQIWEPQIVLSAARQQASYRRISHLKDKFTHALVQRFALVFMSIGLPDEYEEMRDFHSVVLGDSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ16</accession>
    <name>A0A011AJ16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851526.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084997_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="30566" checksum="8E2F9DB9EFD343BD" modified="2014-06-11" version="1">MSRLDPNTVRAVAEIICDIEGPYERAGWQLARFFRHANWEQPPDYDGSPKVSWVVGCLEGRADDPAAIDRALCRLCDPREYPGDPDAAGTIRDALNKCLALDGLKVGYEGGRPRVFEITPRLVAAAETAPVVLTAELDLLVDDPIKRRVLNDRLSEAATCREYGSPIAAIVMLGSVLEGLLYEVIAARDPDGLDRLCPRRRDGTPGEPSLAQLISHAHRKGWLQKDAQEFSGRLRGFRNYVHARQQWANNDWPDGDTVQICWDVTIAALNDLGASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ89</accession>
    <name>A0A011AJ89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851662.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3186"/>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="325"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="645" mass="68586" checksum="3C55DA96074B74C7" modified="2014-06-11" version="1">MNRAELLSAYRRMRLIRVTEERVAVLYAQGQVPGFVHTSVGQEAVAVGALFRVRPTDVITSTHRGHGHVLAKGLPPERMFAELMGKDAGANRGRGGSMHVADPELGIFGANGIVGAGLPIATGAAYALRPRGDVAIAFFGDGAVSTGAFHESLNLAALWQLPVVYVCENNGFSEFSRTGDQHPVPVAQRAVAYGMPFQQVDGNDVEAVDAVMDAALAAVRSGGGPRLVEAVTLRVRGHYEGDPQRYRGAADLPADPLVVARERLLASGVPRPEIDEIDDEIARVVASAEKFAVDAPEPDPATAREFVTAPRRFVAVTDPGAGTPVSTSRIIRQALSDALTDDPTVFLAGIDVAGGNVFGLTRGLAEQWPDRVLDTPIAETAIMGLGVGAAMAGLRPVVELMYLDFLGVCLDQLMNQAAKLRFMTGGAVTVPMVVRTQFGSGRSSGSQHSQSLEALLAHLPGLTVVMPSDPADHYGLLRSAIDDDNPVVFIENRLIYERKGPLPARGYRVPLGSARVVRPGTDLTIVSWSRMVHLSLAAAAQLASEGVDAEVVDLRTITPLDRDAVLRSLARTNRLLIVHEAVTDFGVGAELAALAVNEGFWSLDAPVRRVGAPATPAPYAPALERTWIPTENDIIRAARELTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJE8</accession>
    <name>A0A011AJE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3240"/>
    <dbReference type="HOGENOM" id="CLU_222687_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1368"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3041"/>
            <end position="3116"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4509"/>
            <end position="4584"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="6198"/>
            <end position="6276"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="7826"/>
            <end position="7901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2627"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1403"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3076"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="4544"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="6236"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="7861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="8615" mass="892271" checksum="23C0B3B4F29B7F0D" modified="2014-06-11" version="1">[encoded data, 8615 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKB9</accession>
    <name>A0A011AKB9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852202.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3560"/>
    <dbReference type="HOGENOM" id="CLU_040078_1_1_11"/>
    <dbReference type="OrthoDB" id="942354at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="148"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="27263" checksum="33A93E3D5DB2268C" modified="2014-06-11" version="1">MSPATAGDWAGRPLGDRTVRWTERDAILYALAVGARPDQLDLVYEKHLRVLPPFALTLAQWAPDALGSAGAFDVGTTLHGAQRLTVLEPLPPAGELTLAARVGDVWDKGSAAIFDVVVESRCFVATWTLFAPGRGGFGGERGPGRPAPPDTPPTSTAAVSIAPNVAVLYRLLGDTHAIHVDPEAAAGIGQPRPILHGLATLAIASVALAEEVGAHPADLSELSGRFAAPVFPGETVTVRGYAGGAFDVLSERGAAVDGGTVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALQ6</accession>
    <name>A0A011ALQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852884.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4042"/>
    <dbReference type="HOGENOM" id="CLU_033218_0_0_11"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="218"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="57549" checksum="E438BCBD0915CCCE" modified="2014-06-11" version="1">MKVLGCNAGKVRTQRIDGEEVRTAYLKSPVAAPWTITAAGADGDEVAVHTNHLYAIDRESYGHWGYASAEDGLFAENLTLDVLDQSALRVGDRFRVGTAVVVVTGPRIPCWKLTWRLGRPKTFMREFRLSGRSGAYFNVVSPGVVEPGDPLVPVSGDPGAPTVAELSRLCDSGTAITAADREVIDRALACPDLSDGVRGTLTLKMANLARDAAADGWRGWRRFTVDEVVPETPDVNSYVLRPVDAGALPGFRAGQHVVVRVGDVVRTWSLSAYGTDHYRITVKRRGAGSTALAAASTVDLRSPAGRFHLDRGSFRPVVLVASGIGITPMIAMIQAHLDRNGFVPPLWLLYRTRAERTAFGAYLDQLFARHEHLHLRYFHAPLTAERVVEVMRGNYLPGAGDVPWFESDVYVCGSLAFTTEVRDGLIALGANPDLVFAEDFVAAASPPAGPRRRTDAIVRFGGHEVRWPADREQTLLELAEAAGLDRPSDCRAGTCRTCEARVLEGAVDGPVVGDRALLCVSYPLTERVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALW8</accession>
    <name>A0A011ALW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4124"/>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="158"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="494"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="698" mass="71012" checksum="9D650A7274036E1D" modified="2014-06-11" version="1">MTAAWVVLVVLFGVGAATMSGPSEEGFSIPGTESSRAMDVISAKMNTGSGDTASANVVFTAGDLAGAGPRTAIEGALTELRALPDVAAVSDLVVAEDRRTAYATVAYDVPVTDLADDAREQLIDAGRSAEPAGIGVEFSGSAAQEAGETPAGEVLGVLVAALVLVLTFSSLVAAGLPLLTALIGVGLGMLGIRIATGFFDLSATTSTLALMLGLAVGIDYALFVLSRYRHELRRGRSGEDAAGHAIGTAGSAVVFAGLTVVIALAALSVVGISFLTSMGLAAAGTVAVAVLISLTLLPALLGFAGNRVLPRRARTGRPPAGPEGRRPLGERWARSVVTHRVGVVLAATGLLVLTALPALDLRLALPDEGTAPVGTTQRTAYDQLSEGFGAGFNGPLVVLVEAEPGRAAAAADQAGATLRGLDDVVAVTPPTVNPAGDTALLTVVPGSGPSAAETTALVETIRAQPDPPGATLAVTGPTALGIDVSDKLTDALVPYLTVVVGLAFLLLMLVFRSLAVPLKATVGFLLSIAATFGATVAVFQWGWLAGLLGVDTTAPIVSIMPIFLIGILFGLAMDYEVFLVTRAREEFVHGATPDAAVISGVSHGARVVSAAAIIMICVFAGFVLSDEPIIKSLGFALAFGVAVDAFVVRMTIVPAVLSLLGRAAWWLPRPLDRWLPNVDVEGARLTVAEEPSPVAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGC2</accession>
    <name>A0A010YGC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847798.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.282"/>
    <dbReference type="HOGENOM" id="CLU_2878333_0_0_11"/>
    <dbReference type="OrthoDB" id="311112at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="63" mass="6917" checksum="2CEE7A11CDD56867" modified="2014-06-11" version="1">MASKKDQLQSYQFLVQRFVSALVMRETDPAQMPFRRLAGAAFASVMVAVLALAGVGIYSLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGY6</accession>
    <name>A0A010YGY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569648.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.563"/>
    <dbReference type="HOGENOM" id="CLU_021151_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="535" mass="55377" checksum="E5A335CCF4B69ECA" modified="2014-06-11" version="1">MRPLRFVALSADGQAMILTDEVGRMLSLAIDDQVIAAVQRERTGTPGQLSMDVEATLTPRDIQSRIRSGESAEHVARLANVPMEKVLRFAGPVLQERAAMAQLARRTRLRGAESGQTLADVVDARLRAHGIDVETVAWDSYRREDGGWRTTATWPSGKATAHAIWDLDRARSMVSPVDEMANFLSSEKQEDLLVGPDEQMLAFGVQPGKLPEDADPKEGPVVPALSMLRRRDERRREEPVAVASAEAVAAPAREVPRELPREGRGDLRQAARDSGRGRALDPRFDDFRRSEPSREHAPTPNPEPPAADAGSGPAAAATAPTIGGTAPGLGGGAVQPGAPGHGAPGHGGAPGPGGTPGQGGTPGHGAPGHAPGLGGRDGLGGRDGLGGRTGLGGRGGLGGRDGLGGDGRGAVASPGSADGPISGGRSAGWLDEPRPAGGARPDEVRRPDPWGDDPRRPAGRRGDVSTGDATPTSGGGFAGRNDWRERLDPTGVGTPPTASPARPEPQPPKAGSGRGRKAELPSWDDILFGSGARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHZ1</accession>
    <name>A0A010YHZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.936"/>
    <dbReference type="HOGENOM" id="CLU_896632_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="33194" checksum="691089CAD8453CE9" modified="2014-06-11" version="1">MFGEVHTELLWHSASVSNASAKRILSFRLGDDIRSSTRPTSFAISPDLYDGLDCRIGGGARHRAVGTAASFASITGGQIAQAVTMTSIVHGENNRRMPWSYYLSRPGQVETIGSEPDWENLAGGWVSADKAGPNLGAISDRLLDTVQMSPQLSGTAAVRRTGRARLRWSYARSSEPVRLTYSLESEDLRVLRLTGGDLRPRAVADFAADLALHDWLLTALVEAIDRSGLEAGGGPATVQRLRPVIVHLLHHWMPAARLDVEGTELWRGLDAAAGLSRQWESLVARVRDQLALSTIGLLGSVALPENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI86</accession>
    <name>A0A010YI86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848748.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110230_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457875" evidence="2">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="22544" checksum="08D10DD7FEABA5F9" modified="2014-06-11" version="1">MSHRGPLLTLLSGAVVAAVLLGLSTQANTESTQQTAARAPSQSTPPAKASPSAAAPPPIASSSKPPTENRKAVFAGRVVGGRATVAISVKDGQAVAYYCDGDRTEAWMRGPASGGDLDLKGAPGGTLTGTFSRTKAAGTVTAGGRDYKFEAPLVKSPAGVYRGTVTIQGAKLVAGWIVLPDGTQVGVFTTDEGNPRPAPKIDLGSKTATVDGGTMTVTEADPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ88</accession>
    <name>A0A010YJ88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569835.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1306"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="337"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="488"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="622" mass="65910" checksum="8F440CDDD82B91BB" modified="2014-06-11" version="1">MRRFKFRGALFRDPVLLVYVGGALVVATWLLVAGAELAYELRVSWLTQLVLDTSLAVFAFRIARRPDLPRQARPFYRAITFTGVCFAVGDVSQIVIVFARAGPDAATAGPIQTASFLVGVTAAVAGVLLYPTAVRTVRERLRFWLDAATVLLGGAALAWALAAEPGVDRVSGLIAAGLVLVATFASTKLLYADAAPMTRIAVLPCIASAVTQGVGIFASSALGAQEHAGAAQALQVLAAMLIGTGFRIQELEFAAGLHPRRRKLQRSHNKLPYVATLAAAGTLVAVLPRSAGPKAWGVLLAVVVISVLVSIRQIDAFADNQALIQRLDKSLAALGQNERWYRSLLQHSTDITLVVDADGVLTFTSPAVKRVLGLSPDEALGLRLADLLHPDDREATDAAFRKLRARQGGTMTISARYRHADGSWRWLDGASTNLLEMAGVGGVVCNARDVTEARRFRDQLQHEATHDPLTGLPNRALFNERLAAGASGPCALLLVDLDDFKLINDVHGHPAGDAVLVAVAGRLRECARPGDTPARLGGDEFAVVLPETTPADAEAVAERFRTLLRAPIEADGDELAVGASVGVGVGTALGSEALLSIADQAMYRVKRAGRAAEPVVVRSGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK68</accession>
    <name>A0A010YK68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849595.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1685"/>
    <dbReference type="HOGENOM" id="CLU_034505_3_0_11"/>
    <dbReference type="OrthoDB" id="644190at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="35091" checksum="752EC097F08557E3" modified="2014-06-11" version="1">MTDQLTTAGLLLELEPVVETNLNRHLATAKEWFPHEYVPWSQGTDFDGVLGGTAWSEEQSTLSDVARTSLIVNLLTEDNLPSYHHEIAQMFGRDGAWGTWVHRWTAEEGRHGIAIRDYLLATRAVDPIALERARMVHMGTGFENAYLDDTVLHGIAYVSFQELATRVSHRNTGKISGDPICDQLLAKVAADENLHMIFYRNLLGAAFELAPDAAMRAVTDVVKTFQMPGHSIENFGRKSVQIAMAGIYDLRIHHDEVVIPVLRNLKALETTGLSDDGEKARDELVEFLAELDRQATRFSERRDKIAARKAARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKP2</accession>
    <name>A0A010YKP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849844.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1827"/>
    <dbReference type="HOGENOM" id="CLU_114867_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17615" checksum="F29B2A4A81930A3D" modified="2014-06-11" version="1">MSARGVLYVHSCPPAVCPHVEWAVARVLGVPVNLKWTAQHADPTTLRTESQWTGSPGTAGEIATALRAWPMTRFEITEEPSPGVDGERIMHVPGRGVHRSTMSANGDIMVSEDRLRSLLATAAGPDALAHGLEKLLAAEWDIELEPYRHAGDGAPVTWLHRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKY7</accession>
    <name>A0A010YKY7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="8" type="ORF">CryarDRAFT_1995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850020.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1960"/>
    <dbReference type="HOGENOM" id="CLU_053282_0_0_11"/>
    <dbReference type="OrthoDB" id="1634356at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="34538" checksum="D4F2523D0B7A8EB6" modified="2014-06-11" version="1">MAMTAAVKDELSRVVVTKPCCRKSEMAALLRFAGGLHIVAGRVVVEAELDTGNVARRLRQSIAEVYGHGSEVHVLTAGGLRKTSRYIVRVVREGDSLARQTGLLDVRGRPVRGLPPQVVSAAACCSEAAWRGAFLAHGSLTEPGRSAALEITCPGPEAALALVGAARRIGVTAKAREVRGVDRVVVRDGDAIGALLTRIGAHASVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVERAMEILSGDAPEHLLAAGRLRLAHGQASLEELGSLADPPLTKDAVAGRIRRLLALADKRAHDTGIPDTEASVTPEMLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLQ5</accession>
    <name>A0A010YLQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861765.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="178" mass="20613" checksum="D81E87D75BBE7D47" modified="2014-06-11" version="1">MDRDADDEFVRFVNERSRSLLRYGYVLAGDPHTAADLVQEALLRLRTAWARGKGREHPEAYARVTMARLHISWWRRRRGEQLIALVPDRTTWDPGLRRVEDDTGLWSALEVLGRRQRAVIVLRYYEGLDDDEIAEILGITRVTVRSQALRGLRRLRSHLTDDRVAALGVVDNERSNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM67</accession>
    <name>A0A010YM67_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725699.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2363"/>
    <dbReference type="HOGENOM" id="CLU_1198179_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="23575" checksum="0B0187F52ECF6884" modified="2014-06-11" version="1">MSDSGDTIDHGADAPTSTIADNDVPLDYDGDGTVDGYLHQNEDGTAYAALDLDHDGTAETVAADTDGDGYVDVVVSDTNGDGNVDYAIVDTDGDHVADTALYDRDGDGDFDYAVVDQNGDGVIDATAADTDNDGDFDAVEVDSDYDGDVDAVVVDTDDDGVFDTVYSDTDADGTVDTATTVTDAPDPAQVPDTAAADEAPATTTTTTTTTTTTQTATDPSVVTPQPTTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP04</accession>
    <name>A0A010YP04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851385.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2990"/>
    <dbReference type="HOGENOM" id="CLU_043966_3_1_11"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20996" checksum="2054F13627A1D48A" modified="2014-06-11" version="1">MGRVVMYASVSVDGFVADAHDRPGPLFDWLTGGDVPLDDSGVLAVSQRSYDYVRPYWDQIGVTIAGRHVFDLTDGWDGTPPSGVEHVVVVTHRPAPEGWDPGAPFHFVDGVEAAVATAQKLAGERVVEVAAGDVGGQVLAAGLVDEVRMDVVPVVFGAGKRYFGSVDAQHLLDDPDVVIPGNRVLHLRYPVRRSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQT8</accession>
    <name>A0A010YQT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852431.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_4_1_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="33692" checksum="F8606EF372D9E98C" modified="2014-06-11" version="1">MTEVVPTRTTLRPAFSLRSGVLTGIDSIMPVATVALMIFFAANKSSFLTTDNLLLVALQSAPLMVVAVGAALLLMCGYIDLSIGSVIAVSGVCAGLTFNAAGVTAGVLVGLGVGLAFGVVNGVLIGYLKLSPIIVTLGLLAAGRGLAQVLSPDALYGFPDPVLEFGNAKVFGVGTLVWIAGAVVVLGALLMTFLPVGRHIVAVGVNSRASYLSGIPVRRLVFGLYVLVGLLSALAGLLIVSRLDSAPSGTLGAGFEISVLTAVLLGGIPYSGGSGHLWRVVLGVWLMGILTNGITLMNVSSQLSQVLTGGVLVLAAALEGVRFWIHRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR90</accession>
    <name>A0A010YR90_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3879"/>
    <dbReference type="HOGENOM" id="CLU_031285_12_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458879" evidence="2">
        <location>
            <begin position="30"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="451" mass="48089" checksum="5A93DF370CEAF28F" modified="2014-06-11" version="1">MAYRSIRRPWLAALTLTGLLAAAACSAPGGDGGNTEASASAAPVTNATCGTDPITMEGYFETGFPLPKALTAEFTKQFPNVTWDIREDQFAVITQNAPRVLADDPPDLMRLPQVSELTKDGLLKNLDGYAKGFGWDKWPASQLEQMRVTASGERGDGPLYAMGLNFSMTGVFYNKKLAAQIGMTQPPTTLAEFDAVLQKAKAAGLVPINQFNGGATGGLAFPLQNLMAAYGDPAAINDWIYQKAGATIDTPTNLQATQHLQRWLKAGYFAPDINSQDYATMMSRFIGGKNLFIFDGDWESGNLDKQMAGNVGFFLMPSAKAGGTQAAMSAPLTFGIGSKSKNADCAAFFLNWVATNQQARDIDVKVGGSHPMGPADAYMPAVAKDTVTAATLDAGATIGEDNGAMDFIANATGAIYAKSWTPQLQKLAADQQTPEELLKSVQKDYESQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRT7</accession>
    <name>A0A010YRT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570706.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4107"/>
    <dbReference type="HOGENOM" id="CLU_421438_0_0_11"/>
    <dbReference type="OrthoDB" id="1143444at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="666" mass="75057" checksum="278F3DB9FD0322DA" modified="2014-06-11" version="1">MNTNVAKDSLVGVQAQNIYAEDVEATVVHGDFNRYELGPDDPPEKEFGIGVAQLDDGTPHTALDTISRARARGLLNNSVRFHWLLAFFSGRTVHQLDEHEVRRLQLAQEWIQPEGDDEWAEGLRTIENLLNNPGDRACAAKEIETLPDVPRRKILRHLELLLEGASRDALWEATAAQARADQFANDRTERVWKFFEADPVRPRPAPMEPGPARIALVKAAAACALFTSGAGYLAWIALRTQPWSAILPILAVALGVFAYASGTADWRIHRTRPDVRAAQYRYRPRTEVELLPELTRVGFTRQIDRYFAQYFREHMPADADASHWSSRTAAVRRKMRNDIVRQYRESRVSAERLRWLVEFRAEDVARRYRDGTLPGYAKRFRAITALALLLLGGVLLAFGGGLLIWLAVSGEPLRGLVAVLCALGSGVLAARWGIRVAVDKRLVAAENAEAVAQFARDLVEYRRWNDVLRDRPTDPEMAAWLDCDRKLLITAALERYKLLPSQVIAHAVLEAKAESSRRRARMRRGTWRYERYSVRVFLLTHDGVRQVAAEIDLARATRRTRQRANYRFDAIASVQVTETDARGQIFELTLINGDPIKEEVVASEVPDEDHLDADIARELTLDSAGLNNTLHVLEGIAAEGKEWARQRSRGTYRNDALRSLFGSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVC2</accession>
    <name>A0A010YVC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847545.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.116"/>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="16263" checksum="6666C1FF00C81598" modified="2014-06-11" version="1">MEYGDKLFWLSVLIQRKYAQICAEFDLTPSQATLLCAVRNEPRQMAYLAASLGMTKNALSQLVDRTARRELVGRESSAQDRRVVMLSATPTGKVLGEAIYAEVSKRLPEIARNLDPDDQRDFERVATAVVDTSDLSPTTSDQPITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVG7</accession>
    <name>A0A010YVG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569554.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400451_0_0_11"/>
    <dbReference type="OrthoDB" id="1920068at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="19768" checksum="4666E0E628EFE37C" modified="2014-06-11" version="1">MGEVLPLPHRGDVFLDPRGEGRSLRVSGHRGAATVVLSIWRQGECRATFRLAGSEVDEFIRALLNAAPPSAPGTDLPAVAGEPAAASVLQVQVSGNVVVELHNAVTDVVPTEVVPTEVVPVVPNDTTNATKVLVPPEPADVDLLDQAATTGDVLSALTAVPDAPEDSADPPQGPAPGPAAATGRNDPPGPDKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVI9</accession>
    <name>A0A010YVI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924082_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14329" checksum="1D481F7E5BED68C8" modified="2014-06-11" version="1">MGDNRGVAVRVRKQPIDWKRRTLVALPMLGQELLLPDEEQLSLFANETPAGGQGITVLWKPNPRKVELSRAVLALVHDIENSSKTRVLDFVDLPDPKVDMLGGVQVPSQPEPGDYEEFFGDASGIIGPDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVY6</accession>
    <name>A0A010YVY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase/secretion neighborhood CpaE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847842.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.305"/>
    <dbReference type="HOGENOM" id="CLU_042654_2_0_11"/>
    <dbReference type="OrthoDB" id="1646147at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="36974" checksum="FD25F7FBDA574F80" modified="2014-06-11" version="1">MSPPEACPLVCVRDPELTDNLLRLAAAAGADVEVPVDPIGARPLWTDAPLVIVGTDVVAEYVSARLPYRPGVVLAADERHVRPGDSAVWRVASDLGAEHVAFLPTAEAWLVDRLTEAVSGPRRAGRVVAVIGGRGGAGASVLSAALAVTAARNGSRTMLVDADPLGGGLDLLLGRENTGGLRWPDLVDTAGRVSPPALHDALPRVGELSVLSWDRGDVLAVPPEAAEAALDAGRRFSDLLVVDLPRRPDDAAVRVLQAADVTLLVVPAEVRACAAASRVVRAVRPHCAQLSCVVRGPAPAGLRSADLATALELPLAGVLRAEPRLAGALERGDVPAATGRGPLAGFCRSFLAELEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW85</accession>
    <name>A0A010YW85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860144.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195022_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7613" checksum="FE84DF8F0581D72F" modified="2014-06-11" version="1">MSLAVAAEALFVSPLQPSERPTPAEVEAAIDDSLRSFGGPTGCACWLAAEYGEHPEVAAERMRWALELTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWL3</accession>
    <name>A0A010YWL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848278.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.571"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="315" mass="33351" checksum="AA5F8825C305E61F" modified="2014-06-11" version="1">MSYAIEAEGLVKRFGSTTALNGVDLAVPTGTILGVLGPNGAGKTTAVRVLATLIKPDAGRARVGGFDVLTQAQSVRARIAVTGQYASIDEDLTGTENLTMIGRLLELSRRDAKARARELLERFELTEAAGRSAKTYSGGMRRRLDLAASLVGHPDVIYLDEPTTGLDPRSRGEVWSTIRALVADGVTVLLTTQYLDEADQLADSIAVIDRGELIATGTPDQLKAQVGDQTIEVHPLDEADLADVEAIVAAVTRVRPTRNQARGLVTAPVAEPTLLADVVRRLDDAGIAVGELGLRRASLDEVFLTLTGHPAEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX18</accession>
    <name>A0A010YX18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848465.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.729"/>
    <dbReference type="HOGENOM" id="CLU_146025_1_0_11"/>
    <dbReference type="OrthoDB" id="2035522at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16611" checksum="283AB89EE921AB9A" modified="2014-06-11" version="1">MADTKLTQARWTHVALPSGDLDKSIEFYTSLTPLVVLERFSDDAGQSAWLSNDKQVDSPFVLVLVDFNKDHGGQHGQLTPFAHIGIEVPNREDVDAIADKAREMGNLHWEPADIGGVVGYVCALKDPDGNVIEISHNQRVFSTIREKWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXH1</accession>
    <name>A0A010YXH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848657.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.913"/>
    <dbReference type="HOGENOM" id="CLU_003896_4_3_11"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="436" mass="47932" checksum="75E0038BFE595DFC" modified="2014-06-11" version="1">MTVLSPATNWAGNEHWAPTEVATPASVADLAATVREARERGLRIKPIGAAHSFTPIAATDGVQLSLDALGGVVRGDAETGLVTLRGGTRLRDIPRLLAPYGLNMTNLGDIDAQSIAGAISTGTHGTGGRFGGLSTQVRGLTLVLADGSIVDCDAERDPDLFEAARLGLGAIGVIAAVTLQCEPAFLLHAVERPVPLDEMLATVHERVDEHDHVEFFWFPHTSGTLYKQNDRLPGDALRKPLSRGRAWWDDEFLSNTVFAWACELGRAAPAAIRPIAAVSARALGAREYIDRSATVLCTQRRVRFRESEWSIPRAALGEALTEIRRLIERRGWRISFPVEVRMSAADDLWLSTAHGRDSAYVAVHQYHRTPHEEYFRAVQEIMLPLEGRPHWGKLHYLDAAELSGRYPRFQDFLAVRDRVDPDRAFSNAHLRQVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXP7</accession>
    <name>A0A010YXP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848742.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050180_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458891" evidence="1">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="60"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="256" mass="25652" checksum="0BA20BB028C90B36" modified="2014-06-11" version="1">MKLSTVAAGAATAAATAAGAAVSVLAIEGLLARRRRYLSADLAPPGSGVFGTGRPLRLALLGDSTAAGLGVMVTGETVGGRLAELLASTGRRVHLSSAAVAGSRTADLDAQVARVLVHGVPDVAVILIGGEDAIAFTPLDVVEAELTATVRRLVAAGSAVVVGTCPDLGAARNFGQPLREIMAWSGRRVATASARAAADAEGGVVDLAGRTGGVFRADGGTLSADGYHPSADGYQLWALALYPLVYEASRTTSGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXT6</accession>
    <name>A0A010YXT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848773.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1719285_0_0_11"/>
    <dbReference type="OrthoDB" id="396645at201174"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="152" mass="16182" checksum="C71DC997387F7C53" modified="2014-06-11" version="1">MTRTATASTALLDQVDAAAADARRLWAEHFVPQLDQTSPVPSTSLGLQRVHAAFIAAVGGLRTGTTRCCPHVDLSAPRPMVWVAWRPRVIQCGHPECMLALDVAATGQDDYVCDGCSRYAPSTLTAVSWTSGVFLLGADLCRRCRTTPGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY72</accession>
    <name>A0A010YY72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="24405" checksum="A4BFF04C6ED29EC0" modified="2014-06-11" version="1">MGLLITVAAVDDDPLVLQGLSAWLAPADSGIVVIDLVQSVEELLHGRGRQADVVLLDVWLGDESRVGDNVRAITAVGPAVVTISTQDITDLIVESIEAGALSYVHKSLDPTEIRAAVRSAASRQKFMTPALAFALRSDQRPARPSLSLQETESLRLYASGLRMTDVARRLGVKPSTAKGYLDRVRAKYDDAGRAARTKLDLRERALEDGILRGTTALGPRAVRRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ99</accession>
    <name>A0A010YZ99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075566_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="19792" checksum="E355387C6216152C" modified="2014-06-11" version="1">MISGMTGPGLLREARALVFVLVCLSLSVALHSWAHGEVPPLLAVLAGGGLVLSVALPLTGRQRGLPTIAAALAVTQLGLHLVFSMMPTQHVMVPAHGPGTMIAGHVVAGGLAALWLHAGEVAVWRLVRRLAQRLPALGVLFALAALRIPAPAPRRFRPRTAELAAPPPEPTWLRSATRRGPPALLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZF0</accession>
    <name>A0A010YZF0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849551.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1643"/>
    <dbReference type="HOGENOM" id="CLU_009665_14_0_11"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="589" mass="64186" checksum="FC7CEB5884FC88A6" modified="2014-06-11" version="1">MDSVVPTVDTEVLVIGSGPAGAAAALFLATYGTRVTILTKYGRLSETPRAHITNQRTMETLRDMGLEERLMREATPWELMGNTTFCTSLVGAELGRVSSWGTDIRRHADYQLASPCTMVDAPQTITEPILVQAAQARGARVRFDTEYLSHVQDADGVTTRVRDRLTGAEYDVRSLYLVGADGARSKVAADAGLPFEGPGAVAGALNIIIEADLTRFVAHRPSVLYWMLQPGAEKEGVGLGVLRMIKPWSEWMLMWGYEVAAGPPDLTDDFIRQLAVQLVGTDDFEMRIKSSSPWTVNHQFASRLANGRVFCVGDAVHRHPPTNGLGSNTSIQDSYNLAWKLHHVVRGLARPSLLDSYDAERAPIARQIVERANQSIADTGRIIEALDVDDTSNVERLERQLALREAPGPDGEKIRTALREAIAYKSFEFNAHGVEHNQRYASDAVIPDGTPMPAYERDSELYAQPTTWPGAKLPHTWVTRAGHRISTLDLAGSGQFTVLTGIGGQAWVDAAAALSASLGVAIRTVVVGPAQEIEDPYGTWADLREIHDGGVLLVRPDLYIAARHVEAPENPQAATTFLADALERVLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZF6</accession>
    <name>A0A010YZF6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725679.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1648"/>
    <dbReference type="HOGENOM" id="CLU_1204246_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="27665" checksum="34F1398DABCE47EA" modified="2014-06-11" version="1">MAWLERVELLASVAGPFDRWLTPRREMSWEPSAAPIDGPVAKLGGQPFWVDEPFWPVSRSSGEPMTFIGQFPLPGSGIAMAYLFLSDEDGTFDLEGGENAFLIQPGGRVPPFVSGQVRRTGPTLWRRGADWFERHPVELRLDLKAPDEAAIATFERQVVHRDAALNGTPIEEDADLPELGCRNYVGGEPLFWQPWTPPALDASWRFFFQLDGAEGWGDDAFALNFGGGTGYAFLDPDRREGRFCWDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z049</accession>
    <name>A0A010Z049_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849913.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1881"/>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_11"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="105"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="450" mass="50734" checksum="F0DBEDF02945D2AA" modified="2014-06-11" version="1">MDRQQDFVLRTLEERDIRFVRLWFTDVLGTLKSVSVAPAELEAAFEEGIGFDGSAIEGFTRVYEADMVAMPDPSTFQVFPFEGAGSGESARMFCDIQMPDGSPSWADPRHVLRRALRKAADKGFTFYTHPEIEFFLLADHPTDGRRPTPVDSGGYFDHTTHATARDFRRQAVLALERIGISVEFSHHETAPGQQEIDLRYADALATADNIMTFRHVIKEVALFQGVSATFMPKPFTDLAGNGMHTHLSLFEGERNAFHDPGDPMTLSKTAKAFIAGMLFHAREYTAVTNQWVNSYKRLFGAPQHNVVNEAPSAISWGHLNRSALVRVPRYGKPHSARVEIRSVDAACNPYLTFAVLLAAGLKGIEEGYELPPGAEDDVWSLSPEERRALGYEDLPHNLSEALGYMEKSELVAETLGEQIFDFFLKNKRAEWDDYRRQVTAYERRRYLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z095</accession>
    <name>A0A010Z095_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1932"/>
    <dbReference type="HOGENOM" id="CLU_494962_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="550" mass="54713" checksum="E7430A6DD49B2919" modified="2014-06-11" version="1">MVRLATPNYTLGSVVLLRDHDDRLLLVRQPPATGWSLPGGLLDRREHPRDAAVREVREEIGVSLDPDTVTPIVPNAHVNPWVQQVDLIFTATVDADDVVLTVDEVEIGEARWYALDALPPLTGPTFRLLGRAGLVSPDATPGAPAPAPEALPGSGSSTSSGASPSTDKARGSIASTTAGMSPTADTSTTAGMSATAGTSTTADTANLPVESTPSATDAASSAGDGEGDARSDSEAYPAEGGTPDAAPTELVRASETEGSSKAAAAATASSTLTAPATPERRSDTDSDTEAAAPTAAPTAAPTAAPTAAPTAAERSTSASGSTTSAQASEMGTRTEATVPASEAAELSASTAATATLVPPSETGIATAPAAGTPERATPDTRAPDTSTPDTSTPDTSTPDTSTPDTSTPDTSTPDTPAPDTSTLNTLTPNTPTPNNAAQDSWTSTDTGTADGSAADVAAPGATSAPATVMGAVLDGGAERTDAVLAEPGEVFGDPEAAPHAAPNKNAALHKHAAPGTHTGPKKHTDADQHASPDQHASPGQHAAPYDEEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0M0</accession>
    <name>A0A010Z0M0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850149.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2062"/>
    <dbReference type="HOGENOM" id="CLU_142189_0_0_11"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="110" mass="11937" checksum="4EA6DC53C4ED14DB" modified="2014-06-11" version="1">MTDPRFDELIHAPTRLGIVAQLAAADWVVFKFLRDSLNLSDSALSKQLTTLNEAGYVEIHKALAGKRPRTTVRLTPAGRAAFEGHVAALEDIVARSRSSLRPEPSPSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1R2</accession>
    <name>A0A010Z1R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570063.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151322_1_0_11"/>
    <dbReference type="OrthoDB" id="1918051at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="98" mass="9715" checksum="6BDE9751ED657D63" modified="2014-06-11" version="1">MLTHVIQATAGIPDEILAAADPGGTTLNTDGIVGFIVSKIVPILLAVVGVIILSRSGKGQWSAALTTGGIALLGIVFIAGAGLLFAFGQSFAELVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1W7</accession>
    <name>A0A010Z1W7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850735.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2498"/>
    <dbReference type="HOGENOM" id="CLU_543818_0_0_11"/>
    <dbReference type="OrthoDB" id="1419476at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="480" mass="51639" checksum="62DFD63B6208F168" modified="2014-06-11" version="1">MSAIAAYARALAVVEGVAQPITTVAHVHVAARPLVLVPLALAGEANAPLAALVGTDPASPRLLIVPQPRDRQLRFAFAASLADVVLDYLSGFPVTEGDEPTADDAPQLWVPNRGGFAFLRLFGRSTRFRRTTGPYPVAPGVPVLGRWLTWFAERSEYPGASTLLAATEVLGAHWATGQSALEDANLAALLGWIDPPPGRSAREAARDAEDALRWPPAGPSTDPTFDNEVLSPAISAYGSSPDGSALRRRALAGLESALRGQTQPTWELVWRAIDRMRTLTPGGSVAGRWAADARQYASFHRWMAEDGLPQARRDGAVAAARRLLRLEWAHQEYAVSRSFDDPRVMADFRVTGEAFRGTVTEVDAERRVENENGNLVKRPLVVVRTEDPVHLAVGTAVGSPARPKQSGRVLEIDDGLVTVEIAKGLREALPRVGDDLTYSSVLSSGGRGPNLPPVEDTPWTHGGPPEPYVPTDEDAVETWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z350</accession>
    <name>A0A010Z350_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2952664_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="59" mass="6467" checksum="EFE9C8A34215AA97" modified="2014-06-11" version="1">MRCVCCGEWAIEPVTLDGVPRLRLSCRGYLVGYYTAPESLAAELRRQHGPGLADFRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3A5</accession>
    <name>A0A010Z3A5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851355.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2973"/>
    <dbReference type="HOGENOM" id="CLU_000288_169_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="571" mass="59581" checksum="3871D507593AF356" modified="2014-06-11" version="1">MHRPPDVPGYAIRDVLGSGGCATVYLATQIVVGRDVAVKIDNRTLTTERDQRRFYREVNAAGRLSDHPNVIGLYDAGTLADGRPYLVMELCTGGSLATVLKRRGGLPPDEVQAMSVGLADALGAAHSLGVLHRDLKPGNILVNRYGMVGLADFGLASIITADAEQSATLESLTPAYAPPEAFSLVEPAPSADVYSFGATLYALLSGRPPRFPDTGSPSLAAIVRMHDEPLPVLPWVPGALMSVIERAMAPNPADRFPDGAAMRAALARTPVTFSSSAWPGYAPEHATGDPASPTTSGASFRPPGGDRHSASVSAPPRSGPPQVRAAHGASFSVPPHSGPPYSIPHQSIPHQSIPHRPPPHHTGPHQAPASERRGMSARKAAVLTAVGVLTLVAVVAAGLVAATRPWNEETGLPTVESANQAPTAATRSGPDYGVETTTGNCPATANGGRCVVEPECWSGMVVIVGQVTIERQPCEDLHRWETFAIAPLPRDALTSSQKTLAAHPAVKKLCSTDVMLASRRANAPTIPVAEWSVDVLPPSEAAFADGSRVYRCVAAVISPDTDGSTGSAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z458</accession>
    <name>A0A010Z458_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3270"/>
    <dbReference type="HOGENOM" id="CLU_572013_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="311"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="477" mass="53330" checksum="BA07CC34E64FC65D" modified="2014-06-11" version="1">MFDPLEHPGIPVGHRRRHWREFDVEPVDPRATDPYTRCRIRMGAVVEATAELFDRQFADHVRGADEHRVVSRLGDAAAERRRHATAARAVPRSAVEEAMDREWAAFDLAGWAARNECEPDRSTAYRQEAWQHLERLHRYTGFGARARLPGADQIADEVQGLSLPPVVTAPADSRPPSAPVTQPLSLLHDWMMHAAGRSAAGFRAGSSDAGWAALVVNESANCYLYYGFLAEEDDRRLRPVWELQLQMRLTRLHAASDLLRRYGGRDPQEVIGEGLPEPLSLRTDRSSLPADEPDALRPPDRDQDRKGPDVLELLTGHHDRMKRLCGRAARSARDDAYVAFGELARLITLHEIAEEQMLHPLVRRLRPDDQLVDHLLDEESRISDALSDAVRAAAHGHLDDTIGGLREMVTAHARCEEHHEFPQLRSSVPVPERREMGRAVRAAEAADAEAGPPDPEPVGPRALAQTVERVRDAFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4L2</accession>
    <name>A0A010Z4L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="42" mass="5400" checksum="23F670394963EC0F" modified="2014-06-11" version="1">MSGCYDYDYNQCNDWDYNECKPRRRRHHKKRYNDCWDYNPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z548</accession>
    <name>A0A010Z548_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin resistance ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864411.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3624"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="323" mass="34203" checksum="556B1244C41A2BD3" modified="2014-06-11" version="1">MAVTERSAIEAHGLVKRFGTVRALDGLDVHVPIGEVLGLLGPNGAGKSTAVRILTTLLRPDAGTARILGHDVRDAPGQIRRLIGVSGQYVAVDAHLTGRENLRMIGRLSGLSRTDAKRRADHLLETFDLGSASGRTARTLSGGTRRRLDVAASLVAAPAVLFLDEPTTGLDPRGRTELWRLLDELRSSGTSLLLTTQYLEEADRLATRILVLHRGRAIATGSPEELKRQVGGDRLELRTLPGADPRALAAAVCDLGTGPPVIDAGTERVLLPVADGPGALLGVATRLAAADLRISDVALRRPTLDEVFFTLTGPGGPADRRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z666</accession>
    <name>A0A010Z666_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852727.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3955"/>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="176" mass="18498" checksum="37E1D01225C852C7" modified="2014-06-11" version="1">MAIDLDALDVDLLSALRDHTRVGVLELSRTLRVARGTVQARLDRLERAGVLTGHGPDVDLAVAGYVVQAFVTLEIAQGALDEVTAELTAHPAVVEAYATTGSADVICRLVASSHEDLQRHLLTINQSARVSRSTSVVILSVVVAPRALPLLESAPRPAPRRAPAYQDGDAAASPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6S2</accession>
    <name>A0A010Z6S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ca2+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853248.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050648_1_0_11"/>
    <dbReference type="OrthoDB" id="988251at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="223"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="367" mass="37260" checksum="D30F0FE789B4D20E" modified="2014-06-11" version="1">MASSLRQRLSYWTAVIPVAALVALALAWGRELGPVAVTIVALLLAGAVLAAVHHAEVVAHRVGEPFGSLILAVAVTVIEVGLIVTLMASGGSEASVLARDTVFAAVMITLNGIVGLGLLVGARKHGILAFNAEGTGGALATVATLAALSLVLPTFTTSRPGPEFSPAQLAFAAVASLVLWGMFVLTQTVRHRDFFLPVTLDGEVVDAHEEHAAPPSARAAAISLALLVVALVGVVGLAKLESPAIEAGVKGAGLPQSFVGVVIALLVLLPETLAATRAALRNRIQISLNLALGSAMASIGLTIPAIAIASIWLDGPLSLGLGSTQMVLLALTVMVSVLTVVPGRATRLQGGVHLVLLAAFLFLAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKP4</accession>
    <name>A0A010ZKP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847737.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924083_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14198" checksum="2B71962032065966" modified="2014-06-11" version="1">MISPVTMLRPRPDRVTEYIEPHTVRAPVSRAGGTLRALTAALAPHLSTTDPELHGLAACLLTAQEAYASDASTDREELRRQYHGAAQDYCVAMDRRGFATPPGLRQAVRWLADPATGADEPVRVPPADPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL23</accession>
    <name>A0A010ZL23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847909.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.359"/>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="30086" checksum="052FB29712714298" modified="2014-06-11" version="1">METADREVVGARLREARQSAGITLRAAAEALGVSVGTWSAVENGRTRITTDRVSAAASLFGTDVEILVTAHRPPASPHHTWRDFPPLDLPAPLRGALSAFVELGYHGATIRDIAQRADLSVPGLYHHWPTKQHLLVALMDRTMDELITRAEAARAEGDGPVERFKLLIEFLALFHTHRRELGFIGASEMRSIDEPDRSRIAAVRVGLQRMVDAEVREAVRRGLFTTPLPHEASRAVVTMCTALPSWWSPNGPTPPATVAAQYVEFALDLVRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLD1</accession>
    <name>A0A010ZLD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569634.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_43_3_11"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="31544" checksum="93F66FB9B8ECA3B4" modified="2014-06-11" version="1">MSRESSSTVRSADGTAIGVLSTGEGPGLVVVPGNNRRATHYRALADELAEDYRVHVIDRRGRGDSGPQGPFYSIEAEAADVHAVLRATGSDLLFGHGHGGLVALHLALWRPVDALIVYEPTVSISGSFDAGWVPEFRRQLATGRHGAAMATFLKGTRMVPLGNAPMIVYRALAELLLHGDEGVETRAIMATTPAEVDEIARLDSDGRRYAAIHSPTLLLGGGRSADYLTTALHRLHELMADSECRVRPELDHYAPDYFAPRVVAQEIAAFITNRNAARVQLGIKGALGSLVGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLU0</accession>
    <name>A0A010ZLU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569680.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_2_1_11"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="23264" checksum="39C7264589993A70" modified="2014-06-11" version="1">MTATLASAEVLATAWPDRIADAASASYPVLVVAVLLGAIVPVIPTGAAVSAAAVLAVHNGGVSLIQVIVLAAVSAWLGDCVVYALFRWGRRGVTRFIARHPIDSPEANDRLEETRRRLTENGTQVLVVSRLIPGGRLPTMFAASAIRYPWPRYVSGAGVAAIVWAIAYAVMGLLGGSLFSNPLVGIAVTVVATLLVSLIARYVQRWLANRQSRESSAAGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMA7</accession>
    <name>A0A010ZMA7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase CobN subunit</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848544.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.808"/>
    <dbReference type="HOGENOM" id="CLU_002017_1_0_11"/>
    <dbReference type="OrthoDB" id="8025at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1193" mass="128566" checksum="0F69180DC9394F8D" modified="2014-06-11" version="1">MILLLSTSDTDLLSARASGASYRLANPARTGVDDLPGLTDGVDLVVVRILGGRRAWEEGLDALLAGPLPVIVLGGEIAPDADLMQLSTVPMGAAAEAHAYLAQGGAANLQQLHNFLSDTVLLTGLGFEPPAEMPTWGVLERESRGDGPTIAVLYYRAHHIAGNTAFVEALSGAIEDAGGRALPIFCASLRTAPAELLTTLRTADALVVTVLAAGGTKPATVSAGGDDDAWDVGALAALDVPILQGLCLTSSRATWDANDDGLSPLDNATQVAIPEFDGRIITVPFSFKEIDADGLTVYVADPERAARVAGIAVKHGILRHIAPEKKRIALMLSAYPTKHARVGNAVGLDTPKSAVKLLQALADAGYEVGDLPGVEAQDGDALIHALIKAGGHDTAWLTEEQLAANPVRIPAETYKKYFDSLDEKLREAMERHWGPPPGELYVHEGDIVLAALRGENVVVMIQPPRGFGENPVAIYHDPDLPPSHHYLAAYRWLAAEFHADAVVHLGKHGNLEWLPGKTVGMSAADGSDAALGDLPLIYPFLVNDPGEGTQAKRRTHATLVDHLVPPMARADSYGDIARLEQLLDEHANIAALDPAKLPAIRAQIWTLIQAARLDHDLGLDDRPHDTEFDDFLLHVDGWLCEVKDVQIRDGLHVLGDAPAGEARVNLVLAMLRARQMWAGQVAALPGLREALGLSEAGDEARSDVDTIDAIARDLVAAMEERDWDPTVGAEVTAQVLDATSGAADADRALVARVLEFAATEVVPRLNKTTDEMAHVLHALNGGYVPAGPSGSPLRGLINTLPTGRNFYSVDPKAVPSRLAWETGSAMADSLLTRYREDTGDWPRSVGLSIWGTSAMRTAGDDIAEVLALLGVRPVWDEQSRRVSGLELIASDELNRPRIDVTMRISGFFRDAFPHVIAMLDDAVQLVAALEEPDNYVREHVLADLAGQKSERQATMRLFGSKPGAYGAGLLQAIDSRTWRDDKDLAEVYAVWGGYAYGRDLDGVPARPDMENAYRRINIAAKNVDTAEHDIADSDDYFQYHGGMIATVRALTGQSPKAYIGDSTRPDAVRTRSLHEETARVFRARVVNPRWIEAMRRHGYKGAFELAATVDYLFGYDATAGVVADWMYEKLAATYALDAENQKFFGESNPWALHAITERLIEAADRGLWEHPDAETLAALQDLYLATEGDLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMK1</accession>
    <name>A0A010ZMK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.940"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="392" mass="41764" checksum="E6F7F4A343FDA6AA" modified="2014-06-11" version="1">MRVLVIGGGVAGSATAIALHRAGIDAEIYERHPGVADDVGLFLTFAGNGIDALQVLGAAEPVEKTAFPTPRMVMRSGTGRVLGSMSNGDASRTIRRADLYRVLRDEVVRRGIPIHYGKALADVEPSATGVRARFGDGTDASGDLLVGADGLHSPTRNLIDPDAPAPRYVPVLNTGGYARGVAVDAEPGTFTMVFGKRAFFGYVPAPNGEVWWFANPPYPTAPSAAELAGMNAGGAWRRRLLELYADDATPAVALIEASTNPMTGWATYDLPAVPNWYRDRMVLVGDAAHATSPSSGQGASMAIEDAVVLAKSLRDVPDRAEALATYVGIRRPRVERVVKAGARSSSMKVAGPVGRVVRDAMMPLFLPMASRMMKTEWMHRYHIDWDVPVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMS6</accession>
    <name>A0A010ZMS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1020"/>
    <dbReference type="HOGENOM" id="CLU_413778_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="504"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="679" mass="72414" checksum="96BB458046E6CF86" modified="2014-06-11" version="1">MQKYAQRLRAGVALLTTVPRLPPAVQPVRAVVWALHLLVPVAGLWLLLAVPAADVLWHHPPSHFWLVLNVAAISLLPGIAMTAAALNRRDARLFLVSLCFLSSAGFLLLHALATPLVLVDHANVGFDLSQPTGLTISAVFAALSALPLDSDRVLALRIPLWGGLTAVMVAWGAVTLLDLPPLNAAPQVRDVEGWQTAVAVLAVALYVAAALRYYQLHRRAPAAVLVSILTAFVLLAEAMVAVTLADKWHLSWWEWHVLLVFAFGFVAYSAYVQYRKEGSSAGLFDAVMLAPTVRAVRAQYEAALEELVTVLRERERSGRTTAEPLAQQLAQRFGLTERQAVVLDRAGTALAAEREISALLGALVTVGERARVGLGERELLDEVLARVRPAYGEVHVGLVDNGALSVDGRAYDPATLTAPRRDDERLIYPLTVKGRVAGVVEIPARSGETWAALLANQLSIVVENARLYAELGTLFRQYLSPDVASALLADPAQAALGGSIVEVTALFADLRGFTTFSEQADPTEIVTMLNRYHGVAVPCILDNGGTVVQFVGDALLALFNAPARQPDHAARAVRAGLGLQTAVDAIAEGRPGWPRFRVGINTGSALVGNIGSEALRGFNAMGDAVNVAARLQTLAQPGQVVIGDATMKQLGPEVSAYSLGELTVKGRLQPVRAYVVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN43</accession>
    <name>A0A010ZN43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848892.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1154"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_11"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="9"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="34206" checksum="82248A10481C0D89" modified="2014-06-11" version="1">MTRYDSLLDALGDTPLVGLPRLSPSEDVRLWAKLEDRNPTGSVKDRPAIYMIAEAEQEGRLRPGDTILEPTSGNTGISLAMAAKLKGYRLICVMPENTSIERRQLLGMYGAEIISSPAAGGSNQAVAMAKQLAEEHPDWKMLYQYGNPANARAHYETTGPEILRDCPTITHFVAGLGTTGTLMGTGRFLREKVPDVQIIAAEPRYGELVYGLRNIDEGFVPELYDASVLTTRFSVGPRDALLRTRQLIEVEGIFAGLSTGAILHAALATAHKAVKAEQRADIVFVVCDAGWKYLSTGAYAGTLAEAEAALEGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN66</accession>
    <name>A0A010ZN66_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="44"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="30254" checksum="4ED9AD4D3EA4BE0F" modified="2014-06-11" version="1">MPTDTLRLGADLTVTTLCDAAGTFPEPLEDAFPDAGNTGRWPMHVHCHLVRTPTRTVLVDAGIGPEWAPAGEWFGRPGRLPEELAALGVEPEEITDVILTHLHPDHIGWVVADEDDPKPYFVNARHVVQNAELKWLRESGEEYEDLYDSHIKPLVDAQLLVEVTGAATLDERLDLVLAPGHTPGHQCLLVDAPDRPLLITGDAFVHRGQMTTAGLAYRYEEATDDAAKTRRRLLSVAAERGVLLAPCHLDEGVVLVESASEDSFRTTAMARCPNSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNW1</accession>
    <name>A0A010ZNW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849225.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1416"/>
    <dbReference type="HOGENOM" id="CLU_047691_15_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="169" mass="18853" checksum="35FAE0128CAB59A5" modified="2014-06-11" version="1">MTGTGRDFGRFYADNFPVLCKQLYAYTGDAAEAQDAVQEAFVRAWTRWAAVSAYESPAAWVRQVAWRLAISRWRRARTALRFVHGQREVHAPPPGPEHVTLVAALATLPERQRRAVVLHYLADLSIAQIAAEESVAEGTVKSWLHRGRAALAAHIADERMEGAYDDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPN8</accession>
    <name>A0A010ZPN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569933.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1698"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="19932" checksum="469969707E5A18D9" modified="2014-06-11" version="1">MNGVTEAELVRRVADGDRAAFDELYRRTAPWLAVRLRRRCADDDLVADVLQETYLAVWRAAGSYAGSVTEGSAVGWLWTIAANRLVDAFRRRARQERVPAVPLVPRTAPAAEDEVMATRVDQDLEQALLRLPPELRQVLQAMVLDGLSVRQTSVLLGMPEGTVKTRARRARIALREALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQA4</accession>
    <name>A0A010ZQA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.400"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="34612" checksum="25A26A20DE0589AB" modified="2014-06-11" version="1">MIASAVERPHKRFTDAADAHAVTTTGLTKQFRGGQVAVDHIDLAVPTGAVYGFLGPNGSGKTTTIRMLLGLTRPTAGTHRLLNGRMPEDAATLLPRVGALVEGPAFHPHLSGLDNLRRLDAVDRTADPTTARARIGAALDRVGLTPAGRKKYRAYSLGMRQRLGLAAALLRPRDLFVLDEPTNGLDPQGTREVRTLIAELSAAGTTVMLSTHLLAEVEQVCTHVGVMNSGRLVAQAPLAELRAGTATRVEVETDRPVDAIATMQRLELPDIVVQGHRVGAALGELPSDRVVAALVYDGVPVQGFRVVVPDLESVFVGLTGEGFDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQD7</accession>
    <name>A0A010ZQD7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569976.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066404_0_0_11"/>
    <dbReference type="OrthoDB" id="1944106at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="357" mass="36855" checksum="FA11196B298FDCB4" modified="2014-06-11" version="1">MTGTSGRPYRGRRDNGLDATEFVALADVDPRIGEHLLDVLGVIGIAAYLAPSADLNPVVRSTSLPARPTDRLWVDRDRLEEARGLLEAVQEDALQSEESARSGAPETGASRPIEIDVDVEWERIIAGYDATAAPDRPRRRALIEPPESGAADGTAESPTPGSGNSGSGASSGGAIVDGTAAVPALTDPTADPLPVRTPGTADQPVRPDEPAGPTDDAPSTDTPSTDAPATGAPSTDTPSTERPGPERPASGDVAGRPLGRDRLTGTDAPPSDFPVDEDEGYEPPPPPPLPRMSAPVIGALLAIAAGLVLLFRSDTLGLSEHVRLLLSLCGILGGAGALVWRLRDGWNDDDPDDGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQK4</accession>
    <name>A0A010ZQK4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar biosynthesis pathway, component FlhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850089.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2019"/>
    <dbReference type="HOGENOM" id="CLU_041013_1_2_11"/>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="368" mass="39617" checksum="5A8AEC3D4CBA86E6" modified="2014-06-11" version="1">MSGEKTEKPTPQKKKKARKEGQIARTPDLGAWVGMLLASFLLPMVIRSMMDRARTLFEKAIDVVEDPDANRMLGLLTDMLPAIALTVAPLAVGMMLTGIGSTAAQGGLNFATKLLKPKFSKLNPFSGLKKILGPHALWEAIKTIVKSGVIGAVLYWSIKDVIPVLMGNGQIPTAVIMEQVVVTVERLIRSAAAAGLVMAAADYAVAKRRTDKQLRMSKQDIKEEHKKSEGDPHVKGAIRAKQMAMSRNRMMADVPKADAVIVNPTHYAVALRYDPLKGAPRVVAKGTGTIAQKIRELGTENRVPVIQDVALARTLYKACDIGQEIPPELYAAVATVLAFVMSLKAKGAAAGTHRLPANRRVALPAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQS2</accession>
    <name>A0A010ZQS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992950_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="280" mass="29360" checksum="1BB7464AD2B42A2B" modified="2014-06-11" version="1">MGGFRAGAFRGAGALRAVEGFRGAEVLRAVDAFLAGGASSFTGDSPGGETAGAGGTAESPGADTGSATITAPFNPLSNSPSGCIRSLQSLAHHQCGGARLSAETRATCQRVNRRPPREHDRPRRDCGPPSAARPPKGTPTTARLPTNAPPRPKPHPRPRPHPRKPHPRKPHPRKPHPPLPQPHSPHRRPQSATPPRPTARPPNPPHQPRTTPAGSSARPVRLGGPATACPPRTPLRARSPGRSRRSSPPQNTCLTPATQVNHRPPQPVCESAPPASRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQZ3</accession>
    <name>A0A010ZQZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.659"/>
    <dbReference type="HOGENOM" id="CLU_727075_0_0_11"/>
    <dbReference type="OrthoDB" id="1814039at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="38947" checksum="FA72AA87BE683105" modified="2014-06-11" version="1">MTRVQPEDPVPGWSTPPLPNQSVAWRPPQPQADDTPPAPLLDLRPAAPPEPPLTALPEPALTAPPPQGGARPPEPPRPAPPLPALPPQAGGLPPVPHFLAQTGSAPAPARGRTRIAVLVGVIAAVLVVVAGVTTTLALRPNTDPELLRAESSPVASDPPQLGAESNAGPEAGSAPSGPQRDSDKATTGSPTTDPGEGATTSEAPVEPAPRTEGTDPTEPQQPTEAPQATEAPKTQAPTTKAPATKAPATKAPATKAPATKPPATKAPAKKAPEIDKAVAKSGKRGAGPCSAKLVGGYGCYQTYGDLWWVYDTKGDSHSAVVFWELGNRSGQCANSMGNGKIGACNKNYAEGSTGRAKVCIMDWDTKQMHGCTAYFTFKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR37</accession>
    <name>A0A010ZR37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriophytochrome (Light-regulated signal transduction histidine kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860394.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.701"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="189"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="406" mass="43536" checksum="7B2A64EDF36141B7" modified="2014-06-11" version="1">MSTLRSRAQMLEPYAIIGEPPEPDLEAIASIAAHICGAPTAVVNLIDDTHQHQVAAHGFARSVCDREDSMCAVSIALPEPVYLPDARLDPRWADNPFVTGVIGDVRFYSSTQLINARGEVLGTLCVFDEEVREITADQRTQLELLAHQVVDVLELRRQSFELHAAIAQLEHAREELERSNEHLAAFAGQVSHDLKNPLASVVGYLHNLSEVGAVVSEPEAAWCTQRALAASQRMSDMIGHLLDYASVGGSLTLVPVDLGQVVADLTDDLSDAIASVGGALAVEGQLPTVAGDSVQLRAVLQNLISNALKFRRLSRPPRVVVSAAGRDGTWLVRVADNGIGIPSDRREQAFALLSRVHDESAREIAGNGIGLATCKRIVTAHGGEIGLTDTPGGGTTVWFTLPVDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRG8</accession>
    <name>A0A010ZRG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848548.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.811"/>
    <dbReference type="HOGENOM" id="CLU_016218_2_0_11"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="36661" checksum="9AE6B494513B0485" modified="2014-06-11" version="1">MRPVLDDSVRLTDEGVLILDRRVFPAREEWVLTRTAGEVAVAIRAMVTQSSGPFYAGLAGLRLSARLHRGDGLDTALQALADDGELLTAARPTNNHVRDAVREVLDAVGAAGSADELAELVEAETARLEAAYRGGSAELGRLTTELIPDGARVMTHCWMDAYLIGLVQQAELAGRKYEWVVTETRPYLQGARLTAHTLAEMGQPLTLITDSTAASVLAGQGALGSVDALVTAADRVTMDGHVINKVGTLSHAVAASAFEVPFYALVLAPDRTAATASDVVIEERDGAEVLSTLGSRTASALVERGYYPAFDVTPPEFVRRIVTDRGVFEPARVGEYHERQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRH8</accession>
    <name>A0A010ZRH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848573.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1600306_0_0_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="17466" checksum="93BD3EFE8D5982BF" modified="2014-06-11" version="1">MEDTRTLLEDYVSSGKVIQLATLDAAGAPVVCNLWFASAFGPDRIWFMSRPNREHCANLRADPRVAGAILAIELEGIEQDVRGVTFVGAARELPTVGIDEQIAAYSGRWPQAADAIAPEALAAEATPHRLYEITVEKWVLFDELYFPDQPKQPVRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRW2</accession>
    <name>A0A010ZRW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar phosphatase of HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850691.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2459"/>
    <dbReference type="HOGENOM" id="CLU_043473_1_0_11"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041065">
        <property type="entry name" value="GNAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18407">
        <property type="entry name" value="GNAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GNAT_like" evidence="1">
        <location>
            <begin position="279"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="34551" checksum="7C450A83A6E35CAF" modified="2014-06-11" version="1">MTGLRGTDEPLSALYDAALFDLDGVLYLQEDPIPQAPDGVAAARAAGMRIGFVTNNASRRAPTVVALLGRVGVKATEDEVVTAAQASAALLAEELPAGSAVLIVGAQGLADEVADVGLRPVRSADEKPAAVVQGFAKEVGWEQLAEAAVALRSGARWVATNRDFTIPSTRGPLPGNGSLVAVLTTALRREPDVIVGKPHPRLHQESVRRIGADRPLVVGDRLDTDIAGAVNGGADSLLVMTGVTDASGLLAARSGERPTYVAADLLSGLTEPHPAVPAGWTVTADGSGLVLGGAGSSLDALRALATAAWALPGADDDAWPGPSAVRADGAAAQEALDSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRY0</accession>
    <name>A0A010ZRY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2484"/>
    <dbReference type="HOGENOM" id="CLU_045647_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20551" checksum="D5BE1EFFD78DC1A2" modified="2014-06-11" version="1">MFAVPEDERSDRIEPALEAILLVVDEPVTEGLLAQTLGCAVPAVTRSLRGLAAEYDEAGRGFELRQVAGGWRLYTRSEYAPYVERFVLEGQQARLTQAALETLAVIAYKQPVTRSAVSAIRGVSVDGVIRTLLTRGLIEESGTDPDTGGYQYRTTTLFLEKLGLNSLEELPALAPLLPGMDALDDVIAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRY7</accession>
    <name>A0A010ZRY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850726.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2494"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="300" mass="33367" checksum="078CFCD7C43BADDF" modified="2014-06-11" version="1">MTTPALRPGRAPGQGRSAAAFLAPFLILYVLFIVGPALYGLVMSFYDTSMVKSGLSTFAGLQNYIDALGSSDFWSSLWHTFWFTILTTPPLVILALVLALLANRINRGQWFYRLAFFLPYVLPSAVVALIFMWILSPGIGLLDTTLAKIGITAPNWLGSETWAMPALAMTTVWWTIGFNFVLYLAGLQEIPRDLYEAAALDGAGPWQQIRHVTIPLLGRTTTLVAVLQVIASLKVFDQMYIMTSGGPNYSTRSLLQYVYDESFTNYRIGYASAVSMLFFLVVLAVSIVWFRLVRSQQKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS87</accession>
    <name>A0A010ZS87_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118613_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="14337" checksum="4C6F3FCF162579AB" modified="2014-06-11" version="1">MDNLEHEVMTEIRALRDRVRFVSGSLVSRADGLLIAHDTFGVQPEGMAALSATTLGLSERVAVEAGHGRFQEALVRGAHGYVVTYAAGTYAVLTVLATADTNLGRLHLEARALADRVGALVDAAEGTARGTLGGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSE2</accession>
    <name>A0A010ZSE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2689"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="36100" checksum="FAD86243C4A46CFB" modified="2014-06-11" version="1">MALLDTGGGRGKVPATGAEPPAAAVGAAAGGRRRRRTDWREALWGYALIAPTGIGLAVFYLWPVLQTAYLSFTEAGPFGGPSEWVGLENYQELISDPEVGRSLVNTLAYTALGLIGIPIAVVIAALLSRPGLRGVAVYRTFFFLPVVTTPVAVAMIWRWIYSGDFGILNYLLSLVGIEGPHWIADSRTALIAMVIVGIWMGLGYNLVIFIAAVKGIPRHYYEAAEIDGAGPVQQFFRITVPLLSPTIFFVSVVSVIGSLQLFDLVYVLAGGSNQASRANPAFESMETIVYLFYAEAFQNNDKGYGAAIAMILLALIVALTAVQFRLQKRWVTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSE3</accession>
    <name>A0A010ZSE3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848929.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1187"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="26650" checksum="014FA300DED0DA8F" modified="2014-06-11" version="1">MADDVTLEVAGLAFAYPDGRQALFGVDLTLRRGERVALLGPNGAGKTTLVLHLNGIHTAGAGSVTVAGLPVAKENLTEIRRRVGIVFQDPDDQLFMPTVGEDVAFGPANLGLRGAALQERVAEALTAVGMQEFADRAPHHLSFGQRRRVAVATVLAMRPEILVLDEPSSNLDPASRRELAQILQSLDVTLLMVTHDLPYALELCPRSVLMDGGVIVADAPTPHLLMDAELMREHRLELPYGFNPSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSL6</accession>
    <name>A0A010ZSL6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849017.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1258"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_0_11"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="299"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="419" mass="44280" checksum="9E320CF7C5F40A0F" modified="2014-06-11" version="1">MVGAPRRVGVVGGNRIPFARQFGPYARASNQDMLGAALDGLITRYDLAGETLGEVVAGAVVKHSRDFNLTRETVLGSALDPRTPAYDVQQACGTGLETAILVANKIALGQLDWGVAGGVDTASDAPLVLNEKFRQVLLAFNRSRSVSRRLSLLTRLRPGFLVPEVPRNAEPRTGLSMGEHAALTAAVWEVTRGDQDELAAASHRNLAAAYERGFFDDLVTPYLGLERDQNLRPNSTVEKLAALKPVFGDTMTAGNSTPLTDGASTVLLASEEKAAERGLDVQAWLTHSETAAVDFVHGDEGLLMAPAHAVPRLLARAGLALADFDFYEIHEAFASQVLATLKAWEDPIFSKQFDAPLGVVDRAKLNVNGSSLAAGHPFAATGGRILATAAKLLAEKGSGRALISICAAGGLGVTAILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUD7</accession>
    <name>A0A010ZUD7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3405"/>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="24238" checksum="72C58D04F29635AC" modified="2014-06-11" version="1">MIDVAPGVAQLSDRRTQRRWSIALESYRIGVYPVTRAEYLVTTGQPPPAADEGHLPAIDVSWWDAVRFCNALSRREGLSAAYRFGTEDSVEPDASSTGYRLPTEAEWEHACRAGTTGPRYGELDEIAWYRGNSQEQPHPVGGKHPNAWGLHDMLGNAWEWCWDIYDAEVYGSYRVLRGGGWFDEQWSCRASVRRRSHPTLRLDDVGFRLARSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUK8</accession>
    <name>A0A010ZUK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852106.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3505"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="OrthoDB" id="1992113at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19586" checksum="ECBBF1102BE03B21" modified="2014-06-11" version="1">MKPTVVTEEQLLRRIARGDRDAFDELYRRTSPYLAMRLRRRCADEGLVAEVLQDTFLSVWRTAGSFGSVRGAGGAGWLWTIAARRLVDALRARQRVREVPTDELPARSAPPAEDEALAGAVGDELGAALAALAPDLREVLRAMVLDGLTVRETAVLLGVPEGTVKTRARRAKIALRGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW87</accession>
    <name>A0A010ZW87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2355035_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="96" mass="9902" checksum="C29371AD79DB0D05" modified="2014-06-11" version="1">MTNAQVALSHSGSDVREQITSLSAGLRAAHEQGRLDDDLYEAARTEVGTADAAAKDGPTGRGRLVIALKRLSGLVSGFTDLSTAVAAVIALAENRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWA9</accession>
    <name>A0A010ZWA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850839.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2580"/>
    <dbReference type="HOGENOM" id="CLU_049719_0_0_11"/>
    <dbReference type="OrthoDB" id="620979at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021312">
        <property type="entry name" value="DUF2889"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11136">
        <property type="entry name" value="DUF2889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="35482" checksum="8BDDBEF53F41148D" modified="2014-06-11" version="1">MHPRHGIHRPTSGSPGRRPGSVRRTSTVDMLRPDGLPGAVVVDARARDLRTDPDGNPVAAETHLSAEIDYHGGWRLTALCADPPDGRLTELLGASVAAGFRRRVQEVLPEQYADASRLHLLLDDFPVATLVSGVAFGAVPVGGDGPVHLPQTDLCSGWRSDGTIMLEITRDRIVPAVTGPEAPDLASADDLAWHERPPLTPLALRRARRLDVWDEDGVLRLDSLYRDSHVDADGHETVVHEYTLSGRVDPDDFRIVDVVATPRVLPWIECPSAAASAQRLAGRPVRELRPAVRREFTGVSTCTHLNDQMRQLADVPALVWFSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWN8</accession>
    <name>A0A010ZWN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2717"/>
    <dbReference type="HOGENOM" id="CLU_060721_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046249">
        <property type="entry name" value="DUF6282"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19799">
        <property type="entry name" value="DUF6282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="33447" checksum="E455931398828B99" modified="2014-06-11" version="1">MTAVDYPFNPAADEDRATPDPEADALLVGAVDLHQHPGPSPFPRRMSILDAARDASAAGFRAIVAKSHHHSMVTDILALRAAGLDDLPTEVYGGIALNRTVGGLNPYAVELALRMGGRMVWFPTLSSAAHVSHHEHHDTGFPTPEVRLRDNEVISILGENGAVLPEVRDILAVIAAEDAVLTCGHLGVTESQALIDAAIEAGVGRILINHPVFVVGASVEQAAAWARQGVYIEHCAIMYWGKPERRRSLDELLSFIKAVGVEQTILSSDSGQKTNPLPVTLYRRAARGLLDAGLAEADIRRLLGGNGGRLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWW6</accession>
    <name>A0A010ZWW6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851141.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2793"/>
    <dbReference type="HOGENOM" id="CLU_060110_0_0_11"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="301" mass="33368" checksum="AEEE15C4D93FA69E" modified="2014-06-11" version="1">MFDDRVTVAVITHNRRDELLHTLDQLEALPERPRVIVVDNASTDGTAAAVRRHHPDVRLLEPGRNLGATGRNLAAREVTTPYLAFCDDDTWWEPKSLAGAADLLDASPMVTAVTARILVHEAGREPFEDPIVAELRDSPVPRPEWLPGPALGSFLAGATVVRLEPFRAAGGFSPRLWLGGEEELLAVDLAADGWWLVYAEELTIHHRPSPARDATLRRRHGIRNTLWFTWLRRPLGPAVRRTAFLATSVPRDRTSLLAFAEAAAGVPWVLRERRPAPEWVERGLRALEAPQRASGARSYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXJ7</accession>
    <name>A0A010ZXJ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851464.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3031"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_5_11"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="20331" checksum="6C6BFE19131F85E7" modified="2014-06-11" version="1">MTTVALYATDTMADWEYGYLVAGLAMAGGELRVFGAPGVTEVRTMGGLRLLVEPAPEEFDALVLPGADTWETGHDEVLELARRSLDDGVTVAAVCGATFGLARAGLLDDRAHTSNAPDYLPDYRGAHRYREAAVVTDRNLITAPATAPIDFARALFEELALFPAPVVEAWYGLYTTGERRYYEQLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXL8</accession>
    <name>A0A010ZXL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3052"/>
    <dbReference type="HOGENOM" id="CLU_000022_31_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1957"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="2312" mass="245821" checksum="100E30C7106E51B0" modified="2014-06-11" version="1">MEPLAIVGIGCRLPGGVHGPDEFWELLMSGVDTVGEVPADRWRTERFYDPDPETPGRMSVRRAAFLTEPVDRLDAGFFDLTPREAAIVDPQQRLLLEVTWEALEDAGIPPSALAGRAVGTYIGNAMVDATHLQVSEPNLEMIGAHTATGASLTLLSARLAHAFDWRGPCLSIDTACSSSLVAFHYACGVVASGECEVAIAGGVNVMLDPASSIVLAKGQFLSPDGRCKAFDHRANGYARGEGAAVVVVKRMADARRDGDRVYAAVLGTAVNQDGRTPGITVPSRAAQRAAVAAACDTAGIEAGSIGYFEAHGTGTPVGDPIEVAAIGDALAGSTARHWIGSVKTNIGHLEGASGVAGLIKAALCVERGLIPPNLHFERPNPAIPFDTLPLRVPTKPVEFDPAIGPRRAGVNSFGFGGTNAHALVEQPPPGPSPEPDPATGPFVLPVSARSAGALRALVDGYAELLAADDAPALHQVCRGASRGRSHHPLRTSVVAADSASAAVALRALEIPDKPRRAAGSGAVFVYTGMGPQWWGMGRALLQEEPVFAATVRECDRVLARFGISMDDELRRDQETSRLTEPLYAQVGNFVVQAGLTAVWRSWGVEPSAVVGHSVGEVSASYAAGVYSLEDALTIGVQRARRTSAAGPGAMLAVGLGADDLAPYLVDGVSVAARNSPGTSTLSGQRAPVALVAERLRDAGVFVRELRVDIAYHSDVMDGIRVPLLASLDGLRPRAATLPLLSTVTGDWLDGTTMDAGYWWRNVREPVRFAEAIARAAATGPAAFLEVGPHPVLAPAIREVVIDAGADVPVLASQHRDRPGARTLREALGGLYVAGGEPDWARIHPGERRPVDLPTYPWQRERHWLESPYARSARLGDEGWLMAGRKLPTPLPSWDTELSAAEFPYLADHRIADTVVFPGAGYIEAALAAFGDRTPCVLADIVLDRTLALPPKCVTTLRVTHDPLTREVTMHARRSGDDSGWSRHAGLRLATLADPAPPPAVATDPPVGWTEMAHEAVYAHLAGAGLPYGPAFRGIERLWWRSGEVVARIDVGRVDHSGHRLHPALLDAALHAMLVGARPDGTSRTFVPVRIDEVRFHRSPGRSLWVHGRGRTGPDSVVGDLTLITDDGAVVAELIGMRAQALSDSAATPGQTTEELYYEQVWRPEPAPDDGTAEGSWTVVGASPLAVGIADGLAARGGVVRRVVPEGDWSTGLSAGTRGVILVVDPDRADDRACGACTRPLELIRALHEPTSLFLVTSGAQGRAGDGPPDPFSASVWGFGRAVNAEHPELRCRQIDADAPDDALIDELIHSGADDVLLRSGHRSVLRFQRAEARSPLHHVTVGTADTPVRLRTGGSIEDIRIEACSRREPAPTEVELAVAYTGLNFKDVLKATGLLAREAMENTHSGPAVGIECSGTVVRVGAQVTDLRPGDEVFAVSKGLFSSYVTLDQVHVVRRPASLSLAESATLFPVVTAYVALVHLANVRPGERVLIHSGAGGVGLAAIRIAKWLGAEVFATAGTPERRDLLRAEGVAGVATSRTTAFADEIRAWTGGEGVDVVVNSIPGEILERSLELLRPLGRFVELGKADFAADRALRLRPFNRSISFHAFDYDRLLLERPEIGRRYMRDVVRLFDDGAIAALPMTEVPLEAAATAFRAMARREHVGKLVVRIGDQQVRVPASSLPAVTLAPGTYVVTGGSSGFGLATARWLADRGARHLLLLSRRGLASAEAERTVAELRERGVTVRIAPADVTDRAQLHRTLEEARRTLPPLRGVVHAAVVYDNDLLADMSAEHFLDATAAKADGAWNLHVETAPDQLDLFILFSSTAAQFGGSKVGPYAAANEFLNTLADHRRALGRPAVAVGWGAVADVGVAARFDQIGDSLARRGFVGSTADRLLAELTTLLRTDPARASIGAIRWDRWVRANAHLATLPRYADVAPADASEHSDAALPDRLRAGTREQRLALLPDLVEDLLGLLTGLPKEQVAEQGVVSLDSMMSVELRVLLRDRLGVSVPIVELLQNLTAGRLVEVVADVLEGAAPETALPVVHELTSSDGLTVYGHLSLPPGPGPHPAVLVCPPDPGGVLDAEGRYRRIPEHATLVGAGFAVFSVDRRGALGHGDEYAARTDVGGLEVDDVIAAAQFLIRRDDIDPDRLSIYGVSRGAYAALLALTRAPGLWHRGVLAMGFYDPGRYVAAERAARPTTSRLIADATWDALDVLAASADRLPLRVLDRVTAPLYVLHGAADEVTPVEHAYDLAERAEAAGGPVRLVVVPGLGHDIDHQHDAWSRLWPDLVTFLDDGVTTGRPGPYHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY47</accession>
    <name>A0A010ZY47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Short chain dehydrogenase/acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3236"/>
    <dbReference type="HOGENOM" id="CLU_000022_35_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1233" mass="126559" checksum="6B30190EF0C7B608" modified="2014-06-11" version="1">MLAGFSGAVREVMWGDDSGALARTGFAQPALFAVEVALWRLIESFGVRASVVAGHSIGEIAAAHVAGVLSLADACVLVSARASLMEALPEGGVMVSVRASASAVTPLLTEGVSIAAVNTPGSVVLSGEEPAVAAVVEALGAKSTRLPVSHAFHSALMDPMLQPLTEVAAGLAMTPPVVRLLSGVTGAAVDRLEPSYWAAQAREPVRFADVVAGMDDVGVILEVGPDGVLTALIADDPDDRAVATLRKDRPEVAALLTGLAGLFVRGMPVNWAPAFAGLRPRVTEVPTYPFERERYWPTAAIRPGDAAGLGLAAAGHPLLAAAVDLPGDEGAVLTGVLSVATHPWLADHRIGGVVMVPGTALLELAVRAGDQIGRPRVDELTLVAPLVLDESRATVVRVRASATAVDVSARPADAPGAPWTRHATGTLSPPPGTTPPSAAETAPSANADGAAPPRPADAAPPRPADAVPARPADAVEIGLDGLYDRLAGDGLAYGPVFQALRAAWRDGDTVHAEVELPADEAGSATAFGIHPALLDAVLHAGALLADETGDGPRGLPFVFSGATLHAAGASAVRATLRATPTGLRVVVADVLGAPVLTIDNLVLRIPEAAPPPAPASDPIHGVDWEPVAAVPADGAPAWVVLGPDDLRLGGREITSPADLGDARLAVLAIQPAESAALPEAAHTTTVNVLAALQNWIEQTQVPLLVVTRHAVGVDAGDPVDLAVAPVWGLVRAAQAEHPGRFLAVDLDRPEDFTTLLPAIAGVLATGEPQLAVRKNVIRAARLAALPAPPADKPADAATGAHAWDPDKTVLITGGTGGLGAILAEHVVTSWGMRRLVLASRSGPDAPGAAELLERLKGAGADVRIVSCDVTDRASVERLVADARPLTAVVHTAGVLDDAMLTSLTPDRVTAVLRPKIDAAWWLHEATKDDDLAAFLLYSSVSGVVGAQGQANYAAANSFLDALATTRPSTMALAWGPWAADAGMTSALSDAAIARLGRSTMPPLTPEQGLALLDTAVRSDRPLAVLTRINPTAPTAVPPILRRLVTPPRRTAATAVTTDLRAELAGQDPIDQRQRVLDLVRAGAAVVLGHTTADRVRADLEFRQLGFDSLTAVELRNQLGTATGLRLPSTMVFDYPTPDKLAGFLLDELLDDLGPAVAPLTAELDRLEAALAAAGPDEADRAGVPARLRQLLNRLTAAPAGAGAGAGVTEQIHAASTAEVLAFIDNELGRATNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYH8</accession>
    <name>A0A010ZYH8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851917.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3361"/>
    <dbReference type="HOGENOM" id="CLU_1494754_0_0_11"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20651" checksum="FE9D607615C3B5D2" modified="2014-06-11" version="1">MEFLCYHRDRPGSGSLRDELLEEHWAYMDRYGARLIARGPILTGDGSVATGSLHIVDLPSAAAARAFAFAFEEPNYQAGVYRDVLVRRWRNGLGRSMWEFPGGATGDNRYLVLAFGAGRAVDLALPAPVDQLIAYGPMLSDDGVNWLGTAMLVRLPDQESARALLSPEHYAEIEVHDWQFGGRRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYL7</accession>
    <name>A0A010ZYL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3402"/>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="5">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="495" mass="54796" checksum="0700CC16093EF61D" modified="2014-06-11" version="1">MAAGVRGQRAECPGCTASSTRVHSRYRRRIADAPTAGRSTQIWLRVRRFFCENTACEKKTFVEQVAGLTRRWARCTDSLRRMLTAVGLALAGRAGARLTAVLGMPVSRHSLLRLVRGLPDPPVSPVSPVTVLGVDDYAVKRGHHYGTVLVDCQTGKAIDLLLGRDADPLAEWLQAHPKPVVICRDRATAYAEGAATGAPEAQQVADRFHLWQNLATAVERTVIGHKRCLEEPAVPAAETSRSPATEPTGAMADRRKANHALVHDLVAQGASFRQIAEHLGWSQRTVARYAHAKAWQELMVGQKPRPSLLDPFIPYLRERIDQGCLRATRLHREVTTQGFTGGYGIVRAFVEQHRMKPDLERVRRPASVREVTGWICRHPDNLVEHDSQRLQAILERCPELNTAAELVRSFADMLTHLHGHRLGTWIASAQASAPSPIARFATSLTNDLAAVTAGLSQPHNSGPVEGNVNRIKMIKRQMYGRARFDLLRKRVLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYV1</accession>
    <name>A0A010ZYV1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852149.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3523"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="25392" checksum="82269B4B7976E0D3" modified="2014-06-11" version="1">MDFENLVALVTGSTTNGAGRATARLLAERGASVIVSGRDSERGSTVVREIEAAGGTARFVRADLADSASVQGLAEAAGPVDVLVNNAGIFPAAHTLEQETEPFDLLFAVNVRAPYFLTKALLPTMIERGGGSVVNISTHAVRQAEPGLGVYSGTKAAMESFTRTWAKEFAASGVRFNTVAPGTFLSDGVVNASGRETVEAIGTKNSVLGRAAQPHEIAEAVAFLASPRASYITGATLAVDGGRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ28</accession>
    <name>A0A010ZZ28_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="282" mass="28967" checksum="F5EC237E5E958AA4" modified="2014-06-11" version="1">MTEAAMTEAVVTEAVVTEAVVVGPMRGAGWLAANVATVTGRNLRRLVRVPTLIAFATVQPVLFVLLFTYAWGGAVHPPGVTRYIDYALPGIWVLSLAFGASQTGVAVAEDLATGMIDRFRVLPMARSAVLIGRTVADAARNLFVLALMTGVATAIGFRFHAGPAAALAALGLALGVGVAFSWIFALLGLLVHDPESAGVGGLLVAVPLVFTSSTFVPIATFPGWLRAFASVNPITLTVDALRALCLGGPTAAHAGQALACVGGLLAVAVTAAVRRYRHTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZY8</accession>
    <name>A0A010ZZY8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570656.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3944"/>
    <dbReference type="HOGENOM" id="CLU_295070_0_0_11"/>
    <dbReference type="OrthoDB" id="633696at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041173">
        <property type="entry name" value="LodA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041168">
        <property type="entry name" value="LodA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18417">
        <property type="entry name" value="LodA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17990">
        <property type="entry name" value="LodA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="567"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1026" mass="107733" checksum="21CBC2F662361864" modified="2014-06-11" version="1">MATTYRIHPAIGVARLGNSPDAYFVGPERPGERPSPGTFKDEQLRIKRQAARFRIFAHHDDGSTEEITSAQARIGWTVHLANRKATNPAARNDEPDADLVIDPGPRTVEGPDQRAAFDTGVIRFAGQRPATVPLGEVRTEPDGRLLVLGGSGTSASPGGNLVGSLWNPGWYDDAADGPVTATLTLPDGSTPPVEGAWVIVGPPKFAPHQDSVVSLYDRLLSRMVALNLVPAPAATSYTADIYPILQRAADVRWVQSVGRAHGWAHPVTEQRLVDRIVGRLRPAGDMPLLAGDDSALTDVQTAHVARWKSGQYAKDWNGVPAVAAEVTPDGLDRAALEACVGGAFAPGIEAGGENDQPILLSTYTAAFRLDHTTLAPGALTVGMSLPWQDDFSACGQNWWPAPRPNDVFERVGATAAVPWDREVGSGDEMVVHWHTLGFVVPQGDQQVETEHTDAPAITLLTPHLDFADVEQGLLGMIREEVLPIRFSVRTPTTLVLTAPAHPQLTAVVAEVTVDPEQDPTAEFPIAYRTGVAPSAVPTQTFTVTEPSTGRTWPISVDANTVARRPAATALVLDRSGSLTAAGRGTQLRKAAQSLANLLPDGDGVGIVGFAADAEVLQPVLPLDAATRAASLGVLTGPGLDPSGKTSVGDGVSAGQNLLEAATGFGPKALVLLTDGVENAPKPVEDVIGETTDPVHAIEIGPPNSIGVPVLGALAGNTNGTFRTSTDTALGASTMQVLAEVTGSQPVTTANGRLAPGAVRRIPFQLTEADSGIDVLLLTPTPDAVDFRLQTPIGELIEPWQAIAAPSMRFGIAGGVTWYRLALPVQQRPGRFERAGTWHVVITPGRPRTEPAPGTDRSVLRGATATRRTAMAAVPEPAYRSELERAFAVISAPVATQRAAVAPAPGLAYALRVHAWSSLSLLADVTQFEFAPRSPVELSARLTQSGRVLSTGVSVSAEITPPTGAVTRTALTGDGGFFTGNFTVTAAGSYQVRFVAQGKAANGQPFTRERLSSAAAWVGETRPPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A018</accession>
    <name>A0A011A018_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_4013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570677.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3987"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_11"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="PTHR43149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="27400" checksum="7279769B85FB349E" modified="2014-06-11" version="1">MTDVVRVTVDVDGGIADVRLARPEKRNALDPAMFEALVRTGERLRTEPGLRAVVLSGSGPDFCAGLDLGAMSALGRGDRLTAVVDLPPGDGPAAALGQRAAYVWAQVPVPVVAAVHGNALGGGLQIALGADIRIVAPDAVLSVMEVRWGLVPDMTGTQLLPRLVGPDTARELVFTGRTVTGTEAAAIGLATRTADDPLAAAFALAREIATRSPDAVRAAKRLLDLAERVDLATGLAAEQTEIAALIGTPNQAEAVAAGLGKRAPNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAP6</accession>
    <name>A0A011AAP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.108"/>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="8">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="598" mass="63010" checksum="F6D706BD6AFFEE8E" modified="2014-06-11" version="1">MVGVHFETTDLMAVFGLIIGAATVAGAARKLRISPPILLVLVGLAVSYLPGIPDYTLNPEIILALFLPPLLYSAAWRSSSRGFRLNKRPILLMSVGYTLFSTVLVALVAYWLIPSMPLAAAFALGAIIAPPDAVAATAVGRELGMQRRYLQVLQGESLVNDATALTAYRAAVAAAAGGITLLEGGGIFVAAAGGGVVLGGLFGFLLREVRRRVTSAVLENTLNLVVPFAVYLAAESVHASGVLAVVITGLYLGNTATDTSPQARLQAESSWEVIDFVLESIVFALIGLQLPAVIAELEGQNVASVAWWSLAVLLVTIAGRFIWVFSSSYLIRFFSPAVRARTPSPYWPTPTVSSWAGMRGVVSLAAAFALAHDFPARGLILWLTFVVVFGTLVIQGLTLPGLIRRLGVGGTDDMSDRLAEANAQHQAARAATERLDSLVSSAPHPPSDQVVGLLRHYSEYRANSAWERLGGGLSHGGKETPGAAFRRLRQEMLQAQRETFMRLRQVGELDDEVMREMVRELDLEETMLDRHGEDPEPKGHKPPVTSGDSSGSSGGSSGSSGDSEAPAEGAGGGAAGDRRGVADPTASPAAAADGTNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABC4</accession>
    <name>A0A011ABC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847858.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.313"/>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_11"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="247"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="506" mass="54165" checksum="B0C5D3388182C2E0" modified="2014-06-11" version="1">MAHEIDQRFLALPRTALADAALQRARDLGASHADFRLERLRSQGLSLRDGRLEGSHDGEDVGFAVRVVHDGAWGFAAGVDLTVDAVVAAASTAVQVAKVSARMSTERIELAAEPVYQDAQWISSYLVNPFDVPETEKVALLAEYSQRLLGAAGISHVTAGLSQVLEGKFYADTAGTVVTQQRVRVNPSIQALSVDAESGRFETMDSIAPPVGRGWEYLTGTGWDWDTELASLPSLLAEKMAAPSVEPGRYDLVVDPSNLWLTIHESVGHATELDRALGYEANYAGTSFATPDQIGTLRYGSGVMDVTGDRTVEHGLATVGWDDEGVAGQSWDIVRSGTLVGYQLDRRMAALLGAQLGVSRSNGCAFADSPGHVPIQRMANVSLAPASSDVSTADLISGVERGIYVVGDKSWSIDMQRYNFQFTGQRFFEIRNGRLAGQLRDVAYQSNTLDFWGSMEAVGGPSTWVLGGAFNCGKAQPGQVAPVSHGCPSALFRDVAILNTVQEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACL7</accession>
    <name>A0A011ACL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848534.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.794"/>
    <dbReference type="HOGENOM" id="CLU_006462_0_1_11"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="11"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="504" mass="55499" checksum="29AA9C1513BA3A8C" modified="2014-06-11" version="1">MTWWRSAAIYQIYPRSFADGNDDGVGDLAGVRARLPYLASLGVDALWFNPWYPSSGADGGYDVIDYRDIDPAYGTLAEAEKLIAEARVLGLRTIVDVVPNHVSHRHPWFANGQRELFWFRDRPNNWTSEFGGSPWSQLPDGSWYLHLFTAEQPDLNWTHPVVREEHEDVLRFWFDRGAAGVRIDSAVLPVKDPALPDVGPAGPHPYVDRDELHDIYRSWRAIADSYDAILIGELWLPDAERFAKYLRADELHTAFNFDFLACPWDAARLRASIDTTLAAHAPVDAPATWVLSNHDVTRVVTRYGRADTSFSFEAKRAGVPSDVAMGTRRARAAALLAMALPGAVYVYQGEELGLPEYEVPADAIRDPMHARSGGIDPGRDGCRIPLPWSGTAPPYGFGSMPTWLPQPAGWGSLSVEAQDGAPDSVLTLYRDALRLRRRFEGGLRWLDSSPGVLTFARGSGETCTVNLSSAPVPLPPGDVILTSAPLTDGQLPSDAAAWVGLRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADJ7</accession>
    <name>A0A011ADJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine N-alpha-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidine trimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">egtD</name>
        <name evidence="5" type="ORF">CryarDRAFT_1191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:38471"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. EgtD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848914.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1171"/>
    <dbReference type="HOGENOM" id="CLU_049766_1_0_11"/>
    <dbReference type="OrthoDB" id="775492at2"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02037">
        <property type="entry name" value="EgtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032888">
        <property type="entry name" value="EgtD_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="4">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-histidine binding" evidence="3">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="35631" checksum="16C7D6F581D8AD95" modified="2014-06-11" version="1">MVAATLTVENHLPADFIASTLRRDVVTGLTAEPKFLPPRWFYDDRGSVLFDEITRLPEYYPTRAERSILRAEAAEIAAASAATSLVELGAGSAEKTHLLLDALRATGSLRTYVPVDVSDGALRTASANLLWDYPGLAVHAVVADFERHLGLLPVDGHRMVALLGGTIGNLAPDTRAQFLGNVRAALRPGETLLLGTDLVKSPDVLLPAYDDASGVTAEFNRNVLNVLNAELGADFRAEAFDHVARWDAEHEWVEMRLRAQQAMRVRIPAVDLTVDLHRGEEIRTEISAKFRRERVAAELDAAGFGLTRWWTDEEGRFGLSLATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADS2</accession>
    <name>A0A011ADS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, PurR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725877.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1248"/>
    <dbReference type="HOGENOM" id="CLU_017436_4_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="424"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="483" mass="50284" checksum="E4E5F0693B05033C" modified="2014-06-11" version="1">MLLGDLLGTADLGLRPLVLPPGADSRTIVDVYTTDLPDPGRYLAGGELVLTGLVWWSPEAVETFVDAVVVGGAAALGAGEAALDGVPDLLVDACRKRGLPLFAVPASVSFAEITRRVLAEGRPARPVGRRLLAVLAGRAGLNRLLDVAAAELGEPCVVLSPVAGVIAGAAPPEQTELTRAFLAAPRLPTAVGKIRLLAADAPDRHRTVSWFVACPAEPGNADATALAEELAGLVALERARVDAGRRAERRLADQVLRALTAGQDASAELRVAGIAPGTPVKILVSAGKATTLVDEILRTAVPDPVVGYRDGATLAVVPRAGDQLADVLKAGFAAVRSGLGDLRLPTGLSGTVPAGPALFAALEEARHAAGLAAARAEPAAVVTADEIDSHMLLLGSVPDEVRRAYRNRVLGPVLAYDSAHDAELVATLTAFLDHAGSWSRCAEVLHLHVNTVRYRIAKVEQLTNRNLSRLDDRVDLFLALRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEQ6</accession>
    <name>A0A011AEQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase and lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569903.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141027_0_0_11"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="15232" checksum="C58BDF3B7BE20857" modified="2014-06-11" version="1">MTWSHRHSELTTATPAQLWTRWTTAGSWRIDDPGVEWARFDGAVVEGATGVVKTHGAPARTIEFTRVEPGRAMDFTIRLPLATLAITHDMEPAAGGTRTTHGVVLDGPLHRVYALLLGGTLARGLPTVVRNVTAGALRDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF24</accession>
    <name>A0A011AF24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_16_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="10985" checksum="188520A6AAD331AD" modified="2014-06-11" version="1">MSIDPYGDRAVYKQLSDLLAAGIRSGEYQPGTPIPSESKLMTRHNVARNTVRLAMGVLRERGLVVTRHGRGTFVCGEENDQEQDQPSTSRSRAANSSGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFD3</accession>
    <name>A0A011AFD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1145697_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="24969" checksum="0E8F1CF8585AAB6D" modified="2014-06-11" version="1">MGCRRTRCLGGVARRWRGGATVASANRGVRGGERWRAGECGSTRCGRGEHVRRRAGGPAGRRGRSVPRRSGSVPRTGRCEWIVGCGPDPAGAADRVAGRGTRPGCVAVRGRTGAEGGGQLRGGARRSVVRRGRAVPRRSGSVSGARYRQWARGSGRDPSRTAGPATSRRTRPRLRRPRHRPSRGRRPRGPGSGCAGSGCAGSGRAGSGKPGPDPGQTCPGPFDSGPAWSGPGQPGSVCSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFL0</accession>
    <name>A0A011AFL0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849878.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_13_3_11"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="14421" checksum="1FAC42C83616E2F0" modified="2014-06-11" version="1">MIDKIAWIHLRDGRILSTRSHGKDVWYLPGGKREAGESDLDTLVREIDEELSVRIDRASARHLGTFEAPAHGHPVDVRMTCYTADHSGEFVAANEIAEIGWLTMADLGRISPVDRLIFEHLHDAGLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGD1</accession>
    <name>A0A011AGD1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850239.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2142"/>
    <dbReference type="HOGENOM" id="CLU_055769_1_1_11"/>
    <dbReference type="OrthoDB" id="1540164at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="284" mass="30597" checksum="F143BC3A087F7C21" modified="2014-06-11" version="1">MGRTPTEQLLALFEPHRLSPTQRRIAQHLLDHLAEAAFLSSVDLAGRVGVSQPSVTRFAVALGFAGYPDLQKALRPIAMRALADRPDPETVRRNELQSAVDAEIRNLEALRQSLVDPSRVVALGRDLAASMPLTVLGARISAPLADYFGYAARRIHPDVRVVTSGGSAVYDALLQSQEAGGRWVFAFALPRYAEETIAALRFARELGFRSAVVTDAPIAPFADDVDVLLAAGVGTRLVFDSYAGPVALAAVVLQAMADADPARTQARLEAYEGMAERAGYFTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIS3</accession>
    <name>A0A011AIS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078205_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458541" evidence="1">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="36"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="26052" checksum="41048183ECEDE997" modified="2014-06-11" version="1">MLVACVLVVGGCAGSGPRAADVVATAPTPGRWTVTALGDSVTAGSGCDCAPFVDHYAELTHRATGFRVTADNLGVPGQTSEQLLATLTGDTDTTRRVADSDIVIVTIGANDFVPALDDWASGGCDLACFRTVADSVRTEVGAIAQRIRAVRGGFPTAILVTDYWNVFRDGDVAQELGAGYDQISEQVTRLADTAICDGLVDTGAVCVDLYAPFKGDGTGDPTGLLAADGDHPNAVGHLLIAETLAAEGWKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIU7</accession>
    <name>A0A011AIU7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851456.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3025"/>
    <dbReference type="HOGENOM" id="CLU_069356_21_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20929" checksum="C03CA4A0E84180D0" modified="2014-06-11" version="1">MRQNPARRTALLDAAIEVLARDGSRGLTLRAIDKEAGVPTGTATNYFANRDELLAQVMRRTRERLTPDPEALAATMTQAPSHALAGELMRQLLDRQRADRSSNLAMLELRLEATRRPDLYAELSGFLAAEHRELVDYHVAAGLPGDRTGVALLYFAMFGLVVDSLTMPAIVEGYDTDALIQELVEHVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ65</accession>
    <name>A0A011AJ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3164"/>
    <dbReference type="HOGENOM" id="CLU_2057476_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="12660" checksum="00798B0CBE9D3CF2" modified="2014-06-11" version="1">MPALVPDRARSGLAFGLAALDCHGRVNDRLILAMLGWVGGQRLAVREESGLIVVAADSGGAFRVTRQGQDVNTAPARLRGPGERANAELKSWKVHRMIRSSPNQAGPLINAVQTLILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJW5</accession>
    <name>A0A011AJW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851935.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="32617" checksum="5CE9C1A8ABCDDD6E" modified="2014-06-11" version="1">MDLINEVVARARAGRAVARRSRYAGDWATRFPAVNGSGLHVVQRGSLWLIPENGDPVSLRAGDAVFVPHGPPHGFSHAPAPFSSLSETGAWMPGGDAFDVEFVSCCYHLDRGQVHESLTGLPDVITLTIDGHQHPQLPVLAELLGDHADGAGSGNDIGLAAVVDLMLVHLLRAWRGLQDEQVRRRTPDPQIAHVLKAVQDEPYRAWSVRELSDRTRLSRAAFTRRFTAALNETPSAYLTRRRLEQGAHLLRHTELPLASVAEHLGYATEFSFSTAFRRHYDIAPGRFRSQHRVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AK88</accession>
    <name>A0A011AK88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3364496_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="35" mass="4290" checksum="F522F9C59B4032A5" modified="2014-06-11" version="1">MHRYWLRGLNELWVEVKAWAPRPVRPRRPGMTQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKC5</accession>
    <name>A0A011AKC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CryarDRAFT_3605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570508.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3565"/>
    <dbReference type="HOGENOM" id="CLU_000404_1_0_11"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG82421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="791" mass="87250" checksum="C0298B44FC53D26E" modified="2014-06-11" version="1">MTTAEVAPETPVQRRPQMHVTKRNGDAEPVDVNKIVKAVERWADDLTDVDPLRVATKTISGLYDGATTAELDQLSIQTAAEMIGEEPQYSRLAARLLAGYLDKEVRGQGIASFSQSIALGHEQGLIGDETAAFVKKNARKLDDAIDESNDLRFEYFGLRTVADRYLLRHPHARLVVETPQYWLLRVACGLSTTAKEAIGFYRLLASLAYLPSSPTLFNSGTRHTQMSSCYLVDSPKDELDSIYQRYAQVANLSKFAGGIGIGFSRVRGRGALIRGTNGQSNGIVPFLRTLDASVAAVNQGGRRKGAACVYLEPWHPDIEEFLELRDNTGEDARRTHNLNLANWIPDLFMRRVEEDGLWSLFDPDEFPDFPDLWGEDFERAYEAAEQAGREVRKIKARDLYGKMMRTLAQTGNGWMTFKDASNRLANQTADKKNVVHLSNLCTEIIEVSSDDETAVCNLGSVNLAAHVAGTDLDWEKLRATVRTAVVFLDRVIDINFYPTPQAAASNPRWRPVGLGVMGLQDVFFALRLPFDGADAKALSTKIAEEIYLTALEASADLAEQFGAHPAFADTRAARGDLQPDLWNVETSGERWDALRTRVGTTGLRNSLLIAIAPTATIASIAGCYECIEPQVSNLFKRETLSGEFLQINSALVRELKDRGLWTAEVRNAIKQADGSVQGITALPAEVRELYRTAWELPQRALIDLAAARAPFIDQSQSLNLFLASPTIGKLSSMYSYAWKTGLKSTYYLRSRPATRIQQATVAVAAPSTPEPEISEAIACSLENPESCEACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKW0</accession>
    <name>A0A011AKW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852520.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3762"/>
    <dbReference type="HOGENOM" id="CLU_076645_1_1_11"/>
    <dbReference type="OrthoDB" id="1966598at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="201" mass="21829" checksum="B069B2C6CB467819" modified="2014-06-11" version="1">MGSAELDELIVADAEALRDWLAANGETSPGVWLALTKKGGTVTTLTWQQAVDEALCFGWIDGQARKRDAEASWIRFTPRRARSSWSQRNVAHVARLESEGRMRPAGRAAVDAAKADGRWAAAYAPPSEAEVPDDLLAAIAAVPAAQAMFDVLTKTNRFSLIYRVNAVKKAETRERKIGELVAMLARHETFSPQKAKPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL60</accession>
    <name>A0A011AL60_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852624.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079845_0_0_11"/>
    <dbReference type="OrthoDB" id="1875436at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458564" evidence="3">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="32711" checksum="EC682B57C8A2D3F9" modified="2014-06-11" version="1">MSTRRARSRTSADSSSVPTSPAAALRTTLAVVSPVALITALLYYFGWVRVSTQAQALGYDATIVGLTDQSYVVRSIAVLFYPLLTTILAAIAGFAVHRAVLRRATRSSRWRERTIWFGTALTWSWPVWLGMCGGFLAVPALRPAAVPVTLTATCLSVLYGGLLVGRLSRRELDKGIRGCVLALLALALFWDTERLARAWGEGDAGLISAGLKPVPDVTVYSTTALNLTGIEPSTVPSGAYRFRYHGLRLLHYTADRYVLTGATGQAADRVYVLRDRPAVRFELSRPPGARAGPPPQAGVVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALJ9</accession>
    <name>A0A011ALJ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, histidine kinase/DNA gyrase B/HSP90-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701665_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="43529" checksum="F996C559E5CE0A68" modified="2014-06-11" version="1">MPHRCGMDRPPGPCQTAGVDSALAVDLHRRIRAITTGVILLARLGTLVMVALSIASLAQADGFVNRPLATAVYLVVAGWNVVFLPAVARCEPIPRAVLAGDVAVTSAAAAVLPWTLTAEAFATVAVPDFEPVAVSSGVAVALASASWPATVGGCTALAAGYALPTPHDYPDLASTANIIGWQVVTAACCCLFIRRLRAVADAVDTATEQVITARERLAARRSQNEERIRHFQEQLRRHRALHDGPLRLLTAIAGQGPAGHPDERVRRQAAISANVLRGVTPDDADGTLTELSLALIEAGNDSAAQGLRVEYHFANLPDTLPSDVLHAFRHATGEALANVARHAGSSRVRLTALADRPSAAVTVAVVDQGTGFDPETTALGYGIQQSITARMVEVGGAASVDSHPGEGTRVDLRWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFM6</accession>
    <name>A0A010YFM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.48"/>
    <dbReference type="HOGENOM" id="CLU_1452197_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="19774" checksum="B7EFDF486BA65FDD" modified="2014-06-11" version="1">MSTDVQPTDADAPDERAARALAMQASPEFVELRRTIRRFIFPMTVAFLVWYLLYVLLSAYARDFMASKVVGNINVALVFGVLQFVSTFLIAWLYSRYASQRFDPLAEQIKAELDAESAADVPAATTAPTAATTTTTATTTTTATTAEAAPAATTAPTTKPAPTASETKADKDAEPTKPAASGEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFT4</accession>
    <name>A0A010YFT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter periplasmic binding protein, thiB subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051571859.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.103"/>
    <dbReference type="HOGENOM" id="CLU_026974_6_1_11"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457865" evidence="1">
        <location>
            <begin position="27"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="351" mass="37245" checksum="15BEF9D77DB1ABB9" modified="2014-06-11" version="1">MRAPRLLAAVLLTAAVAACSSSSDKAATDSKTVTLVTHESFAVSDEVLAAFQKQSGLTVKILRSGDAGAVVNKAVLSKGNPQGDVLFGVDNTFLSRAVGAGVFAPYEPAGVGNVPTALQQGTDGKASAVDYGDVCVNYDKAWFTKKGVQPPASYADLIKPEYKNLLVVENPATSSPGLAFVLGSIAVQGESGWKSYWEKLKANGALVVDGWEEAYQQRFTVGSQGKGDRPLVVSYASSPPAEVVYAEKKPKDAPSGVVTDTCFRQVEYAGLLDGAANPTGGKKLLDFLLSPAFQKDVPLQMFVWPSVTGTPLPAEFTKYAALPTKPLTLPADQITKNREPWIDEWTQTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFW4</accession>
    <name>A0A010YFW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemoglobin-like flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.135"/>
    <dbReference type="HOGENOM" id="CLU_342481_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="3">
        <location>
            <begin position="49"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="binding site" description="distal binding residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="827" mass="83774" checksum="DFD5F876DDC11E05" modified="2014-06-11" version="1">MTGNHRPDSATMSLIRESRTALAARPVDLAAAVYRHLPSFAPRTKELLAADVRLHGDRLVRDLLRAAEVLDSLAALEDDLRRLGAEHTSQLGVRSELAEHLPYLGQALVRAVRELFPNSEGGPFGSAWLEVFEWLADEMMQGARPGVEEPSPAYWRSYVGEARGSGLGEVRGSGPGEARGTGPGEAARGSGPVEAEAGFWPGALGEPGVVRGSHGAEVDPRAGSEDEQASSLRPGGVGETAGGVDPARDLTISFDRAELLERLARLEEIDASRPVSPAASPGVSPAVSPAAGPVAAPGPHPVGPMPPVMRPVSPAGPGPIGSVPSEVRPVSPAGPRAAGPLPSAAGPLPPAVGPVSSAVGPVSSAVRPAGSGVAGAVSPAVRPAGPGVAGPVSSAVRRAGPGGAGSAPSTARPGEPSAARPEETRAAGAVPSVARPVSPAGPGVAGPGVVGPGVVGPGVVGPVLPAAPPGRSEGAAVRSEGAAVRSEVSGARSSAARPELSARRPEPSGKSPVRSEPASVRPISPAPRGGGPLPRPVSPAAAGRTEPPVGRPISPAGPSGRAAVVRPVSPAGPAGQAPVRPVSPAGAHAAEVKATGAHTTGAHTTGVHSAGAHAEGAHAAEESPRRGGRPWRARNPWSWGSRARKAETEPQSEPWPPPPRIDPSMYDSPPEVAPPSGRQHPESPSPDHQAPGPQEAELQRLEPQHLDPPHPGPRHPESRHPEPRQLQPQPPEFRRPEPQHLEPQHLEPQHAESQVRAVEVGGTAVGESAVSPPPQDESVESGAVSHPGGALRGVGTGWPRASAHRPVRPVRSAESNPPDLGDAPAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGE9</accession>
    <name>A0A010YGE9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ORF">CryarDRAFT_0343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.328"/>
    <dbReference type="HOGENOM" id="CLU_002929_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="199"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="829"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="871"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="946" mass="104206" checksum="6851BF593CE8E55C" modified="2014-06-11" version="1">MSAPTTTAAAAKRGRRTGTAAGDDGLRLVIVESPAKAKKIADYLGPGYVVEASIGHIRDLPRNAEDVPAKYKGESWARLGVDVDREFAPLYVVSPDRRAQVTKLKQLVKDATELYLATDEDREGEAIAWHLVEELRPRVPVRRMVFHEITRPAILAAVANTRELNLSLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRIVVERERARMKFRSAEYWDIRGHFAVSESVPGEPGDFLATLVGLDGDRVATGRDFEPTTGQLKTEVRGDVIQLDEAGARGLAARLEGAAFKVVRVEEKPYRRKPYAPFMTSTLQQEASRKLRFAAEQTMRVAQRLYENGYITYMRTDSTNLSETALTAARQQVRELYGDRYVPTEPRRYARKVKNAQEAHEAIRPSGEHFRTPGELARELSSDEFRLYELIWKRTIASQMIDAVGQSVSVRLSGTSSTNEVADFAASGRTITEPGFLRAYVEDIDESHEGDDQTDDSERRLPRLTKDDPLTAHDLLAEGHNTQPPPRYTEASLVKALEELGIGRPSTYASIMRTIQDRGYVWKKGAALVPSFIAFAVVQLLEQYFPRLVDYKFTANVEEDLDDIAAGERRRVDWLTRFYFGASDDANVREESVSRAGGLKHLVALNLGDIDARGVNSIPLFTDETGRTVVVRVGRYGPYLQRTSGPDDEGDRASLPDDLEPDTLTPERAEELLSAPQGGRELGTSPVTGEPVVAKAGRFGPYVQSGETTSSLFSSMSLETLTLDDALKLLSLPRTLGAHPGDGEPVTAQNGRYGPYVKHGTESRSLGSEDELFTVSLEAALALLAQPKQRGRRAAPAAPLREMNANDPVSGQPMVIKDGRFGPYVTDGETNASLRKGDEVAELTPERAAELLADRRARGPAKKTTRKKAAAKKAPAKAETAAKKTAAKKTTKKAPAKKKAPAKATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHR6</accession>
    <name>A0A010YHR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569717.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132127_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="13066" checksum="F7DE6757999E76DF" modified="2014-06-11" version="1">MSKKTIQRGAAVGAAAVCALVLWAGTGGHPVADGRTVGAGAVLATSVVAGLAGWALLAVLERFTRHAYAIWATVATLVYGFSLIPSAGAADGAANVGTLLGLHTIVYVVLMVAFGKSAQSVRAPQAVKPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YI27</accession>
    <name>A0A010YI27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848705.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_11"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="39808" checksum="5A17BFFBFA552899" modified="2014-06-11" version="1">MSSVQVLHVSHAVNTGLAHCVADYVEYQAKHGAQVTVACPGGRLATLAGARGADVVTWKAARGPGPGMLAEAGAFRRIFDEVRPDVVHLHCAKAGLIGRFVLRGRVPTVFSPHAWSFLAVEGAMRRAVLGWERFATRWTDVVICVSAAERDTGVAHGLHGRMEVLPNAVLPTAIEPIRARPRPAVREAFGLEPGVPVAVCTARLARQKGQDVLVDAWPAVRAAAPGARLVLVGDGPSRPALEAAVDAAGAEGVTFTGPVDREVALSWLHASDVVVCPSRWEGMSLVPLEAMALGRPVVATAVDGMAESVPPGTGWIVPPEDPEALAGAIVTVFGDPEGARSAADAGRRRAASAAGGDDSSARLLDLYGELLRGRRPPAEVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIC9</accession>
    <name>A0A010YIC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848776.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2750991_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="70" mass="7534" checksum="B69CE01EAFF00C4A" modified="2014-06-11" version="1">MTVTEQTDRTLDALLALREAIAAGSRTDRRAWVAAVSKMTGGGARTLAFYAALGRVLECVDVEYREAADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YII4</accession>
    <name>A0A010YII4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848854.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1111"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="358" mass="38403" checksum="952FC5BC35696E1C" modified="2014-06-11" version="1">MTSVLISGAGVAGPTLAYWLARSGFRPTVVEVAAGLRSSGNPVDVRGPALPVARAMGLMEELREHATLATGMRVVGTDIRLPMARGDEIELARTDLAAVLYRASRDDAEFVFDDTITALHEDRTGVDVSFARGTPRRFDYVIGADGLHSTVRRLAFGPEERFVHHAGLYIATVTLGGAPADPHDVMIYNRPRRLVALHPARGEAGAAFIFRGPALPASEYRDPERQKTIVTTMYRDDGWRVPELLDAVRNTTDLYFDAVSAVRLPRWSTPRVALVGDAASCVSLLGDGSSLAMAGAHTLASALANGGGFAAYEAEHRKLTTPKQRRIALAAGLLVPKTSLGIAVRNTIGRLGTLTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIX8</accession>
    <name>A0A010YIX8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">CryarDRAFT_1256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848989.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1237"/>
    <dbReference type="HOGENOM" id="CLU_049215_3_0_11"/>
    <dbReference type="OrthoDB" id="1942614at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="23235" checksum="95BCAF6CEFBBCB47" modified="2014-06-11" version="1">MRQALLLLADSRLPAGAHAHSGGIAPAVDAGLVEHDLALVADFLRGRLHTAGLLAAAIAARSCHLATAYSPAGAASGTGSTGAWAELDGEVDARTPAPEQRKVSRAQGRALLRVARRAFPHPGYDALGTHPHHPIALGVAVHAAGGTPEEAASVAVASAISGPASAAVRLLGLDPLALTAAHAALAPMADAVVADAARYADKPSDALPAPSAPLLDLLAQAHARSEVRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ45</accession>
    <name>A0A010YJ45_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytosine/adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849048.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1284"/>
    <dbReference type="HOGENOM" id="CLU_025810_5_1_11"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="16786" checksum="7C3AB1D5F4578EB5" modified="2014-06-11" version="1">MTITDVDTDHLRTAISVARNARVNGNHPFGATLVDASGLQVLAAENSVVTGRDATGHAETNLVRQATGRFAPSELAEFTLYTSTEPCAMCAGAIYWAGIGRVVYALGEDALGEMTGADPENPTLSLPCREVFARGQREITVDGPVDLPEARAVHAGFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJX2</accession>
    <name>A0A010YJX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849480.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1600"/>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_11"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458115" evidence="8">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="33104" checksum="2CC78B52709913E4" modified="2014-06-11" version="1">MARLGLGALIGVSVLVVSVAVAITIGPADLSVRDVFAVVTEHLGGPPSRLSTIRDAIVWDLRLPRTLLAAVCGAGLALCGAVLQALLRNPLADPYVLGISSGASTGAVLVLVLGVGAGSVGLGLGAFLGAVVAFALVLALARIAGGTTDRLILAGVAGTQLFAAVTSFVVISSADARQTRGVLFWLLGSLSGAGWGDVVLCAAVLAVGFAVCAGLALSLDAFAFGADAAAALGVPVVVVRAVLLGVTALLTAVLVSAAGAIGFVGLVLPHAARALVGPAHRRLLPATALVGAIFLVWVDTLGRTLLEPQEIPVGVVTALIGVPAFAVVLGRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKD4</accession>
    <name>A0A010YKD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849717.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_3_11"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="15498" checksum="C95E4738CDA9CA9D" modified="2014-06-11" version="1">MLIYVTAITASPGRIWNALIDPARTARYWGHHNVSTWTTGERWEHRRVTDGGAETVGEVLEIDPPRRLTHSWARAGEEHDPARVSRVTFDLEPVGPRVRLTLTHEGLPTDQVAGVGAGWPFVLASLKAYLETGYPHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKM4</accession>
    <name>A0A010YKM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar phosphatase of HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849806.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1807"/>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_11"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27675" checksum="3234F7C6DE0F384C" modified="2014-06-11" version="1">MTSRKSIDCWLMDMDGVLVHEGVPVPGAPEFLGKLVEKGRPHLVLTNNSIYTPRDLSARLQRAGINVPAESIWTSALATAKFLEDQRPGGTAHVVGEAGLTTALHEIGYVLTDADPDYVVLGETRNYSFEAITTAIRLIDRGARFIATNPDPTGPSHEGALPATGAVAALISKATGVEPYFVGKPNPLMMRSALNAVDGHSESTVMIGDRMDTDVIAGMEAGLETVLVLTGVTRAEDVNRFPFRPSRILNSVADLVDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKW0</accession>
    <name>A0A010YKW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_1965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849985.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1929"/>
    <dbReference type="HOGENOM" id="CLU_031114_2_0_11"/>
    <dbReference type="OrthoDB" id="262439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="538" mass="59286" checksum="DCE75C92128C5DC1" modified="2014-06-11" version="1">MPLLPKIKPAAVGTWADDRLEASTPMRRVFNKVFPDHWSFMLGEIALYSFIVLLLSGTFLTLFFTPSPTEVVYDGVYTRLQGVEMSKAYDSALNISFEVRGGLVMRQIHHWSALMFVAAMLVHMFRTFFTGAFRRPRELNWVIGVTLFVLGMFEGFLGYSLPDDALSGTGLRIASAIIYSIPVVGTWVSFALFGGEFPGEFILERFYIIHVLLLPAAILGLIAAHMGLLVKQKHTQFPGPGRTEQNVVGHRMFPGFAAKAGGFFMLVFGVIAGLGGLVQINPIWLFGPYEAAVVSAGSQPDFYMMWLDGAVRLMPAWEFRSFGYTIPAMFWPSVVLAGVMFTLAGAYPWLEQKYGKDRSHHNLLQRPRDAPARTGLGMMAISFFIVLLLSGGNDIIADKFDISLNATTWAGRIGLFIVPPLAYFFTYRICLGLQQHDREVLAHGVESGMIRRLPSGQFIEVHQPLGEADEHGHTHLEYVGAAVPKKMNKLGAGGRAVRGFFIPVERPQEVEKTAVGTGTDGKKPSELSGASASDSGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLF2</accession>
    <name>A0A010YLF2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2121"/>
    <dbReference type="HOGENOM" id="CLU_013446_10_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="570" mass="61864" checksum="E83ADE3D02A92272" modified="2014-06-11" version="1">MREKNSYAKDVMNSTFRPLIAALKKRGADPVALAKAAAEAERTGRSIRGILINNNVVTEAELTAAAADVYGMNSVDLVGYPIDPVAMAKIPIALVVRHRVLGLALDGNEITVAITDPSDIVALDDVRAATGMVVRPVMVARSELRKLIAKLQREENDLADLAENLRPEAPTAASVSSLTSSDQDAPIVRYVNSMIGQAIQNRASDLHLEPGENEMRIRFRIDGVLHEIDTVPHNVQAALVSRLKIMSGVDITEKRVPQNGRITVEINDRAVDLRTATLPTVWGEKVVLRVLDTGSGMQIDLSSVGFTDSNLKRYSTAFTKPHGMVLVTGPTGSGKSTTLYGTLAEISKPTVNIITVEDPVEYRLPGVNQVQVNLKAGLTFAAVLPAILRSDPDVVLIGEIRDRVTAQLAVEAALTGHLVLSTLHTNDAPSAVTRLIEMGIEPFLVGSSVDCVVAQRLARRLCDWCKEEYEPTETELKGTDWPVEDLGQPKSLWKPVGCRNCSGTGFRSRVAIHEVLPISDEIERMAVNRASAREIREVAWAEGMRDLRIDGLRKAATGQTSVKEVLRVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLX1</accession>
    <name>A0A010YLX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850436.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2283"/>
    <dbReference type="HOGENOM" id="CLU_024435_3_1_11"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458862" evidence="2">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="451" mass="47446" checksum="26B8EDB5E1A27039" modified="2014-06-11" version="1">MKSIARAVIAGGLALTLAACTSSDADPEESPPSAAPATPAGPELETTTVKALPGTEEAPFDQPRELQAPPGWTVSVWARVPSARLLAWTPDNRVLVSRPKFGDVIELVPGEGDAAPTQRPLIEGLNQPHGLAFHGSTLYVAESDQIDAFTYGNGKLSGKKVVVEDLPDAKSSDLKGAYAHALKSVAVSKDGRQLYISVGSTGNISAEDRDSDPERATILTAPAAGGDPTTFARGVRNGTGLAIDPDGGVWTAVNHRDNLQYPHKTDIDGDGSPDNGDVIQEYVNDHPLEPLAKLTQGRDLGWPYCNPDPDLKPGEKDSPLGYTKRPLVNDDELNPDGSKLDCASLAPAEQGMGAHSAPLGLSFADVGGDYGPGALVGVHGSWNRKPPRPPEVSFFPWRNGTLDAQQTLLTGFQLEDGSRWGRPVMAIAGSDKAIYVSDDAAGAVYRVTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLX7</accession>
    <name>A0A010YLX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570037.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2288"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="187"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="364" mass="39291" checksum="AA40671C645550D9" modified="2014-06-11" version="1">MSTRTLSFTEPTQGRLRRLNLVTSFPPLVVAAAVLIVLDTHAWWHPIPLAVGVGTAIVAFERWTANDLRRFAVPLLAVAGVVWVLGVLVIGSPNAYWGAATVGSLAVPQLPRRRLAAFAGLLGFVAGVGALRVLVDGGDALVSFVVVPAALTTVSGVLCLAGERFYDVVRELEASRAREAELAVIRERVRFAGDLHDIQGHTLHVVKLKATLARKLVRDAPERAEEELREIHGLVSDTIQQTKDLAYAQRRLNLAAEVENAKNLFEAAGIRVRVTREAEADARVSELLGQVLRETTTNILRHAQATRVRIVLAAHAITIVNDGAAEGPPELRGLSALRRRVAEDGGSLTARAHAGEFTTEASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNA8</accession>
    <name>A0A010YNA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851083.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2751"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_11"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="225"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="283"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="541" mass="55548" checksum="350E31BBB77F5120" modified="2014-06-11" version="1">MAQPHSVEEPTGRRRLWGDLKVGAKITLAVLAALAVSCAATLVTLLQTAEVRSVGKAIYTNNVGPLITVGELRDAFRLMRADQNSLALLDAGSTASTQKAQQISDDGETITVLAAKYRSTAADPTLVDEFVTAFTTYDDIATAQMIPAAVAGDRARYVRVKEGPAKAPYLAAEDALKKITAAENVQAKDRADELDKRYATALTISVAGLLTAIAIGLVLALWVARGISRPLQGVGAALDRMADGDLTTTVPDPGTRDEVGTMARGVKRTLDSMRASVAEVLQQAGRVTAASQELSAVATRIETGATTTASGSQTASLAANEVAASVSTVAAASEEMSAAIAEISRSAASAVEVAQQALNTAQQTNDSVAALGAASVEVGDVVKVINSIAEQTNLLALNATIEAARAGEAGKGFAVVATEVKDLAQETAKATEEITRKIAAMQASSDEAATALGQINAIIEQINEHQTTVASAVEEQTATTHEINRSIGQAATGVDHIAQTVSDVSTTAEESNASAAQAAGAARELALTASALNDSVAGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP63</accession>
    <name>A0A010YP63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851491.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3061"/>
    <dbReference type="HOGENOM" id="CLU_064271_0_0_11"/>
    <dbReference type="OrthoDB" id="1219471at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="160"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="363" mass="39017" checksum="24257FABAC6223C8" modified="2014-06-11" version="1">MTGSPVGAGRAEVDAALVLLARLGVRPEDLVGAGGGRAVVPTFAEYVPVVAAAVGAGTRRVYGSYWNRVVEQWGARRLDEPSPSEIARLAETLRARRVVRANARGGQSTSEHLIAALRCVYRHAVADGLIGEGDNPARKVPKPRRAPSTRGAVGAERLAEINQVAATTGDDPALDTLLLRLHTETACRRGGALALRPCDLDATQCLVLLREKGEISRWQPVSPTLMRHLLRHAEERGAPRTGQLLRYRSGRPITTRRYDYLWKRIGQHLPWVAAQGVSTHWLRHTTLTWVERTYGYAVAHAYAGHTDRRGGGETGATITYVRASHEEVAAALVGLVAESHPLAPLPGVAPGPSPGETNAGNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPN7</accession>
    <name>A0A010YPN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PLP-dependent enzyme possibly involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851746.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3250"/>
    <dbReference type="HOGENOM" id="CLU_033332_2_4_11"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="351" mass="38820" checksum="831612BB9F6FA802" modified="2014-06-11" version="1">MSYAYPVSKPWLGDREQQLVGEAIASGWISSQGPEIKRFEAAFAEYNGVAHGVACSSGTAALTVALAALGVGPGDEVIVPEFTMIASAWAVNYVGATPVFVDCGDDLNLDVTKIEARITSRTAVIMPVHVYGRRCDMDAIMELAYDYNLRVVEDSAESHGVRPVGDVACFSLFANKIITAGEGGICITNEPRLAEQMAHLRAMAFTKDHSFLHKKIAYNFRMTNLQAALASAQLERIDEILSRRRAIEKYYDAALAGIPGVTLMPPRDVLWMYDVRVERRAQLQAHLAENGVETRLFFKPMSRQPMYFDAGWPELKAAAFSEDGLYLPTYPELTEADQEIIVGHIRSFYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQP8</accession>
    <name>A0A010YQP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725920.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3687"/>
    <dbReference type="HOGENOM" id="CLU_119509_1_0_11"/>
    <dbReference type="OrthoDB" id="1412344at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="111" mass="11661" checksum="05EAEE8F9E8F8FFD" modified="2014-06-11" version="1">MITVCRDCCCGSTTKHPSVDHHGQLARLRDALGDTIRVRVSACLDRCAQSNVLVVNPSPAGRRAGGRPAWLGLVLDPDAIDDVIAWVRAGGPGIAEPPATLDLYAIDPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQS2</accession>
    <name>A0A010YQS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_3746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101331_1_0_11"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="18283" checksum="DB6AFFB8D29C51EF" modified="2014-06-11" version="1">MRVVVATVALVVIGVLSVSLFSKLRSRGDFRDFVGGLGALRVVPGRWAPPLAALAVVAEAAVLGALVWPGGLVAGLAGATLLFGGFTAALSVAVGRRATTGCHCFGVSSTPVARRHVARSGVLAAASLVALGGAVTTSTERVTGLPAAQLIVAFAAAGFLVASLVWLDELLWLFRRPASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR49</accession>
    <name>A0A010YR49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852606.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3837"/>
    <dbReference type="HOGENOM" id="CLU_035614_3_0_11"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40370" checksum="8463411CD9C7336A" modified="2014-06-11" version="1">MTEVHGHVDNRFSAVSDALAKNLADGVEVGASLVVDIGGETVVDIWGGHRDAARTRPWTEDTIVTVWSSTKTVTSLAALMLVDRGLLDPYERVARYWPEFAANGKDAVEVRHLLSHTSGVSAWEQPFAAEDSFDLAASTAKLAAQPAWWEPGTASGYHASNFGHLVGELVRRVSGRSLTDFVAEEIAGPAGADFQLGARPADHGRIATMLSPEAAPPAELPPPDPGSVFTKTLMGSFQDPAIANTPEWLAAENGACNGHGNARSVARIVSALALGGVTGGVRLLHPETIELIFDEQAHGPDLFLGIPLRWGIGYALPEPEGTPFVPAGRVCFWGGWGGSLIIVDVERRMTISYMMNQMQPGIIGSPVSAAYCDVITACAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX78</accession>
    <name>A0A010YX78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848531.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.791"/>
    <dbReference type="HOGENOM" id="CLU_031285_8_0_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457725" evidence="1">
        <location>
            <begin position="27"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="47965" checksum="83CA77A02008B1EE" modified="2014-06-11" version="1">MRATRAVGAALAAGLLLAGAACTSSDDGKSADGKVRITVNCEPPKSAAIDRRSFEEDIAIFEKQNPDIDVVAHDAFPCMDPKTFDAKLAGGQMETVFYVYFTDVANVIKRKQAADVSEYVDAVKGYGDIQASVTDIFTSDGKTYGLPRTNYSMGLIYNKALFTKAGLDASKPPTTWEEVRAAAKKIAGLGNGTVGYADYSASNQGGWHFTAEMYSQGGTMVSEDGKSATVNTPQGKVVLQTLKDMRWTDDSMGSKQLLQITDVQQMMGSGKLGMYLSAPDNIPEVVKKYQGSYDDLAIAPMPGAKGTLLGGDGYMFNRKATPEQIRAGVKWVEFQNLTPGTGANNWERAAKNKAPVGLPQPNLWTGATADADNKLKAQFANVPVENYQLFQTTEVPGKLEPPQAQQIYSVMDGVMSSVLTNRNANIDRLLSDASDKIDRLLANQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYP8</accession>
    <name>A0A010YYP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569856.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_11"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="77"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="33450" checksum="6FC4AE9B9AFBC302" modified="2014-06-11" version="1">MNLHPQAVADLASETIPDGPVPEPTLADIAAARAAENDNAPMLGGPPAPVAIVVDLEADGVPIRLYNPRGGRGTPVMFFLHGGGWVGDSLVTHDAACRRLANRSHCAVVAIDYRLAPEYPWPAQVEDAVHALAWVRDHADELGLDISRTAVVGDSAGATLAAILARRARDAHVAFDFQALIYPPVEPFAEPPLGPDPRDGTEHGLSVGEMNWAWKTWLGGADPDNEDVAPARIKDMAGLPPTLIVTAEFDVLRDGAEAFGEALAGAGVPVVTTRYLGVPHGFFRRLAVYDASRAAVDQVAAAVKDVLDPIAFPVQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ37</accession>
    <name>A0A010YZ37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849400.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1535"/>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_11"/>
    <dbReference type="OrthoDB" id="1169054at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="37185" checksum="6F120D14D38551EC" modified="2014-06-11" version="1">MPRPVTLFTGQWADLPFEEVCKLASGWGYDGLEIACWGDHFDVAQAVSSPSYVASRREILDRYGLKVWAISNHLTGQAVCDNPIDERHQGILSPAVWGDGDAEGVRQRAASALKDTARAARLLGVDTVVGFTGSSIWHLVAMFPPVPPSMITRGYEDFAARWNPILDVFDSEGVRFAHEVHPSEIAYDYWSTVAALDAVEHREAFGLNFDPSHFVWQDLDPVGFLWDFKDRIYHVDCKESVKQFNGRNGRLGSHLPWGDPRRGWDFVSTGHGDVPWEPVFRMLNSIGYSGPISVEWEDAGMDRLVGAPDALAFVRKLTSIEPPEASFDAAFSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZT3</accession>
    <name>A0A010YZT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849743.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192630_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="11900" checksum="D3DEE2CBB295CBBE" modified="2014-06-11" version="1">MTTPNPFDDTDRVLDRITDRFDERYDGEVPREKIEQEVHETYTELAADAKVDTMLPALTEHEVGDRLAEEVGRPAPLVDEPGEGGPQLRAGASNPETDTDLGRPVGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z071</accession>
    <name>A0A010Z071_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CryarDRAFT_1943</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849955.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094161_0_1_11"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EXG80848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="188" mass="19300" checksum="A6BD00742918483C" modified="2014-06-11" version="1">MHTLVLGGIRSGKSAWAERLAARGSGPVSYLATAPDRPGDADWAARVRAHRERRQGSWVTVEVGGGPAALPSALGTLPPGAAALVDDVGSWLVGAFDAASAWEADDPWDAIAPDVSALLSAVVACPADLVLVSPEVGWTIVPATRSGRVFVDAQGTLNQRLAAICEHAVLIVAGRAVRLPDGADSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0M4</accession>
    <name>A0A010Z0M4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2067"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_23_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="293"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="55656" checksum="65460D5B02C9087A" modified="2014-06-11" version="1">MRSAATRMRFGFAIVIVFLVLAAVVEFASGALHGGIFSLGGAILVGLIGVRLGREIAQPLDALGDVLHRAAAGDLTARAPLGGPKEAATVYAAANTVIAECEQATSVEETRRLVRRLADPNGETPSAKGPEAALADVVPRVGAALAVDRVFVRVTAGKTYVAQWQRDGLQPVSDELPLLPPDPRSSEPVGTPDAHTNLRGDPILYGDTPRARAARTLTEDADARALVTTRISVAGKPCGALMVMDSGGPRSWTPGELDLLTSVAADLSRMVENAQLRADQRRLESEKQLFIATASHELRTPLASVLGYLELLAVGDFGGLTEDQLNAIRVVERNTTRLHELVLDLLTISGIGPAGDLTERPPVDLSDVAMKVITETEALATEAQLELRYQEKDPATVLGESRQIERALTALVHNAIVFTPAGGSITITLDRDTGDGRPIGTARLAVADTGIGIPEAERGRALEPFYRGTNALERGIAGSGLGLSIVAMVAQQHAGTVTLTARPGGGTEATIHLPLAQYTAAAVSGAIIGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1T4</accession>
    <name>A0A010Z1T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725704.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459005_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="185" mass="19745" checksum="88D8E6EF3B23A2D0" modified="2014-06-11" version="1">MTETPDPGSPTGEAYDWFRRGEELLRQGNAAAAAQLLQRALAADPGSRSARESLARALFDSEQYAEARELFAQIVADHPSDDYAQFGLGLAALRTGDPKVAVEHLSLAVAMKPHDHHYATALRNARAQNAVDPVGGPATAGAPVEEQRPTRGSTVNVPVEIEELLRGIERSDGAPDDDAPNGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z224</accession>
    <name>A0A010Z224_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850815.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2556"/>
    <dbReference type="HOGENOM" id="CLU_870895_0_0_11"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="33177" checksum="D1D116D8AE7723C8" modified="2014-06-11" version="1">MTTYATPDVVAARGRVGARLVGRERELDLVLAAVAAGRDIVLEGPPGTSKTTMLTAITAEWGIPLLFVEGNADLTPAKLVGHHNPARVLTEDYSEDNFVPGPLSEAMRQGGFLYIEEFNRAPDDTLNTLLTAMADRRLSIPRAGTIEALPTFRIIASMNPYDNVGTTRLSSSVHDRLCRLAVDYQDASAEEGIVALRTGLAAGADLVGDAVTVTRATREHPDVRQGSSVRGAIDTALVAVQLGALRGLTVTGPVTRASTDPYAQLFLDAMLVALSGRIHLDEAADTTPERVLREIWEDRFILQPSAARPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2A1</accession>
    <name>A0A010Z2A1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570105.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2681500_0_0_11"/>
    <dbReference type="OrthoDB" id="2040098at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="74" mass="8218" checksum="C02ADFC1842B1BAE" modified="2014-06-11" version="1">MRWNLRWVAANADIWRPADLLQACRAAGYSPSLSKVASWWNGTPSTVRLDELDMICTALNCKIADLLEAEPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3K8</accession>
    <name>A0A010Z3K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851496.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988913_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="14180" checksum="179D8FF89E9AB455" modified="2014-06-11" version="1">MTELVPVDQTPTQQLADVRSAYDTLRAQIRAYVVDQHRRGEICRAGLNAFLVHFDLGLYRPHHTVTFTVTGTFELTREDDHGLWATENDVRHRLLVDTGHIRGVLDGTVDFDVHVTATLSDQKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3M5</accession>
    <name>A0A010Z3M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="307" mass="33205" checksum="EAB3AF105A563A3C" modified="2014-06-11" version="1">MVASSASRQSSGPEDSDDIRPSGQQPPSQTSDPGVIRVFVIDDDEILLHGIDAWLCQGNAAFGGPTDGLEIRVVATAKSVTELLSTHWQGQNPAPPPNPNSGIPLAGYNDGHHRSHNISRPAVPPVRRGPYAEEPPRPRLSPVALMDLRLRDGRRVAENVRALIEAGYAVVTCSTIDDAGLVHEVGRAGALSYVRKAREAGDMRQALAAAARGERYVSQSHAALIQRARSYGVPELSGQEREALRLYASGLTMSSVARRLNVKQGTAKSYLDRVRDKYEQAGRAARTRLELRDRAIEDGVLNSPTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5L0</accession>
    <name>A0A010Z5L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852560.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3802"/>
    <dbReference type="HOGENOM" id="CLU_600827_0_0_11"/>
    <dbReference type="OrthoDB" id="534010at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458950" evidence="1">
        <location>
            <begin position="27"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="451" mass="48091" checksum="DBB738A9298EF149" modified="2014-06-11" version="1">MVRFRAARRSRLVAIAGAAALTLALAACNSGGGSTAGEYGFPQVKQDDKATITVWVDADRTKAADAFTKANPGTPIKVVTYDGSANGSNSFRTKVQLFDRAQSGWPDVVFSSQNNDAAWASQKSNGKQAFAAVLNDGLVAKDTLDQFTSGSLNPCTVDGKVYCLRNDLAQAVLWYNKTLLDQFGYQVPKTWEEYQALGEKVGREHPGYIVGTVGDAWTPEVFFWASKCRANGITGPKAVTVDTGSAECKRAATMLDTLITNGTTPNVSVFTPEFVKKYSGKVLLMPGPAWYAGAIFNNPESLNVPKGQLGVAPPPAWGSDKAVTGNVGGGTWFVSSHSKNLKAAESFVRFVTTADDYQVAVAPGYPAYAPAAEKWVKKQETSGYYATDLTAVVEAGTSIWDGWGSGIFSQEAVWAKTITPAIAGGKSLVSLLPEWEQAIKNQAQVNGYTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z657</accession>
    <name>A0A010Z657_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852708.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3945"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="25853" checksum="1BB758EDF6DF539D" modified="2014-06-11" version="1">MSRFAGRVALVSGGAGGAGASAVRLLAEQGARVIVVDRQEELGRALADEVGGFFARADVGRPDEVRAAVAAGTAALGPPTLLFNHAGTLVVKPFLETTMDDYDFLMDVNVRSMFVMTQAVLPGMLGAGRGAIVCTSSISAVAATPAEVLYDVTKGAVHQFARAVAVEFRDRGIRCNAVCPGFIDTPHGRNEVALLTKYGVDVSDEAIAAAQGRMCTPEEVASAALFLLSDEASFVNGAQLFVDNAFTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK89</accession>
    <name>A0A010ZK89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2971814_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="58" mass="6372" checksum="E591C4279F675C3B" modified="2014-06-11" version="1">MAPSNLTVYYSDGSDASFDDVTYRVADDYLYVEPSSGDAPPPIELFSVYSWVARTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKZ2</accession>
    <name>A0A010ZKZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847852.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.311"/>
    <dbReference type="HOGENOM" id="CLU_131959_0_0_11"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="111" mass="12263" checksum="E04A39886EDF0205" modified="2014-06-11" version="1">MTPVEVVRASMAAYRAQDLDAASALLASDYVFFSPQDAGIDKATFLERCFPTADRFAEQEVVHVVDLGGGEVFLLYEYVVESGRYRNAEVSRVRDGQLVETQVYFGGRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLS9</accession>
    <name>A0A010ZLS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848372.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.641"/>
    <dbReference type="HOGENOM" id="CLU_089258_0_1_11"/>
    <dbReference type="OrthoDB" id="1629615at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19849" checksum="D77772E6B7C61117" modified="2014-06-11" version="1">MSTPQVLLALLATGPRHGYDLKRAYDVRFPKARPLAFGQVYSTLERLTRDGLATEAGVERVDGPDRTVFAITDAGRESLREWLDVVEPPTPHVTNALFTKVVAALLVDESPDGLAVTYLRAQRRAHLARMRDFTQVKTADGVSVGEVLAADYALAHLDADLRWIDLTLSRISALRQEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM12</accession>
    <name>A0A010ZM12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848466.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980377_0_0_11"/>
    <dbReference type="OrthoDB" id="1918411at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="14541" checksum="68BE3F689D36DC66" modified="2014-06-11" version="1">MGQLSQTRAVVERYLAALNAGDADEVAACVTEDFHNEHTSATARSLTGRTAYRERLGGFLAEFENLHYDVEELLVDDDRAAVGYVMTFRIGGKPVRVRGMFWFRVEEGLIAHRRDYWDGTTVKQQLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM17</accession>
    <name>A0A010ZM17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848475.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.735"/>
    <dbReference type="HOGENOM" id="CLU_107520_1_0_11"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="14494" checksum="D1C90EDABE4AD026" modified="2014-06-11" version="1">MPTFRISEAAALLGVSDDTVRRWAEAGKLPTVREPGSRIAIDGRELAAFAADIAADRPAGFDSPIVAESARNRFAGIVTRVVRDGVMAQVEIQAGPHRVVSLMSRESADELGLEPGVLAVAAVKSTNVVVEVPRHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN03</accession>
    <name>A0A010ZN03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1110"/>
    <dbReference type="HOGENOM" id="CLU_1657911_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="16937" checksum="B994FA856AC6693D" modified="2014-06-11" version="1">MEEVPLQHDSSGLALPFKVPRTPLTIRTTGLSADELSAVTVALVLLTQDPPGPDELTGAIAGLLLIVRRFRRLKAANGEVSVVDAIVRTRPRSTVDAVTLFLYGKACRNPNAACRFLAEDGTTCGITRDQAQGTVDFLISEAVLKPTGGVPPIEYAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN30</accession>
    <name>A0A010ZN30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848875.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1135"/>
    <dbReference type="HOGENOM" id="CLU_044949_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="337"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="406" mass="44652" checksum="C47BB1C59B2FA74A" modified="2014-06-11" version="1">MSQLAVRPGAFEPWAGLPAELAEVIKPELGTLAEEIVEAVREGIPEFGRSMGESYEYVIRVGVERALTQFADKVGDPNLTVDDWDAVHRKLGYGEFQQGRSLDALQAAYRLGARVAWRRLADAGLRLSIPAPLLFQLGEAVIAYVDQLAALSVEGYAEAQAHAAGARERRRRQLMQTLLADPPPSEAAIADLARTARWTVPEQLVAIALEPRADDRELTLPDLGPAVLIDLEGSEPCLLVPEAQLDRTEAALRSVLHSSRAAIGLPVAVADARRSLRWARRALAFLRRGSLSRQQVVRSADHLSTLLLLADEALVEVFAERRLAPLRQLTAKQQVRLSETLLAWLETRGGAPEVASRLQVHPQTVRYRLRQLEALFSDQLHDPDSRFELECALRALAVVRAPATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNC4</accession>
    <name>A0A010ZNC4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1231"/>
    <dbReference type="HOGENOM" id="CLU_001265_60_5_11"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="41147" checksum="A32AEF60606C403E" modified="2014-06-11" version="1">MKHDRVSTRLLLGAGINGVGGGLWFTIWALYLTRVVGLSPGELGVSLAVAGVVGIGLSLPGGAIADRVGARRVSLTINLVRAVACLAFLRVDGMLALTLVAAVFNGAQVVGSGVSNALITGLFTGDGRVRMLARSRAAVHAGNTVGAGLGAVVLAVDRPWAYVAAIVGNAATFVVNAALLSGVPETTRGRQLSRWAGLRGTAIRDRRYLAAMVPITALTACWAVQSVGIPLWVVSSTEAPAAVAATTVIVSSLLIAALQSAVSARITTIRRGARAATLSGVVLGASCLVFVPAAWVPAGWAVVIVLVGGLLHVAGELLFMSGQWGVSVGLMREECRGEYQGLNATMTGAVQEFSPAAVAALVGGLGAEGWLVLTGFFVFCAAPIVPLASRAERLRLGQTRSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNV0</accession>
    <name>A0A010ZNV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SnoaL-like polyketide cyclase,polyketide cyclase/dehydrase and lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569862.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1406"/>
    <dbReference type="HOGENOM" id="CLU_862543_0_0_11"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459136" evidence="1">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35039" checksum="A8D88AB545DCCEF4" modified="2014-06-11" version="1">MEITKYLAAAATGVAIVAALPTAASAHRSYERCGGTTVDRSAPVIARASVFVRASEDLTWRMHTAIDEWETWIPEIVPARQSTPGPLRPGSVFDWSPQNMTVTSTVTKVEPRRCTAWAAPVNGIDGVHLFTFEKVRGGVVVTTEESWAGKPVQADVPGFQKLLQTGLDDWVGRFKEVAERGGPARNEVRRTPRIVGDWLRYWNAGDGKRLGSLFTPDGRYTDHSAGVTFTGPAGVAQWVATTVGGVDDVHGDLRQVHRYGDRIVLGWTFSGHVKGAPSAFRLPAVTVLQLRGNRVVSNDDYYSHADLLARSGLPADWKPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP99</accession>
    <name>A0A010ZP99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849430.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146077_0_0_11"/>
    <dbReference type="OrthoDB" id="1940151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="100" mass="11332" checksum="D19B825915DCB793" modified="2014-06-11" version="1">MTTPVAHKPHTEHDHQHGDTCGHTAFAHEDHTDYAHDGHVHRVHEDHVDECEPVAHRVHAEHAHEHGTDCGHPAVSHGDHTDYVHDGHRHAPHDGHWDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPZ2</accession>
    <name>A0A010ZPZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569949.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179200_1_0_11"/>
    <dbReference type="OrthoDB" id="2009249at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046156">
        <property type="entry name" value="DUF6158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19655">
        <property type="entry name" value="DUF6158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="84" mass="9321" checksum="4054B13AA845A663" modified="2014-06-11" version="1">MTISGEARSAGATGVGPGQLADEDLLRELLRLHEMRHETLRHGSDDALDAHTARTGELEAEYLRRFPQREVDPGRLRSGARSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ70</accession>
    <name>A0A010ZQ70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-ribbon protein, possibly nucleic acid-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849884.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1862"/>
    <dbReference type="HOGENOM" id="CLU_073076_0_0_11"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26976" checksum="66DBEE5510D7A5A8" modified="2014-06-11" version="1">MKAPAADQLRLLDLQAVDLSIDQLAHKKRTLPEHAEIEKTAASLAELRDELAGAESVVEGLDRKIRGLENEVEQVRARAERDTQRMQSGAVGAKELERLQHEVDSLGARQSALEDDELVLMEERENADSVRSGVQDRFDAANEGLAALEVRRDAIENEIDADVAARTAEREPIAASIPEDLRALYEKLRASSGGIGAAALRARRCGGCRIELYGTALQEARAADEDEVLRCEECRRILVRTGESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQA9</accession>
    <name>A0A010ZQA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847987.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.406"/>
    <dbReference type="HOGENOM" id="CLU_055635_0_0_11"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="155"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="309" mass="31329" checksum="DA8F78F6E8D2F050" modified="2014-06-11" version="1">MDHAHGSPLDPPNPADRPGRLAVGLVGVGRAGSVLAAALARAGHRTVALSAVSSASRRRAAERLPGAPIVPPDAVVAAADLALLAVPDDALEPLVTGLAEVGAFRPGQLVVHISGAHGLDVLQPATRAGALPLALHPIMTFTGRDEDESRLAGVHWGVTTVPELRPVGEALVVEMGGEPLWVENSQRPLYHAALVVAANHLVTLINDAVDLLRAAGVERPGAALAPLAGAALDNALRSGDAALTGPVSRGDAGTVANHLDALRGRQPSAVAGYLAMARRTADRAIAAGRLDPASAENLLDVLGDHSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQE4</accession>
    <name>A0A010ZQE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.451"/>
    <dbReference type="HOGENOM" id="CLU_031758_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="43698" checksum="ADE7CBFEBCA10338" modified="2014-06-11" version="1">MELLVTYARLRDGRVVDLAVEGARLRVLPRGTTPTVPPRVVRADGRLVTESAVDNHLHLDKVHTLDRVGDSALSAYTDDAMAGAMTSIELASAVKAGYRSADALPHVRRALTDAVRHGTLHVQAFVDVDTAAGLEGFRAVVEARREFAGVLDVRIVAFPQDGIVRDPGAAELCEEAIRLGADVVGGIPWIEHTDVDARAHVEWACALAARTGKRVAMLTDDAGDPTLRTTEMLAAAMLEHGLVGRGVACHARALALYPQPSLLRLAGLAKKAGLGFVSDPQTGPLHLPVALFRDLEVPVALGQDDIEDAYYPFGRANLWEVAFLAAHLLDFRTAAAQQALLDLVTTDAARVFGLAHHHLADGAPANFVVHDAERVVDVLRRHAAPRWVVSRGRVVAETTIVTDIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQN6</accession>
    <name>A0A010ZQN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FlgN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850136.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2049"/>
    <dbReference type="HOGENOM" id="CLU_130806_0_0_11"/>
    <dbReference type="OrthoDB" id="1624759at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17506" checksum="D3C3225B2CFEF5E7" modified="2014-06-11" version="1">MAFADLSNILWRGREMLELLLFKLEEEQLVLASARTRWLAHATREVELVLEQIRQVEVLRAAEVEVVAALLGLPPNPSLSALSEAAPDPWGKLFAEHRKAFLTLTAEITALADANRDLLTSGHRAVRETLLTVGGAVETYGPRGGTVTTGARPRLVDEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQS5</accession>
    <name>A0A010ZQS5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848304.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_1_11"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="75" mass="8076" checksum="7B1312C252C6B3A2" modified="2014-06-11" version="1">MSDVDLSEAVWLRSSRSAEDQGPTVEVAFVGDQIAVRDSTDPAAVLLFTQAEWDAFLAGVNDGEFDLDDEGELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRZ2</accession>
    <name>A0A010ZRZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850738.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2499"/>
    <dbReference type="HOGENOM" id="CLU_041026_0_0_11"/>
    <dbReference type="OrthoDB" id="1271858at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="365" mass="39129" checksum="5A70666ABA1AD4D2" modified="2014-06-11" version="1">MPKLPPPDPRLDQLRGGVPPKRHNARTIAALTTNPGCVRRAVLDTAGIDKDALARHLEFPAPFGQSSFAITRGNAFEAQLKADGCAELLTLLRETLDLDLTEVAYADLESVGDNVSENARNTYSEQRLAHGDENTLFDHPLLRLVVAGQSVYLEPDLVAFQHHGVYHVVEIKSFAVIDGQADPAKVAAAAIQSAVYVHALRQLLGRPEAVADEVVLVCPKDFSNRPVATKVDVRKQLLVLDHQLTRMDDVDTLLSALPAGLTLGLAPDPEGTPTRPVAELTASLGELSARYSPDCLGHCELGFFCRDEATGCTDALGTAVREQLGGVDTIAEALQLAQGTWAGDEHQAEVAAVLRTTARVFSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS07</accession>
    <name>A0A010ZS07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation and spore germination family protein,'beta-propeller protein, lipoprotein LpqB like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464397_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459225" evidence="1">
        <location>
            <begin position="29"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Gmad1" evidence="2">
        <location>
            <begin position="356"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="587" mass="62133" checksum="2F52B8B85392B55D" modified="2014-06-11" version="1">MARKRLVATALVAIALSSCARVPDSGPAVPVAIPGASQSTDSTITSVNAQLPGPGPDSDESVQAYVNALAVTRNPGPLGDRYLATPAIRNAFSQNPSMVVVRGGIEKSVQEATRDEATATFSANLIGTVDSDGVFEEAENPKWQVQVRLTRIRGIWLFAEPPPLIVPENKFTESFSQETVYFSARPSTITGPTPRLVVPERRWLNEDIGDQITQIVDFVLAGPSEALSQVTENPLPNIKRTSRVAVQDGDLVIELEPQAEAMSRDALDAFVAEVGWSLNGKFSGAVRLNVGGRALDVQGFDARQDLGSWRRYNPAIVQRNLPTFQVQKGTVKVLNDPSARDVHRPYRLGTPVLSRSVRVAAISVDLVRFAVVRDEASGQRLWVGDASGTLQPTLRAPQIGRPSWGGNRATVLVPVGGRLFEVGVGNAGQPSEVQVVGPGGRRLRDITSVRLSIDGVRALIVAGTGVYVGTLTGATGRAPVLSVRPMTVPGVPLDVSWLGPLDAAVAVALPDQQNRVALVRAPVDGSLPEVHGAIPNTGGPVRVSADPTENPESLVLLEVSGKRYVLPARGGTSDIAPAVATAPFYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS12</accession>
    <name>A0A010ZS12_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848761.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1038"/>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="437" mass="47069" checksum="5DC3A08040BDDD43" modified="2014-06-11" version="1">MDSVGAQLALVLLLVLLNAAFAGSEIALISLRESQLQRLSRTGAGGRVLARLARDSNRFMATIQVGITLAGFLASATAAVSLAQPLVEPLSFLGNAARPVSIVVVTILLTFVTLVFGELAPKRIAMQRAEGWALAVARPLDLLSTLSRPAIWLLGITTDAVVRLLGGDPDRQREEVTREEVTEMVSSHKGFTPLQQTMIVGALEVGDRVLREVLVPRREAFVLSAEFDIPRARAALVASGHSRAPVAPRGSLDEAIGVVHLRQLIDDEGTLADRVLSVPALPGSMRVPDALRELSMARTQMALVVDEHGDIDGLVTVEDLVEEVVGEIYDETDKDIQAVKISEDGSMVLPGSFPVHDLVDIAIELPHRPEGDYTTVAGLILAVLGRIPRSPGDVVTVDRWSFEVRAVRRRAITEVMVRPEPDASVEPHELEEPATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS27</accession>
    <name>A0A010ZS27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase II (Cobalamin-independent)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850804.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2547"/>
    <dbReference type="HOGENOM" id="CLU_058877_0_0_11"/>
    <dbReference type="OrthoDB" id="577156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="373" mass="41227" checksum="21C41F7D81AC06D9" modified="2014-06-11" version="1">MSARVRPPFRADHVGSLLRPPQLLTARADFAAGRIPAEELRAVEDDAIRTVVREQENVGLRSATDGEFRRTSWHMDFIYQLGGVHRADEQLTVKFRNAEGGIEFTSAALRVDGKVTLPSPIFADAFTFLKDQVGSATPKLTIPSPSMVHYRGGRAAIDESIYPDLDEFWADLSAAYAAQVRAIADLGCTYLQLDDTSLAYLNDPAQREFMASQGGDAEHQHERYIAQINTALAGRPEGLAVTTHMCRGNFRSSWAAEGGYDFVAEALFTQLDVDGFFLEYDDERSGDFSPLRFVPPGKQVVLGLVTTKRGALESKETLKRRLEEASKYVDLEQVCLSPQCGFSSTVEGNALTAEEQWAKLRLIVEVAEEVWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSP2</accession>
    <name>A0A010ZSP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose:LPS heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570162.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2795"/>
    <dbReference type="HOGENOM" id="CLU_038371_0_1_11"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="32954" checksum="511F0ABB05707721" modified="2014-06-11" version="1">MSTVLVLRALGLGDLLTAVPALRGLRRAYPGHEIVLAAPARFADVVAATGVVDRLLPTVARGREVPSRLDWDGTPPDVAVDLHGNGRLSRELLAALRPGRILSWVDGPAWRDDEHERVRWCRLLRWYGIASDPDDVRLDVVGTPGPGAVLIHPGADAAARRWPADRFAAVARAVAAAGLPVTITAGRGEGALAGAVAERAGLPPGAVVGGDGDVPFGALAGRVAGARAVVVGDTGIAHLASAVATPSVVLFGPVSPALWGPPAHPRHRVLWRADDPAALRPGDAHGTTPDARLLRVGVPDVLTGLGALGIPVDAALSGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSX4</accession>
    <name>A0A010ZSX4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569851.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1350"/>
    <dbReference type="HOGENOM" id="CLU_047737_0_0_11"/>
    <dbReference type="OrthoDB" id="1908280at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459172" description="SURF1-like protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27722" checksum="A8B86EC8F7CFB5F5" modified="2014-06-11" version="1">MYRFLLSPKWVAAFLLCVLAALVCVRLAHWQLDRLDQKRAINASITAARNASPMPPAAVLSTSSAPGKRQEYSRVQVSGQYDAEREVLVRNRTLNATLGYYVLTPLRTTDGPVLWVVRGWVEAGSGGATQIPTTDPAPGGTVTIIGRVRKPESGSTGSVQVSGRNLITRITPDALTAGGGSAYDAFVELVSPADPSLEALPAPDDLDEGPHLAYAVQWYLFAVMFIVGYGIFARNYAHRDDDPRATVAEPETVAVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT43</accession>
    <name>A0A010ZT43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1429"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="249"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="454" mass="47639" checksum="7D24EE895B4168F2" modified="2014-06-11" version="1">MVTTPPLAPNAAGKSPGRRSGRLRKRKLTGKGTGTVGVRRSLRLLRWRLTVLYTVVAGCGLIALATLAVNTDNHLRETRLDNSMETRARTAVALVYFTDSGIQLQDIRQDEVATGSPQLVVLLGYPPQRSVFASSDPALTVTASHLNGVAAQAIDLGGIVRTDGEDDRGHPTRLLAAPLYDNEGTAAGAVVVIGDPTDGDEEHEKLVAALILGCVTLVTLAALAGHALSGRSMRPAVDALERQEAFLADAAHDLRTPVATLRTLAEAALADPAQRSDLLPRAVALSARMGDIIDDLLTRARLNAGVQHLNKELLRLDLLVESIVDQLADPVGGPGARAQVTFHSEECTVRADAHLVTRAVANLVENALKHGHHPGVAPEVDVVVLRPGRITVSDRGPGIDPNVASALFGRFRSDGGSIGLGLSITLWAADLHGGKLTTAARPGGGAVFELVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT98</accession>
    <name>A0A010ZT98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851419.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3013"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_11"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="36"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="31849" checksum="FE0A017F0EC8006E" modified="2014-06-11" version="1">MARLLVTADYLHPGDAVDAYLRAHGHAPVHAPMTGRRGEDELAALLDGVEGALIANEPMTAAVLARATALRAVVRTGVGYDSVDVAAARRLGISVSNLPGINANAVAEFTIGLVLSASRHLVGLATGVAAGRWPRTDGRELRGSTLGLVGFGATARAVVPLARAFGMTVLCHTPRVPDDASGVEFVDFPALLARSDVVSLHAALNDATRGLIDARALAAMKPTALLVNTARGPLVDETALADAVRTGRIAGAALDVTAVEPLPADSVLRDVEGITVTSHMAGQTAQARAAAGREGAIELVAALAGEPAFRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTN3</accession>
    <name>A0A010ZTN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein, putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862985.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3156"/>
    <dbReference type="HOGENOM" id="CLU_107144_1_0_11"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16695" checksum="5140E6C1CD865479" modified="2014-06-11" version="1">MSGGVEWGLHCCVVLCGAGEPVPAAKLAKLHDVSPSYLAKQLQLLSKAGLVRSTQGQSGGYRLTRDAAEITMLDVVEAIDGPQPAFRCTEVRRRGPMAVPPERCATPCPIARVMDSADRAWRESLRVVTIADLAAEVDTTTPRELLDRARAWLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV05</accession>
    <name>A0A010ZV05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570569.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3685"/>
    <dbReference type="HOGENOM" id="CLU_052806_0_0_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35838" checksum="6DA2750BD56E2E35" modified="2014-06-11" version="1">MDELYPIGDVARRTGLSVTTIRFYADAGVVVPTGHSGAGYRLYDVRAIAALELVRTLRELGAGLDEIRRVLAGEAGVRDLAAHHLDLVESQISRLRTRRAVLRTIVRQDSAIEQVTIMHELATLSDDDRDRLVDGFWTEIAEGLDAGVLDDDVPPYRPRLPQDPTTEQLEAWIELADLVIEPGFRQAVRRYYEQLYAPEQDRAWSEEEIQRQVALLTEARTAAEAGQPVDAPPARELARRYVALVMSMDGGLDAAEARRLIAGAEPSAHVDRYRRLFDRYNALVAIINAITHRRAEAPGVTWLHEAVKALPDTPDHGARSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV27</accession>
    <name>A0A010ZV27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850212.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058026_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="51"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="1">
        <location>
            <begin position="146"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="256" mass="26790" checksum="243233E3600E90A4" modified="2014-06-11" version="1">MIKFALVIVAVSLLAACAAEDRGVVRAGPADPFSGRTFVSTGVTEGGTDRPLVDGTRIELRFAGDRTLGVRAGCNQMSGPVTIEGDTLRVGDLTTTDMGCDQPRMDQDSWFAGVLKAAPAWRLDGDTLTLTTERTEIRFTMKTSPPLVGTRWNVTGLVDGDTVASLPPDVEAYLEFDGTRVTGNAGCNRISGPATPGPDAIEFGPIVATKMACGGGRDTTERAVLRVLGAGTVRMVLDDTLRLTGADGTGITLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVG6</accession>
    <name>A0A010ZVG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2270"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="27416" checksum="F2AC4906ED0D9C97" modified="2014-06-11" version="1">MVTDFGGPLGPIQPRRSGRLGDTVVTYLVDRIVAGRYEVDSALPTEPELCEEFGVSRTVVRESIKLLEEKGLVRATPGRGTRVLEAPGWNLLDPIVLEAQIRHDRELGILDDLVSVRAALESDMVAVAARVITAEQQQALADQIEVLAAHLGDPDRYAAEDVVFHELIMAASGNRLGHAIIHSIHGKARLSSRYNGTPTVEGLDRSMGEHRQIEALIRAGEAERAGALMRTHIVGSWNRRRPAVHGALRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVJ2</accession>
    <name>A0A010ZVJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase/dehydrase and lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850463.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2295"/>
    <dbReference type="HOGENOM" id="CLU_131328_0_0_11"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="159" mass="17632" checksum="BA193F92F5AAAFAD" modified="2014-06-11" version="1">MPVVEASITVPVPPEVAFAVSQTTAPIRYRWDPFVREQHFVDGATAPGKGVRTFTRSRHGFTMVSEYVSFAPPTHVGMTMVRGPWFFERFAGGWRFAPAAEPGHTVATWRYNFQCRPGWLRPVAHRIGSRLLGRDIRHRIVGYAAGCADPVVLAAAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVS1</accession>
    <name>A0A010ZVS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3926"/>
    <dbReference type="HOGENOM" id="CLU_025182_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="385"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="524" mass="56707" checksum="B8AEC20616A8CD8E" modified="2014-06-11" version="1">MWPQLMTLAYGVVASIGAHTVVAAWHGRAHRVGVRPLAGLAGGIALLAVVACASTLTGDATTLRVLATIGILPQGGLIASYAVLVWTIGNPSWSTRWRIALLSIEPVVATALAATDGWHHLFFGPVAMNPLGVWVVQVGPLYWLHLMFLYFLTIWSTLHFGLADPAAPQKKKRKLGWMTAIALPPIVVNFLALEVVPLGVELTLIGMASTVVVLRVVLDRQSFDLRPVAREQVIDELSDYFCLVDRAGYVRDFNRAARQLLDGLDPELTRRHDIRIEEFGLGVQPDPERDTTTLVEDASGLGIDLEIRLIVLRDRAGACVGWALLSRDVTASHRQQRSLRRQLETIEALRAELAEQAVRDPLTGLHNRRYLADVLAVRSGGAAGERNCVALLDIDHFKRVNDTWGHAVGDDVLVGVARVLADGQPPGVVVARNGGEEFVLVFPGITADEGRARVEALRARVAARTFAVDGGVLRVTFSAGVAAADGRFDADALLEGADRALYRAKDNGRNRTETASADEFAPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW02</accession>
    <name>A0A010ZW02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of various ABC-type transport systems with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852848.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="27283" checksum="ADE7E19405B6F77E" modified="2014-06-11" version="1">MSELVFDHVTVRFRDHTAVDDVSLVVRSGTTHGLVGESGSGKSTMARVAVGLERAATGTVRLDGVDLARATGARRRVQMIFQDPFAALDPRMPVGASVAEGLLATGRKWSRADRVKRVRELLDLVHIDPGRAGERPARFSGGQRQRLTIARALAAEPAVLVADEITSALDVSVQGVVLNLLRELQAELDLTMLFISHNLAVVHYVSDDVTVLRGGRVVERGSTDSVLADPADPYTRELLRSIPVLGQPLDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW25</accession>
    <name>A0A010ZW25_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of polyketide synthase expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852889.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4045"/>
    <dbReference type="HOGENOM" id="CLU_017436_7_0_11"/>
    <dbReference type="OrthoDB" id="1452079at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="291"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="538" mass="57329" checksum="9DDF53E923EA3930" modified="2014-06-11" version="1">MEPGDVVARSTTILPPPNPQPRPVTLRELLGALGPHALRLVAGQRLDEPIGEPLIYGPGEPLPDVGDSIVFVTGARAGQPEALRRIAAAGGHTVVLKAWKQEIGDDHGLTLLCTPDEMAWRHLDALITTARLPGSAVNEPSGDLFSLANAIAASLGGPVTIEETTGRIMAYSNLPGQDIDPIRRLAILGRQTPERPTNAVEYQAVLTAPGPVFFESSHPDYADRLAVAVRAGHQVLGVIWVLCGRPQLVEDADRVLIDAARTTAMHLLRRRGSHDPDRTRRGEALRGLLADTLDAPAAAAALALPEATPVVVGVVRPVTQPGLHAARVADLVALHGEYWHSGAASVLDGDDLLLLLPGPASTPRLRKLGTDLATAARRSAGIALRVGFGPEVSGLDQARRSRQLAERVLLAGRPVAVLDDVRSELVLTALPDDDEALRLAPVRSVLEHDATQGTDYAATLLTYLGTFGNITATAQALNVHENTARYRVRRLTERFGIELGAGDETLVTWLQLRNACRRLQADTRRSVSDDSGRADPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWG3</accession>
    <name>A0A010ZWG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737156_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459197" evidence="1">
        <location>
            <begin position="31"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="375" mass="37152" checksum="156BDA77AFA164CE" modified="2014-06-11" version="1">MAGLRTTSAMLAAAVLLVGAGCGSEKPASAPAPAPAPRLAYADGSAVLVRAADGTAKRVAALPAGWRAEALTWSGDGTELAWIAADGEDVSRSRIYRAAASGSPVRHWDCALLCGGVEFLGSDLVGEGSLGGLESYPASGGEPEPFVPDGLPGASDLLGLSYRNLLTGSPAGDAIYVATGASTAAPKEVYRVGAGPTAVPVQPAGPTGLPLNATVSADGARLAYTVDGAVPACGATESVVVTDLGSGRATTLAPPSSTAAMFVAGLWFGDGDQVFAAYVPGPVPCVAGAAEQPDTPTRATTATVYERAGSTWKAAGRRARDGAHLGAGRALELVGTMTVGPSRIQQSPGGTLRLTGDGAPTVVAEDVTTFAVAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWN0</accession>
    <name>A0A010ZWN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotase-like cyclic amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851024.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2707"/>
    <dbReference type="HOGENOM" id="CLU_015572_4_2_11"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="323"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="487" mass="53263" checksum="7E7A1FBE0645C2A5" modified="2014-06-11" version="1">MNYDLIVTNARVVTPDAAEPRSTDVGIKDGKFTALGTLDPAEAGTVLDAGGKLLYPGVVDVHQHWGIYNDLTDDARTESRASAQGGVTTGITYIRTGQYYLNRTGPYTEIFPDVLKATEGHAYVDYAFHVAPILRRHIDEIPTMISEFGVPSFKIFMFYGTHGLHGRSNEQGSFLMLPEDETYDYAHFEFVMRGIQAAREDPRFAGFADAISLSLHCETAEIMRAYTKIVEEAGGPRDLAAYSASRPPHSEGLAITIASYLAHETQLPNINLLHLSSRKAIEAAMLMQTAFPHVNFRREVTIGHLVADISTASGLGGKVNPPLRPREDVEALWEHVLAGNFSWVTSDHACCKDEQKFGDPREDVFTAKSGFGGTEYLLPALVSEGRRRGLSHGQIAALTSWNPAQRFGLFSKGTVAAGYDADFCLVDDGSSWVVRAADSESAQEYSPFEGFELSVRVTDTYLRGDAVLRDGAVVGAPRGQYVRRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXE7</accession>
    <name>A0A010ZXE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851372.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2982"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="336" mass="36986" checksum="F276A4193C9AD5AA" modified="2014-06-11" version="1">MEYRYLGRSGTTVSELCLGAMTFGREADEADSRRMLDLFADAGGNFIDTADVYGGGASEEVTGRWLKDRDREQWVIATKVRFPSGPGVNDVGLGRKHILASIDASLRRLGTDYVDLYQIHGWDRATPLEETLSTLDSLVTAGKVRYIGASNVVGWQLQKMLDVSRAAGYERFLTLQPQYSLLARPTEWELIPVCEAEGLGVLPWSPLRGGWLSGRYTREMAGAPDGSRVKTAEAQGWSETWAAYANETTWSILDELRAIADARGRSVAQVALRWVLQRPGVTAPILGASKFSQLEDNLGAVGWELSGEELERLTAVSEVTAPYPYDASMRDLATNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXR9</accession>
    <name>A0A010ZXR9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570286.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3109"/>
    <dbReference type="HOGENOM" id="CLU_000788_1_0_11"/>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="275"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="823"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="904"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1332" mass="146816" checksum="E95D09B8226144AB" modified="2014-06-11" version="1">MDDGVLERAIEQKIGEWEQQLIDLSYKNNLLYFRQNGTSTLNLAEASAAAIERLLAGQVVRLSTLYPDLDTRSEVRTRVRSLAKKIRTIDEEQGINAGYIALGMASWRFADSLGVTKQPHAPVLLCPLRITPRSPTQEDFDLELRGPIEPNLVLAYFLRRQHGVELDESTLLGPDGTDAYGKLAEVQATLETAAGRLTDFRVDDALVLGFFSYEKLPIVRDLRASASVLAGHPVIAAIAGLPGAREALAAAPTGTARPGPDAITPSAEHLVLDADASQSRAIDAVLGGRHVIIKGPPGTGKSQTIANLIAALAAERKTVLFVAEKRAAIDAVVDRLNKVGLADLVFDLHSGAGDRKSVIAQVRESMERIGQAEQRQVGELHTRLSRDRSDLLAYRRTMHEPVMPWGLSPFDAQSELLGIPSALRTGVTMPLRAVRNLGGSAFDAVSEDLRRYLELDGLRITPDTTPWADASVNTAAEVEQLRQVLDDLVGSTLPDARRSLQNALDQTGLPRPASLSAWRVTLDLLERVQRTVQVFGPEVFGLPLEQLADASGSRRWRRGRSDQPGWRTRRRLVRELRDRRRDGQRKRAVLHRDLLLAISEREDWQTLSPTGAGPVSVAGLEEVLDHFNAAQRELTLVGAVLVTTRFDDLGDADAEQTVRRLHEDQQTLVNLPQLNEARRRLEAAGLGPVLAALQPLGVSVDEGVTRLRAAWLTGILAEMRAGVAAYRTFKAPVHDAASERFRTADRDHLREAAARVRYRVAEHLNNARNDYPAEKALVQKESRKVRNHPPLRKMLDGAPNLMLAARPCWAMSPLVVSQVLPPQRLFDVVIFDEASQVRPADAITSIMRGDRLVVAGDERQLPPTNFFELALATGGPNEEIDDDGVTLTDFQSILEVLDTGLLDQHGLTWHYRSTDERLIAFSNEHIYDRALTTFPGISAQRPISFHQVDGSAVAGQGGATEEVDAVVELAVDHALTTPTQTLGIITLGEKHADRIESKLRKVLQDRPGLQGFFGRPAEPGGNWQPYFVKPVERVQGDERDVILFAVGYGVRGATGTVNHNFGPLNKDGGERRLNVAISRARRRMTVVATFSSADLDESRLSKPGARLFRRFLHYAEHGEAVLRDGATEPRVLNGFEQDVLDRLSAAGLDPRPQYGVSGATIDFALPHPDQPGRMVLAVEADGATYHSSGSARDRDRLRQEHLERLGWRFHRIWSTQWFRDPEGEVGRVQEAWKAAVLTADAPAETPVTIPTAAAPAERRRTLPRPKFQPGQPISEYPPRDLLRIVKWVKSDGVLRDNEELLRAVMAELGFKRQGPRIKSAIGTAIQAARETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXZ4</accession>
    <name>A0A010ZXZ4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851653.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3182"/>
    <dbReference type="HOGENOM" id="CLU_642084_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459275" description="Peripla_BP_4 domain-containing protein" evidence="1">
        <location>
            <begin position="41"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="123"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="427" mass="45165" checksum="26A8EE024AE2F797" modified="2014-06-11" version="1">MGALSRPRRPRLRALIGLTALVAATALGGCTSSTTSSSDAKGDASEYAAAPLELSDAQRDEILKKAFLTDEIKAADLDPTIVQGLEEAGRDYSDEQVKAAAACLDKPTCTIGKGEQTLAILDGAGSDLWRRITRAQITVQATSYPNIGTVIYLQADGNLQTMQANLQTLIARKVTGIVTYDDFGPAMTAAYQQATNKGIPVVAYGGIPGKDATKAVVSQVASDFCDDGNQMAQTTAKMLNNTGNVAFFTGTPGNPQGAGWQACAETWFKQNAPNIAVVNRSNTSWTEGGAVSATTALISTGKKVDAVLYDYAKQTVNIVQTYQQAKQKVPAQVTWTSDNSLLQMWEKDLGTPNEWQLAYSSSINFEGAIALSALMNHLQGKDVPSMLMFPLPFVPAKKGDYVADQPANAPGPTLMPDALLSQVLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYR2</accession>
    <name>A0A010ZYR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570456.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3473"/>
    <dbReference type="HOGENOM" id="CLU_1987856_0_0_11"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="115" mass="13021" checksum="712DB67E0641E611" modified="2014-06-11" version="1">MAWSTRELAELAGTTVNAIRHYHRIGLLEEPQRRQNGYKQYGDEQLVRLRRIRLLVELGVPLARIAELGLDEALAPAVLREIDADHSAEVERLQRARCAIAVLLRDEAPSERSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ78</accession>
    <name>A0A010ZZ78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852388.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3678"/>
    <dbReference type="HOGENOM" id="CLU_039929_2_2_11"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="31035" checksum="3AE75D408A967717" modified="2014-06-11" version="1">MDALITPLLNGSAQGALLLLAALGLSLTFGQMGVINMAHGEFLMIGAFTAYLVQQVIGAGDLSIPVALPVAFVVAGLFGLLLEVAIIQWMYRRPLDTLLVTVGVSLILQQAALQIFPSQGVPVEKPHWLDGQLNVLGYDWPLRQLFTIVLAIGCVAALAAWLKYTAFGRRIRATVQNRDLAETSGIATRTVDRLTFFAGSGLAGVAGVAASLIGGTNSQMGTQYIIPAFLVVAAGGIGQLKGTIIAAWAVGVALAYFADWTTGSLAQVLAFILVIVFLQLRPQGLFTVRTRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ86</accession>
    <name>A0A010ZZ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852400.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2080868_0_0_11"/>
    <dbReference type="OrthoDB" id="2023106at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="12915" checksum="38E03DEB815184D6" modified="2014-06-11" version="1">MSDSDAATVRELEAVIAEVATGLWRLTARLGDAPERDRRPVERLVEVLADRGIRVHDPRDRPFHPGLPVEVVAYQPTPGIREETVIDVERPTVYRGASVLQRARVVVGVPDEEVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZF5</accession>
    <name>A0A010ZZF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3764"/>
    <dbReference type="HOGENOM" id="CLU_136765_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="16173" checksum="96904FDCED6244FB" modified="2014-06-11" version="1">MTFNEAIEAVGRGIEVAGAAVMVVGALGALVVALRGLRRAEPDTYRSFRQQLGRSILLGLELLVAADIIRTVAITPTLESVGVLAGIVVIRTFLSFSLELEITGSWPWQPGSEQRDRQNEHGEPDQAPREAGGRELPVPEARRPGGDAHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZU1</accession>
    <name>A0A010ZZU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid/amide ABC transporter ATP-binding protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864939.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3913"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27547" checksum="84B687601CDD1A11" modified="2014-06-11" version="1">MTSRVAVRTRALTKEFRGFRAVDAVDLEVREGSVHALVGPNGAGKTTLFNLLTGFVAPTSGAITVFDEDVTGEPPERVARRGVARSFQITSLFETLTSREHVELALAGRTGRGFRFWRSEKLLGRERPRVDALLAEVGLAPLADKPVGLLAYGQKRALELSLVLALDPRVMLLDEPTAGMGTEDVDRTIDLVRRIAAGRTVVLVDHNMHVVGSLADRVTVLQQGRVLAEGRYDEVRVDERVITAYLGRAEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABL3</accession>
    <name>A0A011ABL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848033.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.430"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="29674" checksum="E09174C1FE16658A" modified="2014-06-11" version="1">MRSYGWRTFALEFVMLAVTVAFAFPLYVLVNLSLRDPRDTASAASLTTSPTGRNYADAWSQAGLGGAIANSALVTIASVVIIVLVSALAAYPLARSTAAWSRATFLLVMLGLLLPFQLALLPLYQTIRDLHLLGTPWALVLFYSGLQVPFATFLYVGFLRALPRDYEEAALLDGCSPFQAFRSVVFPLLRPITGTVVILNAVLVWNDFLTPLLYLSGSTQQTIPVAIFGFLGQYSSQWELVFAGLVVGSIPILIVYFAMQRHIIKGFAGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABM6</accession>
    <name>A0A011ABM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMT(Drug/metabolite transporter) superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.445"/>
    <dbReference type="HOGENOM" id="CLU_033863_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="32270" checksum="057E8BE02D5A343E" modified="2014-06-11" version="1">MGITGRAALVRLAVLAVLWGSSFLWAAIALRGLPPGVLTVVRLALGSALLLAVCRLRGIRLPTEPRVWLHLAVVAAIGNVVPLLLFAYAVRSIDSHVGGMLNATTPLWTLAIGVCLGGLGPVRGRYLGGLLAGLVGTLLVIGTWPPGEGLPVVPTMLGLMAAASYGASYVYIDRYMSRLDRPPIALAAGQLVAGTGLALIALPVTGPHSLDAVHLGPDVIVATIALGAFCTGLATVLNIRQVADVGPAASVVLYLLPVVAAVLGWLVLGEKITPLTVVGTAIVLAGVALTRTPQSNAEERAAGGSGSRLRAGTDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABS7</accession>
    <name>A0A011ABS7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848172.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.507"/>
    <dbReference type="HOGENOM" id="CLU_104555_0_0_11"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="173" mass="17916" checksum="D45939BFE8FE7F6A" modified="2014-06-11" version="1">MPETLTWLPAADHPELLAPPVAAVVKHLSEVQVAAIDPTDADTEAFCARYGEPLEESANCVVVAGKRGGVVKYAACLVLATTRADINGLVRRHLDVRKVSFAPLDEVVDITGMAYGGVTPLGLPSDWPVLVDAAVAAGRSLVIGSGVRGSKLRVPGATLAALATADVLEDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC02</accession>
    <name>A0A011AC02_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DivIVA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017257_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="408" mass="43952" checksum="8B97D8BD931D171C" modified="2014-06-11" version="1">MSLDDHVWIERMAQGEEQNLFTLSDPATAEVTFDLALRGYDRRQVDRYIAQLESELSQFAARRDDALAQNHALAAQVGELQNQVVEVQRRPTAEKPSYKHLGARVEQIFAMVEDEAAEIRSKAEADAAALRSKAEQDIEAVKAGVEKSFAERREAIEAEYAQKTAHADKLVAEAEKRATAVGREAEEARAKGEREVGELRERTKADARRVQDDASQFSARVRGEAEKHAADVLAKADAHSADVRRKADEAARGATDAARRQAEQTITGARTEAESIRASAKTDAEQMVAEARRVVAELDTRRKQIKQEIGRLREAVARLTGGGAGLFGEDDVEEAASAATLKPEAPAGPAAAPAQQPKPSQQATPAAAATTQRMAVPGPGQPPAAPNNGIGPHRGAPTNEMPRVSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD41</accession>
    <name>A0A011AD41_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848734.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1008"/>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_11"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="311"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="429" mass="45079" checksum="B2CB7BBB2C89EF19" modified="2014-06-11" version="1">MRLTVIGTGYLGAVHAACMAEIGHDVLGVDVDEAKIAALAEGRAPFFEPGFPEVLKRNLENGRLRFGTSLAEAGAFGDVHFVCVGTPQRPGSHAADLRYVDAVVGGLAPHLRPGALVVGKSTVPVGTAARLADSVPALAWNPEFLREGFAVEDTLRPDRLVVGVTSAADEDVLRAVYAPILAAGTPWVSTDPATAELVKVAANSFLATKISFINAMAEICEAAGADVTTLAGAIGYDARIGDRFLRAGVGFGGGCLPKDIRAFRHRAAELGLADSVRFLHEVDEINGRRRTRAVDLARELVGGSFAGTSVTVLGATFKPDSDDIRDSPALAVANAIRAEGAQVTVHDPQGIDNARAVYPDLDYSPKAQKACEGAHVVVLATEWAEYRELDPAAVREVVAAPALVDARNALDLPAWQEAGWDVRALGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADH2</accession>
    <name>A0A011ADH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569798.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1144"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="375" mass="39753" checksum="22305440EE4172B4" modified="2014-06-11" version="1">MRLGGWELRARDVASALGVFVGGLLLFKFGYPLKSWVGVATLGASAVSLLFIRSYAWFSLTIAAVALTIDWIVGPNLLTICVFANAAYVVTEQGSARVGRAMMIGSVAAVLIFTGVGLVIEGELTGVLLGVQAALFTVLPVDTAMTVRRHRQTAAAERERAEQTARLAELDQRAAVTAERTRVARDLHDLVANDLSVIALHSTAALARDDHGDTTRRSLELIRKHSVDGLAEMRHLIDVLRAGDGADSPAEARLDQLDALVERAREDGTPATLTVDGEARPLSPAVELAGYRILQEALVNAGKHAAGQPVEAVVRYRPDALTLTVENRLAAADSSFPLVGGAGLVGMTERAALVGGALDAGPREGRWRVHASIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE40</accession>
    <name>A0A011AE40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="338"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="476" mass="50011" checksum="4AD61AE70D67184E" modified="2014-06-11" version="1">MWVTALLVGAAIIGVYAFDLPDLVHAALYTAVSAAAAVTVFVAVRLHRPRVRLGWWLLGAGQAAATCADGIFFGWPALVAPLPFPSVADAFYLAQYPLSAAGLLLLVRSRTPGWDIPSIVDAAIVTASAALLSWVFLITPAAASGTTLAGSVVAASYPASDLLMLVVAARLLLGAGDRPVALRLLAGYLAALFTADALYALQVNAGTYQAGGRLDLIWMASSTLLAASALHPSMRTVDVQAPAAPPLVSSPRLALLAGASVLAPATLVVQHVREAPLHVYLVASTCAVLFLLVVARLGHQVDVQRQLAITDGLTRLRTRRFFDETLDIEVGRAERDARPVALLLLDVDHFKRINDRYGHGVGDLVLVEIAERLRKCVRTGDVVARYGGEEFAVLLPGASPVDASMIAERIRAAVEATPIAVPGDTSITTTVSVGVATLPANVSTSSDLVLLADKLLYTCKEAGRNRVATPSGLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AED7</accession>
    <name>A0A011AED7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193211_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458508" evidence="2">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="232" mass="21171" checksum="E672E8C95A3347E5" modified="2014-06-11" version="1">MAPTAMALAVMRSAALPTVTRSEAAMPIGMRSATRVTAAMAPTSLLPANPGAASPGVVSPGVVTPKAVSPGVVSPGVVSPGVVSPGVVSPGGVNRGAVSPGVARLVAVSPGAVGAPVGSRVVASPVAGTRTVASAEPVSLVSPVAGIRFGTPAIGVAALGSPAAGMPAIGSTAAANPLIGTRFATPAGGAATPAGGAATPAGGAAAPAGVTATPATATPASEASAGGPPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF69</accession>
    <name>A0A011AF69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849684.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1731"/>
    <dbReference type="HOGENOM" id="CLU_040940_5_0_11"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="21100" checksum="E5097DC4BA1929C0" modified="2014-06-11" version="1">MDVDAILLNVRAFRPTSLPSEGLRRAAVALAIAGDRPAIWLTRRTSELRAHPGQFALPGGRFDPGEDAVDAALRELGEELGVFADRSTCIGTLDDYATRSGYVITPVVLALGVVPPPVPNPAEVAELYTIPLADLDVEPRYLRIPESDDPVIQLPLVGSLIHAPTAAVLYQFREVALHGRPTSVAHLEQPVFAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFH4</accession>
    <name>A0A011AFH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849799.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1803"/>
    <dbReference type="HOGENOM" id="CLU_041115_1_0_11"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="207"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="41462" checksum="658C871A441918B4" modified="2014-06-11" version="1">MREVLDDLFGWWDAGKSVGVGTVVATWKSAPRPAGASMLVGPDGTAVGSVSGGCVEGAVYERAQEAIATGSPGLERYGVSDDDAFAVGLTCGGILDIWVERIDRESYPEFGDVVASVRDGAPVAVVTCVASAAAPTGDDRVGHRLVVWPDRVAGSLGSARLDEAVTDDVRGLLATGRTTTVHYGHDGERRGDDLTLFVSSFAPRPRMIVFGAIDFAAALARIGAFLGYRVTVCDARPVFATAKRFPDADEVVVEWPHRYLRAEADAGRVDERAVLCVLTHDPKFDVPVLEVALRIPAAYVGAMGSRRTHEDRLQRLREAGLTAEESARLASPIGLDLGARTPEETAVSIAAEIVAGRWGGSGARLSTLNAAIHRDTDLLHRDEEELSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFI6</accession>
    <name>A0A011AFI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849838.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1823"/>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="338" mass="35756" checksum="BFFA729742800E2B" modified="2014-06-11" version="1">MATFTSKDVARLAGVSQSTVSYVMSGKRPISEETRRRVLDAIDRLTYEPNAGARALASQRTKVVGLVVPFGVGVDTTGLLPFIETIAGAARARDHDVLLVTADEGSAGIRRLAGRSLCDAIILMDLQTVDDRLAVAANVRTPVILIGVPADPHGMHCVDLDFAEAARLAVGELAATGHDRLALIGHPADIVLRDLNYVRRFADAARSAAAGHGLPLEIIAPVEWGREAAGDAAARLAAIDARRLGVVVPASNTVQPLLHALNARGLVPGRDLSVIGLLTDAAAAEGEPPVTNVSLEPRDVSRRAMQTLFRLLEDRTAPPLIDLITPQLTRRQTVLPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFP5</accession>
    <name>A0A011AFP5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CryarDRAFT_1936</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849945.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1899"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_11"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="340"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EXG80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="459" mass="47697" checksum="ADFBD3D7244F5683" modified="2014-06-11" version="1">MVGGGPAHDLVVLGGGSGGYSCALRAAELGLSVVLIEQDKLGGTCLHRGCIPTKALLHAGEVADTTREAARFGIRAEFRGVDLPAVLAYQDGVVTKMFRGLTGLVKSRGVTVVNGRGRLTSPTTVEVDGETYEGRHVVLATGSAPSTLPGLEVDGRRVLTSDHALRLEQLPASAVVLGGGVIGVEFASAWRSLGVDVTIVEALPRLLPAEEESSSARLERAFRRRGIGFRTGVRFASAEPTDAGVRVRLSDDSVLDAEVLLVAVGRAPVSAGLGYEEAGVALERGHVVVDPLCSTNVPTISAVGDLIATPQLAHVGFAEGILVAERVAGLPVVPIDYAGVPRVTYSEPEVASVGLTTAEARARGYDIDEVQYDLAGNGKATILRASGAVTVLRAKDGPVLGVHLVGSRMGELVAEAQLIYNWEAFPEDVAPLLHPHPTQSEALGEAHLALAGKPLHVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFV2</accession>
    <name>A0A011AFV2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850032.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1583751_0_0_11"/>
    <dbReference type="OrthoDB" id="558757at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="17903" checksum="2B8D7AF041DD0C58" modified="2014-06-11" version="1">MTIPSDDELTRFHGPPVVNVEDGVRAGIEGAAWRVSPGYDEGVRTMPGRISDLIDRAPVRALVIDNWGDPAESALPVTEIAASASRLPGLRALRVRGSQNLETQPVKHTALRERVFGNGGLPAEVTRAVATPILTGERLGGALPDARIDASESRFGEADDERYVAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFY4</accession>
    <name>A0A011AFY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="250" mass="26494" checksum="7B24EBDA1C09BEA3" modified="2014-06-11" version="1">MPEQARTPLNRPQRTLSPHSHPQAGTGKAAAAGTDAKEHVSDVLVRVSDAELDGRLGRPEAARGVVVFAHGSGSSRHSPRNRQVAKALYRAGFAVLLVDLFTAAEEQEDQRTGRMRFDIDLLARRVDDSVGWVVEHTDTQGLPVGLYGASTGAAGALAAAAQRPETVRAVVSRGGRPDLASSWLTTVAAPTLLVVGALDHPVLELNRQAADALGGLARVEVVPGATHLFEEPGCLDHVATHTTAWFQQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH07</accession>
    <name>A0A011AH07_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570049.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2349"/>
    <dbReference type="HOGENOM" id="CLU_079614_0_0_11"/>
    <dbReference type="OrthoDB" id="1175086at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458399" evidence="6">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27180" checksum="10AF44CBF33FF2E4" modified="2014-06-11" version="1">MRGPQFWMRRLAASIGAAAVLVTAACGSPSAGSGSPATGGAAPAGASPTTPVSAAASPSTEFDTEFTQALELVTAYWRQEFTANNVAFAPVKDVRPYTKDGELSCAGQPLSTNNAFYCPPSDLLGYDVNFVRAGYDKIGDGFLYLLLAHEYGHAVQTRVNTNRLVSRVYELQADCLAGAVIGDSTRAGTIELERGDADEIMTSIMTIADPDGVPWFDPTAHGSNADRLAAFSRGYRSSYGACHLDSLSGVRLVPSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHA4</accession>
    <name>A0A011AHA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850698.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2471"/>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_11"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="364" mass="37037" checksum="3642DE831BC436BD" modified="2014-06-11" version="1">MSSGRPRVALVLASSTGGVGKHVRSLAGHLVASGHRVDVHGPAATEELFAFRSAGAGFSPVEIPARPNPLKDATALATLRRRLRADRPDVVHAHGLRAGLVAAAAGRRPLVVTWHNLLMAGNPVLRGLERVVARSADVTLAASDDLIGRALRLGGRDVRPGPVAAPTLEPPVTSRDEVRAALGVEGPLVLTVGRLHPQKRLDVLVDASVRWGGATVVVAGSGPEEAALRARATAKNAPVRFLGHRTDVADLLAACDVAVVTSDWEARQLFAQEALRAGRPLVATAVGGVPGLVGDGARLVPSGNVDAVAGAVSALLADPGEASALAARGARIAAGWPDEATVAAHAAAVYAELAGADVPSQAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHE0</accession>
    <name>A0A011AHE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillin-binding protein, beta-lactamase class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850768.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2511"/>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_11"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="411" mass="44557" checksum="5204FFCB3362F7BD" modified="2014-06-11" version="1">MTNAVVEVEPLAVGLDPGRLSRLDRHFARYVDDGRLPGWSVLVSRHGQVAHTSSYGLRDVEAGRPVTDDTLFRIYSMTKPITSVAALMLYEEGAFELTDPVSRYLPAFAEQRVLVGGTAAKPVTVPAIEPVRIWHLLTHTAGLTYGFHHVDVLDEIYRANGFEWGTPRGLDLAACVDAWAGLPLAFQPGSEWNYSVATDVLGRLVEVVSGQTLDTFFADRILGPLGMTDTAFSVPEPEADRLAALYTPSPAGGLVRSDAMGRAVLTPPRFLSGGGGLVSTRHDYHRFAQMLLRRGELDGVRLLGDRTVRFLGANHLPGGVDLEQFGRPLFAETPFRGVGFGLGVSVLLDPVVTRTLGSAGEFGWGGAASTAFWVDPAEDLVVVFLTQLLPSSTYPIRSQLRQLVYSALVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHL4</accession>
    <name>A0A011AHL4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850854.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2591"/>
    <dbReference type="HOGENOM" id="CLU_020211_11_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459583" description="Histidine kinase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="296"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="522" mass="54680" checksum="C2C0940A79D4BF03" modified="2014-06-11" version="1">MALRPQEWSLARQLFALQIAVVTVVVAAGLGAAVVQAEHSTEENAATRALAIARGVAATPDVRAALSLPDPTSVLQADAEAVRRATGTDFVVVMNTDGIRYSHPDTTQIGGKFLGHIDAGLRGEDLTETYTGTLGPSVRAVVPIRADGRVLGLVSVGIKRSAIDRSLQGQLPLLALAGGLALLVAAGGTGLVTRRLRRQTHDLGPRELSRMYAYYDAVLHAVHEGLLLLDDKGRVQLVNDEARRLLGLPADVVGLPVADLPLGASLSKGEDQTDELHLTGDRVLVVNQRRAAGGSVVTLRDHTDLQALTGELDSVRGFAESLRSAAHEAANRLHTVVSLIGLGRVTDALEFATGELALSQQLADRVVEAVEEPVLVALLLGKVAQASERGVELVLDPEAAVPPGVADPRDLVTIVGNLIDNAVDAAVAAPPPRRVEVAAWVVGEELVLEVADSGTGLDAEQVEQAFARGWSTKTDERLIGRGLGLALVGQAVHRHGGTIDVTGDAGAVFTVRLPTRARVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHP8</accession>
    <name>A0A011AHP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2626"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="26482" checksum="3AAA27C7BE4FC7C0" modified="2014-06-11" version="1">MSEMSPAGRRASRRKPLERPAPLRQVVTDEIADMIITGELQPGEHLVEQELAAQLGVSRQPVREALQRLHSEGWVDLRPGLGAFVHTPTADEADQLLATRTLLEAESARLAAANATPALVEQLWQLQAVGEQAVAADDDAGMVAANAALHRQIMEMSGNTVLGELIALVDSRVRWYYRPIARSRGREAWDEHRELIETIAGGNARKAGELMRKHTERTRKTYHVRAADAEKTPASPVEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJV0</accession>
    <name>A0A011AJV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2492618_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="86" mass="9486" checksum="AE4E0C4A10588F75" modified="2014-06-11" version="1">MCWSRWCGLRGAAGRSRPERREHRRAQSALVAARAAAAETAGCEVLVAETYVPPVEGTNPSLNNMIRAGFEVLYVRVNQVWVDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJZ9</accession>
    <name>A0A011AJZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851979.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3418"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_11"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="41919" checksum="8377E981CFBA8280" modified="2014-06-11" version="1">MQGRPLEGIRVLDLTNVLAGPYCSYHLSLLGAEVVKVEAPGRGDLARQLGPDAELNRAGVGASFLAQNAGKKSIELDLKDSADRETFTRLVSGADVLLENFRAGVLARMGFPWEQLRALNPGLVYCAISGFGQTGPMSQAPAYDQIIQGLAGMMSITGTPDTVPMRVGFPVADTVGGLTAALSITAALAARTRTGEGAFLDVSMLEASLSSMGWAVSNYLISGVAPEPMGDQNATAAPSGTFETADGPLNIAANRQEQFQTLCRLVGREDLLVDARFAEREARKAHRTALNAELNTALRVRTAREWEEILSAAGVPAARILTVPQAVELDQLDHRCFFTEVPFPGADGRTARVSGSGVLFDGEPLRPPGPAPVLGSDTARIPELLARWGTPAEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKP8</accession>
    <name>A0A011AKP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852417.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2664938_0_0_11"/>
    <dbReference type="OrthoDB" id="2232591at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458417" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="75" mass="8178" checksum="6EB0CD2B4B809A8B" modified="2014-06-11" version="1">MARLLTRMGDTMLAAMLPKARASACGIMCRHAYTACGGSSCVYYWNKYVSGGQYCFAMRENSCYSTPYSTSPGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG71</accession>
    <name>A0A010YG71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with putative antiterminator output domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.249"/>
    <dbReference type="HOGENOM" id="CLU_074354_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="239" mass="25368" checksum="FD5ECCA1242B0804" modified="2014-06-11" version="1">MDDKSLATGLTGLAGLLTGHRALPETLTHIAQFAVQAIPGAEGAGLTMLDDDRPQTVVASAEFVRVVDDVQYGLAEGPCLLAVATRQTQLSGSLGGERRWPRFGPRAGRMGVHSVLSLPLLLPDRVIGALNVYAHEKDAFGPDAERIGELFARPAAVSGHNAQVLARSQQLATQLGEALTSRAVIDQARGILMSRTGATPEEAFDQLRTMSQAQHVKLAEVARTLVAEAVRRARRPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH89</accession>
    <name>A0A010YH89_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848408.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.672"/>
    <dbReference type="HOGENOM" id="CLU_033626_0_0_11"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="396" mass="43620" checksum="2F0843F97E7BF997" modified="2014-06-11" version="1">MDTDVCVVGGGPAGLVLGLLLARQGVDVVVCEKHEDFLRDFRGDTVHPSTLDLLAELGLSKEFDELPHRTLERLALDLPDGVWPVGDLTRLSNPHPYIALVPQWDLLEMLARAASHYPTFTLLRACEVTDVIRENGVVTGVRTTQGEIRARLTVGTDGRHSTVRRALGLRSRDFGAPMDVAWFRLSRHDSDGDGLIGHVRKGRILITIDRGNYWQTAYVFPKNGFEQVKRDGLAAFKASITDLAPFLGDRMDEITDWDPIRILTVTVDRLERWHVPGALLIGDAAHAMSPIGGVGINLAVQDAVAAARILAAPLNERRLSSTVLARVQRRRTLPTVGTQLFQRLAQNAVIRPVLSGGRPVTAPLPLRLLRRFPALQVIPARLIGVGLRPEKLVDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHT6</accession>
    <name>A0A010YHT6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569725.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.870"/>
    <dbReference type="HOGENOM" id="CLU_052511_1_2_11"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="18073" checksum="ACCF899C0EA7CFA5" modified="2014-06-11" version="1">MPESARETFALTVNGTTHHLTVDPRTTLLDALREHLSLTGAKKGCDHGQCGACTVLLDGRRVNSCLILAISQQNARITTVEGLGTPENLHPVQREMLEHDGFQCGYCTPGQVCSAVGMLGELNDGWPSAVTGDTPQLSREEVRERMSGNLCRCGAYPNIVDAIVEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJI3</accession>
    <name>A0A010YJI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849247.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029405_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="28362" checksum="7B5F78BC810438CB" modified="2014-06-11" version="1">MQPGPPYGPPSYYPPPAYPPATPYGAGPLPGQPLPPHLAYAPPPAGLRTVKRSRTSAAIALPLVGLLIVGIVCPSLPWVDTGPETFNLWDLMGNLWDVGGDAMKTWSSQYFGYVWLVIAVWAFFLSMAGTTDNAGWRITYGVIYVLIGLAFFGSTVLSLVLVGAAAGAMGSEFNTEGTGLAVGVVGVILLVAFVVYVGVAILLFKLKGAGYRILAGLGLLSFAAVHFSALASLPEGAELEPGAYLSIFGYLLCAVGCFIGPKYFHVHRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJS9</accession>
    <name>A0A010YJS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase, CocE/NonD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849416.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_5_1_11"/>
    <dbReference type="OrthoDB" id="327988at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="293"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="511" mass="54788" checksum="55A7A9EE95CEF8A7" modified="2014-06-11" version="1">MTPRLNLRVPGEDGTPLATDVYPAAAPAPVVVTRTAYGRSAHRAEGQAWAARGFAFVAQDVRGRHDSDGAWSPYRNERADGAALIDWVLRRPWCDGRLVTTGGSYAGYTAWAAAVTRPDAVRAVLSTGPAMGLDRVKFDPAGILRLAEHATWWLTRAESRTSREGLVTEVARRDPQWLHHLPVVGIAERMWARLEHWSDTITGGPGAEGPEAITDAELAAFPGAAFHVGGWYDLLLAETLRQWDVVGSAVSPRPGRQLLLGPWDHGFVWAPTTRIGGRDHGPDSRIPLGPRQVRWLREILGGARRSRADVFVVGAGWSSSPAWPPPTAPTVLWATGDDTLADTPPDTGSARTYVYDPKDPLPSSEPGADRAELEGRTDVVRWCGPALDQPMTLAGTPCVVLSASTDAPATDFVVRISERTTDGRVLPLASGAVDTSRSAGPAHRIPLTPIAVRIPAGSRLVLEVTSSDFPYLARSLNTGADRYTTTDTVAATQTIHAGPGGTRVELPEQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJV6</accession>
    <name>A0A010YJV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1582"/>
    <dbReference type="HOGENOM" id="CLU_027853_7_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="30916" checksum="6AE986244E2FD27D" modified="2014-06-11" version="1">MVKLGINIPNFTTSPREMRDWVKFTQDHGFTLAMMSDHVAVTPQVADLYPPPFYDPFTTLGWVAGYADGLELGTTVTILPYRHPLLTASMAAALHDFTDGHFVLGVAAGWASDEFEALGLDFAGRGRASEEYVAAIRSALRDEVTSASGEFVDYRDVATGPARHTPIWIGGTAPAVLRRAVAHGDAWHPNNAPLDWLRDVGLPKTQGVAFCPRMRARVTAHDSAPDRAPGTGSLDQVAADFRTLIELGAEYVVLDSNPDHPRDRLPAAEDFRTLAALADRLIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKQ9</accession>
    <name>A0A010YKQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_1887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569959.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1853"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458117" evidence="7">
        <location>
            <begin position="33"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="6"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="50687" checksum="19586068C8FF51A8" modified="2014-06-11" version="1">MRKWLPLTAVSLSTFMLLVDLTIVSVAAPALADELHSSFAALQWTVDLYVLVLAAFLMAAGSLADRLGHRRVFVTGLIVFAVASLACGAAPNIEFLIAARGVQGLGAAAMYGTNASILGLAYSGRDRSVAFGIWGAANGAAAAAGPLLGGVLTEHVGWRSIFLVNLPVAVAALLLARRSVPGDRQAAGARLDLPGVCAFTAAAALLVYGLIRAGDAGWTDGGTIAVLAAAVVVTVVFLVLEKINDDAMLDLTLFRRPAFSVAVFAAAGLTASAFANLIFASIWAQSVLGLSAMDTGLVLAPMAVVGFVVAGGGGRLLHGVPARYSIGIGLLLVGAGNALCLLVGPSSSWGALIPGLAVTGIGVGLSTPVLASAALAAVPPQRAGMASGASNTARQIGYAVALPIFATLVTGAADDVLGDRAAAKALTGGGYAELVGRIPEAVLRTAYADGLDRVFLTSAIVAVVSGAAVLVLLGRRYPLGDDRQDRVDSSPGRPDSEHPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKS3</accession>
    <name>A0A010YKS3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1873"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="208" mass="22364" checksum="C808BCC5794ABAA8" modified="2014-06-11" version="1">MIRVLIADDQEAVRFSFRTILNAAPGMRVVAEAENGTRALELADEYKPDVALVDIRMPGLDGLELTKVLSPTIKVVVVTTYDLDAYVHTALRNGACGFLLKHSGAALLAAAVRAAAAGDALISPEITVRLLRELSPRTADANPLTDRELDIVALVADGKTNAEIGADLYITAGTVKTHLAHIQQKLDVPNRVGIAAWAWETGHRRPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL49</accession>
    <name>A0A010YL49_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_2055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850091.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2020"/>
    <dbReference type="HOGENOM" id="CLU_063626_2_1_11"/>
    <dbReference type="OrthoDB" id="1942709at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="26362" checksum="F24DADB793350121" modified="2014-06-11" version="1">MTWQFEGSQLVALLLATVRASAWLIVVPPFAAPMISARIKAILALTIALAVGPAVQSQAPPLEWAPLVSSAAQQVVVGAALGYITALLFTAFQVAGDLIDMFGGFQVAMAYDPMANTQTAPFGRFYNLLATTLLFATGGHALIIRGFAESYDAVPLTGILSFSALGHVLTEGIGQMFLAAMQIAGPLIAVLFCTDVALGLLTRAAPALNAFSLGFPVKILMTMLLGGLAIGIVPGMVEEVVDTAVVAVMTVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLH4</accession>
    <name>A0A010YLH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850237.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2141"/>
    <dbReference type="HOGENOM" id="CLU_014801_4_2_11"/>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="52019" checksum="F17BAFEAC3139956" modified="2014-06-11" version="1">MSEVLLDGAALTAEQVRSVARHGARVIVHEDGLIRASAAHESIRALSAARPVYGRTTGVGANRLVAVEYESSAGPVVLGPEGSVVPGDAAPEPIVRHEPHGLRLLRSHAGGAGPLLDPVSVRAMLTVRANQLAAGGSGVAPHLLTALAEALNRGAIPPVHAFGGIGTGDLPALAVTALCLLGEVPWRGGAMEAVPFDPADALSFISSNAGSIGEAALACADLSELLRASTVITALAFLACDGNSEAYEAVVHLARPHPGQQTVAARLRDLLAGQPVKAARIQDPYSYRAVPQVHGPALDAVVALERTMSIELNAAAENPLVDSVGRRVLHNANFHTAYLGLSLDAMRNALYQTAALSVARLSLLLEPAFTGLAPFLAAGPPGSSGLMILEYVAHSALGALRLHATPTSLATAVVSRGVEEHAPFSSQAARNSLDAVGSYRIVLAAELVAAVRALRMRGTPPVDGPLAEAFAYAAERLPDRLDDRPLDQDVEDAAGLLPALAGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM01</accession>
    <name>A0A010YM01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850486.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2308"/>
    <dbReference type="HOGENOM" id="CLU_027335_0_0_11"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="512" mass="55163" checksum="8BE8E24F3CF5ED21" modified="2014-06-11" version="1">MNLRSVAVLGGGPGGLYVARLLKLSRPGCSVEVYEQSPPGQTFGFGVGLATRTQRNLDAADPASFAEIVDNAWAHDMAMAVGDRKVTLPVGNLIAIGRSTLLDILRRHAEAAGVRIHSGARVSAADLDADLVIAADGVNSATRTAGFGPEISTHRGLYLWAGTDFALPSAVFRPVTTEFGTFVAHAYPYRADRSTFLVETDEDTWRRAGFDVSTEQTALDASDEHSLGYLAKAFHDELQGHPLIGNRTRWLRFRTVTCARWHDGNVVLLGDAVHTAHYSIGSGTKLAMEDGIALVRALDEADDLPVALRQFEQERRPAVEHLQATAHRSMRWWESFPDRLDLPVEELLIAYMTRAGKVTLDRFGALAPDVVRAGLAQYAGCDPADVPDSDRAPWVLSRHPRARSTAIPTTAGVPTTADAAGSAPDNAPLHVGCADAWGPAAEALFARVRGSSGPVVLVADDDREAVLTLFDVGERVRRETASVVVARVNRRWSEFAAAALVSGRVDRVDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YME2</accession>
    <name>A0A010YME2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein, putative virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2470"/>
    <dbReference type="HOGENOM" id="CLU_006797_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="567" mass="56577" checksum="3BAFBC03293905F6" modified="2014-06-11" version="1">MPDTAAAPDDTGSPPPRARRTRTLLGAAGLIAGLTVVARIVGFGRIFVFAGAVGVTSVGNIYQAVNTIPNIVFEIVAGGALAAVVVPLLAGAADRGDRATVDRITSALLTWAVLLLAPLAVVIAVAAGPIVDALLPGASAADGEFGRLLLRIFAPQLVLYGVGIVLTGVLQAHRRFAGPALAPLLSSVTVIAAYLVYGWTEGGAATASDVGLGGQLVLAVGTTLGVVVLSLSLLLPLRGTGVRIRPTLRFPAGVVGPARRMVGSGVATVAGQQVALLVVLVLTQESRSAPVGSLVVFTMAQTVFLLPWAVFAVPLATSAYPRLASAWEGSDRAGYRDTLRTTLHGTLVLCALATAALIAGAGPIAAVVTAAGNADAGRAAVATGIALFAPGLLGYGLFALLSRALYAAGRPWPVATAVLGGWAVTAVADVVLAFALPAGDRVAALAAGNTIGMTVLGVALLVLTARTAGTGAFRGLGRLAAALVPATVLAATAGAWVASVLPGAGVFAALGAGVVTAIVVAGLFLAVLRPVGRLVGAETGIPLRRPRRVVSDRPGMLDPIVDEGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMW0</accession>
    <name>A0A010YMW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine pyrophosphate-dependent enzyme, putative carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2628"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="7">
        <location>
            <begin position="41"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="5">
        <location>
            <begin position="231"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="6">
        <location>
            <begin position="432"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="589" mass="62723" checksum="075855898E2D3836" modified="2014-06-11" version="1">MSQTTTEPPAAAAGSSPETDGESGATAAILRARSGDPDRISGGHLVAKALKAEGVDVIFTLCGGHIIDIYDGCVDEGIAVVDVRHEQVAAHAADGYARVTGKPGVAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGALSQHKMGSLQDLPHVDMMTPITKFAATVPHTTRSADMVSMAFRECYAGAPGPSFLEIPRDVLDAEVDLKDCTIPEPGRYRVSTKSAGDPAAVERLADVLAHSSKPAVLLGSQVWTGRGTDAAIDFARTLDIPVFMNGSARGSLPPGDPHHFHLSRRYAFNNADVIIIVGTPFDFRMGYGRRLPAGATVVQIDMDYRTVGKNRDIDLGIVGDPGAVLAAVTAASSGRLAKPNRRAWFEELRAEESAAYQKRLPRQLSDASPIHPLRLAHEINEFLTEDSIYIGDGGDIVTFSGGVVQPKTPGHWMDPGPLGTLGVGVPFVLAAKYARPDKEVVALFGDGAFSLTGWDFETLVRFDLPFVGVVGNNSSMNQIRYGQMRKYGEARQRVGNTLGDVRYDEFARMLGGYGEEVRDPADIGPALRRARESGLPSLINVWVDPDAYAPGTMNQTMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPF1</accession>
    <name>A0A010YPF1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851614.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3162"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_0_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="24088" checksum="C21794C9D904EA96" modified="2014-06-11" version="1">MTTSRPRDRPLRTDAARNRTAIVVAAQGAFAECGLQVPFDEIARRAGVGEATVHRRFGDRASLIAAAFSDKMAGYAEAAAQALADPDPWEGFCGYVRRVCAMQSGDRGFADLLTLTFAASDPAVDELEHRRNRGFRDWVALVRRAKTAGRLRRDFHPDDLIVLLMANAGVVAATATTAPDAWRRHVEYMLQAFAADNLQPLPAPPARTALVDAMRRTQGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPG3</accession>
    <name>A0A010YPG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570321.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048587_1_1_11"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="317" mass="35366" checksum="EE7F5CFBEB97664D" modified="2014-06-11" version="1">MPSREIEFLSGGETVRGDLLLPEGEGPFPVVVMAGGWCYVKELRQPQYAADFVRRGFAALIFDYRRMGASEGTPRQHINPWDQIEDYKNAITFAAGQPELDADRIGIWGISYSGGHVLIVGAIDPRVKCVVSNVPVIDGYQTMWRMHGTDRFRKLKAFVAEDRAKRTETGEPGYMAMSGVPANPDDAFSVWPDNDVLAVFNELKATQAPRHEHRNTVESLELLMEYNAAPYAPRLLDKPVMMIVADQDDITMWDQEIGAFTAIPSSKKELVVLPATDHMTLYSNVTALDYAAKAAGSWFDRHLKELPTVANQIVKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ58</accession>
    <name>A0A010YQ58_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="42" mass="5337" checksum="458703A6209DEC1A" modified="2014-06-11" version="1">MSGCYDYSYNECNDYSYEECKPRRRRHHKKRYNDCWDYNPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQZ1</accession>
    <name>A0A010YQZ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570606.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335694_0_0_11"/>
    <dbReference type="OrthoDB" id="1671519at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="22707" checksum="452A0C683C80F9C7" modified="2014-06-11" version="1">MTGVTLVAFVRVPPDQAQQLASYENVVLGLLPTHGALVERRWQSVDGCTEAHLLSFPSREAIDAFDADPRRAAARAGIDGSGVRALRFVVEPEEGPQGIVLWRFRTDGRIGILLKRGQDIADVDLRLTADVLLSQDRYLAAAERLARTTLGDDVEPSDPEFTFYVGREWVLRFAEGGRDPFGIFVVFDDRDAVRLEDLEPGDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV65</accession>
    <name>A0A010YV65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847445.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.61"/>
    <dbReference type="HOGENOM" id="CLU_057502_2_1_11"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="243" mass="25434" checksum="505D46CBD1945912" modified="2014-06-11" version="1">MRSELFAASNMEQESAQPGLRLQNSKLLKVELRGEIFARVGSMVAYQGNVQFQAQGSGGLGKFLKQKLTGEGVPLMKAVGQGDVFLADNASDIYLIDLEGPHDGLTINGANVLAFEPTLQWDIKMVQGAGMFSAQGAFNTVFSGQGRIAVTCKGTPVVLKVDQPTYADPQAAVCWSASLQTGYHRADQLGLGTLIGRTTGEAFTMSFAGQGFVVVQPSEQPAGLGAGGGGQQQQQGGLGSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWU5</accession>
    <name>A0A010YWU5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848394.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.660"/>
    <dbReference type="HOGENOM" id="CLU_109389_1_0_11"/>
    <dbReference type="OrthoDB" id="1593638at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="14970" checksum="2C07687F368873F5" modified="2014-06-11" version="1">MSETRPDIDDAEDDGVLDPADSLDDDDLRSDVLDRGVDAGDRYRASDRFGTTAEEQARGESLDQLLAEEEPDVSAEYDDEDEDVPADLGSTTQERAGRLVEPDEGAHEDEEAEAYAVDAGVDGAGASAEEAAIHVVDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX86</accession>
    <name>A0A010YX86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit,precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit</fullName>
            <ecNumber evidence="8">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.801"/>
    <dbReference type="HOGENOM" id="CLU_031955_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="41824" checksum="967CD64301B8D9FF" modified="2014-06-11" version="1">MVTVVGIGADGWAGLGDPARDALRSAEVVFGSRRQLGLLPTDVPAERISWPRPMMPSIPSLLAANAERRIAVLASGDPMFFGVGSTLVRQLGADRVRVFSHPSSISLACARLGWPEEKIEIVSLVGRPTERLHTAIHPGRRVLALSADGTTPGAVASLLVSRGYGASTLTVLEQLGSADEARRTVRADEWDGETTAALNVIAIDCVASPDAALLPLVPGLPDEAYDHDGQLTKREIRAITLARLAPMPGQLLWDVGAGAGSIAIEWLRTDRSCRAVAIEHRPDRAARLSGNAASLGVPGLTVEVGSVPGALAGLDAPDAVFIGGAVTADGVVDACWEALKPGGRLVANAVTIESEAVLARWQASLGGDLTRVSISRAAPVGGFLGWKPMMPVTQWVVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXB3</accession>
    <name>A0A010YXB3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.838"/>
    <dbReference type="HOGENOM" id="CLU_065810_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457726" description="FMN_bind domain-containing protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="3">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15061" checksum="2E7E6F29DB6E7670" modified="2014-06-11" version="1">MRKFLYALLGTVAGLGGLIGLKANLAPAETPAQAAEQPPAAEVEQPAADAGAPAGEAKTATGNKATNQYESFQVKVTVSGQRITKVEIAGLTTKDARSKQVTGDALPKLQKATLEAQGADVDTVTGATYTTKSYKESLQSALDQAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXC8</accession>
    <name>A0A010YXC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569721.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16616" checksum="ED1FE951069C772A" modified="2014-06-11" version="1">MKYIHYVPPSVNALDLVLELTVLLGEDMTQSLARDHLTEPRAHLLWVLGAQGPSTQKSLADALNVSARNITGLVDGLEQTGYVTREPHPDDRRATLVSMTEPGAAIVSAFRSGQTELAEQLFGPMTPGELDQFVTSLTGVVERLRAAIAEGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZM0</accession>
    <name>A0A010YZM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569935.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1707"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="33155" checksum="861F88B0B1550B02" modified="2014-06-11" version="1">MTRLRRLGLWLVLATVTLLLAIASPTFRTVLNAQNVLEQTSLLGIVACGMAVMMISGGFDLSVGAVGASASVVGAIVAAHVGGPLTLVAGLLVGLALGFANGYLIAKVRINAFVATFAMSNIVSGVLFTVTDAQSHVGAPALLTTAATGRVLGVPTLFLVFVAVLAATWFVLTRTKFGHYVYSVGGNAEASHLSGVPVQRVQIFAFATGGVLAGAAGLLLLGQTQVGQPSAAQAWPLNAIAICVVGGVALTGGVGRIEDVFAATLLLGVIANGLNQLNVSPYWQPAITGLVILVAVVLDQYNRRRTPGRRAGNPAEPSRPTALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZU5</accession>
    <name>A0A010YZU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849758.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117215_2_0_11"/>
    <dbReference type="OrthoDB" id="2010785at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="14809" checksum="636C5AD4725EBBAE" modified="2014-06-11" version="1">MAGRVRGRLRVGRGRPRGERGSSPVELAILAPAVLLALFASIQVAAVFMARSVALSAAQEAATAERVAGAPAGAGEDRGQRFLSRAGDWLDAGQVDVRRDGEQVTTTVTGEAISLIPGFSFTVTETARGEVERFTTDDGGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z018</accession>
    <name>A0A010Z018_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849853.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1835"/>
    <dbReference type="HOGENOM" id="CLU_033995_0_0_11"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="23"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="42625" checksum="F5EEE438003CD406" modified="2014-06-11" version="1">MTDLAHREEAPAAAPSILRQPMAVWAVAFASVIAFMGIGLVDPILPAIARDLDATPSQTSLLFTSYMAVTGVAMLITGVVSSRIGPRWTLLSGLAVIVVFAALAGASDSIGAIVGFRAGWGLGNALFIATALATVVGAASGGVASAIILYEAALGLGIATGPLLGGVLGGISWRGPFYGVAVLMAVAFVAILALLPPIPKATRTTSVLDPFRALRHRGLLTLGLTALLYNFGFFTLLAYTPFPLGLDAHGLGLVFFGWGLCLAFTSVFVAPRLQRVFGTLPTMYVNLAALSLLLVVMGLGVSSPTTLVVCVVAAGLLLGINNTLITECVMEAAPVERGVASAAYSFVRFIGGAIAPYLATKLAEEVNAQIPFYVGALGVGLAVVVLRLGRGYLRHVDRHEPAPASAAVVTAADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z032</accession>
    <name>A0A010Z032_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849880.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1856"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="31343" checksum="97774F6F6AF1270B" modified="2014-06-11" version="1">MTRVMLLGADGFVGAHVGARLASEPEVEVTTVTRRGDVDADVRLDLAESPVAVAHTLRDAAPDVVVNCAGSTAGEASSLAANNLVAVGNLVDAVLTAGRPLRLVHLGSVAEYGRIPAGAAAREDSPERPVTPYGLTKLAATHLVRTAAAAGVDAVTLRVTTPIGPDAPVSTLAGRLVGQLRQIEAEGAGGVTTGPLDDVRDFVDIRDVAEAVVAVALRPRGRAALPSVLNVGSGVATPTRDMVSALLALAGFTGGLRTDGGGASRETALPWQHADITRAVEDLGWSPRRTLESSLHDLWHSALAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z041</accession>
    <name>A0A010Z041_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049869_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="33312" checksum="2E622B25DA8F118A" modified="2014-06-11" version="1">MILVPTAVWCVAYGLMSLAWALGAPGFPFGDGDSRGREMGSLLASAHPVPTGVALGCGALIAAATAVWAMRRPGRAPGVVLLVCAAALLAVVPDVRLLQNLAYSFSGFFGLVDRPVLNQALCVLGAGLLARSAVVLLRPAAVDAGRWLTIGRWATLVAVLAPLPYALQRAAWNLGLPLGVSQRFVDDLAADVAAKGLPAAAAWMLVIPDVVGVLLTLGLIMRWGERFPRWVPLRGGRSVPVWLAVVPASVVSAAVTIAGLVVIRFAVEGGSVSATAAPGLLWLPWGLALGVATYAYAERRRDSESSTNRTTVGAVSTNRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0Z8</accession>
    <name>A0A010Z0Z8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation and cell division SsgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850293.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2177"/>
    <dbReference type="HOGENOM" id="CLU_126599_0_1_11"/>
    <dbReference type="OrthoDB" id="1627707at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="15820" checksum="3BD42BA65C57EA4E" modified="2014-06-11" version="1">MGIAQPTRVQVDVSLRLVVPEGSSLPVKASLRYEPEDPYAVHVIFHAGSTEASGEVSWSFARQLLADGMSEPTGIGDVRVWPWQAANGPSVALALSSPDGHALFEVPRLALGDFLGRTYRQVPEGAESVHLDIDGALAALLGSYGSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z114</accession>
    <name>A0A010Z114_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2933631_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="60" mass="6317" checksum="1CBFF357389179FE" modified="2014-06-11" version="1">MDPSPSEEGIAMFTKTDETLTAVTPELLQELLVNGEGAATDDALEGGFVPICVQPPSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1J4</accession>
    <name>A0A010Z1J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850550.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_11"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="32363" checksum="8F348E1AD706CD3D" modified="2014-06-11" version="1">MLETFTLHKHQFDQYRGEIATRSGPASFVDTGGGGIPALFVHGVGTSSYLWRNVFAELVGDRRCIAIDLPLHGRTPASADQDFSLPALAEFVAHCCDALRLARVDLVANNTGGAVAQIFAVRHRERLNSLTLTNCEAHDNVPPTAFLPTVLLARAGMLARTGPPLLHDLPRARELVYGVGYQDVDALPEEIVLANLTPLIGTHEAARQFQRFLTSLRAPDLLAVEPELARLNVPTQIVWGTADIFFGRRWAYWLRDTISGASRVVEIPGGKLFFPDERAREFAATLRRHWARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2L3</accession>
    <name>A0A010Z2L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851076.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2745"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="476" mass="48860" checksum="1FAC6338A0F1BA06" modified="2014-06-11" version="1">MPSVTRKNRPHEGVPMRAWSVLLVLCGAIFLEGIDVAMLNVALPAIRADLGLSTGVLSGVVSAYVLGYGGFMLLGGRAADLLGRRRMFLSWLVVFLAFSGLGGLATEGWMLLAARFATGVAAAFLAPAGLALVTGHFPEGPQRTRALGVYAGTAAGGFSLGLVAGGLLTSIGWRWVFFAPVVLATLILIAAVPLLRDDGPRPPRAIFDLAGAVTVTTGMLLLVYGVVRLEHGLTAGTLAVFALAATALALFVAIERRAAAPLVRLAILRSPSLVRTNLVALLFLASFAGFQFMVTLYLQELRGWSPLQTGLAMLVVGIDTVLAPTLTPWLVDRFGTGRVLFGGVASAVAAYSLFLPVAPDRTYAAMLPGLLLLGLAFALSYGPLTMAATDGVDEPEHGLAGGLLYTSIQFGTALGIAGVTALSTAGGMDGIRAGLVLPVVAAAAALGVTAVGLRRTPPSAPPPGGDVPSARSSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2T9</accession>
    <name>A0A010Z2T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025182_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458055" evidence="3">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="386"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="520" mass="55102" checksum="CB5F783B911FA2A6" modified="2014-06-11" version="1">MGGVLLTVTFSLSALAGAVTAATAFRHRARVPAGTPLGVATTGITGWSVAAAINAGVGDPAWTLPLAAVGIAGHVLIVVGYLGLTEVVAGRRWRPRRPVAALLAVEPLLVVVALATGVFFDGVERAADGSWQPVFGLGYTLHFLYCYAVTLTCAYRALRYAYRRSAFTRRVAGWLALIALPPIVVNLVAVTVLHNNDVTLIGTVISAGLAYGALTRRSIEWLPIARAQLIDALADGVVVIDRDGFVADANAVGRQLIVGSAPWVDDPIGVAVDSIDPTFPLLEPEDTDFVFASGRLGLDLEIRTRVIHDRTGSFAGWVMIARDVTAHRAQHRALEAANEQLREQITTIERLRADLAEQAVRDALTGLHNRRHLMNVLADAERGHTGPLSVALIDVDHFKQVNDRYGHAAGDRVLVAVAHLLASGARPDDVLARYGGEEFVLLLPGVASDAAHTCVDRLRTLVAGTALEVAGETVRVSFSAGVACGTAPVDADALLEAADLALYAAKRNGRDRVELATSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4V9</accession>
    <name>A0A010Z4V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2842420_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="65" mass="6777" checksum="E6E03AD7587FAD10" modified="2014-06-11" version="1">MDLVHAEGHDDRVIGHRAAVGLDRLTAWVTAAPPTTTRGTDAVSAVTSPGRRPAELRIVSGPHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4W3</accession>
    <name>A0A010Z4W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852153.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3524"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="32472" checksum="75DA54124F2B9A18" modified="2014-06-11" version="1">MNLRQYEYALTVAEEGSMTAAAERLRVSQPSLSQQIGALEKHLGVRLFTRTPSGMAVTVAGRAFLAEARIATTASRRALAAARAADGDLAGELIIAVHMGLGARQLPRALGRLRQRYPKLRVTLHEEPDPTEMERLAREGTLDAILVHRIPAGCTFDTHVLGEESYVAVLPDGHPKLAGGTALSLDDLVTEGWVRFRRTSKLDDYLARLLDDTGTSPTIVASASQITTAVRLAAQGLGVTVVPASAVPEGLERLARPLLPPLTEPVLLGLRRHPGPAEKVLLDHLRQEDWRGVDVPAPPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5I0</accession>
    <name>A0A010Z5I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3765"/>
    <dbReference type="HOGENOM" id="CLU_119977_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12124">
        <property type="entry name" value="Pgbs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012102">
        <property type="entry name" value="Protoglobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protoglobin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="22051" checksum="5572DD0A47F9AE4A" modified="2014-06-11" version="1">MMTTPGYDYDDPSLRPSPVTLDDLEKLKATVLFSSADEAALKTAGDVLAPQIDQILDVWYGFVGANPHLVAYFSTPSGTPLPDYLARVRARFAHWILDTCNRPYDEQWLAYHQEIAIRHTAEKKNETDHVDSVPYIPLRYMIGFIYPITATIRPFLTAAGHREEEVEAMFNAWFKSVTMQVTLWSYPYAKSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK43</accession>
    <name>A0A010ZK43_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847412.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.47"/>
    <dbReference type="HOGENOM" id="CLU_058421_1_2_11"/>
    <dbReference type="OrthoDB" id="2084223at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="19647" checksum="6CD578523B0BA6E0" modified="2014-06-11" version="1">MTPVRFAARTLLGYTFVRGGYAALRDPGESAEAVRPLVERVANQFPSVPKDPTTVVRATAAVQILAGTALAFGRAPRLSALLLAGSLVPAGGILPHKSADASPETKARQRAEFEKNLAVLGGLVLAAVDTQGRPSISWRARRAAKSARKSTEYAAKSARKSTEHAAKSARKSTEHAAKLAREKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKE6</accession>
    <name>A0A010ZKE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569546.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136722_1_0_11"/>
    <dbReference type="OrthoDB" id="2074700at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="15101" checksum="AA368F97906E3E35" modified="2014-06-11" version="1">MKTTLWLFRLSLTVHAVCVLAQPILAGLYLDGSYDALGAHSLNGSILPATGMVVGAAALAFWIAGGAGWPLLAYATLWLAEGFQIGVGYARVLAIHLPLGVTIVVLTVWLTVWVWLPRAARRRRRRTSARNALDRLEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKK6</accession>
    <name>A0A010ZKK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847675.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.199"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="367" mass="40409" checksum="3553A3915E361815" modified="2014-06-11" version="1">MSVLLDVKDLQVYFPIKRGALFDRTVGHVHAVDGVSLSIERGETYGLVGESGCGKTTFGRGLLRLVEPTGGSALFEGEDLRELKGEALRKARRRMQMVFQDPLSSLDPRQNVESTLSEGLKAHGLWGKDGHKTLKEILDAVGLPATALRRYPHEFSGGQRQRIGIARALVLKPDLIVADEPVSALDVSVQAQVLNLLEDLQERYGLTYLLIAHDLAVVRHTSDRVGVMYLGGLVEEATSTELYEQPLHPYTRTLLSAVPVPDPLVEDSRQQILLSGDLPSPANPPSGCRFHTRCPWRQETRCDTERPEMRELAPGHRVACHWAEDIRDEKIQPHEVRPELVEASEALGSASVQTVTAEIAGTLPPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKN3</accession>
    <name>A0A010ZKN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid transport protein (AzlD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.224"/>
    <dbReference type="HOGENOM" id="CLU_159912_0_0_11"/>
    <dbReference type="OrthoDB" id="1965661at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="104" mass="10481" checksum="003D08F5E2CE06F3" modified="2014-06-11" version="1">MTGLLVAIAVLGVGTLGFRLAGPLLRERLTLSPRIESLMGRLTVVLLVALVATTATLEGGEFAGVARPAGVLVGGVLAWRRAPFVVVVIAAAGTAAGLRLLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL35</accession>
    <name>A0A010ZL35_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator with C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847936.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.373"/>
    <dbReference type="HOGENOM" id="CLU_074072_3_1_11"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14279" checksum="D694C988A3C0A921" modified="2014-06-11" version="1">MTSLKSPQDAVRSLGEFIREQRNGSQISLRQLAKQAGISNPYLSQIERGLRKPSAEILQQIAKALRISAETLYVHAGLLESPDGVRTDAAPGVTASAIDADEHLTDRQKQILLEIYHSFRRENEASAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLI3</accession>
    <name>A0A010ZLI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848260.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="1225778at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="300" mass="30971" checksum="28F61D40BBC037EA" modified="2014-06-11" version="1">MSDYAIRLGATGGPEVLRAEAVELPPPGPDEVRIRQTAIDLSHDDVLVRTGSVPAELPTGLGSSAVGVVEAAGSRADVAVGERVAYATVPFGAYATVRNVPAEALVPLPDTIGDEDAAAVLARGLLVWALIRRVHRVEAGETVVFHAAADGVGLIAGQWLSHLGARPIGTVGAADEVRLAIENGYDEIVLDRFDDLAARARELTDGVGVPVVYDPLGVSTVASSTAALGPHGLLVSSGPRLTTHLPDATALRAASAEVLDLVVRGVVRPNLRQRFDLADAGKAQEALESRALVGATVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLP3</accession>
    <name>A0A010ZLP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013384_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="843" mass="89295" checksum="B75FF059552130AF" modified="2014-06-11" version="1">MPLTLVSALRGRPEHVPPDFPDAPASGTDGPTTRTDASRLLSGRVGLGPIAARSGAVLRAAWCVVLPAVAYGGGAVAAPSVWQHVLLLGALAWGASVAAICWTGRLPTWLVLGDAVVSAGLLIATVRLLPAEFAGAAGSWVIGWAGVSVLLASWRLRASLVWLVALAEISAYLLGSQLAGAELESREPLGLARPIADTVQAAGVLLALAAIGLVLVRLVRLGALNASGTIRGRNTARRTDQVESARLHDRSVRRLLLHDTVLTTLTAIARGGLEGRADVVRARCTDDMESLAHDPRADEPVRTGRRLLDVVHRQAAHRGLRVYVAEGAPADPLPAEVTTAFAAASREALSNVEKHAGTTEVGIAARGGENWLELTIHDRGRGFDPATARTGGLGLKKSLTGRMTAVGGAASVQSAIGRGTVVTLRWSAEEAAHVGVVPPPAIEETPRAEPAVPNQVDEERILADRYTRYGLLALAWIGHFWQALSLGLLITNWANYRSGWVALGGWSVLFVITLVQVYLVTLQGKRGHPSDWIDRHAGWMTVLSVAAALAVLLDCTSAGLLTPANWPIGVLGWILSVFALRRPLWFDLAWLTIALTTLVAVAIEWSGSSTAVAIALGVVFGAGIPQVGALVIVFELRRHATVAATALAEQHQLDAARAARDAVTADRIQRDAALSRDLFPLLRALSNGSANPDSPVVRRRCELAAAEVRALVDHDDLTTPIATLDAVAAVTRSARQRDIVPVVHLGEGLDVVSPGWQRTFAQLTDRMLAEALPGEATLTVRGTPEEIAITFCFPTRTPAPLLQSVAVGVGNQLVPDRQIRVDIEPDMTNTAWLEVTWDTRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMY3</accession>
    <name>A0A010ZMY3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ORF">CryarDRAFT_1109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1090"/>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="372" mass="41603" checksum="8FA6626C2BD7C1A0" modified="2014-06-11" version="1">MAALDLHEELKALDSTMTSVEAVLDLDKLRRELAELNEAAAEPGLWDDQERAQQVTSRLSFVQGELNRVGSLRQRLDDARLLLEMAEDEGDSGSVEEVATEVESLKKTVEELEVRTLLSGDYDPREALVTIRAEAGGVDAADFAEMLLRMYLRWAERHHYSTEVYDTSYAEEAGIKSATFTVRAPYAYGTLSVEQGTHRLVRISPYDNQGRRQTSFAGVEVLPVVETTDHVEIPENDLRIDVFRSSGPGGQSVNTTDSAVRITHLPSGIVVSCQNEKSQIQNRAAAMRVLQARLLERRRQEQKAEMDALRGDGGNSWGNQMRSYVVHPYQMVKDLRTQYEAGNPQAVFDGDIDGFIEAGIRWRRQQDADVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNE9</accession>
    <name>A0A010ZNE9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849011.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="216" mass="23434" checksum="0D6DFEFF80139D0C" modified="2014-06-11" version="1">MTGPSRRLPRRVREQQMLDAATAVFSERGFHAASMDEIAERAGISKPMVYLYLGSKGELFSACIRRAGGQLTEAISAAADPGLPAEQQLWAAVQAFFGFVGEHREAWAVMFRQARGEGEFAGEVAGIRRLVVDNVADLFARAIHSAGAVDPGPDELRALAHALVGTGESMAEWLLDHPDEKPETAATRLMNMLWMGLGSLIRGEVWRSPVPVPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNM9</accession>
    <name>A0A010ZNM9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1319"/>
    <dbReference type="HOGENOM" id="CLU_041009_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="460" mass="49452" checksum="F1D21C84865181A3" modified="2014-06-11" version="1">MTKDSGALAGLLDSAGLTPDVLAGLIDIVGAGDLSELRRQLRTVGGCSRPIQLSGTVFRLDPASGVIAPSWYSTEEATGTLLVPCGSRHGVLCQACARRYAGDTWFLIYAGLAGGKGRAPSVRTHPRLFVTLTAPGFGPVHSSNVGSDGNPALCRPRRDRPICPHGLPAWCPARHPATDPLVGAPLCHGCYDWPGLVLFNAHASALWHRWRIQLGREVARLAGRTVRDVAALVRVACMRVAEMQARGAVHLHAIIRADAATDPDRAPPAWLTADLLAEAAIEAAGRVWMAAPLNRVGEWEFAWGRQVTADPIPPGNDDETERRLAAYLAKYVTKSLGVGLARRIGAPAEIPILDVPSHIRAVIGVAWRLGALPELQSLRLRAWAHQNGFRGTVAARTRTYSTTLTALHQQRRDYRAAQSDDDRFGDDVAGPTRFRYARNGLDAAGAWLAATEHDTNPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPC5</accession>
    <name>A0A010ZPC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="305"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="569" mass="60091" checksum="5C07B60082C3B375" modified="2014-06-11" version="1">MAAIAGAAYLAGGVIGLFSAVLQQDSDGDVYVLALSLVAIALGCGLGIVAVRGHRLPETCYHLLALAPIGVITLGIRAERESLLAMALASLLILVTIFAFAFFTWVAAWSLQVLSVVALIGAKLAWDAMPWMAAVAMSVQNVILAVILGWLVRAAARAETDDLTGLPDRRGFERALASALDRAARIDRPLSLAFLDLDDFAAVNEQRGRAAGDQLMHLVAQEWAALVGSDGVLARYGGDRFALLLPLSVSQASELLERFPREFSAGIAGRCLDDTPVTLSGRAEAALEEARRAGGSRVFCSADGAADNWAEMAAALSAGEFTVVYQPIVDLGSGRTTGAEALLRWVRADGAPVSPVDFIPRAERSGFIVELGRFVLETAGREAAAWAVPGKITVNVSGRELHQPGYYDQVTTTLMTTGLPPGRLVLEVTESMLEADSPVALETLRRLRALGIRIAVDDFGTGWSSLSRLDRLPADILKIDRSFVAAIAPEATSAPLVAAITALAAALGLRTVAEGVEEEHQATVLARHGVDEVQGWLHGRPGDSAAIRAALGRPAVDRPDLPVTDRVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPG3</accession>
    <name>A0A010ZPG3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139818_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="15976" checksum="49CBDAAA25EF640A" modified="2014-06-11" version="1">MPGMARKELVILTDDLDNSEIDPTVVDRPTVNFGIDGVEYEIDLGAANQTKLREILDEYVRAGRRTGGSTVRKGRKQAGSTPGASSTRAENAAIREWAEASGIDVSARGRLPKEVVERYRGHFSESESDADSAPAGRPAANSEQPAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPM1</accession>
    <name>A0A010ZPM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569931.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1684"/>
    <dbReference type="HOGENOM" id="CLU_041141_5_0_11"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="332" mass="36628" checksum="63667EC04910C65B" modified="2014-06-11" version="1">MRADRLVSLVLLLRRHGRLTAETLARELEVSTRTVLRDIEALSAAGVPVYAERGRRGGFALLPGFRTELTGLNDDEALALLVSGARPGARAFGLGSALASAMRKVVDALPEHQRGVQRLLLDPEIDLLSRRAAPEEIPGPVLAEVRSAVLTGHKLRIRYAARGAAPQWRTVDPIGLVTVRSQGYLLATRDGADRTYRLSRIDAAEELPEVAERPDHVDLDAVWRERSARFRAGGDVVTVRLRIDPARREELAGTALTVDDERTEDGGWVRLEATFQDSRHAEWALWQLSTRAEVLAPQRLRAVLHDRAAALLHFYGSVGYGSVTRSSRELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPQ5</accession>
    <name>A0A010ZPQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, SDR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849649.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1713"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29252" checksum="4D01CCC8A39F9709" modified="2014-06-11" version="1">MAGRFEGKVLFVTGAARGQGRNHAIRFAQEGADVIAVDVAHDVETVGYPGATRADLDETVRLVEALDRRIVASVVDIRDRAGLLTAVDEGVAQLGRVDVVSSNAGIATFAPAAEMSEEMWRTMIDVNLTGQFFTAQAAIPHLIRQGDGGSIVFTSSTAGLKGMANLPHYSAAKHGLVGLARSLANELAPHRIRVNTVHPTNVDTVMIQNTETRALFGGPDVSREEFAEAATPMNMLPIPWVDVDDVTEALMYLSSDAGRFLTGVSLPVDAGMSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ08</accession>
    <name>A0A010ZQ08_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847801.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151185_3_0_11"/>
    <dbReference type="OrthoDB" id="1930308at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="10918" checksum="814982AFCE28EB06" modified="2014-06-11" version="1">MPYQSDEIAVNFASLMKASEDIQGAINKLSAELDALERGVQPLVATWDGPAKAAYLVRKREWDGASADLTQLLTSIKGAVVRSAEIMSAQEAKNTSLFNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ64</accession>
    <name>A0A010ZQ64_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849876.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1852"/>
    <dbReference type="HOGENOM" id="CLU_044190_0_0_11"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="33482" checksum="2ACD2CD31E5B1A44" modified="2014-06-11" version="1">MDLDELDRQLAHALQIDGRAPFSRIAAVLGTTDRTLARRYERLRSNGVLRVVGLPHAAALGHVDWLVRMRCAPDAAMPVASALAQRADTSWVLILSGGTEINCITRTRRQQDEGELLLQKLPRTSGVAAVSAHCMLRSVAGTSGWPGRTAALDAAQVAALTPPAATGGDPVRATTADNQLLAELAKDGRASFPALAAATGWSESTVRRRLEALQHGGVLYFDVDVEPATLGFTAEAALWLTVDASALNAVGRALAEHPQIAYAAAVTGPSNIAAAVVCRDLDGLYDYLADGIGALPGVHRTETAPVVRRLKGAGTLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ93</accession>
    <name>A0A010ZQ93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">CryarDRAFT_1929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849934.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1892"/>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_11"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="34995" checksum="E17C8300DB41586F" modified="2014-06-11" version="1">MTTVQPEGRKLLRLEARNAETPIERKPPWIRVTAKMGPEYTDLKGLVKREGLHTVCEEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPKALDRDEPRRVAESVQAMGLRYSTVTGVARDDLPDGGAWLYAETVRQIHELNPGTGVELLAPDFNAVPELLGEVFASAPEVFAHNIETVPRIFKRIRPGFRYERSLDVIRQARAAGLVTKSNLILGMGEEPEEVTEALRDLHGAGCDLVTITQYLRPSPRHHPVSRWVKPEEFVAFQEQAEEIGFAGVLSGPLVRSSYRAGRLYQQAIEARATATAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRA0</accession>
    <name>A0A010ZRA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Na+-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848495.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.758"/>
    <dbReference type="HOGENOM" id="CLU_039013_1_0_11"/>
    <dbReference type="OrthoDB" id="1317830at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="36148" checksum="1BFE4B5CF3F7B73D" modified="2014-06-11" version="1">MSALRRFRPDPYIVALLSTVAFASVLPASGVVEDVLDQLIIVAIGFLFFLYGARLSTETMVAGMRHWRLHLLVLALTFVLFPVFGLALRLLPEVVLDPELAAGILFLCLLPSTVQSSIAFTSVAKGNVAAAICTASLSNVLGVVLTPLLVAMLLSSGVHVSGGTVVRIVVQLLVPFALGQLLRPWIGGFVTKHKQVLGLLDKGSILLVVYTAFSGAVVAGVWSMLSGWDLAALAISCVVLLALVLVVTWFVASRLRFSREDRITIMFTGSTKSLATGVPMATVIFAGTGAGLVILPLMLFHQLQLITCAVLARRWAAQAPAESESESAEAVPEPAAPQPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRS2</accession>
    <name>A0A010ZRS2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="18" type="ORF">CryarDRAFT_0975</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.958"/>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_11"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="259"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="393"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EXG79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="484" mass="50901" checksum="9BECF86D6198EE5E" modified="2014-06-11" version="1">MTSPARPAAVVVLAAGEGTRMKSDTPKVLHELCGRSLVGHVLAAAGRLEPAHLAVVVGYQRERVAAHVTGVNERIVTAVQDQQNGTGHAVRCALAELPDLDGPVVVLNGDTPLLTAETLQALVSTHVEAGNAATVLTASVPDPTGLGRIVRDTDGRVQRIVEHRDATAEERTIAEINSGMFAFDAKHLRAMLDRLTTDNDQGQEYLTDVLGLLVEDGHPVAAMVAPDYRETLGCNDRVELSALRALLRDRLVTVAMRAGATVIDPATVWLDVDVVLGRDVVVHPNVQLRGATVIEDRAEVGPDTTLVDTRVGAGATVVRTHSNQAEIGPEATVGPFAYLRPGSVLGRKAKVGTYVETKNATIGEGSKVPHLTYVGDATIGEHSNIGAASVFVNYDGVNKHHTTIGDHARTGSDTMFIAPVNVGDGAYTAAGSVITDDVPPGAMAVARSRQRNIEGWVERRRPGTAAADAAAAARRVASEEGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSD4</accession>
    <name>A0A010ZSD4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569804.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1177"/>
    <dbReference type="HOGENOM" id="CLU_069365_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="28583" checksum="482E0F444AB481B4" modified="2014-06-11" version="1">MVGDIRFAALGDSVTEGLGDPRPGGGWRGWAALLAEGWSSSAFVNYAASGATTARVLDEQLPSALAFRPTVASVVVGVNDVLRPGFDAAAIEARLDHVVGSLCASGAVVLTARMPDPGRMLRLPGALRRPLGRRTLELNGAVQSVAERHRTVHVDLADHPAVADRAAWHVDRLHPNERGHRVVAREFAGALSARGLPVERMPSAEPGGGRSTRPFEHVWWLATKGTGWVIDRGTDLVPHLLGMAAREFWSAVRSRRRDGGEPGYPNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSD8</accession>
    <name>A0A010ZSD8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3327022_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="38" mass="3969" checksum="E88D7A4EA0F540A1" modified="2014-06-11" version="1">MGGLKPWHVLASLCCLLILGGGVAGLIAAVTYSSRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSV7</accession>
    <name>A0A010ZSV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849106.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1331"/>
    <dbReference type="HOGENOM" id="CLU_175454_0_0_11"/>
    <dbReference type="OrthoDB" id="2024964at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="82" mass="9457" checksum="5ADCAAD6E5CB4927" modified="2014-06-11" version="1">MSSEKQIIGRVDELVAEEHSLRQRLSAGELTAAEEHERLKQVEEELDQCWDLLRQRRARRDAGQNPEDATARPVSEVEGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTU8</accession>
    <name>A0A010ZTU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851722.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3228"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="580" mass="62001" checksum="D8FFF64ADD730F3E" modified="2014-06-11" version="1">MLIRLLRSYSRPYRRHLVVLVVLQLGQVAGSLLLPTLNAAVVDNGLIKGDPGYIRRLGVVMVLVAIGQLACAAGAAYLGPTVAMSIGRDLRAAVFHRVLSYSGREVARFGAPSLIARTVNDVQQVQTLVELAAGAAVTAPIMCVGAVVLAFGQDSALALMVLGFVLVIGVVVVVSLRRLSRLHDLLQAGVDRLNRMLRDQITGVRVIRAYRRDQHELSSFERANHDLADVSLRVWRLVAVMYPVILIVTTGFTVALLWFGALRIDDGLMAPGTLTAFLGYLVLVLVSVIMATLMFLSAPRAHVCAERITEVLETHASVVAPAHPRTPAPTASRGAVLELRGVGFRYPAAARPALHGVDLCAAPGETVAVLGRTGSGKSTLLGLAPRQYDATAGAVLLDGVDVRELEPSAVAAAVGLVPQRPYLFAGTVASNLRFGNPKATADDMWRALEIAQVLAEVERLPLGLDAPVSQGGANFSGGQRQRLGIARTLLHRPRVYLFDDCFSALDNTTNEALQDALAPHLHGATVILVTQQVGRVSRADRIVMLEQGRAVGTGTHHELMRDCAPYRELALSQLTAQVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTZ5</accession>
    <name>A0A010ZTZ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849686.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1732"/>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="OrthoDB" id="1414639at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="264" mass="28690" checksum="386B185778269003" modified="2014-06-11" version="1">MDADTSAQLDTGTPHPARVYDALLGGKDNFAADRQVADAIRANPAGEIGPLANRDYLRRVVTFLAGEVGIDQFLDVGTGLPTSPNVHEVAQSVNPAARVVYVDNDPIVLVHARALLVGGTTSYVDADIRDPETILAHARVTLDFHRPVALLLLAIGHFLDDEDDAYGVVRRLVDALPPGSYLAMSHLTGEFQPEETKKTEAMYKAQGMTLRARTKDEFTRFFDGLELVEPGVTLTHRWRPDALDRVPADTPGEQAPGYGAVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTZ7</accession>
    <name>A0A010ZTZ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein, UBP type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851788.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3271"/>
    <dbReference type="HOGENOM" id="CLU_163943_1_0_11"/>
    <dbReference type="OrthoDB" id="1674309at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="89" mass="9886" checksum="7048A8E58837FDE4" modified="2014-06-11" version="1">MTAVFDPHVVMIRPVGPQTPEGCAECLELGTPWVHLRLCLTCGHVGCCDSSPMRHARAHAHAHTVGHPIVRSFEPGEVWRWCYVDEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUB7</accession>
    <name>A0A010ZUB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849859.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1840"/>
    <dbReference type="HOGENOM" id="CLU_027853_6_2_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="31841" checksum="3F2DBCF64F3F159D" modified="2014-06-11" version="1">MKLAIHYPNFSFPGGNTAIAPLLAATARAADEGGATTFTLMDHWFQMETVAPATEPMLEGYTGLGFLAGITRRIKLGLLVTGVTYRHPGLLAKTVATLDVLSEGRAMFGVGAAWYEKEHHALGVPFPPLAERFERLEETVRISRQMFSDDDGPFEGRHYRLAETLCVPRPIQQPGPPVMIGGSGEKKTLRLVAQYGDLCNLFAPDVETVAHKIEVLNQHCADVGRDPAEIEKTIITGLDALGDTDTFLRTMEQYAKIGVEQVWVGNRGVDDPPSWATEVCERVLPRLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUD3</accession>
    <name>A0A010ZUD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homoserine kinase type II (Protein kinase fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1860"/>
    <dbReference type="HOGENOM" id="CLU_677754_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="144"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="374" mass="40275" checksum="379EA9CC05302692" modified="2014-06-11" version="1">MARTFSAVVTLGSERLGEVGPFAVSPEWWAEVGPVVAGLEEVLGVPVTVLRLLDVVGGDGARDGHVRYQVEASARPAIALRPTAFPVADEPLRLPWATAAGVAELLGWASSHVRLTGRPVQHKTWNLAGLWRLPVAGGHAWLKATPPFAADEAAAIAVLASVDPDLVPGVLASAPGRVLLADVPGEDLWQATDAQVETTVRRFVAAQAAVTVRGGLRVRTSEVLAAQVEAVLGRLDLTDEERKRVRALAPRWSALDGCGLPDTFVHGDFHPGNWRGTRILDFADACWGNPVQDGLRAIDYLPPERRDTARRVWVSAWEQAAPGSRPAEALRLAEPLAHLAYAVRYQEFLDNIEPSERIYHAGDPEAVIRHALAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUJ6</accession>
    <name>A0A010ZUJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852076.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3487"/>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="180" mass="19616" checksum="7624A38D8FE087CA" modified="2014-06-11" version="1">MDDPDLPLLTAVARGDQRALEVLYERHGQALLAYAVSMLGDLAAAQEAVQDTMLACWRQASGFASRSTVRTWLFGIVRRQGLSRLRRRTEPSMDTRDLSVADSSPGPEQTALARAEVAEVRAALKHLSDEHREVLWLTFGAELPQAGIAEMLGIPVGTVKSRLHLARAALGAALPEEAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUS1</accession>
    <name>A0A010ZUS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852249.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3591"/>
    <dbReference type="HOGENOM" id="CLU_072767_0_0_11"/>
    <dbReference type="OrthoDB" id="1375644at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="2">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="34346" checksum="5A361BE16E4C74C7" modified="2014-06-11" version="1">MHIPFFGRKTARHSPPRPADDPADRHPARDDRAGHALRAPSRLHAFNRYEIKYLVPVDRLDDLRDEFHSRMDADSHGGSAGYGVWSVYYDTTDLRFYWEKIEGLRFRRKLRVRHYGDRSTIDDDTTVFVEIKQRVNRVTQKRRVALPYARARELCDDRTLVEHEPRERAFLEEVLELVNGLDLRPVAMTGYHRDAFLGRDADVGLRVTTDYRIRGRDRDFHLGADAENRLIVPARLAILEIKANERIPYWLTDLTARHNLSVARVSKYCQSVEAYGRAPRSIYHVTDEPLTKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUU6</accession>
    <name>A0A010ZUU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850127.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155914_0_0_11"/>
    <dbReference type="OrthoDB" id="2034873at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="106" mass="11659" checksum="A3E3F7EAC8C9516B" modified="2014-06-11" version="1">MTDWRSAWVDALDHLEADVAEIEELLRADQFLRETPPSDAWAPPEGIGPLPLDLRPRADRILARQLAAAEAIARAMAGNRRQAALTSKIELFDSGAARPAYLDQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV79</accession>
    <name>A0A010ZV79_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850299.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2182"/>
    <dbReference type="HOGENOM" id="CLU_025722_0_0_11"/>
    <dbReference type="OrthoDB" id="826678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025566">
        <property type="entry name" value="DUF4331"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14224">
        <property type="entry name" value="DUF4331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458422" evidence="1">
        <location>
            <begin position="36"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="465" mass="49900" checksum="AF3127570A38786D" modified="2014-06-11" version="1">MRSAQSDPYRRLLSAASLGISAMCLATLAPAPSTASSHREAPLIASTPSLDNTDLYAFVSPDASDTVTVVANWQPFEEPNGGPNFYPFAENTAHDINIDNNGDAKPDVIYRWMFRTTYRNPNTFLYNTGQVTSLGDPDLNIRQFYTLQRITPSGTKSILRTAQVAPSFTGEASMPNYGWLSNQAVTSAGADTRSFAGQSDDAFFADLRVFDLLYGGDLSKVGHDTLKGYNVNTIALQVPKSDLALKGNATRNPVVGIWTTTSRVGASMRGKPGAMQQVSRLGMPLVNEVVIPLGKKNEFNATKPTDDGKFAPYVTNPEVPKLIQALYKIPAPATPRTDLVEVFLTGVCEACGPVKANLNSQQLNKDVAKKSFVPSEQLRLNMAVPPADNPNRLGVVGGDLAGFPNGRRLADDVIDVTLQAAEGILLPNPPAAVKTLGDGVDSNNVGFRHSFPYVALPNQASVNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWP7</accession>
    <name>A0A010ZWP7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851049.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2727"/>
    <dbReference type="HOGENOM" id="CLU_914757_0_0_11"/>
    <dbReference type="OrthoDB" id="648986at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="32565" checksum="A684110A84859BF3" modified="2014-06-11" version="1">MAYDPTDLRSTLPTSSGAAPDRVSGSEHVEFRDLPPTDDSTWYARGQNFVVGYSEVDGALTFSRDGQPDEYVVLLTDDTLAATVRAGAEEVTANGRTMLVVPPGDSTVTVTGRGRVIRLLTTKSDDVAALAANAESYTRPHENIPPFEPWPEPPGGYRVRSYDLTVPPLANPAFRLYRCTTFMVNFIDPKQGPRDPAKLSPHHHDDFEQCSLVLAGEYVHHIRWPWTTNKANWREDEHRTVSAPAVTVIPPPSVHTSEAVGPGTNHLVDIFSPPRFDFSAKEGWVFNADDYPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWU8</accession>
    <name>A0A010ZWU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2778"/>
    <dbReference type="HOGENOM" id="CLU_091233_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="16366" checksum="AEBA5CC15A1D7CEB" modified="2014-06-11" version="1">MIDAIDRALLRELENDARTTNRDLAAAVGVVPSTSLLRVRALRETGVIAGYRAEIDLAAVGRPIQALISVRIRPPSRTVITAFREWAAALPETIGLFVTAGGWDFLIHVAVPDNDGLYAFVIDRLTERREVADVNTSVIFEHVRSPHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYU0</accession>
    <name>A0A010ZYU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3513"/>
    <dbReference type="HOGENOM" id="CLU_535211_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="53704" checksum="924C8C9EFBE18DFF" modified="2014-06-11" version="1">MRVGSTDVSAFARTFGAAVRRAPVGPPGVGHGVKRVVAAVVVLVLAAGGCVGSRADESLPERVNALPAGVTGLGPAVFLTPDGSRTDLPGLRAVARFGDEIAGVAPVRQHVRLAQGNPTLPTVARWPGDERRSALLSGGRVFDVTLPDSVHPDRVFPLSATVTATGTGCLTIGPDRRTNRPAGTCELARDGGAYWAEGASARFGGIDLASGAPSKAVGLPEYPTAVSSDGRYLAAKRSGSLVIADTATGAVRTTVPAFTRGVFAEGAFVAVHLVRGLRALSLISPAGTVRTLVRPVGDVSLARDGRYAVATADARLLVVDLPSGKVRPIIGGPADLGRVTATFAGDYALIAEVDEDPDLGTPSPTRVWSSDLAIAQLRAVKATPAATGVAGMDADSPAGLRFSPGGEVLTLTAGGDVTRAPSHAQPRLALTRGRMLYERNDALLVADIYGRRTELLDVGDDQRLGEIVATPDGRHVVVSLRDGAGGRASLGARDQIVLVRLDGSADPLVLYRSAVLASIGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ15</accession>
    <name>A0A010ZZ15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852259.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="145"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="25763" checksum="FC53F8D035B4B686" modified="2014-06-11" version="1">MSHRTVKDVMTTTVRIVYAGTPVKLIAEQLDFAGISAMPVLDDEADVVGVVSETDLLHKITYQDERDEWPRLLRRHRTDRAKAEGLVARDLMTAPAITIDADASVVDAARLMEKRDVKRLPVVNDTGKLLGIVSRGDLVRLFVRSDAQIRDEVEAEVFGRVLLHPPDVAAEVTDGVVTLSGTLPRRSDVELAVEFARRIDGVVRVVDALAHVDDDTSYRALREQVSYPSGPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ96</accession>
    <name>A0A010ZZ96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase, A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852412.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3699"/>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_11"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="22979" checksum="208665A76E754780" modified="2014-06-11" version="1">MTLLCASADEAVSGIADGSTVLVGGFGTAGMPFALIDALIRQGARELTVVSNNAGNADTGLAALLAAGQVRKIVCSFPRQTDSWVFDRLYRSGTIELEVAPQGNLAERMRAAGAGIGGFYTRTGVGTLLAEGKETREIDGRTYVFERPIAADVALISAHTADTLGNLVYRKTARNFAPVMATAATTTVVQVPHVVEPGALDPEAVVTPGIYVDRIVRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZE0</accession>
    <name>A0A010ZZE0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTPase, G3E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852485.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3747"/>
    <dbReference type="HOGENOM" id="CLU_017452_2_0_11"/>
    <dbReference type="OrthoDB" id="1267701at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="251"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="401" mass="43183" checksum="E300D190E12A64EA" modified="2014-06-11" version="1">MTDIPRPAVTVLSGFSPAATGAVARRLLVDDPSLLLVVHSIDDLADGTVRRLVRTAAGIVEDVTVELVHGCFSCTLRDDVLPTLVRLAHERPGSDLLLALPRAVEPEAVAAACAHSPWVAEAVRFDSYVTVVDAGRITGDLDTTDDLRDRGLHVAPDDHRAVADVVARQLEYADTILTWTPPDTDPLDRVRTATLLRRLVPWAVPVDADTGDLPAAIRRTHRHDPRLPATLGRALAGYPIGDQAPTGDWGVASLVFEARRPFHPQRLHDALEDLAGLTLRARGQLWIASQPDTVLGFEAAGGGIGLGGLGYWLAALPPARWTEASLDRRLTADATWDPYYGDRRTTLAFVGLDLASDALTTLLTHCLLTDDELADGHDTWPTLPDPFAGCFTHPETTDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZN1</accession>
    <name>A0A010ZZN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852619.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101331_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="17678" checksum="0AF3F95DBB811C27" modified="2014-06-11" version="1">MRYLVLVAAATLWVVFAVSAVSKLRGRAAYAAFVASTGRLLPSRFGAARPVALLVLAAELAVVGTLPVVPVAGLGVGAVLLGAFGVAILAATRRGVTAPCRCFGASARPLGAAQAVRNGLLAVLAAGGAAAAVAVGDPLAGAHPAGVAIALFGALVLAVLTISFDDVADLLTTGSVAVDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A029</accession>
    <name>A0A011A029_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860182_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458461" evidence="2">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="6439" checksum="F271D17776E10D03" modified="2014-06-11" version="1">MVGRRGARLVVAAGFGVLLAFGVAPGGASAAATMPPPDCGVPMPPGADPTKWCDDQHGNPNKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0E1</accession>
    <name>A0A011A0E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853054.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4137"/>
    <dbReference type="HOGENOM" id="CLU_096072_4_0_11"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="15549" checksum="CE2013B7599D60C8" modified="2014-06-11" version="1">MTPDFVAQLRTAELRVTRPRLAVLAALHDHPHVDTDSVFALVREELPTVSRQAVYDVLHALTAARLVRRIEPAGATARYESRVGDNHHHIVCRSCGTIADVDCAVGHAPCLTASDDHGFVVDEAEVVFWGVCPECSTRRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAH2</accession>
    <name>A0A011AAH2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_0030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.28"/>
    <dbReference type="HOGENOM" id="CLU_000288_135_2_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="427"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="493"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="607" mass="63175" checksum="439572EB3FC058FD" modified="2014-06-11" version="1">MTEARLFGGRYEIGHVLGYGGMAEVHMGRDHRLGRDVAIKVLRSDLARDPGFQARFRREAQNAAALNHPAIVSVYDTGEDHSSRDGVAVPYIVMEYVEGLTLKEVLTAEGRLVPQRALEIVADVCAALDFSHRHGIIHRDIKPGNVMLTPQGAVKVMDFGIARAITSASSQMTATSAVIGTAQYLSPEQARGETVDARSDVYSTGCLLYELMVGEPPFTGDNPVSVAYQHVREDPIPPSQRNPEISATIDSIVLKSMAKNPAQRYQSAGEMRADLLRAAAGRPVAAGPVPTGGERTAVLGGGAATRVVPTPGGGYSTSVGTAVGNGAEKRRGATIAVGILAVVALVAVVAFAASKLGGGGGKEVTVADVVGANQVSATRELQAQGLNVTVRTVPSTTEQKGKVTEQNPAAGEKAKEGDKVEISIGGGPGEVAVPDLKGLDEDGAKQRLEQAKLQFKPEDDEDSDLPEGRVTGQDPAPGQKLPENGTVTVRISKANRVLVPDVKGLTFDDAKSRLENAGLKARKAEAASDKAAGTVISQTPDQNTKQNRGTTVTLTVSTGPTASDSPDPDESPSEDPEPSDSAEPTESAGASASAGSTPRVGPNTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB18</accession>
    <name>A0A011AB18_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458343" evidence="7">
        <location>
            <begin position="44"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="251"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="42352" checksum="DD721F980C70CD63" modified="2014-06-11" version="1">MTTPRHRRSPTARRRNITISSVVAGAVAAALAAFMATAPTAGASDKTGTDAARPAVEAADTGPGAYTAEIRKLAVSALAAQLGISEQDAAARLDQLDKRTRTAASLQNSLGDSGAGTWISKTTGELMVGVTDQKAADAVEAAGATPKLVSRDLNDLQQVKTQLDAIGRIPGTSWAIDPSNNAVTVQVSRKAAADPRADAWLDKLAGYGDAVNVQRTTAAFATHAFFGGQAIEAEGGAGRCSSAFNATSGQNAFIITAGHCTAAIDTWTDGQEVIGQSALTQFPGNDYGVIRVDDAQALDPQPAVINQDQAQPITGTDQVPVGSPVCKTGSTTGTTCGVVLAFDTTVVYPEGAVQGLIQTDVCSQPGDSGGSLFAGDQGQGIVSGGSIGDCETPGFVSFFQPINEVLEDTGLQLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABW4</accession>
    <name>A0A011ABW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.549"/>
    <dbReference type="HOGENOM" id="CLU_025436_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="448" mass="46758" checksum="EAA1097EA65BBB52" modified="2014-06-11" version="1">MGNDGCVVADSEARKGSRRPFVTAWSRVKRARNADGADETGLHRMFDLHALSCAGDALVAVGLAGTIFFSVPVGEARVRVALYLLVTMAPFALLAPLVGPVLDRFRHGRRYALATTMLARGFLAYAIADQLDSWVLYPAAFGVLVMSKSYGVARSAAVPRLLPPRITLVEANARGSLAGTVFGALAGGIGAALAQFGAGWSLRLATVVFLVGMVLSLRLPAGVDSDKPEVLPRVFALLAHKEALRLWNLPVWAAITAGGTLRAVYGFLALFMAFRVRTDDLLLAPLAALGTVVAALACGAFVATLIGTRLKLRRPLLLDAIAVGGVAFGAMVAAVFYSLPALVLLAFATALASGLAKLAVDAVIQERLPDESRASAFAHSETMQQLAWVSGGAAGLIPVSGQWGLFLVALVVAAVTLRVSAWAWAAHRASVAPATAPANEWTATSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABY1</accession>
    <name>A0A011ABY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1955925_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459519" evidence="1">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="13161" checksum="55F4DA5CB09A2364" modified="2014-06-11" version="1">MARLVPRFVGAALATAALAGTMGCSLIGADNTEACENIQTVVKEFTSSSVKNVDDPAALGESYHKLADDIRTEGAKGDGDLEDATKDLGAAYDKLGDKVSNLANDPNPSIPDSGEVTAAGVKFKQACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC96</accession>
    <name>A0A011AC96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569692.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.695"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="23638" checksum="FE192FCAAB18C7A9" modified="2014-06-11" version="1">MTTDAAARTVRARKTYGHGDTAVTALDDVTVEFGRGRFTAIMGPSGSGKSTLMHCLAGLDPLSSGEVYLGDTALSGLSDTALTRLRRERIGFVFQAFNLLPTLTAAENIALPSALAGTTPDREWIALVTATVGLGDRLDHRPSELSGGQQQRVAVARALATRPDVVFADEPTGNLDSAAGAELLTFLRHAVDEFGQTVVMVTHDPVAAGYADSVVRLADGQVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACH8</accession>
    <name>A0A011ACH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848506.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084215_2_1_11"/>
    <dbReference type="OrthoDB" id="1923580at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="203" mass="22578" checksum="E160BE5413941F27" modified="2014-06-11" version="1">MRQPKYTLGRRAVRSLGLTRSPLRRRVDRLERTLRILSSLAVLAVSVISFLVVLGTYHRGLDEATAVRSHLRQVPVVLLSETPGGRTPVGSVPPARGPGVPATWTLPDGTMRTGNVFGAPAGALGGASVEVWMDADYAPVRPPVEPADLRFRAGATVLGCVSMFGLMIWGLYQWGRGRLDERRDADWTREWLLFERQWRDRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD11</accession>
    <name>A0A011AD11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848711.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.976"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29100" checksum="FB147D57CC6AC3A5" modified="2014-06-11" version="1">MKTRQLGADGPHVSAIGLGCLALSWTDDDDVARAVIHSALDHGITFFDTADVYGSGRNEELLGRALRGHRAEVTLASKAGLVDGGVDGSPDHIGTAIDASLYRLGSDVVDLYYLHRVDPAVPLAESWGALASLVEKGKVRHLGLSEVTPEQAAEAHAIHPVSAVQSEFSLWHRAPLETGVIEWCRANGAAFVPFAPLGRGSVNSLQPLRAVAERHRATPVQAAIAWVLAQGDHVIPVPGTTKRRYLQDNVAATRVALTADDLDDLALTGAGVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD83</accession>
    <name>A0A011AD83_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional DNA primase/polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1057"/>
    <dbReference type="HOGENOM" id="CLU_057861_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="43"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36633" checksum="FAA8D2FD244943B6" modified="2014-06-11" version="1">MSPPMQRGAPRQAPLDETSCDQATDSEHEGTARPTARQLLEQALLYAAYGWFVFVLSADKVPLRNCPRCRAGAERHDPETCTCLTCHGFYAATRDPVRIAEMIARHPDGMLAVRTGAPSGLVVVDVDPRHSGHRSLGKLEQAVGLLPGTVQQLTGGGGLHMLYRHPGHHVKSRSNAFGSDITGVDVKADGGYIVVAPSVTRDGGRYEWLGGIWSHTLPLWPAILTPLLDDRPQLRAVLNPRRRTDVRASTAHATAALRGEVERVTGSQPGQRNDELNRAAYNLGQLVGAGQLDHDQVADALRDAALSIGPDEPKILRTIRSGMNAGMANPRPHREARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADN0</accession>
    <name>A0A011ADN0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848950.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1851811_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="14970" checksum="5A25F17390C39ABE" modified="2014-06-11" version="1">MTTTGIQATRALWTDHDAEVVEPPEQAFADVFGDADRVRIALWIDRTAPAHGGLFCSDTAAGDLGLPEATVRAALGPLQHIGMVRYRNGLYMRCDHTLWSVLKVLRNFAGPTLTPSPAPAPTPDPEPHDTRAATFYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEU0</accession>
    <name>A0A011AEU0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">CryarDRAFT_1636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849487.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1606"/>
    <dbReference type="HOGENOM" id="CLU_037404_0_0_11"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="207"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="40021" checksum="6280E361EA3071AF" modified="2014-06-11" version="1">MTANPVFRLVVSGGGTGGHTYPALTAVRALQARLGGALEVLWIGSANSLESRVAEAEGIPFASVATGKVRRDRNPLKMLSGANLKDMAKVPVGANEARSLVAKFKPDVVLATGGYVAVPVGLAAKVTRRPLVVHEQTVRLGLANRVLARFAAKVALSSESSVELLPENARPIAVVTGNPVRPAVLNGEPQKAIEALGLQGFDPALPTVYITGGAQGAQQINRLVAELLPWLLTQANVLHQCGPRNVEELRARAAALPVELAAQYHVTGYLGSELPDVLALADVVVSRSGAGTVAELTALGKASVLIPYAAAAGNEQAHNAQHLADHDAAVALIGDLTSDQLRDAVAPLLADPARRRQVADNARAQGRPDAADRLVDVLLSVATAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF74</accession>
    <name>A0A011AF74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_1768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462888_0_0_11"/>
    <dbReference type="OrthoDB" id="1362354at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459566" description="acidPPc domain-containing protein" evidence="9">
        <location>
            <begin position="31"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="10">
        <location>
            <begin position="69"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG80681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="589" mass="62246" checksum="3BABC35C92C886DF" modified="2014-06-11" version="1">MPALLTFVRTLPGATFLGSVAVLLVTTALAVSGAPLGPDLAAARALSRGDGPAALVTQLGSGAVLYPVLVLVAFGRRAGGASWRSAVLPIVILAAAQTLEAVTFVTLARPGPGGGTVSFSSGHAMAAVLGWGLLAREFRRRVGYLLVAIVALVVGLSRVALEVHWLSDVVAGWAFGVLALVVSRWVVVPDVAPSPRLTSSRWAWALPAFAVSVPVVPLFTVPGDDRMKDLLVYYGAGSFAGTGSDVYEFRTVFDMPFTYPPFAALLSEPLSRVPLGLLQVLWAVASLAALVGVARIGMRPVVERIGLPVTLAVLLVSAPVRSHLRFGQVGLFLVLLVAADLLRAHRRRGGGLGVAIAVKLTPAVYGPWLLVTRQWRAFCWAVGVSVAATVAGLLLLWPSAEEYLWRALWDSDRFGANDVVGNQSVRGMLLRSGLPEVPLLWLASALVLVVIGTYGAWRLELSGNRLGAVGVLAALSVAVSPTSWVHHLVWFVLPLAALVAARRYWLSLAWAVVLTVSLPSIGASGLRAGTAHPAFWHLVIDAQGLTAVATVLFLPLLVRSRSDRELEPAVPGRGEVRRSAAVSERRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFK6</accession>
    <name>A0A011AFK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849874.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1849"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_11"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16812" checksum="8022B7DD02FA12FC" modified="2014-06-11" version="1">MPVEVGDIAPEFTLPDQNHQLVSLADFQGSRNVLVVFYPLAFSRVCSGELAAIREDLPRLQNDTVQVLTISVDSFFVHKVWAEQEGFDFPLLSDFWPHGAVAQSYGVFDEQKGTARRGTFLVDADGIVRWKVVTGIGVARSADDYAGAVAALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFL9</accession>
    <name>A0A011AFL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3116961_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="50" mass="5047" checksum="64535404B8A093E4" modified="2014-06-11" version="1">MPRSTAYAARPAVGAGSLLLRREAEVWGAVAASGGTPDHDDECGAGVAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFN2</accession>
    <name>A0A011AFN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849908.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102484_3_1_11"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="14784" checksum="E6ACCD497E09F74E" modified="2014-06-11" version="1">MDFDRPPVRASDKDRERVVELLRQHTSEGRLTIEEYEQRVETAYATKTVAELRPLLADLPVPLDEVLPAAAVVKPARAPEHSDGWVRYAMIAAAVFLMLGALVAASRGVFAVWPLLLIGIFVFGGGSGGRRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGS6</accession>
    <name>A0A011AGS6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570029.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_11"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="30886" checksum="0EFF4820F9DC4FEC" modified="2014-06-11" version="1">MYVMEAAVDETSVAGARIRYRDTGAGPPVVFVHGLFVNGELWRAVAPAVAAAGFRCVVPDWPLGGHTAPVPAADLSPPGVAALIGAFLERLDLREVTLVASDTGGAYTQLLLAGGGANDRIARVVFTPSDALEVFPPAIFGLLPVYARSRAATWLLTRLLGVRAVRNSPIAFGRLARRRFPDDVAAGYFGPARESAAIRADLRRALRHVHRRHTLAAAPALANFPGPVLLAWAADDRLFPLELGRRLAALFGHARLVAIPDTYTLVPEDQPEPLARLIVEFATAHAAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHU9</accession>
    <name>A0A011AHU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725709.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2669"/>
    <dbReference type="HOGENOM" id="CLU_114905_0_0_11"/>
    <dbReference type="OrthoDB" id="1546927at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="206" mass="22274" checksum="07BD3764E3CB2B62" modified="2014-06-11" version="1">MQLKKWAGPGVVLIATIAQLVVASVASDLPQFAGKGFGARLVLYPLMMLVVPVWWWTVKRGTRPPIAGFTLTMTPFLIDVTGNTLDLYDSISWWDDANHFVNWFLLCLGLALVLDVPSLRPAWARAIVVVGGGALLALLWELGEWYAFIRHGTELDTAYEDTLGDMTLGTCGAVLALVVTVVIGRRRSSASARSADTSPGFASLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI11</accession>
    <name>A0A011AI11_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
            <ecNumber evidence="2">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2726"/>
    <dbReference type="HOGENOM" id="CLU_059964_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="36"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="275" mass="29225" checksum="3C98045155735224" modified="2014-06-11" version="1">MTMLHFCDLKTLVGSVMLRTGFAQRLARADRCLYGTWLKTPALEPVEILADAGFDFLVIDQEHAPLTLEFAYAATVAAQGAGMSVLVRVPDRSGSHLQRLLDTGVDGILVPRVTSVAEADAAVRQMTFSPAGERGIGITSRAGRWGGLPRAEYLRFGDEEVLRAVQLEERAAIEAVDEILDVAGLNGVFLGMGDLQLSSGLPESDPVLQELVDRLLAAAHRRGVPAGTAVATAAQASAAADRGYRFVMVSNDTSLLRTAATSVVRQLEEGASHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AI59</accession>
    <name>A0A011AI59_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2763"/>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="29026" checksum="B9698A3AB4055900" modified="2014-06-11" version="1">MEETGHIDTSRPHVARMYDYYLGGKDNFQVDRDAVAAVEVAMPEVRQLALENRAFLRRAVRFMAQTGIRQFIDIGAGLPTVGNTHEIAQRAAPDAHVVYVDKDPIVLAHGRALLATDDRTTVVTADLREPRKVIEHPDVRELIDFDRPVGVMLIAMTHFLRTDEFDPVIGALRDALAPGSHLAATHVTVDNHPPEAVDGVEAAYRATPTPIYFRREDEIAAVFAGFELVEPGLVTIDKWRPDPVDPAPEPTHWLIGGVGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIC5</accession>
    <name>A0A011AIC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase,'ATPase, histidine kinase/DNA gyrase B/HSP90-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2817"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="388" mass="40295" checksum="9DC4C3FABB86D9DA" modified="2014-06-11" version="1">MTRTGDAVAAAGGHTGAVFRARVDVALAVGLAVVSAVLTAVVPAEPPFRAPGVLGVALAAVSALALVARRTAPETVVAVTSALLVVYVLAGFDVGVVQWPPWIALYTCFAAGGRRPRLVGAIACVAAVSGYAVFTRGPGDASALADVAIIGLLAAVAGEATRNRRVAVAASRSRELAEGRERALALDRMRLDERTRLAGELHDALGHAVNVIVLQAGVARRVFAERPEFARDALGTIETTGREALGELDQVLRVLHPDDAAETEPLGPRGIDGVDELAERVRAVGREVTVEIEPVELGPGAGRALYRIVQEALTNAVRHTESGRIRVSVTPDGEHVRVLVFNEATGLARPQPGRGLVGMRERARLAGGTLEAGPVDGGFQVLATLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIK3</accession>
    <name>A0A011AIK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093209_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="1">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="135" mass="15209" checksum="D1A9DD322CC56362" modified="2014-06-11" version="1">MIGVEPRALIGEWTMARRVVDRSAGTYGTVAGALVVTAFESGVRFAESGVLRWQGAELPVYRVSLLQPLDGEWWMLFEDGRPFHPWRPGTPVVHPCGRDTYDGVVALDRGGHRLRTLWDVHGPAKRQRLVTRFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIS8</accession>
    <name>A0A011AIS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851405.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382112_0_0_11"/>
    <dbReference type="OrthoDB" id="1950803at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="20678" checksum="7846C897A2FD71D1" modified="2014-06-11" version="1">MVQKLAIAATAVVALVALVTGMVALERSGDARRIAGVAADREPLPVPTVVAQQSIVPGPSVASLTPAPGRSRDRYPVAYENQHLRLQNACVGSGQAVDLDEPRVAPPDGAELTFFACTETRFAFEGPATFAEVTDPQANATACLDALRTNPGVESLRVARGQTVCVLTSGPAPRIVRMRTDSVTDRVALSVTAWTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ71</accession>
    <name>A0A011AJ71_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase,'ATPase, histidine kinase/DNA gyrase B/HSP90-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3170"/>
    <dbReference type="HOGENOM" id="CLU_021898_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="538"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="628" mass="66768" checksum="7A4124B23F4A4080" modified="2014-06-11" version="1">MPRIGPASFLGLNVVMSVVALLLSIGREEISDLIAYPLNAVALGLAGALVVGYQRSNPIGWVLSGMGFVAVFAEVTEGYGYHAAWPAAATLEWLANWTNQLGIVCTALVVLLFPTGRGLSRARRAGVWAGAIGLVLSAFGAAFSHASDQLFESAVNPHAIEGLEPVFVVGQGLFLVSLLGAIGSVILRFRRSTGVEHQQLKWVAYSLSLFAVVGPLAIIYFNDSALVRFAIALVVPTLPAAICIAILRYRLYDIDLIVSRTLAYGALTTLLAVAYLGMVWVLGAVAGGRSSWTTAGATAAVALAFRPLRGRLQGLVDRRFRRARYEALARVDTYLDDLRAGRAEPEALEALLRDVLEQPSIELRYLPPGATERAVNDDEFLVERAGVPVAIVAGGSGPLLREVVARAGLAIEIVRLRAEVTLRLAEVEASRARIVAAGYEERRRLERDLHDGAQQRLVSIGLALRNAQFALGDQAPVVRIIDAVVDELGVAIDELRELANGIRPAYLDDGLAVALRDLAERTPLPVEVHTTGERYPADVEATAYFVACEALANAVKHADAIGVTLSAEHADGELVMTIRDDGVGGARPADGTGLRGLHDRVAAQGGRMRVDSEPGAGTTVVAELPCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJR6</accession>
    <name>A0A011AJR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of various ABC-type transport systems with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3350"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="273"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="305"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="528" mass="56530" checksum="5640406C9A9A271B" modified="2014-06-11" version="1">MTLLQIRDLAVSYQTRSGPIQAVTGVDLDVEPGETVALVGESGSGKSTTAHAVIRLLSGNGQIERGSVVFDGQELTGLSEREMRAIRGARIGLVPQDPTVSLNPVKRIGEQVAEVLRLHGLTRGRAAALDAIELLERAGLPDPALRAKQYPHELSGGMRQRALIAVALAARPALLIADEPTSALDVTMQRLILDHLQHLSEEQNTAILLVTHDLGVAADRAERIAVMSQGTIVEAGPTGAVLAGPTHDYTRHLLASVPARVAGPPPVREDPLVVVEGLSKDFKDTRVVDEVSFTIHRHETLALVGESGSGKTTTARMVLRQIEPSDGAISFGGTDVTRAKGRALRALRRRAQLIYQNPYASLDPRFSIAEVIVEPLRAFGIGNPAQRLERARELLDQVRLPSSTLRRRPAELSGGQRQRVAIARALALSPELVVCDEPVSALDVSVQAQVLQLLTDLQADTGVAYLFISHDLGVVRQIAHRVAVMRAGRIVETGRTDALFTDPGHEYTRELLAAIPGGPAGSGVGARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL55</accession>
    <name>A0A011AL55_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210195_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015682496" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="57" mass="6048" checksum="775213972268050D" modified="2014-06-11" version="1">MTRLADRLLSLIAPSTTASAAMQTQCFSCSTTRAKLCRRDCIQGVCEPWGCGSCGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG40</accession>
    <name>A0A010YG40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847696.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_1_0_11"/>
    <dbReference type="OrthoDB" id="1635544at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="12984" checksum="7D005AE5C2C4E29A" modified="2014-06-11" version="1">MSTEYVDQSGPLVRPYAMTGGRTRSRVDIAMEALVTATARGDREAGSARHEWQRIVELCQQVQSLAEIAAYLGTPLGVARVIVGDMAEAGMLDVHEPGRLDDQLGTYLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH48</accession>
    <name>A0A010YH48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725650.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.627"/>
    <dbReference type="HOGENOM" id="CLU_004665_1_3_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1053" mass="112769" checksum="ED88E9095BF9F599" modified="2014-06-11" version="1">MRFRILGPIQVETADGRTVPVGGSRLRAALAVLLTEAGRIVPAQRLIDGVYGDAPPAGATNALQSQVSRLRQLLGGAAVVEFHPAGYRLAVDPDHVDAHRFRRLVAEAARVADPVALLDEALGLWRGPALADAGDTTLIRAAAAELDDARLSALDARIAARLELGHASDDLVAEVRALVAEHPLRESFRVHLMRALHTTGHSAAALLAFEDARRTLADELGVDPSAELREAHLALLRRPEPRAQAPRRLPAQLTSFVGREHELARLADLLGTQRLVTLTGPGGAGKTRLAIEAAERHPAESHLVELATVTTGAEIEQVVLDALGLRDSGLRPASPAANPLDRLVAALADRPALLIVDNCEHLIDAAATLVDHLLRRCPSLRALATSREPLGITGEHLLPVRALGLPADGDPPERIRGAPAVRLFAERASAALPGFSVDATNAPDVLRICRTLDGQPLALELAAARLRSLALGEVASRLDDRFRLLNRGERTAPARHRTLRAAIEWSWELLADDERTLARRLTVFVGGATLEAIDQVCGPTDADSLSGLVDKSLVEFADGRYRMLDTIRVFGEERLAESGELKRLRRAHAEYFLELALTGDAALRTADQLRWAAVLDRERENLHSAARWSGTADPASGLRLTAALAMYSWIRGRRSEFAALARDLLESVGPRPPHGLEEEHAICVLSARLGGHDGNWSSGGAAWSANPNELYRPPRLPFLNALTALSAGPPADSEYTKLENWYRASELDPWTAALQQFGLAYMRAMNSGDLAGAVVSLEASMAGFRAIGERWGETMALTELADLAEARGEQDRFLALNEQAMRLAVELESDEDRGGLFCRRATNAARFGDLDTADALYRHAAELGGRAGASDVQARALAGHAHVRWLRGDVEGARRRYEQGLTELTGAGYLTNEIRALLTIGLGWVAYATGDPALARERHRSALVSGVQSYSPVAGDVAEGLAAAALAEGDPTTAATLLGLVPALRGGLVASFPGLPPTADAAREALGPSAYDQAYGLGAALSRDEATELLRRPPSELPEGVRRGGTCRQGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH73</accession>
    <name>A0A010YH73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074345_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458796" evidence="2">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32847" checksum="4B641929C8A17D36" modified="2014-06-11" version="1">MRTRLVAVAVAALALLTPAACSAGTADSPKPASPSASSAPVAPAAGATSPSGCDDSAGWGCEWAPRLAAAGAIAADAPGELGVVVLDRRTGDRWQAGDVDTLFWTGSTIKLGLVATALEQSRTGVRELSDTDTQRIGDILAFSSDDAADALWREYGRSALLTRFKSRYGMSHATYVNGFDKYWGFVKCTPGDLVTLMDYMLDKLGPADRDLVVTGMRQTDDIQHWGIWSAGPDVDPGNKNGWSVEKDDGREHWLTSSVGFAGDDERYVIAEMYSMPPGQDSLERGARTLSDLSATLFGRATPAPAVIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHT4</accession>
    <name>A0A010YHT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569723.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1358101_0_0_11"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="19057" checksum="E1D75C99461D7518" modified="2014-06-11" version="1">MKTWLTWVVLAVTAVTTALGYAVPAFSDALARDPAFFDGQYWRLVTPILVNPEGWGQIITNGIGLVVFGSIAERVFGRRAWLALYLTGGVVGEIYSYALEYYSAGSSVAVAGLLGGWAAWLLSGAAKLPLPARVGAGVVPVLGAFLAATGDNHGAPLLAGTVLGGVLAWRYPLPPAQSLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHX7</accession>
    <name>A0A010YHX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848661.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2698421_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="73" mass="7205" checksum="F60166DA5AF66A88" modified="2014-06-11" version="1">MLAVLRAGQHVDVLVHSNGGRADVVASDLAVLCGVGNDGEPDGLLYLAASAAQATVLAAIGPGARLSVTVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIH9</accession>
    <name>A0A010YIH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1106"/>
    <dbReference type="HOGENOM" id="CLU_044949_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="384" mass="41578" checksum="0A55C56D0F644160" modified="2014-06-11" version="1">MEIDTPWQRLPPDLATALRPRFDETVREIADAVTAASPAFRGISDPKFPRDVKTAVTVALGRFLDLAGTGSPALPPETRAVFVGLGAAEAREERGPDVLLAAFRTAARLMMRACGEALARLRPVSAAELIDLSDAITAFVDELSAGSTEGYSRQLREQAGEGDRLRRQFAELLLRGGAAESVVHGAAARIGWAGSPSIVPVLLPLDSAREARFRFGASGIVVERDRDALLLLRSGSRAALADALAGRHAVVGPSLAWERVPEAVHLTELTAELLERRPEPTFVEDHLATLALRGEPGALAVLRAQRLAPLDQLRPPQRERLLTTLQSWLRHWGARSEVAAELFVHPQTVSYRLKLLRELLGESLDDPGTRFELLLVLAAGVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIU8</accession>
    <name>A0A010YIU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)H-dependent nitrite reductase, small subunit</fullName>
            <ecNumber evidence="6">1.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848957.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1212"/>
    <dbReference type="HOGENOM" id="CLU_055690_3_0_11"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="12731" checksum="A444DAFFF5EE1D2F" modified="2014-06-11" version="1">MTASLIAVDWQVACRVSDLLPERGACALFDGAQIALFRLWDDQVYAVGNRDPYTGAHVMARGLVGTRAGRRTVASPLHKQVYDLVTGECLSDPAVPALPTWPVRVRDGVVEVELQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ68</accession>
    <name>A0A010YJ68_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_1311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1289"/>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="134" mass="13207" checksum="14FCE542EE55442D" modified="2014-06-11" version="1">MLAACSSYGDDGSDTEATTASTPATTETTTGTTADATPAGTELGPTSDVPVGGGKIFPTEKVVVTQPTAGTFQGFSAVCTHQGCTVSSVKSGEIICNCHQSHFSAADGSVVSGPAKTALPSKTVTVSGDAIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKX3</accession>
    <name>A0A010YKX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850006.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2492617_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="86" mass="8880" checksum="A9C5ADA9408BD04C" modified="2014-06-11" version="1">MTTPPPGPLVDEAVRFAEALLHRVRGDGAPDLPPELVARFSGAVADVAVAGAGLLQVVAEVAREWGASAGAEEPDEEPPVERIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL54</accession>
    <name>A0A010YL54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_2060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850099.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2025"/>
    <dbReference type="HOGENOM" id="CLU_052646_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="11">
        <location>
            <begin position="244"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="34274" checksum="C3937FD275EBF214" modified="2014-06-11" version="1">MTSSSAPAGAPRTAGRLSRRSKGAGPQPYDFRRPTKLSREHARTLQMTYETFARQYTTLLTSSLRAISQVSLVSIEQLSYDEYIAQIGNPTLLTMVTLSPLPGITLLEIPVDMALACIDHLLGGPGGAQPQRELSEIETVLFRGLLDRILGEFRYSFDTVKKIEPKAGAIEYNPQFAQAAAPSDPMVVVSLEMKVGSQECIATMCLPFAAVMQALQKADEATALTPAERMAKDLALRNLTGGLLGAKLPVVVRFGTTQMYPEQIVALEPGDVVSLGHPVNRPLTVSTNGITLAHAVPGNHGARLACLVVDPPREDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMP4</accession>
    <name>A0A010YMP4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850830.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2573"/>
    <dbReference type="HOGENOM" id="CLU_053002_0_0_11"/>
    <dbReference type="OrthoDB" id="1273626at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="25715" checksum="200FFED44B76A8BF" modified="2014-06-11" version="1">MRIQVVNPNTTETMTATMGACARAVAAVGTTVEAVTSPMGPASIESHYDEALAVPGLLRVVAAGERDGVDGYVVGCFGDPGVDAARELARGPVIGIAEAAMRTAVLLGRTFSVVTTLSRTAGRAWELAARFGLAAQCRQVRACEIPVLDLERPGSNAEHRITEECRRAVAEDDADVVVLGCAGMADLCARISAAVGVPVVDGVAAATKMVESLVALGLTTSTRLEFARPPTKPYTGLLSSFSLETGATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNI1</accession>
    <name>A0A010YNI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2806"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="273" mass="29152" checksum="2D605F4165D22121" modified="2014-06-11" version="1">MAVIEVSELRKTYGGHPAVDGIDLRVECGEVFGLLGPNGAGKTTTVEILEGHRRRDGGAVRVLGEDPGTAGRRWRARLGIVLQSATDAPELTVREIVRHVAGYYPAPHDPDDVIARCGLDAKAGAKLRTLSGGQRRRVDVALGIVGAPELLFLDEPTTGFDPEARRSFWELIRALAGDGTTIVLTSHYLDEVEALADRIAVLAGGRIVAAGTPADLGGRDGRATVTWRDADGRHSVATDDPAGLLATLDDPTDLRVERRSLEDVYLDLIGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNL9</accession>
    <name>A0A010YNL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851174.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813092_0_0_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="206"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="341" mass="35318" checksum="4AE8D8B511EE3A40" modified="2014-06-11" version="1">MRVQRPGRALRDQALERERAVAEGAARLAASGDRDVVQSTAVETAAAIAGSAGAKGVRVMLGIGHDLRHEIVATAGERTASAIGRVVDFDELPEHLVAALRRGEAIYLERPESDLAPRRGGVLVIRLRAGGRDVGVLSVSANAPLTPAVRAALCSWTSQVAASLAGLALTEELLHRAYHDPLTGLANRELLRQRLEAALHGGPAEGFTAFLLLDLDRFDQITEALGARAGDDVLCAVADRLRGMVGPGDLAVRLDVAEFGLVLGGVRDADAATAVAERLISALRAPITADGHPVTIGGSIGVALRAPGTGASIDEIVGDADAAMNRAREAAGPVRRLSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ05</accession>
    <name>A0A010YQ05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3342747_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="37" mass="4170" checksum="FB3C264B33F26692" modified="2014-06-11" version="1">MRWLAQQHKAILVIRLFMVAVFVMCGSVKLAGGQFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ97</accession>
    <name>A0A010YQ97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852097.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624376_0_0_11"/>
    <dbReference type="OrthoDB" id="2189473at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17673" checksum="9366BCA786089CB8" modified="2014-06-11" version="1">MSAYGPAVFLSRRDGVEPTDNERQRVLSLVMEAAARLRLTDENGEPARPRPYGDPLGVLLYSGYIHGQMPTPIQRDQGEIRTTQGQRVAAEVEKAAPGVYTFEAGRGLPAGALLRRARVDARRFGLVASSEPECRRRRACRRWAVGGVVAVDGEGGVVGWTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR39</accession>
    <name>A0A010YR39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852595.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3827"/>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="OrthoDB" id="1186918at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="29190" checksum="B6895EDA37B900B3" modified="2014-06-11" version="1">MPLDGKLPDIDTSVAHPARRYNYWLGGKDNFAADRESGDAIAAAFPGMVIAARENRKFLRRAVRFLAADAGLRQFLDVGTGIPTTPNLHEVAQDVDPSARVVYVDNDPIVLAHANALLTGTDQGVTTYVDADVRDPARILAEARETLDFDRPIGLTLLAIMHFVPDADGAHTHVAELVDALPPGSYLALTHATGDFIPPEVVAEMAKRDARSKSPVVDRDRAAFARFFDGLELVEPGIVTVARWREDTEDGDRPADETVSLYGAVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YS29</accession>
    <name>A0A010YS29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4200"/>
    <dbReference type="HOGENOM" id="CLU_2329012_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG83020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="98" mass="10411" checksum="D5CC1181F73C39A9" modified="2014-06-11" version="1">MLVRATARGVSLDSPRDFTTLSLVLEGGPAAEEAAGRVGTWAGPDHLVLPASTLVELAGPVADETGWREGFDRMITLATNKGWVDSSGGVRIHVEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YV86</accession>
    <name>A0A010YV86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847495.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2154172_0_0_11"/>
    <dbReference type="OrthoDB" id="1859935at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="111" mass="12121" checksum="9E11806DE2246266" modified="2014-06-11" version="1">MDASDPHIHVTAELGTETETRNLLSSTFGLVADRPRDVRTGCGRRVAFAMTAQQPEHVTCLPCREYAAAKHLKTAEQLLETAALQGLALDPTDLRRAADHHRTLALRYGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVE1</accession>
    <name>A0A010YVE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2368133_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457966" evidence="1">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="95" mass="8904" checksum="DF2615F3AA6C45E4" modified="2014-06-11" version="1">MARKILTDEGSRRALGIVRVGSTVPPASVRAVAVTGVSAAVGVSAAAGVSTAAGASGAAGASGAAGVSGAAGGAGFVRVEAPDWVVSWTRVGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVH9</accession>
    <name>A0A010YVH9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784626_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="353" mass="37990" checksum="6903D055CA60CBE3" modified="2014-06-11" version="1">MLVASRQSSALLLQQFFGTYLNSWLRTATKGRVTAPPVVITAPAGAFAVGDLPEAKLIHFDESPAALKPLLAADLDARRGTVVGALPELLTEAEQAALLLILDVTSGTLPLADLTALLSGPRAGRWPSSDVIAFIRADAIKRAAANLVGNGRSQTALDKLDRAFGPEWRTEFHSGGPGAAVRGYLRRLEAALPGRAWPAAVRVNPNDEPVFWLILITKQPHGAWAFADAVARARRGWRRTLRQAGAAKSPKAQLVVEGLQSAERLAVGAEQHEERAVVESLKKNLLATRRRVGEFRISDRPREVLDGLFGTADTAQIRAAVRELHAAGKTLSTGVGGDIRDHVLRLPDKRAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWN7</accession>
    <name>A0A010YWN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.596"/>
    <dbReference type="HOGENOM" id="CLU_094182_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="246" mass="26996" checksum="56690B70B2CA7533" modified="2014-06-11" version="1">MPKEHESGTARTEPLPELPQDTPKDAPLDVERRGDRRSRIFGLILLAVIVLVGVGTFRACSWWNSDDRPLAESTVDRSGPVVLKSIQDLARFQAATGTFQVVVDLEKDTKYVPSSILGQRTLFVGVGTVDAYVDFAGITSDALVISEDRRSVSLRLPPPALEKVNLDQDKSYVFAQERGVIDRFKSLFDDDPNKLGDVYKAAEKKIGDAAKETDLSKRAQTNTQAMLEGLFKSLGFTSVTVTFSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWQ3</accession>
    <name>A0A010YWQ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1746573_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="16037" checksum="45942C390A391A62" modified="2014-06-11" version="1">MGSGRILEASVSPGRYLVNIVLAVAFLFIAASGVRAADDPVVFGVEYFAEGGSHQTYLVARRGGVVAGEAWLNADEYDGRRVRALSVCDRRSDGVRVGARILVPDGRALDYFAPVGKRCFGRDFGYRISRWQLLFGSASSGEVVPPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYE8</accession>
    <name>A0A010YYE8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849045.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1278"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="23932" checksum="06543E8F9ED06F93" modified="2014-06-11" version="1">MSDSVRLVIVDDQAMVRQGFAALLDAQPDFTVVGQAADGAEAVSLTRRVRPDVVLMDVRMPVMDGLEATHRILRADDTPRVLMLTTFDLDDYVYAALRAGASGFLLKDAPMADLVQAVRVVTAGEALLAPSVTRRLIADFARRPATHRARPERLRVLTPRETEVLVLIARGLSNGEISATLVVAEQTVKTHVGRILAKLDLRDRAQAVVLAYETGLVAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYP1</accession>
    <name>A0A010YYP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849174.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1378"/>
    <dbReference type="HOGENOM" id="CLU_103526_3_1_11"/>
    <dbReference type="OrthoDB" id="1697277at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="138" mass="16138" checksum="37566B9E7FFAB599" modified="2014-06-11" version="1">MTQPSPDFYEAVGGDDTFHRLVAAFYRGVAEDQVLRPLYPEEDLGPAEERFRLFLMQYWGGPRTYSDQRGHPRLRMRHAPFRVGVAERDAWLNRMRDAMDEIALPAEYDATIWEYFVRAADFMVNHIEDIQQGRAAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZT8</accession>
    <name>A0A010YZT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982520_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="31658" checksum="75F847A438DD4EDE" modified="2014-06-11" version="1">MRGRLVWGRWLRGSRRRPHHPCRLRHPRHRCRPRHPCHRCRPRYLCRPRHLYRLRRPRRRRGLRQRGCLRVRCARRCRRCLAVRPKPFGWTATPPRAVRRKQPTRKSRRRMRARCPARSHHTPMGCAGMGCAAMRPAGMGCAAMGRARMGRTGMGRTGMGRTGMGRTGMGRTGMGRTGMGRTGMGRTGMGRAGMGRGGIGSAGAGRGWVERWRPGPLESRRVRLTSEAVTGVEGDRGSEARRPLGARRGWGAGRGWGAGRGSGVGRGSEAGRGSPRWCSCRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZW1</accession>
    <name>A0A010YZW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849772.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1790"/>
    <dbReference type="HOGENOM" id="CLU_005126_4_0_11"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="16"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="417" mass="42989" checksum="E9EF33303AFA47F9" modified="2014-06-11" version="1">MHIGEILLALGGAFLAAGILARLGAKIGLPTIPLFILAGVLLGPHTPGLALVSDPSYFELLSKLGLVFLLFYLGLEFHLDDLINGGRRLVAAGIGYLVLNIGGGLAFGFALGWGTREAFVLAGVVGISSSAIVSKLLIELGRLRNPESRLILGIIVVEDVFLAFYLAALQPVLGDAASLGAAFVEFGIAFVFLVVLFGLARWGSRLVSRLLDVRADELLVVMFVGLAVVVAGAAEELGVSDAIGAFMIGLVIGSTPHAERVTTLVHPLRDAFAAIFFFTFGLTIDPGDVVSVAGPIAIAVVLTIVLNAIAGLGAARLYGFDRRAGTNVAVTVLTRGEFSIVLGTLAIGAGLDARVAAFAAGYVLVLAIIGPLAVVRTEWLSRLVPVRVLPAAEGPAPDDRAGADPTAAAEDAASASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z007</accession>
    <name>A0A010Z007_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849831.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1820"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28225" checksum="38B3DED776A87C1E" modified="2014-06-11" version="1">MKGWGWTAGGVLILAVVLFPIYWMVNVSLQPSSGAAFTPWVPVELDFSGYTKAFRDQGGHLMTSLIISVGSVVLSLLIATPAAYALAHFRVRGAGVVLLGVLLSQMVPGIVVANALYTAYNDLGLLNSYLGLILADSTAGIPFAMLILRAFMGALPREVIEAAWVDGAGPVRTFRSIVLPMSRNALVTGALFTFLFTWGDFLFALTLTTTEDVRPVTLGLYTYVGSFVKDWSSVMATAVLASIPAVVLLVVAQRYVAAGTTAGSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0I8</accession>
    <name>A0A010Z0I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850105.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2028"/>
    <dbReference type="HOGENOM" id="CLU_079895_0_0_11"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="101"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="26835" checksum="1BEBC75D627B775E" modified="2014-06-11" version="1">MDPASIIGIVVAFAIVFTTIILEGGHIGSIFLPAPLLLVFGGAICASMTGATMQDTIAFGKNFIGALTAKKIDAGASVDTIVKLAERARKEGLLALEDAIKEVNDPFLKDGLQLAVDGTDPEELREILEGQIEAKKKRDKAAAKFFTDLGSYAPTIGIIGTTTGLIHALENLAEPEKLGHVIAAAFVATLWGLMSSNLMWLPIASRVKRVSELEVDQMNLSIEGIMAIQAGANPRLVAQKLKALLPNPAPAKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1E6</accession>
    <name>A0A010Z1E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850491.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2311"/>
    <dbReference type="HOGENOM" id="CLU_060077_5_2_11"/>
    <dbReference type="OrthoDB" id="1677723at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13876" checksum="DAA18C4E57CC3FB2" modified="2014-06-11" version="1">MTKMDIAEVAASTGLTASALRFYERQGLIESSGRNGLRRTFDPGVLDRITFIGCARAAGFTLAQIGRFLVATPGDDELRARMAEKARELEQDIDRLTRMRDSLRHAATCTHAPLVECPEFKSRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z256</accession>
    <name>A0A010Z256_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850848.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="300" mass="30275" checksum="5EE1394EF50A2D71" modified="2014-06-11" version="1">MKAVRYAKYGAPSVLEVMDVEPPEPAAGQALVRVAATTFNPVDAVIRSGAMRRAFPLTLPCTPGMEVAGTVVSGGRFAPGDAVIGLLSMMEDGASAEYAVVDEAVLAAAPSGVPLADAAGFPVGALTAWQGLFEHAGVRAGQGVLVNGAGGTVGGYAVQLAARAGAHVIASASPRSAPRAHRYGAAQVVDHTAGPVADALTEPVDVVFDVVPRSDAALVAAVAPGGVYVTASTEPPPDAPVRATRMFVRADAERLAALVALLDAGELELDVAERLPLSDLASVHERAEAGRLAGKVVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2Q1</accession>
    <name>A0A010Z2Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121942_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018988">
        <property type="entry name" value="DUF2000"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017021">
        <property type="entry name" value="UCP033763"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09391">
        <property type="entry name" value="DUF2000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033736">
        <property type="entry name" value="UCP033763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="154" mass="16299" checksum="93A5A2E8B588981F" modified="2014-06-11" version="1">MTITDEASTGELLALTTRQQRTKWVVVVDRDLPIGLIANAAACLSATIGQQRPDLLGPATADGSGLEHQPLPFIGCSILGADAATVHRVRTRAASRPALLVVDMPQVAQQATAYAEYQATMAATPHEELAYYAVGLVGPRNQIDKVVGGLQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z353</accession>
    <name>A0A010Z353_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2924"/>
    <dbReference type="HOGENOM" id="CLU_153937_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045778">
        <property type="entry name" value="DUF6204"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19707">
        <property type="entry name" value="DUF6204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="12921" checksum="4570C5DA18552B1A" modified="2014-06-11" version="1">MVSTRTFRITVRGVFDGLDAEQRAALQARAAEHDVFTAAFTPEGTLTYDVAARPAFTFRFSDTGDDEEDILVATELAEEKAAAWLTERGYGYKNLRSTAEDLSMAPLGKRGRREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4N1</accession>
    <name>A0A010Z4N1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline-quinone synthase</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pqqC</name>
        <name evidence="4" type="ORF">CryarDRAFT_3469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone</text>
            <dbReference type="Rhea" id="RHEA:10692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
            <dbReference type="ChEBI" id="CHEBI:58778"/>
            <dbReference type="EC" id="1.3.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570430.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3431"/>
    <dbReference type="HOGENOM" id="CLU_080136_0_0_11"/>
    <dbReference type="OrthoDB" id="1571811at2"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00654">
        <property type="entry name" value="PQQ_syn_PqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011845">
        <property type="entry name" value="PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02111">
        <property type="entry name" value="PQQ_syn_pqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="15"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="25475" checksum="08EEC840CE77BC28" modified="2014-06-11" version="1">MAEAQPLTRPGLEAALRGLEPRYWSHHPFHVRLHAGRCSADEVRSWVANRWYYQQILARKNAAVIAACPLPDVRRAWLSRVSFHDDGGTDDWLLLADAVGLSLEEVVDERWVLRGVRFAVDGYLHFCRTRPWIESVAAALTEMFSPELMAARVVAWRAHYDWIKPDGYAYFETRIPAARADSADTLDLVLSHCVTRPQQDAAVAALAFKCDVLGAMLDAIDHAGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5Q5</accession>
    <name>A0A010Z5Q5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852610.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3841"/>
    <dbReference type="HOGENOM" id="CLU_126433_0_1_11"/>
    <dbReference type="OrthoDB" id="2018019at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13062" checksum="EAED4F5FCBFA592F" modified="2014-06-11" version="1">MNLALWVAASLLATVLLISTSKMFVPRERIAAVGHAGAWVMDFSPAALRGIAVLELLAAAGLILPAVLGIAPVLVPVTAACVALLFVGATGMRLRRGERATIVPDLLYLAVAVFVAWGRFGPEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6H0</accession>
    <name>A0A010Z6H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852954.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4074"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="461"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="548" mass="59093" checksum="AEF1D42634669BE6" modified="2014-06-11" version="1">MVDFNLAQVFQTVADSIPDTEAVVWRNRRLTYRELNERADGLARYLAGRGLGARRERAGLRGHESGQDHVGLYLRNGPEYVEAMVAGHRARLAPFNVNYRYVAEELLYLLTDAAARALVYHAQFAPQVREIRDRLPALDVLIQVDDDSGNALLDGAVAYDSVVGTPGDLPATSGDDLLILYTGGTTGMPKGVMWRQDDIYVAAMGGTPFGSPDPYPSYEAIAAAATANPGGQRVLMIPPFIHGAAQWSAFYTFTNGGTVILLDDTRHLSGAEALRLIVTEGVVSVPVLGDAVVLPVVEEIERAIAAGQPYDLSGLAVISNGGAPLSPGMRERLMRALPHLMLLDAGGASETGIQMSALSASGAMTEAGVFDAHEQTAVIDDTLTRTLKPGEGEGWLARRGRIPLGYHGDAEKTARTFPVVDGVRWSLPGDRAELRPDGRVRLLGRDSATINTGGEKVFAEEVERALLAHEAVRDVIVAGRPSARWGSEVVAIVELNEPVSDEELIAESARHIARYKLPKAVIRVPEIVRSPSGKADYRWAKEQVTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6K0</accession>
    <name>A0A010Z6K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853007.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_11"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010349">
        <property type="term" value="F:L-galactose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19163">
        <property type="entry name" value="AKR_galDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044479">
        <property type="entry name" value="LGALDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="303" mass="32062" checksum="0BAFC90E5245EEDC" modified="2014-06-11" version="1">MNTDLPLSALGLGAAALGGEYGPIDTAVAHATVRTALDEGITLIDVSPYYGRTAAETVLGDALRGVPRDAYVLATKAGRYDVDEFDFSAERVVRSVEESLRRLRTDHVDLIQCHDIEFGDLDRIVTETVPALRGLQEKGLVGAVGITGYPLPALVSVAGRVPVDTVLSYCHYTLQNSTLGERLPFFADRGVDVLNASPLSMGLLTDAGPPGWHPAPAAVRAACAEAAAHCRERGTTIVDLALRFAVGLPGVASTIVGAADPESVRRNVRWATGPLDEQLLGEVRAILAGVHDVDWPVGLAQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6M3</accession>
    <name>A0A010Z6M3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ORF">CryarDRAFT_4164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035865459.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4139"/>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_11"/>
    <dbReference type="OrthoDB" id="49441at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="156"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="466"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-122)" evidence="8">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="750" mass="81486" checksum="5AF58978DE848DC8" modified="2014-06-11" version="1">MSSPDNAPSSAQGVGGCPVAHDSVTSHGSESENPAIDSPKPKTGGRPHTNRDWWPNSLDLTVLRAHSSKVNPLGEDFDYATEFAKLDVDALKRDITEVLTTSQDWWPADFGHYGGLMIRLSWHAAGTYRTGDGRGGAGDGGQRFAPLNSWPDNANLDKARRLLWPVKQKYGQKISWADLLVLAGNVALESMGFKTFGFGFGRADTWEPEEIIWGPEDAWLGDERYVSDSEMAEDVGATEMGLIYVNPEGPRGSADPIAAAHFIRETFGRMAMNDEETVALIAGGHTFGKTHGAGIADDHVGAEPEGAPIEAQGLGWLSTYESGKGKDTITSGLEVTWTDKPTQWSNRFFEILYGYEWELTTSPGGAKQYVAKTSDEIIPDPFDPNKKYRPTMLTTDLSLRMDPEYDKISRRFLENPDEFALAFAKAWYKLLHRDMGPVSRFLGPWVAEPQLWQDPVPAAEGQLVSDADVASLKATVLDSGLSVSELVRTAWASAASFRATDKRGGANGARLRLEPQRSWAVNEGTGAVIEKLESIASEFNAAGGARISVADLIVLAGNAAIEKAAKDAGVEVTVPFRPGRTDATQEQTDVESFAVLEPRADGFRNYLRPGEKVQPETLLVERAYLLNLTAPEMTVLVGGLRALGNNAGGSTHGVLTDRPGVLTNDFFANLLSPGTKWKASETEENAYDITDVTTGEVKWTATAVDLIFGSNSQLRALAEVYASEDARDKFVTDFVAAWVKVAELDRYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLB4</accession>
    <name>A0A010ZLB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.474"/>
    <dbReference type="HOGENOM" id="CLU_015486_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="237"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="501" mass="53273" checksum="AB87CEC76E829435" modified="2014-06-11" version="1">MGPMTPRRLSARELIASALDEDSWESWDQPVTDPVDADESYRALLAAAREKTGVDEAVLTGAGLMRGRRVAVVVGEFRFLAGSIGVATARRVVAAVERATSEGLPLIAAPTSGGTRMQEGTVAFLQMADMTRAVTAHKAAGLPYLVYLRHPTTGGVFASWGSLGHVTVAEPEALIGFLGPRVYELLNGREFPAGVQTGENLFAHGLVDAVLPPEQVTDLAVRTLDILCSPRSGLPRVADVPREELADVPAWESVTRSRRADRPGVRRLLKYAAQPVIPLNGTQQGETGAGMRLALARFGAAPAVVLGQDRRGQTAESPLDPAALRTARRGMRLAQELRLPLVTIIDTPGAALSREAEEGGLAGEIARCLADLIDLPTPTLGVLLGEGTGGGALALLPADRVIAAEHAWLSPLPPEGASAIVHRTTDLAPEMAAAQGVRSRDLLRHGIVDRIVAERPDAADEPEAFLARLGRVIEHELVGLLDQEPRSRVTARTDRYRRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLF7</accession>
    <name>A0A010ZLF7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase regulator (Fe-S oxidoreductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848216.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.531"/>
    <dbReference type="HOGENOM" id="CLU_009273_10_2_11"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="42704" checksum="62978D0EEF390F3B" modified="2014-06-11" version="1">MAEAAGTLSQFILKVHSRCNLACDYCYVYNGPDQSWQYRPAVMPRQTMEIFGRRLREYLVDRPDVRPHVVLHGGEPLLIGTDRLDFLATSLTEALAPLGRRARMTVQTNGLLLDSTVLSLLLRHEISVGLSMDGGSEAHGRHRRTRAGTSSFDGSTRAAELLRSTPFRSLYGGILAVIDVRNDPVEVYESLLELEPPTIDFLLPHATWDAPPKEGSTAYAEFLIPIFDRWFDEPRLKVEIRLFASLLELALGGVGYSELFGPARPPAIVVETDGTIERTDSFKIAYEGACSTGLDIFSNSFEQAAEHRFFASSDGGVPPCDTCLACPVYRLCGGGMAAHRYRSGSGFANPSVYCDGLAKLAEHVQGRAERALASLPLGRDAPGSHRGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLG0</accession>
    <name>A0A010ZLG0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848223.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.536"/>
    <dbReference type="HOGENOM" id="CLU_013420_0_0_11"/>
    <dbReference type="OrthoDB" id="1388804at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="500"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="787" mass="83419" checksum="4F72B23A25E8E519" modified="2014-06-11" version="1">MSTASLADHYRALTDEQLERLFAARPDLAVPVPSDFSVLAQRAHSRMSVARALDHLDRFHLEVLDALRLVAGPNHRADRKEAMDLLRSAPDFSVRRVLDHLVTLGLAWPDGETTLRLPSMLDEVASRYTAGLGRPIAALIQDERTDDLTPVLAALHLPSVPQPEATALISDAFGDPVRLTALLDACPPEAIALLERLAGGGNPVGALRDVRRPTDPNDADTPGRWLLVHGLLVPLDASTVELPREVGLALRGDAPLGPVHPVEPAPAAATPVAKDRIDGAGAGQALEVLRQTASLLDACADDPPPVLKAGGLGVRELRRLARAAGVDEPTAALLLEIAHEAGLLARTSDADPTWLPTSSFDVWQATPAERRWAQLAGAWSSMARMPALVGTRDERDRAVAALSAEVTRSAAPTLRSQTLHVLVEYPGPLSEADIVGVLDWRAPRRGGRRRDEVVSEQLGEATTLGVLAQTTLTTFGKALVTGGDPIPALAGLLPDPVDHVLVQADLTVVAPGPLEPALSAEMALVADVESAGGATVYRVTPESVRRALDAGRSGSDLQSFFSARSRTPVPQSLTYLIDDMARRHGGLRVGAASAYLRSDDPTLLATVLADRRCADLGLRRIADTVLVSSTAVNRVIETLRACGYVPAAEDASGGLVLGWPEARRAPARPPRGAPRGANEISLDQDYLAGAAAAVRRGDEAARAARRAPVLTQPGEADPGAALSILQQAARDRARVWLSYVDAHGGVTARIVRPVSVGAGYLRAEDDRTETEHTFALHRVVSAIRTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLJ3</accession>
    <name>A0A010ZLJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="152" mass="16781" checksum="076CA44AC62752E1" modified="2014-06-11" version="1">MRNNEKVTVTDPHENDELAVRLRSATGRFFRRLRAERPAHGLTMTQISALFSISKGGGELTPRGLAEIERVQPPAATRTVAVLEERGLVRRAPHPTDGRQIVLSMTPDGDTLIAADRQAREAWLAARIAELDPSDRETLRAAATILERLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLR6</accession>
    <name>A0A010ZLR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848353.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.631"/>
    <dbReference type="HOGENOM" id="CLU_431914_0_0_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="389"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="675" mass="70609" checksum="9E36D617779C574C" modified="2014-06-11" version="1">MRDAPVGLRPVLNLLDRLRTTARLTLVIVLLVVPGAIATVEYALREGSQIAFTTAERDGVRVLRPTLHAMAAVVGGRDVDLTAIGSEVRSESSLGLRDELTAVSDAVSAGVTTPAGRLAAAQAFSALITETGNASNLILDPDLDSFYVMDTQVVQVPRILEAAAAAAAATGATGSSELVAARAVLAGQLSTAAEALRTDVETAVAQTSATGLEPRLADLRRLADEAAALAGRLTAALGTPGADVTGVAAAAEDAIDASEQALDGLLRTRADGLKDDRTLVLAITIVGFALAFWLAAAVWWRSRHDVALALRGVRAIADRDYGDHELPGGRDEFGDIGRALLQARERLIEQDEALKAAQLQQEQQVRENFAQQRRAEKQARQLAQQLIEESAEALTTELNDVAAAVEAVRTSAGTIHERVDAADGVLRSLLADASNADAVTTALGERLQRVAGMAKIIASVADQTKLLALNATIEAARAGEAGRGFSVVADEVKDLAATTAHSTDEITGTIQALEREATAVSSTITAMTAGIGGVDEATGALLGVADEQRATVVGMEQRLTNALDRVRAIADLRNMMERRGDERVPLTGTLVFSGGGRRLELRIKDLSQGGVRALPVPGEALPAGASGQVELPVPGVPPLDVDLLRQTDDEIVFRFRALPPAAATALHDFLQAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLV9</accession>
    <name>A0A010ZLV9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_0685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848407.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.671"/>
    <dbReference type="HOGENOM" id="CLU_043931_0_0_11"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="15"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="392" mass="41712" checksum="8D7E16E56AB30BAD" modified="2014-06-11" version="1">MVSDSSVRRRWLEPLDWVGLGLFALGLIGLVTGLVPLRDAEGTMHRVVPLLLFLGTVIVLAELTARAEVFDVVASWLARLGRGRYPVLFALCVGFATLVTAILNLDTTAVLLTPVMLALATRLEVAPLPFAMTTVWLANTASLLLPVSNLTNLLAADRVGLSPVGFALRMALPELASVLATAACLWLLYWRRRSSERYVVPERHRPPDRRLTAIAAAACVLFVVLVLVGVPLEAAAPVCAVVVVVAFAVRDRDALRWSLVPWRLLVLVTGLFLVMDAIGRLGLSDLLRTVLGDDPGLGRVAAVGAVLANVVNNLPAYVAVEAAVHPDALLGLLVGVNVGPIVAPWASVATLLWYERCRSAGVPISWWRFAATGLVTAVVALTAAVGALALVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZM01</accession>
    <name>A0A010ZM01_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725655.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.719"/>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="58"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="485" mass="51562" checksum="6C058C5AD2DB3CDD" modified="2014-06-11" version="1">MTSLLIVGGDVVTMAPGREVLTGATIAVVDGRIAALGTAEELRLRYPDADELDATGCVVAPGMINAHQHTTADPLTRSGIPDDIGAQDAIFNWAVPLHNAHTGGDDEISAMLTAAESLRRGVTTIIEPGTVAHPLRVAAGLRKTGIRARLNGWGWDTEGLPFAAPAADVLARQEEIVRELGTTDRVSAWITLLGHDLCSDALFQGAAELAERLDTRMTWHISPGENDIPGYAQRSGNRPVVHLHKLGVLGPRLLLGHAVWLDDDEVDAIVGTDTAVASSPGAYLRLGQGFTRAARHVEIIRRGGRVALGCDSHNANDVPDILRAAMLFAGLSLDRGDTDPVHAHEALALATIDGARAIGLDHEIGSIEVGKAADVVVYDTTDPVWTPRGDEALQLVWGMPSHTVRDVVVDGTVVVRDQRLQLIDYDDLRACAKENSHHLLRRTGIEPFRRWPRIAAAELEAASGGPAAPEAEHGAAGQTGEVQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMT0</accession>
    <name>A0A010ZMT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848752.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1025"/>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_11"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="36628" checksum="22F1A39FFD4F6EDD" modified="2014-06-11" version="1">MVNLEAFVAGLPKVELHVHHVGSASPQAVAELAARHAGSTNVPSDLDALEKFFEFRDFAHFIEVYIAVADLVRDPEDVRILTYEVARELARQQVRYAELTATPYSHTVRGMAPEAYCEALEDARAAARRELGIELVWCFDIPGEAGIPAAEETLRVSLDQRPDGLIAFGLGGPEIGVPRPQFKPYFDAARAAGLHSMPHAGETTGPETIWDAIRVLGAERIGHGTSALGDPSLVEYLVEHQIPLEVCPTSNLRTRAVASLDEHPLAGMVEAGMFVTINSDDPPMFGTTLENEYLVAAELLKLDAPGVAELAKAGVRASFAPEARKAELTAEIDAYTAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZN98</accession>
    <name>A0A010ZN98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808257_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="37357" checksum="46F6ABC9226FD911" modified="2014-06-11" version="1">MAVNVMAGPARLAPDQDTAEVARVVWGALTRQRQQLHQGRRCTASRSPLLRDAHSQHCLVCDELALDAQERVVVSWQRQAEREPWTHARIVSCAQSVLADRVRTRLSASGLVARPERWLEQKSFLPHVDPAGRVLLVALIVSVGYYTCIPTAGGRVRLGPQVVQPLIDGVRRGAFASALTRAWPSDDEPDLGKAAGHLAAALVAWRELRPEQYASLVGLAEANRTVLSLDVAGMRSDVEFTHLAGVPAGDDVAEVVIEQRGRWIVGTEHVAATSALLRRFLGRVQEVARSASAPAELRTLLVEEAEKLAAEDGNPSWLRELRDRPAVVSALIDRAAELIPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP73</accession>
    <name>A0A010ZP73_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849394.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1531"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="255"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="504" mass="54348" checksum="D37D51691B136039" modified="2014-06-11" version="1">MTEPLLRLSGIVKTFPGVRALDGVDLTVAPGEVHCLLGQNGAGKSTLIKVLSGAHQPDEGTIEWQGSEVRFVRPTAALNAGLATIYQELDLVDDLTVAENVFLGHEPRRLGFSSRGAARRRTRELLGRLGHAEIPAGREVGRLPAAGKQIVSMARALSHDARLIIMDEPSAVLAHDEVENLFRVIRDLTSAGVAVIYISHRLAEIREIGDRVTILKDGRTVAVDLPAKTTPTNEVVRLMTGRNVEYVFPQRAATTPGEPLLRVTDLGRQKEFSDVSFEVKAGEIVGLAGLVGAGRSEILETVYGARKAATGTVEMDGKPIRRGSVKAAVAAGMGLAPEERKSQALLLGEPVYRNVSLASLRRFSRFGFVRRGAERTEVGAVTRSLDLRPADPRRAMRTLSGGNQQKAVVSRWLLGRTRLLLLDEPTRGVDIGARAELYALIRSLADQGVGVLMVSSEVPEVLGLADRVLVVREGRVVHEAPASDLTEAQVLDLVMAGERVTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPB3</accession>
    <name>A0A010ZPB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1576"/>
    <dbReference type="HOGENOM" id="CLU_070584_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28736" checksum="D7C3F4AE289DA270" modified="2014-06-11" version="1">MVRHDRVVRHDDAVRIDDYVDVLRRDGEALSRAAERAGPDAAVPTCPGWQVRDLLAHLGGVHRWAAALVTTRRPDPFGAADEKRFFDAPADDALLGWFSDGHRDLVRTLTDADPALHCWTFFAAPSPLAFWARRQAHETAIHRADAEAATASAPDWEPGFAADGIDELLHGFLARRAARITADPAVSLALAADDVDAAWTVQLTPSGLLVDAGAHPPTLTLTGRASDLYRLLWNRSGSERLVVRGDLDALETWRHRVAINWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPD0</accession>
    <name>A0A010ZPD0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142746_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16321" checksum="37247E8CAD08DD5A" modified="2014-06-11" version="1">MWRDVPRRIRVPVFVLVAVMLYGGVVHVVQLATGGWPPYGWAPGWLAAYFTALTVLDPLAAGLVLARRASGLYLAAFVLVTDAAANAHATYVVTDGGIVPRIAQGVISVLAVGSVIVAWRAPTWVAGKASRRAGTASPGRGPRECDRTTRSRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQB6</accession>
    <name>A0A010ZQB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075791_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="23939" checksum="CAD5AE19714B4AB6" modified="2014-06-11" version="1">MNWTVGPHPSSVYWRRRLLLLVPLLLVLLVAASCLITSGSSGDKAQIAGVPKSSAASPAGGASPTDPGESGVGSAGASPSQESPDSATAAPEAPEQPAGGSTSAAAACPDSALTVTAVPSDGAVRIGEFASMKLTVKNTSNAACRRDVGSNEQELKILSGPTKVWSSDDCSSRADASAAKVDRKIVPGETLNYFIKWGGTSSSKNCVTGAPVKPGKYQLVARLGTLESKPAAFTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQB7</accession>
    <name>A0A010ZQB7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ORF">CryarDRAFT_1959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849978.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1923"/>
    <dbReference type="HOGENOM" id="CLU_034315_4_1_11"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="75"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="110"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="35021" checksum="C4F0EFE42575625D" modified="2014-06-11" version="1">MNHTWPSLLNTLLAREALAPEQTSWAMSRIMAGDATPVQIAAFAMALRSKGETAAEISGLVAGMLAAATPIDVSPDAVDIVGTGGDQAHTVNISTMAAIVVAGAGIPVVKHGNRAASSSTGAADLLEYLGVPISMTPELASVCVREAGIAFCFAPIYHPGMRHAGVPRKEMGVPTFFNFLGPLTNPGRVRASAVGCANLRMAPVMAEVFAQRGASAVVMRGEDGLDEFTTTAPTRLWVVADGSVTETVLDAADLGIPRAAREDLRGADAAFNAKVARSVLAGDRGPVRDAVVLNAAAGIAAYDGFSGGLEASLRAGLEKAATSIDSGSAGTALDRWIAVATQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQL8</accession>
    <name>A0A010ZQL8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CryarDRAFT_2069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850116.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141508_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG80974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="157" mass="17171" checksum="49423B92085CDB48" modified="2014-06-11" version="1">MAKKRFRLATVLRARQAKEDALRGEVLAARAALREAELMVERSGETLRGRQLPESALARSYVAAISARQALAGELFAAQRVVVDAQEAVAAKLRDYTDASQARRAVEKLEERHKAERAAAELAEDQVLVDELATTRRSRTKPPMDNTENSAGGDEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR24</accession>
    <name>A0A010ZR24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NB-ARC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570021.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2192"/>
    <dbReference type="HOGENOM" id="CLU_004665_2_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="788" mass="84652" checksum="5C43B973FD81AD9E" modified="2014-06-11" version="1">MAVAETGGLPDPGRARSLDDLAGCLRALKVWAGDPSYETITRRINGRRRTTGRPEHERARRGTVVDCFKAGRRRVDEELVLEVVEALHAEPGYLVHWQQALRAAVAGARAAAQVRVLDRLPDDVPGFVGRDAELARLTAHGSLVALITGMAGVGKTQLAIHAGHLLAAEQRFETTLFVDLRGFHPDPAQPPADPGAVLDAFLRLLGRPGHRIPPGLPAKVALFTELLAGTRTLLVLDNAADEEQLRPLLPAGGDAVTVVTSRRALPRLDADVRLDLDVLSAGEAEALLVAAAPGLAIGADATAYRRLTTRCGRLPLALSVVAGQLVGRPGWTVTDHADRLDERSRDRRLETGVELALHLSYQHLPTPRQTLLRRLAAHPGPDFDVHACAALLGVGPDEAGAALRGLVDEHLVQRSDAERYVLHDLVGAYAAERARDDERPSDRRDALTRLLDHLLHAAAAAMNTLSPAERHRRPELPQPSATHLEFTDATDARAWLDGERTTLIAACAEAAGAGRAEYVVRMAGTIYTYLDNGGYPADAVTVHTRARDAARQLGDDVAEAVALTNLGMAWWQLGDYATAVSHLRQALAVHRTAGDLRGEARALGNLGVVYSTSGRGDLAAEYQRRALEVFRQVGDRVGEANTVTNLAAAHAQLGHPAEAIEYSRQGLVLFRDLRHRGGEATALTNLGDGHLALDECETSVEWYRQALTIFRDLGERYGECCALNGLGRALAGLRRGDEAAECHRAALALALEIDNPDEQQRATTALAHLVTTGDHDPIGGCRSRGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR87</accession>
    <name>A0A010ZR87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850378.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192631_0_0_11"/>
    <dbReference type="OrthoDB" id="2213158at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="12168" checksum="684773C417838F40" modified="2014-06-11" version="1">MPGSESVSTLPAHLVDEFRHVLADLSGRWLLPSADWEAVESWVGRGEDALRTGDRDEFTQVVRELAFYGSGRAVDASRGSREGPPPRLRERTRRIIHTLRPPAHDEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRG7</accession>
    <name>A0A010ZRG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850475.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2302"/>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="248" mass="27003" checksum="C3E574039C452C92" modified="2014-06-11" version="1">MTGSQGDPAKLPAKRARRTVLKAAEARTNTRRGLIEQEIYVHATRLFAERGFAGTNFQDIADAVGLTRPALYHYVSSKEELLAKLVAEITQDAATDIAAEAERTDTGPAEKLHSIVASTARRQGEHADRFRLLVRSEADLPVEIATTHEAGRRSVLKSIAGVIEEGVHSGVFRTVDPRVAALGALGMANWVAWWYRPGGRDDLVKVCDELADMAVAGLRGRDDGRAPQSTAEALSAVREDLDRLERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRN8</accession>
    <name>A0A010ZRN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2352"/>
    <dbReference type="HOGENOM" id="CLU_039030_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="42182" checksum="54E4483303A738CA" modified="2014-06-11" version="1">MTAPHGGAPDQGAPRSGAPASTQRVFPCTNCGATLEFAPGTESLRCPYCGSAQHIEIAADRVVREHAWDEFVRLPRKPVATLAAYVFTCPGCGAVTESDAISDRCQFCGAPVVASVDGGEMVVPEAVLPFSVDRPRVREALQGWVKSRWFAPNALKKVTTAESVRSTYLPHWTYDANTSSHYTGERGEYYYETETYTVRDSDGQERTETRQVRKTRWWPASGHVSRDFDDVLVRGTSKVPSDHLDALEPWPLPESKPYDPDYLAGHQTLRYDVEPEEGMGVARGRMASVIEQDCRRDIGGDEQRVHSVNTSYSRVMFKLMLLPVWVCVYLYAGRSFQVLINGRTAEVAGQRPYSKVKIALAVIAALLVVTAVVLFFVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRU1</accession>
    <name>A0A010ZRU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850660.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044677_0_0_11"/>
    <dbReference type="OrthoDB" id="1868844at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="13419" checksum="9EA89597143BF756" modified="2014-06-11" version="1">MRLRPDDDIYRAKLLFLGPKGFTLPVHLPYVAYPLFAVVLAVIIFIRYLLTQEVDYFPAIEIALSIVLTSVILRQVSPDRPVRAVLRTAATDWRRDRTAGERGGRARSRIVVRETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRZ6</accession>
    <name>A0A010ZRZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850751.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2504"/>
    <dbReference type="HOGENOM" id="CLU_003827_7_3_11"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="245" mass="26136" checksum="5AABABF72D833140" modified="2014-06-11" version="1">MVRRLSWQVGTVAAVRDETATARTLVLDVPDWPGHLAGQHLDVRLTAPDGYSTERSYSISSASAPGRVEITVQVVDDGEVSPYLARVLSVGDPLELRGPVGGYFVWRPGAESPTAAEPVQLIAGGSGIVPLMAMVRARAQAGSDAPFKVLYSVRSPAEAIYPSELAELGVEVTYAYTRRTPPDWPLPPGRVGAGLLAAHTWTPDDKPRVYVCGPTPFVETVANLLVDAGHDPASIRTERFGPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSN1</accession>
    <name>A0A010ZSN1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1273"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="347" mass="39805" checksum="A7DD8F3B8D3EE145" modified="2014-06-11" version="1">MAGDTAVRSEDAFDVGTVHEWLAGRVDGLDAPPEVRQFSGGASNLTYLLRYPDRELILRRPPAGRKASSAHDMSREYRVQKHLKPVFRYVPEMVAFCDDHDVLGADFYVMERIVGTIPRKDFPPEVQLDPVQARTLAFTVVDTLVELHDVDPAAAGLSDLGRGAGYVERQVRGWSDRYRKARTWNVPKAESVMAWLDEHRPDDVKSCLIHNDYRLDNVVLAPDDPLRVVGVLDWEMATIGDPLMDLGGALAYWIQSDDPYLSQRARRQPTHLPGMPTRREVVEYYCDRAGLSSANWAFYEVFGLFRLAAIAQQIYYRYHHKQTRNPAFRQFWLNVNYLVWRAHKAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT28</accession>
    <name>A0A010ZT28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851297.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303205_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22215" checksum="94EEC9F0EF16D9D3" modified="2014-06-11" version="1">MVDAQNQGWRLATTTGRYAADFGVPRGLRAAVSYSELAATRGPIRPVVPAPDADRDALLRAFRAAGPRAALSLLVALQQVFRAAADGGTEYDSARRTLIAGSEESWEAAHLTMLLGRTAPGGSIDSPTVGTIVGVLCPWVTRPDVYVEVAQTLSAVFASFLDEDVDGRPRGWSGAADASLQPGSAAFETNGGRLLYSWLAARSRRSRLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTC9</accession>
    <name>A0A010ZTC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851481.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3049"/>
    <dbReference type="HOGENOM" id="CLU_041141_5_0_11"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="315" mass="33974" checksum="7D5FE315F7770E6B" modified="2014-06-11" version="1">MRADRLMAILLLLQQREQLTAADVARELEVSERTARRDFDALAMAGVPVYSIRGRGGGWRLVGGARTDLSGLTAGEARALFLVAGPASAATPALKAALRKLVRALPEPFRVQAEAAASSVITDPQRWGSSPVERRSPRWLDALQDAVIRGVQVRLGYVDSVGAVTERIVHPLGIVAKGPSWYLVGTTDAGRRTFRIDRVSSADPTGEPVHRPDDFDLAESWREIADEVDRRRTPLEALATCAPDGVARLRMILGDRLEVGGATADERIEVVIRGYNAYALAGELAGLVEWLEVTGPPGVRDQLASIGAALVERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTF5</accession>
    <name>A0A010ZTF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1559"/>
    <dbReference type="HOGENOM" id="CLU_014658_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="629" mass="67478" checksum="D40A161C1396087E" modified="2014-06-11" version="1">MCGIAAVFSLGDRPLVLADRGTAAAMADAQRHRGPDSASVNDATHSAMRFGRLTVNGGPDGEQPFTDPTGRWLIAVNGEIYNHAELRRRHRLPASDADCRVLADLVPLLGDATFAQLRGMFAAVILDSRERTLRLVRDPFGTKPLFWAVRGDRLYVASELKGLFASGRVAAEPDWADVLTGSAFLSARRGVLRDDVTHFRDVHTVPPGAIVTVDLATGAIGSRRYHSWAIGTGPVTEPEEYVDEYRRLLRRAVDRACLSDAPVTLLLSGGIDSVAVAALAAEHRQLTAWTVLSASTQDTDYPAAVRAAAGLGLPLGTADTRTTEQALDLADWCWVLRTTETPLAGPEQYYKLATLHAARTAGDPYTVVLTGQGSDEFNGGYSAGFAHDPPGGWDGFLDALRLGRQRHALDRLPGATRALGEHLPEQWLNDDWLRTQIPDLPSDPYEYWITAMRAGLQQYNCWHEDRMAAAFSAESRPVFLDVDLVAHALSVPPELRPDLLWDKRILRQAITPLLPDPALADRPKGAFHLQAGQRIGQAAIVGLLTRHGDALIEMATAGPTGSRVLAPSALRTGLATVVADPDLTGLNSLLRLLSLGALETLLSADSPSAVPGPAVTGAGAGELIAGVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTI8</accession>
    <name>A0A010ZTI8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851528.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3110"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="371" mass="39140" checksum="C28E381584F7865D" modified="2014-06-11" version="1">MGEAFDRVGRYTIAQALGSGGMGEVYLGYSPAGDPVAVKLIREDCLNTLVRARFEKEALIARTVVGTNRVARFLDAEPLADRPWLAMEYIPGATLQAWVDANGPLPDVLVASLGALLAEGLAAVHAAELLHRDLKPQNIILGDYGPVIIDFGLAAFTDAGLGSLSRRGMIVGTVRCMPPEQAEGNPQVTTAADVYALGTVLLYAATGHYPYDGPTWQSIVLQVANPALEPDLTGLPGALRPLITAMFAHEATDRPTLDTVTSTCADLLRLADVHPVVARRALIDRTTAPSSPRVVSTLTLSIEDALSDLAGGSADEGFRLDQEETPASSTASDAAESPKQASDHERPAPRSSPQARIAAQLRDAYAVGAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTS0</accession>
    <name>A0A010ZTS0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570327.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538849_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="18520" checksum="6AE2A79BC834C0B4" modified="2014-06-11" version="1">MKHTGRTTLDVPLDRVDLSDWLFTLSDAEYQAAAPTAHRAAGITVQDGVRGTVNVEAIGGHLIIQHYREVTASPTHVEMHSRRSRVYLFHLVPAHLQVRWTMSATEQTAETSEFLCTVELILSPLLRVLGGMSGLSPAIRRHTRIETVGFARDIVRKAKAKPAPHAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU05</accession>
    <name>A0A010ZU05_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849706.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1742"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_13_11"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="16250" checksum="3AC28E64C9468F7A" modified="2014-06-11" version="1">MTRAPGDLLVHLRRARDHADRHYREPLDLERLAAVAGLSKYYFARMFAATYGITPAAYVSRRRVERAQDLLRATNLTVTEVCAAVGFASLGSFSSRFREIVGETPSEFQRRWAATGAPHIPGCFVFMWGLAETSASQEKRPDADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU74</accession>
    <name>A0A010ZU74_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570385.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3353"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_11"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="46490" checksum="1A8DACF8CCD3BEFB" modified="2014-06-11" version="1">MTPATLPKELDGKVVLPSDPRYRLLRSTYTRVSRPAMVVLPQSVTDVVVALRYARDSGLPIAVRSGGHGLSGRSSNDGGVVIDLSGLNEVRVLDRKTRLVRVGVGARWAEVAQALKPAGLAISSGDHGNVGVGGLATAGGVGWLVRDYGLTIDHVRAAEVVLADGRVVRTDAEHEPDLFWTVRGAGAGVGIVTAFEIEATELRDITVAQLTLAVDPDGSTLTRWAEHLARAPRQLSTAAMLMSHGRQAILSLTAVYAGTDAGRVRGAVMPLRKIGALLDQTQQSASHAALVSTAHLHPNLGQQPTDTTNGLLPTMTPDVARAITAAVTGPRPALMQLRSVGGAVNDVAADATAYAHRHSTVLVVGTVFPPHDRTTLDHIWRPIGAYTRGAYANFESRLDAAAFRRFYPGATGDRVLAMWRHHDPDGIFRSTLYPGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUE2</accession>
    <name>A0A010ZUE2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057475_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="119" mass="12423" checksum="48CD749AA104306F" modified="2014-06-11" version="1">MTEGVVSSPRERLAVVAFVLGLLGFLGGLPYLDMYGIGFAFIQPGLTPGLVLATCSVAAVVLGPIAFRRCERRRRRGSSLALAGLIGGALGLPGLIVAISVLRMADEGGLTADFTSWCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUR2</accession>
    <name>A0A010ZUR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="9" type="ORF">CryarDRAFT_2042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861593.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2007"/>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_11"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="189"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="391" mass="40634" checksum="2FD7AD659ED18BA7" modified="2014-06-11" version="1">MIKVLVVDDSVVVRRLIVDALSDDPGIEVVGTASNGRLALAKIEELKPDVMTLDIEMPVLDGIGTLKELRPKHKRLPVIMFSTLTANGASATLEALAAGATDYVTKPANVGSVRESIKSVREQLIPRIYALGPKQRPAPGRPGLPPGRPGTAPPGRPGAPLAGRPPLGAPAAPSGGIRAPMRPAKSKVPGQRIDVIAVGCSTGGPDALAKVVQGFPKDLPVPVVVVQHMPPIFTKMFADRLDRASAVKVVEATADIPLDAGTVYIAPGDKHLEVVRKGTSVLTKLHEGPPENSCRPAVDPLFRSVASVFGAHALTVVLTGMGQDGKKGCEVLARVGSEIVVQDEETSVVWGMPGAVAQAGLADVVLPLGSISDTLLARVGHGRANRLAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUT0</accession>
    <name>A0A010ZUT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852254.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3603"/>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="154"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="30974" checksum="B98B2024913EABEE" modified="2014-06-11" version="1">MTITPVVTVGIDGSESARAALDWAVEYARAHGASLRLVNGLELPEPSPAYTPYPIGDVRDAVEKEACEALDAARTRVHETAPEVEVTTAVVAHPPVPALLEASGHSALLVVGCHGWGEFAGLFLGSVSASVTAHAACPVVVVRGDGAGRTAAPVVVGVHGSGDEDATLETAFGEAARRRVPLVAVSAWSDVTLENAAGAIVGAWPTWDRLREEAGHRLEATLRPWRDKYPSLHVGTMVVRDRPAAALLDRSAEAQLLVVGSRGRGGFAGMRLGSVPRRLVHHAHCPVLVVRHAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV62</accession>
    <name>A0A010ZV62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852474.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3744"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_11"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="24623" checksum="27B8CC7A9F28FA92" modified="2014-06-11" version="1">MTAPTVTLVTGGNRGLGFELARRLVDAGQSVWIGARDAERGRAAADRIGARFVRLDVTDDASVLAAAETIRAEAGHLDVLINNAGILGEVTPPEEMTVEHLRPVYETNVFGTVRVTHAFLPVLRAATTPSVINITSGVGSFTLINDPDRVESQYPLAAYGSSKVAVTMLTVQYARTIPDVRFNVVDPGQSATDFTGGLGHSPQEGTDAAVRLATLGDRTPTGTATDRDGVLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVI3</accession>
    <name>A0A010ZVI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850439.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2285"/>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="177" mass="18193" checksum="E18926245973524E" modified="2014-06-11" version="1">MRADARRNYEQILAAAEAEIARSGAGASLEEIARRAGVGSATLHRHFPSRQALLDAVFHDRIEGICARATGLVDADDPGVALADWLRALAVYGATTRGLAASMLAGGLAVPSSSGCEAMLADAGATLLERARAAGAVRPGVTIGDLLTLVNAVSLATENHPDTAERLTTLALTGIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVM7</accession>
    <name>A0A010ZVM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852672.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3910"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_11"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="444"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="535" mass="57858" checksum="BDECC3577E7EA70F" modified="2014-06-11" version="1">MRGLMQDRPLTIPTLLSRVETNFGHKRVVTGDTVSTWSEVAPRVRRLARVLDHLEVPAGACVGTFAWNSQRHLELYLGIPASGRILHTINHRLFGEQVTFIVNDAADDVLFVDRTILPVVWPLVSSFRSVRYVVVMDDGGDFPLPDDPRVLDYEALLGRQSGEPLELAVADENAAASLCYTSGTTGNPKGVLYSHRSVVLHSLLLLGADVFALSERDVVAPIVPMFHVNAWGLPYAAMQCGADLVLPGPDTTPEQLVTLLSRHRVTFSAAVATVWRDLVPLLAGHDLSSLRHIACGGGAVDDALSRAYETTIGIPLTNAWGMTETSPVVTTARLGTHHAGLTPDERRLRLGTPGPAVPLTELRVVADDGALPPRDGSTPGELQVAGATIASAYFGADGGADSFTSDGWLRTGDVATIDRWGYLRIVDRTKDLVKSGGEWISSVELENAIMADPRVREAAVIGVADPRWGERPVACVVPAPGTHLTGDDVRAHLRGRVASWWIPERVELLDEIPKTATGKWSKHTLRQRLGARHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWH8</accession>
    <name>A0A010ZWH8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850943.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2655"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="33353" checksum="32E5232F2907A322" modified="2014-06-11" version="1">MRRVRYYEYGGPDVLRVEDAGIPEPGPGQVRLRAEVIGTNFVDTRFRLGPAGGALFARPLPGRPTGDVVGVVDTIGPGVDASLAGRRVGALVAEDAYAEYSLAGADDLVPIPDGVDDGTATTLASTAPVALGVLRLGRLAAGETVLVHAAAGGIGHLIVQLARQRGARVIATASSASKLEFARSFGADAGVDHTAADWPEQVRAAAPGGVDLVVDAIGGDVLRQSVDLLAPFGRAVVYGAAGGELTSVPVTSLFGLRAVLGFSYLAWRAAAPAQARDVIAELTRDARAGRLRAAVHARLPLADAAAAHRILDDRVQHGRVLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX64</accession>
    <name>A0A010ZX64_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroshikimate dehydratase</fullName>
            <shortName evidence="1">DSD</shortName>
            <ecNumber evidence="1">4.2.1.118</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36241"/>
            <dbReference type="EC" id="4.2.1.118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial two-domain DSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.118" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851254.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2889"/>
    <dbReference type="HOGENOM" id="CLU_029438_0_0_11"/>
    <dbReference type="OrthoDB" id="402639at2"/>
    <dbReference type="UniPathway" id="UPA00088"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046565">
        <property type="term" value="F:3-dehydroshikimate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02238">
        <property type="entry name" value="DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043700">
        <property type="entry name" value="DSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="432"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="617" mass="65424" checksum="36B561831E68E18A" modified="2014-06-11" version="1">MRTAIATVCLSGTLEDKLVAAADAGFDGVEIFEPDLVASPTSPGEVRVLCRDLGLSIDLYQPFRDLDSVDPGRFAASLRRAERKFDVMAELGVDRVLVCSSVGPDAVTDDGLLAAQLTELASRAAARGLRIAYEALAWGSHVNTYEHSWDVVARADHPALGVCLDSFHILSRGSDPAPIAGIPGEKIFFLQLADAPHLSMDVLQWSRHHRLFPGQGAFDLPAFLRPVLAAGYTGPLSLEVFNDVFRQADPGPTAVDARRSLLALAEATALAGAGARASAVVADPVAAPAPVLGGHAFVELLAEPAEAVRLGGVLASLGFVRTGRHRSKPVERWEQGRARVLVNAAGTGGAALGALAVESADPPAAALRAQRLLAPLLPRERGPAEADLAAVAAPDGTPLFFARTGDFAGGWSSDFVPDPDGRPAPAGSGVTRIDHVGLSEPFDHFDEAALFYRSVLGLTPVTAGEFAAPFGLIRGRALTDDARSVRLALTVARLRRGDWAPAVADPQYVAFATDDVVAAARRARDAGAPLLAIPDNYYDDLAARYELEPRDLATYRELGILYTRDDGAYLQVGTQLLGGRLFLLLVQRLDGYDGYGWADAPVRMAAHRRNRLVRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY36</accession>
    <name>A0A010ZY36_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3226"/>
    <dbReference type="HOGENOM" id="CLU_057678_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="42459" checksum="206A1DB886445B87" modified="2014-06-11" version="1">MRPVAGKPYSRKMSLAERVQLANPPGIHTYIQLFVEGTGTLDPRALSAAVAAASDACPGARLTRRGRRWVDSTTPPAVRVHDGDTLDRYTFDGLDTMFRPLSGQCGAPTCEVVQLTGARPGLVFRVHHAAMDGMGLLLWAGEVFRALRGEEPQPAVSDLTMSDVLRAHGPGERPPPPRMTSAPPLRARATLERRGTFFLRRTLPTPHWASVPKIAVALTRLCALGTGYFTIPIDLRRHVPDVRSTANLSGAVLVSAAEDATWLQVYRQLQRALTANQDLWTLGGPRLMDAFGRLPMGVLRPMVRTADGLLARGGVPQPAFALAHFGLLDLAAYSGGGFAASTAYVLPTCGLNVMPVLTIVETAKRTELVLCGDDGPGMAGLGGRLLDGIKTSLAALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZE4</accession>
    <name>A0A010ZZE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LmbE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852496.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3753"/>
    <dbReference type="HOGENOM" id="CLU_049311_2_1_11"/>
    <dbReference type="OrthoDB" id="1380748at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="261" mass="27726" checksum="2FE48AA1A8DB1FA1" modified="2014-06-11" version="1">MILVSFHAHPDDEALLTGGTLARAAAEGHRVVLVVATLGGAGLAADPRGEALAARRHRELLASAAALGCARVEVLGYDDSGLDGAHPAARRFADAPAEQAAHRLAAILRAERADVLTSYDVHGGYGHPDHLAVHRVGARAAELADVPVVLEATIDRDSLRLLLRALGLARRWLPALPLGDAVFTPRAEITHSVDVRRYLPQKRAALRAHVSQGEGGRGPRTITTLLRLPGPLFTLVAGREWFVQRGEHPAGLRSPFLEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZK5</accession>
    <name>A0A010ZZK5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852590.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3824"/>
    <dbReference type="HOGENOM" id="CLU_1127198_0_0_11"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="26734" checksum="B75E9A795F493C96" modified="2014-06-11" version="1">MDEVEIVVAHRQRATLRVGDVFVKLDGDPAHAEIEVRAMALAPIPTPPVLWHRPPALAIAAVPGTALGVLGEPSAASPAAWAAAGAALRRLHEAPPPPWPGRRLDDLAAELERECAWLLAHGALPAEVIRRNREIAGAALRPWHPAFIHGDLQITHVFVDGDAVTGVIDWSEAAPGDAHYDLAILTLGHPERLDDLLAGYGADADRDVIRAWWSHRSLVASRWLIEHGFDPDAPGCEFDVLRAQLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZY3</accession>
    <name>A0A010ZZY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_3963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852690.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3934"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG82762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="609" mass="64070" checksum="C2A4260A283B510B" modified="2014-06-11" version="1">MSTTSAEPVRTTVGAAFRLAGRAAPRYLAGAVAVAAASAAAPAATAWLTRATVDGIIARAGAGELLALVGGLAAAGIAVGVLPHAATYARAELGRRSAVHALDELYRAVERQVGLRRFEDPPFLDRLRMAGSGGRAPGELCGAVLGAGTGLLGAVGLIAALALVSPLMTVVVLAAAVPVLVMELTLARQRAAVLWRMSPAARREFFFGQLLGHPVAAKEVRLFGLAGFLRERMLSEHRAIDVAQRRVDRRALATQGGLALLGACVAGGGLIWAVFAARDGRLGVGDVTMFVVTVAGLQAALAGLVSSFAGAHASALLFAHHRAVLATAPDLPLAVAPRPVPVLHRGIELRDVWFRYADDKPWVLRGVTFTIPHGLSVALAGHNGAGKTTIVKLLCRLYDPTMGTIHWDGVDLRDVPIDDLRRRIATVFQDYMEYDLTAAENIGLGDLAARHDRDRITGAARLAGIDDLLAGLPQGYDTMLSQIFAVGDDPDDPETGTMLSGGQWQRVALARALMRGERDLLVLDEPTAGLDAEAEHEIHARLRAHRAGRTSLLISHRLGAVADADRIVVLRDGVVAEEGDHTGLMAARGTYARLFALQASGYTRTGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0A1</accession>
    <name>A0A011A0A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sarcosine oxidase gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852983.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4094"/>
    <dbReference type="HOGENOM" id="CLU_1774291_0_0_11"/>
    <dbReference type="OrthoDB" id="1585635at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007375">
        <property type="entry name" value="SoxG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04268">
        <property type="entry name" value="SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15253" checksum="7BCF3BDAC583FB6B" modified="2014-06-11" version="1">MAELLRTHALESRVEALAAAGIVVEPYVAMTNVRGADAPPAGIRLGPDEWLVVGAAGEPGGSVTDVSAQWITLRLTSGHARDVLATGCAIDLHPRAFPEGTSVQTRLAQAGVILTSLGAGGYRVLVRSTFAGYLADWLLDATSEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0E6</accession>
    <name>A0A011A0E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853066.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4143"/>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="24842" checksum="64219AF756A3682E" modified="2014-06-11" version="1">MVNESSRERLTAAAFALFEEQGYEQTTVEDIAARAGVGRTTFFRAFGSKDDVIFPHHESLVVAVRDRLTAAAPDAGVPAIVEGARLVLTHYLDEGDLARVRYRLTRTVPALRHREISGMQQYQRLFREFAASRGIGGDPLHAELLANAVVTAHNYVLRRWLREVGADPLDEFDRAMADVLRLFGGSAGAADERAAVVVFRTTRDLDAVLPGIRLVLEDARPETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABJ9</accession>
    <name>A0A011ABJ9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_0431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848005.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.415"/>
    <dbReference type="HOGENOM" id="CLU_012862_2_0_11"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="39"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31783" checksum="AC38FF81577C5326" modified="2014-06-11" version="1">MSETRFAALVLDWYDENARDLPWRTDDATPWGVLVSEIMLQQTPVSRVLPAWVEWMKRWPTPAAMAADEPGEAVRMWGRLGYPRRALRLHECAVAITTRHGGELPTDLDALLALPGVGAYTARAVASFAYRQRHAVVDTNVRRVLSRVVTGVADSPPGSAARDLALAEPLVPTDAAVAARYAVAVMELGALVCTARAPRCADCPVVDDCAWFRAGKPAYDGPVKRPQGYAGTDRQVRGRLLAVLRDAEGPVPQAALDVVWHEPVQRARALDGLVTDGLVDPLPDGRYALPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABQ7</accession>
    <name>A0A011ABQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter ATP-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848125.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.483"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="362" mass="39100" checksum="A814F432E61C7D63" modified="2014-06-11" version="1">MATVTYQGASRIYPGSTKPAVDKLNLEIQDGEFLVLVGPSGCGKSTSLRMLAGLEDVNEGAILINDKDVSHLPPKARDIAMVFQNYALYPHMTVAENMGFALKLKKTPKAEIAEKVRDAAKLLDLEEYLDRKPKALSGGQRQRVAMGRAIVRQPQVFLMDEPLSNLDAKLRVQTRSQIAALQKRLEITTVYVTHDQVEAMTMGHRVAVLKDGLLQQCDTPRALYDRPGNAFVAGFIGSPAMNLKTVPLTDGGAQLGPIVVPLTREQVAAAGEGGSKNVTIGFRPEAIEVVSDGTGLPLVVDLVEELGSDAYVYGHSEIGGDDTRIVTRTDGRKVPTLADTVHLQINKDDVHVFHAGTGARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABW0</accession>
    <name>A0A011ABW0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848236.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.544"/>
    <dbReference type="HOGENOM" id="CLU_125944_0_0_11"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="14167" checksum="37534E470A0320C8" modified="2014-06-11" version="1">MPTGKVKWFDPERGFGFLARDEGGDVFVHKGALPQGVTELKPGTRVEFGVAAGRKGDQALSVRVVDPLPSLVSQTRRPADELHGMVEDMIKVLEARVQPDLRRGRYPDRKASRKIAELVHAVARELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC14</accession>
    <name>A0A011AC14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569664.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.604"/>
    <dbReference type="HOGENOM" id="CLU_031275_6_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="506" mass="54963" checksum="56DFAB8CB8BB1B15" modified="2014-06-11" version="1">MAKRERRLAVPAYARAAWRRVAAGRAGGRHRGTADPAAVPPTATSAPDPETEHERHHPRRAASVDDLGDTAFGLEEAERHRRTAADRRRNDLMPRWLPRAFVLAALTVSGFFLTWWLLGRLRNLIGLLLLAQFLAFALEPAVNWLARRGWRRGAATGVTMLIVLASLIGFMVAVGSLLVSQVTTLSARFPQYLDLAVAWANDKFDTKISIQQIQNQVVADDGPVRRWLEGVASNAVDLSTSVFGIIFQALTVILFGYYLCADAPRVRRSLCSVLPPARQRDVMRAWEIAVDKTGGYLYSRIVLALVSSLAHYIVLSILGIQYSVALALWVGLVSQLIPTVGTYLAASLPLIVALVADPFDALILLVFVVIYQQVENYLLQPKITARTLDLHPAVAFGAVLAGAAVLGPIGAILAIPFTAISQTFVGSYIRRYEVEEHPIHDPKAMAKIPIEPAPPVPPRHGDDAPHHEDGSLASPAPPEPSIGEPAVAPDQPLVVPDVDPGPRDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACH3</accession>
    <name>A0A011ACH3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569708.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.762"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="858"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="920" mass="98441" checksum="D789D05C88C1D300" modified="2014-06-11" version="1">MLIPPEISARLDDVHAVVVQGPPGIGRTSLLRQVAATADGSEVLTAEGVETETGLRFAALHRLLMPLADRIPSLPKRPAATLARMMAGDAPAGLPLGVAVLELLTRAARRQPVRCCVDDVHLVDDASRDVLAFVARRIASEPITMLFTMPDDRPPLPGLPSATLPGVDAVQFLAGTVPADVAAAIGRGCGGNPRAIEELTRTLSADQRDGRAPLPETLPLYGRVRREYDARLARLPVAARRLLLLVAADEQVDVRTLGRAAAAAGGDLSALAPAEAAGLVHEADGSMRFRFPLLRGAVYHAASDDDRRAAHRLLADVLAGEPAGADLRAEARRHLRRAWHLAALTPPPPDGPTAAGRTKADVGNGGGSADGERGAVAEELTRAAEVVRGNGDHAAASEAVERAAELTANPDDKAEHLLAAARDAWLAGRPHRAGVLLARLRPPHPEAALLGFRDLLRGEIALRTGTPTAAQELLLAAADRLGEPHRTAAMIALIHASEVDFVSGDERRYLRTLHRVIALRRGDESGAAELMFEFCTGMAATFERRHADAVAPLRRVLELSTQHHDPTLLSWAALTACILGQEDTALGLSVRARASAQVRGEIAALPRTFELSTYAQLWLGRHAGATSTADEGLALARSLGQPGSASFQLASLALLAVPRGDEPTCVVRARAAIAEADDRGPGMSVAMAHWALGALDLTVGRTTEAMARLRVLVTASGRSHPLVRMMAAPHFVEAALRYGDRGAAATVGGHFDAWANATGSPAPMALAARCRALVASDPAVAEENYREAMRLHRLGRHEFERARTELLYAHELRRRRGAPAAREVLHDALDTFRQLEAEPWVRACQGELRATGEDVRPERAHRPDLTPQQLRIARFAAQGATNREIAAQLYLSVRTVDHHMRNIFVRLGVRSRVELVRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACN6</accession>
    <name>A0A011ACN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848572.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.826"/>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_11"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="29968" checksum="E33561F4E3F12224" modified="2014-06-11" version="1">MTRDIAVTGATGQVGRRVAARLAAADVPHRLLVRGSATALDGPAATVSIGAGYADAPAVRSALDGVGTLFLVSGRESADRVAEHRTIIDAAVRAGVERVVYLSFLGAAPDCTFTFGRDHWHTEQYLRGTGLGFTFLRDSFYTSMLPALVGPDGVLRGPGGTGRVSAVAPTDVADAAAAALVAAAPDQQTYELTGPVAISLDEAAEELGRRVGRPIRYQAETVEEAYASRAGYGAPDFEVAGWVTSYVAIADGSLSRVGDGVERLTGHPPLTFAHYLDANPESYAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACZ6</accession>
    <name>A0A011ACZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848698.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924084_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14578" checksum="825B89442F986495" modified="2014-06-11" version="1">MSGETVDQLWNSLVDQHMDAIWGIATTAGLDLAEASVISQLTWLRMAERWTTVRALARTKDPSLHPVEQPTTQVDEWILHTARSEVDAWLRDERRRSREALFADGGVVRMAPGFQPAEPGFQPADAGGPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD20</accession>
    <name>A0A011AD20_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.987"/>
    <dbReference type="HOGENOM" id="CLU_349756_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="805" mass="85091" checksum="2BECB1603193FA0A" modified="2014-06-11" version="1">MLSPGSRLATYEVRKRLAVGGMGEVYLCRHRLLDRDDAVKVLRPHLVADQAFRRRFLREALSAARLRHPHIVTVYTADEVDNQLYLAMEYIPGADLAAILDHEQVLEPRRAVRLLDQVADALDAAHRLQMTHRDVKPSNVLVERPGSPDLQPGGPHGGPEHAYLVDFGLSKSAQQMDQDITMTGQVLGTVAYIAPEQLQGATTDGRTDQYSLGCMTFEILTGQLPFARDNQVATITAHLTTPPPLLTTLQPDLPTAVDRVVARAMAKSPEERFATCKEFVDALRSAVETGETTVVQKPPPRLDRRTPSGAEARQEQAWANPANQGAAVVADSLGDQAPLRIAARRPVDRTPPPPPSGPVGAVEPPPVVTPSAEPEAPAVPGDPAAPPGFTLPDDTPFGLPPLHDLPPDRSAGNPYTRPGAPPSGIVGRTPAPSSGVPLSGPAPTSGGGYRSYPAGAPLPSGPTPAGRTLDSRLYLAVVGGPDAGRLVPLPDGERKVPIGRVTLGFTVSGWTVQVAGETDSQVNGEPLHGVRQLTPGDLLTAGTALMEVRSARHLARLAPNSPPPDPVTLDRVARDRLAGAVRGPQHPQALVTRIGWLARRPPVPIAVPVGNAGGIAIRGPLPAAVPLARWLITQAAVLHDARDLSIAVAAGVTDDERWAWVQSLPHARPATPPLAGPHVAPTRDAALDLTSRLRQLVEVRRAAAADPRARQLLSLPRVLAVLDDRLGGPDAEFVTAVGGNLGVHVVRLLPPEARPPASCRLCIDLDPSGQTLTVWVAGRNGAQKGVPDGVSAQYAHEVAELLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADA9</accession>
    <name>A0A011ADA9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">CryarDRAFT_1101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848811.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1083"/>
    <dbReference type="HOGENOM" id="CLU_114342_2_1_11"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="12232" checksum="C20BF48535DD9D91" modified="2014-06-11" version="1">MTVLLVALGAAVGAPLRYLTDRTIQARHGTTFPWGTLVVNVVGSLILGFLAGLPASPAVTALAGTGFCGALTTYSTFSYDTYRLTRGGEPFAALLYVVASLCAGVGAAAIGLVAALAIDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AED1</accession>
    <name>A0A011AED1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849248.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783647_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="15487" checksum="8F64BD154F8455B8" modified="2014-06-11" version="1">MAADFEYFVASPDRIASLDLGRSPASQLPSATAADLPGVDPALVLLALVEVLSTEEYEALLAKGPGEVVHDGGDAGPWVIAIDDFVVAAIQGADGDPEMEWDDAVALWSGLTELDEGTLLETTDELRRLCGHVDAEHRLYCWAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEJ2</accession>
    <name>A0A011AEJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083573_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="220" mass="23318" checksum="7A524B8BA1909F41" modified="2014-06-11" version="1">MVNMIESLAHRVLTSASVVAVTRLGSAVHEVTLEAPEFGTWRCVPGQSVRLFVGNGLRTYSVWTLSGSTLVLRGFSHADGPGSRWMASAQVGSRVALTAPKGVFVLDPAAPWHLFVGDDTGAVPLLAMRASLPASASVLGIVVSREEIPPLGAPLPWRSSGTLLDAVRSLELPSSPGVAYVAGEQKACLAVRDHLRTSLGWPRRSVRVSAHWTPGKRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFB3</accession>
    <name>A0A011AFB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849740.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1768"/>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="30544" checksum="AA18B6914733D9D2" modified="2014-06-11" version="1">MSTIERVGVVGAGLMGSGIAEVSARAGLDVTVVEVDAGALEAGQRRIGHSFDRGVKAGKISAADRDAAVGRIRFTTTLDDLADRDLVVEAVAEVEALKLDVFAQLDKIVTRPDAIFASNTSSIPIMKLAMATARPTQVIGVHFFNPAPVLKLVEIIPSLLSSDETRERVEELATDRLGKTVVRSQDRAGFVVNALLIPYLLSAIRMFESGFASADDIDNGMVLGANHPMGPLRLIDLIGLDTTKSVAESMYEEFKEPLYSPPPLLLRMVDAGLLGKKSGRGFYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFR3</accession>
    <name>A0A011AFR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1925"/>
    <dbReference type="HOGENOM" id="CLU_054944_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35396" checksum="03A615572C4E8E3C" modified="2014-06-11" version="1">MSAPTALTSISASSELAPFTPATLFTAANLDQWMAIALVAAAGLYLYGVHKLRARGDRWPIGRTLAFVPGGLGIVAVATLSGLGTYDDTLFSAHMIQHMLLSMVGPILMALGAPVTLALRTLPAKPKSWLLKFLHSRYFRLISHPLIAFTFFIATPYALYLSGWYPATLTSTWLHEFTHVHFMVVGSLFFWPLIGLDPLPGRWPYPARALMMIISMPLHAVLGVIIMQMAGRIATAYYEGLNLSWISPEMDQQVGGGLLWASGDLISLLMLAAFVTQWIRSDERTAARIDRQLDRTTGEDNALEAYNAHLARLAGRPVTDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG44</accession>
    <name>A0A011AG44_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850142.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2408305_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="92" mass="9693" checksum="F1FCD4A4D369BDA3" modified="2014-06-11" version="1">MNPLARARHHRRPRWIASGFFWGVLVLADLAILSLWVTLGTLLLGVVFAGGFLLRRRRLLAAGAAPVVLSPAGTPLEAPPAGIVPPTPGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH97</accession>
    <name>A0A011AH97_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2461"/>
    <dbReference type="HOGENOM" id="CLU_459854_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="593" mass="55454" checksum="2D6069A5C33AA560" modified="2014-06-11" version="1">MQEALKTYLALATGLADVPKKQAKAAAKKLAKSGGATVEQVQALTEDLLKTSLENREALTNLVRAEIEKSLNRVGLATADEVGQLTARIKELEAALKAAQGGAGTSAGGPQGDPLADAAAGKKAPAKAPVKVPAKAPAKVAVKKVAAKKVAPVPAVKAVTPSVAKAAAKATSASESTSGTQGDALASAVKSAPAKTAKATAAKSVPAKKAPAKEAPVPAPAKSAPAKSAPAKSAPAKSTPAKSAPVKATPATATTTAATTPAAAPAATAAPSVSASPAGAVTPATTAPATTTPAKTAPATKAAKASAAKATPAKSTAAKSTPAKAAPAKAAPASTPTSTPTSTSASTTPAKTAPGKSASAKATPAKSAPAKSAAAKSAPAKTAPAKTAPAKPAFASAPADSATGTSATGASPTGAPATGTGTTGTGTPATGTGAPATGAPVTGASGASTPAVEATPATTPPATTTPAKTAPATKAAKAAAAKTTPAKTTTPAKTTPAKTTPAKTTSAKATAAKSAPAKTTAAKSTPSTTSAAKTTAAKATPAKSTPNGTAAKSTAAKNTAAKATPAKSTGNTDTNNATGPTGNAAPAGGSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIK0</accession>
    <name>A0A011AIK0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU, regulator of sigma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570208.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2913"/>
    <dbReference type="HOGENOM" id="CLU_000445_43_8_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="298"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="57427" checksum="A6AAC76EF37984EC" modified="2014-06-11" version="1">MRDLFDAAGALRDAYRGVDWAATPLGPVESWSPTLRSTVDLALNSRFPVTLLWGPTYVLVYNEAYVQLIGDKHPGALGRSAIDVFGEIWDTIGPLLDSVATGRGTTWAENQLLMMDRHGFAEETYFTYSYSAVYGPDDTIEGVIDIASETTHELVDRRRLALLSRLSDRLGHLEHPQELDAVALGVLRESPADFPDVAIRVPGSLPPGQDFALEPGPVAHLRLSTEPDATFVARLSPHLPLDERYLGFVRLIGTALSQALSRARQRDAERRTAELERRMSESLQRSLLTPPPKPDGLDIAVRYRSALEQAQVGGDWYDAFELPDGRLTMAVGDVTGHDMDAAALMGQLRNLLRGISYTLRHFPSRVLAALDDALHGLHVGAFATVVLAHVEREGPQGRREVRWTNAGHPPPALVTADGTVTLLYTRPELLIGVHPNAARSDHTIVLEPGSSLVFYTDGLVERRGQSLDDGLGRLVDTLAGRPHRTADELCDHLLEAFGPTSEDDVVLAVLRVHTLEQWTNSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKM7</accession>
    <name>A0A011AKM7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570567.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3682"/>
    <dbReference type="HOGENOM" id="CLU_008084_2_1_11"/>
    <dbReference type="OrthoDB" id="326558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="558" mass="60950" checksum="1D557C29912E1D77" modified="2014-06-11" version="1">MSTDNARAAAEDSLEDYAFRYVPRTFRRWSAASVGATALGSIAFLADFSIGASIGIDHGTANAVLGILFASVVIVIVGVPVAYYAARYNLDLDLIARGSGFGYYGSIITTMVFAGFTCIFFALEGAIMAQGLQVATEMPLWLGYLLSTVVVIPIVIYGMRALERLQFWTTPLWLALALLPLLWILVSDPEAVRAFTTFTGNSDGSIRFGAVVSSAAVCFALTPQLAEQIDYLRAMPPRTSSNTRSWWTSFAFAGPGWVVFSGTKQVIGVFLAVYLLVKVEPTLGHRATEPVQQFVVMYQTLVPDWLAIVLALVLIVVAQVKINVTNAYSGSLAWSNVFTRMAKHYPGRTIFVLFNLVIAYALMMLDVFTLISFVLSLYANVVMAWLVTIAADIAINKWILRISPRFPEFRRGMLHDWNPVGLVSVGLASALSLLAFAGLFGPGVKPFSVLIAIGVAMVATPVTALATRGRYYLRRRSDGIDSPRFDDDGNPSGERLRCHVTGYTFERPDMLASAERGPHGEVQYVSSLALTLDDSDRFVLPPEVTEPPRWAAARSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKW5</accession>
    <name>A0A011AKW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3768"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23436" checksum="6E9402364CE90157" modified="2014-06-11" version="1">MRIVIAEDSVLLRAGLVTLLAGAGIEVVAEVGDDEGLLRAVERHRPDLALVDVRMPPTHTDEGVRAALALKARWPDVAVLLLSQYVEERYAADLLAGHTGGLGYLLKDRVADVDEFIEALRRVAAGGTALDPEVVAQLLVRRRTSPVRQLTPRETDVLATMAEGRSNSAIAATLGIGGHAVEKHVNNIFAKLGLVPADTDHRRVLAVLRYLERGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALG0</accession>
    <name>A0A011ALG0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852676.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3917"/>
    <dbReference type="HOGENOM" id="CLU_031365_0_1_11"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="327" mass="35303" checksum="C30662644A141344" modified="2014-06-11" version="1">MTVTEAPATNADAPAAGHHPRRRWALLAAGLLAALALPWFVYPPVAMDIVAMALFAIALDILLGYTGLLSFGHAAFWGSSAYVTGLIATHYGVPFPLAIVGGAVFAMILALPLGYLSVRRSGIYFAMVTLAFAQLVYFVGYQWSDLTGGENGLQGVPRAFFGLELVETNSFYFYYAALPILLLGMWAAWRIVHSPFGRVLVSIRDNSQRARALGYEVEKYKVVAFVLSAGLTGLAGGVFAINHGFVALTELHWSTSGEVVLMTVLGGIGTLWGGILGAFLVVMLADYLASSGFHGIDLVTGSVFVVVVLLFRRGIWGTVRHRWRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFK7</accession>
    <name>A0A010YFK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847357.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.27"/>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_11"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="23413" checksum="890BAA953577D95E" modified="2014-06-11" version="1">MSPRILVVDNYDSFVYNLVQYLGQLGAECVVRRNDAVRPAEVLDGDVDGAPVDGVLLSPGPGAPEEAGVCIGMVEQLAGRVPLFGVCLGHQAIGVAYGATVNRAPELLHGKTSEVHHADAGVLAGLPDPFTATRYHSLAVVEDTLPAEIEITGRTPSGVVMAMRHRELAIEGVQFHPESVLTQGGHRMLANWLGTCGDEGAVDRSTALVEQVEQRRLAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFN7</accession>
    <name>A0A010YFN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847435.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738421_0_0_11"/>
    <dbReference type="OrthoDB" id="1795668at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16199" checksum="C481EC1387349296" modified="2014-06-11" version="1">MAHIDMSVATAEVASDVVPTLRLVDGIRPLENWLHSVSEAEEPCLLLDGDGVVLAASSSCHGALGLPSHEGALVGRGLLEDIVELIDFSASRIRLRPDEVERIPPLLALSTGALARGLMRLRSGSTTWTLDAISTPIRVGGAVLGSLTFFHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHU6</accession>
    <name>A0A010YHU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="16084" checksum="84094D36F66D7B98" modified="2014-06-11" version="1">MALLSGELAALLHDVSRQLRAAAHAEVNLVPLPESERDVLRFVGRHPGVSVSTVARELRMKSSNVSAAVRNLVARDLMTRDADPHDRRIARLTLTGQAYDNLERLQRAWNTHLDAALSRVEPGYREQLEGAVPALRALVQVLRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIZ8</accession>
    <name>A0A010YIZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569824.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1252"/>
    <dbReference type="HOGENOM" id="CLU_707531_0_0_11"/>
    <dbReference type="OrthoDB" id="674527at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="181"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="44216" checksum="D894DE4FB017E240" modified="2014-06-11" version="1">MLDELLDELDARLADTDEALTAQHERTAPGRQPVHTVYVPADRFTAGLPARWGAEALTLLDEHGSSPEAFGLPAEAVSGALPRVRVKLAAEPIEDLRVDFEDGYGYRPDADEDADAQKAGQALAALAGREGAPFTLGLRVKSMEARDRRRGVRTLDLVVGALVGARPDGPELPPVIPGEFVVTLPKVSSVAQVEAMLSVIDAIEAGNRLTAGTVRLELQIELPSAIQGPDGVATVANLVRAAGTRCAGVHYGTYDYSAALGVAAAFQTLEHPVADHAKAVMLLAAVQAGVPAVDGSTNVMPTGTADEVRAAWANHARLVRRSLERAYYQGWDMHPGHLVTRYLATYVFFRDALPAAVTRLTTYLGRSSEGSSVVDEPATARALSAVILRGLDCGAFTDDEVPLDVPALRRLSRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJN9</accession>
    <name>A0A010YJN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861232.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_5_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="126" mass="14597" checksum="E8D841369E28F213" modified="2014-06-11" version="1">MRSIGEVSNACGVSQHLLRQWEDAGLLSPQRSRGQRRYSDLDVRLVRFIQRGRELGMGLGELREMFAIRDVAERTAVLQRRKKLLEDRIALAQQELAFVERGLECPHPDYRTCPDLAEIVQQPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKA4</accession>
    <name>A0A010YKA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1719"/>
    <dbReference type="HOGENOM" id="CLU_038683_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="41775" checksum="257E32CCFB4B4900" modified="2014-06-11" version="1">MRTRHHLGFWLIAGAFLTAMAFSTVPTPLYVLYQRRDGFSSFVVTVVFATYAVGVVISLLLAGHISDRVGRKRVLLPALGLELLAALIFLSSAGLPELLLARFVSGLGVGMIAATATAYLSELHALSRPGDGTGRFEMVSTAANIGGLGVGPLVAGALAQYLPAPLHTPYLLFAVLLVLAIIGVGFTKETVDLSSERPAWRPQRIGITGTDRRAYLAAAVTAFTAFAVFGLFNSLAPGFVAGTLHHPSRLLAGVVVFVVFGAAATAQTLTSGLRPAARFGLGVSVEALGLLVLVAGMATGNLAGFLVGGALAGAGSGVVFKSAIGAVISSAAPAARGEALAGLFLIGYLGLIVPSLALGVTTRFVDATTAMYWFTGALLFLLATGAWLHGAESPRRLVTTSGSVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKC0</accession>
    <name>A0A010YKC0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="4">G6PD</shortName>
            <ecNumber evidence="4">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zwf</name>
        <name evidence="7" type="ORF">CryarDRAFT_1767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849692.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1735"/>
    <dbReference type="HOGENOM" id="CLU_013524_5_1_11"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="5">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="6">
        <location>
            <begin position="198"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="499" mass="55388" checksum="9888A43FF20BA64A" modified="2014-06-11" version="1">MDIGPHYSNDRSAPPSTLVIFGASGDLTRRKLIPAVASLARHGRLPQEFALVGVARTPMSDEQFQESILGGNGLGDLQQLAGGGLRYVSGGYDDPETYKTLATLLDELDQQRGTRGNHLFYLSTPPQAFSPIINGLALAGLNRARTEEGFSRLVIEKPYGSDLNSARQLDATVHSAFEEPQVFRIDHYLGKDTVQNVLALRFANSIFQPIWDRSWVDSVQITVAETLGVGTRGSFYETAGAMRDIVQNHVLQVLALALMEPPASFGAEALRNEKVKLLQAIRLPTDRDVADVAVRGQYTRGGTREELMAGYRDEQGVDPLSRTETYAALRLDVDNWRWAGVPFYVRTGKRLPARVTEVALTFQRPPHLPIPGNQLTELEADALILRIQPNEGISLRFGAKVPGHSFRVRTASMDFSYDQTFQEESPEAYERLILDALLGDATLFIRTDEVEQCWRIVDPIIEHWANDKSPIPTYEAASWGPSDADRLIGRHGRAWRNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKU3</accession>
    <name>A0A010YKU3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1904"/>
    <dbReference type="HOGENOM" id="CLU_469876_0_0_11"/>
    <dbReference type="OrthoDB" id="2088281at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="580" mass="57928" checksum="9EA5A6B12448C642" modified="2014-06-11" version="1">MTEPNIPARPDPLSREKAPDVSSASASSASSPPGGARRGDAEPSTASGVPALEEPTTRGIDSLELPPLPPLASSDSAPVGHSLKTPGAASPAATPTADEPLPSAAPSAKPVSPARPTSEAKPTTEAKPTSEPKPTSEPESATEAKPATGPKPTSEAKPAPEAKPEPAVNGVRSAVPRPASGAPGVGHSPRPGGSASVPAFNDSGFRTAAAAATGGALSTGYRGYAAHATPTSSLSTPASQVPPALRGPEAPEEKDDKKKGFLGISGGQVLAGAMAASTSAVAASYLGVAGTVLGAGLGSVIATVSTAVYQKSIQRSGKVLQTVVTTTVGGQQVPVDEVLHEGRDSSTVAPDPSLPGVEQVGRGLPDPSLTPAPHHAETHVMSAVPDDATRPFGVPPEPQGPLYGSAPVPPPSRPDDSGTVYGGGPPWYSELPWKRIALTSAALFVLVMGVITTVEMIEGRSLANTVKGEEGRGTTITQPFQQKNDEPDTSPTPSPSESGSESATPSESPSEDLSPSDEDSESPSGEPTESTDSTPSDAPNDESSPQPDPIQTQGTDLTSSAPGAPMTDAATTVPSASPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLP6</accession>
    <name>A0A010YLP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioester reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2215"/>
    <dbReference type="HOGENOM" id="CLU_009549_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="644"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1152" mass="123865" checksum="3758B28563661B61" modified="2014-06-11" version="1">MTHTDQGDVTTVAERRALLLEQDEQFASAVPDDHVTALVRQPTMSLEAVVATVMAGYAQRPAYGERATEAVLDPATGRTTRRLLPRFDTVSYGELWRRAGALAAAWHHDEHEPIRPGEFVATLGSTGGDYATVELALIRVGAVGVPLPGGSAPGQLLPLVHETAPRVLAVDVEHLGTAADIVESGTSVRRLVVFAHHADVDDERERIDALRERVAGHGVVVETLPEVLGRGAALPPAPSPPADDDRLALVIYTSGTTGSPKGAMYTARLIAELWRGFFPERPGLPLIDVGFLPMSHLAGRAVLFSTLARGGTTFFVARSDLSTLFDDFALVRPTVLLLVPRICEAISQQYQLLADDRADEREAGRVLREDVLGGRVLWAVCGSAPLSAQLAALVSSVLGTKLSDGYASTEAGAVLFDGRVMREHVLDYRLEDVPDLHYFGTDRPHPRGELLIRSATLFPGYYHRPDATAEVFTADGFFRTGDIVAEVGPDELVYLDRRKNLLKLSQGEFVAIAHLEAVFAAGPVIQQIYLYGNSERSYLLAVVVPTAEVLTRTGGDPERVAALVRDSLRETGRVEGLEGYEIPRDFLLETEPFTTGNGLLSGVRKLVRSKLQERYGGRLERRYEELARHESDEIRRLRSDGPRQPALDTVLTAARAVLSAPADDLDPAARFADLGGDSVSAVRLSALLGEVYGFAVPVAEIISPVNDLKALATSIERHRGEGGGRPTAVTVHGAGATEVRAGDLTLDQFLGPDVTRTPAPPADVPRTVLLTGANGYLGRFLALEWLRRLHPVGGKLVCVIRAGDDAAARARLDAAFGAADTEASRQYRTYADATLTVVAGDLGEPRFGLGAGAWRELAENVDVVVHAGALVNHVLPYSQLFAPNVLGTAEVIRLAVTGKLKPVTYVSTVGVVTGSEPESADIRVTDPVRRLDEGYANGYTTSKWAGEVLLREAHDTYGLPVATFRPGLVLAHRRYPGQLNVPDMFTRLLLSVAMTGLAPRSFPPLATPAHYGGLPVDFVAEFIAALGAGPAPGFETYNMMSPQPAGSSLDTYVDWLAGAGYPITRIDDYGEWLERFEAALRGLPRPRRQQSLLPLLPAFAVTTGPVAAPPVSTDHFRDAVRKAGSGVKGEVPPVTAELIRKYLADLTRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM85</accession>
    <name>A0A010YM85_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2389"/>
    <dbReference type="HOGENOM" id="CLU_017985_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="96"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="487" mass="51667" checksum="3E49C11EFFB2F915" modified="2014-06-11" version="1">MSRFARWLSAGAAGGADRVGTVETESLFDGLAEDPAAPVAPPPRPARIAGAVDADRVDPHAPLAVRMRPRTLDELVGQRHLLAPGSPLRRLVEGDAPLSVILWGPPGAGKTTIAHLVSRATSRRFVALSALSAGVKDVRAVIEQAKLERRRGVYTVLFVDEVHRFSKTQQDSLLAAVEDRTVTLVAATTENPSFSVVAPLLSRSLLLTLMPLDADDIRELLHRAVTDERGLGGAVTLAPEAEDHLVRLAAGDARRSLTALEAAADAALAAARADIDLATAEAAVDKAAVRYDRDGDAHYDVTSAFIKSMRGSDVDAALHWLARMLTAGEDPRFIARRLMIFASEDIGMADPTALQTAVAAAQTVQLIGLPEGQLTLAHAVVHCATAPKSNAVTTAISAALGDVAAGKTGTVPPALRDAHYPGAKALGHGQGYRYPHDDPAGVVAQQYVPDELVGRDYYRPTRRGVERPIAERLDRIRSVIRGKTDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMI3</accession>
    <name>A0A010YMI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850765.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2510"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="35744" checksum="87069EFE811D54A4" modified="2014-06-11" version="1">MMTEIVLPGIVEPDGLVVSRRPLPEPGPGQVRLGVEASGVSFAEQQMRRGKYYDQPPFPFVPGYDAVGTVHATGPGVDPALRGRRFAALIKVGGWASDAIVDEGDLVPVPDGVDAAAAETVVVNGVTAWQMLHRHAKVRPGGTILVHGANGGVGSTLVQLARHAGIRVLGTASARNHDAVRTLGAEPIDYRSDVPARVRELAPDGVDAVFDHIGGKSVRDSYRLLAKGGALIAYGTASTKNDPGNSQLPVLRLFARLAWWNVLPNGHHTMFYNIWTGRRSRAAFQARLREDLTQVLRLLADGAITAQVAARVPLAKASDALRLAESGTVTGKVVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMK5</accession>
    <name>A0A010YMK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CryarDRAFT_2569</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570084.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_6_0_11"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG81455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="225" mass="24330" checksum="8B8C3CE3735A6C8E" modified="2014-06-11" version="1">MPFDLPILYAHAAVEWGSALLTPLAGSAATAVAIVLATLGVRLLLLPLTFRQIAVERRRAALAPRVQKLRDRHADDPLRALTEVSALYRDEGVGTLTTMGPLVLQAPFFLTLFSLFRLPTVGGAPNGLLGHELGGVPLGDHWLDGSLLGVHSVVFVVLFGLFLVLATVGARRLRRLGQPAWLGFAPYVSVVFAITVPLAAVLYLLTSTLWTTLENAVLRDRLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMN3</accession>
    <name>A0A010YMN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850819.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_2_2_11"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="22648" checksum="44421D9D4AD66202" modified="2014-06-11" version="1">MHLELLTSPVVYPLVFVLTLLDGFAPVVPSESAVIAASSFAVSGRPVLLVVVLVAAVGAFVGDHIAYGIGRLLLGRGTTAAGGGRPRRLGRLGRWLASLAERAAGSLGSGAGVVILTGRFIPCGRLAVTLACGAGRYPLRRFSAWTALATAAWATVTALLGYVGGVAFAQTPWLGMIAGLSLGLVVSGVLAAVSRRRRTGGRTAVISSSAVRTAADRCLRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YND3</accession>
    <name>A0A010YND3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851112.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2772"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="261" mass="26829" checksum="20F53AC92B385DC4" modified="2014-06-11" version="1">MILDRFRLDGKVAVVTGAGRGIGAATALALAEAGADVLISARTEDDLRAVADRIATTGRKAVIAAADLSDADAAASLAERAVDAFGHLDIVVNNVGGEMPRPLLKTSVRRLESAFHFNVSTAHALTTAAVPALLETNGAIVNISSVMGRLPARGYAAYGTAKAALAHYTRIAAADLAPRVRVNAIAVGSIATSALELVLDNDELRTTMEQNTPLKRIGDAEDIAAAVVYLSSPAGAYVTGAILQVDGGLRTPNLDLGLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP69</accession>
    <name>A0A010YP69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570257.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3072"/>
    <dbReference type="HOGENOM" id="CLU_727500_0_0_11"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="40164" checksum="81B211CDEB372069" modified="2014-06-11" version="1">MYKHPKIAIVGGSLTGPTLALLLLRAGFDDLTLYDAAPALATRTGGVMSLENTALDVLATIGIPQREIVTGRSDTIAQITVRNRRPIKTTRIPYPGRFTTWALLHAALRARLPGSVLHLGTRIVGLHESVRGPVVVRADGSSEPADLVVFADGRNSIGRRLLDPGRQTCYSGCVAHRGTSSRPGDPSGDFRRYDLGQGGQFNLAPVPGGQDWIFGLNASPNEFRAWFGVSPGERSYVTDGQIGGSARSRLDQEAVDRLPAAEAHLVVSTRRRAAVAIMDVDPPTSMVWPIGAGYAVLLGDALAPPRPVTARGANAGIEQAAGLVQCLRHGQLGDDLRDWERHCLPDAVATLERGLLISSRLGLGTSHTIPVLDGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPR7</accession>
    <name>A0A010YPR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor, sigma-B/F/G subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_3323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3282"/>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="29959" checksum="BC2240BF33B14EAB" modified="2014-06-11" version="1">MTSGAMTVSVESDAVMDYSNYPMVEPLFRRLAALDRADPVRRQLRNEIALLHLPLARNLAYRYCRRGQQTEDLLQVARVGLIKAVDRFDPDRGVGFLPFAIPTITGDLRRFFRDTAWDVRLPRRLQELNLRINAGIVELSQRTGRAPTAGELAAHMEVPREDVIEGLQAGAAYTAKSLDVPAAASAEAPTLAESLGGDDRRFEAVDNHEALIDLLAALPAREKLILRLRFCEDMTQIQIARVIGVSQMHVSRLLAAVLDRLRTQLLAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQI4</accession>
    <name>A0A010YQI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852255.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="28009" checksum="C49980CD9280A730" modified="2014-06-11" version="1">MTAYRKPIVVGVSPTDSANDVVAWGAREAQLRGRRLRLVHAHEFAHGGTAAPATARLAYRDAAEWMRAQRAYAARLLPGGELEATVLDGNWVEVLLHQASDAEMLVVGSGDEWRTDGLATARAVQLVAHADVPVIVVRGGGQPAAAAGRVVVGCGEGDQPDVLLAAAFDEADRRGVDLLVVRSRISADVPREADVLAGWRAKYPQVVAGLRVCHESPAAALIEASQAAGLVIVGSRGAGGFPGLRLGSVTDAVLRHAVCPVLVVPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQN5</accession>
    <name>A0A010YQN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852369.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="39523" checksum="4DE9A1CA5B695F19" modified="2014-06-11" version="1">MSGSPSALRFLNDRAALEALLQHEAITRAQLETLVGLSKPATSQLLARLEKVGLVERLGRREVGPGPRAQLWGLKADAGFAAGVDVTSQGIDVEIADLRGTTVAQHRAPAATDEPAAALGAALGEACRRAGLGVDRLAHVAIGTPGSVDAASGVLRYASDLPAAWTRVNLLQAIGSVLDVPFTIENDVNLVALNEMARGSARDVRDFVLLWISEHGVGSSVVVHGGLVRGATLGAGELGFTPVPDLAREPLPGVHRFGDLLAGSALLTLAGTHGLTAGGPIDAIRQSLEGDDGFLIDVARRIAAGLAAVVSLLDPELIVLGGAVCSAGGSALRAAISEALAEFVEPRVRLVPGRPDSDSVRAGAVQAALVPAREHYFSAGSSLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRY6</accession>
    <name>A0A010YRY6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4156"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29363" checksum="193028B0D51F9D57" modified="2014-06-11" version="1">MMRRIGIFLVVVWSVLPIYWAFKTSIQTEGDARDGQYLPLHPTLDNYTSLLSGDSDTANGIRSSLLNIVIECGAATIVTVVLAALAAYAFARMTFRGHTILFYGVLLTMAFPAYTTLIPLYRIMSEAYLVNTYTGVVLVYVSGFLPLATWVLHNYFSGLPSSIEEAGLIDGANRLQVFWHLVLPLARPGIISTALITFLFAWAQFLFPLVLTTDTSTQPLTVVIASLQGRHVVPTTLLSAAGMIAIAVPAVVALVFNRYIVNGLLAGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVV7</accession>
    <name>A0A010YVV7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_169_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="624" mass="64576" checksum="6C4544204B7B919C" modified="2014-06-11" version="1">MARQLTTHHSRELGTVVHVRSEASGTQPASPVAGLSDLTVLARGGYSTVYRARQDSIGREVALKIDTRALQSERDRRRFVREAESAGRMSGHPNVVNIYDAGVTEDNHPYLVMELCTGGSYATRLRQHGPLSPVEVRDVGVKIADALQAAHDNGILHRDVKPGNILINRYGVPGLADFGLAALPDPSRELSVTIEALTPAYAPPEVFRMEPPSPLGDQYALGASLYALLSGRPPRWPETGTPSLATMVMMLDEPIPDIPGIPANLSAVLRQAMAPYAEDRYPTVGELRDALAALDLDSDTGSRHGAFGGTPPVTPSSGGPSGGRPSSGGPSFGAPSYGPPSSGGGSYSAPGAGWQQAPPTGPPMGGQPPTSAFSSSPFSPVQQVSGGSGGKPAGGPPYGPPPHGFHAPQPTKEGLSPQTKRLMVMIIAVAVALLICGVVGSALLAVVGDSDTTTDYEPVPEETTGPAPTDATPVPSPTRSGELPGFPLDGLPSATGTVGAFGSVCEVAVVAASGTSAQASCPAKPECWRDRSDGGIRSRGCTNNHTWETYVIGTLASSATDAKAIRNDPNVQLLCSPTVLEAALSTTGQDTAGWRTTVSAYGATKFRCLAGKGTDELKQAYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVX6</accession>
    <name>A0A010YVX6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682799_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="403" mass="38741" checksum="E79C2E14C5A4465A" modified="2014-06-11" version="1">MLSAEPVVGPFCAEPVVGPFCAGPVGAGPFCAGPAGAGPADAGPADAGPDGRAIGAEPVGGTLGAGVVDGPRGAGMVVDGRLGAGVAARAAGAELGAAAAVLVGAARFDAGMPVAEARGVLEMGALVGAERADPGAPPAGPVDTVRPGAASLRVEPPEIELPGVELPGVELPRVEEPGAGLPDGEPPAVKPSGAEPPDAEPAGAEPLNAGPLNAGPLNAEPLDAEPLDAEPLDAEPLDAEPLDAELAEVDAPRPVASSDESGAKARARGLVGTPPSGAVIESRRDEPDRFGRSNPAADESPSALDAGLLGAGPLREDLGSDGCAGRGICGEDKNASDRIGSNVVGAAAGIAAEDGARSPDRGAGTTTRASSTPGASFALRASAVPCATSASRAMSAPCAPSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWP2</accession>
    <name>A0A010YWP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_0_1_11"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18205" checksum="32F77A4F992AB36B" modified="2014-06-11" version="1">MTPMPNLPSRSTFPVLRDVPTRWHDNDHYGHVNNVVYYAYFDTAVNGWLMDATDADIRDLPALGLVVETSCRFHRSISFPDRLEVGIGVAKLGTSSVVYRLAIFRKGDDDAVALGRFVHVYVDRATRRTSAIPPVLRDVLAPVAEKSAPLFQAAGLLDAEEGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWU0</accession>
    <name>A0A010YWU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848389.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.655"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1109" mass="118070" checksum="73677EC2E302FDCE" modified="2014-06-11" version="1">MVRVSVLGTLRAEVADQPVELGGPRQRAVLARLVGARGHVVSTERFVDDLWQGEPPPKALAALQVYVSHLRRALEPGRAPRTPARVLVSAAPGYALRLDDDAIDAWRFERLLERAAGAPAAEAADLLDQALAQWSGPAYAEFADEAWAVPEAERLEELRRVAVERRAGAMLATGRDAEVAADLDRHVRAHPLREDAVALLALALYRTGRQADALSVLRDARTRLADDLGVDPGPALRALESNVLAQSPTLELIVERPAAAPSESAVAAPAPSSGVIVGRRAELARLSAAAERAAGGEFRVTWVGGDPGAGKSTLAGAVADRLAERGWQVLRGRCPEVDGAPPAWAWSEVVHATIDRVDDALTARLGPLLHQEAAAAPARDVPPFWLGRAVAELLTTLTTAGPLLVVLDDVHRADGETLQLLRHVASELVGRPVLVVATYRPAEVTDDLSACWAALAGSAADRVDLAGLSADDVAELLRRQGAPTDTALVQLVTARTGGNPLFVCETARLIAAEGPDAAATSVPTGVRDVLRRRLARLPGPARAVLRTASVLGVEVDVDVLLALENTDEDTVLDALEAGVLTGLLVEPSTGAVRFAHALVRDTLYEDVPRLRRTRTHGRAVEALARVRPGDRAGLAHHALAAATPATAVRAASLAADAARSASALFAHQEAATLLRRALDVLDQADARVEPGFRLDLLCSLVSAQGYAGNVIEARVTRVRAIAVAGEVGTIAALAQAYASFDAPVIWSVRENRSVDRPFVDGLEAVLRDLPPAEVERRAQLLATLTVEIEGVDAGLAARSSDESLAIARGLDDPELLCRVLSARYYVDVAPDSRHRLGELGAELRETAVRAGLTGYRAQSHHILFQHALSRPYLDDLEPAQYEADRAVEYSDTGQLGLALGVVRMFRGLRALVAGRFDEAADAYAAVIAQMRQIGAPNATGVEQLTFYAVGRARNDEAQLLGLVEPIGALHAQEPHLTSEPYTRLLLHAGRVDDARAVWQPTSAIPPDYYWLLWMAFRAENALGLGHTEVAADCYRALLPYAGTLPGLASGSITLGPTAGILGDLAAFLGEPDTAREHHRDALRVAELLGAPHWAEAARERLRWPPPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWY0</accession>
    <name>A0A010YWY0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848441.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.692"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="215" mass="23215" checksum="775189F1FF53FEF4" modified="2014-06-11" version="1">MIRVLIADDQALVRLGLRALLDNEPDLEVVGDVADGLAAVAVAVETRPDVVLMDIRMPGIDGIEATRRIVAAVPDTRIVVLTTFEIDEYIFDALRVGASGFLLKDTRPTDLLDAVRGVVAGGALLSPSVTRRVVKTFVDRPSRRSEPHPRWSSLTEREQEIAALVAEGLSNDEIADRLVISPATVRTHVGRAMVKLGARDRAQLVVFTYQSGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXB7</accession>
    <name>A0A010YXB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848592.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.843"/>
    <dbReference type="HOGENOM" id="CLU_041141_1_0_11"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="325" mass="35745" checksum="823CF07BFEEE132C" modified="2014-06-11" version="1">MANTSERTLRLLSLLQTHRYWPGGDLADRLGVSERTLRRDVDRLRELGYPVDASRGVAGGYQLRSGTAMPPLLLDDEEAVAIAVGLRTAAGGAVEGIEETSVRALTKVIQVMPPRLRRRVEALRAYTVPGVFSGGPTVDAGALAVIASACRDDERLRFSYTARGAERTSRLVEPHRLVSMGRRWYLVAWDVERGDWRTFRVDRLSSPQPTGARFRQRELPAEDAAAFVRQRQAERPHRYTIEVLVHAPEAAIRSAFGREADVSVVDAGSCRVVIRSDYLEWPVASLGWLGADFEVVGPPEFIDALRATGERYARAASGPAGVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXU5</accession>
    <name>A0A010YXU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848787.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2698422_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="73" mass="7415" checksum="A0787B78117FF07F" modified="2014-06-11" version="1">MPNLYADAAGTHPLSAEPIPVSPDDLVAWVHDLLAGRGLAPALTPETRDAAEHAAALLLGALGVATPDADHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ49</accession>
    <name>A0A010YZ49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type metal ion transport system, periplasmic component/surface adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849423.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1555"/>
    <dbReference type="HOGENOM" id="CLU_016838_0_0_11"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458214" evidence="1">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="32124" checksum="885800E6DEF96FED" modified="2014-06-11" version="1">MVASRSRWTLGAVGLATVATLVAGCGSSDDGATTAASDGAKSTQVVASTNVYGDIVKQIAGDSSKVEITSIISDPSQDPHSYEANTQTQLKLSKADLVIENGGGYDDFMDTMLKSANNGDATVLNAVEVSGKTAPADGELNEHVWYDLPSIEKLVPKITEALSAADTSEKATFEANAKTFLGKVQQLESAAAAIKAKHNGEGAAITEPVPVYLLQASGLVDKTPEEFSEAVEEGTDVPAAVLQETLGLFTAKQVKVLAYNEQTAGPESDKVVAAAKSAGVPVVAVTETLPPGKDYVSWMSGMLSSLQTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZE4</accession>
    <name>A0A010YZE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="33311" checksum="7A0ADF7836214429" modified="2014-06-11" version="1">MVGRQLAVFGIAVAALGCVVVLSLMVGRQSIALVNAVRALLPGAHGEIADIVRGLRLERTVVGVVVGLALGGAGALMQALTRNPLADPGLLGVNAGAAAVIVTGFTFFGITSGYPQVWLALAGAAIGSVAVYLLGGGGRAATTPARLALAGAALTAVLFAYMNGLAMRDQDTFDEMRFWVVGSVVNRGYDGLVAALPFIATGAVVALLVAPALNALALGEDTSRALGLGVGRTRALTGVAITLLCGGATAVAGPIVFIGLTVPHVARWLVGADQRRAVPLSMVLAAFFLVLCDTLGRVVSGGAEIQAGLVAAIFGAPIFIALVRRRMLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z015</accession>
    <name>A0A010Z015_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">CryarDRAFT_1863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849846.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1830"/>
    <dbReference type="HOGENOM" id="CLU_108696_5_6_11"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="81" mass="8660" checksum="FB3E83ED3C406014" modified="2014-06-11" version="1">MSSNDEIRAGLAEILEEIADVQKDDVADDKSFTDDLDVDSLSMVEVVVAAEEKFGVKIPDDDVQGLKTVGDAVAYISQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0N4</accession>
    <name>A0A010Z0N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/amide ABC transporter membrane protein 2, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725695.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2077"/>
    <dbReference type="HOGENOM" id="CLU_031365_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="35875" checksum="2ED28EF33FF30C6F" modified="2014-06-11" version="1">MNRLVGIGFLVVTMSLPLVLDDTRLSIYVLMGLAVLAVTGISLLMGYAGQVSLGQAAFYGIGAYTAAVPAVHGWPPIVGLLAAPLVAAGAAALLGALLLRLRGHYLAFATLALQLIILSVAAEIEFFGGAIGLQGIPQFGIGSVTLDEPREYAWLTWAAVALVLLLTANIVASRPGRALRALAGSEQAAAASGVPVIRYKVTVFALSAAFAGLAGGIYAFFLGYIAPGSFTIAMSVEWVVMAVFGGLGTRWGPVVGTVAVTLVVQVLNDLSTRPGAPSYAPTVLGYAAYAVLLIGVLLFMPAGVVPWIGNRLRRRRKTPDEPIRMIPEWPPRREQTSRATTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z276</accession>
    <name>A0A010Z276_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570100.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2608"/>
    <dbReference type="HOGENOM" id="CLU_047691_9_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="20352" checksum="ACE66AB607D277A7" modified="2014-06-11" version="1">MTTSLRSRVRAGDPAAFGELFDTAARRVYNHAYRLLGDWSAAEDAVSLTFLEAWRCRSRVRPDGDSLVPWLLGIATNVARNTARARRRHAAALGRLPMPHDEPDFADDVADRVDVLASARSAQEALARLRRPEREVFALCVYASLDYAAAAEALGIPVGTVRSRLSRARARLRDVTVPAERVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2I7</accession>
    <name>A0A010Z2I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2718"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="36829" checksum="D7A08DE8587228BA" modified="2014-06-11" version="1">MKLRTAVPEAPTISARGGRVELVDLRKTYGGNTAVDSIDLEIEPGEFITLLGPSGSGKTTTLNMIVGFTEPTSGHVRLNGQDITRTPPNKRDFGMVFQNYALFPHLTVAQNVSFPLRERKVPAGEITRRVGEALALVDLTGLDDRRPHELSGGQQQRVALARAVVFSPSVLLLDEPLSALDRKLRQSLQREIKRLHDELGLTFVFVTHDQDEAMTLSDRIAIFDQGRIVALGTPAELYHRPPTRFVARFLGESNVFGDSIVRPERLGVVLDDAAVPPGAKTAPATVTDVSFYGTYSRIELAFGDDSVGCGVLPAGSPPAPAPGTPVIAHWRPEDQIPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2J3</accession>
    <name>A0A010Z2J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-dependent enzyme, putative carboligase or decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2723"/>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="395"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="570" mass="60252" checksum="78CE43766FA5BC40" modified="2014-06-11" version="1">MTGTGARVVADMLAGYGVTHVFGVPAILRRTLAALEAHHPHVQRVVTHGEKSAAYMADGYARVSGRPGIAMAQVVGALNLAAGLREPFLAGSPVIALTGGRSPATRFRHVYQEVDDVPAFEPVTKFNATIDDVSRFPDLLRHAFRVATTGAPGPVHLQIQGNEGQLDAEPTDVEPLVEPECARVPARRLVPADEDLLAVLRLLAAARRPVVVAGGGVRASRAGAELVALAERLGVPVATSANGKDTIPGTHPLSVGVVGTYSRECANQVVARADLVCFVGTRTGGMTTHVWTVPPIGVPAIQIDVEPSHLGRNYPLRAAVAADAKLALARMLALAGADTAGAERGAWLAEVDRRRADWRARYREVLTSDAVPVRPERIAAELTAGLPRDAVLVVDTGHAGMWMAQFHDVTSPDQGYLRSAGHLGWAFSAGLGAKCAAGDRPVVAFTGDAGLHYHLGEIETAARRGINLVTVVNNNSGGNQSKRGFDRAYDGRPTARSRELWTYRDVDFARVGTELGALGLRVDRPGDLPKALDQALHAGRPVIVDVRTDLEVVAPPPFAPQPLAPQPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z327</accession>
    <name>A0A010Z327_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851255.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2890"/>
    <dbReference type="HOGENOM" id="CLU_130420_0_0_11"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="13948" checksum="88A9D47A51640AD4" modified="2014-06-11" version="1">MATLKTTRTDASVDEFLAAVPGEARRADAHTIRALMARVTGDPGAMWGANIVGFGATPLRYASGRTVDWFRIGFSPRKAATTLYLGDTFPRKDELLAALGPHTTGASCVYVKRLDAVDPSVLEALITAAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3I6</accession>
    <name>A0A010Z3I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A/B barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570246.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2355045_0_0_11"/>
    <dbReference type="OrthoDB" id="1584631at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="109" mass="12088" checksum="200065C0E10CD5A5" modified="2014-06-11" version="1">MTDQRMTSPEEIVHIVLVEWRAGSIGVSEEANRLVDRHLGPLPFVLDVRSGASVSTEGLENGFEWALVIRFADRAGLEAYLPHPEHRVVAEFLGARAGRLVVFDLPNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3N1</accession>
    <name>A0A010Z3N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1871983_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="14382" checksum="32BA91726839A531" modified="2014-06-11" version="1">MAETDVLDGVPVGVELDTGTIQLEEATLVRLIQDLAPYAVGLSDVDPGDASLATAVSRTRDILERAYGQRLTFRGEDRAETGSRLTVTQRISQASGEITGVDAESIGRAVDIAVDQAAGEVREDGSVTGLRIRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4A9</accession>
    <name>A0A010Z4A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3215154_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="44" mass="4821" checksum="295E7BC6B15118A1" modified="2014-06-11" version="1">MVSLIHALVHELWPLPVEAPGVFLPLLVVLATAIPCFDSDRIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4K5</accession>
    <name>A0A010Z4K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118462_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="133" mass="14514" checksum="67439B61F6AE3863" modified="2014-06-11" version="1">MIELPVDRTLLIRTDFTDDAGWLAVRGLLEGHARDSGTELRFVEERAFDGRTPEQLGVDLGADPERSFAFVADASTLATAEHPVLVVDLADLPGRAFRVVAPGVAAVQEALELSNISFDVYLRRCDEDGVFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4S3</accession>
    <name>A0A010Z4S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1913557_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14679" checksum="093C774A61570BF2" modified="2014-06-11" version="1">MPVDRWAALSEALALGLTRLAIDDFLVLDAAAGYVQCYQHDDRLLTEALDTGDPRLRELGWGDPDEVDQNLSVVVAWPFSHGAACELAERWVRTLRDVYDADPNTLRYLAANASSNDDWDAGYLGIAQRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5K5</accession>
    <name>A0A010Z5K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="28601" checksum="E5A30566B0557290" modified="2014-06-11" version="1">MSGRIDAHVHLWHRATDPQPWIDPGTMGAIDRDFGSDDLARMLADTGVDTAVVVQTVNDLGETQRLLSRSEPVVGWIDLTADAAAQLEKLGADGRLVGIRHLVHVDPDPQWLGRPDVGASFDTLAEHGLGFDLVVRWWQLDLAASVAAARPGTRFVLDHLGGIAECDDDEGWERGLRTLAALPNVTAKISGLAALVSDADRLRRVADVALDAFGPHRLMYGSDWPLALLGAGPVSWRAAVDALVADLSTGERRAIDGGTAAAWYGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6F8</accession>
    <name>A0A010Z6F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725734.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4059"/>
    <dbReference type="HOGENOM" id="CLU_209062_0_0_11"/>
    <dbReference type="OrthoDB" id="2026896at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="48" mass="5408" checksum="2E5E28DDF7D2387B" modified="2014-06-11" version="1">MKTKLSCPCGEWIEGVDEDDLVARTQAHLAAAHPDLDYSRDEILFLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6G6</accession>
    <name>A0A010Z6G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037147_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="26961" checksum="620A69C23C29D512" modified="2014-06-11" version="1">MAWGGSRCRMARSTAWHGAGRGTARHGARRPARGRHGTVRCDTARGGAARRSAGRRGPARHGAVRHDTTRHGAARGGAARHGTARAARCGTTRHDTTRGGAVRGGAVRRGAAQCGAAWGGPARHARYGAARHGTRGMGRPGTAFAAWGGMGRGGPARGGTTRHGAGRGGAARGGAAQRAAAWGGGAGRGGGGRRGSGHGSALTTNAGRVRGLAPTSFGGLERVLGPTRAAVAPGSRRRPGKRSVQAVVGPRNSATRALETVALEWEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK72</accession>
    <name>A0A010ZK72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847472.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.72"/>
    <dbReference type="HOGENOM" id="CLU_044146_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="29177" checksum="3A0AB7EEDE96B4DF" modified="2014-06-11" version="1">MFVPKLVATDLDGTLLRSDLTVSERTLATFSRLERSGITLVFVTGRPWRWMDPVLAQTGRRGRVVCANGAVVLDGASGEVLRNWTIPTGTLRAVTTSVRETFPDAIYAVERGPRMLHEAGYPVRHDLGRTDEDQVSYAELIAEPVEKLLIRAPSVEAAELWTRCTRVFDDTVTATHSGFRGLIEVSAPGVTKATGLAWVAQHYGVDPGGVLAFGDMPNDIPMLSWAGRGVVVAGAHPEAAAVAHTVTTGNDADGVATYIDALLDEAEATTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKA9</accession>
    <name>A0A010ZKA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.107"/>
    <dbReference type="HOGENOM" id="CLU_008537_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009188">
        <property type="entry name" value="NiFe-hyd_mat_HypX/HoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006787">
        <property type="entry name" value="Hydrgn_mat_HoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_C" evidence="1">
        <location>
            <begin position="200"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="586" mass="63801" checksum="67CBA6F2CA71A845" modified="2014-06-11" version="1">MRSLLLTFRRRSNSRPPRREEQSPQSLRILLLVSSFNGLTQRVWCELRDRGHTVAVEFARDAESIADAARRADPHLILCPFLKERVPTEVWQKWTTVIIHPGPVGDRGPSSLDWAVTEGKRAWGVTALQAVEEMDAGPVWASRTFPLPKDPPTKSALYNGPVADAAMSCVDELLTKLATTDFRPTPPEQLAKTVVRPTMRQTDRAFSWSDPAEAIVRKIRAADGAPGVRTEIAGVAVWAFDAYVGPSRSDPPGSVVASRDGAVLVAAGTGSVWLGHLKALGDAERSVKLPATVVLDGHLPSTSKSPNDPGPGRVHYVRRDDVGYVVLDCYNGALSTEACNQALHALRHAARQDTTAIVLRGGSGPFCNGIHLNRIEAAANPAAEAWANITAINDVCRELVNCRGQVTIAAFSGNAGAGGVMLPLGADLVVAREGVVLNPFYEMGLTGSELHTYTLPRRVGPDAAKRLLSEKLPVGTAQAKKLGLVDEIGPRDLAAFGGWLHDVARRYRDRTLRERTLRHKVDVLERDLSAKPLDAYEARELGEMAQDMFDDRQGFDAARRAFVQKRAPERTPTRLALHRAPGFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKC1</accession>
    <name>A0A010ZKC1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847546.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.118"/>
    <dbReference type="HOGENOM" id="CLU_043648_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="30730" checksum="2A45B834D5526189" modified="2014-06-11" version="1">MSDFEAATGAFRRELTAHCYRMLGSWDEAEDAVQETYLRAWRGWAAFEHRASARTWLHRIATNVALSALDGRRRRALPSGLDADEPEAGWIQPSSDDMRLALIAGLQTLTPSQRAVLLLRDVLAFPTPDVAEMLGLTPGAVKSALQRARARLARTAPLRDDVVEPRSPQARRQLDAYLNAFRSADVAGLTEVLREDLVLEVMPGRAWFNGLRECLPVLVEGVGRPGEWRMEPTIANGQPAARVHRFGEPAGVVVLDCRRDGIARISVFGDPTLVARFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMC5</accession>
    <name>A0A010ZMC5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848584.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.834"/>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="357" mass="37049" checksum="41B6AD455CCDF118" modified="2014-06-11" version="1">MTTTETLPEDVVEEAHPSLMQRLGALQSVWILGVLVLIVLFFSIVAGDRFLSTSNFSLISQNVAVWAVIAVGMTFVIVTSGIDLSVGSVLVFSSVISAKTMEAVGGEGWGVAGLGVLAALVSGLAWGMLNGFLVAKAKIPPLIVTLGSLSVALGLAQVITDGIDIRAVPEVMTDYNTYIKILGIPALPFTAFVVVVIGGVILHRTRFGRYTYAVGSNELAARRVGVRVDRHLIKVYGLAGLLSGFAAVLALAQFGTTTIAGQSLTNLNVIAAVVIGGTSIFGGEGSIFGTVVGLFIPAVLQAGFVIVGVQPFWQGVAVGTVLVAAVYFDQSRRKAAARGAGAQRFSLRSKLIGKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMN9</accession>
    <name>A0A010ZMN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569757.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.980"/>
    <dbReference type="HOGENOM" id="CLU_377550_0_0_11"/>
    <dbReference type="OrthoDB" id="1356233at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="638"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="734" mass="75880" checksum="5B9B0375BC142F9E" modified="2014-06-11" version="1">MTTGNTDEKPDDRALAPVAGSGLLARYGDLVLLYAAPEGDDDRTAEVLDAIASAAGGDGRRLGRRLASLLLTAGNQDLDFPPLAAFGPVGDGVAVIVHGAAQVSIVTDDGEIVLDGRDALTWVDRMIPAPARVIRGALDTLGGGSHDPWARLDAGVVRAGGFVFGVPSAIAAAPSPAGRPAAPLAPVRSLSAVPSRPEADALPTPDDLGSVRATSPADAHHDAAPADAYRGTPAETPTPADPYRDPSSAPADRFGDPSSTPADRFDDPSSAPADVPRAVPAPSTEATRESFRAEPAPDEDSQNESRAVPPPTEVVRRVPTSPSITSVPSEVEDDDVPQSTEAYNPFADDSAARPLPVELPSAEPADEAGPRGAASVQRGGHDAPAAFSAPAAPSYDEPPRMPAYDDASRVPTFDDPPRVPTFDDPASFDSPMPPAPPGPPPTPFGDSAPPPPPPFGEPSPLPPPPPGGFGGYDSPVSAPPGGFDGGSSPDSPVHTPTGPSPVLPDQPLADQAVQPSSAPPAASGGGYDPAAPFEAVLLIGDQAEVEDRSQTSGPLPPADVQPPPGPVPADGAEEADARPIVLGIYCKNDHFNDPRVPYCAVCGISMAQLTHVSRTGPRPPLGLLVLDDGATFRLDTDYVVGREPERDEAVLQGRARALRIDDPKGVVSRIHARIELDGWDVNVVDLASANGTHIAPPNSESWTRLEAHRKVTLTPGTRVVFGRRGFRYESHRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNK9</accession>
    <name>A0A010ZNK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid-binding protein, PBP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849061.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1294"/>
    <dbReference type="HOGENOM" id="CLU_083918_2_1_11"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="17493" checksum="19292BEF9426B003" modified="2014-06-11" version="1">MNDPFARLPEAATFTVTSSSVTDGAPFAAEQRAGKDLSPQLSWSGAPEHTKSYAVTVYDPDAPTGSGFWHWAVADLPATVTSLPEGAGDDTGSGLPNGAYQLPNDARLARYIGAAPPSGHGEHRYVIVVHALDVENIGVPADATPALLGFTISGHVLGRAVLTATAETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP56</accession>
    <name>A0A010ZP56_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849370.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1517"/>
    <dbReference type="HOGENOM" id="CLU_028163_0_1_11"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="408" mass="44341" checksum="A7157A4B7E974190" modified="2014-06-11" version="1">MTDPGAERLVAEPAKDPGTGRTPYQRDRARVLHSAAFRRLAAKTQVITASGDDFLRTRLTHSLEVAQIAREMGVALGADPDVVDTAGLAHDLGHPPFGHNGEDALDVVAQPAGGFEGNAQTLRVVSRLEAKVPGAGLNLTRATLDAITKYPWGRKPGTRKFNVYPDDQPVFEWYREQAPPDRRCLEAQIMDWADDVAYSVHDLEDGVHAGHVRIELLADPDERDALCADVARVYSPESPGDLRAVLTELLAEPVVEGLARYDGSHLAQSRLKQVTSALVGRLSAVAVRATREKTGPGPLRGYAADLEIPRRARAECALLKGLALRYVMNRPGANARYVRQREILTRLVEALLHRAPDALDPIFAPLWKSAADDAARLRVVIDQVASLTDPAAVAWHDRLAGPLEGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPB2</accession>
    <name>A0A010ZPB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ring-cleavage extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847491.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.81"/>
    <dbReference type="HOGENOM" id="CLU_046006_19_1_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="18655" checksum="6872404D67A30224" modified="2014-06-11" version="1">MPIQRLNHAVLYVRDVARSVAFYREALGFDVIEGGDAFPGAAFLRAGGSTNDHDLGLFQIGAEAGPSQAGRTTVGLYHLAWEVDTLAELQRVEAKLVELGALVGASDHSTTKALYAKDPDGIEFEVSWLVPAALLTDEIRARRNEIRRLDLAAEAERFGADTHGGVGVSVPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPC0</accession>
    <name>A0A010ZPC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.90"/>
    <dbReference type="HOGENOM" id="CLU_091682_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="228" mass="24817" checksum="705CEE232E490989" modified="2014-06-11" version="1">MLITRVSSRRISWGTTRPMRFQKFGHACVLVEDADARVLIDPGAFAQGWEELRDLTAVLVTHQHFDHLDVERLPGLLAANPDAVVYTDQASAGILAEDGIRAEGVAAGASLQLNGLSVEAIGVEHAVIHPDIPIIPNVGFLLGGRFFHPGDALTVPDRPIEILGAPTAAPWLKLWEAIDYVRAVAPRIAIPIHEKAAAFPQMYYQNMSKLSAESTAVEIIDDGEVREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPF9</accession>
    <name>A0A010ZPF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569917.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1620"/>
    <dbReference type="HOGENOM" id="CLU_110454_1_0_11"/>
    <dbReference type="OrthoDB" id="1760741at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11887" checksum="7AF682494CAD20D5" modified="2014-06-11" version="1">MSDLSDLSAATAEFAAVRAWQPWHTPKNLAMALSGEVGELTTLFQWLTPEESTAVMADEKLADEVRDELADVLLYLVQLARVLDVDLAEVARAKLARNEHRFPPPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPQ0</accession>
    <name>A0A010ZPQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849644.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1708"/>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="133"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="31367" checksum="A84EC640C0C6EB52" modified="2014-06-11" version="1">MTIRIGIASTAHPHSASYAAALSRRPDVELRVAELDELLAWAPHGVVICAENHRHRELTERAAAAGVHVLCEKPLATNVADAVAMIDACERAGVHLATAYPVRFHPALAALRAGRPGRLYSAVGVNTGIAPGGWFADTASGGGAILDHTVHLADLLTALVDAPPVEVYAQANRIVAGAGGDAETGGLLVVTHADGFVASIDCSWSEPSGFPRWGGLSLTLHGSGGSVHFDPFADELTGYDATRTASAPYLDLDALLLADFVDAIRERRPPDRTALRSLAVAEAASTSAATGRPEPVHPLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQL3</accession>
    <name>A0A010ZQL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein, possibly involved in motility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2029"/>
    <dbReference type="HOGENOM" id="CLU_173020_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="10123" checksum="522270BEA4FC3245" modified="2014-06-11" version="1">MLTRLNGQEFALNPDLIERADVTPDTVITLVDNTKYVVLESLADVTRLIRQYRAAVIAEAQRAVLEPQNPTLTATDDAASQIVVPLHRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRD9</accession>
    <name>A0A010ZRD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2842417_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="65" mass="7482" checksum="35949986CEEB44E9" modified="2014-06-11" version="1">MGINAYIGCPDLQCDYRVRFHAPDVTSPPDSLIEAWTQLLWVEHPLHPRSLPRHRSQTVPARPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRU9</accession>
    <name>A0A010ZRU9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">CryarDRAFT_2480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850667.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2443"/>
    <dbReference type="HOGENOM" id="CLU_123265_0_0_11"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="14502" checksum="DA32FEB0C17E1C05" modified="2014-06-11" version="1">MARVKRAVNAQKKRRTTLEAAKGYRGQRSRLYRKAKEQLLHSATYSYRDRKARKGDFRQLWITRINAAARAEGLTYNRFIQGLRLAEIEIDRKVLADLAVNDAAAFAAIVAVAKAALPEDTSAPREDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSA5</accession>
    <name>A0A010ZSA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860876.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1146"/>
    <dbReference type="HOGENOM" id="CLU_117532_0_0_11"/>
    <dbReference type="OrthoDB" id="1147201at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="181" mass="19327" checksum="44DB454BC83BE4E2" modified="2014-06-11" version="1">MVVVIIGCEIGFWVLLGAGLAARYLLRQKRLGAALLVATAFVDLVALVAAVIDLRGGATADWSHGLAALYIGFSVAFGPMMVRWADERFAHRFAGGPAPTGPPKYGTPRAVHEWKLWLRAVIACGISGALLFGAIRLVDDAERTEALGGTLSVLPRIVVIWGIVALTYTVFPKTRPAHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSB7</accession>
    <name>A0A010ZSB7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase-like enzyme</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850939.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2652"/>
    <dbReference type="HOGENOM" id="CLU_038732_1_0_11"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="34820" checksum="82BF25E531C2A435" modified="2014-06-11" version="1">MSVLTTRFTELFGVEHPVVQGGMQWVGRAELAAAVSEAGGLGLITALTQPTPADLAKEIEKARTLTDKPFGVNLTILPTITPPPYDEYRRVIVDAGITIVETAGSNPEPHMDLFKANGVKILHKCTSVRHALKAQRIGVDAVSIDGFECAGHPGEDDVPGLVLIPAAADKLTIPFIASGGFGDARGLVAALALGADGINMGSRFMCTVESPIDQAVKQAIVDADERDTELIFRPLRNTARVAKNAVSVEVVRILNEGGQFADVQHLVAGARGRTVYENGDVEAGIWSVGMVQGIIHDIPAAGDLVRRIVTEAAEIIQGRLASLVTAVGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSD6</accession>
    <name>A0A010ZSD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2259067_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="103" mass="11399" checksum="FB0B8E5696D62B2E" modified="2014-06-11" version="1">MTLPTDRLFDGWCPDPGHPRLEESINPVSERDAGWCTECQAWWAPDPSWALGIESVDLTVPGRGGDFTLWRVDAGELNASRGGVPAVLARYRDRTLTGWGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSH2</accession>
    <name>A0A010ZSH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein, gamma-carboxymuconolactone decarboxylase subunit like protein</fullName>
            <ecNumber evidence="2">4.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.44" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2724"/>
    <dbReference type="HOGENOM" id="CLU_070025_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047575">
        <property type="term" value="F:4-carboxymuconolactone decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="136" mass="15003" checksum="120EA0692D9834B1" modified="2014-06-11" version="1">MRNDESRLARGETVRREVLGDAHVDRSMARATEFSAVVQEYVTASCWGDVWSRPGLDRRTRSLLNLAMLTALNRPHEFAVHVRGALRNGCTVAEIQEVLLQTAPYCGAPAALESFRVAERTIEEVHAEAAVDGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSY4</accession>
    <name>A0A010ZSY4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570192.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2871"/>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="350"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="505" mass="53140" checksum="E84E94C3AF02E68C" modified="2014-06-11" version="1">MATTVRKGPPAWLAFLAAGLIGVVTFRLVPVGGATSLVYLTLVLAGAVAVGAGMWIHRPRAIGAWGLLAAGQLALFAGSVPVYLGPLLGFDKPDFPSLLTIIYVAQYPLTGVGLLLLIRRRAPSWDVASLIDAAILTVSASLLSWIYLISPLTADPALTRLDEVAIAAFPLGDLLLLAVGARLMLGAGLRPPALWLLAGYLVLLTLGDTGQSVEALNGMLLIGGTWPETLWVLAAVALGVAGLHPSVRAVEEVSPTADPDAGTRRLVLLAVASLLAPVTLLVQYLRGASLHVPLVCATCALLFLLVLGRMARLVATQREVAITDSLTGLHTRRYFEHSLTVEGERALRGAGLAVLLLDIDHFKAINDTYGHHGGDRVLCEVATRLRVVMRGGDLVARYGGEEFAVLVPNTVPPIAREIAERVRLAISETPMPVNPTTSTTITVSIGVATMPEDATNVDDLVLLADQLLYASKETGRDRVTSTVNRAAPTGSAPAVDETTTTAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSZ3</accession>
    <name>A0A010ZSZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849164.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1372"/>
    <dbReference type="HOGENOM" id="CLU_069356_15_5_11"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="20593" checksum="6AAD5B203F6434E3" modified="2014-06-11" version="1">MAPGKPLTFVEQARRAQIVGVTIDVVAEHGFAKASLQRIADAAGLTKAAVLYHFPSKDAIVRAAYGSVLHSLTDDVGRAVDAASGAAALDAYVHSLVAHLRAHPAHVRMIVEAVVERTGADDVPSGPSRRDAVASLVEQAVAAGDYREGIDPIVVAVLVNGAVDAIVGQLLDDPAFDTAGAATELTELLRRGYGRNTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT24</accession>
    <name>A0A010ZT24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851291.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038005_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29909" checksum="A8F5DB3E3C25ADE7" modified="2014-06-11" version="1">MTLRIATLNVCGLPSWLSRLPPIEDRAAGIGRSLEASEVDVFTVQELWGRRSARALQRHLPSFRHVAWHAAASGGPAGGVATFSRRPLGPVRYRSFAGTAPRTSTPSFRAWRALNARRQGMLAVTLDDVLIVTTHLTANKDGDWSEGNRYYQFHRDQLAVLHAFVRERGPARQTVLTGDFNIASRSPLHRFVTEDGAWHDPFEHTDLTTFRAEYLPRGSTVHRIDYILLDGPAEAHDARALFADEVLSDHVGLTLALRGGTRVVTPPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTC7</accession>
    <name>A0A010ZTC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1525"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="26914" checksum="6F480359756F23CF" modified="2014-06-11" version="1">MRAGRRSAVLDGMDDQAVGLRGVTKTYGRKSARVTALDGVDLDCPAGTFTAVMGPSGSGKSTLLQCAAGLDRPDRGSVLVAGVDLTRLSETRLARLRRDRIGFVFQSFNLLPSLTAEQNVGLPLRLAGRRPGRDTIRGALAQVGLAGRERHRPGELSGGQQQRVAIARALVSAPPVLFADEPTGALDSAAGRGVLEMLRAMTGRTIVMVTHDPVAAAYADRVVFLVDGRPVEELDRPTHASVVERMARLAEPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTG7</accession>
    <name>A0A010ZTG7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2648400_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="76" mass="9410" checksum="9B1D5EB8C391BFB5" modified="2014-06-11" version="1">MFLPLPRRSSRRPIRANLLAHRENARPQTSRSLDDLSGCYDYVPCNDWDYNECRPRRRRHRKKRYNDCWDYKNYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTI1</accession>
    <name>A0A010ZTI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1584"/>
    <dbReference type="HOGENOM" id="CLU_063440_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11710" checksum="B0AA526824A1A065" modified="2014-06-11" version="1">MREPTYFILAALQDEPRYGYAIIKQVEVLSQGRVTLATGTLYSALDRLTAEGFVGVVREEIVNGRARRYYEVTPDGLAALRAEAAHLANAAKVVTDRMTLRPATGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTK9</accession>
    <name>A0A010ZTK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569915.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1607"/>
    <dbReference type="HOGENOM" id="CLU_005679_10_1_11"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="413"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="642" mass="68801" checksum="0E0CC7A5DFD73651" modified="2014-06-11" version="1">MTSSAALVPPVRTTGSDGTLGYRPALDGLRAIAVGAVLVYHLGAPWLPGGFLGVDLFFVLSGFLITTLLVEEWRARGRVDLGRFWLRRVRRLLPAALLVVTAVMAVGWRTVDPSQLATLRADGLWTIFYGANWHLIGSGQSYFDAFAAPSPLRHAWSLAIEEQFYLVWPLLVLVVLRALGVKGLGLVIAVLATVSAVLMAVRYQADDPSRAYYGTDTRVHELLIGAGAALVRLRIGPLRRAHTVAAGIAVLGAFVLMPDEWVGFYRGGAVVFALVAAVLVLGTIDHPARLLTRAPVVWAGRLSYGIYLWHWPVYCWVDDAGTTTGAVEVGVKIGGTLALATASYYLVEQPIRRGRVFTGPRIAFAAPTAIAAVVGVTLAGTAAATAPVPIEPKDVRTLSTPRTFVAAGTTTQLRLATVGDSVVKSLAPGLAEAAKERNWSYTDASVSSCSVEGLLMVEADGSPWSTGAICPEVVPTVQQRLLDEVRPDVILVHSRWETYRVRGADGDPLDADTDAHKAFVAERLRATMSRLTSGGARVVWIDTTPMSESLCRRLGHSDSACARTATDAVVDSYTALRENVAEEFGGRVSALSLNDLLCEGERCPDTVGGKTPRPDGLHFTVESAEWIVPELLRRVASVTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTN2</accession>
    <name>A0A010ZTN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1627"/>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_11"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="21810" checksum="33E1292B3E339226" modified="2014-06-11" version="1">MALTREQLAARAALELRDGQYVNLGIGLPTLIPNYVPDGVHVTLQSENGILGVGPYPYEGDEDPDLINAGKETVTLLPGASFFDSAMSFAMIRGGHIDVAILGAMQVSATGDIANWVIPGKMIKGMGGAMDLVHGAKRVIVVMEHVARDGSAKILEECSLPLTGKACVQQIITDLAVIEVTPNGLELVETAPGVTVDEVVAATAAPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUI3</accession>
    <name>A0A010ZUI3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852053.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3470"/>
    <dbReference type="HOGENOM" id="CLU_039483_1_1_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="24942" checksum="4F94138393914150" modified="2014-06-11" version="1">MFPIASSEFVQIFRNRAVLISTLMPLAVSAFFIYRRDIFAQLGSDGYVAAILVITIGAFSLYATAVTTLAARRQDLFLKRLRSTTAGDAAILSGLTLPVSVLATVQAVVVLAVFAAVTDGPADGVLLIVAILVTFLMMIALALATAGLTGSPEQAQVTTLPVSLLTIGVASWVGIAGTDELTVLKRLLPGGSAAELIVNSWNGGVPLAESLPLLGPALAWVVVAVVLALKLFRWEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUP5</accession>
    <name>A0A010ZUP5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861573.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1987"/>
    <dbReference type="HOGENOM" id="CLU_077385_0_0_11"/>
    <dbReference type="OrthoDB" id="1265024at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="19918" checksum="A013882564164ED5" modified="2014-06-11" version="1">MAPNGAEPDPFASAVATLRAVRTRPEILLEEVPAPQRLAPRSFALSGTVVRGDEEVATGRLIVLHDPSGQEAWDGHWRVVSYVTAELESEMGTDPMLAAVGWSWLLDALDLSGARYGAIGGTVTQVSSTRFGELAGPPTSSDVEVRASWTPMLDTSPDLAPHLDAWCGLLASTAGLPPPGITVLAAHNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV41</accession>
    <name>A0A010ZV41_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="4">
        <location>
            <begin position="150"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="662"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="859" mass="91973" checksum="05E0E7DFAED51AB8" modified="2014-06-11" version="1">MENADADEPRRPIAARIAARGRRAWRLPQRLLAEAGVGLLAGIAVYAGILANLQDGLRGAQLGQALVASTLSGLLALLTARAGGFAVRRGRHAPPAGPTEDTAPTPARPLAMSNLHPRNQNFTGREAILADLATRFGDPAAASGPVGQVLYGLGGVGKTQLALEYAHRRRADYDVVWWIAAEEGTTVAAELAALARRLGVAEVADQADMTDALWNVLRDGIRWLLIFDNAENGGDLEPYWPAIGGHVLVTSRNPHWAGLAGTVEVDVLDRAESVAFLRSRVATDVEATRDLADALGDLPLALEQAAAYVSQTKITVSAYVELVRDRLPDVLHRGEPFAHKEPVATTWSIALDQLNLRAPAAAELLTLCAMLAPDDIPRGLPVQGAARLPDRLREAVADPLTYADAVGALVRFSLVSAHDDSLSVHRLVQAVVRTRAGPADEPFWATRALHLIADAFPFATDEPASWPGCERMLPHALTVVARTERLGVEPDRTAELLTSAGSYLAERFRLKDAASAFQRALAIDESAHGPQHPLVAVDLGYLAAVAQSGGELHEARQYMERAVAITSAAYGPDHEAVAEARNSLGRTLQNLGEWPAARTELEEALEILMQVFSPDHPRIAAVRNTLGGVLQDLDDLAGARDQLEQALAVDEAAFGPDDPAVASICGNLGRVLQQMGETDAARAQLERALEIDERRYGSSHPRFAVDLNNLGRLLHDLGDLTGARRLLERALEIDEETLGSGRYQVAMRANNLGGVLQDLGDVQGARAHYERALTIIERSFGPQHRSLAVVRSNLGTLLRQAGDESGAREQFALAVDITTATFGPDNPETQRARSLLERSAPVAGPPTATYPVPPVGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVF4</accession>
    <name>A0A010ZVF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850400.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2260"/>
    <dbReference type="HOGENOM" id="CLU_062618_6_0_11"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="25673" checksum="DC1A609D5DE47BE6" modified="2014-06-11" version="1">MTPAPGALDRGLGILRLVAQHRRMPVAGIADALGLSRATAYRLVERLRDEGWLISEGHGGPVRLGPTAAQLAAAALESVNLRDVAIPVLRELVEATGETANLAVPNGAEMVFVAREQPVRTVSVVAYTGSTRPFHTTSLGRAYLMALPAPRRAELVTDADLERKLDTMRARGWSEDRREFDPSSCCCGAPIRDHTGEPVAALSVAGVAERMDPVLDEVGPQVRDAAARISASLGYLPPLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVW1</accession>
    <name>A0A010ZVW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2860181_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459248" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="64" mass="7160" checksum="640606CA2D186E3B" modified="2014-06-11" version="1">MTRAFEKMADRFVSAFVPKTTAGACECNDCYYTGCTNGYCKRCCTNCHCTSTTCSSCTYRPEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW88</accession>
    <name>A0A010ZW88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="175" mass="19336" checksum="8941BEC9682BFDAF" modified="2014-06-11" version="1">MRGKPQAFAGLEEFVADRGDALLATAILLAGGRDAGQDLLQAAIERAMRRWHTIDGDPEGYVRRILYHLAVDSWRRRSRRPEVLTAVDTEAVPDATATLDLRDALIRALAQLPPKQRAVLVLRFFEHLTEAEAAERLGCSIGTVKSATSRGLARLRELTNDWAAERPRTTNGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWZ0</accession>
    <name>A0A010ZWZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862282.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2813"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_11"/>
    <dbReference type="OrthoDB" id="1439833at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="286" mass="30816" checksum="63B927A19A48FFF9" modified="2014-06-11" version="1">MYIHGFDYQRVPTADGVALNVATAGTGTPIVLLHGFPQTHLMWRHVAADLAADHTVIVPDLRGYGDSDKPAEGYAKRTMAADVVAVAKALGHDRFALAGHDRGALVAIRAGLDHPDTITHLASLDVLPTLESWDVLRGVRASVGYHLFLMAQPPGLPEKMIGAVPDEFFGSFLDAWAQNPDAIPADVRAEYLRASRNAVTSIVADYRASATIDLEHDAADKEAGHRLSMPVTVLQQDWGAALGFDAAAIWRAWAADLDHRLVTAGHFMAEEAPAEVIKAIRDLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX48</accession>
    <name>A0A010ZX48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="213"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="334"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="601" mass="63908" checksum="BE0C51F0D7DC6F15" modified="2014-06-11" version="1">MTTANQRGRRRIRPSVIATGPAMARTAGACYVTGGVIGLVSHWAARHDWGGADRSGTAWVLGLSVAALLAGVGLALAGRRLPQWTFYAISHVSAAVLTLEVWLLRGRPETIAIASLFVIVVMYTSFFFEWAAAALTTAHALTAIVVAKLLWDAVPWVGVVALVGLSVLVAGITVALIRAAADADVDGLTGLPNRRGFDRLLQTTLTDAERGSGQLSVAILDLDGFTATNEQQGRAEGDKRLQTFARDWVAQAGEDVVMARHGADEFAIVWPGATSGKLSAQLDAFRAVHPEFSAGVAVWQTGDTASLLASRAEIALYEAKSSGGGRTFSSNDAGGESWMLLSSALTNNEFSVAYQPIVSGATGLVTGAEALLRWNRPGKGPVSPAEFIPIAESSGFISKLDHWVLETACREAAAWPRAVPAKVTVNVSGRELHQPDYYQQVVDVLIRTGLPAQRLVLEVTESTMEADSPVALDALRRLRADGVRIAIDDFGTGYSSLSRLHHLPADILKIDRSFVSTIQPQDNGAPLIAAITGLAHALGLTTVAEGVEQQYQADVLRHHGCDENQGWLHGRPDAPELIHAALAQQALSQPSVSFEQRAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXD2</accession>
    <name>A0A010ZXD2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3355692_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="36" mass="3823" checksum="C1A626AAA8C8FCBB" modified="2014-06-11" version="1">MDLSGYRHVAPTERSLTGPSDSSQAQAEFDRLTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZM6</accession>
    <name>A0A010ZZM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852615.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3845"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="385" mass="42481" checksum="0C16960A5D5FA14D" modified="2014-06-11" version="1">MSEITPFRIDIPQAAVDDLTDRLRRTRWVEELPEPEVVAGGAGVPAPPGWEYGVPGAYVRTLVERWSTSYDWRAQEAALNEFPQFTTEIDGQRIHFVHVRSDRPDATPLILTHGWPNTFVEYLDLVGPLTDPAAYGHPDAPAFHVVVPSLPGFAFSGPTREHGWNAGRVAAAWSELMRRLGYDRYGAHGNDCGSIVSPLLGELDRAHVLGVHVTQIFSFPRGDDGEFDGLSGEDYGALQFGQAFAEHAVHDRAQQAQPQTLAHALADSPAGQLAWSGQLFGTDLSPDTILTNAALYWFTNTAASAGRFYFENHRAAQADAETKPTSVPIGVAVFARDFRAVRRFADRDHANIVAWNTYDRGGHWAAHDAPDLLVDDIRRFFSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZR3</accession>
    <name>A0A010ZZR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192634_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="11784" checksum="D07CE4EFB688EFB3" modified="2014-06-11" version="1">MSGPLGYAHRTMVNVFLHRCRRAADLPVEHVPDAGRDDDAPAAVDSAAATRQVLAGLPPTQRAAIALRYFADLPDEEIGRLLGCTPRTVRSQVSRGLAALRRRWAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAF8</accession>
    <name>A0A011AAF8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.14"/>
    <dbReference type="HOGENOM" id="CLU_216330_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="42" mass="4690" checksum="5373F698653D1D65" modified="2014-06-11" version="1">MWKKALVLATVAGIAVLAAKKFKEASDERELWHEATTAPDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAS1</accession>
    <name>A0A011AAS1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.136"/>
    <dbReference type="HOGENOM" id="CLU_032896_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="446" mass="46330" checksum="DB669652376BA02C" modified="2014-06-11" version="1">MRLSEFGPTPGDALLRAEAAAVQAENAAVRDEWTRLNEAEEAAEDGRGVTRRTVLLGAGLGATTLLTSQFLNVRASFGATGTGTLIHVFLFGGLDGLSLVAPGNDPVLTKVRPSLALPTGSSIALARGFALNRAFEPLKTYLDAGQLGFVHGVSDPRLSRSHFQCQDACELGGLPSETAGRGWLDVLTEKLGTGTAFRSIGVGSTLRRSLVGTQGALALRNVGALAINGDEKFRQPTADAIKTMFTGLDHPAADSVKAAVGALATASKLSSVPYAPANGAKYPGGLGDGFKTLAQLIKGGANVRTAAVSMGGFDTHSNAGTNGGHLFNQFTQIAQTLRAFFDDLGEARKDVTVVLSSEFGRRVAQNGSGTDHGHGNVVTILSGKKLSGSVIGEWGGLGSLDNGDVPEFNNMFDVFGTIAQKQFGLSAAEVASVFRKRSFKPLPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABB4</accession>
    <name>A0A011ABB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.298"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35891" checksum="8FBE37D5E92908B1" modified="2014-06-11" version="1">MGRSALGGGRSTLAAMANPPDDVVVLHDGPWSHRFVSANGSRFHVVEVGTGPLVLFLHGFPEYWWTWRHQLEPLAEAGYHVVAVDLRGYGASDKPPRGYDGFTLASDVSGLIRALGERDAMLVGHDWGGALAWATAAFHPRQVRRMVVIGSPHPLRLRAAIAGDPRGQLAASRTLFTFQTPRYEHRVTANDAAYVESLFEKWAGPRWRETDDYAQYTRACRVAIQIPQAAFCAMEYYRWSLRSLTRPTGWRYAKLMQADITAPTLQLHGADDTYLLPRTAEGSSRYVTGGYEWQVLDGVGHFPQAEQPDLVTEELLRWAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACL3</accession>
    <name>A0A011ACL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PemK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.789"/>
    <dbReference type="HOGENOM" id="CLU_097054_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458497" evidence="2">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="18041" checksum="B4581712BF72C1A1" modified="2014-06-11" version="1">MAQTLRKVLSKLRPKRAARRGPSPAEMAARVNGGTPAPSGRHLTYAPNLDGDADPGEIVWTWVPYEDDPIQGKDRPVLVVGRQGKKLLGLMLSSKSDRDGQRDWFALGAGEWDRENRPSWIRLDRVIEVDEDGIRREGAILPRDRFDAVAKQLRTEYNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACY1</accession>
    <name>A0A011ACY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848687.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.947"/>
    <dbReference type="HOGENOM" id="CLU_069356_25_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21054" checksum="28DED282887D9E5C" modified="2014-06-11" version="1">MSERPGGRTARVRAAVLRAAEDALIEKGFAGLDLADVARRAVVGKTTVYRRWKTVPALVADLLVDMAAQSRPRADTGSLEADLRENARLVQRTLTDPRQGPLFRAFLAAALTDPETAAALHGFYATRIAEWAPCVSAAVRRGELPADTSASEVVRAVSAPLYYRLLVGDPLEPHHADTAVTAAIAAARAGTYVSAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADC7</accession>
    <name>A0A011ADC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848846.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1102"/>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="57"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="454" mass="48651" checksum="E9FF3DE542A4491A" modified="2014-06-11" version="1">MDADTLIRNTTIITMDAERRIVTDGAIAWSGDRIVALGKSADVDVTAKTTIDGRRFLVTPGFVNGHVHLTEALLKGFMPEALPFDESLFTWVMPLYEAHTPAEQQAAARLAALSMMRTGTTTFLDASTTVALDEVFEAVEPTGLRGRFGRWQQDRAFGPDGQLEATDAALRALETDLARYPGGDGQRLAAWPMLVGHNTNTDELWRGAKALADAQGAGISAHLSPAPNDAEWFVANTGRRPVEHLAHLGVLGPNLNLVHMVHVDAAELELLAESGTNVTHCPAAALKGGYGSAAVGRFPEMAAAGVNLALGTDGSDIADMMKPMNLMAGLFKDARRDTSMFPATAALEMATVNGARAMGLADSIGSLAVGKKADVVLHDLDRPEWRPVNNYVRQLVWSADGRGVHSVWIDGRRVVDDYVCTTLDEEKVLADAQAAADAIMGRSGLPYVYDWPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE17</accession>
    <name>A0A011AE17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569836.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1307"/>
    <dbReference type="HOGENOM" id="CLU_065134_0_0_11"/>
    <dbReference type="OrthoDB" id="1577717at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459461" evidence="3">
        <location>
            <begin position="31"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="40183" checksum="06240078BA76DCE9" modified="2014-06-11" version="1">MQRTVVTLLAVVVALLLGTAAPARAHGADAKPEATDYRTAITAVTPSTDDVTVHVIENGARLELRSDTTQDVEVRGYSGEPYLKISADGVWTNTRSPATWINATADGKSPVPASARVDTAAAPQWQKVSSERVVRWHDHRSHWMSTSPPPAVTAAPASSHRLASWTVALVVAGTPTTVSGTLDYEPPPTPTLWWAAVVLAAAALFAVTYFWGRRPAARLLVAGALGVAALAELADAVGRTIVAGSTGFGVVTGVLTGQGVGLLVSLAALAAAVVTIRGTDAGPFALAFAGVCLALLGGLPDYETFAHAVPAVPWPGPVARLLTTALLGFSLGAALSGWWWLLQARRDARSAPAANGTTADDTTADDTTADDTTADGATAALEKTEAPRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE76</accession>
    <name>A0A011AE76_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815633_0_0_11"/>
    <dbReference type="OrthoDB" id="1576962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="340" mass="37647" checksum="EE068A01AC9B4085" modified="2014-06-11" version="1">MLAAGVSALVVLVWFVAWIGRDEPDEVVRDYLEALSAGRTAEALDISRAEDVPTGPFLRREALSRGWTIDAVETPKVVEGGIPDFENEDVYSVAYRLGGGHRGEFRLAEDGWSWRIDDPLVSVPFWPRLFSFLQIGPVRVPLRPDDPTTVRSDATRFWMFPGVYTPYANVPSTALAPKNPRLIVTDQGSYDPEFTVTAAGNRTAQAAVDAVLDDCVALRTAQCTMAPWYDSRYDTEKGLVDPEDVTTQRWRIVRRPAISVRDSRDPNGTDGPLETYVVTPGVLRLDATGLDRDYDPVGFAQTCEINKFRLPTRLSDAGVLTFPRDGDPVHVELKCTSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AET4</accession>
    <name>A0A011AET4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849481.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1601"/>
    <dbReference type="HOGENOM" id="CLU_038034_7_3_11"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458383" evidence="1">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="34825" checksum="7224106761C27ADC" modified="2014-06-11" version="1">MRLRHGLVASLLLLTGCGGAAGSTAPDSGYPISVTNCDRSVSVGKRIERAVSISQPASELLLSLGLEDRMAGTASWSDPVLPALATANAKVPRIAKDFPSFERLLEDEPDFVYTTFAYTYTAEGVADRARFDQVKIPTYLSSSECTGQDATQTRALTIDDLYREITDLATLFDVPDRGTALVDSLKKRMATAVDARDVSLAWWYSSTKAPYIAGCCGTPGLVTAAVGAKNAFADGKQLWPETGWESILDRDPDVLVLADLTRGDDGDSAAAKIAFLESDPVARRLTAVKNKRYVVLSGSDMDPGVRTVQAVEKVSAGLTKLGYGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEY9</accession>
    <name>A0A011AEY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1654"/>
    <dbReference type="HOGENOM" id="CLU_1904558_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="137" mass="14715" checksum="96FA032396BF74E8" modified="2014-06-11" version="1">MTITPVTICLPIADRRTSFRFYRDGLAFEPVGEVADDGVPEPLQFALNEGVRLMLIPTGGFGWVIGDRNVASRGISECVLDLPAETDGAVDAFLERAHRAGAEIVSGAGRQPWGYGGTFADPDGHLWMVTSQEKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFP9</accession>
    <name>A0A011AFP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">CryarDRAFT_1941</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1905"/>
    <dbReference type="HOGENOM" id="CLU_057426_0_1_11"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EXG80846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="244" mass="23841" checksum="F2E7C5CCF1587F77" modified="2014-06-11" version="1">MDRETAGGAMLLAPLVGAGVGLAAGVVLLIAALVGIPPLAAGVLGVGTLALVTRGLHLDGLADTADGLGSYGEPQRALAVMKAPDIGPFGVITLILVAVAQVACLAAVTGTRAVLPLLLLPAVASATGRTAVTWACRVGTPPARPNGLGALVAGTVSPVALALTTGAMVVVAAVATGVGGPTFWRGPLAVAAGLVVAWALVRHCVRRFGGVTGDVLGAACEVATTAALVVLVIQPWSVSLPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFW2</accession>
    <name>A0A011AFW2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850044.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1976"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="34221" checksum="C31EE093C6AE0818" modified="2014-06-11" version="1">MSAPTVTRPEAPAHAVLEIEGVSRWFGNVVAVNDISMSIGTGVTGLLGPNGAGKTTLLHLMAGLLQPSRGSIRLGDAPVWRNPGIYASLGLVVDREDTYGFLSARELVEATAKLHRLPHARAAADRAIAMVGLGSAADRRIATYSKGMRQRARVAAALVHDPAVLLLDEPFNGMDPRQRLELMELLQRMGEAGRTVLFSSHILEEVEQVSQQIQVMVAGRLAASGDHRAIRRLMTQRPHEFRLASSDDRALGVALLGLECVSGVELEPPGLLVRARDYGAFTRALPPTARSAGVRLYQVLPADESLESVFSYLIEGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGJ5</accession>
    <name>A0A011AGJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850327.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2206"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_11"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24366" checksum="02219D592259CF23" modified="2014-06-11" version="1">MRVVFVHGACVRDGAWWWHPTAAALRERGIQSVAPALPSCGEGDRPAGPQGPGLAEDVASVRAALTATDEPTVLVGHSYGGIVAAEAAAGVASVRHLVFVSSYLAEPGESLSTFGSETPPPFLDFDPDGGTFGAVPELFGETFVPDCPPEIVRDGATRLVRQTITVLQQPVRAAGWHDVPTTYVVCADDRGTPASAQREFARRADKVVELPTGHHPFLSRPELVADLVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH69</accession>
    <name>A0A011AH69_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">CryarDRAFT_2462</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850647.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2425"/>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_11"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="209"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="202"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="421" mass="44534" checksum="1F6721E744143A25" modified="2014-06-11" version="1">MTFGSIEQAIADIAAGKAVVVVDDEDRENEGDLVFAASAATADLLAFTIRYSSGVVCAPVTGADADRLGLPPMHHTNQDSKGTAYTVSVDARDKTTTGISAAERALTIRLLGDPAATADDFTRPGHVFPLRAVDGGVLARPGHTEAAIDLARMAGRYPAGAVSEVVNDDGTMARLPELIEFSRAHDLTLITIADLIAYRRRTERQISREVDARLPTRHGAFRAVGYRSTVDDTDHVAFVLGEVSGGDDVLVRVHSECLTGDVFGSLRCDCGPQLETALAAVAAEGRGVVVYLRGHEGRGIGLLSKLHAYQLQDSGADTVDANLELGLPVDARDYAIGAQILLDLGVRSVRLLTNNPAKQASLERYGLPVAGRVGLPTHAHPENVRYLTTKRDRMGHEIVGLPDEIAVASAVLDQASLGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH89</accession>
    <name>A0A011AH89_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">CryarDRAFT_2487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850681.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2450"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_11"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="389" mass="39951" checksum="7019238CDB2C0320" modified="2014-06-11" version="1">MSDMSARWRAALMDNYGTPATALVKGDGAVVWDDNGNQYVDMYAGIAVNVLGHAHPAIVEAVSAQVATLGHVSNLFANVPAITLAERLLGISGRDGRVYFCNSGAEANEAAFKLSRRTGKTHIVATQGGFHGRTMGALALTGQPAKQDPFRPLPGDVTHVPFGDAEALEQAVTDETAMVILEPTLGEGGVVPAPPGYLVRAREITQKRNALLTIDEVQTGIGRTGFWFAHQADGIQPDVVTLAKGLGGGLPLGATLAFGEAAALFGPGSHGSTFGGNPVCCAAALAVLDTIVQDDLLARAKHLGERLRAGITHPAVVTTRGSGALLGIVLAEDVAKAAEAALAEAGFLVNAIAPGVLRLAPPLILTDDQVDAFLAALPAALDTATGKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHF9</accession>
    <name>A0A011AHF9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2408306_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="92" mass="9690" checksum="22594CEFE0013E71" modified="2014-06-11" version="1">MVSPWSRAVVTLWALAGLLVLFQPNTGVLAFVAVALLAALALRRVGIQLPTLTPPRLAAGARRAASRGAPRHRDPDARGHSRPRAPTTLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIX1</accession>
    <name>A0A011AIX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Na+-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570247.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3051"/>
    <dbReference type="HOGENOM" id="CLU_034788_0_1_11"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="298" mass="30710" checksum="EB2BBE7F8B5CC0BE" modified="2014-06-11" version="1">MNDAALITVGLPIALAVIMFGLGLSLTPGDFRRVAAAPKAVAVALVLQVLVLPLVAFGLVILFDLEPLLAVGVMLLAASPGGTTANLFSHLFRGDVALNVSLTAINSVLAAVTLPLITNLAIDYFEADGSLGLQWAKVLQVIAIVLVPVAIGMAVRHRSGAFAARADKPVRVFSIVVLVLVAAGALFGERENLVGYARDVGLVTGLFCAASLTLGHAGARLLRLSEPQAIACAMEVGIHNTTIALTIALSVLDNTEVAIPAAVYSVTMYVLAPAFGFAITRRRRTGVTAGDTAPGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIZ4</accession>
    <name>A0A011AIZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677420_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="406" mass="43535" checksum="7591123996144722" modified="2014-06-11" version="1">MVLLVSQHRIREALGLLREISPDNPVAAGHVTEILLRRGEFSEVERLLDEADRRGDPHTTAWWNQLHHARGDAAALRANAERGDRAAAVRLLALLDSRAQHAEADRWLSTQQSHGDLRAWVGHTLANRLDEREDVEGLRRLADAGNSMAAECYLAAARRHHGYDVLEQWAAAGHSGARTYLTELLAERGDADVLRGLASTGDTYAEALLIELLCSTRDVAALASEASNDNAAALTGLIRLLVEDGDQAGLQELAEAGHLHAARALAKMQMNVDDLAGALETLTAYGDQADAETSSLVAHILYRAGDRHGLEARAETGDDDAAGALVALLIRLKDRDALWDYAAAGRPAACRALADALDQWGYDDDAALVRRLGLDAAGRAMPGPDAIPGPTSRTLRRDVLSAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ95</accession>
    <name>A0A011AJ95_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851670.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3191"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459603" evidence="1">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="253" mass="26001" checksum="414361FAA1A355CD" modified="2014-06-11" version="1">MSLLDRFRLDGRVAIVTGASSGLGVAFAAGFAEAGADVVLAARRADRLAGTADLVCAAGPRALAVTTDVTDPDQCAALVDAAMAEFGRVDVLINNAGVGTAVPALRETPDQFSAVVDLNLNASYWVAQACGRVMRPGSAIVNVSSVLAITTAGLPQAAYTASKAGVIGLTRDLAQQWGSRRGIRVNAIAPGFFKSEMTDQYPPGYLESLRGRMLLGRMGDPQELAATAVWLASDAAGYVTGQTVVVDGGVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKN7</accession>
    <name>A0A011AKN7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852411.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3698"/>
    <dbReference type="HOGENOM" id="CLU_031026_2_2_11"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="397" mass="41186" checksum="D7803A71B7CD7671" modified="2014-06-11" version="1">MSSSFVYASVRTPFGRFNGALADTRPDDLAATALKGLLDRSPGLDPGLVGDVFWGNANGAGEDNRNVGRMAVLLAGLPVSVTATTVNRLCGSSLDAAMMATRMIEVGDAEIAIAGGVESMTRAPWVLPKPSRRYPAGDVTAVSTTLGWRLVNERMPAEWTASLGECNEQLQEKFSISRERQDEFGARSHRLAAQAWDRGFYDDLVVPVRGTDLVRDESIRADTSVDKLAGLKPAFRPDGTITAGNCSPLNDGASAVLLGSAGAAASIGRDPVARIAGRGGAALEPQHFGYAPVDAADRALERAGITWADVGAVELNEAFAVQSIACVDAWLELGLPDAELVNATGGAIAIGHPLGASGGRVLGTLAARLVESGERWGVAAICIGVGQGLAVVLENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALY2</accession>
    <name>A0A011ALY2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_4172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051572126.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4147"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_76_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="226"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="460"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="575" mass="62316" checksum="EA5924F7D2300DEB" modified="2014-06-11" version="1">MNDDVVLRVHLRGEADVFALRHSGRAVAAAVGLDASDQTRVATALSEIGRVLLAAPTAVTALFRVALRALRVELSGVTDRTLTGVRERPGPDGLAGAARLVDDLRVVQDADHVTITLVKTVRTPIDPALVRAELAALRPTTPADELWRQNQELLAALDEAERSRDSQIRMNEELEETNRGVLALYNELTEELEHTNQGVVALYAELEDRSQRLREANDAKTRFLRHVNHELRAPVNSILGLVRVMTTVADPPFSAEQEHQIELVGHSAADLLRMVNDLLDLAKAEATRIQPAWEPVDLRVLLGQLRAALGPANARADVTLAVADPDPPPDLVSDGLLLTQVLRNLMTNALKYTVRGEVRLDVRAEAGTITFVVTDTGIGIEADQHERIFEEFYQVPGALQAQVGGTGLGLALVRRLVAALGGELDLRSAPGEGTTVTVVLPREPQRPADEIAAPASGPIRIVVVDDDPTFRRVLRSALDAVDDDDREIAEVADAREALPLIRRVRPHVVFLDLRMPGVSGEEILAGLRAEEALAATPVVVVTSETSWTPVDDPHLTVLSKTSLDVAAVADAVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFR4</accession>
    <name>A0A010YFR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069365_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="281" mass="30837" checksum="9517776A017CE117" modified="2014-06-11" version="1">MPGPWSSYVAIGDSFTEGMDDPYTDGTYRGWADLVAGCLAAVTETDDFRYANLAVRGRLLPAVVDAQVPLAAAMKPCLVTFSAGGNDTIRRRFDPQRMTEVFEGAVDRLTSSGADVVLFTPPDVTVNYPAATRYLGPRLHFSTELVRRVAKEYDTYLADLNADDGFRDRRVWSIDRLHLNPAGHRRVAHHVLSSLGVECDAEWMASLPMATPDRWLTARRADLQWARAHLAPWIGRRLTGRSSGDTITAKRPDLANYSSSSPMPRSHSPGSCSGRVGGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHN9</accession>
    <name>A0A010YHN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6x reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848540.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.803"/>
    <dbReference type="HOGENOM" id="CLU_068627_1_0_11"/>
    <dbReference type="OrthoDB" id="1726104at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="241" mass="25205" checksum="BE7F5762D3390A93" modified="2014-06-11" version="1">MSRVLILGGTGDARRLASLLIGGHDVVSSLAGRVRSPLLPPGEVRIGGFGGVDGLAAYLPGFDAVIDATHPFAARMTAHAVEACARVGVPLAVLRRPGWDEEPGDRWVRVPSVADAAEALSPGQRVFLTTGVRGLDAFAGGDQWFLIRCVDPPSVPLPPRSSVLLARGPFAYADELALLREHSIDVVVTKDSGGRATYPKLEAARTLGLPVVMITRPVLPPSASTVGTPEAAARWLESQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHT0</accession>
    <name>A0A010YHT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848611.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.860"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26637" checksum="BE78EE3298682753" modified="2014-06-11" version="1">MSKIAVITGANRGLGRNTALRLAEDGVDVILTYRSNADEAQEVVDELTKLGRTAVAFRLDVGDLAAHEAFVDEVRGALADRWGRDTFDYLVNNAGTGVYASIADTTVEQFDSLLGVHLRGPFFLTQRLIPLLADGGRVLNLSTGLARFTSPGYAAYAAMKGAVEVFTRYLAQELGPRGITVNTLAPGVIATDFAGGAVRDNPGLQEMLSQRIALGRVGRPEDIGTVAASLLSDRSGWITGQRIEASGGQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHW4</accession>
    <name>A0A010YHW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051820_2_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="293" mass="31738" checksum="313B2582F3F1A719" modified="2014-06-11" version="1">MKMRYTYNRIFDPPVVAGVHANEGSEPADDKMYVFDDEDVILAVNLAIASGRPLLVYGPAGSGKSALAPNIARELQAPLFSQVMTSRTDFSELLWKFDSIKRLADAQTQRLLKEEEYVVHGVLWEALASQANPQNPVPAVVLLDEIDKASPDLPNGLLGPLGSLSFRGPQGNDVSSASGKAPLIIITSNNDRELSRPFLRRCVVVTLKPPTKNHLMGVAAARFGKATAAAFEDVASAIGNRYLEPGAPLSDLPSTGEFLDAIRASIELDIRPETPAWRFLSKAILAKYDSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIG3</accession>
    <name>A0A010YIG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865247_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001457876" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34313" checksum="EF56477BCE50EC23" modified="2014-06-11" version="1">MVTGLVTMGAMSLSAAPANAAEKSENLVKGTAEFVDGRYVVEWSVTNQDKETDEKITAVVWPEDSKLELDDEIEAGETIEGKQFLPKGSKGIKDAQGRDVAKIHVHGEWRKDGKKVEHDEFVDVPLPPVKGESPKPTHKPSEDEVSAAIVLSCEAFSIELTNPTDRPVRFKVFIKLDDNRPLTEEFKVDAGDTLTLPEDLDKEDAGSVAKVSEDGELDFSKITVAVVNRDKKLAQKSLDVTKCEDEDNNAEETTSPEASPSASASEVASGGDDNEAAPSPAAEEDSLPVTGASLGGLIAAAVLVLGLGVGMVVFTRRKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJC8</accession>
    <name>A0A010YJC8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2166763_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458807" evidence="1">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="110" mass="12362" checksum="AD4036E77559DB97" modified="2014-06-11" version="1">MSSKFMRGLVLAGVATASLASVAAPASAATQSTAPAAKKAAIVVICDGYAPVYGCQYPDYLDYPWAGDYYRGGDYYYYGRPGFYWGRGDNWGWGGRHHRHWRGHHHRRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJJ7</accession>
    <name>A0A010YJJ7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">CryarDRAFT_1483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849273.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1456"/>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_11"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="215"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="365" mass="37810" checksum="6B8B6A3CA2EAFA8B" modified="2014-06-11" version="1">MRSAVAGAQRIVVKIGSSSLTVRGGRLATERIDALVDVLAERRKAGAQIVLVSSGAIAAGIAPLGLSRRPRDLATQQASASVGQMLLVARYAASFERYGLTVGQVLLTADDMIRRAHYRNASRNFERLLELGVVPIVNENDAVATDEIRFGDNDRLAALVAHLLRADALVLLSDVDGLYSGDPRQPGARLVSTVLSAADLNDVVAGSVGASGVGTGGMASKVAAAQVATSAGVHVVLTSAPRAADALAGADVGTYFAPTGRRLPTRLLWLRHATTPRGHLVLDDGAVEAVVSRRASLLSAGITAVSGDFVAGDPVDLVSSAGMSVARGLVAYDASELPPLLGKSTHAVGPKYRREVVHRDDLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJK5</accession>
    <name>A0A010YJK5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="8" type="ORF">CryarDRAFT_1494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849289.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1467"/>
    <dbReference type="HOGENOM" id="CLU_160655_0_1_11"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="86" mass="9345" checksum="D3F17BC89A61361B" modified="2014-06-11" version="1">MANIKSQIKRIKTNEKARLRNKAVKSSLKTAIRKFRTAADAGDREVALTELRNASRALDKATSKGVIHANQAANKKSAMAKRAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK94</accession>
    <name>A0A010YK94_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849646.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_11"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="130"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="33554" checksum="7CA190AD6322707B" modified="2014-06-11" version="1">MRVAVIGAGAIARPHVAAWTSLGAHVRIHSSHGASALARAYGGTAVDTLEECLDGVEVVDVCTPTPTHAPIVLAAAARRLHVVCEKPLALDHRTAAGLIDACRDAGVRLFPGHVVRYFPAYAAAHRLVTEQGTVGRVAVTRLSRTTMTPSAPWLTDPARSGGVLVDQMIHDFDFARWIAGPVVDVFARLTGGPPWTGHALLRHESGALTQVTGQWGRPGTAFRTSFAIRGSSGGLDHDSRDTAPLRWEPEPPADALLPAFDATGSPFRAELADFVTALRTGAPARVTPEDSLAALDVALAAVRSVRENRPVDPKEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKI7</accession>
    <name>A0A010YKI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849788.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1797"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="315" mass="33350" checksum="ACDD2E6A2B5A5AA2" modified="2014-06-11" version="1">MRYLPLGNSGLLVSAVGLGCNNFGGRLDVDRTRAVVDAALDTGITLLDTADTYGGGGASESVLGEVLAGRRDEVVLATKFGHRRTDLGYGAAAGAKGGRAYVRRAVEESLRRLRTDHIDLLQLHTPDPVTPISETLSALDELVRDGKVRYLGHSNFAGWQLAEAAHVARELGTVPFVSAQNHWSLLERDVERELVPAARHYGVGVLPYFPLANGLLTGKVRRGQPVPENSRLAGRDGYVTEEKLDRVEALVKWGDEAGRSLLEIAIGGLAAQPGCGSVIAGATSPEQVRANAAAGEWVPSAAELTALDELVPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLL6</accession>
    <name>A0A010YLL6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075802_1_0_11"/>
    <dbReference type="OrthoDB" id="1740922at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="242" mass="25466" checksum="1D455AB68A362391" modified="2014-06-11" version="1">MTSATNHVDQLLGAYALDAMDDVERAAVERHLRTCPTCAAEAAELTATTARLGAAAVTTPPPHLRARVLGAAQRTAQHHRAARRPAPRRRRGAAAAAAAVVLVSSVGGTWWAQENRITHERARVIAAEQESADIRAVLTASDAEFRVAANLPSGHLAAVYSSSHRAAVVTFADLGDVPAGKTYQFWRLIGQNPRSLGALPEGTRRGSLIVHDLNGTDQIAVSIENAGGAPVPTKVHAVLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLW5</accession>
    <name>A0A010YLW5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116199_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="16036" checksum="32940152BCDFD95E" modified="2014-06-11" version="1">MTQTQVLPLQERNPDQPGKRVVADVLVRDQQGRVLLVDDDLPGSDVAAHESPWTAAQRALHEGLGLDRPPTRLLVVDYVDDHLTLIFDAGTLSDAQTEAIRARKSAFCDPGEAGELLPEQGRPRLSAACEALRFGVSRYLQDGEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMJ4</accession>
    <name>A0A010YMJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850782.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2520"/>
    <dbReference type="HOGENOM" id="CLU_035309_0_0_11"/>
    <dbReference type="OrthoDB" id="1809199at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="400" mass="40512" checksum="ED5CAACB8B80579D" modified="2014-06-11" version="1">MSAEAPAVSRSVVVAWRNAVFAVFAINGFALATWMSRVPAVRDALGASTAEMGWVVFSIAAGSIVGLSSASHVLAWVGSRRTIAAAVVVGCVGLSVVGLGSTLSTHGVFVVVGLALLGCGMGMCDVAMNVEGAAAERELGRTVMPLFHAAFSGGTIAGAALGALAEWADVSTAVHFGAIAVASVAALGVSVRFLHLDAQGFAGAGDDAAHPGWRERLSMWADRRTLLIGLIVLGMAFAEGSANDWLALAMVDGHDVSNSTGAVVYGVFVTAMTVGRVAGVFFLDRYGRVPVLWTTTVLAAGGLLIVIFAPWAGLATAGVVLWGLGASLGFPVGMSAAADDSRTATARVSVVATIGYFAFLVGPPSIGFLGDGVGLLHALLLVFALIIVAGFATPAARERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YNN2</accession>
    <name>A0A010YNN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851189.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2837"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="445"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="546" mass="58768" checksum="CB1408CE5B63AC3E" modified="2014-06-11" version="1">MPKLPSYSSGTSAVALLGDTIGANLDRTAARVGDHEALVECATGRRFSYPQLLAEVDACALGLAALGVRKGDRVGIWAPNCAEWVFVQYGTAKLGAILVNINPAYRTHELAFVLKQAGISVLVAAPEFKTSDYRAMVGEVGDDCPDLTTTIFLGDPAWDALLAAGRAGDPSTLPDDLDPDDPINIQYTSGTTGFPKGATLTHHNLLNNGFFVGEGCGYTEADRVCIPVPYYHCFGMGMGNLGATSHGATMVIPAPGFDPAATLKAVQDERCTSLYGVPTMFIAELGLPDFATYDLSSLRTGIMAGSPCPVEVMKRVVSEMGMTEVTICYGMTETSPVSTQTGADDSLDRRTSTVGRVHPHLEIKVVDPATGRTVARGETGEFCTRGYSVMRGYWNEPTKTAEVLDPAGWMHTGDLATMDDEGYVNIVGRIKDMVIRGGENVYPREVEEFLYTHPDVVDAQVIGVPDARFGEELMAWVRLRPDAEPLTAESLRAYCTGKLAHFKIPRYVKIVESFPMTVTGKIRKVEMRETAVTELGLEAEAAARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPG8</accession>
    <name>A0A010YPG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851659.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3185"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="513" mass="54265" checksum="65AB6C228E2B24F2" modified="2014-06-11" version="1">MISPTWVSPVRWDEAEALVEPTPAELGRIAPDRLHVVDGDVRLDGAALLAAVAGAQHRLRAVGVGRGDVVGVQLPNWWEAVVVAHAVWGMGAVLCPVPVNYRGAELDRILAATPVAAFVVPARYRGVNHPALVGDVLERRGISAPVVEVRGASPFPGTGAAPELDAALDDVCVLMFTSGTTGTPKGVLHSHRTLLADAWSIARLFALDGDLVYMPSPVGHVTGLVYGVMMPLLVGGAVLLQAEWEAAVGADLIEEHGATFCVGATPFLRGLTDEYARRGTASALTGFACGGADIPAALVRRATDVLGAAVTRAYGLTEMPTVTCGGPDDPERVRFETDGRLTGSSQARLNDDGELEVRGPELCLGYLDPEHTRASFTDDGWFRTGDLARLGADGSVTITGRAKDIIVRGGENIGVKEIEDYLLDHPAIRDVAVVGVPDDVLGERACAFLVTAAPLTLAEIAEFLLARRIAKHKLPEYVLVVDGLPRTPSGKIQKFRLREQAVAELAAGRGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPU0</accession>
    <name>A0A010YPU0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851848.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3315"/>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="32309" checksum="A6FFE276B3782E9A" modified="2014-06-11" version="1">MTVLEPADALDPAPLRARSVWHRLARDPAFVTGAAIAVVMTLLALAAPLLAAWEGQDPTTFHDDLLDSARGGVPIGPLGGIDGTHWLGVEPGTGRDLFVRVLYGARVSLGVGVAATLVEVLIGVTVGLAAGLGGRIADAVLGRFADLAIAFPSLVLAVALLAIVPDSWPRPLLLTLVIGFLGWGGTARITRAETVSLRTRDYVAAARLAGAGRARIARREILPGLAAPVLAYAALLVPQNMIAEAALSFLGVGVRPPTASWGQMLSSATTWFRSDPMYVIVPGGLLFLTLLAFTLAATSLRRALDPRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQX2</accession>
    <name>A0A010YQX2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2823885_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458134" evidence="2">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="66" mass="6880" checksum="2DB8BD08EB5E7204" modified="2014-06-11" version="1">MPRRLLLVFGLAAVAIVAAFLVTLGVVESGDPVPADRTSAEPSPTGPAPTEAANDDYRPNPFGKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRB3</accession>
    <name>A0A010YRB3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852661.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3900"/>
    <dbReference type="HOGENOM" id="CLU_087927_0_0_11"/>
    <dbReference type="OrthoDB" id="1070946at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="29847" checksum="3111B9237C9A6AE6" modified="2014-06-11" version="1">MTADAGPDARDAIYTDGITALPGAFDVAWADRMRVDIETAFAEASARPGGAVGRGPNRYYVEIHPEQLRGFVDLVSHPWVRAVCAAVLGEDYRIVELGFDIPFAGAVGQPWHRDFPMPDVTRAQRRLNSLAFNLTGVDTTDEMGPFEIAPGTQFDDEPDFEHGMFPPRSRYGRYEERAVRKYPRRGDISARSALTIHRGTRNRSAVARPVLVLGVDAADATNDDKHDLAVTAAYWATLPADVRAHLHCPIVDRLTPITQKHTIEGLVMGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRY9</accession>
    <name>A0A010YRY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570714.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635722_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="41955" checksum="FD2538A732273DA4" modified="2014-06-11" version="1">MSLPPPPSYAAGPLPYGSPPPAPPRAGRAASVRVARVAGVIGLVGAVVTAVGFATFCAADAISQNDDGRAYNDYGTSTFVAMAATTLILLLVTVAAPIGSLAGSGGRSGGRAVAWAFVPLVLPAYFIGVAGNMSAVVDDENSTAVRIGTAAGTGAAAVGVVAVLVAAVAWALPGARDFLIERRRTVLPGRGRTTLLVVAGLGGFAVLLYGVTIGLDLFGRAQADAAPATDAYSYGDDAAAHFVAGSAVAALLVAAELTLVAGALVVRSGRVAWVRGVTFTLAWMTLGGSVPAVGYFAVVWSIAGESDNGDPGVGAGRAAFFVGLAAALLHLVALVLLAMPSVSAWVASRAPRTPRPGPGGPLPDPGGPWSGPPGPWSGPGGPWSGPGGPAAANPATGPLGAGRPAGGPGAGSWPTGPVVSGGHHGAAGNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YS22</accession>
    <name>A0A010YS22_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4195"/>
    <dbReference type="HOGENOM" id="CLU_059319_3_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="34863" checksum="5A1D539D91F9CFA2" modified="2014-06-11" version="1">MDDRTAELSAAQDVAPVPQAYRPPAQRGPSEAPTIPDSASAGWNTRAAADAWNPTRAAEAPPAAGWSSGPAAPAAPADAPGPDSQAPVRYDADAPIPEAPPSYPGQHRAPRPKYFALRIAAVLVLVLGAAVGVAFTVIGDSDPDTVQVADDLPPDNQALAPTAGPDAAPSPTQPDPAEQQQAIDNAQNRAEEKAADAQADAAALADDAEEAREKRAKETGTTGAPVPTAPVDCETLSGNKNTGCALLSEFGFPTSEMTCLEQLWTKESGWNEKAENTGSGAYGIPQALPGDKMASVADDWRTNPATQIRWGLGYIKGKYDTPCGAWNYFQNNGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVM0</accession>
    <name>A0A010YVM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847686.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.203"/>
    <dbReference type="HOGENOM" id="CLU_929740_0_0_11"/>
    <dbReference type="OrthoDB" id="2007494at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="299" mass="30482" checksum="3B8ACBCD516EE164" modified="2014-06-11" version="1">MNELLPAYAAGSLSATDHARVDAHLRGCARCRADLAGWQAIATSAAEPPGGLGDAPEAGQLVREVLTRSAFEEPVGLPPTRRLRHLAGLLVAEARLIRLAVPVASALVMALGVVVVLFQAGPDRIADLMLALIAPIVAAAGVSGTYRSDHDPATELVAATPTSERLLLLVRLTLVFGYDLALALAASAVLSVSGAAGTADLNALVGAWLGPMALLSALSLLGAVRFGPDVALGLAVGLWAVRVLAASLLTADGWPARAIVHAWSTNAPVLTLSAALAAAAVLLAGRGEPHRGRRATHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVZ9</accession>
    <name>A0A010YVZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing a CheY-like receiver domain and an HD-GYP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847868.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.321"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_11"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="145" mass="16362" checksum="801E79956A009BAA" modified="2014-06-11" version="1">MTEPLPIEVLLVEDDPGDVLMTREAFEDHKLRNSLHVVNNGADALLFLRKQGEFAGVPTPDLVLLDLNLPRMDGREVLAEIKADETLRRIPVVVLTTSEAEEDVLRSYNLHANAYVTKPVDFEQFVNVVRQVDEFFLTVVRLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWK9</accession>
    <name>A0A010YWK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2',5' RNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848271.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.566"/>
    <dbReference type="HOGENOM" id="CLU_2342060_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="97" mass="10623" checksum="311EC5FDB07E62A9" modified="2014-06-11" version="1">MDHLRSTVETLHVTRADAGVVRSDMWHLTLAFLGEVTDPEMVRDRVAECAADKIHLMRSTANAYDSLADWPVPPQGPCLNLEPAQGDAADRAGGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWZ2</accession>
    <name>A0A010YWZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569694.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="297"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="438"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="697" mass="73770" checksum="788F83A11E4D9E51" modified="2014-06-11" version="1">MTAVDLTLDPEPGSGGDRRRAFAASWARALRPADTTTTTADELVGAVERLVEAVSGGSFDPGPAASAGTALVDRGFGDPAALGASLRLLTTEFPALVPGAAARVGELTAAFATGFTVARERELVRKAALGAQAEAQHAMRTGESRFRAVFGGVPVGLALGTPDGRLTEVNDGLAGLLGLPAGALVGRRLSEFLVAAHRSVLEDAYTRLVADEVPCHLECRLARPGGAETWLSIRLSLVVDETGPRTHTLLVEDVTEQRTLRLTADHLATHDRLTGLANREVFVERLTGVLRERTGAERIGLCLLDLDGFKVVNDSLGHPVGDQLLAAVGERLDTLSGDALVARLGGDEFGILLTGTSGVADVERLAAEIVRSLAVPFPPADGRLTLPASIGVVEHAASDASAADLIRAAELTMYRAKAEHRGRWAVYDPHRNDQRVARYTLATEMAAALERDEFVVEFQPLVGLADGAVGGAEALVRWRHRELGLLSPKRFVGLAEETGAIVPIGRRVLELACRQASRWPSVGQEPPYVSVNLAAAQLADPNLVDDVVRVLEETGLEAGRLQLELAAGTVTTVNTTPLRRLAALGVRLAVGDVSAGWANLPLLRDFSIDVLKLSGGVVQRLTASDRTALDDQILESLLVLAHALGLQVVAEGIESGEQRDRLRSLGCDTGQGWYYAPALGPEEFIRYLPGSPAFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YX92</accession>
    <name>A0A010YX92_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="4">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mtnC</name>
        <name evidence="5" type="ORF">CryarDRAFT_0823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848550.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.812"/>
    <dbReference type="HOGENOM" id="CLU_023273_0_0_11"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043715">
        <property type="term" value="F:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043716">
        <property type="term" value="F:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="237" mass="25540" checksum="8B5D761133E5AD5C" modified="2014-06-11" version="1">MTHTARVVVLDIEGTTSAAGFVQGDLYDYARPRLRSWIADHADDPAIVSAVADTRAEGGLADDADLDAVVAVLHGWMDTDVKATPLKTIQGQLWAAGFAAGELRSHFFADVVPRLREWHERGLRLVSFSSGSIASQVPWYRHADAGDLTPLIEDYFDTVKAGSKREVSSYEKIASALGVAGDDTLFLTDLPAELDAAAAAGWQVIGVRREGEPNYAADFGDHPVVSSFDEVDVRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXI1</accession>
    <name>A0A010YXI1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848669.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.928"/>
    <dbReference type="HOGENOM" id="CLU_065200_4_1_11"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="162" mass="17226" checksum="F99F7EEA7D8B3A3A" modified="2014-06-11" version="1">MRSRVAAVGSGVFFAIAPGTVAGVVPWSLTGWRTGAAPLPLRVAGAVLVIAGAAVLLHAFARFVHEGLGTPAPVAPTAHLVVGGLYRYVRNPMYLAVVTTILGQALLLGRPVLLAYAGLIAATTATFVHLYEEPTLRAQFGTEYDAYREAVPGWWPRRVRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY94</accession>
    <name>A0A010YY94_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1230"/>
    <dbReference type="HOGENOM" id="CLU_092690_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="19742" checksum="3168F3348ECB5B4B" modified="2014-06-11" version="1">MSSLVYRGEVSVVISVSKDSEHHFSKRPVDEIVLLAGLGVEGDAHAGVTVQHRSRVAVDPTQPNLRQVHLIQSELIDELADFDLAPGGLGENVLTRGIDLLALPTGAVLRLGADATIEITGLRNPCRQIDGYRSGLLKQVLTKDERGSIVRRAGVMGVVTAGGVVRPGDAVAVTMPPPPHQALERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYU1</accession>
    <name>A0A010YYU1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849239.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1435"/>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_11"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="152" mass="16733" checksum="84C27D22666DEF78" modified="2014-06-11" version="1">MDTGELAPDFELPDQDGVPRKLTTLLAEGGPVVLFFYPAAMSPGCTAESCHFRDLAKEFAAVGAQRIGISNDRVEVQSEFAGRHNLDYPLLSDLDGTVAAEYGVKRRLGPLAVKRHTFVIDVDRRVLAVVRSELRMSVHADKALEVLRNRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYX5</accession>
    <name>A0A010YYX5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569882.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1469"/>
    <dbReference type="HOGENOM" id="CLU_012341_2_1_11"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="264"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="714"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="810" mass="82113" checksum="A73EF026795C58A0" modified="2014-06-11" version="1">MFTLTTLKARWTGLLGTIVAVALGAALISGAAELLAGVGARDGLSTALTLYPEAPIVVQGTRQDDGSIVAAPPPPPPGVEKRLASVPGVTAAIADRAFSVRVAAVGVQEGRGWASSRLAGVRLVSGSAPGDGEVVLGREAGVAPGGTVTARLADGDHRLRVSGLVDGPAVYVSDAAAARWGTVRAVGVLTDSHDVDAVAVAVRRVAGAGTTVRTGADRWFAEPDPGRQQLDDATALLGISAGLAGFVAIFVVGSTFAFAVSQRRREFALLRLVGAQPRQVRRSVHVEALVVGGLAAAVGSLLGVPLSTVYAVLLENADLVPEAFAPRARFWPLTIGFGVGLVVSMIGSWAAARRAGRVPAIDALRDATVERRTMTVGRWVFGLLFLAGAIASIVAAVGVDGEGAIALTVFVGELFVVAFALLAPVVIPPVIRLVTAPLARAGGAGPMLVRQGALTAVRRVASTAAPVLVTVGVAGSMIGAIATLADTTDADLRARLTADVIVVPGDGPGLNADVPAAVRAAVPDATVSATLATTVWEVVPKNADGVYEGHDLSGSALGVDPATLRRTLDVAVVEGSLADLRPGTITASEISGLDVGDSVRVTFADGVTSKLRVAAVVASIQSTSVLLPIETVREHDPSALADAVYVRGGSPDAVRSAVTPLGGQAIDRTAYADLRSAEADEGNTLALTALLGVALLYTGLAIVNTLLMATFDRRRELALLRLSGATPRQGLRVVVAEAALVVLVGSGLAIAATVLSLLGLTSALSRVVGEASPSIPWIPLGVSIAVCLVLAVVAAAAPAWSLLRRPPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZR8</accession>
    <name>A0A010YZR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849720.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1754"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="300" mass="30894" checksum="4F207F50471528BE" modified="2014-06-11" version="1">MELRQLAYFLAVVDAGSFTKAADRVRVAQPGVSAQIRRLEREFGQPLLDRSGRSVRLTEAGTAVVPYARAALAAVDAARQAVDELTGLLRGRVALGMITSCGPLGLPGILAEFHRRYPAVEVTLTEDGSDELTLAVRAGTLDAAIIGLPSTAPPGLATQLVTDEPLVGVVAADHPLAGRDLLALSELRASPLISLPEGTGIRSRLEDACAAAGFAPSIAFEASDPFLLAELAARGLGLAVLPASVVTPPPHGVRPIAIVEPALRGQLALAWRASGPTNPAAAAFLTHAREALAGRPGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z028</accession>
    <name>A0A010Z028_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3167048_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="47" mass="5214" checksum="B3208DF92B44039A" modified="2014-06-11" version="1">MADPEGQWKTVRAAIRGWGPTLRLITIMTAPTVATVAVLVLYQALWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z057</accession>
    <name>A0A010Z057_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2842418_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="65" mass="7178" checksum="571201E238594F81" modified="2014-06-11" version="1">MTTVQPLRQLVTSAIALLPEGGQRTARRNAWAAMSEDNRRARDRREAAAAFAVPPAIARRANQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z084</accession>
    <name>A0A010Z084_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093882_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="26915" checksum="F48E680765FABB88" modified="2014-06-11" version="1">MPPPLPPRVAAAVAATVAELVAAGTSGVVLLGSQSRGDAHEHSDVDLVALGSGPEYTHRQLGGLLMSVSWRTGDAVRVSFADPKLAGSTVPGWRGAVILHDAEGTANELVAEAGAWRWSDIEGPRRAWIAGQMTGRAEVVQRLVGSLAAGRRTSAAVTRNRLATRLPVVAAVHHRILYDSEHRLFDLVADAMGPSWRRSQDAALGLRGEQLPDSCRAALGLYAQLAPVVEPYLTPDQQAVVRSAAELAWAAQHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0E5</accession>
    <name>A0A010Z0E5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CryarDRAFT_2018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850056.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1983"/>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_11"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="12"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="418" mass="43771" checksum="3F995CA7804A7A1E" modified="2014-06-11" version="1">MTLNQPPTPHLAAEDPDVARLVEAEAQRQQDTIRLIASENYVSAAVLEATGSVFTNKYSEGYAGKRYYEGQQLVDPLEELAIARAKAVFGAEHVNVQPYSGSPANLAIYLAVLKPGETVLGMGLPSGGHLTHGWSVSATGKWFNAVHYGVRKETGRVDLDEVRDLALRERPKLIFCGGTAVPRTIDFAGFAAIAKEVGAVLAADVAHIAGLIAGGAHPSPVGHADIISTTTHKTLRGPRGAMLMSTEEWAKPLDKAVFPGLQGGPHNHTTAAIAVALKEAATPEFSAYAHQIVANASALADALLERGFDLVSGGTDNHLILADLSPKGIGGKPAAKALDRAGIELNYNTVPFDPRKPFDPSGIRIGTAAVTTRGLGTAEMPLIADFIDRAVAAEGDEPALDAIAAEVRALLASFPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0E9</accession>
    <name>A0A010Z0E9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="14" type="ORF">CryarDRAFT_2023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1988"/>
    <dbReference type="HOGENOM" id="CLU_040933_0_1_11"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="13">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="382" mass="40344" checksum="C8F44FA02EE3D37A" modified="2014-06-11" version="1">MADMTDTATPLGGTPRSAVDPGSDAAARQVTGRAPVPAELADGPFLRACRRESVTHTPVWFMRQAGRSLPEYRKLREGIGMLDSCRRADLVTEITLQPIRRHHVDAAIFFSDIVVPLIAVGVGLDIVAGVGPVVDEPFGSAADLERLRPLEPDDVPYVTEAIGTLAGELGATPLIGFAGAPFTLASYLVEGGPSRTHARTKALMYGEPELWHALCDRLATISSAFLRVQVAAGASAVQLFDSWAGALSEADYRTYVQPHSARVLAEVGATGVPRIHFGVGTAELLPAMGEAGADVVGVDWRTPLATASDRIGPDRAVQGNLDPAVLLADERVVAEHVARVLADGASAPGHIFNLGHGVLPETDPGVLTRVVELVHEHSRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z231</accession>
    <name>A0A010Z231_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850817.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2562"/>
    <dbReference type="HOGENOM" id="CLU_968803_0_0_11"/>
    <dbReference type="OrthoDB" id="1622947at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="31561" checksum="95827BB691774A41" modified="2014-06-11" version="1">MRLDEELSFAMRSRVAGERLDGAALVAAAERAHRRRRTARRGAVFAAGGLTLAAAVTGVVALSGTPTAVTPTAPPPAEVAVRPVSYVVARASDAIDRNKSKVTYVRTHTTANGETRDEEEWWDGATGDWRRHGDGVDAAITTDGTRDKFLVIDHTTRTWWAVTYPATDQQGSWSKQDVQAALQEKGKFVLVGEESLDGRATLHLRADPAKRDRTELDLWVDASTYDLVRTVSRLKPSGTPDVIVSTYDYTFVPRSAEELERFRLEPPADYRRDQSDAPQKSGVEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z487</accession>
    <name>A0A010Z487_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of various ABC-type transport systems with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851842.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3313"/>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_11"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="272"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="314"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="531" mass="57130" checksum="7FF2243C19A758F8" modified="2014-06-11" version="1">MTALLTVENLSIRFGATHAVDDLSFTLEPGAALGIVGESGSGKSATALALLGLHTDARVTGRIVYRDVDLVAADPSTLRALRGAEIAMVFQDPLSALSPFHSVGHQIAEVYRLHTGASAKQARARAVEVLDQVHIPDAARRARAHPHEFSGGMRQRALIAMALACRPRLIVADEPTTALDVTVQAQILDLLDEVRATTSAALVLISHDLGVVAGSADEVVVMRAGCEVEQGPVDEVLVRPTAPYTRELVAAVPSTADGGPRNANEQGGRALMRLEGVTKVYPLPRRGLRRVEGMRAVDDVTLDVHEGETLGLVGESGTGKSTLARIMAGLVSPTDGTRSFDGPPGAIQMVFQDSLSSLNPRRTIGDSITEPLRLIKAANARERVDYLLERVGLTAAAYDRYPHELSGGMRQRVGIARALAPHPRLILCDEPVSSLDVTTQAQVLALLNDIRREDGLTLVFVSHDLAVVRRVADRIAVMHAGRIVELGDAERVYTAPEHDYTRALLAAMPVTDPVEARRRRELRRRTLINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4B7</accession>
    <name>A0A010Z4B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851889.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3342"/>
    <dbReference type="HOGENOM" id="CLU_022256_1_1_11"/>
    <dbReference type="OrthoDB" id="1653347at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="344" mass="36586" checksum="C2A26ED432AC9687" modified="2014-06-11" version="1">MAYPHLAVEISGPGAHPAAAGPPGAAFDPDELTRVARLADDAGFALVTLDDSAQPSGGGIEAGVRAAYLALRTQTIGLAPALHVTTTEPFHLATQLASLDIATHGRAAWLVSAQNSAAALATVGREPLAVEALREEVRDVIEVGRQLWDSWEDDAIIKDVATGQFLDPDRVHHINFVGDTFSVIGPLITPRPPQGQVVVLGADTLGVTGQLDIALVDGIDLERQVSRARRDGAPRVFAELDVLLGTDESAQTRLEALDARTPWGPPTRLRHVGSPEALRDLLRRLAEHVDGVRLHPAVLDVDLPGLVEQLNGLGPLRGATLRETLRLPRPINRFATSSREVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4J5</accession>
    <name>A0A010Z4J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3387"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="854"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="924" mass="99917" checksum="87A3F9CDC526C729" modified="2014-06-11" version="1">MTVSANVPAKRAGLVGRDDECRVLDDVLEAVRAGESRALVVHGEPGIGKSALLQALVNKAGDLRILATVGMPSEAELPYAGLHQLFGTMTDRIDRLPVPQRNALRVAFGLQEGDSPDRYVVSLGVLGLLADLSRECPVLCVVDDEQWMDRETVLTLTFVARRMKSEAAAVVFASREGREEFQGLPTLVLTGISARHARELLDSVMAGPLDPSVRRQIVTETHGNPLALLDVARGVGPAELAGGFRFPGAVPLSPQVERGYRQRLDALPPAARQFLLLAAADPVGDPTTLWSAADRLGLELSAVTPALASGLISLGARVEFRDPLARSAVYRAAGLVARREVHEALAAVTDPSSDPDRRAWHRAHAADSPDEDTAVELEQSAGHARARGGLAAAAAFLERAAELTADPSTRTRRLIAAAEATRDAGGHEAALFLLDTASMRPLADEQAARVMRIRGIIAIEQHRRADGVELLLGAAARFGPDHAEEARATALEALAGTFWDARQNDPLFAKAAASVADIVRRSGDPSTFTDLLLEGLYVRIVDGFVAAVPLLRRAVDLLVTAAPTDRWPVFGVNRLLLMLAEELWDEEAMGVLATRQVVVCRRDGALAALQQALNYSAFHRMHEGDFLAAGALIEESLAVAAVSTGRTNRHVEVVLSAWRGDEIRTPKLSAEVRQQVLDGRATFGFCADYADAVLSNALGRFDVALEAGKRAFDSDQRIVASMVVSEIIDAASRTGDLNELRSIRDWLAERVAATPRAWNFGLHERCLALLRDDDRAEDHYLESIAQLSTTRGQLEIARSQLLFGEWLRRKGRRGDARRYLRKAHQTFHALGSVGFAGRAARELQATGDVTTRAAERRHPSLTAQEAQIAALASAGLTNPEIGARLFISRRTVQYHLRKVFMKLDITSRAQLTQALPPEAAALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z567</accession>
    <name>A0A010Z567_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570550.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3648"/>
    <dbReference type="HOGENOM" id="CLU_007415_3_0_11"/>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="912" mass="91343" checksum="E99B1FC11B423945" modified="2014-06-11" version="1">MSDVEALLAGGSVVLVRPVVPADADGLRHLHVDASGSNRRMRFFTVGDVTAAAYAEHLAHPDDDHLALVAVRDGEILGVASAEPTGTDPAVAEVALMVTDRLHHAGIGTLLLEHLAAASRRAGVTRFTADVLSENRAMMTVFADAGFTVSMARPEASTVGVSVDLTGTTMLAAAVADRERRAGAASLAPVLAPTSIVVVGAGRNPGGVGRAVVTNVLAGGFTGRLAVVNPHVAPGATIGDVPAYPSVADVPGAAVPGSAGPAATAVASPIDLAVVAVPADKVAAALGECGRAGVRAAVVLSSGFAETGGRDAERELVAIAHRYGMRLVGPNCLGVVNLDPRIRLNATFADLRTSTAPEGAGVGLASQSGALGIAVLEAAARRGIAVSQFLSLGNKADVSGNDALLAWEDAPGVRAIALYLESIGNPRRFRRIAARIAQHKPVVALRSGRSAAGARAGASHTAAAVTPDATATALFRDTGVLAVDTTEELLDVTALLATQPVPAGTRIGVVGNAGGPGALTADAAAAAGARIPELSEATAAALRRLIPRAAAVSNPVDLGAEASPAAYRSALVTVFASGEVDAVVVLHAVTRAQPVSAVVDAVQRVADAHPGIPTAGVLLGAEPPRGATVPWYSFGESAARAVARAGHLAVWRARPHLPAAVPGFDEPAVAALLATAPRSTDGWLDAGAALRLLDLVGVPACRTVPVVGADAAVRAAADLGGPVVVKSAAPGLVHKTDRHAVAVGLASPGDVAAAAAAICRSTGSDALLVQTMATGRLELTAGLVAPAGGVPVVLVGAGGVHEEVLADKALATCPLGTGRAAAMLDELRCAPLLRGHRGSPPLDRGAVVDVLDRLARLAAIAPEIAELDLNPLLVDEHGVTAVDIAVRCHPSTPDGRSLHRDPVADDYARALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5Q0</accession>
    <name>A0A010Z5Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852604.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3835"/>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="117" mass="12637" checksum="A134FD18931C460C" modified="2014-06-11" version="1">MTSLAAVDDDLWSAIGDPTRRRMLDLLLADGGGTATSLGHRLPVTRQAVAKHLGVLDRAGLVRSTPAGRERRYRVDDAQLARAVAQLTAVGTAWDARLHRIKQIAEAIQRGATDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z644</accession>
    <name>A0A010Z644_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852687.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_5_1_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458084" evidence="1">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="320" mass="32936" checksum="112CE38872E416D2" modified="2014-06-11" version="1">MNRRRFGLAAALTVLTLAATACGDGGTDTASGPATIKVTSFGCEIWNTWAEAKGVFAKHDLKVELVKSTGGSAAVAAVLSGAADLGYVNGFSAINAYNTGFPIEIVAGANTNALPPAKPAQGVFVGTNSPLKTAKDLAGKTIAVNELNGLNQIVTSTWLKQNGVDVSGVRFVALPFSDQVPALLSGKVDAAQLGYSLLGDNNGKVRSLADPFATAGTVYIATYVASKAFVAKGDTASRFHDAMVETMAALGEPANTDESFALLSACNKVPADVLKAQPQNALSPSVDLTALNAMADQMVEQKILPKKPDLDAFVPGFARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6K5</accession>
    <name>A0A010Z6K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4116"/>
    <dbReference type="HOGENOM" id="CLU_017584_9_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24650" checksum="81B7F4FAE7BEC8D9" modified="2014-06-11" version="1">MGELSLTDDAITRIRGLIQSGELVPGSRLPPENQLAAELGISRNSMREAVKALQFARVLDARPGDGTYVTSLAPHLLLAGLGSAVDLLRDDTLLEVMEIRSMLEPAATSAAALRITPDQLAELEFLLGQMRAAASDAEELVRYDMDFHRTVVAATGNQSLTSVLDGLSGRTARARVWRGLLSADAAANTLAEHQAIYDALASGDPELARAAALLHVSSSARWLKQALEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLR0</accession>
    <name>A0A010ZLR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.626"/>
    <dbReference type="HOGENOM" id="CLU_005108_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="539"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="682" mass="71482" checksum="09B6184C133F9066" modified="2014-06-11" version="1">MTTRLESSGATHTAEPDPPGWRRLVGPRSKFLVLVFWLVLAGVAAPLAISLTTVQDNDSLTSAPHSSEAYRAQQRVEQAFPNADALVAVAVYARDGGLTDADRAAVEADRASFVRYAIDRTVPPAAPSEDGQALLLSFPLRGDSDEQSDATSDIRDALDAGKPAGLDTALTGSAGADSDIFDAFDGMDVMLVLVTAGVVAILLLVTYRSPVLWLIPLLTVAVASQVASAVVYLLAENAGLSVDLQAQNVLTILVFGAGTDYALLLISRYREELRRHEDRHRAMAVALRRSFPAILASAGTVSLALLCLVFADLNGTRSLGPVAALGIGAAFVAMVTLLPALLVVCGRWLFWPFVPRVGDTTGDSRVWSAVARFVGRRPARVWVSTAVVLAGIAVGASTLSLGIPADETFTDEVGSVTGQRLVAEHYPAGTSAPADIVVDAGRAPDAAAAARGVEGVTAVGAPQVSGDTALISATLTDPPDSRAAQDTIERLRDAVDGTGALVGGQTAGQLDTERATDRDHRLLMPLILGVVFVILVVLLRALVAPLLLILSVVLSYAAALGAAAGVLHLLGYPRLEYSIVLTTFLFLVALGVDYTIFLMTRAREERSVPRALVSTGTVITSAGVVLAATFSALCVLPLTPSLQLGVIVAVGVLIDTFVVRSLLVPALALHTGRRFWWPSRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMG4</accession>
    <name>A0A010ZMG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restriction endonuclease S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_6_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="402" mass="45174" checksum="DA7812F31EA9E5A8" modified="2014-06-11" version="1">MSQVADLIQQHVPDGVEYKTLGELGTWTGGITPSKANPKYWDRGTVPWVTSMDISATGGSEIRGLVTEAALRETSLRLVAGPSIAVVMRSNILRRFLPIGYIDIDTSANQDLRLLTPVDGIDSRYVFWALQADSERIRQACVRTDGSMAAVNSKAFFEWRIPVPPLVVQRNLVTIFDAFNELEGCLQAEMGLRREQQVAVVSNQLATQGTVDRVALGNVATQVIEPVKVEPNVQYVNLGVKWYGEGAFAREPKYGRDIKAKTLYKVRPGQFIYNRMFVTEGSFGIVTPEIAHGVVSNEFPVFELDASRILPEWLYLKFRDPYIVSVVAGQASGGTKSRRRWKEEQFNAFVIDLPPLDVQREMVRIDSAFRDLRQAINAELVSRQQQFAYYRDRFLAFEEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNR5</accession>
    <name>A0A010ZNR5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CryarDRAFT_1390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569853.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1364"/>
    <dbReference type="HOGENOM" id="CLU_011276_1_0_11"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="14">
        <location>
            <begin position="164"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG80319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="42594" checksum="CE71D088013C6475" modified="2014-06-11" version="1">MTYPVGLRLTGRRVLVVGGGTVAQRRVPALLDAGAQIVLVAPEVTPALDALAAAGRLRWEPREYTAGDVDGAWYVMAATDVPAVNAAVAEAAEAAHTFCARADDGSDASAWTPAVGRHGNLTVAVHADRDPRRAALLRDALVDRLNDGSLDAAPQRGRGPVPGVALVGAGPGDPELITVRGRRLLSQAEVVVADRLAPQLLLDELPPHVEVVDASKVPYGRAMAQEAINETLVSRAKAGRFVVRLKGGDPFVFGRGSEELEACLAAGVPVEVVPGVTSAVAVPSSAWIPVTHRGVAHELVVVSGHVAPEDPRSLVDWSALARLKGTLVILMGVERLPAITAALIAHGRAADTPAAVIQEGTTGSQRQVLATLGTVASDALAAGLSHPAICVVGEVVTIGARLTALASALPASVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZP57</accession>
    <name>A0A010ZP57_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040273_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="269" mass="28372" checksum="097CD47A007A71CD" modified="2014-06-11" version="1">MAAIRPRRSGTRSPRHRAGRPNASRSGNALGWRIALPCVLLLAGVLFAASAETSQGSDLRGGRRDQLAELIRRGNTEVATSERRAAELRRSVDEATRSRTRTDARLKGPQREVDSLTGPAGLGKVRGPSLTVKLDDAPRRPGGVLPAGANADDVVVHQQDVQAVVNALWAGGAEAMTIMGIRVISTSAVRCVGNTLLLHGRTFSPAFVITAIGNVSSMRDALDTSPGVSLFRQAASAWNLGYTVGDPQVVTLPAYEGPTGLTHATSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPR1</accession>
    <name>A0A010ZPR1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569938.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1718"/>
    <dbReference type="HOGENOM" id="CLU_634269_0_0_11"/>
    <dbReference type="OrthoDB" id="577862at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="164"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="463" mass="50458" checksum="8149EE9CB8AEA84D" modified="2014-06-11" version="1">MTLRAVRRAITAGFLATVLLFGGLVGDERLETRRPLGLDPTQLTPRDDRLARELLAAVNERSFVDLVDVRFLGLPLPPVFGLVPNVDTTVIELDASGRPVAAATVLLSARFRDGLIIPLDENLTTDAVRWRRWDDTAWSGNAGQGSVDLHPGHTGAPVDFMSPYPASVFKLMVTFGVLRLVDQGRVELDEPYTYAPDGEPSPICEGARTAPVRTFLDEMLTISSNPSACAMVRLLHQHRAIPRFDDLGLPTLRLGGTDPRTGGNWTNEITMTSPDTAKLLLLLVGGPGTLWRTPEGKPVTRDVLRPASRAFFLRTLGEQGLNQVLSTTNWCDRPYPAAGIPQLTPVRWTDPTDGTVRLPEHRYGEDVRPCNEAAEVTFAHKTGLAETAGGDAGIVRSLPGKPWRHYIVVVQTNLGSRFVDPARPKDPPGVDPVEYSEKFGELGRAIDVAVTAHHYAGTVTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPR7</accession>
    <name>A0A010ZPR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847718.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.222"/>
    <dbReference type="HOGENOM" id="CLU_083309_0_0_11"/>
    <dbReference type="OrthoDB" id="705269at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="28472" checksum="ED292EA2D1E36DA6" modified="2014-06-11" version="1">MTRRPAVGELLRGWRERRRLTQLSLSLQADVSARHLSFIETGRSRPTSEMILRLCDELDVPLRERNALLLAGGYAPAFPDHGLDDPSLDAVRSALRQVLEGHEPHPAVVIDKNWNLVEANSGLALFADSVEPSLLEPPINVLRLSLHPGGMAPRVVNLGEWRAHLLTRLERQVAGTGDRAAAELLAELTAYPGGLDREAEPQPHDVVVPLRYRHQEHELSFLSMTAVFGTPLDVTVAELAIESFYPADAATAKFLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ74</accession>
    <name>A0A010ZQ74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849890.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1867"/>
    <dbReference type="HOGENOM" id="CLU_045498_7_0_11"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="25308" checksum="EE991A061EB92151" modified="2014-06-11" version="1">MHLSLPAIGLLVVAGLAAGIVNGIAGGGSLLTFPALLAAGLPPVSANVTNSVSVAPGYLSSVYGSRRELAGQKRRAWTLVPIAVVGAGIGCVLLLITPGDIFEYIVPFLVLGATAVLAFQDQLKGLARRGRTTTMVGLTFVGSAYGGYFGAALGVVLVAVLALVIDETLQRVNALKNVLSATVGLVTVAVYALFGPVSWLGVAVTAPATIVGGYLGAKLAKKLSAQALKITVVVFGTVIGLVLLYRAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ82</accession>
    <name>A0A010ZQ82_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849906.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_1_2_11"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="22546" checksum="53CB626A01713553" modified="2014-06-11" version="1">MPRDVEATKRRIRDAALREFAEHGLHGTTVERIAVRAKANKERIYSYFGDKNALFLSVIAEELDKVAAAIPVRVERTEDFGEMAGRTFDYLREDPGLQRLMLWEGLADTGAVADEANRGLHYREKTEAIRVAQQRGLLDDTLEPHHLMFFLLALANWWFAAPQMARMLTGGPIDEDEWAGRRRAVVAAANRLCRPDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQC5</accession>
    <name>A0A010ZQC5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_0442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569615.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.426"/>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="417"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="459" mass="50214" checksum="05A28E03ACB34A1D" modified="2014-06-11" version="1">MTGPDQFPQFPPGFVWGVATASYQIEGAVTEDGRGPSVWDTFSHTPGRTHDGDTGDVADDHYHRYPEDLDLMAGLGVNAYRFSIAWPRIQPTGEGPVNPAGLAFYDRLVDAMLAKGITPAATLYHWDLPQALEDKGGWTQRDIPHYFAEYTAAVADKLGDRVGLWCTLNEPFIVTAFGYVLGVHAPGRQLFTDAFAVAHHQLLGHGLAVEALRAANVTGTIGVVNALAPVHPDSDDPADHVAAGILDTLMNRTYTDPLLLGRYPEETPAVYAGADLSVVKDGDLSTISTPIDFFGVNFYNPHRVRAAAPEQFGTGPLNFETVEYPGVPTTAMGWPVVPEAFTELLTGLHERYGEKLPPIYITENGAAYDDEPGPDGRVRDDDRIAYLDRHLRAVHAAMAAGADVRGYFCWSFLDNFEWAEGYQKRFGLVRVDYETLERTPKASYDWYRSVIALAAAVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQP1</accession>
    <name>A0A010ZQP1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="11" type="ORF">CryarDRAFT_0573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.560"/>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_11"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="9">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="10">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="69"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG79532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="219" mass="24745" checksum="48CF03DC1736A9CD" modified="2014-06-11" version="1">MEREYGVVSQVGGMRVGYERGTLTESTLADNWFDQFTRWFDEAAAADEIAEPNAMIVATAAANGTPSARTVLLKDADERGLTFYTHYTSRKGRELTENPRATLLFPWHPLQRQVNVAGTVHRVDPAESDAYWNSRPHGSQLGSAASPQSRVVPDRAALEDAEKTLAERYPDAVPRPETWGGFRVVPHTVEFWQGRPDRLHDRLRYRRDGELWVVERLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQU5</accession>
    <name>A0A010ZQU5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type spermidine/putrescine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848321.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.610"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="36047" checksum="81D928FA29E2EDF7" modified="2014-06-11" version="1">MTGVEVALAGLRRTFGTVHALDGLDLTLTPGELVALLGPSGCGKTTALRVLAGLEDADAGTVTVGGKDLTRVSANKRNMGMVFQAYSLFPHLTAAENVAFGLRLRKLGGAERTKRANDALELVGLTAQAGRYPHEMSGGQQQRVALARALAIRPAVLLLDEPLSALDAKVRVQLRDEIRRIQLEVGTTTLFVTHDQEEALAVADRVGVMRAGNLEQIGPPEEVYSRPATAFVAEFVGLSNRLPGVVAAGGTVEVLGQKLPLAQSDATTPGAEVTAYVRPEAVEVAVDPASEARVASSAFLGSSSRVTVTMPGGELITAQVPSSQVSELAPGTAVRVTFARTPVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQU6</accession>
    <name>A0A010ZQU6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase component of ABC transporters with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850193.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2110"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="344"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="545" mass="58735" checksum="C000048B83623126" modified="2014-06-11" version="1">MSATLVVKGLSAGHGDRTLFSGLDLVVAPGDVIGVVGANGAGKSTLLRLLAGLDTPQQGTVRRTPATATVGYLPQESERRPGESVRDFLGRRTGVTRAQQDLDEATEALSEGKPGADDAYSDAFDRWLALGGADLAERADTVADDLGLSIDLDARMAGLSGGQAARASLASLLLSRYDVVLLDEPTNDLDLDGLERLERFVAELRTGTVLVSHDREFLARTVTSVVELDLAQQQINTFGGGYAAYLEERETARRHAREAYDEYAGTRAGLVDRARTQRSWMEKGVKNARRKAPDNDKIGRKFRTEATEKQAAKARQTERLIERLEVVEEPRKEWELRMTIAAAPRSGAVVATLRGVVVRRGDFTLGPVNLQLDWADRAVLTGANGSGKSTLLGVLLGRIEPDEGTAALGPGVVVGEVDQARGLFAGDDTILDVFARVLPDQVPGEIRTLLAKFGLKADHVRRPAGSLSPGERTRAGLALLQARGVNLLVLDEPTNHLDLPAIEQLESALENYPGTLLLVTHDRRMLDAVSTNRRFHAVDGQVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR88</accession>
    <name>A0A010ZR88_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.748"/>
    <dbReference type="HOGENOM" id="CLU_036699_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020043">
        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="PTHR42717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039004">
        <property type="entry name" value="ADE_EF_0837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR039004-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="386" mass="40788" checksum="6899AD592DFAA92C" modified="2014-06-11" version="1">MSENLYDTVVRGGTVLDHASGLNQVADLAIKDGKVAAIGDDLARSAANVVDATGATVLPGLVEGHTHIFEKVSKVGAPQDEAHLRRGVVAAADAGTAGASTFPAFRTLVVEPTVMRIVNFLNVSVLGLIDFRYGELLNPDTFNVDDALATAAENPDVVRGFKIRLSEDVLGDKIVPLLEKAINLGEQAGLPVMVHIGETALTLPEILDRLRPGDIIAHCYTGKENGILDENGAVLREVYKARERGVMYDSAHGKSNMSFKVAKPAIAEGFLPDILSSDTSGRNWRGPVFDLVTSMSKFLALGVPMSEILPRVTTVPAKYLGLDVEGYGSLTVGGPAHVTVLKEVGATVLPDAAGNTIEAPRLEPTAVFVNGVSHELTEWRGNAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRP6</accession>
    <name>A0A010ZRP6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810661_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="36003" checksum="DD2BEF4D8DC08690" modified="2014-06-11" version="1">MPSSVLLALVVAAGVLILMPALAHRYDTALRGQAELRASSMRVLPRERRRRTVPSGGPVRPPTSLVVPAAVKTAQGVSADGRDLTAVRASLVREALQESGTSRGRVRVRRPANVDRPTSAVPVSAVPVSAPAASPVSVVPAPRTAPAVVSAAAVRRAAELQRARRRRLVLVLALLVAGQAVAGLFFGASFWIGAVVSAVVAVGLLGRLRAVAAQRQQREAKERQAQVLIARARQHRAEAFVRRALRQVPAGAEREAWLGPEAVHQAAGWLSLSRAERERPARDVVRVLAAAGREVYLAADGSWAVRPVSRPAARTRDAAGATPAARRQARAAGAALPKVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRS9</accession>
    <name>A0A010ZRS9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ORF">CryarDRAFT_2455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2418"/>
    <dbReference type="HOGENOM" id="CLU_015485_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="11">
        <location>
            <begin position="119"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="770" mass="80082" checksum="844E1F33C02BBAB0" modified="2014-06-11" version="1">MTLLDMEPAEPEGTAGSARPGAKRAAPRRAPARTEDTALPLDLAPAPGEPPPVEESAPAESAPAESAPAEAAPAEAAPAEAAPAEAAPAEAGAKPAKKKRAAKPKGAREPAAELPVARICVDLPLPHLDRPFDYLVPSDLADTAVVGGRVRVRFAGQLVDGYVLDRVATTEHTGKLAYLEKALSAEPVVSPEIARLARTVADRSAGTLADVLRLAVPPRHARAEAARRGDGVLPVDEQGRHRPPADGFARYRGGAAYLRLLAEGGSPRAVLAALPGEDWPRRVAEAVAATLASGRGAVAVVPDARDLERLDGALGDVLGSGRHTTLAASLGPEERYRRWLAVRRGEVLAVAGTRATAFAPVHDLGLAVLWDDGDDLHAEPRAPYCHARDVLLVRSQLAGAGLLLGGYARTAETQLLLETGWAKPLEADREVVRAAAPRVVPVGDDRDLAADPTASAARLPTVAWRAAREALAADAPVLVQVPRRGYVPSVACGRCRRPARCTTCSGPLELRGSGTDDVPACRWCGHLAGDWTCPECGHRGLRASILGARRTAEELGRAFPGVTVRTSGRDGVLGSVGPGAALVIATPGAEPVAEGGYGAALLLDTWALLTRADLRASEEALRRWANAVALVRPARAGGRVVIAADGAIPVIQALLRWDPGWHAGRELADRAELGFPPAVKMASATGTPDAVADFVRLADLPPEAEVLGPVPVAAPPRAGAEGEELERALIRVPRSLGPALATALHAAASVRSAHKAPQPVRVEMDPLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRV4</accession>
    <name>A0A010ZRV4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1394293_0_0_11"/>
    <dbReference type="OrthoDB" id="1693549at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458259" evidence="2">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="195" mass="20776" checksum="5C840C70D0FB7259" modified="2014-06-11" version="1">MVFRRLLAVAAVPLLLIGLSSCQSDPTVAAYVGSDEITVDQIDGYFDQAAQDPLSSELVAQNRAEVKPRLVSMLVFIELLREAAKDAGVPVTAGEVAQVKAQIEPQRQMVTGDLALLPLDQMAEFQAHRLKLSQWASQGAASQGAAEKKYSDAVQAAEGDNPVTVNPRYGKFDLEKVPQLGSSDSAVKPASPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS00</accession>
    <name>A0A010ZS00_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1028"/>
    <dbReference type="HOGENOM" id="CLU_037015_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="41359" checksum="BD1293C2BA207E19" modified="2014-06-11" version="1">MIPTAAPVTGARSPWRFRVILTVVLLALVTLAVWLLVSTQSSSERAALDPDAANPGGTRALSVLLGDDDRPVTELTTTDDAMKRAAAGNVTVVVPFPYNLGGASLRRLAELPDTVRVVFVQADPFALDDLELDVRIDSAGVTETREPDCSLPEATSAGSADIGGYSYTGEGLTRCYDGHLAVLDRPARAELVFLGSGDPFTNKVLAEHGNAALSLGLLNAHADVIWLQRVSPEPIAKAEARSLSDLLPRWIPTALWMLAAAGLLAAFWRGRRLSAPVAEPLPVIVRSTETVEGRARLYRRARARPEAAEALRGAALARLRPVLGVNAHSDPREICEAIAERSGWPAAAVGQHLYGPPPTDDHGLVVHADALDALTAAVLTPKPHSEGQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS65</accession>
    <name>A0A010ZS65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
            <ecNumber evidence="3">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850859.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2594"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_4_11"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="25963" checksum="4EDCFCE4DD2DDC31" modified="2014-06-11" version="1">MSDEVQVEHADGVSIITINRPKARNAINGAVSAGISAALDELDERDDLTLGIITGAGGSFCAGMDLKAFVAGENPSDEKRGFGGITALPPRKPVIAAVEGWALAGGCEVALACDLIVAAEDAKFGIPEVKRGLVAAAGGLVRLPRRIPPAVAMELALTGDPLSAADAHKYGLVNSLTPSGGALEGAKALAARIAANGPLAVAASKQLIVQSQDWTDAELWQKQGAIVGPVMASEDAREGSIAFAEKRAPVWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS86</accession>
    <name>A0A010ZS86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850907.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2619"/>
    <dbReference type="HOGENOM" id="CLU_007415_2_2_11"/>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="707" mass="73928" checksum="D69B8F5C179CA95A" modified="2014-06-11" version="1">MAYDTDAVRRVLDAAKGRDSLTAPEGRAVVEAYGIRTPGEGLATNPEDAVAVATAIGFPVVLKIVSPDILHKTEAGGVIVGVADGAAAADAYRTIVRNAREYDADARIVGVQVQEQLTSGHEVIVGAVTDPTFGKIVAFGLGGVLVEVLKDVTFRLAPTSLETARSMVDGIKAAEILRGVRGAEPADPEALADLITKVSDLVTDFPEIAEVDLNPVLATSTGATAVDVRILVDPAAAKTPVRFGRDEILASMNRIMRPAAVAVIGASGEDGKIGNSVMKNLVNGGYRGRIHPVNPKAADILGLPAVKSITDVPGDVDVAIFAIPAKFVPQALEEAGAKGVAGAILIPSGFGETGNHDLQDEVVEIARKHGVRILGPNIYGYYYTPEHLSATFCTPYDVPGGVALSSQSGGIGMAILGFSRSAQMGVSAIVGVGNKADIDEDDLLTFFEDDPHTHLIAMHLEDLKDGRAFAETAQRVSKRKPVIVLKAGRTSAGARAAGSHTGALAGDDAVYDDILRESGVVRAPGLNDMLEYARGVPLLPTPQGENVVIITGAGGSGVLLSDACVDNGLSLMHIPGDLDEAFRAFIPPFGAAGNPVDITGGEPPSTYRNTVALGLSDPRIHSLILGYWHTIVTPPMTFAELVVDVVEEFRARGIHKPVVASLSGDVEVEEASEFLYRHGIVAYPYTTEKPVAVLGAKYRWARAAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSJ4</accession>
    <name>A0A010ZSJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urease, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848993.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1239"/>
    <dbReference type="HOGENOM" id="CLU_129707_1_1_11"/>
    <dbReference type="OrthoDB" id="1755809at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="11679" checksum="7D81AB4484A2F42B" modified="2014-06-11" version="1">MTPGEIIVAADAVPLLEGRERRSLEVTNTADRPIQVGSHYHFAAVNTGLSFDRRAAWGYRLAIPSGTAVRFEPGVVREVDLVAIVGTRDIPGLRPEFAGLLDERGPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSW3</accession>
    <name>A0A010ZSW3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2435870_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="90" mass="9818" checksum="A6859EF3C36D61CD" modified="2014-06-11" version="1">MRQATKPMIIGISSPTNIVTKRIEGAVLAGPPRHDVLVMQHYTARLDVTVCDVRTEAEPGAGSFHLVHESEEVVAAPDVADWIVRRYPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT70</accession>
    <name>A0A010ZT70_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein involved in cysteine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2974"/>
    <dbReference type="HOGENOM" id="CLU_070331_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="258" mass="27772" checksum="9D9410D6A37C8DE1" modified="2014-06-11" version="1">MSAVTPRPTAGSEFVWGLRLLGRGFGMYAKYPGLLLLGLIPAVIAFFVLLAAFVTLLVFLDDLGGWIAGSFAGGWSADARKAAELLIEVTIVIGALWLSVIVYTALTLIIGDPFYEKISEEIERRLGAVDHPELPWHKTLPRNAADSIRVIGTQLLLTIPVLLIGLVPFVGQVLAPILALLIGGWLLSLDLTGIPFNRRGVFLKERRRVLRQHRALALGFGIPVAALALVPFANIVVVPAAIAGGTLLTRRVHGQPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTT4</accession>
    <name>A0A010ZTT4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="828" mass="87903" checksum="52E04F93FEE8B497" modified="2014-06-11" version="1">MPAHATCGYGPLEFDRVRTRSDLRGRTAELEALRRLFDGGREGASATLVVHGEAGIGKTALTHTALARFGEGLRVECTVGVESEMELPYAGLHMLLFGLLDRVGSLPEPRRDALEVALGLRAGPVPGPFLIGLSVLVFVMRTIGAVFSRLPELALTGLAEADAKRLLAQLVVAPIDGRIRDQILAEAKGNPLALRELPLGRSPADLAGGFTVNDAMPLATRIENSLLDRISGLRADARQVMLLAAADPTGDPSLLRRAVRALSIDGEAVEEAERTGDLTIDSRVEFRHPLIRSGIYRAVSPPERRRSHAVLAEATIAEDDPDRRAWHRGYATVEPDESVAAELDGSSVRARRRGGVSAAAAFLERAAALSPAPSDRARRMLAAAQAKLDAGAPEAARILLENLPVAALDRRGSGLAGLLLAQADFARSRTPEIAHDILAAARQLAGVDAELTRSAQYGALRVAIAQGGRPDDDADHGPGVDGYPWRDICQEVFDETDPDSTHPVDVLIRGQALIEIGARAEAVPVLRTALAGLLDSPVDLIPPQSIGLEAIAAADVWDVQTLLALCQRQIVSARSEGLLTALPIILSYAGTACLNLGRLDKAELLVDEVDVIGEAIGYTFPPHTRVQLAAWRGDSAEVARHTAELRRGAAATGDGAPLSTAHYAEATLANGLGRYEDAVRAGSVELAHIRQVTFTSRIASELVEAATQTGAEDHHHCEAIERLGRGGLAAHQGRARLAYGEWLRRQRRRVDAREQLQAAHSVLSSRGAAGFAARAKSALEATGGTVHSRKADPENVLTSQEANVTQSALSVPSVWAHRTVVHAGGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU37</accession>
    <name>A0A010ZU37_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851863.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3320"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="460" mass="46570" checksum="41DA0DA81FA0F737" modified="2014-06-11" version="1">MESSQRTVLRAGRREWVGLAVLALPTLLLALDFSVLFLVLPRLSADLHPSAVQLLWITDAYGFLIAGFLITMGTLGDRIGRRRLLLLGAVLFAGASVFAAYSTGPLMLVAARALMGVAAATLMPSTLALISTLFADPAQRARAISVWVACFMGGAALGPIVGGALLTTFWWGSVFLLGVPVMVLLLVTAPFVLPEHRSQKVGRIDAISVLLSLGAVLPTVYGIKELAGTGGLLPAFTALAVGGAAGSAFVRRQRRLSEPLVDVRLFRSRAFSGGVVGMTLNSAIMGGTALLINLHLQTAVGLSPSEAALWLAPGALAIVVSSLAAPLLVRRLQPADVIAGGMAVAAVGYLLLSRADAAGPILAANVLIGLGAGPITALVTDLIVGSVPATEAGSAAAISETGGDLGIALGVAVLGSLGTTIYTGAAGLTAAGFLAAALAVMIGVLAITTLRSSAPNRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU51</accession>
    <name>A0A010ZU51_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591776_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="167" mass="17458" checksum="3A4A2F8D0CE73219" modified="2014-06-11" version="1">MFPPPGQAGRTASSALSGEDTRHTGFAPEFILRLDGSPGSRIDVVRVDGFDEPVPTGNSPTCAEGIDPHHGRPSRRVSTLPAPPDRPRRGAVRRVTDLAKGLVVLVEGLNPLAAVDPDAFDVATRRTAVRSALERVLARGGYFAGRGSNGPPLAAHTVPSVASALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUH2</accession>
    <name>A0A010ZUH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852025.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3453"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_11"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="33627" checksum="F1049ADF1AA55D5E" modified="2014-06-11" version="1">MILVTGGMGFIGSHTVRALTEAGEECVLLQRRTPQVPPHLADLPIHVVQADVADLDALLDVGRKYPITGIVHLAVALPWPVTDGDPIEATGAALEAFLNIVRAAQAWGVRRVVTASTIGVYGFAYHGALTEDMPISFEHIHPIPTFKKITELLAGHLSDVTDVNVVNARISGTWGPGGHLPDPFFAAPSLAHAAALRAEPDLSGLLAPPKAEDALDLLYVKDTGRALALLQLAEELHHSTYNVGSGRATSNADVVTAIRSVEPGFRCDLPSDGQRPLSWLDITRLREDTTFEPRYDTAAAAADYIAWLRAGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUH9</accession>
    <name>A0A010ZUH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852043.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3465"/>
    <dbReference type="HOGENOM" id="CLU_524516_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="468" mass="50462" checksum="C1C6B4D3C4887CD6" modified="2014-06-11" version="1">MRAGPPDQPDRFELVGSARHGGEGVAWRARFRGDRDDGPWFAVKQLHRPPGVGADWPTAADRQRWQDHRILLASLDVPRLVPMLDFFLAHQGEGDGPGVPHVVMPWISGPTLAEKVADAPITHRNLDERLALVEDLAHALGGLHTRSAASGNSLLHSDVKPSNCVIDPADGLILVDLGGLRLLEEPADERGMHTAGYAAPEVLRDPCAPRSTASDIYALGAVACYCLTGVGPPAASDPGYVNVSRKTLAAGLGALRLPGSEALIDQVLAAMDPDPAARPTDPVVWAARLRRLAALPPARRRPSVTALILALTLSVATVALPARELPARPAAAPAYASREVQITSPRSGQDVQGCQAFVGTSDLPPHRTMVLTRRSASADDRTRWAQPVENWQQPDRLRTWYGYQFFGDASAVGDHFVVEVFVADRAVLLASWQRALRAGEKWKVVGVPPEWQLAAAVTVRRVPGFRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUN5</accession>
    <name>A0A010ZUN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852181.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3548"/>
    <dbReference type="HOGENOM" id="CLU_049557_1_0_11"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="30882" checksum="9F80CCF4A1B5B797" modified="2014-06-11" version="1">MGDKTLALADVAGHVESGMTIGIGGWGSRRKPMALVRQLLRSDVTDLTVVSFGGPDVGLLCAAGKVRRVVYGFVSLDSIPLDPHFRAAREQHGLPVTEYDEGMFVAALRAGASRLSFLPTRAGLESDVMRRNPELRTVASPYDDEVYVAVPGIRLDVALIHLNRGDAAGNGQYLGPDPYFDDVLAMAADRTILSVEKIVSTADLTATAPPQSLLVSRLFTRAVVEAPNGAHFTSCVPDYDRDEAFQRHYVASAGDPDAWRAFAAAYLAGDEDQYQAAVRNHALEGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV12</accession>
    <name>A0A010ZV12_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850191.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="71" mass="7581" checksum="6062A7FB66EFB16D" modified="2014-06-11" version="1">MNDSPTDLSHAHWRKASRSTGANTGCVEVAANFPVVTAVRDSVRPEDGAHVVPRAAFGAFLDDVKAGRYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV21</accession>
    <name>A0A010ZV21_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570009.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_1_11"/>
    <dbReference type="OrthoDB" id="1962095at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="172" mass="18275" checksum="95498B79990BB47B" modified="2014-06-11" version="1">MTALLRWHRARRRTGDEGFTLIELLVVVVIIGVLIAIAVPLYNNYKKGAQNTAAQSDVRNGVTAVEAFYTANGNQYPQSVNGTLGNPLKLTLAGGTPSTKSDADQIAVSAGNQLILKTTNTASGTTQPGYAICGWSSTGKNVYVYKSVTGKTIKYGPDKTTPNIPECKIVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV50</accession>
    <name>A0A010ZV50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852436.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_11"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="480" mass="49788" checksum="E3D4825D7356C882" modified="2014-06-11" version="1">MHLPVPRTWLAGVPGANTAPAVRDLFDPNTGEHLQTYAFSADQQVDAVLDAAVAAHASGRWADADLAERAVVLSAFATRLEGVADTIAELDALNSGVPVRFTRMFAESLPGTVRRAVELAEEQSTRRWLEADGRRVQLRRRAWGPTALLLPWNAPAAVLVKNVAYALVAGAPVVAKPSPESPWSAEIVADALTAAGVPAGVFGLVHGDARVGALIAADPRIQAISMTGSTHSGRSVASAAGRNLTRLRLELGSNNPAVVLADADVPATARALASGFTKLNGQWCEAPRAVYADSGLTGELVDALVAEIEQLRLGPSTSGDTTFGPMAFAGRKSVLEDQVTAMAAPGARSVAPLALPSDGWFLSPTLIVGDEVRLPGEVFGPVLAISPVTGDRRAVARANALGGGLAGYVFTRDVERGLEVGSQIVAGEVKLNGTSLLDMARDSAQSFFGTSGLGGHGDRDVLEFFAGKQVLGADLPDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVL2</accession>
    <name>A0A010ZVL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850496.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2315"/>
    <dbReference type="HOGENOM" id="CLU_027555_0_0_11"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="473" mass="48499" checksum="253CD821F4D4C1C4" modified="2014-06-11" version="1">MSTVEALTSAAAAAAPELDALGRAGRARLLRAAADEIETRRDALIATAARETHLGEARLNGEVTRTAYQLRVFADVLDEGSYLEATIDHAGDTPMGPGPDLRRLLVPLGPVAVFGASNFPLAFSVPGGDTASALAAGCPVVLKAHESHPDTSVSAFEALQAAVAAVGAPAGTVGLVHGREAGAELVTDPRITAVGFTGSLGGGQALRALIETRPEPIPFYGELASLNPLVVTPAAAAARAESIADGLVAAVTGSLGQLCTKPGLIFVPADPGGDALVARMAAALAEVPAGPLLNDRVAEGFATIGTALRSRPGVATAATGTGEGALPALLTVEATHFTADLAEECFGPLALLVRYESEKELVEVLSTLPGSLTGTIHSADGDDLAPLLAVLRPRAGRLLFDAYPTGVLVAWAQTHGGPWPSTNTVHTSVGPTAIRRFLRPLTWQNAPEHVLPEELRDGFRGIPRRVDGVLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVS9</accession>
    <name>A0A010ZVS9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852700.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210195_0_0_11"/>
    <dbReference type="OrthoDB" id="1198550at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="62" mass="6953" checksum="691030B031443292" modified="2014-06-11" version="1">MIRTIGQLADRLLSAVAPRTTAMAGYEYKCESCGSPYTRLDWRYCSSGCSPWYRGECKFAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVV5</accession>
    <name>A0A010ZVV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852744.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3968"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="255" mass="26373" checksum="75BD7805C86C9766" modified="2014-06-11" version="1">MTVLDTFALPGKVAVVTGGNRGLGRAFAHALGEAGASVAILARDAEASARVVAELAASNVRAAAFTADMADRAAVFAAAEEITAAFGPVDVLVNNAGTCIHRPALEVTEADWHEVISVNLTGVWYGCQAFGAGMVRAGGGVIVNVGSMSGEIVNRPQWQPAYNASKAGVHHLTKSLAAEWAPHGVRVNAVAPGYVRTDMTPIDRPEFAAHWIGDAPMRRAAEPHEIAPAVVFLASPASSFMTGSVLVVDGGYTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY68</accession>
    <name>A0A010ZY68_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3258"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="31651" checksum="9DAE407AAD6A962F" modified="2014-06-11" version="1">MAMIDVTGLTKRYGSTTVVDDLSFTVRAGQVTGFLGPNGAGKTTTMRMIVRLAAPDGGSVTIDGRRYSDLPTPLTEVGTLLDAGAVHGARKAYDHLLALAVSNGLPRRRVDEVLARTGMDSAARKRAGEFSLGMRQRLGIAAALLGDPPVLIFDEPVNGLDPEGIRWVRELMRSLAAEGRGVLVSSHLMSEMAQTADHLVVVGRGKLIADTPMSDFMRAAGGGTVQVRVDDPGALALRLTAAGATVRNGLESSLVVSGVTAGEIGAAAAGLGLVLSELTPQRASLEDAFMELTSDSVEYQGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYK6</accession>
    <name>A0A010ZYK6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851947.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452198_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="18940" checksum="85D78DE12939A5D5" modified="2014-06-11" version="1">MGLAPITLGMVGLAFALWGNGLANLRGTADVKSVAVSASLLGAVTLLFMSAHLIVAAPLGTEGPAVRLQLLFSAITGMYGLQFLATTIVQLKGYDPRPLGDLALVTVPVQIVEMVLLARFADAAGMSVTHIVLQEVVLGAFAVAGLAIWAGTHGRLGGRAVGGAILAAFVGTLYFLFFAGGLIAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYS2</accession>
    <name>A0A010ZYS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570469.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011036_0_0_11"/>
    <dbReference type="OrthoDB" id="2002412at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="259" mass="27000" checksum="178D92DE492B03E8" modified="2014-06-11" version="1">MTALLASARYEFAMQIHKISLWIAPLVLAGALVVLQGERGPLRAGDTMDGRQVMASWALLFGFLVPIAAGMVLADRGVRDHRLHVEPILASLPASFGTRLTGKYLGSVAATAAPPLLALLAAGCYEAVSRGEPLVVGWALVAFVLVTLPGLLFVGGFALVCPPLISAPLFRVLFLGYWFWGNLTFPKLMPTLSGTPLAPIGDYAASWLMGTPALYTAAGGVLRPDVSAATAALSVALLVVGGLLPLFIGAGLRARAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ32</accession>
    <name>A0A010ZZ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852289.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3628"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="351" mass="36545" checksum="EB30A089C5A37DB9" modified="2014-06-11" version="1">MKAAIFHDRKTITIDDVPAPELRPGAVAIDVAWCGICGTDLHEYLEGPIFIPPAGHPHPLTGEAQPVTMGHEFSGTVTALGEGVTGLEVGDSVVVEPYVVCGDCAPCAAGNYNLCTRMGFIGLAGGGGGLSEKVVVDERWVHPVGDIPLDQAALIEPLAVGHHAFVRSGARAGDVAFVGGAGPIGLLLAAVLKAEGLTVIISELSDARKTMARTTGVADHVLDPAAEDVVARVRELTGGVGADVAFECTSVNAVLDQLFDAVKPAGVVVNVSIWGAPATIDMQKVVLKEIDLRGTIAYVNDHPATIKLVQDGKVDLAPFITARIQLDELLEKGIDTLINHNDTAVKILVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZB5</accession>
    <name>A0A010ZZB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852428.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087858_0_0_11"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="257" mass="29075" checksum="129779CA67B6137C" modified="2014-06-11" version="1">MDGHQPGDALNRPSHPTASLPEVRARTEISRLLTETPIPPEDLTKNLGLYQSKESVATILAMNDVYRRIRSIPGVIMEFGSLWGRRLALLIALREIYEPYDYTRRIIGFDTFTGLPDLHRNDGSSVEVRPGSMSVPPDYARHLEQVLHVHEMESCHAHIQRFEVRQGDVRRTLPEYLTSNPETIVSLAYFDLDLYEPTIACLEALRPRLVPGSVLAFDQLVHRNFPGETIAVLESLGLRLKSVEKLPYLRSPSIVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A087</accession>
    <name>A0A011A087_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852962.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4078"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_11"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="35724" checksum="2F94EA12DE41DD4E" modified="2014-06-11" version="1">MTSAALAGWFAENDIPLEGEPELALIAGGHSNLTYRVNDTYVLRRPPRGHVLPSAHDVGREHRVIRALEPTAVPVPHSFGLCGDATVLGAPFYVMDLVPGTVVAGHDDGAAYPADARGPACRDLVGVLAAIHDVDVDAAGLGELGRRADYSARQLRRWKRQFHAASTRELPLVDEVHDRLVSAIPPQRRTGLVHGDYRPGNVLLAADGRVNAVLDWELATLGDTMADLGWLTATWREPGEEELIESPAANPGFWSRADLIAEYHRATRYDVSDIAWYQAFALWKLACIAEGVYARYRAGVMGVDGVDVEAQGTRVERLAEAAAAALTTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0F4</accession>
    <name>A0A011A0F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="27806" checksum="0541E4DB147EB0D6" modified="2014-06-11" version="1">MRRDGHSFYSVDVRKTPRLNAILERVNDTRSVDVSDLAGALGVSEATIRRDLQSLSRSGLLVRTHGGAVANDRDGELPTQIKAVRRHTEKGRIGLAAAASIPDGAVIGMTGGTTMLELARALADRRNIAIVTNAVNIGAELIGRPGVHLVVIGGVARPSAELVGPAAEAMLANYHLDMAFIGVDGLTAEHGCTTYDEMEAQTDRAFLQRASRAVVLADHSKLGVVRFAQITPLASIDQVVTDRDADPAQLATLRAAGVHVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAN2</accession>
    <name>A0A011AAN2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053144_0_0_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="262" mass="28771" checksum="138A1C5B782C4C94" modified="2014-06-11" version="1">MASRTENDQAGEYRINDLARESAIPVRNIRLYQERRILPPPVRRGRVGWYSEAHLARLRLIARLLDRGYSLAHIGELISAWERGRDLADVLGLEAALTSPWSEEPQTVISAGDLQRMFGKQEERGTLDRAISSGMLRPEGTRFRVASPQLLDIAVQLVQAGYPLSVVLKLAEDSMHDIERVAERYVSLVKATITPSLSPGDSHGTDEPAEIDDPAAAAALVQSLRPLARKSVDAMLAMAMENAVNQVLGDAVSALAKETRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAN6</accession>
    <name>A0A011AAN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="28274" checksum="3E2FEAC136F399BD" modified="2014-06-11" version="1">MVPEQRRQQIVTALGTRGMVRADDLASQLGVSLETIRRDLNELERRGELTRVYGGATRAPKQSESWDRRSTSHVAAKRAIARYAVRLLQPNRNVFFDVGTTVYEAAKALPGDWVGTILTTNGHVAQSLSDHPGVRVQLAPGNVRDEELSVSGPEAERMFEKGYVDVAFVGADGIHPQAGLTGCHEGEAVVRRLVIARSFEKYVLADSSKLGRVSEFRVSELASITAVITDSDVTKDVLDALVARGLRVHVAPPVAVDQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAZ8</accession>
    <name>A0A011AAZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase</fullName>
            <ecNumber evidence="2">4.1.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.206"/>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="209" mass="21888" checksum="B58E56D331EC2C97" modified="2014-06-11" version="1">MTERGAIAEVCQRMVADRLVVGTAGNVSSRDGEIVAVTPTGVPYASLCPEDVGLHALDGTPVDARLKPTSELPLHLAIYAARPDVGAVVHTHSTAATALSCLVTQIPAVHYYVGLFGGSPRVAPYVEYGTDALAAGAVNALEDRTACLLGNHGAVAVGKSLSEAYERALYLEWVCEVALRVLSSGMIPRLLDGVEMDDATARLATYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC56</accession>
    <name>A0A011AC56_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglycosylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725653.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.648"/>
    <dbReference type="HOGENOM" id="CLU_045108_0_0_11"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="291" mass="31775" checksum="B1B0E98C2594A52C" modified="2014-06-11" version="1">MSKESSHPTQLSAESSPRAGGRHRAPRRLSPLGRGLAIAVVTGLAGITPLVIGATPANADVNWDAIAQCESGGRWNINTGNGYHGGLQFSPSTWRAYGGRQYAGSAHQASRSEQITVARKVLRGQGIGAWPTCGRKGYHKSRGWSDQASRSYKRQKASGEHTGYKSERSKSTRWSTKKSWKNRPTENRSHRTWTKKHRYTALAVPKKGAAHTVAVRPAEVLDFVPQRQFTRDQRPVVAAPRVLSYLVQSGDSLASIAAAHQADWQAIYEKNQDAIGANPDVIHPGMRILIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACD3</accession>
    <name>A0A011ACD3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="265"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="431" mass="43987" checksum="439614686224664E" modified="2014-06-11" version="1">MTVVVGLHLGSDSARALALGPDGEVVARAYAPYPGAVGWPAGHADPAGWLAGVTAALESVLAELPSDRPCAAISLGGQSPTTVPANGGLAVTYRHPAGATGTPAEQHAAQLSVLSDESGGGIEPLQVYDWLSARLGAERVQSRWPGDPELPGYGPVVTTGVAIGRTDGSHGLPAGIPLVAGAQDAYLAFWAGALDRPGRGMDPGGRTGGMAVVVPEDVRLPGMYALTSALSGLDILGGPVSGHGLMLEWLRTITGCGIPELIDLAATVPAGADGVLVLPYLEGARAPRWNRQLRAEIVGLGSDAGRPQLARAVLEATAYGLAHVAEGLAAGGFTLTTLVTAGNPARSPLWNLIKASVLEVPVEVPEETDLAAYGSALSAGAGVGWWPGPGQCATHAWPRPTVTVVDPEPQQAYHEGYQRFLELGSASESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACU6</accession>
    <name>A0A011ACU6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707363_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="390" mass="42977" checksum="91770661F6E1AF1C" modified="2014-06-11" version="1">MVSRLYDSLRASALQVYLDAHEQASQSSEDFPDRVDRELRDCSGAILVVSPDVVGSAWVKHETSVLANRRKGMVTGQLPLIVLYVDGAKPDDLRGEHWNITRIPWLGSCTELSEAHDFAMTRLQPLMSRASRDLRKESIYLTLDSTLRSLQLEELTAALAVLGLKAHVWSPTDAAESLATALLDLRDVLKLDAVTSHLSGLHPSVAHQVFELVVPFTWLEEAQGASFRLGITSPAKMIEVNGYYAAMTCEMLGRRAFPAHPARWTVLEAVVQHGDDWSLDYANACRVPLRRHFDVSETDPRADRTVNTVLGQRPCIIVFSGRPPADKSAIDAVRLAFPNLALAFVNTPSPAYPGAVAKWWVTLDPPIDLEKESVVVAIRKLAASAKRGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGF5</accession>
    <name>A0A011AGF5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent enzyme, glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570015.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2164"/>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_11"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="445" mass="47805" checksum="A302F33EB7ACC6F7" modified="2014-06-11" version="1">MKELLDATTTLAADYLARVGTRPVARPTTLDALADTIGAELPDDGVDPRTVVEDLARGVEEGLVVTNGGRFFGFVEGGVLPAALAADWLTSTWDQNPGFYALSPAAAAVEEICRRWLCDLFHLSETWSAGFTTGAQLANFAGLAAARHHVLTNAGWDLERDGLFGAPPITVVVGRERHATIDRALRFLGIGQAQLAIVDVDDQGRLRPDRLPTIDGPAIVCTQAGNVNTGAIDPVGAIVDRANGAWVHVDGAFGLWAAASPALRHLTDGVERADSIATDGHKWLNVPYDSGIVLCARPEAHRAALRLSADYLVRHGERQGSDWTPESSRRARAFAVYAALRSLGRRGVAELIERSCAQARRIAERLDGDFAVLNDVTLNQVLVRVGDDDERTRRVAAEIQRGGDTWLGTTVWQGRTAIRISVSDHAIDEAAIDTLIRALRTAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH42</accession>
    <name>A0A011AH42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2395"/>
    <dbReference type="HOGENOM" id="CLU_044063_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="271" mass="27390" checksum="B79421F28421E2AD" modified="2014-06-11" version="1">MRRAAVLGSPIAHSLSPVLHAAAYEALGLTAWSYTRVECAEEGLAGFVGALGPEWAGLSLTMPLKRAALGVATEVSPEAAAIGAANTLLLAPGRRRAENTDAPGMADALREAGLRSASAPLLLGAGGTAQAALAALAGPVPLAAAPVTALVRSPHRAAELRTTAERLGITLDVRPLDEAPSRVATADLVISTLPKGAADPLAHAALRPAAVVFDVVYDPWPTALAAAAAAAGCRVVSGLDLLLHQAGHQVRLMTGRPAPIEAMRAALALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AH78</accession>
    <name>A0A011AH78_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808258_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="37623" checksum="866D62AE4DEFA97D" modified="2014-06-11" version="1">MAPASVRAPVDRRRKVLDRDRALRVPDTARARTTQGRAPRASRPKATLLTASHPTASRPMVRRPTARDLTTRPPRRRHSMGPARRATQRRGTRRTARGPVGHKDTQLVNSRAPRGPGRSRKAARSRRARSHRVLVRYRRVPARSRRAARSRRVGRSRKVPGRGREDLRLRDPTDLRDLKDPRDLKDGRSPVSAARAVGVPGARSHRTPPRPAPAYRAVAVTPPRAAPPPVRCPARPHVPCPDRPTTPSPAPPHTRCRARSVAPHPARVNPPCPAPADAPSPAPWAARSPARSAARSPAPPHTPCRARSATPYPGPSDARSPGRSARTDWSTAQAPRPGRYSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIA0</accession>
    <name>A0A011AIA0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoheptose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570164.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2797"/>
    <dbReference type="HOGENOM" id="CLU_080999_0_1_11"/>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="21567" checksum="C4BEFF72C6C7BB0A" modified="2014-06-11" version="1">MTSQLDRPLFTGLDRAAAHCVALEETLVRLRTTQLPLLNAWGATLADRLSTGARLLAAGNGGSAAQAQHLTAELVGRYQDERPAYSAIALHAETSSLTAIGNDYGFEELFARQVAAHGRPGDVLVTMSTSGSSRNLLRATEVARECGVTVWAMTGPRPNPLAAAADAALCVEADRTATVQEAHLVALHLLCAAFDAALADHRMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIH7</accession>
    <name>A0A011AIH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851244.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768869_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="360" mass="38331" checksum="DECD47DA03851551" modified="2014-06-11" version="1">MNELRTRDLLIRMANDPAPPTTVDVDRAIATAQLRRRRTQWLVIAAAAAVVLVVTLGVVTAFKPEDHAQPAPFVSAPSTFDPLNPRLEVGWVPDGFTSGLWNAAVTAEFRTYSGPKAAGVTVYAIPRTGGFPAVELFGRPIDGPDINGRPSTWHQVPVPIYTDPQVVASPGSSPSPTNTKAPTRALKNAGILRWEYGKGGTAQVEVANVTDPMEVATRIARSVRLDRPKPFSMPLRFSDPKIPIVRTAGGTGGVTMEFASAGWKRPSALIGVGEARKAANLPKPNVTLGTRKIREDLYPGLSAIIFDLAPGTEVSLQCGGPDDTEASTVATKAECRRLAASVQPVGTLSDPTTWTTSVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ27</accession>
    <name>A0A011AJ27_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721043_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="383" mass="41434" checksum="ACA09F2BACA04EBB" modified="2014-06-11" version="1">MISSSFLARLARRPGILLRAERLVCSRGPDSVQWQVTTSPELTLSRLDGPPIKVVILQHPEYGPCPPGVVTFHVGSEDSDSVWPPYSKRAQQQAAEAYAAYGGDPAELVTTVFADPLTLVSEFLRDPDLTRWRRRARALVAGAATVPLATAGTRGTAADSVRGALADRWSAESYPHGPGGDRRPLRGVVHVFRTVDASGVALVLIVDDAEPEEWTAIAVLGREAGRAARNAWLHWSDLLQFLTTPGRAEGVSLNAEDLDPFEVERLAVLGGGQKRTSAWDREITPYLDESDTALVRLAGFLARHGAQTPVFGYELGESGWPADFAWPAEDIRIAVLPEPDGDDDEETRRGGEAYVAAGWRAQTASEWCEQIDALLAAVPRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJ81</accession>
    <name>A0A011AJ81_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851652.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3181"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_3_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="346" mass="35077" checksum="F06A999FBD4C7E5C" modified="2014-06-11" version="1">MSGQLSERTAVPPGSSRQFWADLRWRGAPVGVPWLVALLMLVVSVILYPSSIGFGGLATMTPLLGVLIIASLGQSLVIGTGGIDLSVSSVVTVVGVIFVLEAGTPGGSIPLALVYSLAAGLVCGVVNGVLVEYLALSPLVSTLATGQIMAGLANIWYGGGANRLAVPPDWRSFTGSTFGRGISYLLLAATVLVVLAGVVLSYTAVGRRLTAASTSPKAGRYQGIAVRRYRAATYVLASLLYSVAGVFLVGSIGTPTLSLGDVYQLSTIVVVVLGGAALSGGRLHPGATMAGALFLSLINQDVAATGAAAGTQGVIQGAVLVLAMLATSIGALRMLLRRRRGSTAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL92</accession>
    <name>A0A011AL92_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 1, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852642.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3880"/>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="32468" checksum="4F2B987494607627" modified="2014-06-11" version="1">MAQPVTGRRARARRPRRSWVGWLFAAPAVLVYATFVLRPLLLTVQYSFYEWNGIGASTWVGLDNYRRLVTDPELFATILHALELILFFSLIPVLLGLFVAAAIRGIATSRLATVARTVLFLPQVIPLVAAGIMWSWLLSSTGLVNALLSGVGLDRVTRAWLGDFDTALPAVGIIGAWVLVGLCTLLLLAGMSKIDPALYEAARLDGAGPIREFVSITLPSLRQEIGVCVTVTVIAALASFDIIFVSTQGGPGGATSVPGLEIYYLAFSEREIGMASALAVTLVVLVLACVLPIQRFTRDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALQ9</accession>
    <name>A0A011ALQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="19941" checksum="F079D1C7B4C552A9" modified="2014-06-11" version="1">MTRDDVVFGEIQAPVDAVLERDGERWTLVLRRRFRHDEKRLWEMLVDPAHLRRWSPVVPERPLTSPGPATCRENPGDEPNDAEVLVVEPPHTLVHRWGDDLLRWTITPAEGGAVLELRQTFDDRAAAASYAAGWQVCLGRLAAEDDSPRERVTGPRALDYGWPDLRERYDAAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AM24</accession>
    <name>A0A011AM24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4196"/>
    <dbReference type="HOGENOM" id="CLU_061751_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK" evidence="1">
        <location>
            <begin position="134"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="40477" checksum="F7E5EAE73703A9D6" modified="2014-06-11" version="1">MSSVSPALSGAVTIAREMVRCGVSRAVTGRLPDRAERVTAPWLASVLGREVRSVSLLSQDSGTAARARIALDAEPGRVFVKLTPRDVRQQLLMNVVGLGHREVLFYRAVAADVPIRVPRCYAAFDDPALGRIALVLEDLTGKATFRDVRDDVSVAEAGAVVDAFADLHAALWESPRLTGPLAALGPLRRSPVVGVFGRALVRRALARPAAPVADLVPAALARRSRVVTENLEAIDDFWAAQPRTLTHGDPHLGNLFFEGASPGFLDWQVATICPGIRDVAYFLVTSLTPANAREHERRLVDRYGERLAAAGITSDPDTLWTSYRAIAAEAYIAALATAGAGERMQPRAVARSGVARASAAVQALDTFDAIADLVGLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG15</accession>
    <name>A0A010YG15_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847649.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2329011_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="98" mass="9959" checksum="FA3802DBC2941E2B" modified="2014-06-11" version="1">MAADLPAAPVFALHCPVCQWTRTDPAVEQAALDIAGAHDDAHHHGHPTTVLVLLLTDPAVLDAAAGGHQRAAALIGRTITAAATAPLSPVARPGRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGD6</accession>
    <name>A0A010YGD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569589.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968802_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="28910" checksum="CC8094DCCFBD7369" modified="2014-06-11" version="1">MTAVVAALALLGAAALLAVPGSVRGRLRVVARPAGPSPRTRLLGAGRRPVVPTRWRAHLTVPLLVLTAVPTAAAVGPVIAGAALAYGLAGRRALRQRAAAKADDALRALGAVALAGLADDLRAGRTPSAALHAAIVTVEDGPVTAPAATALATARIAVVRHPFGDVPALLRAVPGPLEPAFRRLAAAWTLADCGIPLADVVGQLDVELRRLRRLSERAAVHTASARTTARLVAGLPVLGLGIGQLLGASPVAVLTRTPGGAACAGAAVALHLIGFALARRLSRVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGD9</accession>
    <name>A0A010YGD9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847855.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.312"/>
    <dbReference type="HOGENOM" id="CLU_046126_0_0_11"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="223"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="462" mass="48510" checksum="86BE4EBFA76B93F5" modified="2014-06-11" version="1">MTTSAQDLVERALALSKSDGCIVIAGESTSANLRWATNTLTTNGVMRSRSITVIATVGTGTGVASGAVSRTTVATDELESLVRAAEETARGNGAADDAQPLVPGGAAADWDLPPTETSIDVFSSVAPALGDAFGAARGADRLLYGFVEHEVDTYYLGTSTGLRLRHAQPQGHIGITGKVGSDLSRSAWVGQATRDFSDVSIASLDAELAQRLAWSARRIDLEPGRYDTVLPPTAVADLMIYAYWNMSARSAHEGRTVFSRPGGGTRVGERLTPHPVTLRSDPGAAGLSSAPFVLAQASSGTSSVFDNGLPLEPTDWIRDGSLAALLQTRRSAEITGLPVTPVIGNLVMEVGGASGGLDDLVAGVDRGLLLTCLWYIREVDPQTLLLTGLTRDGVYLVEGGEVVGAVNNFRFNESPVDLLSRFAGASVTSPAFSREWGDYFHRTAMPALRVPDFNMSSVSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGL0</accession>
    <name>A0A010YGL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_0425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847992.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.409"/>
    <dbReference type="HOGENOM" id="CLU_039622_0_0_11"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="113"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG79390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="29150" checksum="C1937F36390F7EA3" modified="2014-06-11" version="1">MNLDPAWVADLVARALAEDLGGPDGVDVTSVATIPAGQIDVVDMVARAPGVVAGLPVALAVFDAVGDVTAEALVADGTAVRRGDVLATITGPTRALLTAERTALNLISRASGVATHTRRWVSAIEGTGAKVLDTRKTTPGLRPLEKYAVRAGGGTNKRMGLYDVAMIKDNHKLAAGSITAAYDAVRGTFPEVPVQVEVTTVAEAVEAVAVGATFLLLDNMGPALLREVVAAVGGKAELEATGNLTLDRAREFAETGVDYLSVGGLTHSSPILDIALDLRPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH32</accession>
    <name>A0A010YH32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoglucanase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569668.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.613"/>
    <dbReference type="HOGENOM" id="CLU_564655_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="SSF49590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPBB_1" evidence="2">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="483" mass="48777" checksum="A13C47044E915715" modified="2014-06-11" version="1">MTGPRWEDEPIDAWDPADTDFFGAPRSKGGNTGEFRVVDGASADSGRGKHRGSRRRGLGSSAVAGVAGAVAARSAVDRQADQPELDRPVSAGPGFERAGSDRPRGFGSVAGEPRSFRSEPVASSFETADFRAGATAMTEVVPAAKDGGRFAGLRRALRRRWFAPSVTGGVVLCSVAFVTGVTQFAGAACAAVPPAGVERSGEATFFDGGVGNCSFPSLPADDLYVALGPSEYSGAGACGSYLDVKGPSGSVRVKVVDQCPECEEGHIDLSREAFEQIADPEAGVVPITYSAVANPAVGKLSARVKEGSSEFFLSILIDNHGNPLTNVEVDGTDLSRTTDNHWVADGGLGTGPFSVKVTDNAGRTATIPNVTLSPGSVQQSTVALGGGNAVSAPTTKAAAPASSSPASSPAADAPLAAAPRDATGESSAEDSSSSNEQNDTETAVTPDADASEEIAANPAPSSSVAVPRATESAAGSTGRNSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHN6</accession>
    <name>A0A010YHN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569715.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1936844_0_0_11"/>
    <dbReference type="OrthoDB" id="2083554at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458846" evidence="2">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="124" mass="12988" checksum="111B3A665B31DDBC" modified="2014-06-11" version="1">MRRLFIVLTGTFTLLAVAAPASAFAHDRVTNPYLHSALDVLTLAVVTAPLWTAYLWGRRNRGALFALIAGLQLPVAVVAFVPIADPVLHTIALTSGLALTAASIAAVRHATRIQPAPVGVGSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHQ5</accession>
    <name>A0A010YHQ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848570.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_10_0_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="248"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="43447" checksum="F761A19AA1C2F253" modified="2014-06-11" version="1">MTDPQHPDTATDRPDPAEHARWVAVADRVAAQLSSDVVARDRSGAAPHKEVELLRDAGLLPLLIPARNGGHGGSWLTAFEVVTRVGRADTSIGHVLGYHYLHNWRTRLARRLDVVERLATETAANNWLWGGAGNPRDAGLELEPTSGGYLVRGKKFFATGAEVSDRVIASGTDTVTGQKYGFALPTRTAGVVHGEDWDSLGQRASASGSIAFDGAFLAEEDILGPGEQTDPDAPAYPSLSALGFQILLGLLAVATAEGALRFAAEYTRTKSRAWATSGVAEAADDPLVRVRYGELESQVRAARALTDRAGAAWMAAASRGWELTHAERGEVSVELSAVKVVTTRAALDATQGVFELTGARATKTGTGLDRYWRDVRTLTLHDPVSHKAIEVGDHLLRGAYPEPSGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YIH4</accession>
    <name>A0A010YIH4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1101"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="281"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="525" mass="55293" checksum="DD69F4A287C72DE3" modified="2014-06-11" version="1">MSFRHRISTRLIVGFAAPLLILVIVGAISYRNTNELVYTGGRVTHTYQVLEGLDNIMDAVKDGETGQRGYLITGQDAYLAPYTEASNSVGGRIDNVATLTADNPVQQKRITTLRTLVEAKFAELKETIDLRRSSGFAAAQRVVLENKGKAVMDQIRSVLDAMSSEEAALLSVRAETTTDTANLSRTSIIVSIVVALALVVTLALLISRSILRPLSALTARMADIADGDGDLTSRVDENRRDEFGPLGSAFNRFAEKIARSVRDIDHEATRMAAAAGSVAEAASRISGTAARTSQQANAVTDSAREMSVSLETVAAGSEEMGASIGEISANASDAARVVSEAVSVANSASETVNELGTSSAEINNVIQLITAIAEQTNLLALNATIEAARAGESGKGFAVVASEVKDLAQETAKATEDISRRVESIQGNATAATAAINRMSEIVVRVNDYQTTIAAAVEEQTATTSEMSRGVTMASGSTREITDNLSGVAAAAVETTQALDGALHSINELNEMSAGLKRIVGQFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJ39</accession>
    <name>A0A010YJ39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432374_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="189" mass="19765" checksum="DBC59FD4353FA907" modified="2014-06-11" version="1">MEEVPGKSAPGKSASGKSAPGRSAPVGGADGVPGGALVPGDFGEVMGYWPVREHGNWVTPEGACSAPTGATRYDFSGACKAHDLGYDLLRYAARIGEPLGPWAREAVDAAFGRAMEARCRAVGGSGSCRAAAAVYHGVVVANSWRQDWREPRPEPWVPWVFVALALTLAPVAVNAVSAHLDRVSQRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJN5</accession>
    <name>A0A010YJN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type metal ion transport system, periplasmic component/surface adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849338.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1498"/>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_11"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458111" evidence="4">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="32895" checksum="6F3C5E9FCBD503FC" modified="2014-06-11" version="1">MYSGPLRAALTALLAVGVATAATGCSSSDSDAAAANGKLDVVAAFYPLQYVTQQVGGDRVSVTNLVEPGTEPHDLELSPKQVAEVTDADAVVYLRDFQPAVDDAVDGGAKDKSLDVATVEPLKDGYVPLEEGELHEDEKGKDPHVWLDPTRLAGIADAVAKKLGDLDPDHASEFTANAKALDTKLSTLDEEYRTGLASCQEKTIVVSHNAFGYLAARYGLTQVAITGLTPEEEPSAARLAEVANYAKQNGVKEIFFETLVSPKIAEALAAEVGAKAEVLDPIEGIEKNSGDDYFSVMRTNLTTLRGALQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YK84</accession>
    <name>A0A010YK84_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849625.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1699"/>
    <dbReference type="HOGENOM" id="CLU_061391_0_0_11"/>
    <dbReference type="OrthoDB" id="1789233at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="263" mass="27377" checksum="09FC97B23E0EF5A4" modified="2014-06-11" version="1">MTHPTPTILTRYAHGGNGLDDATLWSVEVHLDGCADCRAHLATPATADLLDRVAASLDQAIRTGPAPAPYRRPAFTVHRRWLAWTLLPWLAMTIAVVTCAVALDRVAPSLPSLVLLLAPVAPLPGVAASWSRRFDPVWELIVTTPSAGLAMVLRRTLAVLVVVLPVLLVAGLSTGTSLALTLLPCLAFTAGTLALGAFVGVRPAAIGLGLAWSGAVLLPSLASESLSPLLRPGSTALWAVAAVAFAALVPLVATHFRRLRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKP9</accession>
    <name>A0A010YKP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849855.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1837"/>
    <dbReference type="HOGENOM" id="CLU_097884_0_1_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="186" mass="20581" checksum="20F2185658C9F1B2" modified="2014-06-11" version="1">MAVAERTRKAVVPSGVERTMAEDELIVSKTDARGIMTYVNDVFLRVSAYPESEVLGQPHNMIRHPDMPRCVFKLLWDTIKSGQEIFAYVVNLAGDGAHYWVLAHVTPSFGPGGQIIGYHSNRRTPDRAGMDVIRPLYGQLAAEERRHAKSSDALAASAAMLARKAEEHGGYERFVWSLESARAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL59</accession>
    <name>A0A010YL59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850109.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2030"/>
    <dbReference type="HOGENOM" id="CLU_013687_2_4_11"/>
    <dbReference type="OrthoDB" id="704242at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="6">
        <location>
            <begin position="188"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="399" mass="40746" checksum="2B3BC79408A59EE1" modified="2014-06-11" version="1">MLRSLFSGISGLRAHQQMMDVTGNNIANVNTAGFKSSQAVFQDTLNQMLKAPASPQGAVQGGTNPAQVGLGVQLAGISTNFTQGSAQTTGRSTDLMISGDGFFTVKTGAETLYTRAGSFSFDANGGLVTNDGARVQGWVADADGVIASNTTPTDMSLPINTLLAPSQSTEVTFSGNLPSDAKEGTVITPSLTVYDGSGNASELTLTLTKGASTDTWAVKVSDGTTDFDGGDITFSATGTTPDPATLTFPGAAGDIAVDIAGLTNYAGTTTVAPQKQDGYAMGSLQGFSITKDGQLVGSFTNGLRKPLGQIALASFNNAAGLEKAGGSMFRTTVNSGVPQMGTPGGGSRGAIMGGTLEMSNVDLASEFTNLIIAQRGFQANSKIISTSDELLNDLINLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLN8</accession>
    <name>A0A010YLN8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850325.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2205"/>
    <dbReference type="HOGENOM" id="CLU_105089_0_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="21204" checksum="6CC5D6B15284EE12" modified="2014-06-11" version="1">MGRHKQPAIRDRILDACVDHALAHGLPNRLEPLATAAGTSKRMLIYHFGTRDELLRETLVRARARQRTYFGELMTPQPDEPYLCTLRRAWRAMTGPDGRPYLSLFGRLREDTEQRLWPGFRRESTTDWRQPFEDGLAALGRPDLGTLVLAVIRGLIMDLESTGETARADQAFDDFLTLLGADEKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMH7</accession>
    <name>A0A010YMH7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein YfhO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2505"/>
    <dbReference type="HOGENOM" id="CLU_310306_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="965" mass="103535" checksum="9645D6AB99727738" modified="2014-06-11" version="1">MSATQQLTPRASESPAEEKSPRWWRRRPDPLVTIVVLAIAAFALGGIGSPLWGGSSLTETGLLARVAPYTDGELLGVQRETLDLGDTVDSAIPNAALFGDAIRSGEWANWNPYALGGGSLGGTPNAGMASPVALPFWFLPAWLASAYMLLLQIVVAVGGSYLFLRRLKLGKPAALLGGLAFATSAFMIVWVNWPQSRVAAFVPAVFWALECVVQNRRPRDAALLALTCAAMWLGGFPAVTMYALVTGAFYVIVRSAAEHGWTRRTLGVWLRALAGVGTGVALVAIQILPWVSMMSTVLVRGREQTPDQHIPTQVLLTSIAPYVFGTVQPPEGPYWYETRIFLEEVAYVGAGVAVLLIAAIALFRRARVALPRGAWWFFVVSTAVWGGIIFLGGPPLALLQKLPYLFSDNAVERARSVLGFGVAVIAAVGFQLLLDRARDHRPLSDKRRAVWGGAVWAGVAAFGVVLYVSARRFALVHDAEWGFPGGGPHLGWLNRELAIGLMFVCAALGAAGWLWFAPRHRALRLAAAALIPLLVAAQALLWVHNYWPRTPVKNFYPVTDTHRYLEANLGHERFWGSNGAVLGGVHQLHRLRGLQGHSFVEARFAELLEALPGYQFSPPPKPATFLWPQPLNDGTSPTNPILDRLSVAEYVTPATQIPYGVEKKDAGDASTYTLSPGRPVSVPVPVTGPIRGIGVTPVSRDVTETYARWIGVVLRDSSGREVARSERVDRAIAADQPFYVPLAAEDVPAGTRLTAEISLRGDAPLLVAGRSGAPALSTVARTNDGLTLVKDGDAIVYQRATALPRARWASSVVVERSSERRLGLLADGALAADAVVLDAPGGAAEGKPATVRWVDDGFDEMRLAVDAEGAGYLVLADAIQSTWRVTVDGRPADLVRADHGLAAVHVPAGTHTIDFSYAPKYAGLGAWLSAGTAILLVAAVTGEWWYLRRRRADRAEGGVPAKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMS8</accession>
    <name>A0A010YMS8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862112.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2605"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_11"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="466" mass="46927" checksum="7B7EF329159DD12C" modified="2014-06-11" version="1">MLRAPADAPATPRFIVPVLASGGLVAAIMQTIVVPLIPSLPTLLDAAPDDASWVLTATLLAGAVATPVAGRMGDMFGKRRMMIVSLGLLVVGAVCSALSGSLALMVVGRVLQGAGAGAIPLGISLMKDILPADRQGSAIAFMSSTMGTGAAIGLPASALVAENADWHLLFWGAGAVGALALVAVVAVVPESGLRAGGRFDVVGAAGLAVWLTGLLLVISKGNTWGWTSPAVVGPAAVAAVVAPLWAMFELRRKAPLVDLRTTVRRPVLVTNCASVLIGFAMYGSVMILPQLLQAPRGTGFGLGQSMLAAGLCMAPSGLVMLFASPLSARLTAARGARTTLLVGATVLGSAFAAASFLMHAVWQIVLIAIVTGLGIALAYAAMPTLIMQNVPVGETAAANGLNTLMRSLGTSMSSAIMAVLLADAFVTTGGGALPTGLGAFRLAYTVAAAAALTGALLCLLLPRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMU7</accession>
    <name>A0A010YMU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2620"/>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="267"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="463" mass="49842" checksum="EE04649331E1E9C1" modified="2014-06-11" version="1">MSTSEMSKPDGQTDGYREVKDVNGRVYRVGETDQQILGRSRRWMVILPWFAMMAISSSEYAFTSAEETLSSAHNWHGSHIFWLLGVWVFFQAAVAFPVGKLRESGRLPVKAAMMLGAIGTVLGYVALAYAPNVFWAYLGFGFFGGTGAGIVYATCVNIVGKWYPERKGGKTGFVNGGFAYGSVPFIFLFKSYMDTSNYSGLLLVVGLFLAFAVAASGFFMADPPKNWWPPHVDPLRASADDPRIRRSLEMNPPAVKQYTPMEAVRTGILPLMWFCLLCTAGINIFGIAFQVPFGDEMGFAGGIVALAMSLKAIVNGTGRGVIGWISDRYGRRRTLIFVCFVLGLSQYAVYFSGSIGSLPLFLLASMVSGFGGGAIFPLFAAMTADYFGENNNASNYGLVYSSKLVSGLVGSGLGAVVVATWGYGGAFILAGSIGLGAGCLAFFLKQPGRNLRDLRQESVALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP20</accession>
    <name>A0A010YP20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851413.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3009"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="31108" checksum="672BAA75C9C49777" modified="2014-06-11" version="1">MTIAVRDLTCRYGAVEALSGLTFSLPAGTIYGLLGRNGSGKTTLLSTLAGFRRPSAGSVRLDGEPVFENPRAARQLCLIAESGDVGDKTDTLRDILDLAGRLRPGWDAGYAAKLADLFELPLTSKLGTLSRGKRSAFAVTVGLASRAAVTMFDEAHLGMDAPTRQAFADELLRDYLERPRTIIISTHLIEEQSPLFERVLVLHEGRLLLEEDLDELRARGVSVTGPLSLVDDFAAGLTVLGEQTLGPTKSAMIYGEFDDERRRAARAAGLELGPVAVQDLFIHLTGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP49</accession>
    <name>A0A010YP49_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3045"/>
    <dbReference type="HOGENOM" id="CLU_1174429_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="25690" checksum="8F6C3F16E9A307B5" modified="2014-06-11" version="1">MMRTVDCRIDQRVLVNVRVDPDAAARLLPAPFRPRLVGGAAVAGICLLWLEAVRPAGLPARAGLRSANAAHRIAVEWDEGPEPGHGVFIPRSRHTDSAVTALAGGRLFPGVHEQARIRRTAAPDRVDVHLPGPIEVTLTGPVADRLPPGSLFADVDAATAFFARDSTGWSAGRHPGTLDGVELLAERFELVPLDVTSMSSTFFADPERFPVGSAHFDSALLMRPTPARWRALTPWRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPB8</accession>
    <name>A0A010YPB8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962134_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="289" mass="29473" checksum="A447D83162EE3A8A" modified="2014-06-11" version="1">MTVAERPGPRSGYAAARGLLADSFAQQLGLGEGACCEGVHTGAGFGSVTGDGGFVSVGPGSALRSVFEGTGLILGPGRASVGSRGVVRAEAEVVALGAREFVKTGLDLPALGLPLGFVSPDRGVGDRFWLGSLGVLFALVDCPGDSDGGGNESPPISGAGVASGVPTDTSPLPHPLIMTANRAAIPHITQRLMPPRLSSPPGPTTARAPQWHAILPTPAAPATALFGCRSRAERSESPHDPVAAVRVQYGRTGEFRVVSGAAANYNKAFGSRARRHERMLLSGERGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQK9</accession>
    <name>A0A010YQK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852310.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127487_1_2_11"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15204" checksum="9E84269EAAC9D45D" modified="2014-06-11" version="1">MAADFQTHVHDHAGAGVLETEQCLALVRGERLGRVGFVRAGTVEVLPVNYVLLGTTIAFKSGYGSKLGAALDGAPITFEVDGVGYTGALPLGWSVVVKGTAGFLADDERTALLLAGAPLPSLPSAAATGRWIVIRAEEITGRTVPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR19</accession>
    <name>A0A010YR19_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852567.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3804"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26035" checksum="4F714DA158C79C3A" modified="2014-06-11" version="1">MSGLFDLSGRLAVVTGARRGIGRAMAEALAGAGADIIGVSTQAGPDDDVATTIRGLGRSFEARAVDFADREAVVALGTELAARAPDILINNAGTIERAPAIEHPLEWWDRVLEVDLSSQFVLTQLVAAPMLERGRGKVVFTASLLSFQGGINVPGYAAAKSGVAGLTRALANEWAARGVNVNAIAPGYIATDNTAALRNDPDRSRSILERIPAGRWGRGDDLAGATVFLASAASDYVSGTVLPVDGGWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YR98</accession>
    <name>A0A010YR98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852647.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3884"/>
    <dbReference type="HOGENOM" id="CLU_079903_0_0_11"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="238" mass="26379" checksum="FA260ABCBD7FAEF2" modified="2014-06-11" version="1">MTWSTRQLADLAGTTVKAVRYYHEVGLLEEPERAANGYKQYGVRHLVRVLRIKRLVDLGLPLAQIADLGEADDRPESALRVLDAELAATIERLQRVRAELAVILGERAPFDLPEGFGTIGGNLPDADRALILIYSRVFDPAGMVALREMVRTSDLEPEARALESLPPDADESLRQEVAEAYAARTEQMLAEHPAVAGLRAKAPRGFSFADEVINRALHELYNPAQLDVLHRVNRILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWC3</accession>
    <name>A0A010YWC3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent enzyme, glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569626.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.468"/>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_11"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="482" mass="49323" checksum="BD167F26351B4952" modified="2014-06-11" version="1">MASNASDHGGSRDTALAGNVEALAALLAPVLEALAEGARDRGGPAPAGHPADLDASWRGAFTDFGAPGIGAGAALGELVRMFAAGSVDPADPRCAAHLHCPPLAVAVAADAAASALNPSLDSWDQAPVGTSLEPAVVAELADLVGYPSTADGVVTTGGSESNLLGLLLAREHAIPGAVRSGVPAGRYRIFGSEATHFSVHRAAGLLGFGEDAVAPVKTGRDHRLDPDALDEALSRADHTPIAVVATAGTTDLGAIDPLPEIAEVARKHRVWLHIDAAYGGGALFSPTLATKLAGLRAADSVGLDLHKLGWQPVAAGVFLTSRATNLAALARRAEYLNPADDEDAGYTSLLGRSLRTTRRPDALKIAVTLRALGRDGLGALVDRCAALAAHAAASIGRQPALELYQPPNLTTVVFRFTASNEVNARLRRALLAAGTAVIGRTEIDGRVWLKLTLLNPDATHADVDALLAAVVSAGTQELEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWE2</accession>
    <name>A0A010YWE2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725647.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143972_0_0_11"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="128" mass="14107" checksum="63D12E7680A3F1BA" modified="2014-06-11" version="1">MSNAVVERLIGALNSQDLDAIASCFGPDFRGEWPAHPGRDVHGPEQVRRNWEMIFTTSPDITIAMTNAVEVGDEVWGEWHYTRAAGQDLRGVIIITVGDDLVQRSRFYMEPVDAPSASTPGGPRLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYK3</accession>
    <name>A0A010YYK3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849103.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_1_11"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="65" mass="7092" checksum="ACE2EF199411A361" modified="2014-06-11" version="1">MSDPRFFKSSYSGGSGGNCVECAYGSDSVFVRDSKDTDGTVLSFGRPAWATFIDDARRGLFDQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ17</accession>
    <name>A0A010YZ17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingosine/diacylglycerol kinase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849368.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_0_1_11"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="31967" checksum="952A428B817BEA5C" modified="2014-06-11" version="1">MPQELLVIVNEGAGSTELAAVDKAVEVLRRVADVVVARTADLDALGAALRIHRERTTVLAGGDGSLHAAVQLLYDAHQLDPQRPFGLIPLGTGNDLARTLGIPLDPVAAAETVLDGYARALDIAVDNTGEVLVNAAHAGVGAEAGRLASGWKPTLGVAAYPLGGLVAGFTSEGWHMAIEVDGEQVHGPETPVLMLGIGNGRSIGGGTPLAPNAEPDDGLLDVVVAAVQGPRNRYEYGLALRNGVHIRREDVQVYRGGTVVLKVPDGADVFRVNTDGEISDEVTHRSWDVKRGVYSILVSGSARAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZW7</accession>
    <name>A0A010YZW7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849785.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_4_11"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13261" checksum="444958A9AD168070" modified="2014-06-11" version="1">MDNRTSRNGWHAPEARVRCAVAPGLVTITLNGEIDLLVIESLDQALATVGEAQPADAVVDLGGVTFIGSQALSFLVRLHHLTAEQGRLTTLHNVPPMVRKAMVTVGLDLLFALEEGGISGQRPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z285</accession>
    <name>A0A010Z285_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formyl-CoA:oxalate CoA-transferase</fullName>
            <shortName evidence="1">FCOCT</shortName>
            <ecNumber evidence="1">2.8.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formyl-coenzyme A transferase</fullName>
            <shortName evidence="1">Formyl-CoA transferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frc</name>
        <name evidence="3" type="ORF">CryarDRAFT_2654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>formyl-CoA + oxalate = formate + oxalyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:16545"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:57388"/>
            <dbReference type="EC" id="2.8.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family. Frc subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850903.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2618"/>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_11"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="UniPathway" id="UPA00540">
        <property type="reaction ID" value="UER00598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033608">
        <property type="term" value="F:formyl-CoA transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00742">
        <property type="entry name" value="Formyl_CoA_transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017659">
        <property type="entry name" value="Formyl_CoA_transfer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03253">
        <property type="entry name" value="oxalate_frc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="408" mass="43932" checksum="E3B96729F768B744" modified="2014-06-11" version="1">MGKALDGIRILDMTHVQSGPSATQLLAWLGADVIKLEAPGRGDITRGQLRDLPDVDSLYFTMLNCNKRSITVNMKSDDGKEIFTKLVGEADVLVENFGPGVVDRFGFSWERLQELNPGLIYASIKGFGPGRYAGFKAYEVVAQAMGGSMSTTGYEDGPPTATGAQIGDSGTGVHLVAGILAALYQRTSTGRGQRVQVAMQDAVLNLCRVKLRDQQRLAHGPLGEYPNDNFGDEVPRSGNASGGGQPGWAVKCAPGGPNDYIYVIVQPTGWAPIAKLIGRPELADDPAWNTPKARLNKLDKMFALIEEWTEKHTKWAVMEDLNAHDIPCGPILSTRELIEDDTLAQLGSVVEVDHPERGAFKTVGMPIKLSDSPVEVERSPLLGEHTDQVLAELGLADRADAYRAAGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2A6</accession>
    <name>A0A010Z2A6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2636"/>
    <dbReference type="HOGENOM" id="CLU_040538_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="274"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="43143" checksum="5BF8496704CF1084" modified="2014-06-11" version="1">MVRDPGPPVSAPRRVPLWRRPFPEPPDVLRRGPFAPGAIRPAGRSAALSARLGLWLGAAFGICLVTGLISHGIQHPPDWFVWPRRPVSLYRVTQGLHVATGLATVPLLLAKLWAVYPTLFRWPPVRNGADLLSRAALLVLVAGAVFQLASGVLNTARQYAVLGFGFPAAHYWTAWITTGALVIHIGAQATVVRRVLRESRSATPAPVDGAVVTRRAVVATVAAAAGVVTLATVGQTVRPLSKLSVLAPRRPGLGPQGLPVNRSAAGAGVVAAATRDDYRLVVAGPRPLRLGRDALAALPQHTAELPIACVEGWSATARWTGVRLRDLLAEAGVAPGADIRIESLQRSGAYRVSTLPAAFAQDPLTLVALRLNGETLDLDHGYPCRLIAPNRPGVLQTKWVAWIGAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2Q7</accession>
    <name>A0A010Z2Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, linocin/CFP29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851135.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2784"/>
    <dbReference type="HOGENOM" id="CLU_089875_1_0_11"/>
    <dbReference type="OrthoDB" id="1252793at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28513" checksum="55E1E126AD8D6D28" modified="2014-06-11" version="1">MNNLYRELAPISDAAWADIETEAKRTFTRHVAARRVVDVLGPSGEELSAVGTGHLTELTAPAEGVLARKRVVQPIVEFRVPFVVDRQAVDDVERGAKDSDWQPVKDAAKALAFAEDRAILDGYAAANVTGLRPGSSNSAIALPADVREYPNAVAQAITALRLAGVDGPYSLLLSAEAYTAVAETADHGYPIHEHIARVLRDGEIIWAPAIDGAVVLSTRGGDYELHLGQDVSIGYLSHDANSIELYFQESLTFIVQTTEAAVNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z338</accession>
    <name>A0A010Z338_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase,'ATPase, histidine kinase/DNA gyrase B/HSP90-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2905"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="337" mass="34047" checksum="07B3C970CB5C45A5" modified="2014-06-11" version="1">MLAGALGVVITAGAIRVSWGGSYWVFGAVVGALAIGGAVAGLRYPVFLLAGTAILVAASAGLPREPGPATVLALGVVVAAAAREAEVGVPAAGLAVVAAGFVAGGATTVPVLSATGWVGAVGVGLGLRAFDVQRRAAREAVRREERLELARELHDVVAHHVTGIVVQAQAAQLRSAPPGSVPGALAGIEAAGTEALAAMRRLVGVLRSPGDAGQAATAPEELDALLDRWRGPRLRRDVAAGEWPAEVRSTVYRVVQEALTNVSRHAPGAGSVTVSVAADERELVVDVTDDAPAVSSRRPRGGYGLIGMRERVESLGGVVTAGPRDAGGWSVRATIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z342</accession>
    <name>A0A010Z342_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor, sigma-E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="164" mass="18737" checksum="5D5BAB8797272A14" modified="2014-06-11" version="1">MPLGFDDYVTERGRALLRFAYLLTGDYHLAEDVLQEALAKVHGRWSRLRRDDDPNAYVRTAILRQYLSWRRRRSSGETPSELTVDAPGGTDYAETLAQRDALWHALSGLPRQQRAAVVLRFYEDLDDDEISRLLNCSVATVRSHVSRGLARLRDEIHTVGGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3Y6</accession>
    <name>A0A010Z3Y6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851682.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3199"/>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="834"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="901" mass="95593" checksum="5B74112EF179173C" modified="2014-06-11" version="1">MTSPPIVIGRAAELGELDRLIRELPRGGGVLTLEGEAGIGKTALVLAAARLAGRAGYRVLSCGAVGVEAAVGFDGLRRLLEPVLGRAEALPERQRVALLTALGRCEGPAPDLLLLGLATLRLLEEVAAERPLLLVVEDIRQIDPSSLDVVGFVSRRLTNTPILLLATQRPAAGADAPPLAGPVLRIARLSEAAAGEVADQLGVTPDTRRMLLDRAAGNPLALRELATAVHQHGLTSVTGVPEHLPMTDLLERTFVGQISEFPESTRRMLLVLAAAEDLPLIDVLAAARRFAVEPEDLDVAETAGLIRISGDRAVFRHPLVASAVYRAGDAAERDAVHRALSETTVDADRAAWHRALATHAEDESVAAALASAGQRARRRGALADAGRALCRAAALTASGEVRAARLVEASEAFRGAGRWYDAVRAGQEAIPLTTDPALLVPLAQTYAMMSDLGVPGDVDQAVFDEILGRLPSDQGRVGVLSAAAMAAVSRFEPRASIREALEPVGRSIDDPLLIAVLTVLDPVRYATRFRQQFSGAIRSTDDPVHLMVLGRAAEAVHDVPGSVQALDRAVDGFRRAGSPRDVCLALARRGRVRLAAGLLTAADGDLRASLRVAEDLELTTIVASAVVALARLRLRRGDSTAATDALSREAELVGVHPRRPLAADFAWTRGLLALAEGRAGDAWERFRAVSVDRETSRWALADLVEAGIASGRGDEVQDFVEDAAREAAVFRSPHLTSSVHRSQALLGSGVATDALYQEAIRIGREGVGGLELARTHLLYGAWLRQQRRVVEAREPLTDALQEFDRLRVAPLAERAAAELRAAGVSPARDGRAATVDAAAVLTPQELQIARLAAAGLTNREIADQVFLSHRTVGAHLYRIYPKLGISTRNELAGLLGRSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z477</accession>
    <name>A0A010Z477_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2449661_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="89" mass="9556" checksum="2B89C750664A2F4F" modified="2014-06-11" version="1">MLLPMTTIMVILAIGAAGVGMIVLAAVLNRRARLAREGRSVDLEAVRAEVLAALDRGDPIGAVKVYRYETGLSLVEANDAVQRIAINRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4Q4</accession>
    <name>A0A010Z4Q4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="151" mass="16113" checksum="1F02B7F31BFBD5D4" modified="2014-06-11" version="1">MSVFTTPDDQPVYRLLNSDARMLATGRQTGGDLTVVESTGLRGHSTPRHRHLLATETFVLLDGEMLIQVGDERREAAAGHVAVLPRGIPHSFVVISPSVRYLTLHSPGGFDEFVRELSEASAAGGPTDPGALMAVAARHHIEMLGPGISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4U9</accession>
    <name>A0A010Z4U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852126.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3509"/>
    <dbReference type="HOGENOM" id="CLU_116759_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458079" evidence="2">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="205" mass="20846" checksum="44D4E0D54F14BEEB" modified="2014-06-11" version="1">MIRWTVLYVRSRRLPAAVAFSAVAVAVVAGVWRLFSDSPATPANLAVGVGLLALAPLIPTLSGDDDALESTAALPWPPRRAAHLVALFGGGVALLTVAAALGIEFGTGWQIVRNGAGLTGLIGLGAALTGAQLAWLVPVVWTGIQVMGAAAAAGGVERQLLFWQLQPDSSRAAAVVAVVLAAAGLLTYAIRGCPRRSPGEVTVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z522</accession>
    <name>A0A010Z522_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864303.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3595"/>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21539" checksum="87085851A145D44A" modified="2014-06-11" version="1">MTRYTVRDVMSDEVATVVVDAPLATVATLLGRRRISGVPVLDGEDRVVGVVTVNDLLHTMTGHQDTADVRARDLMTAPAVTIDPDASIVEAAAKLEDTGVGRLPVVDRDGSLVGVVSRGDLVKVFTRPDEHILGEITEDVVADLLLIPPELLTITVTDGVVTLRGHLEKRSQATQLVALSRRVDGVARVVDELSHGTNDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5M6</accession>
    <name>A0A010Z5M6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852576.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3815"/>
    <dbReference type="HOGENOM" id="CLU_057862_2_1_11"/>
    <dbReference type="OrthoDB" id="922937at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="29758" checksum="F78F06D376A4EABD" modified="2014-06-11" version="1">MEKRELGQFLRSRREVLTCADVGLPVTGRRRTPGLRREELAMLAGISTTWLTYLEQGRDVRASDQVLASLTRALRLSPAERAHVYALAGFPGPAAPAEPLAPHVGDVAGALGLHPAYVTAADYTLLTYNAAAEELFTGLPRIGNLARWLFTDPAARDLLPDWTEIAQDVLARLRAAQGRHPGEERFTRLVADLHEASPEVRDWWPRQDVRATRSGTKRVRHPRRGVLTLSYVSFQVADHPDQTLVVYLDPGAEQDESARSASGRSLDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6B6</accession>
    <name>A0A010Z6B6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_4039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852822.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4012"/>
    <dbReference type="HOGENOM" id="CLU_009432_0_0_11"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="413"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="628"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1056" mass="112728" checksum="9F4EECD99922B10E" modified="2014-06-11" version="1">MNIADVVVPSQPALSADGTRIAYVLRTLDTDQDRNVDQLWLVGTDGGAPRRLTRGPSDTAPSWSPDGRRLAFLRDGQIALLDLDGGEPDRVTDLPLGAGAPRWSPDGTRLAFTAPVGDTGGPMVSDGLDYQADGSGFHGAVRRHLHVVDLGSGDVRQLTDGGHDVGAVAWSPDGTTLAFTRKHGADSDLRHRTPVFLLEVDAPHARPRLRAFADGVASAVDWAGSALLVTGWTGDPRGHARLYRVDDEVTELAADVDRNVMPGAPAYPGGLPREADGQVYFCLRDHGCTHLWAVGLDGADAHAVVAGAGRVVSGLSIAAGRAAITLATPTSFGEIVVVDLATGAETVLTGNQVELHRREERWFTISDGTRVQGWIMRDPAASGPRPLVLDIHGGPHNAWNAAADEMHLYHQELVDRGWAVLLINPRGSDGYGEALYDSINGGWGLADAADFLEPIDQLVAEGFADGDRLAVTGYSYGGYMTCWLTAHDYRFAVAVAGGTVSDLVSISGSSDDAHFLSVYELGGPPWQKPAEYAAMSPLTHVSDVRTPTLLLHGADDLTCPVGQAQQWHTALRQLGVPTRLVVYPKASHAFVLLGPPSQRVDYGRRLVDWISEHTTGRARVDAAHWQDRLARLADRHQVPGAQLGILSGDQLVELAHGVLHTGTGAPVRTDSVFQIGSITKVWTATVVMGLIDEGALTLDTPVAEIVPELRLADPEVTKAVTVRHLLTHTSGIDGDVFTDTGRGDDCIEKYVEQLEEVGQNHPLGVTFSYCNSGYSLLGRVIEKITGLSWDQALRERLFTPLGLTGTSTLPEEALLSSAAVGHHDGKPVGTWMLPRAIGPAGLVNSTVADVLAFARAHLTGGLISADSAAAMAAFQADLPDKQILGDSWGLGWIRFDWDGHRLIGHDGTTLGQAAFLRILPSHGLAVVLLTNGGHGRDLYEELFREIFGELAGVAVPRPFAPGSYDGDVTPYVGTYQRAGVRMEVEADPPLLRTTIIGPLAELEPNTVDEYTLVPSGPGVFAVKPPEAENWMPVTFYSLPSGEPYLHFGVRATPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6C1</accession>
    <name>A0A010Z6C1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4017"/>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="33956" checksum="1DFEA8500DC1BC6D" modified="2014-06-11" version="1">MLSSGIYVVQYLIPIVFMPMRPSLELRWVAYFVAVAEAGTVSAAADAVRVAQPSLSRQLRALEQDLDVDLFDRAHGRLRLSPAGRALLPYARELLARADALRAAAELQVRGRLTHVTIAAPTTTLTDVVSPFLVTLTPDDPVPAVFVSDGNTVDDALRRGADLVITAEPPDRRRSFHPLPPLPVWAYVPPGHALAPPGPLGAAAATGPGGPGGSLDAAALVGEALILLPAGHPARDAFDRAIGVPATIEASNGTVAQALAAAGRGVAVVSDDPRYDLVPLAVVATDGTPVSVRLACAWDPGHPAAPALAGLAARIERYVVRHYATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6J6</accession>
    <name>A0A010Z6J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4105"/>
    <dbReference type="HOGENOM" id="CLU_060897_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="28961" checksum="DE57F93F1284100B" modified="2014-06-11" version="1">MSTSPVVILTALDVEYEAVRAHLIGPRSYRSVTDTEFEVGRTAGGHQVVLALAGRGNQAVAVIGERAINAFHPAAILFSGIAGGIQPQLSLGDVVVATHVYPYHGATSAGSGLQARPHTLQIQHGADQVAHRVARAGTWANPKLSGRPTVRFGPIAAGEVVHYASESDQMRWIRQHYNDAVAVETEGAGIAQAAHLTRSLPVVVIRGISDLADDTKQATDRAGWQAVAAANAAAFTLTLADELARRRTDRSAISEERSMNLSNKNIAKNSTVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK61</accession>
    <name>A0A010ZK61_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859795.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.62"/>
    <dbReference type="HOGENOM" id="CLU_123836_1_0_11"/>
    <dbReference type="OrthoDB" id="1867074at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="111" mass="12475" checksum="CC1FE4077D86B16C" modified="2014-06-11" version="1">MSRERFEELVGDALDAIPEELLKRMSNVVVLVEDDAPERGLLGLYEGHALTDRGWDYAGVLPDRITIFRNPTLAICSTEQDVVEEVAITVVHEIAHHFGIPDERLHELGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKA4</accession>
    <name>A0A010ZKA4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847524.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.102"/>
    <dbReference type="HOGENOM" id="CLU_019886_0_0_11"/>
    <dbReference type="OrthoDB" id="989319at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="568" mass="60997" checksum="AB1AE799F70E43E3" modified="2014-06-11" version="1">MDGPRLAEALEALRTSVTAVRLDLAVTDAEAARRSRSEFVGQVDDYLLPRLRQLDAPMLVAVGGSTGAGKSTLVNTLVGAEVTKAGWLRPTTRAPVLVCNPDDVSWFETDRILPGLSRTTGPEAVNSLRLVPHPSVPPGLALLDPPDIDSVVAENRDLAGQLLAAADLWIFVTTAARYADAVPWDLLHTAAQRTIALAVVLNRVPPEGIGEISDHLRSMLAEERLGEAALFAIPEVELTGKRIPDQAIAPMRTWLDGLAADAGARDQVIRTTLTGALSSLHDRVTGLADHLDDQVRAAAELRGTALERYRTALTGVDDGVRSGTVLRGEVLARWQEFVGTGQFTRNLEARIGQLRDRVTSFFTGRPPAAEAVGHAVESNLHALVRAASDQAAEQTTELWRSRPAGRALLTDGLHRSSAEFGPRLEHEIRAWQERVLDLVREEGGHRRSVARLTSFGVNGAGLVLMLAVFAQTAGLSGLEVVVAGGTSAVSQKVLEAIFGDAAVRTLAARARDDLLDTVEKLLTDERQRFDALVDAVAPATDQVTALRSALAEFESALRSYLRQPGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKW1</accession>
    <name>A0A010ZKW1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774289_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458335" evidence="1">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="15243" checksum="3D202F4007EC5E0A" modified="2014-06-11" version="1">MHLSRRPGALTPLAAVVVPVLAAMLSVLVVGACSKGGPGGEASESPTTMASATAGTDGVQSITITGDDQLRYEPSVIRAKPGKLRITLRTIGGTPHDLEVRPAKINTGLVSTDQERSIEVTLSRGRYDFVCTFHLTSNMVGVIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLZ2</accession>
    <name>A0A010ZLZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848453.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.708"/>
    <dbReference type="HOGENOM" id="CLU_074078_2_0_11"/>
    <dbReference type="OrthoDB" id="1635544at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="15998" checksum="7872359D4CA26EAE" modified="2014-06-11" version="1">MRILGGSDAEEPASIRPYLKASSLSPSGETPNKASNVGSEASGAQLRPFVLTSGRVTADPEIGLETQVTAGTRGGRVPTSRLSPELRAIVTLCAQPISVAEISARLKLHLGVVKILVGDLRATGYLDVHNHDVSSPNSPELILRVIRGLSAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLZ6</accession>
    <name>A0A010ZLZ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2463884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="88" mass="9820" checksum="4F6D113392D418A1" modified="2014-06-11" version="1">MNATSRPRTGRPRFTVSVDIDLDGSWWVVRKPADLHPRDFANVRGKVRPLHAKSSRTCHPSVSHFAVTHAAWSLARPSLVIEPSLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPD5</accession>
    <name>A0A010ZPD5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725678.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1595"/>
    <dbReference type="HOGENOM" id="CLU_090613_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="24503" checksum="4986C850BA7B5268" modified="2014-06-11" version="1">MRHHVLTTIAGYLATRHRSHPLRVGVDGICGVGKSTFARELRAALAETGRPVVLVDSDGFHHVRERRYRQGRDSARGYYEDAYDFDALVTDVLVPLGPGGSRVYARRVHDMATDEVVVGDTAPCPPDAVVLFDATFLQRDALRAHWDEVVYLHADVETATGRGVARDAARLGGPEKARAAFAGRYTAACRIYLDEQRPRERASIVVDHNDPDRPFVERMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ86</accession>
    <name>A0A010ZQ86_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1882"/>
    <dbReference type="HOGENOM" id="CLU_054974_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="26324" checksum="4B19889561CAF250" modified="2014-06-11" version="1">MSNPRLLVVRNDAEDDARRLGDWLVEAGADLHVVNADAGDALPADLTGYDGVVVLGGAQAAHGEPASPWFPALKALLREAVHERVATLGVCLGGQLLADALGGRVEPAANGPEIGAFLVAKRDVADTDPLFAMLPFTPDVYQWHVDEITVLPPGAVLLASSPRVPHQAFRIGPKAWGIQFHIECDQAMLASWAAGDDGSLERAGLDAATVLARCAAVETDVEEVWRPFAARFVAVAAGRGAGPGVPLPVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQB4</accession>
    <name>A0A010ZQB4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849973.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_4_0_11"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="72" mass="7913" checksum="25DB7A5AF0FC658E" modified="2014-06-11" version="1">MTPDLILDCLGLRCPLPVIHLARRIGEVEVGGVVRVLADDPAARNDVPAWCRLKSHEYLGSDGTAHDVRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQP8</accession>
    <name>A0A010ZQP8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873502_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="318" mass="33205" checksum="6A36653D4EF17E1A" modified="2014-06-11" version="1">MGRHRAALGPVIGRHPEPHKAGLQRVAELWCGPSSSGVRAGGGYVTEQFSGGSACGCAVLRAVIGWCPGRWLGGAAGLLSGAAQRVAGERPKSSSGRALHVSGQRPGHRRVAFGQVVPLSCRPSKLQSVVGRCAGSELGGSPARNRVVSRPGGSVVPPTRHSAGAPPCDRAVARLKSSRLPARDRAVRRLSERAEPAPAGRRSPRARISAPTSAGPAHPRSRPRNKRPNTLGRSDARTLGRSDARTRLCGGIEHRYGHPAHPRRPEDGAATTYGAAGRLGRSPRRPVAEATGLRPAGVIRAFRRPPAATETCAGTRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQQ1</accession>
    <name>A0A010ZQQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850151.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710212_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="15881" checksum="A06840384309D151" modified="2014-06-11" version="1">MPIDRNQAFEALAQVRARQRAVIAASVVPDGYWAAIAAVSTLYAAAIESHVPVLQAIGGVVFAVGMTGSVLWAVFHSGVRQRRGLLTGADVVSVFLFVLSVAAIGAAVAIALTSADVRFAATIGIGTAEAVMAVTGPILNRRLRGVMLRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR20</accession>
    <name>A0A010ZR20_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate decarboxylase (ADC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127578_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="22722" checksum="A043738D0FB3B08C" modified="2014-06-11" version="1">MIPSVPESLLATDVVLPESSAPAPWRTKIDAAFWWHRASPDAAAQLPVELRALGTIPVTLVAFVRYRESPVGPYSEVFASPVLLRQWPVPPLHVPFIAVDSLASVHGGRVNWALPKAVASFTWGSSSIAASGDGWDVAATAQASTPKFPVAGGLKMTQLFDEGPRSAWVGLYGRARLGRVTVAASGPTLSSWLLPGRHPALIISDSTMNISAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRQ2</accession>
    <name>A0A010ZRQ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2377"/>
    <dbReference type="HOGENOM" id="CLU_1479724_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="182" mass="18847" checksum="AA5E5C8F334B6CDC" modified="2014-06-11" version="1">MPAVAAEQSQGGGSILPLLLLVGVFALMYFLVIRPQSQRRKQMTQMQSTVEEGAPVMTLGGLYGTVVTADSESVVLEVSPGVTNRYARQAIAKVLSDEEAVKAGLAPNEAESFDDAVDEDDVPVTDAAVVDTTPAVDTTPAVDTTPVVETPAPKAPEAPAAPSDPTADPRPASGADSSTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRQ7</accession>
    <name>A0A010ZRQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570056.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2388"/>
    <dbReference type="HOGENOM" id="CLU_005108_5_0_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="202"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="719" mass="77143" checksum="007A6BEF950035E0" modified="2014-06-11" version="1">MFARLGRFCYRRRKLVVVLWLLVFVAGIANTGRVTDRLGGGQQASESMESVLAARLLADHSEFGGRVSAVVDGAPVETLETPIADARDDLGRTDGVGRVLDPFSPQLPEQGRALFVADDRNAALIVVDLRRDLSVDAQHRIEQAIADRLHAIPGVRVTVGGPALLQREINEQTRRDTEKGELIALPLTLLAMVAIFGGAVAAGIPIVGALASIACGMLVMLGLLRLMDLDPNVLSVSTVLALGLSIDYALLMVNRFREERYAKRTVPAAIERTVASAGRTITFSALTVALSLAGLFVFPSPIFRGIGAAGVGVVLFALLAGVTLVPALLGMTSRRVGVGRHRPERPSDDGTFARLARLTRRRPLVATVLLTATLLATGLPFASVTFVNSSANLLPEGFEARRFAEITADRFPGQDAPPITVVASTSRGELALWAARLPGEYDGIARVMPPTQVTEGLASIDVVPEASGHDRIGRRLVGEIRADRPPFRIWVTGETAVLVDFLAEVRRYAPWAVTLMVVATFVLLFAMTGSLLVPIKALVMNVLSLAASFGALKLIFQDGHLHGFLGFTPTGGLEPFVPVLVFCFAFGLSMDYEVFLLARIKELRDAGMDNDRAVEIGLQRSGKIITSAALLMIIVFAGFAAGRMLAIKELGVAMAIAVAVDATVVRCLLVPATMALLGEANWWAPKPLRRLHERYGLREAPPDERQAFDGFPSTPASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRR5</accession>
    <name>A0A010ZRR5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">CryarDRAFT_2435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2398"/>
    <dbReference type="HOGENOM" id="CLU_057607_3_3_11"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="165" mass="17017" checksum="910F55706DCEB427" modified="2014-06-11" version="1">MLVGPPGAGKTTVGGLLAERLGVTFRDVDHDIEASAGKPISEIFVDDGEPAFRALEVAAVAAALGSHDGVLALGGGAVLAETTREALRGHRVVHLNVGLSDAAERVGLNTARPLLSLNPRATLRTLLAERAPIYAEVATIAVDTDGRTPEDIVADVVEQLNEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRW4</accession>
    <name>A0A010ZRW4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">CryarDRAFT_2503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570074.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2464"/>
    <dbReference type="HOGENOM" id="CLU_008831_0_0_11"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="185"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="32135" checksum="5298B1820935620A" modified="2014-06-11" version="1">MSRQALIVTHAGRALNVVHARRVAAQLSAAGFGLRVLTDEAPDLNIDAQVVRPDEKAAVGAEIVFALGGDGTVLRGAALARPAGAALLGVNLGRVGFLAETEAEHLDETVRRVVEGDYVVDERMTLELTVGRPDGTTAHGWALNEASVEKAMRERMLEVMVSIDGRPLSRWGCDGVVCATPTGSTAYAFSAGGPVVWPDVEAMLVVPISAHALFARPLVTAPTSTIMIEVLAEGVPAVVSCDGQRVVAMPPGSRAVIRRGSDPVRVVRMSPRPFTDRLVAKFGLPVQGWRGDAEAARNERAVGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRX3</accession>
    <name>A0A010ZRX3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">CryarDRAFT_2513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850699.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2474"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_11"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="312"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="569" mass="61496" checksum="764C2490BB1C886F" modified="2014-06-11" version="1">MSLSSQATTHVFVTGGVASSLGKGLTASSLGNLLSARGLRVVMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDTQLRANANVTTGQVYSRVIAKERRGEYLGDTVQVIPHITNEIKERIRGMAAAGPDGVVPDVVITEVGGTVGDIESLPFLEAIRQVRHDVGRDRVLFLHVSLVPYLSPSGELKTKPTQHSVAALRNIGIQPDAIVCRSDREIPEGLKRKISLMCDVDADAVISCSDAASIYDIPKVLHREGLDAFVVRRLNLPFRDVDWARWDDLLDRVHRPHHSVTIALVGKYIDLPDAYLSVTEALRAGGISNYAKVDIRWVAADKCATPAGAAAALADVDGVLIPGGFGVRGIDGKLGAITYARQNRIPTLGLCLGLQCMVIEVARSLAKLEGADSAEFTPDSPHPVISTMADQKDVVSGDRDMGGTMRLGAYPAALTPGSLVADAYGATSVSERHRHRYEVNNAYRKQLTSVGLEFSGTSPDGKLVEFIELDREQHPYFVATQAHPEFKSRPTRAHPLFRSFVAAALDYDNASRLPVEVPVQDTPAGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS53</accession>
    <name>A0A010ZS53_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848820.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591774_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="3">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="167" mass="17502" checksum="6C798C37A8E00AB4" modified="2014-06-11" version="1">MRGPAAAHAGGTRREAARHDSEGPGNRAAATRRPARSHDDGSLTPLVLLCTLLALLLIAGATTASSAFLAQRNLQAWCDSAALALASDVATISAYGAEPTPDQLAAELRTYLGGIQNEGAITRLSVQNDQITLICTHTAVLPFGRLFGIPDGIERVVMSSARVRWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZS99</accession>
    <name>A0A010ZS99_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848883.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524440_0_0_11"/>
    <dbReference type="OrthoDB" id="610575at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002723">
        <property type="entry name" value="BpsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01861">
        <property type="entry name" value="DUF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF43" evidence="1">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="538" mass="56055" checksum="6A048D4E2363F4C1" modified="2014-06-11" version="1">MSADAVAGVISEHGRAVRAVVLALGERGWTLADLVRAFAVPRRTVEEVLSALGDDLAPGGELRIRAERAAEYRRRFDRRTTELADPLGPALATVPDLLAQVTRLRASAPPPRRALDHVAATPETAVRRALWLDAHFDLDGAHLLCVGDHDLTAAATCLLRPSLTATVVDVDERLLAFIDSLGLGIRCVFGDLRFGLPAAAAGRAGLAFTDPPYTPEGIGLFLERAIEGLVPGGRILLAYGFSPRTPALGLAVQRTFGELELAVQAQWPAFSRYDGAQAIGSASDLYLLLPTSKAHRKGRAKPTIYTHGEQSAEASSAAPGEVAAALVSAASGPDRLPVLGAGPTPGALRTAGPTAPELSGERPLGALWTGGVPAPARSGAVAVDASADPGSWLLRVLLAVDARRLAVAVGNNHPDLADAAGQQALAELVAPKWALRFRRSTPGPASAIVEAVAAPDPADRGDRLVRHVLDRAHGRLANVWRDALVTHAGLTKPQAAARVAELLPTPAGIEADGALMEVPRHRLGPLFAAVRASVPNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSA8</accession>
    <name>A0A010ZSA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850921.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2642"/>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="119"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="342" mass="35179" checksum="48AEEFE3125922CA" modified="2014-06-11" version="1">MRDVLVICALALGSSGAVASFGLAALRILRGRSVTAHLGVLLAVTVASVVTGVVVVAEAMFLSAHDLGVVGMVLIVSGVVSLGFALVAGRRLARASVWAAEARAREQALERSRREVVAWVSHDLRTPLAGLRAMAEALEDGMVEPDGVPGYHRRIRLEADRITALVDDLFELSRINAGALRLTLDAVPLGEVVSDAVASATPVARAKGVRLVADHSSYGVVRGSEPELGRVLGNLLVNAIRHTPQEGIVTVVGGSDEGTGWVAVSDECGGIPADDLPRVFDTAFRGESARTPAAAGDPLGSGGGLGLAIARGLVEVHGGRIAVDNTPGGCQFTVRLPAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSB2</accession>
    <name>A0A010ZSB2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850932.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2647"/>
    <dbReference type="HOGENOM" id="CLU_109304_1_0_11"/>
    <dbReference type="OrthoDB" id="1950808at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DUF1992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="1">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="130" mass="14850" checksum="F9188779A5CAAD43" modified="2014-06-11" version="1">MAQPTGPIESWVERQISAAIERGEFDDLPGEGKPIPGIDDPPDPLWWIKRKMKREGLSVVPPSLALRKEVEDALEKAEAAHREQEIWDLLEPINKKIRAAIRVAPVGPPLNLMPIDIDRVVRRWNERRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSN3</accession>
    <name>A0A010ZSN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851136.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2785"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="418"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="507" mass="55399" checksum="9D3BFE84FCD351F7" modified="2014-06-11" version="1">MYPGAYVASSPDKPAVVMEDDSEILTYAQLEERSVRLANAFRDAGLRPGDVVALLTENSPRVFEVYWACLRSGLYLTSVNWHLAKPEVAYILEDCGASALVASEGLLPLVEGEFPALHTRIQIGGSTRDGYRDYEELLASSSPEVPADQPRGGDMLYSSGTTGRPKGIKPHLPERQVHEPGDPYVGVFGPLYGFNQDSVYLSPAPLYHAAPLRFGMVVTSLGGTVVVMPSFDAERAVRAIAHHRVTHSQWVPTHFVRMLRLPVSVRGGFDLSSHKTAIHAAAPCPVEVKRQMIEWWGPILEEYYASTEGAGGTFIGSEEWLKHPGSVGKPMIGIPRICDDAGQEVPIGTPGLIFFERDDLPFVYHNAPEKTRSAQHPEHPTWTTVGDVGYLDDQGYLFLSDRKAFTIISGGVNIYPQEIEDALLQHPAVLDVAVIGVPDPEFGESVLAVVQLVASASASDDTRASIAEFAREQLAGFKVPRRIEFTDALPRTPTGKLVKGKLREEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT30</accession>
    <name>A0A010ZT30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="9" type="ORF">CryarDRAFT_1440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849219.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1414"/>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_11"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="427" mass="47031" checksum="8B7B3467E23B7757" modified="2014-06-11" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELSESSELKWDELPKPIEICEFLDQYVVGQDSAKKALAVAVYNHYKRIQADNTNHRNGGPEPVELAKSNILLIGPTGCGKTHLAQTLAKLLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKIIENRVGKNGLGFAANIISASERTTDDVFAEVMPEDLLKFGMIPEFVGRLPVITTVRNLDRRALMQILTEPRNALVKQYQRLFELDGVELDFTRDALESIADQAILRGTGARGLRAIMEEVLMSVMYEIPSRPDVARVVISREVVLEKVLPTIVPRDVPKRERREKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTB0</accession>
    <name>A0A010ZTB0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569889.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1505"/>
    <dbReference type="HOGENOM" id="CLU_041115_1_0_11"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="173"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="314" mass="30790" checksum="00577EBCB937736A" modified="2014-06-11" version="1">MRELGRTVAEWLGAGHRVAVARVVDVHGFGAVPAGEVLAVRDDGARAGELLRGVADPVISGAVPAALSGAPSVVNAPVGESDAVAAGLACAGSARVLVHAVSDASVWTALAEGSPVALATSLVSGESTVPGSPDGPDGAVAAEASRLLAAGATGRSVVGDVLVDAWVPTPSVVTIGGGVLAAAIAAQAELLGWAARNVSTVSEAVAEVAAFGPADVLVLLDHDPAMDEVLRVGLSHGRGFLGALGSRRTQAARRERLLAAGVPADAVGRVHGPVGLDLGARSPAETAVSIVAEVLATRSGRGGAALRASDVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTE1</accession>
    <name>A0A010ZTE1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569894.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1539"/>
    <dbReference type="HOGENOM" id="CLU_896347_0_0_11"/>
    <dbReference type="OrthoDB" id="1726632at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="310" mass="34132" checksum="E4FE8D4E4844C3CC" modified="2014-06-11" version="1">MAWGVHELLALLSVEHDFHRRWEIRCNIAKAPDAAAVLRGIRRHGPSRLRAAALDALMHLEGESGLDPKDVAAVERLIRIRQRNDVLTPVMSIETTWWCIRELDQATVMASLGLTSPRPVTYKLANSVMEIIDSDDESGLVYVGPEINGWAPVVGPWCDAFGDRAEEARSTVERLSADSGEVHAFSFSAYNNGTAWLVARNGVTIRRFSTFDPQDSTGDPLPIEQDWMSARGLPGRPEDHCRYNDHGVLVYVGEFADMMEDFYQANDVAAAVSVDVGWKHPHDALIHGSPVLAAVPDAGPVTLPPGMYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTH2</accession>
    <name>A0A010ZTH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849461.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1574"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_11"/>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="14"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="510" mass="54277" checksum="2C12D1EEE1373F2B" modified="2014-06-11" version="1">MTARLSALAAVPGDRGRITVECPVDGEPIGDIPRARPDDVASAAARARAAQAAWSQVPVAERAAVVRRFGRSVLTRQAEILDVIQRESGKSRADAFEEVLDVAQVSRYYAAVGPGLLRTRRRRGAIPALTVTHEVRHPKGLVGVLSPWNYPFSLGISDALPALVAGNAVLAKPDHLTPFSCLLAKELLAGAGLPEDVFTVVTGIGAELGEAVVGCVDYVMFTGSTRVGRLLAARAAERLTDFSMELGGKNALLVRADADLGLAVPGAVRSCFANSGQLCVSTERLYVDTAVWDDFVPRFVDAVRDLRLGHGLDWSYDLGPLMSTRQLGTVQRHVDDAVTRGATVLTGGKARPDLGPTFFEPTVLTGVTAAMEAFAEETFGPVASLYRVDGDDDAVARANRSEYGLSASVWTRDHARGERLAARLRTGNVNVNEGYAATWGSVDAPMGGWGASGTGTRHGAQGLLKYTNAQTVARQRLRNLSKPPGVRGEVYAGLMTWALRALSRGDVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTR0</accession>
    <name>A0A010ZTR0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1685</name>
        <name evidence="2" type="ORF">CryarDRAFT_2267</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3250270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="40" mass="5180" checksum="11E8E62AE4225DAE" modified="2014-06-11" version="1">MSDCYDYNQCNDWDYNECKPRRRRHHKKRYNDCWDYNPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTV5</accession>
    <name>A0A010ZTV5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3233"/>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="182"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="29057" checksum="DD9502AA8AC7F054" modified="2014-06-11" version="1">MTQERGLAILGAGVMGTGITTLALAHGIPVTLIDVSDEVLADARDRVRQQLRHAQLMGAVPGAVAALTTSTDRGAVGNAVAVVEAVVEDVEVKTSLLGDVCARLDEGTPLVTNTSGIPIDELAKAVGRPHELVGIHFMNPAYLITTVEVARGSATGDAAMDTITALLARMGRRGIVVRDSPGFVTSRLLHPMINEAARIVGEGVTSAAAVDELMQACLGHPTGPLRTADLIGLDNLADALRALADRTGIDRYRPCELLEEKVAAGHLGRKSGQGFYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUB2</accession>
    <name>A0A010ZUB2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851929.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802897_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="15115" checksum="FE239CB6A07143C4" modified="2014-06-11" version="1">MTNHHLDVPTPPEGIRLPPGHTYDQIHGANGDLLLAAYTRVDPGAHRATLQVLGEIDAVSVGWFRDRLAAAITEAAAVGHRPTIYLDLHSVSFFSAAAAGLLAGLTAAGSELVVHRPSRIVSRVLALTATLPLLRVDPTEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUF1</accession>
    <name>A0A010ZUF1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">CryarDRAFT_1917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849911.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1880"/>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_11"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="29740" checksum="1A6312DC4D2004EB" modified="2014-06-11" version="1">MMSEETSLYGGPSHRRVRARDLVAAKERGERWAMLTSYDQYTAALFDRAGIPVLLVGDSASNNVFGNETSLPVTVDELIPLVRAVSGAASRAMVVADFPFGSFESGPAQALATGVRFLKEGRAHAVKLEGGARVAPQVDALTGAGIPVFAHVGFTPQHENLLSGYRVQGRGDDADRIVEDAVTLAEAGAIAVVLEMVTSDVAKRVTDAIRVPTVGIGAGGYTDAQVLVWQDMAGLRTGKLPRFVKQYADMNAILDDAARRFAEDVREGKFPAEEHTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUI7</accession>
    <name>A0A010ZUI7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3475"/>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458086" evidence="2">
        <location>
            <begin position="35"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="406"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="54475" checksum="80BD0F3646807CA2" modified="2014-06-11" version="1">MPLLGSSPASRFGTALVTAALLLTGCTATSPAERKTTPITWSPCGTALECGTVPVPLEYTESDDKQIALTVMRHPATDPAQRIGTLFFNPGGPGYPATELMKTLDSPTGMFSPDVLARFDIIGVDPRGVGRSSGVRCLTDDQRADAVAADFDPAIPGGKPLPRLLADATAFTRGCADHQSRAFLASLSTDNVARDLDQVRAAIGEEQISFYGTSYGTVVGRMYATLFPDRVRQVVLDAPVDTGRWFGDPLAFLNEVAVASERTLDAWLATCRAEGVRVCPFGDGNPGAALDTLLTRLEAKPLPVKPVAGLTPGGTLDGARALEAVRAAAGAAVTWPVLTAALLGAQRGDGALLHFLWTAVTLSPFPVPTALNEVHTAVRCADWNTPADVAAHTAAARDVVEQAKRVGTRAAYSALNCARWPAPNTDRFTAPLTGAGAPPTLVIGGRLDPATPYHWAVATTATLESAVLLTREGVGHGSYRTSNSPCVDSAVDAALISRALPADGTVCTPDAPATTKPLATPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUS7</accession>
    <name>A0A010ZUS7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-type ATPase, translocating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3596"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="875" mass="91424" checksum="6E352351554282BF" modified="2014-06-11" version="1">MTTMLARDRSPVDGHDREATEIAALFEVRPDRGLTEAEAAARLDRYGPNELPEPTHRSPWLRFLDQFRSWLFAILFGAAVLAAAVGELGEAAVILLVLLINAVIGFVQERRAEHSLEALRQMLVATTRVRRAGAIRVVPARDVVPGDVVLLEAGDRVPADGRLTVAEAVDVDEAALTGESLPVSKSTTAVKKTVPVAERTSVLFMNSTLTRGRAEMVVTGTGMCTRIGAIAQQLRAGEEPPSPLQVQLDSLGRRLALLGGVAVVVYLVVELTLAGGESLSALALRSVALAVAAVPEGLPAVLAVTLALGVHRMARRGAIVRRLASVEALGSATVVCTDKTGTLTMNQMTARTLWFAGRRYRVTGEGYRPSGVITGGPAGGLPTALMPMVACNDAKLLADGGIAGDPTEAALLVLGAKAGLHAPVPRTGEVPFDAAARYMVTFHPEPDGRTRVYAKGALDVLLPRCSDVAGVGTLDAALERQVRAAAHEMADDGLRVLAGATAVVDHPGGLPDELTLVSVVGIADPPRPEARDAVERCRAAGVAVTMITGDHADTAAAIARELGIAGDVVTGAELDGLTEEELTAKVAGVGVFARVAPEHKVAIVRALAARGEIVAMTGDGVNDAPALHAAHIGVAMGRTGTDVAKEAAAMVLTDDDVTTIVRAIGQGRAIYDNVVTFVRFQLSTNIGAILALLAAPLLGLPAPLTALQLLWVNIIMDGPPAMALGVDPARSDVLRRRPRPVGERILSRSRLADVVRVGAVMAAGTLGVLALARGPFGDATAMSMAFTTFVLFQLVNVVNARAGRRTVFHRDQLRNPALWVALGAVLLTQIALVHLPWAESLFGTAALTTGQWAICGAVAASVVLIEEALRRITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUW0</accession>
    <name>A0A010ZUW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850144.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2057"/>
    <dbReference type="HOGENOM" id="CLU_088365_1_1_11"/>
    <dbReference type="OrthoDB" id="1565693at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="142" mass="15409" checksum="99AC67553B5F7C2E" modified="2014-06-11" version="1">MNKPALAQQLDLEPHPEGGWYRQTWRSPVSFVPAGYPGPRAAATAIYFLLAPGEESRWHVVRSDEMWLWQSGGPLTLRIASAPDADDVRSVTLGPDLDAGQQLQGLVPGGQWQAAAPAGETPVLVSCVVAPGFEYEDWQLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV46</accession>
    <name>A0A010ZV46_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570593.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3728"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="253"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="502" mass="53332" checksum="FC6388F494D593A2" modified="2014-06-11" version="1">MTIRGLTKSYGTSVVLRGVDLDLTAGRIHALLGPNGAGKSTLLGCLSGAVRPDSGTIVVDGETHEGFTPSSALRSGTAIIYQHLELVDDLSAVENIFLGSELRTRFGTVRRREQRRIAAELLARVGADFHPTRTLSSLTMGQKQVVEIAKALRHQPEVLILDEPTAALSARETEMLLALVTRLAHESGLAIVYVTHLLREVTAIADEVSVLRDGSVEWTRPKSELTLEILVEAITGTPVTGASAAGVAARPGEAGPPVLELVGFRAAGAAEVSLTIGAGEVVGVFGLLGSGRTNLIEALAGARPSQGGLRLAGRPLRLTSPRGARRVGIALVPSDRKVQSLFSSLSAQENVLMPHYRRLSRWLRRSGAEQRTFRAVAERMSLHPMAPGLAGDGFSGGNAQKLVMGRWLMDGSGVTVLLLDEPTQGVDVGARVELHRMIREFARESERAVVFVSSDVEELNVLADRIVVLAESRVAGVVPGDTSERDLLTLAQPAELRGSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVA3</accession>
    <name>A0A010ZVA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035864778.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3793"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_1_11"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EHN" evidence="4">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="380" mass="41679" checksum="5AEC950036F8B1A9" modified="2014-06-11" version="1">MTDLVRPFTVSIPDSEIEDLNQRLARTRWPDPETVPDWSQGVRVENARALVDYWQHGYDWRRLESELNAHPQFMTEIDGLDIHFVHVRSANPGALPLILTHGWPGSNVDFLKLIGPLTDPESFGGDAADSFDVVVPSQPGFGFSQKPTGTGWTVPRTAAAWAELMRRLGYSRWAAHGGDWGAAVTTALGAARPDGLLGIHLTSTLAFPAELPDALSPEQQEAVESRAYYTGPLGGSNHLHCTKPETVGFALADSPAGQAAWIYEKYQSKTDNRGLAEDALSVDAILDTIALSWFTNSAASSGRIYWENPSGSFTGPELTLPVAVTIFPKDVPRPPRDWVEDTYSDLIHYGRPDRGGHFAALEQPEILVDEIRTGLRSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVR1</accession>
    <name>A0A010ZVR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative naringenin-chalcone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850568.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2360"/>
    <dbReference type="HOGENOM" id="CLU_034992_0_1_11"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="216"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="349" mass="37005" checksum="89685F3B49E5FD1E" modified="2014-06-11" version="1">MTQLAAVHGVLPDYRYPQAELTDAVAEACGLDDNQRRFLERVHRSSGVATRHLTLPLEQYPLPDFGAANDAFLRGAIDLGTRAVQGALADAGLTVDDVDTILAVTSTGLAIPSLDAHLAGRLALRPDVKRTPIVGLGCAAGAVGISRLHDYVRAWPEQVAVLVTVELCSLTVQYDDRSPTNLVASGLFGDGAAAVVAVGPDRPVHGPTVLATRSVLYPDTLRTMGFDIGANGLKVVLGTEVPTLAEKHLRLGVDEFLAEHELTRKDITTWVCHPGGPKVLEAIESGLELPEGALGASWNSLRRIGNISSASVLHILRDTLVDRPPEPGTPGMLIAMGPGFSAELVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW13</accession>
    <name>A0A010ZW13_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase family M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850711.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1163874_0_0_11"/>
    <dbReference type="OrthoDB" id="1795129at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="23923" checksum="91920A8E489E5F5A" modified="2014-06-11" version="1">MLFALGRPIALAGLALAFVLGLIIRVLAIRAVQRRRVPAGWGTSRRAGGKLVDVRRDVDIFGLVAAVVGGTGWGKKVEDTGMAPAPVRVLLAGPIAVIAAAQAAFLAFVLASEPVSLATLNSSSVLRGEIGGGTSVQMFLLSLAVGLLCFGLLDLVPLPPLDGWGLLRHAVKRPGTGFQKARYWLEDQNVGIAILLAGMLLPLFRGIPLFLYILDLVTWPFLVLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWR1</accession>
    <name>A0A010ZWR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570142.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2744"/>
    <dbReference type="HOGENOM" id="CLU_111585_2_1_11"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="166" mass="18765" checksum="6FF719D3D3DF9D88" modified="2014-06-11" version="1">MTVEDGTSPTPGYCADTGTDYDVSQWDTREGCEVRQILDRVADKWSLLVIALLERRTLRFTELRRAIDGVSQRMLARTLRHLERDGLVSRTVYATVPPRVDYRLTDLGCTLHETIKSLVTWTEAHQSEIATARATYDRRTAAEQAEAERAAAERDAVARRVLTELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX34</accession>
    <name>A0A010ZX34_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851207.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2854"/>
    <dbReference type="HOGENOM" id="CLU_037628_3_5_11"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458288" evidence="1">
        <location>
            <begin position="29"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="46"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="320" mass="32840" checksum="EC8A9EDB0E95D1AD" modified="2014-06-11" version="1">MKKFAVAGVVVGLFLAVAGCSGTGQEKGADEASDLDLTYAIVTHGAPGDAFWDRVKSGAERAGKDYGVKVEYSSDADPAKQSQLVDGAVADKVDGVIVSMANPDGLEQSVKNAVAAGIPVITINSGIDKWKEFGAMTHIGQSEEIAGNAVGARLKTAGWKNALCVIQEAGNVGLEERCKAVTATMGGKVTNLQVDGTDDNAVQATITSKLQADKTIDGVLTLGGQYAIDAVSAVGEAGSSAKVATFDLSADVIKNIQDGKIEFAVDQQPFVQGYAAVTALYLKSINGNDFGGGQPVYSGPAFITKENADAVGKFAAKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY72</accession>
    <name>A0A010ZY72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851772.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3264"/>
    <dbReference type="HOGENOM" id="CLU_090389_10_0_11"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15111" checksum="EE186D341CC5EA5E" modified="2014-06-11" version="1">MIECPNCGRKNRVPAAAEGSPRCGNCHQPLPWIAEAGDDDFTDVAERGKLPVLVDMWATWCGPCRQVSPALEQVARDLAGRVKLVKVDVDKAPKVSERFTIQAVPTLILLRDGTVIARRAGAAPASALRSWLDDALRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYH1</accession>
    <name>A0A010ZYH1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like enzyme, predicted cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3356"/>
    <dbReference type="HOGENOM" id="CLU_012121_1_0_11"/>
    <dbReference type="OrthoDB" id="224125at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="413"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="703" mass="73210" checksum="859C13813F3168BA" modified="2014-06-11" version="1">MVAAGAIFGAVFELADVVVPLVLAVVVPLGAIAIALLRLGRPLGGGSHMALVAAGLAVFAVAVSSSPRHLVAELTGGWIGLFAITLPAPARPDLVAVPFVLLWVGTTLAADLAVRSRSVLLPMVPAAALLTVGLAVALPAPAAQDALATVLPGALVLAAAFACAIVSNSDAGRRTAASVQTVALLLVATVAGVAGTHLEPADPRSVLPLPVAVRPDVNPLDRVSAWLVRPNDVLFTAAAAAGARCWRLTTLSRFDGLNWTAGTTSYTPAGLGVPPSRERTEGPVSIAQRVTIAGLGGTFLPALDRPVRLRSGVDAVDTETGDLLSIAPVERGRTYALVSVPLIDPTDTRPASGPTDALSLPAGLPDVLDNAVEASPGTSAYARIVAMQKLLRDDYRNDPLAESGHTYGDVRRFLTRRSGTTEQFAVTLALAARRLGVPSRIVVGFCPSGRSTVLARDVSVWTEVHLAGGWAGLQPAGPARPARKARVEAPAEVPLPTAAPPPAARPDALAPSSVPQVVNPRLRSAPTPTRPIGVWATAALLILAAAYVTAAQVVPRLRRRTRRRLLSPRGRTAGAWEDLIETLAGDRIDPRIVSSSESVLVAASELSTAAIGEVRPLAALADAARYSRIGPTETDAQSAWWFADRARRRLSRARAIPTRLVIALSPRRIWPQPPIAHGRSAGFFRRHGVKGLRPSGSPGTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYK9</accession>
    <name>A0A010ZYK9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional activator of the SARP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3386"/>
    <dbReference type="HOGENOM" id="CLU_004665_6_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="683" mass="72833" checksum="17CE327DEC6AFF11" modified="2014-06-11" version="1">MNRLPIRGTDVSASVSTLRTATGPRAAADADLRLQILGPLRIWRNGVELDAGPPQQAYLLALLLSRDGRPISTNDLIDLIWDDKAPASALNVIHKYVGLLRRLLEPALPAREMGSYLVRQGNGYLFTARPGTLDLTSFRRLTKAAKDEHAAGRPDDALDRYVDALRLWSGSTADALARESAATGLHTALDGEFHEACCAAADLAVALNQSSRVLPSLRLAARMAPLHEHVQAGLARALAADGQQAEALAVFRATRERLAEELGIDPGPALQEAQRKVLSQTGASAPDHEPLDTPVPGPDAQPAQLPPALPTFVGRGRELTFLADLLSEVRTSPLIVAMDGMGGVGKSALATRFAHQVADRFTDGQLYLDLRGDCADEDDLSAGDALRSLLSSLDVPEGNIPATLDARTGAYRSLTARKRILVVLDNARDVAQVRPLLPNSTGCLVLVTSRTPLVGLAVHDGAHLLHVDLPDLPSARSLLRRRLERSRHLSAAELAAQATTLDEIIARCGRLPLALASVAGWLSSRPRRSLATVANELRDGYERPTSFSGGSPLSDLLSAFEWSYRRLSPEAARLLRLFPLTLSAGATAGACASLCGTTPAAVRASLRELTLATLLEEDDRGVYSAHVLVRAYGHEVSLATDSTPDRAAAVTRLSQYYARGDSHTAGLLEAPPVRSELPPPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZM1</accession>
    <name>A0A010ZZM1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570624.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3839"/>
    <dbReference type="HOGENOM" id="CLU_2034176_0_0_11"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="12766" checksum="FB320C2BB4867CD6" modified="2014-06-11" version="1">MVATQEVARRSGPPEATLRYYERIGLIAPVPRDESSGHRRYDPDTVRTIEAPACLRTAGMGIDALPAYIRSKAIAERAAWDHAAAVGADLAVSRSPGSSGAGSRSGPTGSRPQKPPGRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A000</accession>
    <name>A0A011A000_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase-like glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852731.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3961"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_11"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="588"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="748" mass="79249" checksum="2A6F11E29268EF29" modified="2014-06-11" version="1">MTNRLDVPAVLTALTLEEKASLLDGSDFWHTQPVERLGVPAIMVTDGPHGLRKQAQESDHLGLTASVPATCFPPAAGLASTWDTGLLHRVGSALAAECRASGVSVLLGPGVNMKRTPLCGRNFEYFSEDPLLAGELAVALVDGIQENDVGTSLKHFAANNQETDRMTVSADVDERTLREIYLPAFERVVTRAQPWTVMCSYNRINGVYASEDPWLLTDVLRGDWGFDGLVVSDWGAVNAREAAVAAGLDLEMPSSGGGGTRRILDAVAAGQLSEEDVDRAVTRVLTLVDRSLPALAEGGSFDVDAHHALAREAAVASAVLLKNEGGLLPLDPSAGGAIAVIGEFARSPRFQGAGSSQVNPTRVDSALDALRAALEGRREVTFAAGFVVESESADPALIAEAVRAAAAAEVAVVFLGLPPSYESEGYDRAHMNLPAHQLELLRAVAGANPNVVVVLSNGSVVSVADWQDDARALLEGWLLGQAGGSATADLLLGAANPSGRLAETIPVRYEDNPALGAFPGEHGHVRYGEGLLIGYRWYDAHRLPVAYPFGHGLSYTTFAYDDLSVTAEGDTVEVRLTVTNTGGHAGRETVQVYVTDPEATVYRPDQELRAFATVTLEPGLSAPVSLTLDRRAFAFWHVAAGDWVVEGGVFGVRVGASSRDIRGEATVELKGDAITPPVTTESTVDAWLAHPSGGEWLRGALGDHGFGALLFDERNGQMLRAIPLQRLSRFPGFPITEADVEAAVTRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAT7</accession>
    <name>A0A011AAT7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205128_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="67" mass="8036" checksum="E54BD50BDCA53FE0" modified="2014-06-11" version="1">MNARILGMVDLMSGGQDIERLDPERRRRRIQLLAELAEARALRNRVAPRRARHERQRDFITNRRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACN3</accession>
    <name>A0A011ACN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide ABC transporter membrane protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848563.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.821"/>
    <dbReference type="HOGENOM" id="CLU_028880_4_3_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="354" mass="36635" checksum="72C3BC0595227778" modified="2014-06-11" version="1">MSSTQSRAEQPSPAPVEKSSTIVSFREAVVRYGFVAVTVLLVAYFLISEPNFRTSSNLWGLLVYAAPVGIAGLGVTIAMTVGGLDLSVGSTAGFAVSLAAWTMVIGNQVGGVAIVVVLIAGGVIGLINAALIVWARIPDLLATLTTMFAIMGLKLVLVDGKSISSRMTLDDGSTAPGRFTDGFLYLAQGKIGPVPFPAILLIVISVLVWFLLERTRWGRLLYAVGANPEASRLAGVRVGLYRSAAYVAAGVLASVAGLLLAARIGQGDVSAGNSLLLDAVAVALVGTSVLGRNVPNAWGTVLGALLVTVMVVGFSMKGLPYYVQDVAKGAVLLVALLFSYTLSTRRATLPGQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADM0</accession>
    <name>A0A011ADM0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1197"/>
    <dbReference type="HOGENOM" id="CLU_055261_9_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="150" mass="16899" checksum="D39F3C18D3F4C13C" modified="2014-06-11" version="1">MSTKIHLATEGGQRPLSLLITAGQAGDAPQFQPVIDAIRVAGRAGRPRTRPARVLADKAYGSRANRVYLRRRGIRATIPEQVDRLAHRRRRGSAGGRPPAFHAETYKQRHAVECGINRLKRYRAIATRYDKLAVRYLTTLHIAAINEWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFZ8</accession>
    <name>A0A011AFZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheY-like receiver domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850079.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2011"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_11"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="12962" checksum="2A68343A488166C3" modified="2014-06-11" version="1">MKILIADDSRVMRQIVTRTLRQAGYDGHDLVEAEDGAELVAKANADSFDLVLSDWNMPNLTGIEALRALRAGGNNTPFGFVTSEGTQEMRDTAAAGGALFLIAKPFTAEMFKEQLDSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG39</accession>
    <name>A0A011AG39_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar hook-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2051"/>
    <dbReference type="HOGENOM" id="CLU_024437_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="4">
        <location>
            <begin position="211"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="295" mass="31789" checksum="072D4C108AAFD7D1" modified="2014-06-11" version="1">MVIRVTERSLSMNAMRGLQANQGRLSKTEEQLTSGKLISKPSDSPTGTMTAMLLRSDMRTQEQYARNAADGKNWLNTIDSTLGATHDNGLRVRDLMLQGMSAGAGGSDTARAGIAAEIDQIRDAMIGLANTKYIDRPIFGGTTEGPSAYDKDGTYLGDSGAVTRTIAEGTKLRVDAGGEEVFGTGDNQVFKVLADISEHLKSDPSQLSDDLDRLDTALTTIRTAQASVGARSNRVDSMQQTANDRHLELQTQLTEVEDIDLPKTITDMTLQQTAYQAALGATAKVIQPSLMDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGA1</accession>
    <name>A0A011AGA1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850197.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110118_0_0_11"/>
    <dbReference type="OrthoDB" id="1666264at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="20626" checksum="CCA869515B661938" modified="2014-06-11" version="1">MTRRPGDTGITLIEMAISMFVMALFMTGAMTGILALYRTTNLTQSGSEAQQDLTVAFGRLDREVRYASAISAPGLVGADSYVEFLTTWSGTPTCTQLRLNRATGELQQRTWDQGGALPTPTGWARLASGVTADTPFTVDDVGSPKVYQQLALDMTIGAGGAANRATRGYRVAFTAQNSSSVDTRTTCAEGRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGR3</accession>
    <name>A0A011AGR3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2259"/>
    <dbReference type="HOGENOM" id="CLU_456223_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="589" mass="65121" checksum="8B39145E68973721" modified="2014-06-11" version="1">MGRQNQHVVANTEDDLRLLRAYEPVLRFTRGEYFFPISVEHYVAQAGLWRTEAGVGQVEEIPAGGLTLAKLADAGGAEQGLRLSLSGIGGNGKGLDVSHIPLRERPPHLARASRLASVGLTARLIDTANRASLLFRGSVPGGSAARSFLLQREHLRPDLPTYYGRVFRDDPWIVCQYWFFYSFNNWRSAFGGVNEHEGDWEQVTVYLDGTSSDELPPPRWVVFAAHDEVGDDLRRRWDDPDLSLIDGHPVVFAGAGSHSGAYLPGDYLITVRPPRLGGVVDALRWTSRHVVPWSLKDRHGVGIPYVDYARGDGRAIGPGQPEWWRPVLIDDDTDWVRNYRGLWGRDTRDRLGGERGPAGPRYSRDGSVRASWGDPVGWAGLAKVAPSPASERELVEVRARRNADRVAALDREIAELRQELSVDAAGLPVAAPEVTALAGREKKLLGLRMERIRLADEQVHIDAAPAQHPHAHLRHRRMPIEPMFGLRARFSSWWAVLSTPLMLLAVAAVSTPLIRRGPDAALVLLLVLVAVEGLVKKKLLAVLLRLLVAVVAVAVLAVLWFEGRYVVTFVFLGAALLVLSVNVREALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHP0</accession>
    <name>A0A011AHP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411459_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="667" mass="72154" checksum="D77B963FA5470A66" modified="2014-06-11" version="1">MNPDNPPRDVAPPPSVPTEPQNAVPAEPATPPERVTSAATSRGFGPLEYAVKGTNPIAACLGFLIFAAVVFGVAWVLGWLARITELRIFAYVMILVILGGLFVVGYAFFQLIDGYRATYVYRGGLVWTHNRRVETAAWAEVDRLVTTAVAGHDPHGGRLVTLDGREATLEFGAGGEGFRDRILAALTEWHRPVDFSVADTPLPEEQKVNKRIAVACGVLGVPGGLFLSFPFFLVGVPIGFALAASYGTVALIVAGLAFFVPKLKVPAGVFFGLAGLILIIEANRRLETNFVLVTTAVIALEAAVVVAWRAVWRRLPAPRRLGGRQSLARQYGWRYEDTAQVPVAGLRTMSKLIGVPTGARTVTGEGVLVATAHGVECTVYDRVRRRPLMTDPIQTVWSVPLPVPVPPVTLTELALPGISLDWRGDVRISEPVPPTRGARILGRAVDAIPVAEHPEWWIEDRYLMVAEYGVTSTKTITGRIDYLTRLATSTPWTELADPAVWQPVEPTRWDDDAVFSPPVLEALRVADEERVVTLHTGEVLAVLARVDPQPGWAQLWQRTGTPAGAGLKESVDPRDYDRTPTPAYRGGTLLTPELALALTTADRIRTHYGYPQITTGVFALSLLAHRGTGATETLLAPGRLTHPQLLDVVRSTLIGGPLPGLEALVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIH2</accession>
    <name>A0A011AIH2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851233.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2873"/>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="489" mass="49171" checksum="29949A822DAA5DC0" modified="2014-06-11" version="1">MSMTTMVTPRAAGRREWAALAVVTLAVVVLAIDATVLSLAVPALTADLAPSATALLWIGDAYSFALAGLLVTMGTLADRIGRKRLLLIGATGFALASLLAAFAPAAGWLIAGRALLGVAGATLMPSTLSIIRTLFADARQRTTAIAVWSAAAGGGAALGPVVGGVLLDHFWWGSVFLINVPVMVLLIGFGAVLLPESRDPSPGPFDLGGALMSLVAIVALVYAVKHTVSDGLSAVALISAGVGLAVGYAFVRRQRRSASPLIDVRLFARPAFAGAVGASLLAVFAFSGLLFFFSQYLQLVRGYSPSAAGVRELPATVASIAVVAVAGWLVVRCGRGRVIGGGLLLAGAGFVGLALAEGASRYLWLGLALVLVGLGVGLAFTLTTDAVLSAVPADRAGSASAVAETAYELGVALGIAVLGSAQTVLYRNALPADAGAAARDSLAAAAAAGEPLAGAREAFVAAMQTTSVIAAVLLAVAAAIAWRVIPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIT8</accession>
    <name>A0A011AIT8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570236.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3015"/>
    <dbReference type="HOGENOM" id="CLU_001265_61_1_11"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="397" mass="40607" checksum="AF2B3C60EAA0C58C" modified="2014-06-11" version="1">MNHRAALAALGASTFVYVTAETIPIGLLPEMARDLNVAEASIGLLVTSYAVVAGLTSIPLTAVTMRLPRRALIAGTVAAFVLSQLAAALAPTFLLVVVARLLCALAHGVFWATIAPIAARLVPPGQGGRAIALVFLGNSLAIVLGVPLGTALGQWLGWRVVLAVLAVIGAGCVAALSISLPALAGDVPTPLGRRLRDSVLVLRNRSLFAICATTAVLMIGLFAAYTYLAPLVRRDAGLEGTALSALLLGFGAAGLFGNWIIGRWVDRSPGPLLTTLIAVMVLALVTLAPVLGVAPTVVAVLAWGAAMTATPIILQAAVLRVAPEAGDAASAVYVVAFQIGIGGGSLLGERFVSAGRLGWLPLFAALLAVGAWVIVRTSRTAFPARLPAETREPVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJT0</accession>
    <name>A0A011AJT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIR-like domain-containing protein (DUF1863)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851914.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3360"/>
    <dbReference type="HOGENOM" id="CLU_313692_0_0_11"/>
    <dbReference type="OrthoDB" id="796631at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="933" mass="99938" checksum="7EBCE0F8737F917E" modified="2014-06-11" version="1">MSRSDRWYDLFISYNHGADSTTAEALQTDLQRFARPWWALRSLRVFRDQTDMAAGVELDDTAQAALSRSDWFLLLASPESANSRWVRHEVQWWLRNRDPSRLLVAWTSGTINWVGRDFAPSSTALPRDLYGVFTRERVLVDLSTTPIVDGRPRFDRQRLAMILAPVRERPMASLLDDDRKRARQRVASFTAMAVAVVLAATATGFIWHNRRTTLAAERIATEAQRLSAAAQAQLPTRLDLAGLLAVEAYRLRPGDPRIQSTLFQVISASRSLRRFLPTGAEVSAVAGSADGSVAVAGLRDGRLLAWDAAGNRIGATDTGDRQISQVVVANDGKTVVAVAGRDVVVWHPQGASQQRIRGSSAVGAVGLSASQRRVAVAWVVSDTNTVLTINDAATGKEIRRGPINGFTLRRLRFVDDDTVRACGGFRRVVTYGGTNLSQIAAYTPEMLFPWVSRLGQESYSAGCEFHGFSINGSVTVTATAATKSAETAHADTGVADELATAVSSDGKLVAVPSADGIHVAGIGEQGAAPYGLTASSELLSGVPGASALEFYGGSRRLISAFGTTVVLWDLEQPGRLAQTTAGFSFSWNRRQSMSAPDVAVSDNGRFAAISGEDKDVLVGSRTTLVDLTTGRAVDSTTALARPDWVSSNGHLVLGVDTEYDPALWRPGGAVTTAGAWERPAGSAFPFGAMQADSSERSLTVLGPRGQIEERRVDGTRIRVWRNGSNESSSYDAAAVAADRSSVAQVVDGRIQWTALRSPLSTITLTGPEPDSLWFTAGGDLAASRRDGSLIIYSRRTGQAVRTLPVGPAQYTIAGGRALDRGGRWFARVTTSGGVEIVDADSGYLLGGFPLPMRGEPGKHSPASAQRTTVVSRPGTSELLTLSADGYLTRWNLARQSWSAIVCRVAGRQLTSAEWTTVTGHDVPAEGLACPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKI2</accession>
    <name>A0A011AKI2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_3669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852302.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3632"/>
    <dbReference type="HOGENOM" id="CLU_039483_0_1_11"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG82481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="378" mass="38352" checksum="D9135C2EFF9AFA0F" modified="2014-06-11" version="1">MRPVLLIVGKDLRERLRDRSLFLFAFVVPLLLAFVYDLVLGKASDPDPFRYAVVDLDGGPVAAAFADDVLGALVDDDVVTVRRVATTDAARTLARDGDIDAAFVLPAGFSARVPTRDPAGIDVIGNVDAPTGTQVATAIADAYAGQLNAVRVTVAAGGDPRVAEQAAPLTVVGGPASRKVLDQTTYMAAAMAILFLFFTVQAGLSSVIDERSAGTLRRILALPVPRWTVLAAKAVTSIVIGVVGMGVLVVASSLLMGADWGDPVGVALLVVGGVLAATGVTAAVVATARTAEQAGSRQAVVAILFGLLGGVFFPVGQLGGAVTTLSLVTPHAWFLRGLGELAGGGGATAALPSAGVLTVFGVVTGAIALVGLRREVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKS4</accession>
    <name>A0A011AKS4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570595.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3730"/>
    <dbReference type="HOGENOM" id="CLU_013754_0_0_11"/>
    <dbReference type="OrthoDB" id="952734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="744" mass="78547" checksum="ADF3CE6F1ADD0FE6" modified="2014-06-11" version="1">MIPSILTSYTNQLSYFPGDTIRLYVSSPADDRASITLVRLDAALDSPGKEAQTTEIPWSEATTRPVGGQDGHFGGFLTGTLVTPPATRFTVGAFVRFDGEVRPVAQSIVAVGDDQHSVTLGVEDGRALLTTGDPAGAVRCAEPLQPNAWYLVAGTVDGDRAEVHAIAMDVGARSTSTTGSLTPSGALGRGVVVAGAFPIVTHGTGIAAHGRAAASLTAAVSWPFVASTAVGAEQLRTLAERRSLDATTIGAELLGAWDLYPAHGEDGSAADLAGGAPGRLYNLPTRAVPGPNWQRLTTRFTEAPDEYSAAHFHETDVVDAGWSETFSGALPADLPSGAYAVRVATGREVDFVPFVVAPAPGSARKPVVVVIPTFTYLSYANESLFEGMDPSVTGHFTIGPNDADLAHVGNRTFGLSQYDTHPDGHGVVYSSAARPIVNTRHDYRMWLSDSGRGFSAEMYLLEWLTSVGIEFDVITDFELHTLGADYLGGWKAVLTGAHPEYHSGEMLDTLTRYRDTGGHLVYIGGNGFYWVTGVISESPLVVEIRRGFAGITAWKSRPGETSLLSTGLLGGSWRHRGREPQRLVGLGMAAQGWGGSQPYRRTEASYAPEVAWIFDGVDEDPIGAYGRVMGGAAGDELDRADPTLGTPANAVVLASSRDHGRTYQRDASEVAFILDGQHGGDVDPEVHSDVVYFETPGGGAVFAAGSIAYSGALLENGSQNGISRMTENVVRRFAHLDAAEGNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL24</accession>
    <name>A0A011AL24_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802899_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459515" evidence="2">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="14644" checksum="D8D3D43B91039CE1" modified="2014-06-11" version="1">MRRLALSVLPLVVGAVVAGALAAPAQAVSPVRAAPAEKAPEHRKAPEVRKPETRKPVKVIRFTLTGTLTATTSTSITLTVKGPKRERGTSVTVPVAGTARIALDDEPATLDALPAGAHVVVSGTATTATRTATRVHAETGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFK3</accession>
    <name>A0A010YFK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135004_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="13015" checksum="4A7174CE0F2FAC3D" modified="2014-06-11" version="1">MAAAVLVVATVTITRDLVGAILGLLVAGGLGVSGLRDLLVPVRLEADGEGVTVSAGLTGRRRYPWAVVERIRVDERRRLLGRSTMLEIDVDDDLYFMSRYELGVHPAEVAEELATLRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGI4</accession>
    <name>A0A010YGI4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847939.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107522_0_0_11"/>
    <dbReference type="OrthoDB" id="1764965at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="149" mass="15534" checksum="B4D6861EBD078ABA" modified="2014-06-11" version="1">MATAKTQTTKTGNTVEATGDVKFALPDAKRGLYSAVGAADYAVAQLRAIPRYQGAVVEALRSQVADLQKLPQNLRAQLNDLQGKVNETYGEFADRGEKLVSGIRKDPATQAAVEQTKTAKSQVKAARTSVKKAAAGTGAATEAAGDKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH29</accession>
    <name>A0A010YH29_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.608"/>
    <dbReference type="HOGENOM" id="CLU_016047_18_6_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="32565" checksum="91DFB9833DEDEBC3" modified="2014-06-11" version="1">MPESAPPVEALATPAPLSTSEGGAGGLRRLNVLSLLGVVPFGAYVVVFLIIPTLVVVIGAFGANPDDGGGATLENIKALGSRQVVDAFVFSIALSAASALIGAVLGALLAYAVATAKPDGLLRRIVTSACAVLAQFGGVTLAFAFYATIGLTGFVTVYLADHFDVNIFAGGVWLFELPGLTLVYTYFQIPLMVIVFLPALDGIRPQWREAAESLGGSTWQYWRLVGGPLLAPAFLGSTLLLFANAFSAYATAAALVSQGSPIVPLQIRGALTSEVLLGQENVGKALALGMVVVVAIVMWLYAILQKRTSRWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YH96</accession>
    <name>A0A010YH96_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848414.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.677"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="308" mass="32491" checksum="E9F490C61BE3C758" modified="2014-06-11" version="1">MENTTLTRTGTTAAVRLTGLTKRFGSVTAVDDLSLTIEPGEVVAFLGPNGAGKTTTVDMMLGLARPTAGSVEIYGRAPSVAVAEGRIAAVMQTGGLLKDLTVAETVRMTGSLFGRTRPVNEVLTRAGILDIADRRVGKCSGGQQQRLRFAMALLPDPDLMVLDEPTTGMDVEGRREFWAAIRQDAAQGRTVLFATHYLDEADAYADRIVLVRHGRVVADGTAASIKGLATGRLVRATLPGADPVALAALPGVDQVEVRGDSVLVHASDSDAVARHLLTATGARDLEITSRNLEDAFIALTTDATEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YHV7</accession>
    <name>A0A010YHV7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848646.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_13_0_11"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="68" mass="7816" checksum="6BB8DADAE1239B8D" modified="2014-06-11" version="1">MNASHPARPRRYLTVDEVCEELAVPRSTFYQWRATRKAPPCIKLPNGALRIRRADLDRWLDAHEGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJZ3</accession>
    <name>A0A010YJZ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849509.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1621"/>
    <dbReference type="HOGENOM" id="CLU_069543_0_1_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="252" mass="27097" checksum="39B9A43A90119574" modified="2014-06-11" version="1">MPSDRSSAGDPARTLALLWREPTQPSGRGPKPTLSVDRVLAVGLAIADAEGLDAVTMRRVATELAVAPMTLYTYVPGKAELLDLMLDHVYATMPRTPPGDGWRARVTAVASDNRDMYARHPWVATVSTSRPVLGPGLMAKYDHELSAFEGLGLDDVTIDAALTYVLGFVETCARAAADVRAARYESAMSDGEWWAANQPLLERVFDASRYPLAARVGSAAGAAHDGAYDPAHAYEFGLERVLDGLARLIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLA8</accession>
    <name>A0A010YLA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569995.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2079"/>
    <dbReference type="HOGENOM" id="CLU_062618_7_3_11"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="29129" checksum="5CAE652855081137" modified="2014-06-11" version="1">MEPGRGDGSDVVPKSVLARGLRLLDAFGPDDVDLSLSELSERTGLPKPTAYRLLNELVTWGGLERTTRGYRLGMSLFVLGQRVPRHRELREAALPYLEDLYEATHENIHLTVPAGNDTLFLEKVSGRRSTPIVSRVGGRLPAHCTATGKVFLAYGSPDRLRQVVEAGLTRLTPRTIVMPGLLRQELARTLERGYGVNREEAEVGVSAVGAPVFDHQRSVIAAISITGWAQHLDLERLAPAVRTAALALSRELARDTANGTLRWSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMA0</accession>
    <name>A0A010YMA0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">CryarDRAFT_2451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850628.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2414"/>
    <dbReference type="HOGENOM" id="CLU_001715_1_1_11"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG81340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="198" mass="21535" checksum="D06745A7D38DF776" modified="2014-06-11" version="1">MDAEIPGLPSRAADAARLTVLSGPSGVGKGSVVAEIRRHHPSVWLSVSVTTRAPRPGEEHGKQYYFVSRDEYDAMVAAGELLEHAEFAGNGYGTPRRAVEERLAAGRPALLEIELQGARQVRAAMPEAQFVFLAPPSWDELVRRLVGRGTEDEDTIRRRLDAAVVELAAEKEFDVTIVNDNVGQAATELVELLSVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YMZ6</accession>
    <name>A0A010YMZ6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-lysine 6-transaminase</fullName>
            <ecNumber evidence="4">2.6.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysine 6-aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21200"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="EC" id="2.6.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.36" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570119.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2659"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_11"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045484">
        <property type="term" value="F:L-lysine 6-transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017657">
        <property type="entry name" value="L-lysine_6-transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03251">
        <property type="entry name" value="LAT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="442" mass="48234" checksum="54797AB898E287E3" modified="2014-06-11" version="1">MTQIVDAPGTVRAGNVHAVIAKHLLADGFDFVLDLEASQGSTLVDARDGHEYLDLFTFFASSALGMNHPALADPAFRAELLRAATNKPSNSDVYTVEMAQFVDTFAEVLGDERLPHLFFIEGGGLAVENALKVAFDWKSRWNEAHGHDPALGTRILHLEHAFHGRTGYTMSLTNTDPNKVARFPKFDWPRIPAPYTREDADMDALEASALLAARAAFEAHPHDIAAAIMEPIQGEGGDHHFRPSFVRALRDLCHEFDALFILDEVQTGVGLTGTTWAFQQLDVVPDIVAFGKKTQVCGIMAGGRVDEVADNVFAVSSRLNSTWGGNLTDMVRARRILEVIRDEKLVARSATLGEHLYESLRTLGEKHPGVSNVRGRGLMCAFTLTDTALRDALLNGLHQDESVLMLGCGSRSVRFRPALTISEADLDNGVAAIDRVLSRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YN32</accession>
    <name>A0A010YN32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851001.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2690"/>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_11"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458866" evidence="1">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="416" mass="45208" checksum="0E92BD28FC289545" modified="2014-06-11" version="1">MSWFRRTGALVGLVAVMATAACGGDSDTNDDPNAKATISYAVWDKNQVPAMQKLAADFTKTHPNITVNVQLSPWETYWTKMKAAATGGAAPDVFWMNGPNFQLYATNDVLLPLDGVDTGNYPKSLVDLYTVEGKTYGVPKDFDTVGLWYNKELFDAAKVKYPDDTWTWDTFKAAAAKLTNKAKGQYAIGSTLTSAQEYQYNTIYQAGGTVLSDDATKSGYADPATIEGLKFWTDLIKAGQSPSLKTLTDTQAINLFESGKIAMYYGGSWNAAEFSTNEYTKTRADVAVLPQGKKRATIIHGLANVVAAKTKSPAAAKEFVKFLGSKEAAELLAQNGVIPAFNGTQDAWVKSHPEFNLQAFLDEVEYSVPYPVSRNTAAWQELETKYLTPAWNGTTDVAAASKELATAMDDALAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP23</accession>
    <name>A0A010YP23_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570234.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_2_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="367" mass="36047" checksum="BD9AD970C714994A" modified="2014-06-11" version="1">MTTRSAQLLRIVHARPGVTRAEAARLIGIGTGAATELVGRLGAAGLVREQPAAPSGARGRPTTALGPHPEGPLVAAVSITHEAWQASAVELGGRVVSSAVGAHRGGDPSVVLTAVRGAIEALGPRVRGVGVAVTGPVSRDQRVEAFPLGWHALDLSPLRAGAGVFVVGNDAMLAGAAESSRGAASGAAVALHVRVAAGIGGAIVADGRVVTGAIGAAGEFGHLPFGDPGRECSCGASGCWGNEVDGSALARLLGVAPPPDPIAYAHRVIAGAAESPDAEAAVRVVAGALGRGVAGLVNGLDPDLVTVGGLGVGLLAAAPDAVQDAYLAGLMRFRRASAPPVVAATFGDDGPMIGAAEEAWNAVLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YP42</accession>
    <name>A0A010YP42_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851466.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3034"/>
    <dbReference type="HOGENOM" id="CLU_120069_2_0_11"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13540" checksum="5222CF3029A98E73" modified="2014-06-11" version="1">MDDRFTVLADVERPDFPADAGVMTALVEVAPGSGGSPPHRHSGPVFGYVLEGEVIFELEGEAPRVLRAGDTFSEPGGDVVHYRAANNRPDAWARFLAVMVCAPGVEMLTYLTADEIAARRHLRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPL8</accession>
    <name>A0A010YPL8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851732.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3234"/>
    <dbReference type="HOGENOM" id="CLU_222687_0_0_11"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1631"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3121"/>
            <end position="3196"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4618"/>
            <end position="4693"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="6072"/>
            <end position="6147"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="7531"/>
            <end position="7606"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="9016"/>
            <end position="9091"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1666"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="3156"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="4653"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="6107"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="7566"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="9051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="9166" mass="952729" checksum="9B3DE6ED7EC76EBE" modified="2014-06-11" version="1">[encoded data, 9166 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ62</accession>
    <name>A0A010YQ62_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852021.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570761_0_0_11"/>
    <dbReference type="OrthoDB" id="1742133at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="478" mass="50957" checksum="B4F0AE61B402A58A" modified="2014-06-11" version="1">MDERDDLATLLRTRPPRPLPQADRQRIALMDEMRATRSAARARRWTVGRLRVPAPMLAAGALAATLAVAAAGTTVIGLNNEESVAPGTGDGTTLSAATLADLLRRVDAAADRQPPTVVGATQFLYVRSLDNNNFQPGDPPQNKQEWHSADGTRYGVLDGKATSVDVYESGEQPPAGTPALDAAVLYPDPSRLSGLTNVEPAALLAAINRLSAPGAPAAERAFDRVQTMLDTGGLAFPRVRALLYHVAALIPGVRYDPDGADLLGRRGAVLSLRIDRSSFDLVVDPDTGELLGRRGTAYERYAVVDRIGERPEGAPVGTTPPERPGDRTVRGLDYADETFVVPVDEHFGTASNSDASSLPTLAFQGGVATRRDAEGRTLRYEMVSGRPVAFANLLGRVEGPVLLLRVHTAGLPDAQTAWAVLFLDFSHAEGGPTKLVTWIDPGPDAVSVEASGTTVTVTPAGGVRQRYHWDGDRFTRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQK3</accession>
    <name>A0A010YQK3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852281.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1419362_0_0_11"/>
    <dbReference type="OrthoDB" id="2054737at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="191" mass="20061" checksum="D7DAB1B61E27597C" modified="2014-06-11" version="1">MAGHPLIGRYLRQLSDRLPADTVDELADGLHETWTHFLERGDDAEAAARAAIAEFGTPAQVVDAFVADAPGRRTARALLATGPLVGACWAACLIEARAWTWPIPTGVRAGYAAAVVTVVICLLIAASSRHGYRRTRLGDVGAAALVPLDLVMIAAVALAGSTFVWPVIVAVPASVIRILLITRALPGRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQM6</accession>
    <name>A0A010YQM6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852344.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3661"/>
    <dbReference type="HOGENOM" id="CLU_030671_0_0_11"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="34953" checksum="E56ECE98B4C7C358" modified="2014-06-11" version="1">MCGTNFVDQATADKIAATAAKFRQITESPFGPDDEIGMLNLITPESMRAVLSRADAGHTIDLSVDYFLGMPSFTAAGQPPYQIWMTNTPRGTAVDDGTGFGEQNKLVGYSGDAISMYTHCGTHIDTLNHFGYGTKIWNGFDADQYLGARHWMCAGAEKQPPIIARGVLLDVAALHGVDVLPQSYGIGAKDLADAARAQQVELRPGDVVLIRGGQMTLWDDPQAYITNEAGVNRDGAEFLARSGAALVCSDNLSFEQIPSTEEGNWLPVHTYLFAEAGVPIMEVVDMEALSAEKLYEFCFIGAGIKLRGATAAPMRPLAMPLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRI9</accession>
    <name>A0A010YRI9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-glucose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852769.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3985"/>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_11"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="41063" checksum="D63AD35EDB91B5B9" modified="2014-06-11" version="1">MARPRTLLLVLAGGAGGRLELLTDHRAKPAVPYGGSYRLIDVSLSNAHHSGIDDVWVIEQFHPVSLTDHLANGRPWDLDRTHGGLLTLHPHLGTEREGWHQGTADALWRQAPLIREFDPDHLVVVSADAIYALDYDTVVAAHAEGGGDVTMVTTRRPIEEAGRYGVVETGDGDRITNYVYKPDEPATDLIANEVFVFRPSALLDVLGSLEEDGGDLGDHALPQLVDAGAAREYRFDAYWRDVGTVPAYLESHLELVGDDPAIRLDDPAWPMLTRGGHHGPARLARGAEVADSLLSAGCDVAGSVERSVLSPGVIVEPGASVTDSVLLHGAVVRRGARVRGAIVDTGAEIGAGASLDGTDDVVLVGAGARVAKDEEVTGGGRVARENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRQ9</accession>
    <name>A0A010YRQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852965.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4082"/>
    <dbReference type="HOGENOM" id="CLU_1710213_0_0_11"/>
    <dbReference type="OrthoDB" id="1471103at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027590">
        <property type="entry name" value="PQQ_MSMEG_3727"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04339">
        <property type="entry name" value="PQQ_MSMEG_3727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="16607" checksum="AF6980BFF3D57ACF" modified="2014-06-11" version="1">MTIAQDRDLLLDKLGLNAQNSAALGKVLNTGNIGQATERADGTMEATIRIKPDEICWDPSILVLPHGGDLELTLINDDLNTHCALLPSNGDRKFIWLVNHSKGLARLNLDGPGYYWFSSPTGNDEGRGLTGTIVVLGDVPPEARLDRPDQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRZ8</accession>
    <name>A0A010YRZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxyacid dehydrogenase, FMN-dependent L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035853128.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4171"/>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_11"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="423" mass="45991" checksum="990305C024C47FBC" modified="2014-06-11" version="1">MVRRQVPKPAEIFELLQLKKPQLNGRTRRLDSALTIADLRRIAQRRTPRAAFDYTDGAAEAELSLRRARQAFLDVEFHPSVLADVANVDTSTTVFGGPSAMPFGIAPTGFTRLMHTEGETAGAAAAGAAGIPFTLSTLGTTSIEDVKAANPTGRNWFQLYVMRQREISYGLVERAAAAGFDTLFFTVDTPVAGARLRDKRNGFSIPPQLSLRTVANAIPRPWWWYDFLTTPKLEFASLSSTGGTVGELLDAAMDPTISYEDLKIIRDMWPGKLAVKGVQTLEDAQKLTDYGVDGILLSNHGGRQLDRAPIPFHLLPDVTREVGHHVEISVDTGIMNGADIVACLALGAKFTLIGRAYLYGLMAAGRPGVDKTIDILSTEIIRTMKLLGAHSIEELTPRHVTQLARLAPRSAAEVRSPSGPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWV0</accession>
    <name>A0A010YWV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569684.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.665"/>
    <dbReference type="HOGENOM" id="CLU_000445_107_12_11"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033462">
        <property type="entry name" value="Cache_3-Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17201">
        <property type="entry name" value="Cache_3-Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="399"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="463"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="714" mass="74152" checksum="3A166475DC8F4A52" modified="2014-06-11" version="1">MPSFVRAFSGLQMKHRLLALGVGGVVTTAIVLVIVGAWQTNAFSEHARENVSALTTADLDHVAQGVDRLTTTAGSGIQAQVNRGMTVALAELGQRGGVRLAPATASWTATNQTTQAKRSVTLPRLLVGGTWLGQNRNLSVRTPLVDDIYGMVGGTVTVFQRMNSAGDLLRVATNVKAKTGNRAIGTFIPATAADGTPNAVASAIKSGKPYRGVAKVVDTWQVSAYNPLKNSAGQVIGAIYVGTPQSEATASLREAIAATKVGENGGVTVYSTLTADKGRVIAATDPDRVGADALEDKDADGNAYVQDIIERATALEPNQTTNVFYRLPGISTDTPARTQVAVSYYAAYGWAIEVASYLPDHAAAIDEINSGRSTMLWAFVIAGLLLALVGGVVAWVWARSISARMERLTASIVGLSRRDLTVDVSVDGGDEIGRMGTALRTAITELRGLLSGISGASLEVAGAAERVTVAGSALAGSSTRASEQTGDATQAAAAVSENVQLVSESSEQMGAAIAEITTNAQEAAGVARESVTLSQQAGEVIAKLGESGNRIAEVVKAINGIAEQTNLLALNATIEAARAGESGKGFAVVASEVKDLAQETARATEDVTARVEEIAADTRLAVTAIEGISESIARVNDFQTAIAAAVEEQTAATGEMSRNVNVAADRSNEIARNLGEVLNTVDTTRNAVQDSRQAAEELNATARHLTELVARFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYR4</accession>
    <name>A0A010YYR4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="452" mass="45759" checksum="B8F72434BD0F729C" modified="2014-06-11" version="1">MATTSRAGTATTPLGREPWPPRARLIVFLLALYVMLAFGDKAILGLVGPRMMADLGLTNAEFGLVGSSFSLLFCVTAIGIGLLGNRVSPRWLLAGLAIVWAVAQLPVLLPVVGFAGLVGTRILLGAGEGPAVPLASHTAFTWVPIRSRALAATLLAVGGGAGVVVGAPLLMLAIQAYGWRAPFGILGVLGLIWAVGWLAVGGTGPHHYAAPGTTAGDAPSGSRVPPGTAAGAAGESPERVPYRRVFALSTWWGAVLAGFTVFWTLGLALTWLPTYLEEQAGYDPSTVSLLVGLPSIFSIVSILVAGMVADRLLRRGGSRRVAYGVVPAVAMIAGGIALVAMSRLGAGWPLLAAMTIAFSTGPALTPLTNAAIADVCPPAQRSGVLATAHAFATTGNVAAPFASGLVVDLAPTESVGFTAALDLAGVLLLAGAALAATTIRPDAHAARLAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z102</accession>
    <name>A0A010Z102_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850300.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2183"/>
    <dbReference type="HOGENOM" id="CLU_026568_1_0_11"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="438" mass="46523" checksum="EBFDFEE60B721235" modified="2014-06-11" version="1">MRRRWTRPLLVTVLTAVVLLGAGVALGPWHRLAPERAAPATAVRSPTQELDAYVGRVQAHLAAVPGDWQGWAALGLARIQLGRITYDPAHYQAAETALRRSRQVRPQDNAAALTGLGALAAARHDFRAALRYARLAVAADSYSADAYGVLTDANIELGRYPEATAAVQRMLDLRPDTGSFARASYLFELRGDQRRAVELMTRAREVATTLDEITFALTHLGELAFGAGDTDTAAAYFAEGLARVPGQPALLADRAKVSAARGDLTAAISDLRAATATLPTVDHLMTLADTLNAAGQAGAAGQTDDLIRLSARLPAATPATTDIDLILFAADHGDARMAVTRGKALLAARPGIKVETAYAWALHAAGDDRAALHHADRGLRLGTRDAQAHYYRAMIRLALHDRAGARADLSRALSINPHFSLRYGPSARATLADLGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z176</accession>
    <name>A0A010Z176_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072584_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="106"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="23577" checksum="8F7CE70ACA12832A" modified="2014-06-11" version="1">MSYPPDPYGQPQYGQPPYGQPQYGQPQYPYGNQPPPGPAPYGAPSGYGQLPPPKKSSGGVIAIGIGVALLAVCLVCGIAGAIYLANGGGNEARDTAGPGGERTGRLNEPVKDGDLEWTVKSGECGKTAIDYVKAAQQFCVYQVTVKNTGRAPVPRGLGFYEAYDAAGQMYEFNLLASTTATENDPREFAPGATANLSLVFEVATGATPTKILLRDSTGADGVTVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z196</accession>
    <name>A0A010Z196_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2276"/>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="39324" checksum="FA255B16B4E121C1" modified="2014-06-11" version="1">MQLVTRWARDTIRLVGAGLAACLRTFGLALSLVGVGLVFLDATLAATVRAAARRQGRTVSVPRLRARLADPATWRAVGWQAGLGLVLLPAGVAALVLALGGVAGVLAPVLEAVPHPGELSLNGRVIADQRTAWVVCAQGVVLGVAAYGLGRLLVAAEAALASALLRPSVENARIAELTESRAQSVRAAEQELRRIERDLHDGAQAHLVAVALDLGLVEQLVDDERARRLVAEARAGAAAALEGLREIVHGIHPPVLAERGLAGGVQELALAAALPVEVEVELPGRPPAPVESALYFTVAELLTNAARHAGARRASVVLRRDGDAIRLTVRDDGHGGARPRPDGGIAGLRRRLAAFDGQLAVTSPVGGPTIIEVSVPCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1B3</accession>
    <name>A0A010Z1B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850450.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2291"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1020" mass="108754" checksum="7A90652AAC22D217" modified="2014-06-11" version="1">MTALRLAVLGPLRIWRGDVELDPGPRQQVYLLTLLLARAGRPVSATELIELIWDDDPPATALNTVQKYVGSLRRLLDPSLLRRRGNGYVFVAGPETLDLVAFRQLIAEARRSGDLDRYVAALKLWRGPAGEGLDHGPAATAVFAALDAEFFDACVAAAELAGSLGRAERVLQPLLLAALMAPLHEPVQASLVAVLAAAGQQAEALAVYRAVRDRLVGELGIEPGPALRAAHARVLERSPVPTPGRDAPALVGRRGELAVVRDALDAAFADEAGLVLVEGEPGVGKTSLLEAAAAEAERRGAMVVWGHCVEGEGAPSMWPWVQAIGAIVDGRPDAEREKWLAGELGRLLEPRDDVLGEPRGGVLTVPVRSDTGAQFRLFERVLALLAQVAARQPLLLVLDDLQWADVASLQLFGHLAARPPRRTVVVGALRDRAPVPGAELTRVLATASRNPRHRRTRLGPLGPGEVAELVVRETGRPVSAELARRVHERTAGNPFFVRELARLLASSGAAAGLPAGVRDVVVDRMAGLDAVSGELLRIAALIGRDVELGLLARAAGLGVPDCLDRVEPIEALGLLAPVPGDSFALRFPHDLIRESVLRTTPAAIVPRLHLRVADALDREDDVETLAHHLAAAGPLADPGRTAKALVGAGRRAAAKSALATAERQLRSAAGVARAAGRDELELSALSQLIAVVGMRSGYAGSALDELDRAEQLARGLGRERDATDFLYSRCATYSQTLQFERARPLARRLLEDGEASADPIVRGYGVHAWGIHQWDLGNIGEAYRYLRRLDVGGRADRETHRLRHDLLGLSPAILAQVTALHGEVDAAREMFETVAAAAGDDPHAVTLTASFTSTTAMFVGDPAWALSAAERGIAADPGFSFVFYGAYLRMNRWWAHAVTGRDPARAAAEIEALITATVLDPPLTGVSTRFGQLAEAWLAAGEPDHAAAALDRAEDLLTTYGQRYAEGHILLQRARLLQARGAPADAVRAAVERARAVSTQREAHLFARRAAAVQDTGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1K1</accession>
    <name>A0A010Z1K1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin, Ohr subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850571.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2361"/>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_11"/>
    <dbReference type="OrthoDB" id="1984062at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="14319" checksum="0B4E1ACC335249EF" modified="2014-06-11" version="1">MSALYTAIATADGNGRNGRTRTSDGKLDVQLSFPTEMGGSGAGTNPEQLFAAGYAACFSSALGMLAAQRKIDAKDASVTAEVSLNPTDNGGFGLAVTLRVELPESLQGDAGRELVEAAHQVCPYSNATRGNIPVELVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2K3</accession>
    <name>A0A010Z2K3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">CryarDRAFT_2771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851062.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2733"/>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_11"/>
    <dbReference type="OrthoDB" id="918580at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="251" mass="26326" checksum="0A80ED4FFF16C7FA" modified="2014-06-11" version="1">MDIDLNSDLGESFGTWRLGDDAAVLDVVTSANVACGFHAGDPRTLLSTCERAVAAGVVIGAQVGYRDLPGFGRRFIDYESADLVADLLYQLGALEGLARVAGGRVRYVKPHGALYNTIVHHEQQAAAVVEAVTRFDASLPVLGLPGSVFLAAAERAGLRTVAEAFVDRAYTPAGTLVSRREPGAVLHDPDLVAARMVRLVTRGELDAIDGSVVTVRADSLCVHGDSPGAVGMARAVRDALESAGLTVRSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3C7</accession>
    <name>A0A010Z3C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851389.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2997"/>
    <dbReference type="HOGENOM" id="CLU_039613_39_3_11"/>
    <dbReference type="OrthoDB" id="1591366at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="33447" checksum="171173C099DBD0B3" modified="2014-06-11" version="1">MQLDLNLLSALDALLEEGSVAGAAERLRLSSPAVSRTLGRLRRLTGDEILVRTGRTMTPTPYALAIRERVHELVRDAEAVLMPSRTLDLHELDRTFTLQCHDALATALAPMLLTEAASRAPKVRIRLLTEGASDTDDLRHGRVDLEIGADRSDLPEIRSETIGHDRFVLVMSPEHPCAEGEIDQERYAGQTHILVSRRGRLADPADRILSEAGRRRRVVAAVGSSAIALHAVSRGRHLLTVPEAVCRPLIDAFGLVVRPLPVPLPPLPIVFSWHERFDRDPAHAWLRAEVSRALRTTTPGISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3D8</accession>
    <name>A0A010Z3D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851409.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3007"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="34399" checksum="B9A829F1D9BF0227" modified="2014-06-11" version="1">MPKPMSEQVVVITGASTGIGRATALTLAGRGAKVVAAARNEGALASLVADARGDVLAVPTDVSDAAAVHALADAAESRYGRIDTWVNNAAVAMWGRIEDISGDEFDRVMRVNFLGQVHGVHAALPALRRSGGGGIIGVASVESIRAVPLQAPYSASKFALQAFYECLRIELAQEGSPISVSTVLPAAIDTPLYDHGRSKLGARPKPPPPVYAAELVAEAITRAVERPRREIPVGDSALGFYLGQRISPALADGFMAIRRLAKTSQMYGDRADNGVDNLDKALDEPGRVHGSYPGRVLRHSLLTQLAARVPRPGELLTSAVNRLHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3R7</accession>
    <name>A0A010Z3R7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114361_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="27762" checksum="596F13798BFA7491" modified="2014-06-11" version="1">MGARGRRPTSQSGRPGVPWYVAGGWAVDLFPGGQPHEHEDLEIAVPSDGSRQSGMRSTYRFEAIGDGRARPIDDPAFEHTYQTWLRERETGIYRAGRSGRRVAHPGIRAGQANRDAHCDERSRGQHRRRRARRGKRRPSSPVDSASCATAPRWRPAPTRYCRDPGRACAGDAQVRELTGRTRMTSEEIYALVSALGGSRRILIDPDPIDRAQVYRSLNLDLTHHPSRRTVTAEARPEGHVLMSCVRGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4D4</accession>
    <name>A0A010Z4D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570383.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_1_0_11"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="153" mass="17320" checksum="8314699E7F4DCD90" modified="2014-06-11" version="1">MSDEVAIRSLFDSTLTAWNNADAEAYGAAFTEDADYVIFVGTHYRGRRIITDMHSVLWRKFLRGSRLLGHITDVRFVTPDVAVVTSVGRVLKSRFSRRKPDKAQTFVAVRENGEWKFAAFHNTTRRPLLEWISSRSDRRLAPNTPPVPAVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4K0</accession>
    <name>A0A010Z4K0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851958.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3392"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1018" mass="109443" checksum="897B2D3570087F2B" modified="2014-06-11" version="1">MAELPVRSAADGALRLHILGPLRVGRAGVGLDVGPPRQARLLALLLAQAGRPLSTAMLVDLLWGDDAPASAPNVVQRYVGALRRLLEPELPAREPGSYLRRQDSGYLFVPGEGMLDLVAFRQRVEAARAALAEQRPEAALSDYIRALELWEGPAADGLRHGAGATGVFAALDGEFFDACVAAAELSIRLERPQQVLRPLRLASAMDPSCESVNTALHAVLTAAGPPSATADDATVTRESVVGRAAERVTLQRAVSASLDGGTGLVFLEGEPGVGKTRLLEEAALDADRRGVLVLWGRCREGDGAPAMWPWIQIVEGVLDARGSADRDQGPTGELVHLVRQREGDVVEAALPVEGSQFRLFRQVVDLLARTAAPRPVLVLLDDLQWADTASLQLLGYLAEWLPERTVVVGALREHGVLSDPELTRMLSTVSRVSGHRRIHLGPLGPDEVTELVRREIGRDPAPEVARGIYTRTAGNPFFVRELARLLADGGVFTPEALTRGGVPSTVRDVVRDRMDGLGDRTSELLRTASVVGRDVDLRLLAGITRLDVASCLAALEPVHALGLLATVPGDPFSVRFTHDLVRESVARDIPQARAARLHLAVADGLEKVDLGDVFTAERRAHHLWAAGPLADPARTAAALVAAGRRAAARSALVAAEQQLQSAAQLARDADLPEWELAALSQLTAVVGMRTGYRASAFDALERAEQLARTLGREREAADFLFSRRAAYSQAGRLDRSGPLARRLLEQGSDSPDPLVCAYGLLAWGIHQWDVGDVGEAFRYLGRANRTLVEDLAERAERPLRYDLQLMSLGMLAEVTALHGDVDAARALLDGMEIAAGEDSYAITVWTSFAARIAAMAGDPEWALRVAREGIAEDPEFSYRFFGLYLRLARLWALAVTGREPAVAAAEAERLIEAMLLDPPRSNVPTWCGLLAEAWLAADRPAKAAAALDRAEHFLESTGQRYAEALLLLLRARLLRATGGEASSVAERAGALAREREAHLFARRAADFLAGPDAGDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z6J1</accession>
    <name>A0A010Z6J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4100"/>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="45891" checksum="D08F2EE7C0892983" modified="2014-06-11" version="1">MPDVTRPLPAHENTFYFGVVLDFDPYDHRLQDDPYPVYAHLRREAPLYHHAEHDFYVLFRHADVDAALRADGVYSNRMGVTLDASAWNPHAHLVMSFLALDPPEQTRLRRLVSRGFTPRRVAELEPRIQRITEQYLDELDGSFDWIADLAGRVPMDVISEMLGVPESDRAEVRRLADLLVQREDGLRDVPPAGIEASFQLLEYYRDLVAARHRRPADDLTSALIAAESDGDRMTDDEVVAFLFLMVVAGNETTTKLLGNAIYHLRDDTGRVFADPGLIPGWIEETLRYDTSTQLLARYVVADVTLHGVTVPAGSQLLVALGSANRDPAVFTAPDSFDLTRGRDELSKILSFGGGRHFCLGASLARLESAVVLREVVRRLRTVEVDHENCVRFYSSNVRGFAAVPVTAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKE1</accession>
    <name>A0A010ZKE1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569542.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092810_3_0_11"/>
    <dbReference type="OrthoDB" id="1601056at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="14"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="214" mass="23185" checksum="7EAE60B0DE179D65" modified="2014-06-11" version="1">MSARLERAVLAAAAHEYLRVGWPVAPGAWWSPQLQRYRCGRPRCRTSSPHAVDPGVGPSGDRCRATVAECVVTSPTEVDRWWTGHPYALLMPTSTGPGVVDGTQDVIDVIDERLRADGYLAPISSSKVGQAQLFCQQLRPGQELWLAAAGAGVLLHGEDSWVTLPPSTVRTGQVRWLRSPQECGWRLPPAAVVCAALRVALTFRSRPVITGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKL1</accession>
    <name>A0A010ZKL1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035859946.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.204"/>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_11"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="18860" checksum="3DDAE6832D811B44" modified="2014-06-11" version="1">MGSDAELLRSIAAGDATALRLLYERHSGGLFGYLHRLAGDRMVAEEILQDTMLAVWQSAGSFEGRARVTTWLFGIARRQAHNRLRLRAGPAPTETTDRPDASTGPEELAIAAAGGTPVAAAIDRLPGHHRDVIALVFVAGLPLADVADVLGIPVGTVKSRLFHARAAVAAALAAQEVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKM1</accession>
    <name>A0A010ZKM1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">CryarDRAFT_0227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847707.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.214"/>
    <dbReference type="HOGENOM" id="CLU_049966_0_0_11"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG79199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="355" mass="37201" checksum="98685A30DCF91208" modified="2014-06-11" version="1">MSRKPTLAVVGATGAVGTVMLSILSERADVWGEIRLVASKRSAGKRLVVRGEEVEVRLLEPSVFDGVDVAMFDVPDEVSAQWAPIAVSRGAVAVDNSGAFRMDPDVPLVVPEVNGAAAANRPKGIIANPNCTTLTMMDALGALHAKWQLTELVVASYQAASGAGQPGVDRLHDELGVVGGRRDLGVRAGDVRAALAEKLGDQASPFPAPLALNVVPWAGSLKDGGWSSEELKVRNESRKILDIPDLRVSATCVRVPVVTTHSLAVHATFASPVTVDEAHEALAEAPNVVVVDDPAKGEFPTPADTVGADPTFIGRIRQALDFPNTLDLFITGDNLRKGAALNTAQIAELIAAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZL75</accession>
    <name>A0A010ZL75_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725646.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.428"/>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_11"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459140" evidence="1">
        <location>
            <begin position="29"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="424" mass="44582" checksum="EBE3185641EA98BF" modified="2014-06-11" version="1">MSRKRTLATAVVAASLALTAACSGGTNAANESSGGGDALRIASVATDRVGVEALIAEFKKSNPDVEITTSFADTDQYQGTLRTQLASGTAPDVFFAWPGNGNPGSIEVLAPTGYIEDLSDRPWVKDIPDGIKPVTVVKDKTYVVPLTFAGIGALYNKKALADVGGTEPKTWTEMLTLCATAKSKGKALFALGNQTNWVTQLADYALAATLVYGKTPDFAQQMTDGKATFAGSAWKTALDQYLEMNKKGCFSANPLGTSIENAISQVASGKSVGMIHVTSGLNQLQSEAPSGTEFGMFAVPATDNAADTQMPGAAGGSYSVNAKAKNKDLALKFIDFLGTPAAINIYAKETGNLPGIPNDQFQADPALQPLVDAQKAGKTVPFMDQLWPNPKVQNVHFAAIQDMFSGKATPDEVLTRMDEAYKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLL7</accession>
    <name>A0A010ZLL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848300.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.586"/>
    <dbReference type="HOGENOM" id="CLU_029030_0_0_11"/>
    <dbReference type="OrthoDB" id="367541at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="491" mass="54844" checksum="BDD39B2FEB1B4194" modified="2014-06-11" version="1">MGRDVPAVEFTRDDRRRYREKVRQCLDTLAQMLAESRFDFDRPLTGLEIELNLVDNDGLPAMRNAEVLRAIADDQWATEIGQFNLEINMPPRRIAAAGAGELEKEVRDALNAADEKARPLGTQLALIGILPTLRESHVNLGTLSANDRYRLLNEQIFAARGEDLPIRIDGVEQLDTYADSVAPESACTSVQFHLQVSPTTFGAYWNAAQAIAGAQVALGANSPYLFGHRLWAETRIPLFEQATDTRSDELKAQGVRPRVWFGERWITSVFDLFEENSRYFPALLPLCEDEDPEAVLAAGGTPSLPELTLHNGTIWRWNRPVYAVVDGRPHLRVENRVLPGGPTVVDIAANMAFYYGLVRALVDSERPVWSQMSFAAAQENFHAGARDGIHSRQYWPGAGEVPVSELILRHLLPMAAQGLDAWGVSADERDRLLGIVEGRCLAHRTGAEWQVAAVEKYERSGLGRDEALRRMTVDYLARMHSNEPVHTWSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMB5</accession>
    <name>A0A010ZMB5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848560.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.819"/>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="294" mass="30658" checksum="EC4633DEC6EC4092" modified="2014-06-11" version="1">MFFVTGASGGIAGGVVPALVEAGHEVVGLVRSDEGEAKVKAYGAETRRGALDDLDSLRAGAEDADGVVHLAYNHSDFAAAGALERAAIQTFMDVLEGTGKPFLFASGVALHEPGEVLTEDDPSPFSGPEGHRGGGEQLALSYAERGVRAVSLRFPPTVHYTGDHGFVAHLARVARERGASAYVGDGANHWSAVHRDDAATAVVLALEKSAPGAAVHAVAEPGIPTRELAEEIGRQLGVPTESVSPEEALARFGFVGMALATDFQASSTLTRRRLGWEPTGPTLFDDLRAGHYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPP2</accession>
    <name>A0A010ZPP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847683.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.202"/>
    <dbReference type="HOGENOM" id="CLU_1198177_0_0_11"/>
    <dbReference type="OrthoDB" id="1670973at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="231" mass="24103" checksum="D07BA235D4D591DF" modified="2014-06-11" version="1">MKPLTLWQYEVRRAGWSALLGPPIAVAVGIVAALANPMPSDTTTARILLGTLEMAVPLAAGVACASLVGRDPAVELQLTSPTSYRVTLLRRLGVTLGWSAAFAVPTAVALIVTGWWARWPANHGALVGQLTWVAPTLGLSALGFAAGAVFRSPGAAGALVTTLWAIQQFFAGAAQDHRAGRLLYLFATTRGSAPDDWAANRLTLLGASAALITLALVVLGRSERLIGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQ16</accession>
    <name>A0A010ZQ16_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1801"/>
    <dbReference type="HOGENOM" id="CLU_115403_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="139" mass="14859" checksum="D476BB28564DD0DB" modified="2014-06-11" version="1">MPIPDRPRSLYDRHGRDAVRVGVAVSVRKEPTLDSTPWSLTIEQVGSETVLRASGALDLDTAGRLRSAATSALRQAHSAPTLTVDLAEVTFLDSTGLGVLVTLWHEARNAGGKFQVSRPSPTATRILEITGVDALFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQE5</accession>
    <name>A0A010ZQE5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1959"/>
    <dbReference type="HOGENOM" id="CLU_044041_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="313" mass="31918" checksum="81F7E2064A103A8C" modified="2014-06-11" version="1">MIGSDTERPPRVVAFGGGHGLFASLKALCLLGIEPTAVVTVADDGGSSGRLRREFGGIPPGDLRQALVALANPGDPVTAAVFQHRFPGKGELGGHAIGNLIISGLTDILGGTVEALEHASRVLGCRGRVLPMAAEPLDIEADVAGALGNVVTVHGQHEVASTKGQVRRVRVTPADAPACAEAVEAVKMADALVLGPGSWFTSVLPHFLVPELADAIVSSAARRIVVLNLSTDGETKGMPFDGHLHALAEHAPALKVDVVLADPHIVGDHTGLSRAAESLGGRLVVAPVAASDGSPRHDQQALANALRGVLGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQN0</accession>
    <name>A0A010ZQN0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_2079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850131.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015182_4_2_11"/>
    <dbReference type="OrthoDB" id="883503at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459210" description="Flagellar hook-associated protein 2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="8">
        <location>
            <begin position="201"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG80984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="45038" checksum="593B6EAFB763012E" modified="2014-06-11" version="1">MVTSLGGLASGMDTTSLINALITAEAAPQTNLKTKVSDYTTNNTAYQTVNNKMKAVLDAAKELTKFDAFKGAKATSSSTDVVATASTGAQTGDLTFSVTKLAAAHRVTSAFAGTDTPATSNGTFDLTIGTGGDAVTTSLTVDENTPQGVADAINKAGLSVRASVVTTDSGPVLQLASTKTGKANAFEVTGLTSDAKVMSAGADAELTVGDPDQGGFKISSSSNTFTGAMPGVTITASKLATDVTIGVNQDTEGIANKMQALVDAANSALAQISSSSAPGIATSPGAKSSAGPLAGDYTVRQLASQVLSTVSQGLSGFGSFKQMGVQLTQGGKLEFKKDDFLKAYAEDPAKVQKAVTDGLAGGLQKVGETATDTINGTLTQKIKSGTTMISRLNKEILDWDTKLADRRTALQRQFSAMESALAKVSSQSSWLSSQTAASNASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQP2</accession>
    <name>A0A010ZQP2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2507098_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="85" mass="8905" checksum="EA24BD59688CBA86" modified="2014-06-11" version="1">MSSVTENPEVVSDNVGQSDAVDAVELAEVVEEGIAAAYEQAAGAPVEAALETVLDEEQARGVELNEEFARPFAEAISRGEDPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR93</accession>
    <name>A0A010ZR93_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribokinase</fullName>
            <shortName evidence="6">RK</shortName>
            <ecNumber evidence="2 6">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsK</name>
        <name evidence="9" type="ORF">CryarDRAFT_0766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 6"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848493.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.753"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_11"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="8">
        <location>
            <begin position="5"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="287" mass="29046" checksum="CAEC74F26192AAC3" modified="2014-06-11" version="1">MNNFDIVVVGSLNIDVTVDVPQAPSAGQTLLGGDSRRSGGGKGGNQAVAAARLGRRTAMVGAVGAEDGEFLLNLLREEKIDLSGVRPVSAPTGQAFVFVDTEGDSTIVVSPGANDHVEVDRELVASARAVLLQQEVPAAVIEEAAAVADGFVVLNPAPARPVPASLLANVDLLVPNRGELLGLAGVDRGDLVQLAQGLGTRGPVVVTLGAQGSLVVEAERSTRVPAEQVKAVDATAAGDSFCAALADAILDGADVVEAARWATRVAAVTVTRPGAMASLPTRAELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRB6</accession>
    <name>A0A010ZRB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850417.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2267"/>
    <dbReference type="HOGENOM" id="CLU_043135_0_0_11"/>
    <dbReference type="OrthoDB" id="687646at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459160" evidence="1">
        <location>
            <begin position="32"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="40534" checksum="FB6CF4E00FA3A7C7" modified="2014-06-11" version="1">MKRPTTLGAAALTAAVLALSACGDEPEAAAAAKPVKQPVTVTYDGGILVLDGESLAVAHRIDLDGFNRVNPAGDDEHVFVSTTDGFRVLDAVDGTMTGISYPGAKPGHVVRHGDRTILFTDGTGEVNSFDPADLAQGKPSGRTYRTATPHHGVAVELADGTLVVTLGTEESRPGAIALDATGKEIARNEDCDGVHGEAVAKDDVVALGCNDGVLLYKGGKFVKVDGGREYARTGNQSGSDVSPVLLGDYKVEPDAELERPTHFSLIDTAANRLRAVPMPAGVSYTFRSLGRGPGGEALILGTDGKLHVVDPVSGRFTHAWPVVAPWQEPLDWQQPRPAYFVRGTDAYVSEPAAKMVHRLDLTTGEITGSVTLDGVPNEISGTLPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRQ4</accession>
    <name>A0A010ZRQ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569743.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098981_0_0_11"/>
    <dbReference type="OrthoDB" id="1742382at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="210" mass="23030" checksum="63464AD73D2B649D" modified="2014-06-11" version="1">MIDPHFVFLALLFNFLGAGIYVRKALLGRVRPHLVTWSLWAVVPYVAFLAQLSEGVRLPAFVTLVAGVSPTLTLLVSVRSRTAHWKTSRFDIGCGLCAVLGVVCWAVFADARYALVFAIVADALAAIPTFRKSFTNPESENWVQYACLTTSSVITLASLQVWTFAAYGWAAYLALLGAGLAATIGLRGRRARADERIVVRRATRRVSELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRS5</accession>
    <name>A0A010ZRS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850625.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2413"/>
    <dbReference type="HOGENOM" id="CLU_151796_1_0_11"/>
    <dbReference type="OrthoDB" id="1950120at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="109" mass="11678" checksum="A81FEE381F40EF92" modified="2014-06-11" version="1">MALPSLSPEQRAAALQKAAEARKQRAAVKDKLKHGGLSLSEVLESAEQDDVIGKMKVSAVLEALPGIGKVRAVQIMEKFKIAESRRVRGLGDNQKRALLTEFGSPSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRU2</accession>
    <name>A0A010ZRU2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ORF">CryarDRAFT_0995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.977"/>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EXG79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="930" mass="101839" checksum="4B0F301ACA445736" modified="2014-06-11" version="1">MPDTDAGPSDLWGLGSVAPDDANEADRELRADIRRMGNLLGETLVRQEGPDLLELVEKVRAAARTDAAAAADALSGTDIPTAIRLVRAFATYFHLANITEQAHRGRDLRRRRANQGGWLEGAAQRIKARGLTSEEIAAGAEQLAVRPVFTAHPTEAARRSTLAKLRRVADLLEAEATEAAVSGTPAAYVSRRTNRELAEVVDLLWQTDELRLEKPEPTDEARNAIYYLNDLHADAAPTVLTELADILADLGVEVSSTAKPLTFGTWIGGDRDGNPFVNAQVTRDVLKLQYEYGIRDTDADLAELVEELSVSDRVVGVSAELEESVAADLANLPELETRYRRVNAAEPYRLKIRCMRAKLANTRTRLARNAAHQPGRDYLGSTDLVADLEVMRRSLRAHRGTLIADGTVTRLIRTVSAFGLHLATLDIREHSGAHHQALAQFVDRVGELYEPYTALSREARTEYLARELAGRRPLGGPDVQLDEAGAKTFGVFGAIRDILDQFGPEVIESYIISMTEGVDDVLAAAVLAREAGLVDVNAGVARIGFVPLLEQVAELNVAGEILDRMLSIPAYRAIVAARGDVQEVMLGYSDSNKDAGITSSQWQIHRAQRALRDVAQQHGVRLRLFHGRGGTVGRGGGPTHEAILAQPYGTLDGAIKVTEQGEVISDKYAVPSLARENLELTVAAVLQATLLHTQPRQPQEDLDRWSDLMDKVAAPAQQAYRELIHDPDLPRYFWASTPAELLGALNIGSRPSKRPDTGSGLAGLRAIPWVFGWTQSRQIVPGWYGVGTGFAAAREAGLGDLLADAYARWHFFRTFVSNVEMTLVKTDLSIARRYVERLVDPGLRHIFDKIVAEHERTVAEILEITGEPALLDAQPVLQRTLAVRDTYLQPLHHLQIELLARYRADDSDPQLQRALLLTINGVAAGMRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRZ9</accession>
    <name>A0A010ZRZ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850762.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1831832_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15635" checksum="274C2043DA3F250D" modified="2014-06-11" version="1">MSDKTRFTERGVEEDLSGPEIMATFTWENTPELLHVGLSDLYSGGMQGGKVATVSTVWLPANRAMGEGIAEYETLVSGLAEHHDDFGGIERWHSRAEAEAGHRSMVEATRDRLMDAHSYTEIHVVDRDHKYRTDGPEFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSG3</accession>
    <name>A0A010ZSG3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851037.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2714"/>
    <dbReference type="HOGENOM" id="CLU_072993_3_0_11"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="13156" checksum="DE712F3E1A0B9660" modified="2014-06-11" version="1">MKIVRGPGPSEQRPATITGEAWFDPVLPGTDGTTITTVFFTPGARTFWHTHEHGQILQVLAGRGLICSDGGSPQALAVGDTVWVPAGERHWHGATTDSFLSHTAISLGVTRWADEVSDAEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSL2</accession>
    <name>A0A010ZSL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851105.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2766"/>
    <dbReference type="HOGENOM" id="CLU_157172_1_0_11"/>
    <dbReference type="OrthoDB" id="1841820at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="9778" checksum="F709CDD3A26688CC" modified="2014-06-11" version="1">MTPLDLTFTAVLGRVRPGDTWICVQMPDSATVFGTRGLVKVRGDIDGEPFRGAFMALGDGTHKLPVTAAVRKAIGKAEGDEVRVHLTERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSW5</accession>
    <name>A0A010ZSW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1341"/>
    <dbReference type="HOGENOM" id="CLU_069356_12_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="192" mass="19874" checksum="4DA9F70D4497CBBF" modified="2014-06-11" version="1">MAEATSIIAVQGWSGATVAAVATATGISTGAVYQHFPNKGALAAEVFRRATQRELEVLATVLTAAEPVSTAERLAQGVGLFAQRAILGRQLAYALIAEPADPPVLIERLTYRRRYNDVFAALIAEGVGKGEMVPQDAAVTAAALTGGVAEVLIGQLSEPVDGPGARSLVSELTALALRCAGVHVREATCPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSX1</accession>
    <name>A0A010ZSX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monosaccharide ABC transporter ATP-binding protein, CUT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851212.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2856"/>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="276" mass="29616" checksum="D749FE4989C4E776" modified="2014-06-11" version="1">MSTPLIEVEKIGKRYGNIIALADVSTSVHAGEVTCVLGDNGAGKSTFIKILSGAHPHSDGRLVVDGEERHFASPREALALGIATVYQDLAVVPLMPVWRNFFLGSEPTRRFGRLDTGLMKKTTKSELAAMGIDLRDVDQPIGTLSGGERQCVAIARAVYFGARVLILDEPTAALGVKQSGVVLRYVARARDRGLGVVFITHNPHHAYPVGDRFMLLRRGRSMGDHPKSEITLPELTALMAGGAELEALSHELAAELGEDSAVAQELSSEVSDLRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZSY7</accession>
    <name>A0A010ZSY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="2">2.4.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849154.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1367"/>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="463" mass="52232" checksum="4D4F77E64248A886" modified="2014-06-11" version="1">MSDRTSIVVVANRLPVDREVRADGSVHWRPSPGGLVTALEPVMRKRQGVWVGWSGDAGDAPEPFEADGIQIHPVPLSHREVDSYYEGFSNATLWPLYHDVIAEPEYHRSWWDDYVTVNRRFADAAAEAAPDNAVVWVQDYQLQLVPQMLRERRPDLRIGFFLHIPFPPQELFMQLPWRTQVIRGLLGADLIGFQLPGGAANFLRLARRLIDLKPRGSEVDFEGRTVRARSFPISIDFASIDAIAREERIAKRSAEIRDELGHPKTILLGVDRLDYTKGIAIRLKTFSELLQDGSVSVPDVALIQIATPSRERVEHYKVLRDEIELQVGRINGDYGNVGAPAVHYLHQSFSREELTAFYRAADVMLVTPLRDGMNLVAKEYVASRVDHGGTLILSEFTGAAAELKQAYLVNPHDIDGVKERVLQAINADPADARRRMRRMRRQVAEHDVSRWAADFLQAMGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT04</accession>
    <name>A0A010ZT04_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851259.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2896"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_11"/>
    <dbReference type="OrthoDB" id="326708at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="453"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="561" mass="61808" checksum="F4D44BCF680979E3" modified="2014-06-11" version="1">MSATETYRHARDLLLRHRTDYHRAVAEFTWPTFDGPFNWAIDWFDAYARGNDRTALWIVEEDGTENRYSFDDMVTRSDRLADLLAADGVGRGDRVLLMLSNQVELWESVLAITKLGAVIMPTTTALGPADLRDRVDRGRAAYVIANSADTPKFDDVPGGYGRLAVGGAVGWRSYADASGFPGTRREPLTTPDDTLLVYFTSGTTSRPKLVEHNQVSYPVGHLSTMYWIGLRPGDVHLNISSPGWAKHAWSNVFAPWIAEATIFVYNYTRFDADALQEQIRRCGVTTFCAPPTVWRMLIQADLSGGPGALREVVAAGEPLNPEVIEQVRERWGLTIRDGFGQTETSVQVANTPGQDVRPGSMGRPLPGVPVVLVDPVTGAPSDAEGELCLDLAARPVNLMVGYTDDPARHEEAMAGGYYHTGDVATRDADGYVTYVGRTDDVFKASDYKISPFELESVLLEHPAVVEAAIVPAPDPIRLAVPKAFVVLAAGWEPTAATAETILAYAREHLAPFQRVRRIEFADLPKTISGKIRRVELRTLEQQRFDAATSDVPEYRDDALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZT17</accession>
    <name>A0A010ZT17_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase component of ABC transporters with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851279.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2911"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="342"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="523" mass="55756" checksum="70E1CA9890EBEFC9" modified="2014-06-11" version="1">MSVLSVGERAHLRADAITVTLGARTVLNDVSVTVSPRSRLAIVGENGRGKTTLLHVLAGVRAPDSGVVRRAGTVGLARQALESRSGETVGTLTDEAVAPSRAALRALDEATAALTSDPDGSADRYAAALDAATRLGAWDATRRVDVALAALNACPDRSRALTTLSVGQRYRVRLACLLGAHHDILLLDEPSNHLDADGLAFLTDRLRGHSGGVALVSHDRALLHDVANEFLDLDPSADGRPHRYVGAYPAWQEGHRRDRERWEQEYAEQQAEHRRLTVAVEQARDRLDTGWRPPKGTGKHQRQSRAPGVVQALNRERAALDAHRATVPEPEPVLRWPALPARRGTTLVRASGVGVTGRLAPASVVLDAGDRLLITGANGTGKSTLLAVLGGALAPDTGTVTRAAGARIARLAQEVPQWPADRTAAELYAGEGSLAATGLLDRQARHTAVGRLSLGQQRRLDLALRLAERPELILLDEPTNHLSPLLVDELTAALRSTPAAVVVATHDRQLLADLADWPRLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTG6</accession>
    <name>A0A010ZTG6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569901.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1569"/>
    <dbReference type="HOGENOM" id="CLU_047522_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="36853" checksum="15891C3E4BD161DB" modified="2014-06-11" version="1">MEDRTLSRATIPPGVLTGLLDVADQHEVATGGWFAGTGLDRARLEEPGTLVSYRQAVTVIRRALTALPAGPLGLLIGNRDPLLTWGPLGTAMRSAATVAEAIRVALDYHQGSGTLVDFFSTHTDEETVVELVPRTREPDLLVFLTEEAFAGIVTLIRLTFGTSSGPTAAALTYPPPPWASAYARLWRFPVTFDSDRTTLTLPRTLETRRIPTANATHFEAALSATRALLDPDPVDALVAAVEGALRTDLRARKTATQVAGELGVSPRTLHRRLAEAGQGFGEIQDRVRRRHADTLLSNTRRSITAIAAELGYSDPREFRRAYKRWTNETPSQARRSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUE5</accession>
    <name>A0A010ZUE5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="260" mass="28193" checksum="51C42807BC191CEE" modified="2014-06-11" version="1">MGAVVKAVPTVLSGRTDRVAFAVGVSDTPTSDLFPRVRRVSENEALDRTRRDYDEVAELYDDMVRQGDQVIDALSAGMINAFADLVRAGGSVGAVVDAGCGPGQWTDHLDRAGIRAYGIDLSPAMIAIARRYRPDLRYEVGSMLRLDAGDESIAGILAHFSLIHTPPDLLPRVLTEFARVVEPGGPLLIGVQITDTADTNGWVPYDHRASPAYLWTLDALADRLREHDFAEIGRLRIVAPAPGKPPAGYLLARHDARSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUL2</accession>
    <name>A0A010ZUL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850009.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1946"/>
    <dbReference type="HOGENOM" id="CLU_093435_0_0_11"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="222" mass="23578" checksum="B4B4D9BE83616DEE" modified="2014-06-11" version="1">MTTWLRLLDWNVRGLRDDVDALVRTVRGVAPHVVVLQEAPRVVRWRARAASLARRCGLVVVQGGASGNLVLSSLAVTVRDAGVLRLPLTRFQHPRAAVVVRGSLAGAPFTVAGVHLGLTEPERVGHVPVLLGALAGNEPVVLAGDVNETGDGPAWSALAERLTDAGAADPTPTFSTRSPRRRIDGIFVSPGVPVRDYRVLTTPDVALASDHRPVMAEIGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUM0</accession>
    <name>A0A010ZUM0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="12" type="ORF">CryarDRAFT_1992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1957"/>
    <dbReference type="HOGENOM" id="CLU_014841_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="9">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="11">
        <location>
            <begin position="259"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="696" mass="76955" checksum="C276E66769D507EF" modified="2014-06-11" version="1">MPDPSTYRPSPGSIPESPGVYRFRDSRGTVIYVGKAKNLRNRLNSYFADPAGLHPRTYQMVTSAANVDWVVVTTEVEALQLEYSWIKEYDPRFNVRYRDDKSYPSLAVTLYEEYPQLRVMRGPKKKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGVFKRAGQIGRPCLLGYIDKCSAPCVDRVSAEEHRAIVEDFCDFMAGKTDQMLRRLEREMQRASDELEFERAARLRDDIGALRRAMEKQAVVFGDGTDADVIAFADDGLEAAVQVFHVRGGRVRGQRGWVVEKVEDLGVGDLVEQFCLQIYGSEDASEVVPREVLVPELPTDAAVLEELLSELRGSRVALRVPQRGDKKTLMETVKRNAEQAFNQHKLKRASDLTARSKALQEIQDALLLDEAPLRIECYDISHVSGTDIVGSMVVFEDGLARKSEYRRFAVRSGPDGPPDDTASLAQVLRRRFNRYLDAHVETGDLPEESDSGAEAPADRGVPVGIDPATGRPRKFAYPPNLVVVDGGAPQVAAAARVLAELGIEDVALCGLAKRLEEVWLPGDDFPLVLPRTSEGLYLLQRVRDEAHRFAITYHRQKRSKRMTESALDDVPGLGEARRKALLRQFGSLKRLRQASADELVSVPGIGRRTAEAIVAALAGDAAVPAARSAPEATKGTEKSGVRAAGTSVDAAESGVTPMRAGRHENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUR7</accession>
    <name>A0A010ZUR7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569985.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138345_0_0_11"/>
    <dbReference type="OrthoDB" id="1645839at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="165" mass="17138" checksum="8E2A3AF1E39919C5" modified="2014-06-11" version="1">MTQATTQLPSPKDVRDMLEELLGKDITVGDGNPPAAADLQKATVAVYIDDTNKVTGVSGMDLPLSAWIGAAIGLIPKGGAEACVEDGDLSKMVGENVREVCNIMAALLNREGTPHLRLEKESVYLPGEPAPADIQGRCVALGARLDLAVAVAGYGSGRLWISLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZV52</accession>
    <name>A0A010ZV52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850251.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031561_3_0_11"/>
    <dbReference type="OrthoDB" id="814346at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="285" mass="31758" checksum="3D74BDDE558DB269" modified="2014-06-11" version="1">MSALATVLVGLAVVVVIAAGVGIAAHVRHRRWGALTGGHAHNDYRHSRPLLAALDQGFTSVEVDIWPHQDERGVPRLLVGHDAEDLEYWRTLRGLYLDPLARRVAEHGGVLPGYDRPFQLLVEIKNDPEWCWELLAAELDNYTDMLTRFEGDEIHAGAVTVVITGKPPKKELAAAPVRYAACDGSLAAVGSDSPASLVPLCSEKWDWKFTWDGHGAMPDAERELLREWVAKAHAEGRTVRFWGVPAHSRRQRRAFWREMRDAEVDYLGTDDLSALRAFLHVPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVN6</accession>
    <name>A0A010ZVN6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CryarDRAFT_2356</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861818.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2320"/>
    <dbReference type="HOGENOM" id="CLU_020211_11_1_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459192" description="Histidine kinase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="336"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EXG81247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="545" mass="57857" checksum="E4F11B062AAA6CF4" modified="2014-06-11" version="1">MVVTSRRSTLAGQLLALQLVVIVVVLVAIAALSVAQSAATFDRVEGRRVAALAEQLADNPLVRTQLGEPAPGETLAPLVQTIRTQSGVTSVTIADADGIVVSSTDPLLTRGRLPLGSAGVADGRSWSGELRLNGSLELVAQVPVLGAEPQNLGRQLGVVVIGEASPTLQQRALDASSHLAIYLGLASVVGLLGSWLLARRIKRQTLGLEPREIAGLAEHREAMLYGIAEGVIALDPHDRVTLVNAVGLRLLDLPEECVGATLTELGVEGRLGEVLTGGARDEVVLRRGRVLVLNRMSVTKDGRRLGSVTTLRDRTELAQLEREMGSFRSSTELLRAQAHEFANQLHTISGLIQIGEYDEVVQYVEALADHRESLDLTLTSRIHDTAVAALLMAKSAQAAERRVRLRVSERTGLGRLEAEDAADIATVVGNLVDNALDAAAVADAGDDAWVEVELRHDTSTVEIVVRDSGPGIAPELAQEVFTRGFTTKAAEGGERGIGLALTRLVCKRHGGEVSVANTPDGAMFVARLTVGRPMEPVDARERVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVU8</accession>
    <name>A0A010ZVU8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg chelatase, cobalamin biosynthesis protein CobN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2401"/>
    <dbReference type="HOGENOM" id="CLU_419617_0_0_11"/>
    <dbReference type="OrthoDB" id="1226595at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458285" evidence="6">
        <location>
            <begin position="39"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CelD_N" evidence="7">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="656" mass="68845" checksum="DACBC7C741234DB8" modified="2014-06-11" version="1">MHNRRPAVISRLLVGAAAVLTTLALVAGCTGDDPDEDAAPDQDAPVGSWEPVGPTDAVVRTDQVGYGTTETKIAVLLAPRQADDAAFLVERQDGSVAMKGTVGEDRGSWSTRYPATYPIDVSELRTAGTYRIRVSGGVTAASQVFVVGASKELFGQVAADTVQFFGVQRDGEDVLSEPIPRRASHLHDDAAAVYEAPEFSEGDDLGAGLSTVDGAPTVDVSGGWFDAGDYLKFTHTTAYALTLMQLAQRGGDASIGNGKAIEGLSDETTFGMDWLDKMWDEKTGTLYLQVGLGSGGVDGIVGDHDVWRLPQDDDSASGDGKRYLRNRPVFRANSPGELISPNLAGRVASAFALAAQVEAGDDPTRARAHLDAAAKILSLADTDDPGTLLTTYPRSYYAESTWTDDMALGATEVARAGFVLGDDRWSTWAGQAAQWAGQMTGSGSKQPLNLYDVGPVADAELYGLMAETGNKPAGVTPEALIADLKTRLETGVSAARKSPIGAAAPMTQSDFTTKTFGWSAVAALYRRAAEDDSYDAFGTAQRNIALGTNGWGLSLVVGVGNTYPKCIHHQIANLAGDLSGKGKIATGAVLNGPNAASAFKSLTRSSTAKDCTGVDVSRFDGQDARFVDQPHAYSSVEPAIDFTATALLAVTLESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVZ0</accession>
    <name>A0A010ZVZ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2457"/>
    <dbReference type="HOGENOM" id="CLU_026634_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="453" mass="48270" checksum="C5D9E2F94414611F" modified="2014-06-11" version="1">MVGSTGRPRPPGPDIPADIEVRDLDREVRAELRALPKGAADTVARHLVAAGRFLDTDPALALEHAQAARLQAARIASVREAVGIAAYHAGEWKLAIGELRAWRRLTGSDAHLAVIADSERALGRPEKAIELAASPEAARLDTETRVELMIVAAGARQDQGDLEGALATLDVPELRTQRASDWLARLRYAYAELLLAAGQVDTAREWFVQAADADVDGATDADERVLDLDGFLFTEEGTEHDDADDERDLVEPFDEDESDDADDATSLDENATHDDAQDDDAQDDASRAQEDAPSDRDDAPSAQDGDGSDQDDFADERDDAYEVDAREDDLGAEVLLDREVSGDDDWDDDEDVADRPTDEQIAARDDQPVRDDQDGRDDQDGRDDEGRRGDVAGLVAGADGALVDESGSVGEGGDGRTGSAGTASGEPSSPAVVRGVASEENEQDHDGGGRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW76</accession>
    <name>A0A010ZW76_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_4123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852986.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4096"/>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_11"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="188"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="456" mass="48762" checksum="3CF2D8DE03EFCEDA" modified="2014-06-11" version="1">MTISAFDLFKVGIGPSSSHTVGPMRAAWSFAERLRRSGALTRVARVRCELFGSLGATGHGHGSVPAVVLGLEGERPELVDPVAAGPRVEAVREIGKLTLAGEHPIEFTLDDVVLHRRRRLDFHSNGMLFLAFDASGAELDRREYYSVGGGFVLDEDEAGRPAIVEDATPVRYPFTTGRELLDHTDATGLRISDVMLANELSWRTEDEVRGGLLHLWSVMQECVARGTHTSGVLPGGLKVRRRAAALHTQLDEQRDHADPLRAMEWVTLYALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYRDFVESYDEDGVVRFLLTAAAIGLLFKENASISGAEVGCQGEVGSACSMAAGALAEVIGGTPEQVENAAEIGIEHNLGLTCDPVGGLVQIPCIERNAIGSVKAITAARMAVRGDGQHHVTLDKAIKTMRETGADMKDKYKETARGGLALNVVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWC8</accession>
    <name>A0A010ZWC8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_2638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570099.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2602"/>
    <dbReference type="HOGENOM" id="CLU_015355_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG81522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="419" mass="43185" checksum="092DB9FFBEBA6BEE" modified="2014-06-11" version="1">MLFGHGWHAHPESVTAATVILVLVVVTALAFDFTNGFHDTANAMATSIATKALQPKTAVALSGILNLIGAFLSVEVALTVTNAVVKIQNKDGTPKDALVADGGQALLFIVLAGLAGGIIWNLLTWLLGLPSSSSHALFGGLVGATIAGLGFSGVNWNGDGSKLDGVVGKVILPALLSPVIACLIAAAGTWLIYAVVRGVAERYTNTGFRWGQIGSASLVSLAHGTNDAQKTMGVITLALIASGHWTDTENIPFWVKACCALAIALGTYLGGWRIIRTLGKGLVEIAPPQGMAAESASAAVILTSSHLGFALSTTHVATGSILGTGIGKRGAEVRWKVAGRMVTAWVITLPSAAIVGALLWYIGDVLGGGLFGAIVVFALLVAAAGYMYHRSRQKPVHAGNVNDEWDGADRPADRATETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWQ1</accession>
    <name>A0A010ZWQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mn2+/Fe2-transporter, NRAMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2732"/>
    <dbReference type="HOGENOM" id="CLU_055818_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="42154" checksum="69540A603156A8C3" modified="2014-06-11" version="1">MASETLPDRKTRRSALLGAIFLMATSAIGPGFITQTTTFTVTLGAAFAFGILVSILIDFVVQMNVWRIITLSGQRAHQIANAVVPGAGYLLAALIIAGGLVFNIGNVAGSGLGLNAALGLEPKIGGLLSAALAIVLFAVKRAGAAMDRVLIVLGLLMIGLTLYVAIASGPPVGDALRQTFRPDTIDFAAITTIIGGTVGGYITYSGAHRLLDSGTTGPEHVGEVTRGALASIAVTGLMRFLLFLAILGVVASGVVLDTAGNATADAFRAAAGEFGRRAFGLVLWAAAISSVVGAAYTSVSFFDAFSARLNPPRPRAWATVAFIAVTTVIYLLIGTAPAALLVFAGGFNGLILPIGFTILLYAAWRRRDVLGGHRHPAWLLVLGALVAVVTWYMGVVSVRTIFDYLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWV6</accession>
    <name>A0A010ZWV6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dyp-type peroxidase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851132.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2783"/>
    <dbReference type="HOGENOM" id="CLU_044178_0_0_11"/>
    <dbReference type="OrthoDB" id="837319at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="334" mass="36168" checksum="8990E45AAC72CEFE" modified="2014-06-11" version="1">MVKPVESQPVLTPLTEAAIFLVVVIRDGGEDTVRDLIPDIAGIARSVGFRAPEGDLSVVTGIGSDAWDRLFGGPRPAELHPFRELAGKHTAPSTPGDLLFHLRARRMDLCFELATHLTRRLGDAAEVVDETVGFRYFDQRDLMGFVDGTENPTGAAALEAAAIGDEDPDFAGGSYVVVQKYLHDIGAWNAQSVEAQEKIIGRTKLDDLELPDDVKPADSHVALNTIEDEDGNEQQIVRDNMPFGSVAQGEFGTYFIGYAKTPSVTEQMLRNMFLGRPEGVTDRILDFSTAVTGSLFFVPSADWMDDPPGPPEPVVDAETDGSLRIGSLKRSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX57</accession>
    <name>A0A010ZX57_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_2917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_3_11"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="126" mass="13719" checksum="FB64705F832BFA23" modified="2014-06-11" version="1">MYEAGTERGVRAFHTMPDMPPPEGEKHSHDYRLALVVSREQLDEKGMVVDLDVLVGALEDLTKQLQDNDLDEIVAPEIGKEAVTVEDFAHWVHGRIGAAIGTPGATLSVRVYENATEFGGYSGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX98</accession>
    <name>A0A010ZX98_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851305.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170283_0_0_11"/>
    <dbReference type="OrthoDB" id="2081425at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="101" mass="10326" checksum="F6BC90E7CCA91DF6" modified="2014-06-11" version="1">MRIPTAAITAGSLIGGWQVARRTGVRPLGGVVLVVGGALAGREWARRTSPAITGALVATYVGAFGLSHPLAKRIGGWPSVLTVSALTATASYLASDRRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYR8</accession>
    <name>A0A010ZYR8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725724.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3485"/>
    <dbReference type="HOGENOM" id="CLU_096188_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="179" mass="19210" checksum="5F93EDBD751D4A88" modified="2014-06-11" version="1">MRRLTVRRVVTGHDSEGRSRVVDDRDVEAITSALMPGFAAYRLWGGDEPPAFPNDGSPSGVATWFPPPEGSRFIVITHPPEGQTPPVGVDAAAATAELERQMPGMLTSMEPDGSGMHTSDTMDYLMVVHGEATLELDDGERAVVRVGDVVVQNGTRHVWRNYGTEPCTLVAVSVGGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYY7</accession>
    <name>A0A010ZYY7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570510.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355598_0_0_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="573"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="773" mass="82066" checksum="ABCBD4FC98F5E623" modified="2014-06-11" version="1">MVGPEAPRIARLIVLAVFFGYAVNTVNSTWTTLPWPQFATFVGCLVVLLPLQFLHSFREPLTWRAPTRLLTLTAQTLVTLVPLLWVGAQAAAMAGFLAGSMLLAVAGRVRWLLYAAVGVAVLIGLRAIHLGWVDILYGTYFTVLAGLMIFGISSLTSLVGLVFAGRGELARTAVARERVRIARDLHDLLGLNVSAIALRSQLVHRLLPGAPARAREELTAVLQVTRQSLADVRMVTSGSGPMSFAAEVESAESILAVADIEFQVVADPRDVPGEVENVLAVVLREATTNVLRHGRARHCAVRVRRGSTQIRLHVDSDGAEPDQGGSERPGSGERPGIGLTNLADRLAGVGGALTVAVAGQWFRLTAQVPLGDGSRRAPASTLDEAGLDDAAARIGRGRPWHLRVARSVAVAVTVGYAALTVVNVVSRPITVGSLIGFVACMAVQASVLIAYALGRRRRLPGRLRTGTLVLQLVAAALPLLWLDAPWGSMGGFLAGTVLLALPGRRGWLLFAAIGVAVAALAALEPGSFQWNVYLVISTLLTGLTLYGIGSLSSLVVQVNQTRDELARAAVARERLRLARDLDELLGRDLSQVAVACRSAHRHLATDPQLARTEMAAVLEVSHRALATVRAAASGYRYLSFSAELDSAASILEAAGVDLSIEASARPVPRTLDAVLSLALREAVANVLRHSDAARCRIRVCHTADDVRLDVTNDGAARSSDPVLESGSGLGDLAARVGQLGGRLVAHAHPDGTFELLIEIPTEPTETEDWERSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ10</accession>
    <name>A0A010ZZ10_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570528.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172512_1_0_11"/>
    <dbReference type="OrthoDB" id="2069996at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="72" mass="7737" checksum="66AFC530980910B6" modified="2014-06-11" version="1">MNAHRGDEILLQPPGAGHPVRDGEVIGVDDPDGFPPYLVRWSDGRTTLLYPGPDAQVKHLHGCGSPPDPTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZ48</accession>
    <name>A0A010ZZ48_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="35296" checksum="AE6BED767AE507A1" modified="2014-06-11" version="1">MTTPGITLLDAERFAELVTLGTRAPSLHNTQPWLFHRDGDAVEVFADPSRVLPATDPSGWGQRIAIGAAAYNLRLGYAQLGWRAETEPFPEAGEKHLVVRVHPVAEHRITPAERTVADAIPRRHTNRRPYLEAPVPAATLAALVHAADEEACRLTVLDARGVGEVSELIRDADAELERRRGYREELRRWCRDAGGPPDGVRWDRLTGRPHADERLRRRDFGAPTTSSDRRYESDPCLAVLTSSGDGRFDELRAGQALQHVLLRATSAGLTSSLYSQPIEVGAVRQRLSAVCGGGTPQMVVRVGYGLAHGPTPRRPIDEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZC0</accession>
    <name>A0A010ZZC0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570591.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3726"/>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OrthoDB" id="871215at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="344" mass="37744" checksum="D807E147179F86C9" modified="2014-06-11" version="1">MRSRTVVIFLFDGAQPLDFTGPYDAFTGAARYHSSPDGPPYVVRTASIGRRPVRLAGGLTVLPDLDIEDVRRPDILLVPGGPGAEVPNPEVAARLRTLGPEAERLASVCTGSLLLAEAGLLDGKRATTHWSFCGHFAQAYPRVHVQRYPIFVEDDGVFTSAGVTAGIDLALALIEEDCGRELALRVARLLVVFVRRPGHQAQFSAQLAVQSSGSTRLRDVRAWIADHLDEDLSVTALAERTRMSARHFARLFLSETGTTPGHYVEQVRVEAAQRMLTDTPDNVDRIARRCGWGTSEAMRRAFVRQAGESPAGYRQRNVSWAGGSPAEVRPVTRRRRPPRESSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZZT0</accession>
    <name>A0A010ZZT0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852662.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3902"/>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="193" mass="20804" checksum="CE74CFD7D301BCB4" modified="2014-06-11" version="1">MSVQERKQRERAERERLIVATARELAEQQGWDAVTTRLLAERIEYSQPVLYSHFRGKREIIGAVAIDGAIELAAAVRAAASGAHGPRARVAAVARAYLDFAAGNPAVYDAMFQLDGGLAFARDDTPEPLKDAFAALKESLDAVAGEGVDPGLFTEVFWAALHGVATLTRAGRLPPGDTARRLDLLVDRLAVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011A0C2</accession>
    <name>A0A011A0C2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_4143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4115"/>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="7">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="428" mass="46788" checksum="0F3D6B455F3E2A8D" modified="2014-06-11" version="1">MTATFTEVDTYDVRFPTSRFLDGSDAMNPFPDYSAAYVVLRTSDGDEGHSLVFTVGRGNDVQVAGVRALASLVVGLDVDEVLDDLGAFSRRLAGDSQFRWLGPDKGVIGMAAGALVNAAWDLRARRANQPLWQLLASLSPEELVGLVDFRYLRDALTPEEALEILRKPGREERATQLLREGYPAYTTTPGWLGYDDEKLARLSKEAVADGFAMIKLKVGGDREADLRRLRIARDAVGPDLPIAVDANQVWGVGEAIEWMADLAPYRPYWIEEPTFPDDILGHARIREAVHPIRVATGEHGANPVLFKQLLQAGAIDVVQIDATRVGGINDNVAILLLAAKFGVPVCPHAGGVGLCEMVQHLAMFDFVAVSGTRDDRMIEYVDHLHQHFVDPVEIRGGHYVAPVAPGIGARIHESSLTEFTYPDGPAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAJ4</accession>
    <name>A0A011AAJ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569525.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.54"/>
    <dbReference type="HOGENOM" id="CLU_030006_3_0_11"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="278" mass="31005" checksum="7B53D16071AA10B6" modified="2014-06-11" version="1">MRSDGPLVVAHRGSSAQLAEHTLAAYEKALVEGADGLECDVRLTRDGHLVCVHDRRLERTSNGRGAVSDRSLRDLDSLDFGGWKVDLPESADALVTTDRPYLDDKVRDAERRVLTFDRLLELFVDSGRPVQLYVETKHPTRWGGLVEQRVVASLRRFGLVPQHRSPDAADSTVVVMSFSPMAVRRLRELAPTLPAVMLFDGLPRLYREGTLPFGATIAGPGLHVLRSKPRFAERIHEAGNQLYVWTVDEPDDIKFVAELGADMIATNRPSDLLSYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAT4</accession>
    <name>A0A011AAT4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.152"/>
    <dbReference type="HOGENOM" id="CLU_055968_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="316" mass="31861" checksum="E19A73C86705BF0D" modified="2014-06-11" version="1">MDKVAVLGLGLIGGSVLLRSVSAQVAARVVGYDADPGTRAAAVERLGPAAVAADLATAVDGADLVVLAVPLPAVPAVLGALRDVGHRGLLTDVTSVKEPVRALVGEGTRFVGGHPMAGKEASGFDAADAELLVGCAWALCLDDETALPDWLDVARWVLAVGGQVAPLTSAEHDAAVARISHLPHLVAASLTAGAAAEPIGAAALGLGAGSFRDATRVAATRAALTAAMCGGNAAALTTEVDAMQARLAEARALLTGEDPIGALTEWLEGPRAIRAEWPPHRVRTELPLTRDALLALGRAGGRLTGIGTDTARATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AAY1</accession>
    <name>A0A011AAY1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase III, subunit gamma/tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_0204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847658.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.191"/>
    <dbReference type="HOGENOM" id="CLU_006229_3_5_11"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1064" mass="102852" checksum="58045C82EAB6B7FB" modified="2014-06-11" version="1">MANRALYRKYRPRTFAEVIGQEHVTAPLIQALKNGKLNHAYLFSGPRGCGKTSSARILARSLNCVNGPTPDPCGVCDSCLALAPDGPGSLDVVEIDAASHGGVDDARDLRERAFFAPVNSRFKVYVIDEAHMVSSQGFNALLKLVEEPPDFVKFVFATTEPDKVLQTIRSRTHHYPFRLIPPSTMVGLLDRICTDENVQIEKSVLPLVVRAGGGSARDSLSILDQLLAGAGTDGVTYQHAVALLGVTDSGLLDEATGALAADDGAALYGVVDRVVEAGHDPRRFASDLLERLRDLVILATVPDAAAKGLVDAPADELERMSLVANQLGVATASRMADVVHNGLVEMRGTTSPRLLLELVCARMILPAADESHAALLQRLERLERRLAIGAEGGFPPASVATVRTPVPTSSEPAPVAEPPRPTPPPVTPPRPAAEGGSAPVAVVPTQTPAPISRPAPAASAAPAAPAASAASATPAASSGPRASSGPGEAASAGSGSVVSTSPVSPAPAGSVSAGSDSAGPVPDAAPVSGGSATVGASSGGSATAGAASAGVPALAGSPAGGSAADGSAASAPAGGGPASGGPAAGGSAAGGPAAGGAASGGSAASAPAVSGPAAGGSAGSAGQPVAAYGAAPRPGVAGPAVAAAAAATSGMDAAQVRQVWPQIVDQTKQHSRMVWALVQNATPREVRGDELVVAVKHQGEVRRLSDDKCTSVLQKVLLDVLGVRWRIKAEVDGGSGGGGAGRRGPAPPPGPVPMPAMPPMPTAASASASGGSDWPTIAPVGGLPPAPAAGAPASTTSGYGAGDPASGGHGAPGSASGGYGTPGSAPGGYGAPGSTSGGYGSPSSAPGGYGAPGSPPGGYGAPGSAPGGYGSGGHDNVTPGGHGTGAPVPGAPGVGGTAPGGYGSPAGGHTGPAGGNPGQAGHSGNSGYAGGPGNSGGPGNSGGPGNSGGSGHSGNSGPAGYSGQAANTGYGGNAGPGSGHSGSASSGYGNSASASNRANRRGSVGVMDDDVPLPPEPSDPMYDGFDPGDEPLDDEDEAGTAKAVDSEKDAIALLEQHLGARQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABH9</accession>
    <name>A0A011ABH9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847969.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.390"/>
    <dbReference type="HOGENOM" id="CLU_097916_0_0_11"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="18170" checksum="85AEA508440D6A57" modified="2014-06-11" version="1">MTRAVLSIGSNLGDRLANLAGVITALPGARVSPVYETDPWGPVPQDDYLNAIVVAEDAGRDAAGWLSFVREAERAAGRVRDVRWGPRTLDVDVVQVHDVRGEAVLSEDPSLTLPHPLASQRAFVLVPWLAVEPDAVLAGHGAVRELVDALPDDDRGTVRRRDDLSLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABI6</accession>
    <name>A0A011ABI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069607_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="305" mass="31294" checksum="456D961F6957532E" modified="2014-06-11" version="1">MSAAKQYALVPGAFVPVPTLRPRTAAADVPALTTGFPTGRLFRSELRLMFGRRRNLAALAMLAAVPVVIAVAVRWSGPRTGGEGPAFLSLVNGNGLFVALTALTVALPLFLPLAVSSTAADAIAGEASLGTLRYLLTVPVSRTRLLLTKFAAVVTYTFVAILVIAAAGAGIGLLLFGAGPAALLSGAQVGLGEAMLRLGMVCVYLTLCLVALAAVGLFVSTLTEQPIGATIAVVATAITSQILGAVPQLEVIHPILLTNYWTAFGELLRDPISYGALAPGLISALAWTAVFASAAWARFGSKDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABK8</accession>
    <name>A0A011ABK8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+ family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848023.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.425"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_15_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="171"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="426" mass="45445" checksum="7A8FD1E8EEBF7B62" modified="2014-06-11" version="1">MRPAEEDPLLASLLAAVAAAAGDIPLRLHVAGLLLDRGRAAEALEHCSTVLRSDPANEEAIALLRRASAELGAARPGSRVAADRPSADPAMVGRSGFDWDAAEAQVQDLPEVGRVDDGLPDPVGEGDVDGLVFTDLSLADVAGNPDAKERIERAIAPIRNPALARAFGKRTTGGLLLYGPPGCGKAFVARAIAGELQANFYRVGRADLLDRPAPTAELLASNPAAERRMHAVFATARRSAPCVLFLDDVDGIGPKRSRLQNPSTLRAVVNQLLFELDSLNRADSGVFVLASTTRPWDLDPALRRAGRLDRMVLVAPPDAVARTAILRFQLRDRMIADFDLTEVAEAAAGYSAADLRRVVESAADSALSDSLRRGQARPIEAADLVAAIKRVRPSVGTWLDLARAAAGPSDGSYEDLHLYLRTHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC47</accession>
    <name>A0A011AC47_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_0652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848365.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.638"/>
    <dbReference type="HOGENOM" id="CLU_005108_5_1_11"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG79611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="726" mass="77036" checksum="F66F7F6BA0ED24AD" modified="2014-06-11" version="1">MFERLGRTMVRRRWWVLGLAVAFIAFAGIWGTQVFGKLVGGGFDDPASESSRALTRAEAELGRDGNDVVVLYRSSTLTADDPAYQQAVTSTLADLPSDVVTGAATFWSTKSPTFVSKDKHETFAVLTLAGDDEETRTDQLEQIEGKLAAPGLESEVGGNTAINRDINERVSADIAKAETLSMPVLLILLVIIFGSLAAASLPLAVGGLAILGAFTALRGLSYLTDVSIFSVNVVTILGLGLAIDYGLFMVGRFREELARGLSVEDAVARTMGTAGRTVAVSGVTVAVSLAGLLIFPITFLRSMGLGGLSAVLIAMIAALTVLPALFGVLGHRVDALSVRRLFSKRRQSRRKPQANSEVEHGFWYRLARSIMRRPVIYTVGVLAVLLIAATPFLRVEFGGIDARALPAGTESRVVSETLDRDFVPNSQSPIDAIVTSSSSGLDQYVADVRTVDGVTGASVTAQSGDTARVSITYDGDPISAESRELVSRIREVPAPSGGEVLVGGQTAALADQLKTVGDRLPWMALIVVSATFVLLFLAFGSLVLPVKAIIMNVLSLGASFGALVLIFQEGHLSGLLNFTSTGTLEATQPILVLGIVFGLSMDYEVFLMSRMREEYDRTGDNTQAVAVGLQRSGRIITSAALLILVVIGLFSISGITFIKLIGVAMLIAVLVDATIVRALLVPATMRLLGNLNWWAPGPLRRFYARYGIHEEGTPTPPAPVPAGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACM4</accession>
    <name>A0A011ACM4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CryarDRAFT_0816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860513.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.804"/>
    <dbReference type="HOGENOM" id="CLU_029920_1_0_11"/>
    <dbReference type="OrthoDB" id="1195697at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="260"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="499" mass="52819" checksum="BD7C5BC7F244A592" modified="2014-06-11" version="1">MSGRLYGVGLGPGDPELVTVKAARLISAAEVVVYHSARHGRSIARSVAAPYLREGQIEEQLIYPVTTEATSHPGGYQGALDEFYESCAARLAAHLDAGRDVVVLAEGDPFFYGSYMHLHKRLAPRYEATVVPGVTSVSGASATLGRPLVERDEVLTVLPGTLPSATLAARLAGDDPAVIMKLGRTFGAVREALETAGRLDEAWYVERATTPSERTAPLADVDPETVPYFSIAVLPSRLSPGLSDLAPAPAAPSTASTGEVVVVGLGPAGREWQTPESQAALAAADDLVGYGPYLDRVPANPRQRRHPSDNRVEAERAAFALDLAARGARVAVVSSGDPGVFAMAAAVLEVAEEPRWKHVPVRVVPGLTAAQAVASRVGAPLGHDFCILSLSDRLKPWDVISSRLAAAAAADFVIAIYNPASKSRREQIVAAKALLLEHRDADTPVVVGRDVGGPEESVRIVRLGELDPADIDMRTLLIVGSSQTRTDGHTVYTPRRYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD16</accession>
    <name>A0A011AD16_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.982"/>
    <dbReference type="HOGENOM" id="CLU_017353_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="567" mass="62853" checksum="4755C39EB046C8D9" modified="2014-06-11" version="1">MSSPYPGRTPNQAGGVGPGYAGAPPADGQRHLPPTSVIPTAPAYPAPGPQTAVPRQQNYPAAPGGGGDLTPELLETSVWSDQMIAAAGIPVVDIPFVTIGGGIGSFVTVDYLRIAGVPTQNIRILSNIDNPWQTYEYLTRVSQIPRPERIRSDSASRPDNIWGFPSYAMEETIKDKSLKAAWQVLVEPMFADFYTPRAGMVFENLEREAKRIRWWEMLVKGQVRMVRRRHGGGYFTILTPPDGAAPTKRVAYRSQYVHVGIGYPGLKFLPELQEFRTKHQDFHHVVNAYEDHEHVYTFLKSRPGTVLVRGGGIVASRVLQRLMDDREKFGLQTQIVHLFRTYVSGPHGKNAWLRRPGSNGFAYQGFNYPKSVWGGQLKAKIRKLEGAERAQAYKDMGGTNTPWRRRWQAQMNAGRSGNWYHTLEGVAEDVTIGADGRTVSRVKFGNGQVSEIPADFIIDCTGLEADIREHRLLADLMDHSNVGRNPVGRLDVERSFELKGTANGEGRMYASGSPTLGGYFPGVDTFLGLQVAAQEIADDLARRGFAKRIGPARSVSEWLKWARNQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADK2</accession>
    <name>A0A011ADK2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848923.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1176"/>
    <dbReference type="HOGENOM" id="CLU_009583_10_1_11"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="387" mass="41139" checksum="7003AD2961760F5D" modified="2014-06-11" version="1">MRIVRLANFVGPRSGGLRTALHELGRGYRAEGHDPVLIVPGPRFTDEDTPQGRVITLPGPTVPWMGGYRVVLGRRRLITVLDELRPDRLEVSDRTTLRWTGAWARRRGVPSLMVSHENATALLGLALPRWAPVRRIADALNERTVSTYDTVVATTAFAAAEFRRIGATSLVTVPLGVDLARFHPGLHSAALRGTLARPSELLLVHCGRLSPEKKVERSVDALAALRSRGVPAVLVVVGDGPRRSALERRARGLPVKFLGFVPDRDLVAQLLATADAVLAPGPAETFGLAALEAMACGTPVVAAGDGALGEVVGDAGVAVSQGTGVRFAEAVLELAARPEADRRAAARFRAQRFDWATAVSGMLAAHGLEGGVESWSGTFASRPSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADN9</accession>
    <name>A0A011ADN9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035860925.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1218"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="254" mass="25861" checksum="386B1CDF13215F98" modified="2014-06-11" version="1">MFSSLAGRSVIVTGGSRGIGKGIARVFADAGASVLIVGRDLDAARATADEIGANAFAADIATPDGCRRMAEAAIERHGGIDVLCANAGIFPDRKLADLTEADVDEVFGTNVKGTIFAVQACTSALAASGHGRVVLTSSITGPITGYPGWSHYGASKAAQLGFLRTAALELAPAKITVNAVLPGNVLTEGLVDLGQDYLRTMEASIPLGRLGAVEEIGNTCLFLATDEAAYITGQTIVVDGGQTLPESLDAIVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADW4</accession>
    <name>A0A011ADW4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer DM13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089192_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM13" evidence="1">
        <location>
            <begin position="51"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="172" mass="18392" checksum="D10A6FAB474CEF79" modified="2014-06-11" version="1">MRRPLLFTFVAIVGLGIGAGLALFEPWRIFTSTTVEETIPSAPAGTAAPAGQSTETTVLARGTLITHEHETTGTVAILRLPDGKRILRFEDLSTSDGPDLRVWLSNAKVVEGTAGWTVFDDDKYLELGELKGNKGSQNYSIPADADLETLTSVSIWCARFHVSFGAAELAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGN5</accession>
    <name>A0A011AGN5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate kinase</fullName>
            <ecNumber evidence="1">2.7.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2239"/>
    <dbReference type="HOGENOM" id="CLU_132654_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="160" mass="17983" checksum="70F15027A5DFB407" modified="2014-06-11" version="1">MTVARILVTGMSGAGKSSVLDALRARGHHAVDTDYDGWTQPDGTWDEPRMERLLAANDDVVVSGTVDNQGRFYDRFDHVVLLSAPLPVLLDRVRRRRANPYGRTAAQRAEIAGYVSTVEPLLRRGATRELDTRRPLADVVGEIERLLQPTEELLRDRHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHR2</accession>
    <name>A0A011AHR2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570111.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2639"/>
    <dbReference type="HOGENOM" id="CLU_033536_7_5_11"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="227" mass="23959" checksum="91095AA8F7280C3A" modified="2014-06-11" version="1">MSKPEAHRPVAVDVVFPCLNEALSLPWLLGRLPDGYRAIVADNGSTDGSADLARELGATVLAVPVRGYGAAAHAGLEASTADVVCFCDADGSLDPAELPRVADPVARDEADLVIGRRRPTARRAWPAHARWANAVLSARLRRRTGLRLHDLGPMRAGRRAALRGLDLADRRFGYPLETVVAAAGAGLRVAEVDVAYAPRTAGSTSKVTGTLGGTVRTVVDMGRVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIK7</accession>
    <name>A0A011AIK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851293.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2922"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_11"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="274" mass="29176" checksum="7ECB28E68084C63B" modified="2014-06-11" version="1">MTTLNGRRALVTGGASGIGAATVRALVTAGADVTIATRDPRRADALRADNVHVRALDLADLDSVAGFTWDGPLDVLVANAGVMALPTRQLSPQGWELQLATNYLGHFALALGLHPHLAAAGDARLVVVSSGAYRNGPFDFDDPQFARRRYEPFLAYAQSKTATLLFTVGAAGRWAADGIVANAVNPGYVHTELQRHLDDDTMRAFGAMDEAGNLVTPDYYRTPEQAAATSLLLATATTTGGYYEDGHEVAPEPFASDPEAADRLWRLGEDTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIL3</accession>
    <name>A0A011AIL3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="194" mass="20966" checksum="95F534EEAD79EFB8" modified="2014-06-11" version="1">MTSVETLTERRRQATLLELSDVAAELFVRRGFAATTVQDIADAAGVSARTFHRYFPSKADALGPTMRAGLLYYVAQVAALPVGSPLVEGLCDALERVLAEPRTPLDNDVTRLTVTTPELTPVWLRAHEECAIALGPALAPHLEPGADEVVVRYAGASVVTANRLAVESWVAHGGEPRPYLERCLRLLTRGVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIQ7</accession>
    <name>A0A011AIQ7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851370.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988912_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="125" mass="13374" checksum="0105F1965200EA54" modified="2014-06-11" version="1">MGLVEELEAQREALTEACAVADAEDRVAQARCDQLLSEFAGTARQLQVRAAEFAAVTEGGSPQSEVSAAACAVDAARVDAMRAQLRVVDEWAAITKSRLTRARRLSQQVSSICDVTLDLERTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIR2</accession>
    <name>A0A011AIR2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851381.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2986"/>
    <dbReference type="HOGENOM" id="CLU_069356_21_2_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="184" mass="20420" checksum="C72ADCA5A9E7F60E" modified="2014-06-11" version="1">MTSRRRYEPDRRQRLIEVTLDVVAARGVAGTTHRRVAAAADVPLGSVTYHFTSLDELLTAAFTHLAETEAALFEARMSAIEPGTDARARVVDTMLADLADNQRSAVLTYELYAAAARDPSLRTITQSWMERTRRLLELHFDPETAEALDALIEGLILHATLSTRPVDADVIRNAVRRLVPDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AIV0</accession>
    <name>A0A011AIV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851463.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3030"/>
    <dbReference type="HOGENOM" id="CLU_083287_5_0_11"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="170" mass="18147" checksum="CAADF2A27E563F0B" modified="2014-06-11" version="1">MSTRSSAGDALTDAVLPVFELNGELLAAARDISEPAGLTPAWWQVLGATLDQPLSVSDVARRVGLGLARQSVQRTADLLVEKGWATYGANPHHRRAKLLSPTDTGRATLERLRDAQHAWADAVGADVGEEALRAFVDTAQRIAEASRAYRAGQLSRPAGRSAPRARDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJP1</accession>
    <name>A0A011AJP1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3327"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="32086" checksum="6211FA2BEA221937" modified="2014-06-11" version="1">MGICMRALIVDHAQPSGLRLGDVPPPTRGPGEVLVEVGAFALNNGDLATAIDMGDGDVPGWEAAGYVIEAAGDGSGPAVGTPVTTFGVTGAWAEYRAVDVGMLGTAPKGADLAAISTVPVAANSALRALRRSGPTLGRRIMITGATGGVGRYAIQLARMAGAQPVAVTRYPDEFADELRGLGADAVIADPADCPDPVHTVIDTVGGPLLVRAFDRLDNGGVLIALGHLATGAESFPRGALMAGPGQNRTIVSFHQFDGTPLGPDFTWLSEQLTRGALLPSINWRGSWQHVHDAITALRRGTLHGKAVIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AJS2</accession>
    <name>A0A011AJS2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570388.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_11"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="131" mass="14693" checksum="57C8598F8160EEE1" modified="2014-06-11" version="1">MTQLPIRPSPEGAAAECRRVQSVLDTVGRRWSGGIMVAASRGARRFTDFRRAVPGISDRMLSQRLKELENLGLLSRTVVPSTPVQILYEPTARGLELLQLLQPLFRWGEKHLPALPPDESLIPTESEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFP3</accession>
    <name>A0A010YFP3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.63"/>
    <dbReference type="HOGENOM" id="CLU_079880_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="226" mass="25720" checksum="ADCC2CDA5DE19B07" modified="2014-06-11" version="1">MNDLVAAVRAALAAAADPDRAPGMQAYMKSTMPYLGVAKPVRAEALKPVFVEHPLADRASWEKAVRTLWHEATYREERYAAIDLTGHRAYRQFQDATTLDLYRELVVGGAWWDYVDEIASRRVGPILRTDRAGVTPVIRTWSTDPDPWLRRTSIICQLSFKQDTDLELLTDAIAANAADQDFFLRKAIGWALRQYAWCDPEWVRAYVSAHESELSPLSRREARKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YG26</accession>
    <name>A0A010YG26_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.195"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015595653" evidence="1">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="552" mass="60109" checksum="B71AD6F7FDE22FEE" modified="2014-06-11" version="1">MYRVRRALAAAVSVGLAVSLAACADSERGEGGEGDNNATLTIAGTGKPKNFDPIFNDDGESFRPARQIYDTLIQNKAGSAELEPALATKWDVSPDGKQITFTLREGVKFQDGTDFNAEAACFNLDRWFNMKGAAAQSQMIYYQDVFGGFAKNETDAGGDPYYKGCQATNPTTAVMSLNKFRGALPAALTLTAFSISSPTALKKYDADKVTQSGDSFTYAAYATEHPVGTGPYKFESYDASNGTTTLVRNEDYWGEKAKTAKLVIRTIEQESARKQELESGAVDIIDFPAAQDWKALEGKGMKVEVRPAFNVLYLGMNEKNPKLKDLRVRQAIAYAINREQLVKTKLPEGAEVAKEFMPKTLTGYADDVTEYKYDPAKAKQLLAAAGATNLSLKFYYPTEVTRPYMPDPKAIYTSIAADLTAAGIKVEPVARPWNGGYKDDIQQAGKHDLHLLGWTGDFNDAYNFVGTFFGREKPEFGFTDKAAFAAIAAADGEPDATKREEAYKQVNRDLLGKYLPALPISHSPPAIATAGNIDGLVASPLTDERFYTVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YGX4</accession>
    <name>A0A010YGX4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription regulator of the Arc/MetJ class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848250.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.553"/>
    <dbReference type="HOGENOM" id="CLU_150044_0_0_11"/>
    <dbReference type="OrthoDB" id="1893426at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014447">
        <property type="entry name" value="UCP006909"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006909">
        <property type="entry name" value="UCP006909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="106" mass="12129" checksum="E8620C96E3402C28" modified="2014-06-11" version="1">MIFKAVRDGKPYPEHGLSLREWARIPPRQVRLDQLVTTKRELALDKLLAEDSTFYGDLFPHVVEFDGALYLEDGLHRALRAALQQRTTMHVRVLLYEPASDTPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJD6</accession>
    <name>A0A010YJD6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849176.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1381"/>
    <dbReference type="HOGENOM" id="CLU_099824_2_0_11"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="172" mass="18928" checksum="C525ACC26375D5DC" modified="2014-06-11" version="1">MPGTAVSLVLNATYEPLCVVPVRRAAVLVLTDKAVPVTEGDGLLRSTTTMVVAPAVVRLTRFVKVPFRGQVSLTRRAIFARDGGRCAYCTSSATTIDHVMPRSRGGRHVWDNVVAACTRCNHVKADRTLTELGWRLRRRPAAPTGVAWRVLGHRTPDPLWYTWLDIPEQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJL5</accession>
    <name>A0A010YJL5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_1504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849303.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1477"/>
    <dbReference type="HOGENOM" id="CLU_027579_1_0_11"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG80430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="407" mass="43223" checksum="226696A90BCEF97A" modified="2014-06-11" version="1">MAGPPPDGQPAPDDGHLPESALNRLGERGFGIYVHVPFCAARCGYCDFNTYTPSENAGSAETWLAAALAEIDLAGTVLAPAPGGLPRVDTIFVGGGTPSLLPVDYLARVVERVGDVFGLTSGAEITTEANPESVDAGVFSSLRSAGFTRVSLGMQSARSHVLAVLDRRHTPGRAVQAAQEARAAGFAHVNLDLIYGTPGETDEDWAASLAAVVAAGVDHVSAYSLIVEDGTRLARQIGRGVLPMPDDDVLADRYLMADEALTGAGLHWYEVSNWAADEAARCRHNELYWRSGDWWGVGPGAHSHVGGVRWWNVRHPARYADRLAAKTSPAQAREVLEPDDRRVEDVLLRLRLAEGLPLSALDATGRTAAVRATNDGLLDGGAHRQGRAVLTLRGRLLADAVVRALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJT3</accession>
    <name>A0A010YJT3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CryarDRAFT_1585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569900.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1557"/>
    <dbReference type="HOGENOM" id="CLU_028808_1_0_11"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="306" mass="31447" checksum="3BFA8658DD4727F6" modified="2014-06-11" version="1">MTVSVLADAPPSFWHQIFNFDDYGQLLALVHNSLIAGAVLGVVGGLAGVFVVMRDLPFAVHGISELSFAGASGALLLGANVVVGSLAGSVIAALLIGVLGSRARDRNSIIGVLMPFGLGLGVLFLALYKGRAANKFGLLTGQIVAVDTPQLSWLVGVSVVVLLGLLAIWRPLRFASLDAELAAARGVPVRLLSLAFMLLLGLAVAVAVQVVGALLVLSIIVTPAAAAARVTVAPARMVAFSVAFAVVSLLGGILLALGSSVPISPYVTTIAFAIYLVCWLIGARRQRRGWSSARALPSRTPVVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKA9</accession>
    <name>A0A010YKA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849669.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1724"/>
    <dbReference type="HOGENOM" id="CLU_027853_5_3_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="290" mass="30873" checksum="4EA5DCC8CEDB4DC2" modified="2014-06-11" version="1">MTTLGVVFRPQVPPERLRAVARAADDAGLEELWLWEDCFWQSGIAGAAAALSATERLRVGIGLMPVPFRNPVLATLEVATLERMFPGRFLPGFGHGVQDWMGQVGARAASPLTLLRENVDAMRALLRGEELSVSGRYVKLDKVKLDYPPEQAPPILVGAVGPKTLRLAGEHADGTILDSQKTVSDVREAVAMIGEGRAAAGRTDPHSIVYMGVAVTGPDAEARLQAELDYWKYDPASGLGVAGGAEAFAAEAAKFAGAGADTMIFQPPADEPDLEGYVRFVAQEVRPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKC9</accession>
    <name>A0A010YKC9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849711.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1745"/>
    <dbReference type="HOGENOM" id="CLU_008325_1_1_11"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="321" mass="34959" checksum="06591222BE52BDDB" modified="2014-06-11" version="1">MADMELDGVSLTNLDQPLFDGADATKRDLVEYVDALHERMITHLRDRPLSVIRVRPGQQPFMQKNVPKYTPEWVPTVEHWAESSHRQISYALANDRRTLLWLANQRAIEYHPALVRAGQWHTPTHLIMDIDPPEGRPFGVAAAAGLLVRRALEDLGLTGAVKTSGAKGLHIFVPLDGSSGPEDVAAATRALAARAARLDPSLATTAFIREDRGDKVFLDSTRAGGATVVAVYSPRIRPGVPVSFPVAWDELESVTPGDFTLRTAVGRLGELDPWAEAMPAPQALPADLIAEGHTIPIARVQAMHEGKRRKRAAEKGAEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKE4</accession>
    <name>A0A010YKE4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849730.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1762"/>
    <dbReference type="HOGENOM" id="CLU_065561_0_0_11"/>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="89"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="40125" checksum="878E86B87C021F3F" modified="2014-06-11" version="1">MSIDTVPTRQVDPAEATYAGELEFLARFDTGPRPPGWRLTPRAVVTFVLGSDGQELRAGTERLVVSPKFVGDRALVERCVVTLAGERGLLLVGEPGTAKSMLSELLAAAVSGTSELVVQGTAGTTEDHFRYGWNYALLLANGPSPEALVPSPVLSAMRTGAVGRVEELTRCLPEVQDALVSILSDRRIAVPELTGTPYATAPAAPGFTVIATANIRDRGVSEMSAALKRRFNVETVGPIPTLADEIALVKRRATTSVARSGAAFAVDDAVLEALVTAFRDLRNGESVEGWEVQRPSTVMSTAEAVAVATSLALAAAYFPGDRDVLSLLPGHLRGVAAKDDPADAATLLGYWDGSVRRRAEDGSRLWRQLWELRHAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKN3</accession>
    <name>A0A010YKN3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1817"/>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="256"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="486" mass="51363" checksum="BABF48630BF8B522" modified="2014-06-11" version="1">MNVDGISSFAAVDLGASSGRVVAGRVGPDTLELTEAHRFVNEPVRLAGTLHWNVTGLYAEILRGLRFLGRDHAVPRSIGVDSWAVDYGLLDAEGALLGAPVHYRDERTEGVAAAVAAEIGAASLYRRTGLQTLPFNTVYQLVAGRKSAAYQAAGALLLIPDLIGYWLTGAQGAEVTNASTTQLLDVHRRSWDVELATDLRLRPELLPPLRQPGDRLGGLREDVAAEVGFDAPVVAVASHDTASAVIGVPAVGDRFAYISCGTWGLAGLELDRPVLSEASREANFTNEAGIDGTVRYLRNVMGLWLLQESVRWWERSGSGSDLPTLLADAAEVPAGRTVIDVDDARFLPPGDMPSRIAAFARETGQPVPATRGEVVRCILDSLALAFRRTIHQASSLASHDVDVVHLVGGGARNALLCRLTADATGLPVVAGPVEATALGNVLVQARAAGVVGDLGEARALLAATQPTVRYDPRPGIDWDTLAARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YKS5</accession>
    <name>A0A010YKS5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035861493.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191180_2_1_11"/>
    <dbReference type="OrthoDB" id="2077016at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="61" mass="7051" checksum="C40CF0DF714EC4A3" modified="2014-06-11" version="1">MAEETRYWWNLKHKRVETDDDRGKAADRLGPYSSREAAEKALDTVAARNAAADAEDRRWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YL87</accession>
    <name>A0A010YL87_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850146.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2059"/>
    <dbReference type="HOGENOM" id="CLU_033198_0_1_11"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="460" mass="48735" checksum="039E14889812D031" modified="2014-06-11" version="1">MAAPTITPVDPTVAPRRSGRWIDDWRPEDPAFWASGGAAIARRNLIFSILSEHIGFSIWTMWSVLVLFLPADAYGLTPDDKFLLTAVPAFVGAFLRLPYTFAVAKFGGRNWTIVSASLLLVPSILTAALLEPGVSFGTLLILAAFAGVGGGNFSSSMANINAFYPNRLKGMALGLNAAGGNLGVALVQVVGLIVLAAAGGVAASVEPRLVPGLYLPLILVVTVLSAVRMDNLTHASNDKRAMRDVVRDRHSWIMSLLYIGTFGSFIGFSFAFGQVLIAVQGVTPVDALKVIFLGPLLGSIARPAGGWLADRFGGARITLWTFVGMGLFAALVLMASQQKSLALFYVGFIALFVLSGVGNGSTYKMIPAIFRAKAQRNAADGADADWEVNEARRLSSALVGVAGAIGACGGALVQIVFRQSFLTYQNADAAYVGFIALYAVCFAVTWFVYLRRSPSRLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLE7</accession>
    <name>A0A010YLE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus assembly protein PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850206.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050686_0_0_11"/>
    <dbReference type="OrthoDB" id="1750212at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019169">
        <property type="entry name" value="PilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="339" mass="35380" checksum="3BDD08BDF6FFCABB" modified="2014-06-11" version="1">MGKTSVIGLDIGSTSVRAVETDQERGGAVVTAVGEVPLAPGAVQAGVIQDEGAVTDAVRRLRASAPLRAKNTVLGLTSAQTVVREMTVANLPRKEMRTSLPFQVGDMLPLPVDRAVLDFLPLETSDRDTVRGLLVAAPKASTLSAVTAVEAAGLTVTRVDLASLALIRALAQVDGEAEAIVDIGAQLTQVIVQIDGQPLIVRTIPRGGAEVTTAVANRLRVETEEAEQLKRQIGLNREQNAEVADAVNEAIRPLMNEIRGSFAYLTAGGSAAEVARLVLSGGASLLQGLRWALADQLDIPVHAADLFRRLRGYRGENVGDTAPSPSCAIAVGLTLGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YLY9</accession>
    <name>A0A010YLY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2298"/>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13463">
        <property type="entry name" value="HTH_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="140" mass="15454" checksum="5116F2A059C25432" modified="2014-06-11" version="1">MAVDEVAASLLYQVMAVAGQVTGRMQEGLERLELTGPTANLLWVLDPEGDPQSLRRLATLLHCDPSNISLLSAQLEERGLAERRPHPRDGRVRTLVLTPEGRKVRRRLLDVVAKRSPFAELDATEQRVLQGLLAKALKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YM72</accession>
    <name>A0A010YM72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lauroyl/myristoyl acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_2405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850576.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2368"/>
    <dbReference type="HOGENOM" id="CLU_049421_3_0_11"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG81295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="302" mass="33234" checksum="840661822391CEF4" modified="2014-06-11" version="1">MNARVTGAAYAAGWKLVRVLPERPVRALFEAGAARYARRGGPAPKRLAANLRRVVGPDADIEALTERAMRSYARYWHEAFRLPEWSEKDIEQRFVLENADVLDKAVAGGKGVVVALPHAANWDLAGAWATLHGIPVTTVAERLKPEDLYQRFLSFRRALGMEILPLTGGVRHPLDVLAERIREGRVVVLLADRDLSSRGVEVSFFGETTKMPAGPAILALRTGAPLFGLKAWNDGPVTRARVIGPLEVPDEPDAHRDTAQIAVVTQRIADALAEGIAEHPEDWHMLQPLWLADLPARKKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YPE7</accession>
    <name>A0A010YPE7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2232097_0_0_11"/>
    <dbReference type="OrthoDB" id="1746628at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="105" mass="11358" checksum="17FB8BBCFCB0124E" modified="2014-06-11" version="1">MVSVRMTYRPKPFFPAPLPGINEENLVRIRQCAGCRVRYAVFGEHRFCPACGPLPPEVVALDALGATSTARFGQRLTLTEADCRRAIADTTALCDAITALTAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQ54</accession>
    <name>A0A010YQ54_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852010.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3439"/>
    <dbReference type="HOGENOM" id="CLU_108054_2_1_11"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="12769" checksum="E743E5C21C2C5410" modified="2014-06-11" version="1">MTANGPARLVGISLDCPDSQRLAEFYLELLGGRQLWAKESSVGIEVPGAVLIAQQVDEYVPPAWPGSSIVHLDLTADDLGAAAERAVALGATLPVQPDPRWRVLLDPAGHPFCLTPFTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRL4</accession>
    <name>A0A010YRL4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382113_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="197" mass="22036" checksum="B25170F534BB8421" modified="2014-06-11" version="1">MSRNMPDFGVAAVATPEQLWDRLGESVKARINVRAGTILEWWASPGADRRPAVTVLGTNALIVAEPTMGADGRLANRLTTVPLDPASIQRARVVENPEPAPPHNRRRTEVIDLREYLPPQARELLEDPFSASAPESLRRVQYYVPVPERAILRIWYYLTDQRTLTFATGLGHGFRDATGADSWDITCWRATVRPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YW63</accession>
    <name>A0A010YW63_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane lipoprotein-sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.401"/>
    <dbReference type="HOGENOM" id="CLU_057675_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033434">
        <property type="entry name" value="MucB/RseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03888">
        <property type="entry name" value="MucB_RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MucB_RseB" evidence="2">
        <location>
            <begin position="134"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="394" mass="41676" checksum="C57463E6EBD03456" modified="2014-06-11" version="1">MSPRDSGAPPPERSPQDHHPEPEVLSGSSWNSGATVPPRRPLFVRRPALRWAFPAAVLVVALTIGGVSRFLTAADASPALPPRTAAQLLVDLQTAVPHPLSGTVVQKSDLGLPNFSGSGSQGSSDFTSMLTGTHTLRVWYGGEDKQRVALVGSLGESDVVRNGNDVWTWSSQKNEATHTRLTDEDLKKVQPSGTPLPSTPQEAADQALAAISPTTEVTTDGTAKVAGRAAYELVLKPKDRASRVGQVRLAIDADKKMPLRVQLYARDASKPAFEVGFTQVSFSAPDPAQFTFTPPPGATVNEQPVAAAEHPAIKDRLTVVGSGWTRVGILSGLGSSGSGDDRAKSMLDLLPKVSGSWGSGRLLESDLLCAVLTDDGRLVFGAVDPERLYEAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YWQ9</accession>
    <name>A0A010YWQ9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-superfamily subfamily IB hydrolase, TIGR01490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.620"/>
    <dbReference type="HOGENOM" id="CLU_027938_11_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="308"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="477" mass="50806" checksum="2E1E91C772D55FD0" modified="2014-06-11" version="1">MKLSDRLAAIAAGPQGPSVGAFFDLDGTLIDGYTAVSVYRDRIRKRDVGLRELGQTLGLALDMRLRGADLDALAAFAVGALAGRQEEDLEEWGERLFRQEIAGLVYPGARLLVEAHRRAGHRLVMATSATWFQACPVANDLEFDEVLCTRHGVRDGMLTGELDGGSLWGPAKARAVEGYAERADVSLLDSYAYSNGAEDVPFLALAGHPCALNPDGDLPAAARLHEWPILRLDPPGSRFSGGALVRTGVALGALLGSVGVSAGVGLLSRSRATAANLAGSIGPDLALTLAGVRVNVHGEENLWARRPAVFMFNHQSSLDLGVLGSLIRRDVTAVVKREARSDPRFAAIGALLDVAYVDRSAGRGRDALEPAVAKLRSGTSIAIAPEGTRSPTPRLGRFKKGGFHLAVEAGVPIVPIVIRNAGDLMWRDSLLVHPGTVDVAVLAPVETADWPVDEVDKLVDLVRAQFDSTLRNWPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXF4</accession>
    <name>A0A010YXF4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848633.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2205688_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="107" mass="11919" checksum="68A3AD3AE7213E31" modified="2014-06-11" version="1">MPEPELAWRLTQLARLLWTRRTAEYFRIRSEGTGETITKERAGIGRRDREYAAARDDLVAEGRSSDDRVHVSVRGMREWTVRIRPGTGNTPPPESEGLLGGGAIGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YXX1</accession>
    <name>A0A010YXX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloendopeptidase-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848831.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1094"/>
    <dbReference type="HOGENOM" id="CLU_029425_4_3_11"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458007" evidence="2">
        <location>
            <begin position="31"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="317"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="415" mass="44401" checksum="9C4929B68332EA62" modified="2014-06-11" version="1">MRVERGRVFAVCLVLALSGALLVESAGAHARNGPSPAEARRAMERAAAIMETATDRARAATQAFVETTQRLPGVQNRVAVAQGRVAAAQVRAASAERASARADRALRVAQAHFDAAQAAVEAAREQLGTYVRSTYQGRSYMVLSALGAGGGPGDLLDRLNYAERLVGGQSRAVDAVERRRQDLAEERATVAEQKRRADVARATARHALGEARAEQSAALTAQAEMESLLAQRRNAVHVAGQERQASVARYNEARAESYRIGQALREAARQVRGGTARTRGSRPRMLSRPGQLSMPVSGWKSSDFGWRFDPYYRRAQLHAGTDFAAPAGASIRAAADGVVVRAGWNGGYGNYTCIYHGGNLSTCYGHQSKILVWAGEQVSRGETIGLVGTTGASTGNHLHFEVRIDGNPVNPLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YY33</accession>
    <name>A0A010YY33_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848903.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1163"/>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="221" mass="23262" checksum="73E96E27D7FF9764" modified="2014-06-11" version="1">MVAVDDVTRVLIVDDDPLVRAGLTMILSGTDDLRVVGEASDGAEVPAAVGAYSPDVVLMDIRMPSVDGLAATEALRRRPDPPEVIVLTTFDADEYVLRALRAGAGGFLLKDTPPAEIVRAIRTVAAGDPMLSPAVTRQLIAHVSEAGVDARKSRAVALLAQLSPRELEVAEAVGRGASNAEIATSLFMSLATVKAHVSRILTRLELNNRVQLALLAHDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ22</accession>
    <name>A0A010YZ22_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="17" type="ORF">CryarDRAFT_1547</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849378.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1521"/>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_11"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="262"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="441"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EXG80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="641" mass="68786" checksum="B653357944CE0B43" modified="2014-06-11" version="1">MAGRIRDSDIALVRERSPIVDVVGERVTLRPAGGGTFKGLCPFHDEKTPSFNINPAKGVYYCYGCAEGGDVLSFVMKTEMLTFSEAVERMAARAGIQLTYTEAGPAPVRNTGQRQRLIAAHTAAAEFYAEQLGTRDAMPAREFLAARGFGPDAARQFGCGFAPAGWDALTKHLRGRGFTNEELVTGGISKAARSGSLIDRFRGRLVWPIRDLGGEVIGFGARRLLDGDDGPKYLNTPESPIYKKSHVLYGVANAKKDIAKQQRAVVVEGYTDVMACHLAGVVTAVATCGTAFGADHIQVLRRLLMDQDEFRGEVIFTFDGDAAGQKAAVRAFEDDQRFVAQTFIAVSPQNMDPCELRLAHGDSAVRDLVARREPLVAFVLRTLLAKYDLDTVEGRVAALRAAAPLVARIKDRALRPEYARKLAGDLGMDLEPVLKAVNEAAGKGGGKGGGGRNAAPNGRAPRQGGAPEAEDDAPVSPAGGRPDPADRALMVEREAIKLAVQEPVLAGPLFDAVGEDAYTNPAYRSVRRAVAVVGGAVVGTSGPEWVQALIDACDDLVGKALIVELAVERLFNDGEIDPRYVSAQINEVQRLATVRRVVAVKSKLQRVNPVDAVDEYMKLFGELVALEQYLHGLREQAIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ32</accession>
    <name>A0A010YZ32_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849391.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1530"/>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="397" mass="40895" checksum="E5EBCA6B76CD5182" modified="2014-06-11" version="1">MTPRPRPDNSAQSQILLTLRNEGPASRAELGDRLELPRARLAAELTRLNELGLARDGGPAASRGGRRSTMVELDPDLRFIGVDLGVTSVTVEVTDGSLEPVASIEEPIDIRRGPEAVLDRIDDLVEKARVDGHLPRLAGIGLGVPGPVSFRDGVPVSPPIMPGWDRYPVREELAGRHGCPVVVDNDVNIMVVGERGGGVARSIEDLLFVKVGTGIGCGIVVGGQVYRGVDGCAGDIGHIQVDPHGPVCACGNAGCLEAMFGGAALARDALAAARSDTSPALAERLRLNGTVTAADVGAGATEGDPVCIGLIRDGGRRLGGVLASLVSFFNPSMIVIGGGLAGLGHLLLAEVRSVIYRRSLPLATRNLPVVLSELGARAGVAGAATLASDLAYGSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZ65</accession>
    <name>A0A010YZ65_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849451.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1570"/>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_11"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="311" mass="31753" checksum="817DF02CB763FCEC" modified="2014-06-11" version="1">MRIGCVGVHVLDHLVIGIESIPEHGGGQLVETIRLSAAGTAGGTALVAARLGAEVRSIGVIGTDALGDTLLALLARDGVDTGGLVRTDGHQTSASVLPIRPGGDRPAWHCIGANGAFTIDDVRDEQLHDLTHLHLGGPEFLGGDAAARLLRRAHERGTTTSVDVLAPGDPGLLAWIAAALPYTDYLLPNDEQVRGFTGATDLVDGARALVERGAACVAVTRGARGALVVTDDQVVDVPAYATRVVDTSGCGDAFSAGFLRGRSLGFDLRGSAELGCATAAQVAGGLGTDAGTYTLDDVLAFAATADRLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YZK7</accession>
    <name>A0A010YZK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme F390 synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849620.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1697"/>
    <dbReference type="HOGENOM" id="CLU_535023_0_0_11"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="427" mass="46691" checksum="14876D39F5F64E37" modified="2014-06-11" version="1">MRLDPVALFHDAARNVPAYRHFLAERGVDTASIRTLLDYAALPVVTKENYVRAYPLPERCRGGSLDGCDTVALSSGSSGQPTVWPRRLVDELAATERFAEIFRTFGADEHRTLAVICFPLGNWVGGMFTAAACRHLATQGFRLTVATPGNVVDEILRVVDALGPLYEQVVLLGYPPFVKNVVDRGSGWPDRRLKLVFAGEVFSERWRDLVAGRAGIADPVTHTAALYGTADAGVLGIETPSSVRLRRELSSTTFAGGRLPTLVEYDPGHRYFETDGDALLFTADGAVPLIRYDIGDEGGILPGNLVYVFGRRLFAVSLYGANVYPENVAEALEADDVVGWTTGRFVLRTPESDDGDRYLDVTVELAPGHGGEGRENRVAEAIRAYLPGVNSEFAHYVPAARQLPTVRFRPIGDPDNFPLGVKHRYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0F5</accession>
    <name>A0A010Z0F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative extracellular nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1993"/>
    <dbReference type="HOGENOM" id="CLU_003608_1_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="847" mass="88006" checksum="A4F075443C861E08" modified="2014-06-11" version="1">MTRRPQRHARRNEFTKLSFYLPTAFPVLLLAIALGATATSSTVGTASRPADLVISQIYGGGGESGSIWTADFIELTNRGDEPVNLRGWSVQYAPPRERGWGVTELSGSIPAGGRYLIAQAGGPNGTTHLPKADVTGSLDLGSTSGKVALVHAVETLHCVASCTTVEGVRDFVGYGNADDAEGRPAPALSNTTSIVRRDISVPADQGTSSIEDDPGGPAGVENAKQQERGVPGVDGSGGVDSGSNSADFVVATPAPPGGAGDKAGRTARIADIQGRSHTSPLAGRLVTSVPGVVTAVGRTGFWMQDPEPDDDPATSDGLFVYTGNAPRVQSGDTVRVAGTVTEYRPGAAAGADNLTTTELIRPTVSVVSSAARRPVPVLIGPGGRMPPTQIRTDAPGDVESTRLFAPTLNALDFYESLEGMLVRLNNPTVVGPTSVDGQLPVLPAGAGSSRTTHGGLRLTDTDPNTERIVLDDLLAPLPVANVGDQLPGALDGVLDYGAGDYRVELLSTPVVRAGKAKPETARAPKPDELTVSSIDISGADPNGGRGRLKQLAATVVRGLRAPDVLVVEEMPDDDGATYDAEVGADEGWAALLDAIRAAGGPRYEVRQIDPVSRRDGSGAENRRIGFLFNPARVSFVDRGAGDATTATEVDTRDGEVGLTLSPGRVAPAATAFRDARKSLAGEFRFRGRTVFVIGNDFASGRGDGPLYGRQQPRRHTSEQQRGSQASAVRTFVDELLDADRDAAVVVVGGIADTDGSPTLGLLTDGGTLADVATKLPAADRYSVVSEGNAFLLDHVLVTPALSGAEVDVVHAQSDFASRWTDRDPLVGYLRMPKGPEDSPEDSSPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0N8</accession>
    <name>A0A010Z0N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2082"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="430" mass="47861" checksum="B250EC0287A80968" modified="2014-06-11" version="1">MKHSMDLGMFRQGNHSPSYATLSRSMGAGAEDLSDFCIPCNPYFPTPEMFAELASKLETMLKYYPTDAGAITGQLASLLQMPPQTIAMGNGSTELITWIDHLLITESMATPVPTFGRWTDQSLETGKRVDMFQLPEAGGFALDIDAYIEFIRERGSRVAVVCNPNNPDGNYIPKWEVLRFVDSLADRDLVVVDESFIDFVDAEHRPSIAQEAMLRNNVVVLKSLGKNFGLHGIRFGYVVGNPALVKKIGSRLPKWNLNSLAESVVFMLRDHLGEYRESLRLLARDRYEMINELRRIPGMQVFPSQGNFVLVKLPAEVEGPRLRDYLLQRHGVLIRECGNKLGITSQFVRLVVRPRADTERLLTGIRSYLTSSFSESLDGATPMDLAGRFAQPSGVQTGTHQLIDDDPLGDRVVPLMGSDPLGGPRMARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z0X6</accession>
    <name>A0A010Z0X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850260.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2154"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_11"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="345" mass="36254" checksum="144DFAF1E8A75702" modified="2014-06-11" version="1">MRTTTGWHVEGAASPLRRGRVERRDLRPDDIAVRIDYCGVCHTDLHARRGHAGTTPLVPGHEFTGVVTEVGPDVTAFAVGDPVAVGNIVDSCGECAMCRAGQENFCRAFPTLTYGGTDRHDGSTTLGGYSREYVVREAFAYPLPPGLDPAAAAPLLCAGVTVWEPLRALGVGPDTRVAVAGLGGLGHLAVKLAVALGATTSVISRSPDKEADARRLGARGVVVSSDPARLEAARDSFDVVIDTIAAPHDRGPYLRLVAMDGTLCSLGDLGPVTVETMDLLVGRKKLSSAGSGGRPATAEMLRFCAQAGVAADVEVLPSARVNEAFDRLARGDVRYRFVLDLSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z137</accession>
    <name>A0A010Z137_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2218"/>
    <dbReference type="HOGENOM" id="CLU_000445_100_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="288" mass="31441" checksum="5AB70C06A571E949" modified="2014-06-11" version="1">MNYRTHVGLDEISRRLGDIAPTATTDVPALGVRVHVATDVAPPAPVIFEPMLYLVFQGAKRILLSDREISYGPGELVTTAAHIPALAEVVAASDRFPYRALEIPFDQQLVTALIAELGELPSSPAESVAVNPLPRSVLDPVSRLLELAHDPDAARVLAAGVKREIWYRILTGPNGGAFVELTRTHSALGLVHELTQWMHEHLHEPLDVGRAATHANMSVTSLYRLFKAATGTSPGSYHKRLRLMEARRRVVERSDTVGRIAAAVGYASPSQFTRDYRRAFGTSPTADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z1H7</accession>
    <name>A0A010Z1H7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850516.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2326"/>
    <dbReference type="HOGENOM" id="CLU_069543_5_0_11"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="224" mass="24102" checksum="55D68DA49D4051EF" modified="2014-06-11" version="1">MFVTIMFMPPRRTPVSRRDRPAKPPLSRDGVVAVALGILREEGLERVTMRRLAAELDTGPASLYVYVQNMAELHGALLDALLADFPLTASDPVDLLVDYTTLLLEYPSLARSVLTLWPSGPNYLRVIDALLGRLAAAGIAPRPAAWGVDILLQHATASAAEHGTRRESPVADGEWEGLRAAVRDAPDATYPHIAAHRDALVSGAGEQRLRWAFAALVNGIAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2T3</accession>
    <name>A0A010Z2T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_2852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2814"/>
    <dbReference type="HOGENOM" id="CLU_006850_5_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG81733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1155" mass="120948" checksum="56CE0D16CEB3695D" modified="2014-06-11" version="1">MLRFGVLGPLLALGPAGPLDVKGPRHRAVLARLLVARGRMVTVDRLIDDLWGTAAPDGAVGAVQTFVAALRRALEPERAPRAPARVLVTSGPGYALRVDPDAVDALRFERAVTGSRDLLPAAALASLESALGEWRGPAYADFADAPWARAEATRLDELRLLAVERRADALLGLDRPAEAVPDLEAQVGAHPGREGAWRLYALALYRAGRQSDALAALRRARRILADSAGLDPGPGLRRLEADILAQSESLHLPAPAGSAERRPAEPVERRPAEPVERRPAEPAERRRAGSPPAERGPGPASAERGPGPAFAERGPEAAPSGGRGPVRIPVPPGSATGLVGRAEESAQLAAVAADVRARRLLRLALVSGEAGAGKSALVSTFAAGLAAAGWTTAWGTNPDDRARPDLEAWTQLLETVPGSAADPGLSRFERHRAVAARLENAARAAPLLVVVDDLQWAGTETLALLAAVVTEPPAGPVLVLATHRSTDVPPALTETLGRVARTEPARLYLRGLPAAEIPAVVRATIGRDVDAGTAATIHRRSGGNPFFVRELARLVADDGDLAAVPPGVRDVVRYRVAALPEPAQAVLRRAAVLGPDLDPALHTVLAGDADTVLDAVDAATAAGFLVERGPRRFTFAHALVRDALAGDVSAARRASWHAAAAAALETLRPDDVEALATHYVLADDPATAGRAVHYARGAAERAERRAAPADALRYWNAALEAFDKQPAALPTQPGATVPTQPAATVPTEPAATVPTLPAAAGPARAAAAVRTRLDLIMGTVRALALTGRLAAARTRRAEAVELAGTIGDPVLTAHVIGAFDAPALWPDADDPVLARHLAQVTERTLTALPAGRSADRSRLLATLALELRSAGGARAAAAAREAEQLARELGDPGVLAFALNARFMHSFGRAGLAPERARIGAELVALSERAELRAFEILGHLVLLQARSALADLTAADAHADTVDRLGERYQSPLVSVFTDWYRAMRASLGGRTAESASRYRAAAAHLGGPEMPGLDRGIAPLARFCEAVRRGEPLAEFASGDFGAFEPWVRPLLPGRGGTPEVPESPRDLLYEARTVLHALLAVRTGDRALMLRLHDALLPARDELAGAGSGMLTLAPVAHYLGDLAAALDRPDEAAAHHRHAARVFARASGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z2V6</accession>
    <name>A0A010Z2V6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2825"/>
    <dbReference type="HOGENOM" id="CLU_088572_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041484">
        <property type="entry name" value="TetR_C_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17933">
        <property type="entry name" value="TetR_C_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="213" mass="23147" checksum="B9DA81B0F3710E1D" modified="2014-06-11" version="1">MPDPDDLTARARIRQAALTQFADVGFQKATIRSIAAEAGVSPGLLRHHFGSKEALRDAVDAYVMDEIRRTNDDVTAASATGTFGASVDREALRPFQRYLARALLDGSSTIATMFDQLAAMTTQWVAAADETRTDRPGTDTHTRGALYTAMVLGIPLLHEHLSRVLGVDILSDDGDRRVALAMLEIYSHPLISTELAEQARAALYPDPPSRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z3H3</accession>
    <name>A0A010Z3H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851474.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2648399_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458934" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="76" mass="8249" checksum="648E4B8D1BA7D0C8" modified="2014-06-11" version="1">MTRTRLTLRRLATALGLTRATADDQPEPPTQVVAVLVPSGAGFRLRATPDVRVPDGAGRIYRTPDGRIALDWHEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z423</accession>
    <name>A0A010Z423_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="56">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="56" type="ORF">CryarDRAFT_3280</name>
    </gene>
    <organism evidence="56 57">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="56 57" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="56 57">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="52">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="51">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="31">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:14993"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:14994"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="56">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570346.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3237"/>
    <dbReference type="HOGENOM" id="CLU_223085_0_0_11"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047117">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016295">
        <property type="term" value="F:myristoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004320">
        <property type="term" value="F:oleoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016296">
        <property type="term" value="F:palmitoyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="3 53" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="57" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="55">
        <location>
            <begin position="1922"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="55">
        <location>
            <begin position="3899"/>
            <end position="3974"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="55">
        <location>
            <begin position="5591"/>
            <end position="5666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="54">
        <location>
            <begin position="4944"/>
            <end position="4983"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="53">
        <location>
            <position position="1957"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="53">
        <location>
            <position position="3934"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="53">
        <location>
            <position position="5626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00023387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00023389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00023390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00023396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00023397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00023403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00023410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00023413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00023414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00023416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00023418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00023419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00023420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="55">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="56">
        <source>
            <dbReference type="EMBL" id="EXG82138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="57">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="5952" mass="616665" checksum="4B66AC2D3BF6588E" modified="2014-06-11" version="1">[encoded data, 5952 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4Y4</accession>
    <name>A0A010Z4Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3097921_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="51" mass="5233" checksum="A030D8108957B421" modified="2014-06-11" version="1">MTAPSGPVFLGDPDAMGDPDRRDPGIGIGIGLTDAERLLGLPRGSDRRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5F7</accession>
    <name>A0A010Z5F7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852453.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3737"/>
    <dbReference type="HOGENOM" id="CLU_007383_5_2_11"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="247" mass="25810" checksum="0B39159E404E4310" modified="2014-06-11" version="1">MKVVVIGGTGLIGSTLVGELAEHGHEAVAAAPSTGVNTVTGEGLDPVLEGAAVVVDVSNAPSFADDAAMDFFRTATTNLLESSAKAGVEHYVALSVVGTDRLQESGYFRAKAAQETLIRESGLPYSLVHATQFFEFIAAIADFSTVDGTVRLPSARFQPMAAADVAAGVGRTAVEAPVNGIREIGGPEQSGLDALVRRALAAKGDPREVVTDEQAPYFGIRVSERTLLPGTDARLGAIRFDEWLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5L7</accession>
    <name>A0A010Z5L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570617.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3807"/>
    <dbReference type="HOGENOM" id="CLU_051214_2_0_11"/>
    <dbReference type="OrthoDB" id="1327691at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458082" description="Glyco_hydro_114 domain-containing protein" evidence="1">
        <location>
            <begin position="43"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="57"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="333" mass="35901" checksum="7E20099F950351F3" modified="2014-06-11" version="1">MHANHGRRDRRPVFRRAAMLFAALAVVAAGCADVAGDTPASAATRAAAVKTFLPNAKFDYQISTGYTPASGVKVVSRDVKDTPAGLGYDICYINGFQTQPDEKGSDGQPLEGTSKWFADDASRKQLLLPNPTPDYPTATENQQYSKPYYVDPGWPDEIIFDLRTDAKRAALAAIVGKQIQACADKKFDAVEVDNLDSFTRAYSNLSDRKLAREGKEPKEGAPRLMSKSDALAFATLLIQKAHGLNLAIAQKNTAELADEGKAAGFDLAVVEECGSTSECGDYAEVWGGNWVDIEYSASGFSKACTAVKSKISVVQRDKNVTKPGTDGYVYNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5N2</accession>
    <name>A0A010Z5N2_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852585.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="9acto-a0a010z5n2">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3820"/>
    <dbReference type="HOGENOM" id="CLU_006586_16_0_11"/>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="465" mass="47893" checksum="671DA445986DA1E0" modified="2014-06-11" version="1">MHPIVETPAGVVRGRRDAAGERYRAIPYAAAPTGAGRFGPPVPHPGWSGVRDGTRPSPTAPQPVRNFGRLDLAPYFGPGWVRGDEYLTVDVHTPAADAGRRPVVVFVHGGGFVTGSGRAALYDGRAFARDGVVLVTLNYRLGVPGFLHLDGAPANRGLLDVLAALGWVRDTVAAFGGDPANVTLVGQSAGATIVGALLATREAKGLFRRAIVQSGSGTGAFTPEQARRVTAAAAAALDVEPTVSAFGAVPDERFVDVLPALSGLDLRTGTATDPLVGLSPFSLVLDTQPADALADGPAADVDLVIGTNREEGHLYLVPQGRFETSTDADVAALAARVGADAPAPEGSTPGERRSAVLGRALFGAGTARMTDAHARISGGRTYAYSFGHRSGALGGRLGATHTVELPFVFDVADEPWLHGDTGLLGPGPAPAGLAARMHGAWVAFARTGDPGWPPYAPGRPVTETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKU7</accession>
    <name>A0A010ZKU7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183438_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="234" mass="25669" checksum="6835D84CD89F1873" modified="2014-06-11" version="1">MPDELSVEQLAEHCGVTVRLVRAHQSRRLLHPPRRVGRRSVYDHSHIDRVALIQRLQKAGFSLAAIRALLQTGHNAPELALAWHAEGLAMRFPTLTDDSDPELQVEPEGVADLHAQPGAWEALQSYGLVTRGPDGNWHGTHPVLVAVGRRAREMGMPSTEITRLQLQVARAAFDLSREILDSFNRIFAQRPAGNGRIEHYAGMSAVATALVTATFEVQLSRVVRGVVGIPSDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZLU9</accession>
    <name>A0A010ZLU9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_0675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848395.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.661"/>
    <dbReference type="HOGENOM" id="CLU_069543_3_0_11"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="211" mass="22747" checksum="89DFECC1E132E1E4" modified="2014-06-11" version="1">MARPSSPLLTRDRIRTAALAMIDRDGLDGLSMRRLAAELGVRAASLYGYLATKDELLTDLADDVLAGVDTSGFSAGWRTGLTVWARSYREALAAHPNLVPFLAHSPGRRPQALMHADAVHGGLTNAGWPPRYATMIGASTKYLVVGAAMTSFSGGFADDVEVYVGRYPNLSQAHLLAGHEEIDRDSFELALTAFLDGLSRLHEQVVRSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMP9</accession>
    <name>A0A010ZMP9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Matrixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569763.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843902_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458003" evidence="1">
        <location>
            <begin position="39"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M10" evidence="2">
        <location>
            <begin position="249"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="330" mass="33500" checksum="3845E44C37D6031A" modified="2014-06-11" version="1">MRNLLTLRSSAPTISVAALVATAAVTAGIATAPATTTAAPTGPKLVAADAETDLTTVTTAGDTIRYQGLTVRIPAVGEGVQAAAQSTSGDISITVSRSDDGSLAVKTDAHVHGQAAEEEHGEAQAVNATAIRPAAAKTCKDAAYALSGWKLPSFKWYYNPAGAPGSVRSSAVAAIAAGTTGLTKACGQKSLKLVPSYGGSTSAGVQVGAAGNCTGNDGRNVIGWRAGTGKWLGMTCTYFKTIKGKKTVTGTDTALNTQYKFFTATKNCSNAYDLQSVVLHERGHSLGLNHVSQASHASAVMTPALSACSVGKRTLGLGDYKGLAAMYGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMR1</accession>
    <name>A0A010ZMR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1006"/>
    <dbReference type="HOGENOM" id="CLU_161236_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="127" mass="13424" checksum="5D2F9B74B9F58FBF" modified="2014-06-11" version="1">MIPAQVDRFRLSVGRLTTLLSYWTPPRFSAAASPLVGDAVSALCATSGSALEEGVSVAERLHVVVQVLADLGADAEGQPRRAVPRMVEPGTLVDQLTVLGDDYVAADPDVEELDRVTRGLDALRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMX8</accession>
    <name>A0A010ZMX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp pilus assembly protein TadG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1086"/>
    <dbReference type="HOGENOM" id="CLU_996453_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="279" mass="29242" checksum="CD99BBDADA26F93B" modified="2014-06-11" version="1">MFRVLAVFCAVAVFRVRAAVGVFQVFRVPEVVGVLRALAVLCRPSVCWVFRVVRLLWVVWALWVARVFPVARVFSVARVFSAPRMLFMACAQSNARRATPATPATPVAPVAPVAPVAPVAPVAPVAPVAPVAPVARVARVARVARGTPAARGDGGSAVVEFALVSVVLLMLLLGVLQVAVYLYVRNIAAACAAEGARFAANADIDVAQGAERAEEILQHGAGSSVAERITCIGRDELGDGGLRLVAVECTGALPVFFAPVGDTLPLRVTAHAVEESRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNE6</accession>
    <name>A0A010ZNE6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1251"/>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="52"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="47798" checksum="0C10231DA9F09E10" modified="2014-06-11" version="1">MLDVVIRARRVVTATGEVDRAIGVAGGRIAAIEPFDADLSAAEEHTLPDEHVLLPGVVDTHVHVNEPGRTEWEGFATATRAAIAGGVTTIVDMPLNSIPPTTDAAALEVKRKAATGQVYCDVGFWGGVVPGNGPDRRGLHDNGVFGFKCFLLHSGVDEFPPVDAAQLEEALKALHSFDALLIVHAEDSQAIDRAPTAHGERYADFLASRPRGAENVAIAQVIELARWTGARVHILHLSSSDALPMLESARRDGVRITAETCPHYLSFTAEAVPDGATQYKCCPPIREASNRELLWEGLRRGVIDCVVSDHSPCTPDLKRFDIGDFGVAWGGIASVEVGLSAIWSEARARGFTLADVARWMSQRPAEIAGLRHKGRIALGYDADFAVFEPDAGRVIDPERLHHKHPVTPYAFRPLAGLVRETWLRGQRVSGDEPTGQLLARGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNN2</accession>
    <name>A0A010ZNN2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073799_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="35873" checksum="F1C8FF4E8C98DE67" modified="2014-06-11" version="1">MTNLGSIGLSESDFPLHFRIVNVLPATLVTITPACLLLSGAPTQSPSLDLLLDRARNYGWVGAVGATIFIAIASLLLQPLEFASVRFMEGYWSRSGFMGGAAELGSWIQRRRRGRHKWISRSTLPPGMVEDSRQRLREDWPFSGEVRPTALGNRMLAFESKAGFGLGIEAIAFWSRLYYVLPEPALKIIDSHRDQLDFACRICMALALCSCSSLALLLQYPIWMLVPALFAAGSWAAYRASLAAAANYGVVVTSAIDVFRLRLIKEMGLALPVDTDAERSIHENLTQLWSGGLNSKKIKLTNAITDQDFGIRVDHRQASTSDEDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNN6</accession>
    <name>A0A010ZNN6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133101_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="121" mass="13074" checksum="4F283DFB52FBCD9D" modified="2014-06-11" version="1">MARETRGLVQGGRSGRAEEWLDPEAPGEDQPEADFAPDATLVGGIPEGLTPEGVAERSELASYLGRAVYPAYRDQIIDRLVENNAPTRLVTVVRDLPADAQYENAGSIAQALGLGHEEQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZPR6</accession>
    <name>A0A010ZPR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849666.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079072_0_0_11"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="283" mass="29827" checksum="8911D64EA5FF4DC1" modified="2014-06-11" version="1">MIGVWLAPAPFLTSTIAEQRTAFARIEELGYHSLWTGEPAPAAATVAPAREIFSHHAIALAATDRLVVGSGIANVAARGPATMRGAAATLAEAFPGRYVLGLGGAAGPSALRAYLDEFDAVPLLPDVRYPRVLAALGPKALGLAAERADGVHPFLQPVAHTRVARDAVGPGALVVPHQAAVLETDPDAARARLRAVFGRMPAADNPYVRSYRRLGYGDDDLVAGYSDRLVDDLLAWGDEAAIAARLHAHREAGADEVLVQPFAESLSDVLRVLERLAGELFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQL2</accession>
    <name>A0A010ZQL2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein, CobQ/MinD/ParA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.529"/>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="1288" mass="144373" checksum="629308D20F138662" modified="2014-06-11" version="1">MCMANIAWILASRGKRVLAVDWDLESPGLHKYLEPFLLDKELRNSDGVIDIFRNYALEAIDSNAPDIEPLRSKYADISEDSVTLWDTPFDPPNLFRFLPAGKQNSAYAQAVGTFNWDAFYNSAEGLSFFEELRRNFKSDEYDYVLIDSRTGFSDNADICTLLLPDIVVVGYAMNDQAIQGGAWAAQHIVESAEREVGRRIKVLPVAMRVDPVEQARLKQSRAFARAAFQSVVDRLDLDDPERYWAETQIPYKSNYAFEELLAPIEEPASELEGLLVPYQRLAAIITEGEVTEAHPMKESTRQALQGRYARVPIGAPQTAFVAYAPRDRAWADWIRTVLYLNGIRVVERRAGQKPGDPIPDVDRVVALISSHWESSLDARALSIRASEKHAESKILAIRIDEGSTLPPWSEIPGLNLIGFGPDDARKALLAHLDRHSPADRLPHDSAARYPRTRPSVIELPPNLDRFVGRDDVLEELRNKLAPGTTPDGPVALVGLSGTGKSQTALEFALRFQADYDVIWWVPAISRISVETSLRDLDAAVAAANESEQSVPESASSNGTTPAESGEHPPRRVLLIFDSADTPDAIIDLLPKRVSVHSIVTSKDTGAWASVNASTIALERFTRPESVQLLKFRAPWTTDREADRVADALGDFPVAIEHAARWLNPRRDTPSAVNDYLRLLAEWRNRMRADADQPDEFLPAAVSWRLSIENLASEYPAAALFLEYCSFLSPNAIALALLERGQVLAELEAADPGLRDFGTGKILRVLRGHGLARQDFTRRTIFIHPLMQAAARSRLTAEERENRRAAILDALARFAPPDTEAEEVHHDATYDELQDHITPSGALRSDRWEIRRWLVNQVRYLWRTGRWEEACGLGERLLDTWSPPAPAGHENRFERWISLSDDERVDGNQQELAKLRLRMGVQVANAYRSEGRYRDSYELDRKILAVQSGLLGGPQHPQMLMTLRSFGADLRGLGRFREGWEDDQATYAYFRELFGVDHPDTLSAANNLAEALLLIGSAEESLQQDRDTYDRRRRVLGDGHRHTWFSYGNIGTVYRELDRVAESMRTLRDTAEECRKRFGDDAPETLRARRSLAVSWRRLGDPELARSLSQATVRRYTARYGLNNPDTLSCRLNLATDLHVLGDYEAAVAMGADVLEGYREVFGDNHPFTFICQCSLATFRRATGDFARSGIDAEASWNGLYASLGDRHPILAGASINYANVLVDLGDFTRAKELDSHARSAFTRLYGNGHSYSEIALRNHLDSQEREEGGAIDRPTSDRGEIDLEVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZR03</accession>
    <name>A0A010ZR03_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Panthothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848406.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_2_1_11"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="2">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21915" checksum="0AE82592534CBD71" modified="2014-06-11" version="1">MIPSDLIDRARELAAGPRRVLGLTGAPGAGKSTLAAELVAALGPRAVLVPMDGFHLANAELIRLGRRDRKGAVDTFDAAGFAALLRRLRDPADELVYAPYFAREIEEPIACSLPVPADVPLVVTEGNYLLVDEGPWAAVRGLLDEVWYLEVDEDVRLERLVARHIAFGKEPAAARAWSHGTDQRNADLIASTRAHADRVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRJ6</accession>
    <name>A0A010ZRJ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding domain-containing protein, AraC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569722.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.862"/>
    <dbReference type="HOGENOM" id="CLU_047930_1_0_11"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="220"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="328" mass="35993" checksum="966E887ECD60B915" modified="2014-06-11" version="1">MGTSVNVERDTFDSRDMAEVQELISRRYVEHEPRISGDARAFRFTSRSVRAGALTLDRAKYQANIVINADPFDTTLVLRVREGRFDISSGRARVVAGPGECVLYPRHVPLDFVMDEVAYEVIQMPGELTTRAAARLGVDPAEFRFEGMTPVSAAMTRHWRATTAYITGVFNGSEPLEVHPLLLSAVMEAATTAVLAAFPNTTMRIDYVPGSGWSGPSVVRRAVEFIEEHAAEPVTLESIAAAVGVSTRSLQAAFARHLDTTPLGQLYRVRLNRVREELQNAQPGDGSTVADAARRWGFADRSRFAAAYHAAFGELPSQTLRQGRTIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRY3</accession>
    <name>A0A010ZRY3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1013"/>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="286"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG79977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="410" mass="42861" checksum="6629C0E876963ACF" modified="2014-06-11" version="1">MPEFADRDAVIVATARSPIGRAMKGSLKDVRPDDLAATIVRAALDKVPSLDPTTIDDLILGCGLPGGEQGYNMARVVAILLGYDTLPGTTVTRYCSSSVQSTRMAFHAIKAGEGDAFISAGVETVSRFVKGSSDGLPDTTNPLFLDARKRTDDSAAGGVTWHDPRNDDTLPDVYIAMGQTAENLAQLKGVSRREQDEFAVRSQNLAEKAIANGHFAREITPITLPDGTVVSTDDGPRAGTTYEKVAGLKPVFRPDGTVTAGNACPLNDGAAAVVIVSGARARELGLTPLARIVSTGVTGLSPEIMGYGPVEASKQALSRAGLAISDIDLVEINEAFAAQVIPSYQDLGIDLDKLNVSGGAIALGHPFGMTGARITTTLLNNLQAHDKQFGLETMCVGGGQGMALVLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTA8</accession>
    <name>A0A010ZTA8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569887.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1500"/>
    <dbReference type="HOGENOM" id="CLU_127577_1_0_11"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="123" mass="13242" checksum="4E00500B7AE5F4B4" modified="2014-06-11" version="1">MLVISRFDVPEADGEGFLERARAALAAFAARPGFVRGRIGRSADVPTAWALTTEWESVGSFRRALSDFDVKVHASTLLAESSDEPSAFEVMGSWDGPVETAGRTDRALDADTTRVGDRPVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZTQ5</accession>
    <name>A0A010ZTQ5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849557.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1647"/>
    <dbReference type="HOGENOM" id="CLU_047250_1_0_11"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="138"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="398" mass="42845" checksum="19BAC503C73CC5D9" modified="2014-06-11" version="1">MTTWPPHRREVRPWRQSQRGGPKADRILSEVTVSLPPDIAGLPVVNALPASAIAQGEDALREIAALDQAHGEDLGALGVLLLRTESVASSKIESVEASLDDYARALHGSRANASATSMVAATSALGALLTETDGRKRIDADSLLAAHAALLADDPAERDYAGRWRDMQNWIGGSDHSPRNALFVPPPPDLVESYVDDLLRFANRDDLPTLAQAAISHAQFESIHPFTDGNGRIGRALINAILRRRRATTRVVVPLASALVARRERYFDHLGAYRDGDVEPIVRDFALASRIAAAESRTTAQRLTEIPLEWADAVGRVRAGSAAAKLLAILPARPVVTADDVAVATGAPLSSVYAAIERLDTAGVLRPLTNRKRDQIWGATLILEELDELGARIARAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU40</accession>
    <name>A0A010ZU40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase involved in chromosome partitioning</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849749.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1774"/>
    <dbReference type="HOGENOM" id="CLU_060965_1_0_11"/>
    <dbReference type="OrthoDB" id="1350399at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="272" mass="28312" checksum="CFA2FB6C99941F8E" modified="2014-06-11" version="1">MALIALASAKGSPGVTTAGLACVFSWAARTVLAECDPSGGSVLAGYLQGQIDGGRGLMPLAVADLRHSGANDRLESEFWAQLVDLAPPARQRLLLAGLTDPAQSGTLAPLWNRFAGFFARLEFSDPSFDVIVDCGRLAAPATPWPLLWAADAVLLVVRPTLPSVSAAMPTLSAIRAQLNERTASLSSLGLVVTGAGPYSASEVSNQLGAPVVATLPDDRRTADVLAFGGDVRFSRPLLRAAAGAETRVRALIADHREQVPRRAVRRAVGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZU69</accession>
    <name>A0A010ZU69_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851899.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3348"/>
    <dbReference type="HOGENOM" id="CLU_036879_0_2_11"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="326" mass="34357" checksum="F124585C86661678" modified="2014-06-11" version="1">MRRYVLRRLGQAAVVLLAAYTVSFLILDLLPGDPVSAMAAGGLDGNPIDPAQLAALRHEYGFDQPVYLQYLDYLGRAVRGDFGNSVATGRPVTTTIAEALPQTLQLTGAALLIAVLAGGGIAILATYSRRRWLRQVLLSLPPLGVSVPTFWIGLMLVQLFSFRIHAFPAFGNDGLRGLVLPAVTLAVPTAAQLAQVLAKSLSTTLGEPYIETAKAKGAGRLRIHFRHALRNAALPTLTLAGLLVGNLVAGSVVVESVFARNGLGRATIQAVTVQDIPVVQAIVVFGALVFVTVNLAVDLAYPVLDPRIVLSGPPRPTAPLQVGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUJ2</accession>
    <name>A0A010ZUJ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="16582" checksum="B53354D3E31D045B" modified="2014-06-11" version="1">MERWRRGAFLLCRDWHAADDVVSVTVGRIFEKWRKVAAADNPDAYARRMLARAWADECRRSWRRELPSDDLPDGALPADHRIEDQQSLAELLDSLGPRQRAVVVLRFYFSLSVEETAEALAISSGTVKSQSARALTTLRSLANSPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUR1</accession>
    <name>A0A010ZUR1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852237.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3578"/>
    <dbReference type="HOGENOM" id="CLU_067676_7_1_11"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="217" mass="23038" checksum="417743AE1787BB32" modified="2014-06-11" version="1">MTTTLTHPSVRRVLDRLFAAAAHDDEQVTDLADPRAFLAAPDHERAESRAEVYMPISAAGGDLLYALARSARPTTVVEFGTSFGISTIYLAAAVADNGTGHVYGSELSTTKLAAARDNLTEAGVADQVTLLPGDARQTLRDVPGPIGLVLLDGWKDACLDVLRALEPRLAPGALVVADDTTFDSMADYLRYVRSPANGYVSVAFPVEDGMEISCRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZUW5</accession>
    <name>A0A010ZUW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569993.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2061"/>
    <dbReference type="HOGENOM" id="CLU_031028_0_0_11"/>
    <dbReference type="OrthoDB" id="226222at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="594" mass="64576" checksum="E9394BE6B392E478" modified="2014-06-11" version="1">MTAAPEIAGIDRGTLPWVGRVLGTEDATPLQFHVALREDAYLQLDDVVVTVRDVPGLGPVLTAGVVTQVTARHEGAQFSSDVFLIADGVLPAQVQEVAEIATTRVEPEVYVPPRPGEPVRRATGEERAIALYFDRMERKVPVGLGRDGTPIYVNLDFLDGTRGAHISISGVSGVATKTSFALFLLYGLFRSGALGRRAVNTKALIFSVKGEDLLFLDHTNTKLDERLRQQYAIMGLPAEPFASTGFFAPPLPGDLTGRPDVRERATGVNAFWWTLHEFCRDELLPFVFADAEDERNQYTMVVHQVAARLRMDAVPAGTDGAIAVDGRQVRTYDQLVDLISDKLSDDNTRSAWAGQVTGIGTVNAFLRRLRSSLRALRPLIRGDLPERPTRRVSTENQQLTVVDLHNLPERAQRFVVGVVLAAETRRKEEAGAGGLLFTMLDELNKYAPREGSSPIKEVLLDIAERGRSLGIILIGAQQTASEVERRIISNSSIKVVGRLDPAEAGRPEYGFLPPGQRQRVTLAKPGTMFVAQPEIPVPLAVEFPFPAWATRSSEAGELGVAAPPPGVNPVTGEIIGGRDPFKRLPSAPADDAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVG4</accession>
    <name>A0A010ZVG4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-type bacteriocin/lantibiotic exporter with N-terminal double-glycine peptidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CryarDRAFT_3884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3853"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458423" evidence="8">
        <location>
            <begin position="38"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="339"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EXG82684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="602" mass="64092" checksum="835A8E0FF92ADE3F" modified="2014-06-11" version="1">MRAAAGMAAGIAWRSARRPVVLLTLVALVGAAAPVGAAWATRGTIDRVATSAPLGELVAVAVALAVAGIATATLPQLEQYLQAEVARATNLAGAERLHSAVGGFVGLGRFEDPRFLDRLQLAGEGERAAGAIVGSGLASARSLLALGGFVGSLLVLSPAMTLVVLVAAVPTLVAEFRLSRARADMTFDISPVERRELFYRNLLTSSDAAKEIRLFGIAAFLRTRMLTERRTADDARRRIDRRDLVTQGGLALFGALVAGGGLVWAVRAARQGTLSIGDVSLFLLAIAGVQGALAGAISQLAQLHHQLLMFGHFRAVVTAESDLPVAPHPTPVRALTRGIELRDVWFRYGPDAPWALRGVTLTIPQGRATALAGRNGSGKSTLIKLLCRFYDPDRGTIRWDGVDLRELDPAALRERITAVFQDFVEYDLTAAENIGLGDLAGLADEGRIRAAARRAGVDAELAGLPAGYRTLLSRMFFTEADREDPSTGVVLSGGQWQRVAVARAFLRDRRDLMILDEPSAGLDAEAEYRIHAGLREHRAGRTSLLISHRMGSLRDADRILVLDGGELAEEGTHAQLLAADGVYARLFRLQAAGYADEPVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVH0</accession>
    <name>A0A010ZVH0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_3889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852627.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3858"/>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_11"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="312" mass="34334" checksum="CB3DC3193576DC2B" modified="2014-06-11" version="1">MTVPWWAWVAVMTAVAAMLAVDLFLHRDNHVVSFREAVIWSGIWIAAGIAFGAVLWSWQGGEVAGTYYAGYLIEKALSIDNVFVFALIFTFFSVPETVQHKVLFWGVIGALAFRLGFIFIGAELLETFFWTAYAFGAFLVWTGYTMAFRHGEQTPPDRNPVVRLVRRVVPTDARYHGDRFFTRVDGKRVATMLFVVLIAVEASDLIFAIDSVATILAITTSAFIVWTANAFAILGLRSLYFCLAGLLRRFVHLHYGLALLLAFAGVKLILSETPVGKLPIPVTLGVIVLTIGASIVASLVATRRADPTVGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVI6</accession>
    <name>A0A010ZVI6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852638.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3873"/>
    <dbReference type="HOGENOM" id="CLU_663623_0_0_11"/>
    <dbReference type="OrthoDB" id="437351at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="414" mass="46557" checksum="3438F77570593144" modified="2014-06-11" version="1">MTDRPASARAALDHQRSWFADVQRRAADGEPIVLANADAPQEIFRAMDVPYVVNQWWASIIGAKRLSGAYLSRLRGLGFPDTSEQYNSLALAGLLGPDADGGPWGGLPRPSLVVAETSGDVLHKVFGAWESELGVPYYAFESAAEPEVPVNWWELMPDRWEQAIGPARIDLMSEELLGLIRHVETLTGRTLRQSRLREVMRLSNEQAEWNRRTRDLLASARPCPVRVSDVIPSVMIPQWHRGTQWAVDAAERLYSEVRERVEAGAGAAAEPERLRLMWIGRGLWHDMDFYRRFERSHGAVFVWSMYLALAADAYARYGDDPLRALAARFCAFHDQMYTPPWSGEWYTKEARSHGVHGVVHLVSADSSNAWATSRCLRDAGFPVLEIELENADARAYDADEVNGRIERWLDGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVJ5</accession>
    <name>A0A010ZVJ5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852646.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_30_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459247" evidence="2">
        <location>
            <begin position="28"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="338"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="49259" checksum="6066282287D73BC9" modified="2014-06-11" version="1">MSARRTAIFLTLVVLGVTASVLSYATAAGSVGYLLGYAVVVGLAWRSAVRRRRPDRGPGILIAAAITLWMTGDLIEAVQYYFFTVPPVGPSDVCWLGGYPLLAVALIQMARRRAPGQLRGAVLDGATLTMAGAMLSWQFLISPLLGSGESLATSVVPALYPVADVVLLAGVLIIALSPGGRGRPTQFLLGGVTVYLAVDLGYNLLPYVVSYDLVARLGPLVLAGNGLLVAALLHPAGAELLRPGARLRTLHAARVLFLGCALMTAPTLAILRSDPGGTEAAALAATAACAAFILARFTTAVREQERSQAQLAYQAHHDPLTGLANRTVLHDRLGETGEPVAVLYLDLDGFKEVNDRLGHEAGDAVLQAVATRLSAAVRQTDLVSRLGGDEFVLLCPGATEADAIELAERVLSDVAEPVPYRGELLHVGVSIGIASRSDAADSAPVALLRSADSAMYDAKRLGRGHWVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVR6</accession>
    <name>A0A010ZVR6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inhibitor of the KinA pathway to sporulation, predicted exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3921"/>
    <dbReference type="HOGENOM" id="CLU_037266_5_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="187" mass="21000" checksum="AAA20C7D025A1FBE" modified="2014-06-11" version="1">MTAVSRILNVVDVEATCWAGHPPPGSVSEIVEIGLTVVDLDAARRRERHRILVRPVRSRVSAFCTELTGLTQDEVDRGVSFAEACRRLASDHRAGQRPWASWGDYDRKQFLRQCAATPAAYPFGRHHTNAKLVFTEAHGLRKRPGMAQALERAGLPLEGRHHRGEDDAWNIAALVLDLVRRDRWPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVT9</accession>
    <name>A0A010ZVT9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852710.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3946"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_2_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="528" mass="56877" checksum="E4EB939F24E43AB8" modified="2014-06-11" version="1">MASTRRRKPATTEYTDDDRHEDTKALHGMGYAQELERRMSKFSNFAISFSIICIVSGGINSLGQATSGVGGAAIGIGWPIGVLISGVFALGLAQISSAYPTAGGLYHWGSILGNRFTGWLSAWLNLLGLVTVLGAINIGTFYFVFGAFGERLGIEDTLTTRVLFMALITGVQALINHFGIGLTAKLTDLSGYLIFATAIALTIACLVAARDIDVTRLWTFHDYTGGEGSDAVWPKTVGIGMAFLLGLLLPVYTITGYDASAHTSEETVKAAHHVPSGMVSSVLWSGLAGWVMLSAFVLMIPDMDDAARQGWNVFFWAMDERMNSVVRDVLYVLIFVCQFLCGLATVTSVSRMLFAFSRDGGIPGASKVLARVSPRRRVPIGSIWVAATLATLFVWFTSSITIKGTPAYSIVVSCTVIFLFLSFTVPIALGLVAIGGRKWPHMGPWNMGITRYRIVAVLSIVAMALLFFIGVQPPNDYALEITIGFVVLALVIWFAVERRRFQGPPTGDIIAAREGAIRAAEEAVGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVV0</accession>
    <name>A0A010ZVV0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">CryarDRAFT_2443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850618.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2406"/>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_11"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="152"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG81332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="304" mass="32576" checksum="B3959A9C5276F39C" modified="2014-06-11" version="1">MIPHLLSAADLDADTATLVLDTATELAAAAGRSVKKFPTLRGRTVVNLFYEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTALTLQAMGADAVVIRHQASGAPHNLAQWVDGAVVNAGDGTHEHPTQALLDAYTMRSRLGRLEGLRVGIVGDVLHSRVARSNVLLLATLGAEVTLVAPPTLVPVGVGAWPVEVSYDLDTVLPKLDVVMALRVQRERMNASFFPTEREYARRYGLDAKRLAALPEHAIVMHPGPMNRGMEITPEVADSPRSTIVEQVTNGVNVRMAVLYLLLGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW09</accession>
    <name>A0A010ZW09_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 4">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850704.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2477"/>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_11"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="8">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="371" mass="38839" checksum="D00D3C0CDFC4F299" modified="2014-06-11" version="1">MRIGVPAEVKNHEYRVALTPAGVQELVRHGHSVAVQAGAGLGSSLADSLFAEAGAEIVEGPDAVWGEAELVLKVKEPIAEEYDRMRAGQTLFTYLHLAASKECTDALVDRKVTGIAYETVELADRSLPLLAPMSEVAGRLAPQVGAYHLMRSGGGRGTLMGGVSGVYAAKTVVIGAGVSGMNAAAIALGMQAEVLLLDTNIDKLRAADRIYQGHLQTVASNSYEIERAVLDADLVVGAVLVAGARAPKLVSNALVAEMKPGSVLVDIAIDQGGCFEDSRPTTHDDPTYRVHDSVFYCVANMPGAVPHTSTYALTNVTLPYVLQLADRGWKDALRADPALALGLNTYDGHVVSEPVAAAHGRTALALADALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW14</accession>
    <name>A0A010ZW14_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_4061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1945159_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459251" evidence="2">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="129" mass="13622" checksum="4023007A91C1F6A5" modified="2014-06-11" version="1">MNSKAALAAAGLASLGVLAVPQTASAAQPAGSRTAVPAAVSCGNPETHRVTSRLRTVGRSERRRCYSGSSVRVNGWVDDTNTGDGRCVTVDLYWSSGAHEWAQACNGETKQFRSSWQGGTVRVTIRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW59</accession>
    <name>A0A010ZW59_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Catalase-peroxidase</fullName>
            <ecNumber evidence="9">1.11.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_4108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4081"/>
    <dbReference type="HOGENOM" id="CLU_025424_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="105"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG82904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="680" mass="74263" checksum="8A203EAD71FF7687" modified="2014-06-11" version="1">MPEPHGGGLGLPAPTPSYYASVERPYSASLEARPARAAEERLDLRVLQKRPDPLGDDFDYPAAFGSLDLDELAHDVDAVLTTSQDWWPADFGHYGPLVVRMVWHCAGTYRVGDGRGGASASLQRFAPVDSWPDNRNLDKARRLLWPVKKKYGRRISWADLMVFAGNRALETMGFRTFGYAGGRVDVFHPDDVDWGPEAGWLGDERHTGVRTLDEPLAADQLGLIYVNPEGPNTVPDAVASARDIRVTFRRMGFDDEETVALIAGGHTFGKTHGVADPKYHLGPEPARADLAQQGLGWANSYGTGNAGDTITSGLDGAWTPTPTQWDNSYLENLFGYEWDVALSPAGLWQWVPRGGAGAGTVPDAHDPAKTHPPTFLTTDLALRYDRAYGPIARRFRDNPDQLADAFARAWFKLTHLDLGPRERYLGPLVPPEPLIWQDPVPADAGAAPDVAALKQRILDSGLTIPELVETAWASASTFRDSDKRGGSNGGRLRLEPQRSWAVNKPDQLDRVLRTLDALRHGISMADLIVLAGCTAVERAAGVPVPFTPGRTDAAPEWTDVASFAALEPLADGFRNYLDPRARRPAEHLLVDKARQLTLTATEMTVLVGGLRTLEHGVLSNAFFVDLLDGPPDTATRVDLVFGSHGELRAFAEAYASDDAAEGFVRDFVVAWDKVMNLGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW93</accession>
    <name>A0A010ZW93_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system, ATPase and permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_2602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2565"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="578" mass="62366" checksum="EFE0D4139958EF2B" modified="2014-06-11" version="1">MLIRLLRTHLRPYRRSLTVVVVLQFLQTLAMLYLPTLNADIIDYGVVKGDTGYIMRLGGIMLAISVGQIVCAVGAVYVGAKVAMALGRDVRGAVFDRVQAFSAREVGTFGTPSLITRITNDVQQVQMLVVMTLTMVIAAPVMCVGSILLALRQDVPLGSILLVALPVLVAVIGFVIARLGPQFRIMQVKLDDINRVLREQISGIRVIRAFVREPYERKRFAEANDELYDVSLRVGRLLSVMFPSVMVVVNVSSVAVLWFGGHRIDAGEMQIGALTAFLSYLMQTLMSVMMATFMFMMAPRAQVGAERLSEVLDTDTTVVPPSTATPLPEARGRLELRGASFQFPGAEHPILCDVDLVAGPGEVTAIIGSTGAGKTTLLNLIPRLADVTAGAVFVDGVDVRELDPADLSRVIGVVPQRPYLFTGTIASNLRYGNPDATDEQLWHALEIAQAAAFVRGLPEGLDAPIAQGGSNVSGGQRQRLAIARALVHEPEIYLFDDSFSALDYATDAALRAALARETTEATVVIVAQRVSTIRTADRIVVLDQGRVVGSGTHAELLESNDTYREIVLSQLTAQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZWT2</accession>
    <name>A0A010ZWT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homoserine kinase type II (Protein kinase fold)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035862224.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2764"/>
    <dbReference type="HOGENOM" id="CLU_1114824_0_0_11"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="282" mass="30782" checksum="34A54A69498E55DA" modified="2014-06-11" version="1">MDPGTLSRATAAVTALAGELRLPIDDVVVVRNSNKVSVRVLPADVFARVAPLGQEVAALEVELARRLAGGPIAALEPRVEPRVHERDGFAVTWWTHYEVVPAGPDLPGVYAGALRRLHAGLRTVELAAPHFLDRVAAAERLVTHRDETPALADADRRLLLDTLRDAGDRIRARGAAEQLLHGEPHPGNVLSTHDGPRFIDFETCCSGPVEFDVAHTPEEVGARYPNLDPVLLAECRRLVLALVATWRWDVRDEFPDGHHHGRTILSMLRQGPPWPTPGALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZX28</accession>
    <name>A0A010ZX28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system protein, fructose subfamily, IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CryarDRAFT_2882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570183.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2844"/>
    <dbReference type="HOGENOM" id="CLU_013155_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="11">
        <location>
            <begin position="8"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EXG81762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="379" mass="36810" checksum="195AEBD5110B2067" modified="2014-06-11" version="1">MTTPHLPFRRALLVGVSYAIPFVAAGGILQALGLLLAGGSVTGEPFSPLQRTGTLVFSVGALAFGLLAPVLAAAVAYALAGRPGLVPGLTTGVAAAAVGAGFLGALVGGVLAGVLAALISRIRRPEWTHGPVLIVALPVVATLVTGGLMLGVIGPPLAAVTRALTGWLGSLDGSSTVLVGAVLGTMTAIDLGGPVNKVAYAFAASGLTTLATPLVPDVTARTDTTATPPHSGAAMAAVMAAGMCAPLALALATRLAPNLFTDHERAHAPTAAALGALFVTEGAIPYAVADPARVVPAAVLGSATAGAVAAGAHATVGAPHGGVLALFSVGHVVVFLTAIVLGTALSCAAVIGAKSVTRAKRTAGTTGGRTELIDSESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXA3</accession>
    <name>A0A010ZXA3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase with GAF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570214.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2938"/>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_11"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="354"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="569" mass="60281" checksum="F52C5C8CE1369AAE" modified="2014-06-11" version="1">MMREDSAVGTGPVVRGTRLRTFDPSASEALGSTAHHVAVLTAMAAGAAAGLVYLADGERLRMVGAWGLRDGWQVLQGIPVSETVAGLVLARRSPIVVDDVGRDGRVPPSSPIFDHGGRAYAGYPIADGDGETVGVCAAMDYRPRHWEPRELTGIETSAKLCTALLRDLATEAEVGRRQGPLDAARFLDTERAVGHALAEALGIEQAGPTVLRAVCSSLGWSAGELWLADDDTDALRPVATYRDGDRPGLPVPPQLARGAGLAGSAWELNEVVWVRDLNGIDGATIRSGVAVPVPFSGSALGALCFFTDVVRDAESAVTILLTGIAGQVAQFLQRRRAEDAELALARSKDEYLFLVGHELRTPLTSIASYTELLVETPGMDAENVRLLGVIDRNTSRLRHIIDELLDLAALDSGHAELVWERLELATIVEAALADTRADADEAGVALRAELEPGLHVDGDGERIRQVLDHLLRNAVTHSPRGTVTVSTAGSATGAVDLVVADTGVGIPDDEGVEVLSPFYRTVLSREQQLPGAGLGLALSRAIVQAHRGTIRLMPNRPQGTRAAIRLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZXX1</accession>
    <name>A0A010ZXX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3158"/>
    <dbReference type="HOGENOM" id="CLU_039832_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="440" mass="45341" checksum="0E4AE61CB5636103" modified="2014-06-11" version="1">MSDLPVVVVGGGPQGLAAGAYLLERGLTPLVLEAGPSPAHAVSQWAHVRLFSGWNELVDPAAARLLEPTGWTAPTEGYPTGGEWIESYLAPLASALGDVVRVGARVTGVSRKGRDRLVDAGRDEQPFTVHVAYADGREERIDARAVIDASGTWTAPNPAGADGLPALGERAAVEAGLVTYLPPTPEQVEQFAGKHVAVVGAGHSAMTAVIQLGALAEAHPGTRISWVVRRGGTGISFGGGAADELPQRGALGLGAKAAVDKGFVELVTGFRTDRITVADGRSVLTDENGVELAPADYVVVLTGFRPDLSFLSEMRLELDATLQAPVRIAAEVDPNLHSCGDVRATGAADLAHPEKDLYLVGMKSYGRAPTFLAMTGYEQVRSVTAALAGDHEAAARVELVLPDTGVCGGSGAFDDPEAASGGCCGAPASPQIVELTVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZY52</accession>
    <name>A0A010ZY52_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3242"/>
    <dbReference type="HOGENOM" id="CLU_000022_58_3_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="717"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2331"/>
            <end position="2406"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3951"/>
            <end position="4026"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="5568"/>
            <end position="5643"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="7195"/>
            <end position="7270"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2366"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3986"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5603"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="7230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="7351" mass="762248" checksum="54DBDF9EB7758A2B" modified="2014-06-11" version="1">[encoded data, 7351 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYK1</accession>
    <name>A0A010ZYK1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035851925.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793270_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="144" mass="15593" checksum="725F1B93F329EE38" modified="2014-06-11" version="1">MVRPARAEAVHTQAAAAGFDVQVHSRRNPNHGARCRIGQAYIKFDYNVGRGRTRYDIVVRLLVGAPSDYPDWNAVVNGRVIFTTGRLQAPGGPNREGYIHFSPNGTGTVAIEAFDPATGAQAYTGMSPINLYCGDDIDVLIFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYW8</accession>
    <name>A0A010ZYW8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852185.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3551"/>
    <dbReference type="HOGENOM" id="CLU_018204_5_1_11"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="3">
        <location>
            <begin position="186"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="319" mass="33441" checksum="90CBF3B0CA7BA401" modified="2014-06-11" version="1">MRFALSEEQRAFGDALDALLTAADVPRVTRRWADGDPAGGLRLWARLAELGVTGLGIPEEHGGLGGTPLDVAVALERLGYHGVPGPWIETVALAPALLADADPTVLPELAKGTARITCAAPPWAPYALDTDTATHVYLLTDETLARARAGDPLRSVDPARRLSALTPVENLGRVDGRAVDAVTLGAAAWLVGAGQRLLDDTVTYVGTRRQFGRVVGEYQAVKHALADVLVGLDFARPLVHGAARALAAGHGSAEASGAKVLASDAAHRAARTALQLHGAIGYTREFDLSLWLLRVRALVGAWGTPAFHRARVATALRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AB42</accession>
    <name>A0A011AB42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847743.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.244"/>
    <dbReference type="HOGENOM" id="CLU_771237_0_0_11"/>
    <dbReference type="OrthoDB" id="1454169at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="338" mass="36126" checksum="4CC249682C65A7AF" modified="2014-06-11" version="1">MNRGSRLPLSHLADMTDDAGLFEHALLTAPRREHGYCLDDVARGLAVLCRFPETSFLSDRLLTIYLGFTLAALAPDGRCHNRMATDREWRDEPGLGDWWGRALWGLGAAATHAPSNEARKRALDGFRVAAQQRSPHARAMAFAALGAGEILIADPREEAARALLHDALDTLGPADPSPGWPWPEPRLRYANGAVVEAFLVSGVALPAPRAVLTGLRLLTFLMDAESHDARLSVTPTTGRGPGEAGPGYDQQPIEVAALADACARAYGITGDPQWREGVRAAWAWFRGDNDAGVPMFDSHTGGGYDGLEPGGRNLNQGAESTLAVLATAQQAQRLGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ABT2</accession>
    <name>A0A011ABT2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, histidine kinase/DNA gyrase B/HSP90-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021898_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="579" mass="61593" checksum="4E8F9A73ADB77C1D" modified="2014-06-11" version="1">MRAVLPVPGHTGRAALVGVGVGLLTLLCGVPYWCEHLTSAAVAVPAAGVFGAAGGLLLGTGDSRQRSGQMLLVGAVFVAFAWTAIWDSGIWPTFAFYSEGIGLTVSGAAVLAYPAGRLVDRADRYWVYAAIGVLIVGELFVELVSLPEWNDLSPDVFWPSLAPNRSLFDAAISTVTGLQVVLAGWYLVLLVRRGRRLSTTERPAAIPVLIGTGIAAAAIASTARTRTFTDLESLLSLYVVQNTISAVLALAVLSGALRERWREVDAPHRVIRMTSSTSSVATVRDALAAALRDPRLRLLFWVPAEHSYVDRRGHLVLHPSATTGRWLTEARMDDRQPLALVELDDALRLRRGMVDAVLRAGSQALLTAQLQAMATTQLEQVLAAQARVEERETAERQRLEKDLRDGAQRQLAALAEQLCGLDALGEPARTVVATCHDEVLGTIEDLEALARGLHPTVLRTDGLGAALDEVAVRLGLAVQLAVYAGRKPPAVEATAYFALCEGLTNVAKYAPEARVRIEVTEADGWLHGVVADDGPGGARVVAGGGLAGIDDRIRALHGRTLVESEAGTGTRLRVSLPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACK7</accession>
    <name>A0A011ACK7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848518.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.779"/>
    <dbReference type="HOGENOM" id="CLU_028458_3_0_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="320" mass="34889" checksum="3C580F68809A8412" modified="2014-06-11" version="1">MSFPTHAGEFALGTFAHVGGRPFPGLVVDGRVRDVSALGRTVRDLLVDWDSTLTSLRRLAADPRGDWRGGDTLLVLPPLEPGQILQSGANYRQHVIDLVAAEREAANGATPEEARADAAAMMDARAESGTPYLFLGSPRAMCGAFDDVVLPREGEQHDWELELALVIGRPGRRIPRSEAMSHVAAYTMSNDITTRDRLYRPDLKAIGTDWFVAKNAMTFLPTGPFLVPAEFVGDPMRLRIRLEHNGVVRQDESTKDMIFDVARLIEYASTITELRPGDLLLTGSPAGNGAHWDVFLKPGDVLECSITGLGAQRNTCVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACQ6</accession>
    <name>A0A011ACQ6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type proline/glycine betaine transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_0867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848607.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.856"/>
    <dbReference type="HOGENOM" id="CLU_072064_0_0_11"/>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459438" evidence="2">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="43"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG79821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="322" mass="35064" checksum="EC7B8C125F685D0A" modified="2014-06-11" version="1">MFSKLRLVAPLAALLLVASACGGAKVGEESGGSDAGSKGKCGTVNLAINPWVGYESNAAVVAYVAEKQLGCKVVKKNILEQVAWQGFSTGVVDVIIENWGHDDLVKKYITDDKVAVDAGSTGVPGKIGWFVPPWLAKEHPDVLDWKNLNKYAAEFKTSESGGKGQFLAGDPSYVTNDAALVQNLKLNFKVVYSGSETALITAMRQAEQQKKWLIMYFYTPQWFLNEVPAVNVKLPEYKSGCDADAKKVACDYPEYDLNKIVSKKFADSGSPAYTLVKNFTWTAEDQNEVAKAIAVDKLPAEDAAKKWVEAHQDKVDAWLQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ACZ2</accession>
    <name>A0A011ACZ2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fatty-acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.957"/>
    <dbReference type="HOGENOM" id="CLU_027359_1_1_11"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="331" mass="37528" checksum="248AFF7D62B10205" modified="2014-06-11" version="1">MTPTSATAAEETATPAAAEAPKRSGQRPLIFGRKGNIEIAFLWFFVVVPFVAVIAAVPWAWGWGLTWVDVAIFAVFYVVTGFGVTVGFHRYLTHGAFKAKRWMRIALTVAGTMSVEGAPIRWVADHRRHHQYSDQEGDPHSPWRFGESTKGLFKGLVWAHVGWLFERDNSNARRFAPDLIRDPDIRRIQKNFVPIMLFSLLGPALIGGLVTWSWWGAVTAYFWAGLVRIALVHHVTWAVNSVCHVVGEQPYRSNDKAHNFWPLAILSFGESWHNSHHADPTCARHGVDKGQIDTSARLIWLFEKAGWVWDVRWPKRERFESRRNEPVAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD31</accession>
    <name>A0A011AD31_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848726.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.997"/>
    <dbReference type="HOGENOM" id="CLU_097805_1_0_11"/>
    <dbReference type="OrthoDB" id="1922611at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="163" mass="17416" checksum="D899221A718DDD64" modified="2014-06-11" version="1">MTGLSEADHETVAAQLGRVPRGAIGVAHRCPCGAPDVVETAPRLPDGTPFPTTFYLTCPRLAGLLSTEESGGLMRDMSARLEEDPELAARYETAHQDYLERRRKLGEVPEIDGVTAGGMPTRVKCLHALAGHALAAGPGVNPFGDEAVEAVGNWWERNPCGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AD74</accession>
    <name>A0A011AD74_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_1064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848767.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024186_3_1_11"/>
    <dbReference type="OrthoDB" id="279287at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="297"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG80006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="447" mass="47779" checksum="11CCE54A1E6C1283" modified="2014-06-11" version="1">MSDRLHPVDVSFLSAETPNTPMHVGGLAILEPARSGLDVAGLRRRVEQRISLVPRFRQRVRWVLGGLTQPVWVDDSRFDLAYHVRRTGLPTPGSDEQLHALVGRLLAGSLDRSRPLWELYLVEGLRDGRVAVLTKSHPALVDGVGGVDLLHVLLDDSPATADGVTPIWRPAPEPGPAELMVDAATHLVRHPGQLVGAMKGAGRLLASARPAPASPLNAEPGKQRRFASTHTDLDRYRALRSRPNVTVNDAVLATVAGALRAWLLYRGEPVRPDSVIRALVPTSVRGGPPAAFGADVGANVATSLVDLPIGEPNPTVRLTQIAYAMRAHAEPGRRVGADALVKLSGFAPATLNAMAVRAASGLSRRLFNLVVTNAPGPQRPLFVAGARLREIYPFVPLAPGQGLAIGVTSYDGQVYYGLNADWDAMPDLDVLAGLLDESIDELTEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADC2</accession>
    <name>A0A011ADC2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="168" mass="18431" checksum="1E18C60E6A8B7B16" modified="2014-06-11" version="1">MADSSAIAPEQAPATPDDTVTELGRQLARFGRAMVRYKAQQAASAAYGLLFPLAERPQRAGALAEAVHADPSTVSRQIAQLVDRGLVERQPDPADGRACVLVPTEAGHETMATLRRRRDEHLAAVLQHWPAEDVHELVELLSRFITDFETARPPAVRPEETEIPTQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADL7</accession>
    <name>A0A011ADL7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081592_2_0_11"/>
    <dbReference type="OrthoDB" id="1887037at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG80146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="235" mass="24449" checksum="C2C5EE82D07A8FE7" modified="2014-06-11" version="1">MQCAQIRLALSALADREEPGTDRADVDAHLAGCAECRTWHAAAAEATDAARAAQRPAAHVPDLTEQVLAAIAADTAARRRPRFALTRGATRAHPPSRAGDAAGWTGFLHAGVLRWAVGISAVAQLLLALPALFAEPGTADVALHTGREMASFDVAVAIGFLFVAGRPAWARALVPVAVALAGCLLLTSSIDVVDGAAQLSHELNHLLAGVQAALVWLLARTDRTPTAPEPLPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ADX8</accession>
    <name>A0A011ADX8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849050.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1285"/>
    <dbReference type="HOGENOM" id="CLU_111671_1_1_11"/>
    <dbReference type="OrthoDB" id="1942143at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="120" mass="12702" checksum="7399C3F66008358D" modified="2014-06-11" version="1">MTRATASFTVDSFDPVGEPDGIISSVVLTKTFTGDVEATSTVRMTAAAQTAYVALELITGTLHGRKGSFVLLHAATPEDTRWVIVTDSGTDELTGLSGTAVLVRHDDGSHTFTVDYDLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AE80</accession>
    <name>A0A011AE80_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849178.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1382"/>
    <dbReference type="HOGENOM" id="CLU_409773_0_0_11"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="670" mass="69037" checksum="127D2C1EE91E68DC" modified="2014-06-11" version="1">MTSVGADTVDLVCGPDGPLPEGRQRYRLTGRLGSGGQADVFRGVRLSSGVRSAPVTVKVFREDHRRPVLDQMRSWDKGDAVLMDLNTRDVPGICLRVDGFYGAPPVAANATSVLGSSTDRRIPFQVLDYLPGHTLLQHVAKQAGGEAVPRLNGPAVLTTLARTIALLHRPADRGDTSVLHMDVKPANVLVLPTGEIRLIDFTAARYHDPQHITTIAHTPESAGPEAFTGVVGPSYDVHGFGSVAYHLVTGWLPRADRATSHYDGALVAPGALRRHPLLDANPALAAHLLAPLDDDPGKRPLSSELVNWVTTLARLASAVPAASTHVDWIAGAATGPTPTRVERIPPQAPSAPAARASAPIRGAAKVGTAAVGGAAAAAPYAASAPASGGPAYGAAPGSGGPAYGASGSGGPVYGAPASGGPAYGAQAPRPPAPSAPSSGGPAYGAAAPGPGGRVAPNPTAPLPDLPGAKGAQSAPPKTTAMPRYSDADAPQSGPPAGPKIRSGVAKVGPRQPGVDDVDNSRRRRDEGHDPYGDQHGGGQPPQQQPSGPLRRSGKKYTTFATVVAAAGWLLWLATVAIISGADTGEPITAAILVVVAAFAVWWLVRLGGHLIRSTLERGSRRSTFLQNAVTGTFILLCGLFFATRGVSNFSDVGAMVSEWWSNLWDSIWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AER1</accession>
    <name>A0A011AER1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1578"/>
    <dbReference type="HOGENOM" id="CLU_097480_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="190" mass="20406" checksum="D82CC95909C44964" modified="2014-06-11" version="1">MIEDAAAAEASLDPIRARILAELAEPHTATTLANRLGLARQKVNYHVKTLEQHGLVELVEERRKGNMTERVVRASAAAYVISPAALAAVAPDPSRSPDRLSAHWLLALAARLVRETGALINGAARAEKPLATFGLDAEVRFARPADRAAFLGELTASLAELISKYHSEAGREHRVVIAVHPSITEDGDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEZ4</accession>
    <name>A0A011AEZ4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentulose/hexulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569925.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1661"/>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_11"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="248"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="494" mass="52877" checksum="8C9759864850EEDD" modified="2014-06-11" version="1">MPGYLAVDLGAESGRVLAGAFDGERLEVREIHRFANRPVRDGDDLTWDLKALHEETVRGIGRAADRVEDVRSVGIDGWGSDFGLVDADDRLVAAPWHHRTPRTAAMVAELQKAVEPQALYDVTGTQFLPITTACQLLAMRGSGVLDRADRLLMLPDLIAGRLSGVRRTEQTIASTTQLWDIRRGEWAAGVIDHLGLPRHLFRAEVVPAGTALADLRTRPERLAVVAVAGHDTACAVAAMPSTGDDVGFVSCGTWSLVGVETTAPITTPDARVAGFTNELGVGGRFRFLSNVNGLWLLQESRRVWAGEGRDLGYPELTALAAGSAPYRSLIDPDHPSLLSPGDVPGRIAALCRLTGQPVPTGPAEVTRCILDSLACKYHWVLTRASAISGQPVRTVHLVGGGAANTVLCRLTAELTGLPVVAGPYEATAIGNLLVQIMADGKLSDLTEARALVRSSVPLRRYEPTGDSTGADDAYARFRDVVTRLATETLRDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEZ8</accession>
    <name>A0A011AEZ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease component of ribose/xylose/arabinose/galactoside ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_1695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849571.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1666"/>
    <dbReference type="HOGENOM" id="CLU_028880_3_3_11"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="335" mass="33870" checksum="66B2CBA367CBEB69" modified="2014-06-11" version="1">MTTVRTGRPPVTGAGLASIARRAGAPLVLVLVLVIGATAFGDGFAGPQNIRNVALDSSYLVLIAIGMTFVVISGGIDLSVGSVFALAGVLAAIGAQWGSLTALVLPLVVCGLIGLLNGVLIGRARIAPFIVTLATLLFARGLAFAASQEGNKVYLMPPDLTLTRVGQARTLGVGTPVLVAVGVFAVGLVVLNRTRFGQAVYAIGGSPESAELMGLPVARIRVSVYVLSALLAALAGILVAAQTSSGLPTIGEGRELEAIAAVVIGGTLLSGGIGTLTGTLAGALLLKVIQNLINQVGTLSSYYQQVVSGVFLLLVVLIQTGLSRRGAGRVDEEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AF42</accession>
    <name>A0A011AF42_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_1735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569934.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1705"/>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_11"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="249"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG80651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="484" mass="51680" checksum="F7964E5A20BF91E7" modified="2014-06-11" version="1">MLVLDDVSKRFGGTTVLDHVTLRVRAGEVHGLVGQNGAGKSTLVKILSGLYPDHEGRITVDGRVAALSDPRASRAEGIGVIHQEFSLVPQLTVAENLLLGREPGRWGYRQRRTEARARTLLESVEVEIGAPLTARVAELGPAVRQRIEIVKALAADVRVLLLDEPTARLSEAERRSLFAVVRSLADRGVGMIFISHFLDEVREVTDQLTVLRNGRVVASAPTAALSVGQITALMVGDELRETLTAERAAHRADDARPVVLALRGTAADVELRAGEITAVAGLVGSGRTRLCRALSGAAPARLELRGRPTRFAGPRAAVAAGVVHIPEDRRHQGLCLSHSVMRNLALTALSRGLGRWGVVRRRPVRRLARGLVADLRISPADIDAPAGTLSGGNQQKVVLGKALAAAPDVLIVDQPTAGVDVGTKAQIHHLLRERADAGAAVLVVSDDIDELLALSDRFHVLTRGVLSWSGTRVSREELLAHISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGA5</accession>
    <name>A0A011AGA5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CryarDRAFT_2151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2117"/>
    <dbReference type="HOGENOM" id="CLU_057101_0_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="13">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="12">
        <location>
            <begin position="108"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EXG81056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="266" mass="28082" checksum="0993AC7F2D8A12DC" modified="2014-06-11" version="1">MFVPDDTVIAAVAGVLGLVVGSFLNVVVYRVPRAQSLVRPASHCPACTAPIRPWHNVPVLGWLVLRGRCADCREPISVRYPLVELGTGVLFAAVTARFGLSPELPAYLYLAAIAVALALIDLDVMRLPDRIVLPSYLVTAILLLVAAVAAGSWQDAGRALLAMAALYAGYWLLAFVYPDGMGFGDVKLAGLLGLYLGWLGWNSVWVGTFAGFLVGGVVGMVLLATRRATGRTAIPFGPAMLVGGFLAVFAATPITVWYSSLLLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AGQ0</accession>
    <name>A0A011AGQ0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631235_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045535">
        <property type="entry name" value="DUF6430"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20016">
        <property type="entry name" value="DUF6430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="102"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="434" mass="49029" checksum="33D88DFCF1AD5D93" modified="2014-06-11" version="1">MSRPSVSLLGPAEIRVSDRVVRPTPLTTAVLTRLVLADREPLTVDEIFTAVWGDRRALTRADRISVQKRILELRKILADPSALVTEAGQVSAYRLTIPRADVDVHAFRDLVERARRETPVNAVTLLEQALGLWRGRPLFDTERYPFAQPAIRALRELQDTATLDLVTAYADIGQPEKALSTGAALLDRRPDLPGAADAVARLRRRVAERRPGVEHRDFPGLGTRVTIRADDLFAQRDAQLVIGFCDTFDTSTDRNVVISRATVQGQFLHWAYDGDTGRLNRDLRSALRGARPERVERREDKRRGKRARYPLGTVAVLHRDDRRFFCVAYSVMGNDLVARSDLESFRASLDRLWDAAVRYGQREPLAVPLLGSGLARLDGTDRTELVTLLIESFLRHSRRQVVSRELRLVLRVEDLDRVDLLEVAAFLRAQNDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AHX7</accession>
    <name>A0A011AHX7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/amide ABC transporter membrane protein 1, HAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_2734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2696"/>
    <dbReference type="HOGENOM" id="CLU_039929_2_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="324" mass="32753" checksum="25CE02C1D656D2CF" modified="2014-06-11" version="1">MSTAEALTARWRSVPAAPAVAVGLVFVLIAAALLKSGSGTITGQAVLTGLVNGGVYSLLAMGLTLIFGVLDIVNFAHGAFLAVALFTTYQFVATTGANPYVALPIAIAALFALGALAQWALLNHTMGRPLESQLLLTLGLSLLVSNLLLLAFGGDPLSVAVAGDHGINVLGAVANQTRLVAFGGALVLAAGLYLLLGRTRLGRAIRAVAASRQGAGLVGIDVRKIYVLTFGLGTACAGAAGMLIAPFTTITPTAGDQFNILAFVVVVMGGLGNVAGALISGIIVGLVEQLGGVLLTGQSPLFGVFLVFILILVARPQGLFGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKG8</accession>
    <name>A0A011AKG8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725728.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2192633_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="108" mass="12136" checksum="C037496A204BE73E" modified="2014-06-11" version="1">MTSVIAEPRRPETWGHHRRWRDLTVGERRFVVAGTALDTALKVAMLVDLRRRPGEQVRGPTWAWASAALINSAGVIPAAYFAVGVTRSGRHGLRPQLPDHRQPRRHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKL1</accession>
    <name>A0A011AKL1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570563.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3667"/>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="233" mass="25735" checksum="6C3E8B4FB5A3C710" modified="2014-06-11" version="1">MKPLREGSMTERAAAALRTSILNGELEPNVLHATHTVADQLGVSRTPVREALMQLASEGLVRVQRNRGFVVLRHSPQDLREIFSLRILLEVPATRVSATIAGPADIARLEADVERMREAMDDAEKFLRADRQFHRSLLAIGGNERLVDFVDNLRNIVLTSGVSTANRSESIEEILEPHVELLELVRRNDAVSAAASMSRHLMSTGVKLIAQEFGPDTADEFRRTVSMLVPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AL72</accession>
    <name>A0A011AL72_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_3896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570630.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3865"/>
    <dbReference type="HOGENOM" id="CLU_017028_7_3_11"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001459610" evidence="2">
        <location>
            <begin position="31"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="81"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG82696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="521" mass="54583" checksum="15017358E9FE5EC4" modified="2014-06-11" version="1">MPTLHRSRLLAASVASAMALTLAACTTSGSSSTSGGNTSELNLQFTGVPISLNPALAGAGGSTVYTALAYDSLIHLSNEGKLEPDLAESWKYVGTGNKVFELTLREGVKFASGKPLTAEAAVASMQYFLKAGGPLTPSAGAVDKVEATGPRTVQVTYKSPNPDAAGTMDQYHGIGVLIGPDGVANPQSLLTKSDGTGAYVYDNATSVAGSRYSYTKNPAYFNPKAQRFSKVSVRVIGDPQAVLSAVTTGQVDYATGSPATADAAKSAGLNIVKAPFFNWELVLGDTEGTISKPLADPRVRQAIGYAINRDALSKAFGADFTKPSTQQLIEGADGYDESIGYTFDLQKAKSLMAEAGYAKGFPLTVLTESILDRNTTYSQAVADALKAIGITVTLKVISTTVPAFIGEATSKKYAASIWPSAGPNMFQNYSQVSGGLFNPFGHKDAQLDGIMQRASAAEGSERTGLYQQASKRFQELAWLIPLIATENVYYSSAKLEGISASVGNPNPMPVGPTPELAWRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011ALV0</accession>
    <name>A0A011ALV0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_4125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852989.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4098"/>
    <dbReference type="HOGENOM" id="CLU_001570_15_0_11"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="442" mass="50228" checksum="222B3DD55305AA0A" modified="2014-06-11" version="1">MTAEALPIPPLRRDDRGLPFVGRVLDYAKDPVGLFRHHYERYGPVAPWYALGRTSVMLLGPDACGEALQNRDKAFANGPAWSQLVGPFFRRGLMLLDFDEHKGHRRIMQEAFTRPRLESYTRRLHPAIETGLAGWNADREFPSYWRLKQLTLDIAADLFMGGAQDTSRAEMDRVNKAFIACVQAAAGIVRADVPFTRWGKAYRGRKVLEKFLRHYLPVKRAQQTDDIFSVLCHIETEDGDRFSDDDVVNHMIFLMMAAHDTSTVTTSTILQYLGQHPAWQERCREESLALGPEPTMAELEGLVALDLVMKEALRLRAPVPVLVRYTVRDTVVQGVRIPAGTSAALGLQFTHLMEDYWSNPTAFDPERFTPERREDRSHRFAWEPFGGGVHKCIGLYFAGLEVKAIMHRLLREHRWTVDPAYEPPLDNHSLPFPKDGLPIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFW0</accession>
    <name>A0A010YFW0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847565.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.130"/>
    <dbReference type="HOGENOM" id="CLU_131550_1_3_11"/>
    <dbReference type="OrthoDB" id="1996962at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="67" mass="7376" checksum="988E8F4686A34E3F" modified="2014-06-11" version="1">MDSTAFVTASWRKSRRSATINCVEIAETPDLIGVRDSKNPEGAVLAYPVARWAAFLHGVKLGEFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YFY9</accession>
    <name>A0A010YFY9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063725849.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="268" mass="29624" checksum="1C414F7B4101A47E" modified="2014-06-11" version="1">MVEQVFAPKSQYRQIADLLRERIETGFYLPDDPLPSEPELASELGVSRVTVNKAISLLRTAGLVRVRRGSGTYVRSTPRITRDARYRYANPRAAELEGRALGLSPRAECTEVSKVEASTEVAVALGIDAGDPVVVRHRRLFADDEPTRLADAYLPWDIAEDSGLLEPDGAELLESDVGSGAVYAYLAERGHGPARFDEDVTVRVASDAEARALDLEDGQPVIHITHVARDADDRPVEVALHVMPAHLWRLHYDWSALRDDEYGAENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YJA5</accession>
    <name>A0A010YJA5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_4_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="167" mass="17681" checksum="B5E39E9230E33B9B" modified="2014-06-11" version="1">MVLSIRDGKPPVGAPPGAFDVDPDEDFDDPADDIAATLTAFMPVSLFPPIVAISVDLSSYLAEVLQRRGHWGLSVLGSSQAALAGRFSAAGRPSARLLLASEEHHRGALTGALLLDRAGATLECVTDSHREVGDHLLVTAAVVGAAIGTKDPLVRYDRAYRQLTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQJ3</accession>
    <name>A0A010YQJ3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119016_1_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="146" mass="16405" checksum="9CCB19FD666AAB04" modified="2014-06-11" version="1">MFRMTRARRAGDSLMGPLIRLGLVPHSYLLTTRGRKTGQFRTTPVTLVEAHGRRYLVAPYGPVSWVLNTRAAGRVGIARRGREVECTVREVPPAEAGPVLKQYVRLARPTRPYFRARTDAPVEEFVAEAGRHPVFELTVLGGERWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YQW5</accession>
    <name>A0A010YQW5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852513.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3756"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_11"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="471" mass="50370" checksum="191E5EAF2CDD8543" modified="2014-06-11" version="1">MGRIRTNSSTAEDLLITLDRSAADPLHRQIAASIRGGVRDGRLRPGTSLPPTRTVAADLGVSRGVVVEAYQQLVAEGYLTSRAGGYTRVAAGPVPASADRRTADRPPARIDFGYGRTDVSSFPRAAWLRSVRTALTTAPNERFAYLDGRGVPELRTALSDYLNRVRGTSARPENVVVCSGYGQGVGLLIQVLAARGARRLAVEDPSADDDARPLAAAAGLDVVGVPVGPDGILVDELERTDADAVVLTPSHQWPTGGVLSATARARVIRWAQARDALVIEDDYDAEYRYDRSPIGAMQGLAPDTVVYCGSASKTLAPGLRLGWLLAPAHLVDAIAAAKVLADRGSPVLDQLTFADFLTRGEFDRHLRRMRPVYRRRRDALLAALRTWLPDLEPTGVAAGQHVVTWLPRTLDEDAVVVAAARHGLIVRGLAPYRLDPDGPGGLIFGYATLTERAIAEGVEALADALSGLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YRQ1</accession>
    <name>A0A010YRQ1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CryarDRAFT_4099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852949.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.4071"/>
    <dbReference type="HOGENOM" id="CLU_079086_5_1_11"/>
    <dbReference type="OrthoDB" id="1768508at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG82895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="204" mass="21364" checksum="ECD7675482A4D0B6" modified="2014-06-11" version="1">MLTLFAVAAGLELIGVAFDVAVLQWVAKPLLAPLLAIYLLRRRGFGPVVVALGFATAGDVALLIDDERAFLVGMAFFLGTQACLISVFTRRGRLRRGALAGYAVLWAGANAALWERLGDLRVPVLVYSLALSVMAATAAGISRRVAAGGALFLVSDFLIGLGAADITVPGQDLLVMVTYIAALALIVTGWARLDPDAELGKPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVL0</accession>
    <name>A0A010YVL0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">CryarDRAFT_0206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847663.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.193"/>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_11"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EXG79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="199" mass="21941" checksum="089C932362FACE1F" modified="2014-06-11" version="1">MYEGAVQDLIDELGRLPGVGPKSAQRIAFHILNADPVDVKRLAEVLNRVKVEVRFCRICFNIAESDECRVCRDARRGDDVICVVEEPKDVVAVERTREFRGKYHVLGGAINPLEGVGPDQLRIRELMTRLQSGLVKELILATDPNTEGEATATYLALLVKPMGLRVTRLASGLPVGGDLEYADEVTLGRAFSGRRSLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YVQ8</accession>
    <name>A0A010YVQ8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100184_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15592" checksum="3C02375D22BB48F7" modified="2014-06-11" version="1">MDVTATATQVRLRIDPTLSGKGMLDGGWWPHSTDPLSELPPLIEALNKQFGLVHRITFNKALWQSTPRRITVAGRAIRLGWYGPSDIHEISVSTEGRFRLDLLVVPPDTSEGSAAAAMAAAASGTNGNHGASLLESEDAGNTEGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYN7</accession>
    <name>A0A010YYN7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">CryarDRAFT_1399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035849165.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1373"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="324"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG80328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="556" mass="61788" checksum="F67E7C03AC3B1431" modified="2014-06-11" version="1">MAQYIYTMRKVRKAHGDKVILDDVTLSFLPGAKIGVVGPNGAGKSTVLKIMAGMENASNGDALLAPDATVGILLQEPPLNEDLDVRGNVEEGVAEIRGVLKRYDAVNEAMGEPDADFDKLLAEQAELMDKIEAANAWELDSQIEQAMDALRCPPGDADVRVLSGGERRRVALCKLLLQAPDLLLLDEPTNHLDAESVLWLEQHLSKYAGAVLAVTHDRYFLDNVAEWILEIDRGRTYPYEGNYSTYLEKKAERMKVEGQKDAKRAKRLKEELEWVRSNAKARQAKSKSRLARYEEMAAEADRHRKLDFEEIQIPPGPRLGNVVIETDKLTKGFGERVLIDNLSFTLPRNGIVGIIGPNGAGKTTLFRTLMGEEKPDSGAVKIGETVQISYVDQGRGGIDPKKTLWEVVSDGLDYIQVGKVEMPSRAYVSAFGFKGPDQQKPAGVLSGGERNRLNLALTLKQGGNLLLLDEPTNDLDVETLSSLENALLEFPGCAVVITHDRWFLDRVATHILAYEGDSQWYWFEGNFESYEKNKVDRLGAEAARPHRVTYRKLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010YYY9</accession>
    <name>A0A010YYY9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">CryarDRAFT_1512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051571948.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1485"/>
    <dbReference type="HOGENOM" id="CLU_106710_3_2_11"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EXG80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="171" mass="18548" checksum="E2DCF4C90852D18B" modified="2014-06-11" version="1">MSIEISNESGHEVDEAALLSVARSTLDEMGVNPMAELSILLIDVGYMAELNHRWMEKTGPTDVLAFPMDELDADRGPGADEDGPEPTLLGDVVLCPAVAEKQAKVAGHSTPDELMLLTVHGILHLLGYDHAEPEEEREMFGLQNRLVSAYRRSIGIPAVADIPLKPTVSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z182</accession>
    <name>A0A010Z182_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_2296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850402.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2261"/>
    <dbReference type="HOGENOM" id="CLU_028458_3_4_11"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="30033" checksum="5311FC7894A0047E" modified="2014-06-11" version="1">MRLAHARTADGDQPVVHLDDRWYDLRPLHAAVTPAVLAPDALAAIRAASLPAVEEPTEFAPPLAGIGKILCIGLNYTDHAEETGATPPAEPILFMKAPDTVNAPNDDVLIPRTSVKTDYEVELAIVIGSTARYLASPDEALAHVAGYAISNDVSERTFQIERGGQWDKGKNCETFNPFGPWITTSDDIADPQDLGLKLWVNGDLRQNGNTRNQIFGVAHVVWYLSQFMTLYPGDVINTGTPAGVAMGRSDGQFLRDGDVVEVEITGLGRQRQTFRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z4Q9</accession>
    <name>A0A010Z4Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_3506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137187_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458995" evidence="1">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG82333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="143" mass="14761" checksum="190522B6E8213D82" modified="2014-06-11" version="1">MKTNRVRNALSAALVTAGIAAGLGLTAEPALAASCTGTADRPNTNGKTRALIPAIGRDTNCTLGNGNQSSAVRALQDSLNRCHGAGLTVDGIYGARTATAVRNVQRGANIAQDGVYGPQTRNAMLWAHYYYSGGAFLTCGTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z595</accession>
    <name>A0A010Z595_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter membrane protein 2, CUT1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_3708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852376.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3674"/>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG82518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="277" mass="30621" checksum="DB850E2B5180A8D9" modified="2014-06-11" version="1">MSTSVRAALAWCGLHAVAVAMAIGFLAPLLFLLLTSVMTDQQALTSDLWPRDWQWSNFVTVFDKAPMLGYFAHSLFYSITATAAMLVSSVPVAYALAKLRWRGRTWAFYLVIVAMLLPPQVIAVPMYVMWAKLGLTGSLWPLILPNLFGDAFSIFLLRQFLVAIPQSYIDSARIDGASELGVLLRIVVPMARPGIAAAGLFMFLKTWNDYFGPLLYTGENRANWTLSLGLAAFRSTHQVQWNLTMAATVLVMLPVVVLFFFAQKSFIEGIKLSGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010Z5E0</accession>
    <name>A0A010Z5E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_3755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3722"/>
    <dbReference type="HOGENOM" id="CLU_036399_1_0_11"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="443" mass="47761" checksum="1C0687C9F9ADA153" modified="2014-06-11" version="1">MRPDRDRPFVDVAELVGDPSRARVYEHGWQSWSPTGIYPATGTSQRPADATAQTMVYRPGRPAPARGFQGEGLIAVQPAPHAPVHIWSSSAPERTVPSIRVRAERDRLVVSADSEVTVSVHDTGLGTALARWAESLAVRLGVGPVRPTPPVWCSWYCYWEAVTAEAVLANLDAIVDARLPVEVIQVDDGWEAGIGEWRAGGDWAGSLTGVAARVRDAGLRPGLWLAPFLVGARCTLAADHPDWLVGGADAGHNWGQDLAVLDITRPAAAEHLTGMLRALADAGFDYFKLDFLYAGALAGRRYADCSPEAAYREGLELIRAALPEGTTLVGCGAPLLPSIGLVDAMRVGPDVAGEGARETPERRPAAIRTGSARSFQHARWWVNDPDCLLLRPEVPDREEWAGYVSSSGGVAGFSDPVWQLDEWGLDTARRLLRPSSTEHVDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZK30</accession>
    <name>A0A010ZK30_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_0039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035847386.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056729_2_0_11"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458325" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="106"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="223" mass="24160" checksum="4599DC83D8233D60" modified="2014-06-11" version="1">MIRRAVLRCAVVATLAGASLGVLLPSTAQAAGCSPRTGPAQRQVENYLGLPVDGTASYADCLAVQKFQRRMDIRPTAGYAGPLTSSVVSRLSNASLGSCGYSSGLRVCVDLTHQVMWVTRSGKRIHGPVPIRTGRTGLITPTGTYKIQDKKISTISSYFKVKLPYWQRFYRDMGFHQTTTWLYDPGSPGSHGCINLLPADATALYSYTRRGTPVKIFGRKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZKB6</accession>
    <name>A0A010ZKB6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.111"/>
    <dbReference type="HOGENOM" id="CLU_087298_3_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="202" mass="21853" checksum="EDCC53A66B10A462" modified="2014-06-11" version="1">MIRIVGGHVALDLVNTVEPRVPGATDFREHLNTPAELLAWGVRVGLLEEPEAEQVRVAWGASTAAGSQALHASVEVREATYDVLLAVLGVRADASPQLDALGVRWSAATARSGLVLRPGEPVYLDVGTNPATLVQDRLVTAAVELLRTVEPRQLRACPLDQGGCGWLFLDRSKNGSRRWCAMEDCGVRAKSRRLTARRRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMD0</accession>
    <name>A0A010ZMD0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CryarDRAFT_0850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.839"/>
    <dbReference type="HOGENOM" id="CLU_044403_4_1_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EXG79804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="270" mass="28299" checksum="16FF84D4334FC537" modified="2014-06-11" version="1">MSLTATAYASPSLTAALRATPVRRVEECMGTVFSLDARGVGVDPDAVDAAIRWLHWVDRTFSTYQPDSVVSRLSRGELTVDECPAEVREVLGLVRVASIASDGYFSEAPHGFLDPTGIVKGWAVERASDMLVAAGSTSHVVNGGGDVQLVGEAGAGRPWRVGVAHPLRPRRLVAVVSASDVAVATSGTAERGRHIVDPHRGAPADELASFTVVGPRLAWVDACATAAFAMGPERGLAWIEGLPGLEALAVLPNGRTRHTTGFTAWGALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZMX0</accession>
    <name>A0A010ZMX0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_1093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848796.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1764970_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="147" mass="15309" checksum="4305AE304BEF9C92" modified="2014-06-11" version="1">MLPQTNITALPVSSPGTTGQTPNTFAQTLRELRLAAGLGLRPLARAAHVDFSTISKLEHGRRPSPDVAQALDDALQAGGRLVATAPPAKVRPENRPPAAVRVRTLRPGWVVLSADGVDFPLQTAAALTLMSQLAAEVARAGAPEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZNL9</accession>
    <name>A0A010ZNL9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (Queuine synthetase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CryarDRAFT_1325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1305"/>
    <dbReference type="HOGENOM" id="CLU_039110_2_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EXG80259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="343" mass="36340" checksum="7F376D15EB7D9729" modified="2014-06-11" version="1">MKPSTVFTLPADADAHEPPEARGSARDEVRLLVASPSGLTSTRFGRLPAYLEPGDLVVVNTSATLPAAVDGHRPDGTPVVIHFSAPRGAGWVVEVRVPDGSGPVLDGVSGERIAVPGGAGLTLREPADERAHGVRLWTADVALEGPVEAWLNRHGRPITYSYLHGRWPLSDYQPVFAREPGSAEMASAGRPFTDRLVTDLVTRGVAVAPVLLHTGVSSPEAGEGPQTEWFRVPAATARLVRSTRDAGGRVVAVGTTVTRALESAVDETGRVRAAEGWTDLVIGPDHPPRVVNGLVTGWHTPEASHLLLLEAVAGPGLVQAAYRAAVAERYRWHEFGDSCLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQH5</accession>
    <name>A0A010ZQH5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035848128.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692552_0_0_11"/>
    <dbReference type="OrthoDB" id="1262421at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="155" mass="16951" checksum="681D999025DC5421" modified="2014-06-11" version="1">MDDVLRIAPLVVIALGAVTVSIVTKRGLAEVGLVATLATILVITLAPAPAVFANDTNHCINGGWQPTWIPWPINGRSLNVWMFVPLGAFAALTRHRWLVLLPVAIEAAQRLLPLSRFCDSRDVADNVYGFLLGLALATLARYLGEQHGRRHRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZQM2</accession>
    <name>A0A010ZQM2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_0553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569641.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2421974_0_0_11"/>
    <dbReference type="OrthoDB" id="1696774at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG79512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="91" mass="10666" checksum="5F2E0049E6BBECFD" modified="2014-06-11" version="1">MIGQDAERLSRHYSVWQRLREARTRAREADDLTLLAYARDDLADLSLALTEFLRLHEPRDGSPWCPECSGTWARVQWPCPIWQNVERSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRA9</accession>
    <name>A0A010ZRA9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_2297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850404.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2262"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG81189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="249" mass="25331" checksum="66CD7CC3F50EA72A" modified="2014-06-11" version="1">MAELDGVRALVTGGASGIGLAIATAFRDEGARVAVLDVADAGPADVVYVRADLTDDDAVRAAVASVASRLGGLDVLVNNAGTGAQGSVEQSTDAEWHRVLDVNVVGTARVSRAAWPHLRESARAAIVNTASIASTAGLPQRAVYSASKGAVSALTRAMAADGMPDGIRVNAVNPGTADTPWVGRLLEGAPDPAAERAALEARQPHGRLVSAEEIARAVVYLASPRSGSTTGVELAVDGGMQGLRLRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZRP9</accession>
    <name>A0A010ZRP9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ORF">CryarDRAFT_2409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 44712</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2372"/>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_11"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EXG81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="207" mass="22257" checksum="D20FE91148631339" modified="2014-06-11" version="1">MIGVFALQGDVREHVAALRAAGAEAVPVRRPSELAEVDGLVIPGGESTVMSRLATVFELREPIRARIASGMPVYGSCAGMIMLASDVLDGRSDQESFGGIDMVVRRNAFGRQVDSFETDLDFEGVDGEPVHAVFIRAPWVEKVGSDVEVLARVSGGPADGRIVAVRQGNLLATSFHPELTGDLRVHDLFVRMVQEATDDRATEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVC7</accession>
    <name>A0A010ZVC7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852577.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_0_0_11"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="178"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="350" mass="35756" checksum="A370B1C3A51DC1BD" modified="2014-06-11" version="1">MRAWKLNSTDDGLRVLEVPEPRLRPGGVLVDVLAVHVPAYSSVLTGGARGSLPTPLVLGVGGLARVVAVADDVTGFAPGDVVVNASLLREAGAEFIVGWTGIGGRGERTPVVARLRERWRDGTFAERAVLPASVLVGVPGAGDDPRLAFLPWLSIAAEALTAQQPGERVAVLGATGQLGGAAVLVALARGASGVVAVGRNPAALARLAALDARVATVRLTGDRSADAAAIRAAGEPDVTVDALGAVPDPGPTLTGYDALRPGGTLVLIGGVRQNLTLPYGDLMRRRMTVRGSWMARPETVVAVWRLVGSGVLDLSALEPHVVGLDDPAAALELADSTSGLAFVVLVPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZVX3</accession>
    <name>A0A010ZVX3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_2468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972899_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG81357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="344" mass="35408" checksum="6AB9D1457568387C" modified="2014-06-11" version="1">MDRTTLVAAVALGLGLLLAGGGSVILAHARAAVRADRPQRGSITQFPAALSALLGFLLTSVSGAVLCWRLVPERGGTAVWAAIVAGVILFALVGAGFARVADRVEERRLLKVPDEVHRPISPPPRRAALTAAAPATEERARPAALPRPRPPAESTALGYATPLVPVPPRTPVPDAPPPAIAAPEPPAPDRTAPGPDHAAPHIPAQHDPAPDPAPRAPENASTPPETTAPTSDDPRVGYPTDFSTPTGTAGDPAPTVEAAEMTSGDPRWGDLDAGWMYHDESDDWFLAVGMVGGSCTLLGLPSFALIDPDGPEAPVGELTRAGAAELTVLPDDPDTPLTDENSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZW40</accession>
    <name>A0A010ZW40_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_4086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051570698.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1666483_0_0_11"/>
    <dbReference type="OrthoDB" id="1302285at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG82884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="158" mass="16685" checksum="DD4389B538D50924" modified="2014-06-11" version="1">MTPDWSNFEDAFGVAFAATDILPGVLSADATTRADALGYLYGALHHQDTVYGATAPAVDYVLTILGDPRADPMRVALLRWLTSVLDAARWKAGHPADVDACLARRPRVRDAMDAFRTDADLTVAHAALEVVAACEDVAPPPAARATPGGGSWSPTPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A010ZYP0</accession>
    <name>A0A010ZYP0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852014.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2632190_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="77" mass="8335" checksum="50E1F30AFE7C1DCE" modified="2014-06-11" version="1">MLVADSILDYKLTSATTTADGYPIYRCPTNWRLAVRPTQPTPPGHDPAETPAAPAAEIDPLDALLAALDHQDTHDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AC28</accession>
    <name>A0A011AC28_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CryarDRAFT_0632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG79591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040985_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001458641" evidence="2">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EXG79591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="267" mass="27593" checksum="2879E5BCF33F0C28" modified="2014-06-11" version="1">MARLVAGVVAVLVGVGSWVPAVPARGDDGPVTVTGDNRRSVDIRVRDEGPGAAGRTEPRRPTATDAPEAWDACHERNSAYGTACLAAAGGVPSPAGDSPPTLALEARSRLTLPLPTPTLSPRVRFDDGTIGGLTGTPTWLWTDPAHWAPNGTPLLRSASAGQVSATVSAAPVRLVWHPGDGTTVLCRTPGTPLTDPHRGAAGSPDCGHTYRRTSAAQPHAHYRVTIGVTWAVTWSGSDGSSGTLAPLVVTSTFDYPVREGRAQLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AEK6</accession>
    <name>A0A011AEK6_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_1545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051569891.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1519"/>
    <dbReference type="HOGENOM" id="CLU_089574_4_1_11"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG80471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="132" mass="14241" checksum="9B1F2E4693C7E5EA" modified="2014-06-11" version="1">MKVLRGLVTRVPAAEPEAAVARLSERFRFETDCADVASDLSHGVTGFVVVDARSPEKYAAGHVPGALNLPTRSITAESTGHLDRAAMYVTYCDGPHCNGSTKSALRLAELGFRVKEMLGGFHFWTLDGHPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AFA6</accession>
    <name>A0A011AFA6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CryarDRAFT_1793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG80706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.1763"/>
    <dbReference type="HOGENOM" id="CLU_404348_0_0_11"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EXG80706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="695" mass="74669" checksum="12B412BA8E041FDF" modified="2014-06-11" version="1">MLPEVTHPELIAGLVGVVAKAAERAALLAEMSAGLASVVVAAPVAPERLAGPAGGPLMDGLTLLIPRCYDRGDEATRLFTTVARALVGGVEPPSGSLSGDHDWFHALQVFPAALYRSVSPLYRSLSLSVARAERDALLDFAELLAGSGLLAPGSALRRIHGASDTDPGPERLRKVGNGFVLRLNDDEAHGTPPVWTLDLLEFQPDGEFGAIPGLADPLWFPLLAGFDEEVVRSFVAAARERGPIEWRPELVDRLSQAAGLGRSEALLLLYGLVKPGVPVRDAATEIGVPPAALDVVDDSWEYGSREQRAALVGTLLPADPRRIFDDGPAFDGIADWYRAQGRRAPVSDTVLIAAHQAKLSWQPRALTMLNAIRSAGSCRWLAPAPRDASGRIDYRALDIRDPDPDDVVRALASYLPWLAYHLPADDDFRQALPGALRTYRARLAEPEYEVALRYLDEEEWAALAHHLGATPVDKSTPAEDRVELGPFVTPDLADGRRVRVRPGLLSGPDDPALRAFEAVGSEPVEIGALRALLSDWLPRLLEGAAAVDPAAGAPHVPPAELIAEAASVLSLGADAATVYLQLLALPDPTDKNVARWTGWKPARLKKARAELAATPLVTEAKRARAGRTLFLPGGWLALKAPLPPVETWKLPLYSDPGQGTLVPLTPIPELFAAAWARVRSGDEPRFDELRTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AG50</accession>
    <name>A0A011AG50_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CryarDRAFT_2096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG81001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850148.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.2060"/>
    <dbReference type="HOGENOM" id="CLU_000445_129_3_11"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="360"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="496"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EXG81001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="745" mass="78652" checksum="4784D1E7A04068BE" modified="2014-06-11" version="1">MTERPGRLTRAALLGALLSAGYLPLAWNAPIGPAWIGWIAPGATVLVGLVAVARLVIATPLEDASRRFWRVLWVAVGIIGAGGVGQAVDALSGPGGPTQIMSLRTAGAFVVGLLFVLAALLLLPVGRLSRTQWLTFGLDAATVFAGATLFTWYFALRTMDDFESTNGSALPLVAIVVCGFLGVFALLKVSFAGVRQVDPGALQYLAIAALTGASTAGLAPLLASRPYLNTSFLAFPAAFLFLTVAAERQRRVALAALDAPVEAPRRRTGRALHLLPYVAVALTDGLLLVSSSSRPVIVGTVVLTALVGARQWLSSRENGRLLGQLRSSENRLSHQAGHDGLTGLANRTLFVSRLEESLGPDVAVALLDLDDFKQVNDRLGHGAGDALLVAAAARVQGAVGPSDTVARLGGDEFAVLLRGPVGDRLDRILAALAEPLLVAGDELRIRASIGLAEGWAGATSSELVRRADVAMYAAKAGRDGSWARFVPALDAPAADQARLAAGLRDGLGRGDFRVLYQPIVELPSRRITGVEALVRWHDPERGVIPPDQFIPVAERSGLIVPLGQWVLREACRDASAWPGVYVCVNVSPRQLDDPDFVADVAVALADSGLPADRLVLEVTETAVFNGGPAVDALNLLREMGVRIALDDFGTGQSSLGLLLTCPVDVLKVDKSFVDGVTEPGERAVIVQFLSQVASGLNLDTVAEGVETPEQAERLHELGYRKAQGYLFSKPVPASTLFLDRVLSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKF9</accession>
    <name>A0A011AKF9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CryarDRAFT_3643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 44712</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852257.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132523_0_0_11"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EXG82456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="174" mass="18491" checksum="DC6C0B7AFCFB2612" modified="2014-06-11" version="1">MRSLIVVESMFGNTRAVADAVADGLASAGPVTVLDLADAPPAPHVDVDLLVVGAPTHAFSLSRPNTRHAAEQQGAQHRDRGLREWLANLSPCLPGTFATAFTTRIPKKFVPGSAAKAATRRLERHGYRAAAPPEDFFVLDTAGPLRAGELERATAWGQRLAASVPDRPLKGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-06-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A011AKX1</accession>
    <name>A0A011AKX1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CryarDRAFT_3806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporangium arvum DSM 44712</name>
        <dbReference type="NCBI Taxonomy" id="927661"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Cryptosporangiales</taxon>
            <taxon>Cryptosporangiaceae</taxon>
            <taxon>Cryptosporangium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Eisen J."/>
                <person name="Huntemann M."/>
                <person name="Han J."/>
                <person name="Chen A."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Markowitz V."/>
                <person name="Palaniappan K."/>
                <person name="Ivanova N."/>
                <person name="Schaumberg A."/>
                <person name="Pati A."/>
                <person name="Liolios K."/>
                <person name="Nordberg H.P."/>
                <person name="Cantor M.N."/>
                <person name="Hua S.X."/>
                <person name="Woyke T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 44712</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JFBT01000001">
        <property type="protein sequence ID" value="EXG82611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035852529.1">
        <property type="nucleotide sequence ID" value="NZ_KK073874.1"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|927661.3.peg.3773"/>
    <dbReference type="HOGENOM" id="CLU_042118_0_0_11"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000021053">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="147"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EXG82611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000021053"/>
        </source>
    </evidence>
    <sequence length="377" mass="42707" checksum="804A0CEB61BF6890" modified="2014-06-11" version="1">MDLLVVGAGLFGLTVAERCATRLGLAVTVVDRRRHLGGNAFSDLDPATGIEVHRYGTHVFHTSNEAVWRYVNRFTEFTGYQHRVLSVHAGKIYSLPVNLGTMCAYFERVMTPDEARALIRSQTAADVDPTTLEGRAIASIGRPLYEAFVRHYTAKQWQTDPRNLPADVIGRLPVRYSFDNRYFADTYEGLPADGYGTWFERMVAHPAIEVRLGTDYFAHRTEFPADVPVVYTGALDRYFDYVHGALGWRTLDFEWRTEPTGDFQGAPVINYADPDVPFTRVHEFRHLHPERRHYPSGTTVIAREYSRFAGPQDEPYYPINSPADRAAVARYRELARAERRVLFGGRLGTYRYLDMHMAVASAMTLVDNAVSPLFGRG</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>